TUBB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)9.76645784
2oocyte development (GO:0048599)9.70993087
3protein kinase C signaling (GO:0070528)8.84853063
4positive regulation of humoral immune response (GO:0002922)8.28484764
5negative regulation of reproductive process (GO:2000242)7.95779362
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.70334094
7piRNA metabolic process (GO:0034587)7.59607557
8meiotic cell cycle (GO:0051321)7.42248174
9regulation of meiosis I (GO:0060631)7.03060833
10DNA methylation involved in gamete generation (GO:0043046)6.96691868
11reproduction (GO:0000003)6.88785740
12regulation of histone H3-K9 methylation (GO:0051570)6.65248329
13citrulline biosynthetic process (GO:0019240)6.62226830
14female gamete generation (GO:0007292)6.59309051
15positive regulation of histone H3-K4 methylation (GO:0051571)6.44719108
16retinal cone cell development (GO:0046549)6.23639591
17binding of sperm to zona pellucida (GO:0007339)6.00738938
18regulation of steroid hormone secretion (GO:2000831)5.81267734
19regulation of hypersensitivity (GO:0002883)5.77527271
20negative regulation of histone methylation (GO:0031061)5.74370791
21positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.27066582
22positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.27066582
23positive regulation of mitotic sister chromatid separation (GO:1901970)5.27066582
24regulation of cell maturation (GO:1903429)5.20899654
25regulation of phospholipid biosynthetic process (GO:0071071)5.01598691
26fertilization (GO:0009566)4.99385614
27gene silencing by RNA (GO:0031047)4.84816775
28single fertilization (GO:0007338)4.81315821
29regulation of calcium ion-dependent exocytosis (GO:0017158)4.79781386
30mitotic chromosome condensation (GO:0007076)4.74768317
31positive regulation of reproductive process (GO:2000243)4.67235496
32sperm-egg recognition (GO:0035036)4.56972324
33protein localization to kinetochore (GO:0034501)4.56958983
34glycine transport (GO:0015816)4.56634624
35positive regulation of gastrulation (GO:2000543)4.55964517
36positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.55910264
37positive regulation of chromosome segregation (GO:0051984)4.35867016
38protein localization to chromosome, centromeric region (GO:0071459)4.31980388
39regulation of reproductive process (GO:2000241)4.26190356
40DNA alkylation (GO:0006305)4.20749422
41DNA methylation (GO:0006306)4.20749422
42primitive streak formation (GO:0090009)4.18849807
43positive regulation of histone methylation (GO:0031062)4.10922993
44citrulline metabolic process (GO:0000052)4.01779822
45regulation of steroid hormone biosynthetic process (GO:0090030)4.00506218
46centriole replication (GO:0007099)3.96400585
47regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.95275920
48regulation of histone H3-K4 methylation (GO:0051569)3.94719467
49establishment of chromosome localization (GO:0051303)3.84439980
50regulation of meiosis (GO:0040020)3.75423176
51mitotic metaphase plate congression (GO:0007080)3.74879916
52cell-cell recognition (GO:0009988)3.69400985
53synaptonemal complex assembly (GO:0007130)3.65788705
54regulation of chromatin silencing (GO:0031935)3.57855112
55synapsis (GO:0007129)3.57465803
56regulation of histone methylation (GO:0031060)3.52914647
57phosphatidylinositol dephosphorylation (GO:0046856)3.51930018
58interkinetic nuclear migration (GO:0022027)3.50985641
59phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.44807776
60protein localization to chromosome (GO:0034502)3.42961646
61gene silencing (GO:0016458)3.41832299
62negative regulation of histone modification (GO:0031057)3.40149107
63phosphorelay signal transduction system (GO:0000160)3.31184264
64negative regulation of cAMP-mediated signaling (GO:0043951)3.30552543
65N-terminal protein amino acid acetylation (GO:0006474)3.29333216
66chromosome organization involved in meiosis (GO:0070192)3.29291061
67oogenesis (GO:0048477)3.29107167
68phospholipid dephosphorylation (GO:0046839)3.26620285
69peptidyl-arginine modification (GO:0018195)3.24995706
70stress granule assembly (GO:0034063)3.23005118
71negative regulation of hormone biosynthetic process (GO:0032353)3.20557385
72synaptonemal complex organization (GO:0070193)3.20056227
73regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.19793317
74regulation of chromatin binding (GO:0035561)3.18983995
75regulation of spindle organization (GO:0090224)3.17254613
76regulation of corticosteroid hormone secretion (GO:2000846)3.14759184
77attachment of spindle microtubules to kinetochore (GO:0008608)3.12644653
78male meiosis (GO:0007140)3.10566434
79regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.09146265
80positive regulation of hormone biosynthetic process (GO:0046886)3.08150687
81male meiosis I (GO:0007141)3.07279408
82regulation of meiotic cell cycle (GO:0051445)3.05805409
83labyrinthine layer development (GO:0060711)3.05637450
84type B pancreatic cell development (GO:0003323)3.05543901
85L-amino acid import (GO:0043092)3.05452398
86DNA methylation or demethylation (GO:0044728)3.03754150
87metaphase plate congression (GO:0051310)3.01951348
88histone H3-K9 demethylation (GO:0033169)3.01668127
89negative regulation of chromatin modification (GO:1903309)3.01261582
90negative regulation of hormone metabolic process (GO:0032351)3.01092749
91somite rostral/caudal axis specification (GO:0032525)3.00207036
92positive regulation of interleukin-4 production (GO:0032753)2.98963301
93neuron fate determination (GO:0048664)2.97900530
94DNA replication checkpoint (GO:0000076)2.94782262
95positive regulation of gene expression, epigenetic (GO:0045815)2.90119698
96DNA replication-dependent nucleosome organization (GO:0034723)2.89461937
97DNA replication-dependent nucleosome assembly (GO:0006335)2.89461937
98regulation of acrosome reaction (GO:0060046)13.4602554
99regulation of female gonad development (GO:2000194)12.7646592
100multicellular organism reproduction (GO:0032504)10.2222732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.12961781
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.40047461
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.85254388
4E2F7_22180533_ChIP-Seq_HELA_Human3.03089210
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.51054787
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.48617246
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.34982882
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.34982882
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.34982882
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34545658
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14059233
12EZH2_22144423_ChIP-Seq_EOC_Human17.5626832
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99849595
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93067091
15NOTCH1_21737748_ChIP-Seq_TLL_Human1.90437150
16TP63_19390658_ChIP-ChIP_HaCaT_Human1.79410152
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73764622
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65293030
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56506521
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.54678306
21GBX2_23144817_ChIP-Seq_PC3_Human1.51856759
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44993560
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.40757984
24AR_21909140_ChIP-Seq_LNCAP_Human1.37071531
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33681038
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31903979
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.29780899
28CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11410526
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09158501
30TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07590821
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07590821
32TCF4_23295773_ChIP-Seq_U87_Human1.06674209
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02818875
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02427808
35PRDM14_20953172_ChIP-Seq_ESCs_Human1.02044691
36SMAD4_21741376_ChIP-Seq_EPCs_Human0.99329292
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98147703
38CBP_20019798_ChIP-Seq_JUKART_Human0.97742257
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97742257
40GF1_26923725_Chip-Seq_HPCs_Mouse0.96129781
41GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96106297
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95659519
43LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95602853
44TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95321684
45* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94078213
46AR_25329375_ChIP-Seq_VCAP_Human0.92276063
47NANOG_20526341_ChIP-Seq_ESCs_Human0.90306794
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88103492
49SMAD4_21799915_ChIP-Seq_A2780_Human0.86845792
50RUNX2_22187159_ChIP-Seq_PCA_Human0.85279431
51FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83197049
52PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82630903
53KLF4_19829295_ChIP-Seq_ESCs_Human0.82600334
54FOXH1_21741376_ChIP-Seq_EPCs_Human0.80606845
55LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78888375
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78761010
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78053839
58SMAD3_21741376_ChIP-Seq_EPCs_Human0.77953903
59STAT3_23295773_ChIP-Seq_U87_Human0.77892060
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.75221110
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75069798
62IRF1_19129219_ChIP-ChIP_H3396_Human0.74130080
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73384551
64SMRT_27268052_Chip-Seq_Bcells_Human0.70159279
65AHR_22903824_ChIP-Seq_MCF-7_Human0.68882026
66NR3C1_23031785_ChIP-Seq_PC12_Mouse0.67707270
67* CBP_21632823_ChIP-Seq_H3396_Human0.66325320
68ZNF217_24962896_ChIP-Seq_MCF-7_Human0.66313715
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.65415240
70SALL4_22934838_ChIP-ChIP_CD34+_Human0.65060324
71OCT4_19829295_ChIP-Seq_ESCs_Human0.64959263
72STAT6_21828071_ChIP-Seq_BEAS2B_Human0.64904077
73KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.64869627
74EWS_26573619_Chip-Seq_HEK293_Human0.64081553
75DROSHA_22980978_ChIP-Seq_HELA_Human0.63983079
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.63644217
77TAL1_26923725_Chip-Seq_HPCs_Mouse0.62637575
78TP53_16413492_ChIP-PET_HCT116_Human0.62517632
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.62134828
80SOX2_21211035_ChIP-Seq_LN229_Gbm0.61903975
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.61478592
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.61425718
83SMAD3_21741376_ChIP-Seq_ESCs_Human0.61320252
84SALL1_21062744_ChIP-ChIP_HESCs_Human0.60822519
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.60210311
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.57692898
87HTT_18923047_ChIP-ChIP_STHdh_Human0.57372024
88P300_19829295_ChIP-Seq_ESCs_Human0.56666862
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.56368781
90RXR_22108803_ChIP-Seq_LS180_Human0.56349912
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.56236325
92EZH2_27304074_Chip-Seq_ESCs_Mouse0.56065943
93REST_21632747_ChIP-Seq_MESCs_Mouse0.55246081
94CDX2_22108803_ChIP-Seq_LS180_Human0.55083092
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.55010556
96P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.54503054
97TP53_22573176_ChIP-Seq_HFKS_Human0.53637868
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.53390159
99* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.53384395
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.52378068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect9.21962633
2MP0008877_abnormal_DNA_methylation4.60481435
3MP0006292_abnormal_olfactory_placode4.46509287
4MP0008789_abnormal_olfactory_epithelium4.16962278
5MP0005394_taste/olfaction_phenotype3.67669073
6MP0005499_abnormal_olfactory_system3.67669073
7MP0005395_other_phenotype3.59651033
8MP0002139_abnormal_hepatobiliary_system3.32840182
9MP0003890_abnormal_embryonic-extraembry3.03205558
10MP0003699_abnormal_female_reproductive3.01740501
11MP0008057_abnormal_DNA_replication2.80658781
12MP0002138_abnormal_hepatobiliary_system2.69106935
13MP0003693_abnormal_embryo_hatching2.59853953
14MP0001929_abnormal_gametogenesis2.49653983
15MP0010030_abnormal_orbit_morphology2.47379173
16MP0010234_abnormal_vibrissa_follicle2.34790102
17MP0005360_urolithiasis2.26308169
18MP0002234_abnormal_pharynx_morphology2.23099972
19MP0002210_abnormal_sex_determination2.08668882
20MP0003879_abnormal_hair_cell2.03416697
21MP0003183_abnormal_peptide_metabolism1.94650346
22MP0003077_abnormal_cell_cycle1.93669655
23MP0003950_abnormal_plasma_membrane1.85481816
24MP0002161_abnormal_fertility/fecundity1.85204191
25MP0000653_abnormal_sex_gland1.85013105
26MP0001119_abnormal_female_reproductive1.82983765
27MP0008058_abnormal_DNA_repair1.82727059
28MP0000566_synostosis1.80968444
29MP0010094_abnormal_chromosome_stability1.75329495
30MP0010307_abnormal_tumor_latency1.61085543
31MP0005410_abnormal_fertilization1.60117196
32MP0001730_embryonic_growth_arrest1.58923324
33MP0003111_abnormal_nucleus_morphology1.57606117
34MP0010368_abnormal_lymphatic_system1.56549188
35MP0003121_genomic_imprinting1.47900034
36MP0009840_abnormal_foam_cell1.37918595
37MP0005389_reproductive_system_phenotype1.33745420
38MP0001293_anophthalmia1.23974855
39MP0003252_abnormal_bile_duct1.21992794
40MP0002160_abnormal_reproductive_system1.18267996
41MP0008932_abnormal_embryonic_tissue1.16707222
42MP0001145_abnormal_male_reproductive1.15881422
43MP0000631_abnormal_neuroendocrine_gland1.15876157
44MP0001984_abnormal_olfaction1.14839687
45MP0000762_abnormal_tongue_morphology1.14623385
46MP0001672_abnormal_embryogenesis/_devel1.10947202
47MP0005380_embryogenesis_phenotype1.10947202
48MP0005646_abnormal_pituitary_gland1.10130945
49MP0005647_abnormal_sex_gland1.09470362
50MP0002233_abnormal_nose_morphology1.08120469
51MP0000427_abnormal_hair_cycle1.05509432
52MP0010678_abnormal_skin_adnexa1.04427131
53MP0001919_abnormal_reproductive_system1.03341167
54MP0003698_abnormal_male_reproductive0.99151504
55MP0003119_abnormal_digestive_system0.92323011
56MP0001666_abnormal_nutrient_absorption0.88409733
57MP0001664_abnormal_digestion0.88094448
58MP0000350_abnormal_cell_proliferation0.86512336
59MP0002272_abnormal_nervous_system0.81787549
60MP0005085_abnormal_gallbladder_physiolo0.80268548
61MP0003868_abnormal_feces_composition0.78089638
62MP0004142_abnormal_muscle_tone0.70909490
63MP0001324_abnormal_eye_pigmentation0.66818366
64MP0003959_abnormal_lean_body0.66010151
65MP0002089_abnormal_postnatal_growth/wei0.64969188
66MP0001986_abnormal_taste_sensitivity0.64305946
67MP0005551_abnormal_eye_electrophysiolog0.64106454
68MP0003136_yellow_coat_color0.63166639
69MP0005409_darkened_coat_color0.62765307
70MP0002084_abnormal_developmental_patter0.60305747
71MP0000049_abnormal_middle_ear0.59319966
72MP0003941_abnormal_skin_development0.57273865
73MP0000678_abnormal_parathyroid_gland0.56764957
74MP0005076_abnormal_cell_differentiation0.56596855
75MP0000733_abnormal_muscle_development0.55257947
76MP0004957_abnormal_blastocyst_morpholog0.54912779
77MP0000383_abnormal_hair_follicle0.54804358
78MP0006276_abnormal_autonomic_nervous0.52969906
79MP0002928_abnormal_bile_duct0.52605394
80MP0002796_impaired_skin_barrier0.48717635
81MP0003935_abnormal_craniofacial_develop0.47864727
82MP0002085_abnormal_embryonic_tissue0.47401453
83MP0000015_abnormal_ear_pigmentation0.46356332
84MP0001502_abnormal_circadian_rhythm0.45399460
85MP0001963_abnormal_hearing_physiology0.44967367
86MP0003984_embryonic_growth_retardation0.44490540
87MP0005501_abnormal_skin_physiology0.43963446
88MP0000377_abnormal_hair_follicle0.42597489
89MP0005075_abnormal_melanosome_morpholog0.42109708
90MP0001697_abnormal_embryo_size0.41094570
91MP0002088_abnormal_embryonic_growth/wei0.40600439
92MP0002098_abnormal_vibrissa_morphology0.39741760
93MP0006138_congestive_heart_failure0.39424125
94MP0002127_abnormal_cardiovascular_syste0.39273689
95MP0002396_abnormal_hematopoietic_system0.39158749
96MP0003755_abnormal_palate_morphology0.37039248
97MP0000428_abnormal_craniofacial_morphol0.36192221
98MP0002090_abnormal_vision0.34771275
99MP0003861_abnormal_nervous_system0.33892220
100MP0005503_abnormal_tendon_morphology0.33871185

Predicted human phenotypes

RankGene SetZ-score
1Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.95119438
2Hypoplasia of the fovea (HP:0007750)5.91726396
3Aplasia/Hypoplasia of the fovea (HP:0008060)5.91726396
4Anterior segment dysgenesis (HP:0007700)5.80295816
5Supernumerary spleens (HP:0009799)5.40026009
6Abnormality of abdominal situs (HP:0011620)5.26253914
7Abdominal situs inversus (HP:0003363)5.26253914
8Impulsivity (HP:0100710)5.18361141
9Abnormality of the fovea (HP:0000493)4.95744110
10Lip pit (HP:0100267)4.89918162
11Facial hemangioma (HP:0000329)4.80265145
12Papillary thyroid carcinoma (HP:0002895)4.70522851
13Osteomalacia (HP:0002749)4.61763972
14Abnormal gallbladder physiology (HP:0012438)4.51356348
15Cholecystitis (HP:0001082)4.51356348
16Septo-optic dysplasia (HP:0100842)4.14227784
17Oligodactyly (hands) (HP:0001180)4.01826460
18Infertility (HP:0000789)4.00347957
19Chromsome breakage (HP:0040012)3.94502593
20Hypophosphatemic rickets (HP:0004912)3.89553526
21Aplasia/Hypoplasia of the macula (HP:0008059)3.82057990
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79968923
23Apathy (HP:0000741)3.59613499
24Azoospermia (HP:0000027)3.53797486
25Aplasia/Hypoplasia affecting the retina (HP:0008061)3.51023656
26Hypergonadotropic hypogonadism (HP:0000815)3.43418226
27Diminished motivation (HP:0000745)3.43111272
28Premature ovarian failure (HP:0008209)3.41593883
29Male infertility (HP:0003251)3.35104705
30Absent septum pellucidum (HP:0001331)3.19283338
31Gonadotropin excess (HP:0000837)3.15965127
32Abnormality of the labia minora (HP:0012880)3.11233005
33Hypokinesia (HP:0002375)3.10618745
34Secondary amenorrhea (HP:0000869)3.05168417
35Median cleft lip (HP:0000161)3.01779002
36Capillary hemangiomas (HP:0005306)2.97296802
37Oligodactyly (HP:0012165)2.96647562
38Malnutrition (HP:0004395)2.92338427
39Enlarged penis (HP:0000040)2.76888177
40Wrist flexion contracture (HP:0001239)2.71547469
41Truncal obesity (HP:0001956)2.70178698
42Abnormality of the septum pellucidum (HP:0007375)2.67889200
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.67627327
44Abnormal spermatogenesis (HP:0008669)2.66081920
45Aplasia of the musculature (HP:0100854)2.66006833
46Urethral obstruction (HP:0000796)2.60515001
47Thyroid carcinoma (HP:0002890)2.60053179
48Short tibia (HP:0005736)2.56198425
49Lower limb hyperreflexia (HP:0002395)2.55646946
50Spinal cord compression (HP:0002176)2.55433238
51Fair hair (HP:0002286)2.54977755
52Abnormality of the anterior chamber (HP:0000593)2.46161602
53Metaphyseal irregularity (HP:0003025)2.43869062
54Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.35565310
55Pulmonary fibrosis (HP:0002206)2.33015348
56Myokymia (HP:0002411)2.28947311
57Intrahepatic cholestasis (HP:0001406)2.25735510
58Anhidrosis (HP:0000970)2.24266583
59Loss of speech (HP:0002371)2.24159750
60Skin pits (HP:0100276)2.23997275
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.23349323
62Dysdiadochokinesis (HP:0002075)2.23115718
63Maternal diabetes (HP:0009800)2.20946272
64Bundle branch block (HP:0011710)2.18978677
65Striae distensae (HP:0001065)2.13270533
66Conjunctival telangiectasia (HP:0000524)2.09948441
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.07226615
68Stillbirth (HP:0003826)2.07105241
69Congenital sensorineural hearing impairment (HP:0008527)2.06347828
70Abnormal biliary tract physiology (HP:0012439)2.05131824
71Bile duct proliferation (HP:0001408)2.05131824
72Cone-rod dystrophy (HP:0000548)2.04389193
73Abnormality of the phalanges of the hallux (HP:0010057)2.03057725
74Nephroblastoma (Wilms tumor) (HP:0002667)2.02322314
75Heterotopia (HP:0002282)1.99841885
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.98773509
77Ankle contracture (HP:0006466)1.97574619
78Abnormality of chromosome stability (HP:0003220)1.97518627
79Subcapsular cataract (HP:0000523)1.96630505
80Posterior subcapsular cataract (HP:0007787)1.92338826
81Shallow orbits (HP:0000586)1.91362437
82Hip contracture (HP:0003273)1.91353282
83Embryonal renal neoplasm (HP:0011794)1.90636758
84Increased circulating renin level (HP:0000848)1.90002428
85Proximal tubulopathy (HP:0000114)1.89748440
86Dysmetric saccades (HP:0000641)1.86514141
87Hydroureter (HP:0000072)1.86245381
88Abnormality of chromosome segregation (HP:0002916)1.85963709
89Abnormal ciliary motility (HP:0012262)1.82997935
90Muscle stiffness (HP:0003552)1.82037732
91Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80789694
92Limb hypertonia (HP:0002509)1.80481574
93Abnormal lung lobation (HP:0002101)1.80394812
94Meckel diverticulum (HP:0002245)1.79890479
95Small intestinal stenosis (HP:0012848)1.79450595
96Duodenal stenosis (HP:0100867)1.79450595
97Abnormality of the preputium (HP:0100587)1.79271055
98Generalized hypopigmentation of hair (HP:0011358)1.78190924
99Bicornuate uterus (HP:0000813)1.72598715
100Supranuclear gaze palsy (HP:0000605)1.71975289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.01491062
2MAP3K135.46656794
3ARAF5.35719423
4CDK124.47911912
5NEK63.13981879
6TTK3.10468132
7TAOK32.86059164
8STK242.85795302
9BRAF2.83619948
10CDK92.80483810
11AURKA2.52971510
12MET2.52727435
13MOS2.31623665
14NTRK22.12603529
15CDC71.77516728
16KSR21.74196230
17MELK1.65530585
18RAF11.63218185
19PRKCI1.58506952
20TRIM281.44312824
21CDK71.43631440
22CAMK1D1.42109913
23TNIK1.30986463
24STK31.23456754
25PLK11.23140390
26EIF2AK31.16090768
27KSR11.15960318
28BRSK11.06453930
29WNK11.01421210
30EEF2K1.01362802
31CHEK11.00643409
32PTK20.96967408
33MST40.96234381
34MAP3K80.95398447
35CAMK1G0.91103497
36TGFBR10.89743488
37BRD40.89632779
38PIM10.84502696
39NEK90.80911630
40CSNK1G10.80911353
41CDK20.79958544
42MAPKAPK30.79391421
43NEK20.79100749
44CDK80.78734201
45MTOR0.76277951
46BUB10.74032053
47NUAK10.73672445
48MARK30.70363666
49ZAK0.69887868
50TIE10.68600384
51CHEK20.66662718
52ATM0.66256392
53CSNK1D0.66221607
54TNK20.65744098
55AURKB0.63125601
56DMPK0.57463882
57STK390.57081908
58CDK10.56534207
59CSNK1G30.55172113
60PRKCZ0.53953885
61BMPR1B0.50951473
62PLK30.50379546
63PAK10.49076538
64PRKG10.46949180
65MAPK130.46205912
66NTRK30.44434231
67ATR0.40098293
68CSNK1A1L0.39359432
69CDK50.39108657
70CSNK1E0.37209046
71CHUK0.36141883
72GSK3B0.33131821
73CSNK1G20.31384033
74MAPK10.31373983
75PKN10.30763859
76MAPK100.30412866
77CDK190.30389037
78CAMK2A0.30337130
79CAMK40.27956998
80MAPK110.27942074
81TRPM70.26831253
82PDK10.26739240
83LRRK20.26248152
84PRKACA0.25771539
85TYRO30.25677037
86BRSK20.25164134
87PRKACB0.24836701
88MAP3K50.24607087
89PRKD30.24201932
90PRKAA20.21831482
91CDC42BPA0.21694602
92CLK10.20781298
93MAP3K70.20130953
94VRK10.18450720
95AKT20.18308393
96PRKAA10.18297308
97CAMK10.18204296
98MARK20.17671920
99ZAP700.15714478
100NME10.14745245

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.99724610
2Basal transcription factors_Homo sapiens_hsa030224.82133385
3Cell cycle_Homo sapiens_hsa041104.53412986
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.47771142
5Oocyte meiosis_Homo sapiens_hsa041143.37972004
6Mismatch repair_Homo sapiens_hsa034303.14932183
7Dorso-ventral axis formation_Homo sapiens_hsa043202.87219887
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.74554320
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.67032281
10Caffeine metabolism_Homo sapiens_hsa002322.67031417
11RNA degradation_Homo sapiens_hsa030182.63362193
12Base excision repair_Homo sapiens_hsa034102.33674862
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.19122368
14Fanconi anemia pathway_Homo sapiens_hsa034602.11663988
15Circadian rhythm_Homo sapiens_hsa047102.03241089
16Nucleotide excision repair_Homo sapiens_hsa034202.02388518
17Homologous recombination_Homo sapiens_hsa034402.01450893
18DNA replication_Homo sapiens_hsa030302.00797405
19RNA transport_Homo sapiens_hsa030131.86793743
20p53 signaling pathway_Homo sapiens_hsa041151.78402678
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.69689727
22Thyroid cancer_Homo sapiens_hsa052161.66073752
23Olfactory transduction_Homo sapiens_hsa047401.65996830
24Inositol phosphate metabolism_Homo sapiens_hsa005621.65627638
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34109553
26Folate biosynthesis_Homo sapiens_hsa007901.23871420
27Phototransduction_Homo sapiens_hsa047441.23003630
28mTOR signaling pathway_Homo sapiens_hsa041501.16121215
29ABC transporters_Homo sapiens_hsa020101.14427637
30mRNA surveillance pathway_Homo sapiens_hsa030151.11232393
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07985391
32TGF-beta signaling pathway_Homo sapiens_hsa043500.97660601
33Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92924841
34GABAergic synapse_Homo sapiens_hsa047270.91650121
35Bile secretion_Homo sapiens_hsa049760.88601476
36Nicotine addiction_Homo sapiens_hsa050330.86969637
37* Gap junction_Homo sapiens_hsa045400.86643345
38Lysine degradation_Homo sapiens_hsa003100.84562405
39Morphine addiction_Homo sapiens_hsa050320.81814266
40FoxO signaling pathway_Homo sapiens_hsa040680.80404586
41Adherens junction_Homo sapiens_hsa045200.78469190
42RNA polymerase_Homo sapiens_hsa030200.77949237
43MicroRNAs in cancer_Homo sapiens_hsa052060.74709344
44Notch signaling pathway_Homo sapiens_hsa043300.70931035
45Synaptic vesicle cycle_Homo sapiens_hsa047210.67378265
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67105415
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60349780
48Long-term depression_Homo sapiens_hsa047300.58633412
49Vitamin digestion and absorption_Homo sapiens_hsa049770.58612151
50Taste transduction_Homo sapiens_hsa047420.53646927
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51920630
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51095674
53Herpes simplex infection_Homo sapiens_hsa051680.49743555
54ErbB signaling pathway_Homo sapiens_hsa040120.48720312
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46337941
56Wnt signaling pathway_Homo sapiens_hsa043100.46119259
57Serotonergic synapse_Homo sapiens_hsa047260.42461461
58Purine metabolism_Homo sapiens_hsa002300.40974936
59Hippo signaling pathway_Homo sapiens_hsa043900.40428740
60Endometrial cancer_Homo sapiens_hsa052130.39432388
61Ras signaling pathway_Homo sapiens_hsa040140.39089584
62Small cell lung cancer_Homo sapiens_hsa052220.37100368
63Arginine biosynthesis_Homo sapiens_hsa002200.35671972
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35322180
65Renal cell carcinoma_Homo sapiens_hsa052110.35294034
66Viral carcinogenesis_Homo sapiens_hsa052030.35060650
67HTLV-I infection_Homo sapiens_hsa051660.32362267
68Fatty acid elongation_Homo sapiens_hsa000620.30193201
69cAMP signaling pathway_Homo sapiens_hsa040240.29320884
70HIF-1 signaling pathway_Homo sapiens_hsa040660.29262522
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.26976794
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.26328681
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25013686
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24984358
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.24164063
76Long-term potentiation_Homo sapiens_hsa047200.23701421
77Protein digestion and absorption_Homo sapiens_hsa049740.23078627
78Prostate cancer_Homo sapiens_hsa052150.22723944
79Oxytocin signaling pathway_Homo sapiens_hsa049210.22466750
80Cholinergic synapse_Homo sapiens_hsa047250.19812889
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.19644117
82Melanogenesis_Homo sapiens_hsa049160.18881498
83* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18735663
84Non-small cell lung cancer_Homo sapiens_hsa052230.18460397
85Amoebiasis_Homo sapiens_hsa051460.18202641
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17980357
87Insulin signaling pathway_Homo sapiens_hsa049100.17925956
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15972937
89Influenza A_Homo sapiens_hsa051640.15737421
90Huntingtons disease_Homo sapiens_hsa050160.15464380
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15435521
92Circadian entrainment_Homo sapiens_hsa047130.15117870
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15028692
94Non-homologous end-joining_Homo sapiens_hsa034500.13903630
95Regulation of autophagy_Homo sapiens_hsa041400.12048319
96Pathways in cancer_Homo sapiens_hsa052000.11258659
97Arginine and proline metabolism_Homo sapiens_hsa003300.11224001
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10533343
99MAPK signaling pathway_Homo sapiens_hsa040100.09945445
100Glutamatergic synapse_Homo sapiens_hsa047240.09938964

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