ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	9.96398862
2	protein kinase C signaling (GO:0070528)	9.28849418
3	regulation of DNA methylation (GO:0044030)	9.22668885
4	positive regulation of humoral immune response (GO:0002922)	8.89013345
5	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	8.19422620
6	negative regulation of reproductive process (GO:2000242)	8.14971520
7	citrulline biosynthetic process (GO:0019240)	7.32133478
8	piRNA metabolic process (GO:0034587)	7.23595785
9	positive regulation of histone H3-K4 methylation (GO:0051571)	7.17918313
10	meiotic cell cycle (GO:0051321)	7.11831656
11	reproduction (GO:0000003)	7.09940869
12	regulation of histone H3-K9 methylation (GO:0051570)	7.03559828
13	DNA methylation involved in gamete generation (GO:0043046)	6.65778588
14	binding of sperm to zona pellucida (GO:0007339)	6.13201217
15	regulation of hypersensitivity (GO:0002883)	6.06555857
16	retinal cone cell development (GO:0046549)	6.00813668
17	female gamete generation (GO:0007292)	5.96239440
18	regulation of steroid hormone secretion (GO:2000831)	5.86203741
19	regulation of meiosis I (GO:0060631)	5.81159993
20	negative regulation of histone methylation (GO:0031061)	5.80856061
21	glycine transport (GO:0015816)	5.42085276
22	positive regulation of reproductive process (GO:2000243)	5.14558297
23	single fertilization (GO:0007338)	5.14428131
24	regulation of phospholipid biosynthetic process (GO:0071071)	5.10422266
25	regulation of calcium ion-dependent exocytosis (GO:0017158)	5.02499380
26	fertilization (GO:0009566)	5.02390881
27	positive regulation of gastrulation (GO:2000543)	4.98515999
28	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	4.73437817
29	sperm-egg recognition (GO:0035036)	4.67513438
30	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	4.65306759
31	citrulline metabolic process (GO:0000052)	4.54001317
32	regulation of cell maturation (GO:1903429)	4.53783638
33	regulation of reproductive process (GO:2000241)	4.49694137
34	regulation of steroid hormone biosynthetic process (GO:0090030)	4.49583200
35	DNA methylation (GO:0006306)	4.47861824
36	DNA alkylation (GO:0006305)	4.47861824
37	gene silencing by RNA (GO:0031047)	4.42078354
38	regulation of histone H3-K4 methylation (GO:0051569)	4.38217738
39	positive regulation of histone methylation (GO:0031062)	4.35544457
40	mitotic chromosome condensation (GO:0007076)	4.35249008
41	primitive streak formation (GO:0090009)	4.24110597
42	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	4.23507181
43	type B pancreatic cell development (GO:0003323)	4.06125824
44	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.97336559
45	phosphorelay signal transduction system (GO:0000160)	3.80468322
46	cell-cell recognition (GO:0009988)	3.79819622
47	negative regulation of hormone biosynthetic process (GO:0032353)	3.70749767
48	regulation of meiosis (GO:0040020)	3.70415222
49	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.67800876
50	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.67800876
51	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.67800876
52	peptidyl-arginine modification (GO:0018195)	3.65674881
53	L-amino acid import (GO:0043092)	3.62604726
54	stress granule assembly (GO:0034063)	3.55620455
55	interkinetic nuclear migration (GO:0022027)	3.54818047
56	regulation of histone methylation (GO:0031060)	3.54675925
57	negative regulation of cAMP-mediated signaling (GO:0043951)	3.50132815
58	negative regulation of hormone metabolic process (GO:0032351)	3.49247125
59	positive regulation of meiosis (GO:0045836)	3.48995288
60	positive regulation of hormone biosynthetic process (GO:0046886)	3.45728240
61	phosphatidylinositol dephosphorylation (GO:0046856)	3.44194652
62	gene silencing (GO:0016458)	3.38389044
63	regulation of chromatin silencing (GO:0031935)	3.34151793
64	regulation of corticosteroid hormone secretion (GO:2000846)	3.32437438
65	positive regulation of chromosome segregation (GO:0051984)	3.31095237
66	negative regulation of histone modification (GO:0031057)	3.29746978
67	aggressive behavior (GO:0002118)	3.29066753
68	neuron fate determination (GO:0048664)	3.28358381
69	DNA methylation or demethylation (GO:0044728)	3.27127481
70	N-terminal protein amino acid acetylation (GO:0006474)	3.26531032
71	centriole replication (GO:0007099)	3.25500434
72	positive regulation of meiotic cell cycle (GO:0051446)	3.23801469
73	positive regulation of steroid hormone secretion (GO:2000833)	3.22977940
74	positive regulation of endothelial cell differentiation (GO:0045603)	3.21750240
75	regulation of chromatin binding (GO:0035561)	3.18611999
76	phospholipid dephosphorylation (GO:0046839)	3.18449323
77	positive regulation of interleukin-4 production (GO:0032753)	3.17197706
78	protein localization to kinetochore (GO:0034501)	3.17067749
79	establishment of chromosome localization (GO:0051303)	3.11751831
80	negative regulation of organelle assembly (GO:1902116)	3.11568862
81	synapsis (GO:0007129)	3.11471596
82	cellular response to pH (GO:0071467)	3.10976448
83	mitotic metaphase plate congression (GO:0007080)	3.10322462
84	histone H3-K4 trimethylation (GO:0080182)	3.08892675
85	regulation of uterine smooth muscle contraction (GO:0070472)	3.07292457
86	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.05572325
87	hyperosmotic salinity response (GO:0042538)	3.04771836
88	synaptonemal complex assembly (GO:0007130)	3.03551397
89	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	2.99936427
90	regulation of meiotic cell cycle (GO:0051445)	2.97699532
91	protein localization to chromosome, centromeric region (GO:0071459)	2.97459235
92	DNA replication-dependent nucleosome organization (GO:0034723)	2.94800658
93	DNA replication-dependent nucleosome assembly (GO:0006335)	2.94800658
94	negative regulation of chromatin modification (GO:1903309)	2.92736592
95	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.90727525
96	oogenesis (GO:0048477)	2.89302673
97	histone H3-K4 methylation (GO:0051568)	2.88567015
98	regulation of acrosome reaction (GO:0060046)	13.9285369
99	regulation of female gonad development (GO:2000194)	13.2369701
100	multicellular organism reproduction (GO:0032504)	10.5187488

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.80632285
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.45272420
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.41878266
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.56884374
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.07744765
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06483725
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.06304998
8	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.06304998
9	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.06304998
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06199052
11	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.00925881
12	EZH2_22144423_ChIP-Seq_EOC_Human	18.6163042
13	E2F7_22180533_ChIP-Seq_HELA_Human	1.99888488
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.97372686
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90749451
16	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.83548292
17	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.67753139
18	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.61919195
19	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.52073681
20	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.47651377
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.45698991
22	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.39579857
23	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.33117830
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31988739
25	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.16471243
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10040757
27	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07616252
28	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.06654809
29	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.03773792
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03589314
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03589314
32	TCF4_23295773_ChIP-Seq_U87_Human	1.02715112
33	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02223772
34	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97697430
35	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96969196
36	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96652274
37	AR_21909140_ChIP-Seq_LNCAP_Human	0.96642370
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96110223
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.95208325
40	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.94904834
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.94821314
42	AR_25329375_ChIP-Seq_VCAP_Human	0.94482470
43	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.94477392
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93583132
45	OCT4_19829295_ChIP-Seq_ESCs_Human	0.92146511
46	GF1_26923725_Chip-Seq_HPCs_Mouse	0.91933595
47	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.90729353
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.89265476
49	KLF4_19829295_ChIP-Seq_ESCs_Human	0.88982799
50	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88029747
51	CBP_20019798_ChIP-Seq_JUKART_Human	0.87685937
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.87685937
53	RUNX2_22187159_ChIP-Seq_PCA_Human	0.86909177
54	SMAD4_21799915_ChIP-Seq_A2780_Human	0.83483816
55	DROSHA_22980978_ChIP-Seq_HELA_Human	0.81978995
56	REST_21632747_ChIP-Seq_MESCs_Mouse	0.81582145
57	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.80600983
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.79293088
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.77050883
60	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.73421648
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.72715229
62	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.71875064
63	STAT3_23295773_ChIP-Seq_U87_Human	0.71558297
64	SMRT_27268052_Chip-Seq_Bcells_Human	0.69892219
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.68503265
66	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.68491148
67	CBP_21632823_ChIP-Seq_H3396_Human	0.67966710
68	IRF1_19129219_ChIP-ChIP_H3396_Human	0.67419689
69	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.65632139
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.65556733
71	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.65454394
72	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.64176043
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.63721838
74	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.62475416
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.62315448
76	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.62081106
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.62005647
78	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.61262168
79	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.60835286
80	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.60145505
81	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.59664679
82	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.59415417
83	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.59392335
84	AHR_22903824_ChIP-Seq_MCF-7_Human	0.58904236
85	AR_19668381_ChIP-Seq_PC3_Human	0.58253577
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.56212679
87	TP53_22573176_ChIP-Seq_HFKS_Human	0.55685856
88	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.54809277
89	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.53616467
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.52704547
91	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.52494870
92	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.52381978
93	RXR_22108803_ChIP-Seq_LS180_Human	0.51854298
94	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.51563599
95	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.51507135
96	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.50459258
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.50395292
98	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.50283049
99	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.49660515
100	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.49278720

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.58771854
2	MP0006292_abnormal_olfactory_placode	5.12338393
3	MP0008877_abnormal_DNA_methylation	4.51597430
4	MP0008789_abnormal_olfactory_epithelium	4.12454763
5	MP0005499_abnormal_olfactory_system	3.65972435
6	MP0005394_taste/olfaction_phenotype	3.65972435
7	MP0005395_other_phenotype	3.29011693
8	MP0008057_abnormal_DNA_replication	3.00634679
9	MP0002139_abnormal_hepatobiliary_system	2.97504027
10	MP0003699_abnormal_female_reproductive	2.96714401
11	MP0003890_abnormal_embryonic-extraembry	2.86163069
12	MP0010030_abnormal_orbit_morphology	2.57219197
13	MP0003693_abnormal_embryo_hatching	2.52150590
14	MP0002234_abnormal_pharynx_morphology	2.50681314
15	MP0001929_abnormal_gametogenesis	2.41636892
16	MP0002138_abnormal_hepatobiliary_system	2.30627365
17	MP0003879_abnormal_hair_cell	2.09397660
18	MP0000566_synostosis	1.98095870
19	MP0003121_genomic_imprinting	1.96040688
20	MP0010368_abnormal_lymphatic_system	1.88105127
21	MP0002210_abnormal_sex_determination	1.87889741
22	MP0001119_abnormal_female_reproductive	1.81829235
23	MP0002161_abnormal_fertility/fecundity	1.80607996
24	MP0003950_abnormal_plasma_membrane	1.70048622
25	MP0000653_abnormal_sex_gland	1.68719184
26	MP0003077_abnormal_cell_cycle	1.60514911
27	MP0010234_abnormal_vibrissa_follicle	1.59620068
28	MP0005360_urolithiasis	1.57659725
29	MP0001730_embryonic_growth_arrest	1.52871415
30	MP0008058_abnormal_DNA_repair	1.49973613
31	MP0005646_abnormal_pituitary_gland	1.49605204
32	MP0000631_abnormal_neuroendocrine_gland	1.48771131
33	MP0009379_abnormal_foot_pigmentation	1.48538202
34	MP0009840_abnormal_foam_cell	1.43424104
35	MP0001984_abnormal_olfaction	1.39328125
36	MP0010307_abnormal_tumor_latency	1.38001173
37	MP0005389_reproductive_system_phenotype	1.36075076
38	MP0005410_abnormal_fertilization	1.34914277
39	MP0003111_abnormal_nucleus_morphology	1.32724609
40	MP0003183_abnormal_peptide_metabolism	1.28837935
41	MP0001293_anophthalmia	1.25732333
42	MP0000427_abnormal_hair_cycle	1.21477765
43	MP0003252_abnormal_bile_duct	1.19050923
44	MP0010094_abnormal_chromosome_stability	1.18694172
45	MP0002160_abnormal_reproductive_system	1.16244797
46	MP0005409_darkened_coat_color	1.15674402
47	MP0004142_abnormal_muscle_tone	1.13985879
48	MP0003136_yellow_coat_color	1.11258228
49	MP0001664_abnormal_digestion	1.11115678
50	MP0003119_abnormal_digestive_system	1.06203382
51	MP0000762_abnormal_tongue_morphology	1.04644643
52	MP0001919_abnormal_reproductive_system	1.03858983
53	MP0002233_abnormal_nose_morphology	1.02975684
54	MP0005380_embryogenesis_phenotype	1.02882776
55	MP0001672_abnormal_embryogenesis/_devel	1.02882776
56	MP0002272_abnormal_nervous_system	0.96778384
57	MP0001145_abnormal_male_reproductive	0.95860648
58	MP0000049_abnormal_middle_ear	0.91014659
59	MP0003959_abnormal_lean_body	0.87602867
60	MP0005647_abnormal_sex_gland	0.86155862
61	MP0010678_abnormal_skin_adnexa	0.85902206
62	MP0003698_abnormal_male_reproductive	0.85774663
63	MP0005551_abnormal_eye_electrophysiolog	0.85476676
64	MP0000678_abnormal_parathyroid_gland	0.84803944
65	MP0006276_abnormal_autonomic_nervous	0.82300308
66	MP0008932_abnormal_embryonic_tissue	0.82178160
67	MP0001986_abnormal_taste_sensitivity	0.81566413
68	MP0001324_abnormal_eye_pigmentation	0.81274381
69	MP0001666_abnormal_nutrient_absorption	0.78679360
70	MP0001502_abnormal_circadian_rhythm	0.73799550
71	MP0000015_abnormal_ear_pigmentation	0.70107483
72	MP0000350_abnormal_cell_proliferation	0.69710926
73	MP0000372_irregular_coat_pigmentation	0.65860304
74	MP0000733_abnormal_muscle_development	0.64283246
75	MP0002734_abnormal_mechanical_nocicepti	0.64049703
76	MP0002928_abnormal_bile_duct	0.62679682
77	MP0005085_abnormal_gallbladder_physiolo	0.61947150
78	MP0008995_early_reproductive_senescence	0.58339994
79	MP0002735_abnormal_chemical_nociception	0.56071495
80	MP0002084_abnormal_developmental_patter	0.55944445
81	MP0003868_abnormal_feces_composition	0.53116651
82	MP0000383_abnormal_hair_follicle	0.51606097
83	MP0000470_abnormal_stomach_morphology	0.49990946
84	MP0003646_muscle_fatigue	0.49252289
85	MP0002098_abnormal_vibrissa_morphology	0.48863730
86	MP0003935_abnormal_craniofacial_develop	0.48598759
87	MP0001963_abnormal_hearing_physiology	0.48475013
88	MP0002085_abnormal_embryonic_tissue	0.47960067
89	MP0002127_abnormal_cardiovascular_syste	0.47486655
90	MP0002163_abnormal_gland_morphology	0.46585949
91	MP0005075_abnormal_melanosome_morpholog	0.46392703
92	MP0003941_abnormal_skin_development	0.45982467
93	MP0006138_congestive_heart_failure	0.44839231
94	MP0002089_abnormal_postnatal_growth/wei	0.43036837
95	MP0002751_abnormal_autonomic_nervous	0.42711321
96	MP0004957_abnormal_blastocyst_morpholog	0.42638691
97	MP0003635_abnormal_synaptic_transmissio	0.41354214
98	MP0003861_abnormal_nervous_system	0.40714784
99	MP0000428_abnormal_craniofacial_morphol	0.40687439
100	MP0001944_abnormal_pancreas_morphology	0.37737571

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	7.51385027
2	Hypoplasia of the fovea (HP:0007750)	6.39048232
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	6.39048232
4	Anterior segment dysgenesis (HP:0007700)	6.36806760
5	Impulsivity (HP:0100710)	5.94836686
6	Abnormality of abdominal situs (HP:0011620)	5.77748407
7	Abdominal situs inversus (HP:0003363)	5.77748407
8	Abnormality of the fovea (HP:0000493)	5.25599810
9	Lip pit (HP:0100267)	4.94493252
10	Supernumerary spleens (HP:0009799)	4.65145349
11	Septo-optic dysplasia (HP:0100842)	4.56611710
12	Apathy (HP:0000741)	4.40641617
13	Papillary thyroid carcinoma (HP:0002895)	4.26997658
14	Diminished motivation (HP:0000745)	4.20105502
15	Aplasia/Hypoplasia of the macula (HP:0008059)	4.11422247
16	Osteomalacia (HP:0002749)	4.00203929
17	Facial hemangioma (HP:0000329)	3.99297774
18	Infertility (HP:0000789)	3.84078388
19	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.79738602
20	Abnormal gallbladder physiology (HP:0012438)	3.65402733
21	Cholecystitis (HP:0001082)	3.65402733
22	Hypophosphatemic rickets (HP:0004912)	3.55935009
23	Hypergonadotropic hypogonadism (HP:0000815)	3.50597917
24	Hypokinesia (HP:0002375)	3.50408581
25	Absent septum pellucidum (HP:0001331)	3.47251421
26	Aplasia of the musculature (HP:0100854)	3.41854758
27	Oligodactyly (hands) (HP:0001180)	3.36217143
28	Premature ovarian failure (HP:0008209)	3.31417260
29	Male infertility (HP:0003251)	3.10198231
30	Myokymia (HP:0002411)	3.01365806
31	Abnormality of the labia minora (HP:0012880)	2.93391298
32	Secondary amenorrhea (HP:0000869)	2.90902107
33	Gonadotropin excess (HP:0000837)	2.83575288
34	Lower limb hyperreflexia (HP:0002395)	2.83280048
35	Abnormality of the septum pellucidum (HP:0007375)	2.81178741
36	Azoospermia (HP:0000027)	2.76298153
37	Striae distensae (HP:0001065)	2.75302276
38	Malnutrition (HP:0004395)	2.70447162
39	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.60722532
40	Median cleft lip (HP:0000161)	2.60324120
41	Truncal obesity (HP:0001956)	2.58940114
42	Bundle branch block (HP:0011710)	2.57661006
43	Abnormality of the anterior chamber (HP:0000593)	2.56564013
44	Capillary hemangiomas (HP:0005306)	2.55509075
45	Oligodactyly (HP:0012165)	2.55012849
46	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.54026746
47	Chromsome breakage (HP:0040012)	2.53027617
48	Dysdiadochokinesis (HP:0002075)	2.49252574
49	Skin pits (HP:0100276)	2.48775656
50	Pulmonary fibrosis (HP:0002206)	2.47933236
51	Urethral obstruction (HP:0000796)	2.43973811
52	Increased circulating renin level (HP:0000848)	2.42272382
53	Short tibia (HP:0005736)	2.36051303
54	Muscle stiffness (HP:0003552)	2.32568597
55	Spinal cord compression (HP:0002176)	2.26307559
56	Anhidrosis (HP:0000970)	2.26071129
57	Maternal diabetes (HP:0009800)	2.25497973
58	Enlarged penis (HP:0000040)	2.24143896
59	Thyroid carcinoma (HP:0002890)	2.22442310
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18807391
61	Wrist flexion contracture (HP:0001239)	2.17839770
62	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.17077846
63	Metaphyseal irregularity (HP:0003025)	2.16954145
64	Limb hypertonia (HP:0002509)	2.14461924
65	Hypercortisolism (HP:0001578)	2.13186705
66	Congenital sensorineural hearing impairment (HP:0008527)	2.09941773
67	Fair hair (HP:0002286)	2.05977098
68	Obstructive sleep apnea (HP:0002870)	2.05682910
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.05158383
70	Abnormal biliary tract physiology (HP:0012439)	2.02891338
71	Bile duct proliferation (HP:0001408)	2.02891338
72	Abnormal spermatogenesis (HP:0008669)	1.99471698
73	Decreased circulating renin level (HP:0003351)	1.99011657
74	Cone-rod dystrophy (HP:0000548)	1.97115013
75	Intrahepatic cholestasis (HP:0001406)	1.91174779
76	Hyperactive renin-angiotensin system (HP:0000841)	1.91007630
77	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.90500485
78	Posterior embryotoxon (HP:0000627)	1.89493929
79	Optic nerve hypoplasia (HP:0000609)	1.83474590
80	Hip contracture (HP:0003273)	1.81973953
81	Abnormality of the salivary glands (HP:0010286)	1.81688344
82	Subcapsular cataract (HP:0000523)	1.81428695
83	Abnormality of the line of Schwalbe (HP:0008048)	1.78212528
84	Abnormality of the phalanges of the hallux (HP:0010057)	1.76487407
85	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.76168913
86	Hydroureter (HP:0000072)	1.75048346
87	Abnormal ciliary motility (HP:0012262)	1.74456196
88	Heterotopia (HP:0002282)	1.74400879
89	Hypohidrosis (HP:0000966)	1.74337923
90	Posterior subcapsular cataract (HP:0007787)	1.73886470
91	Non-midline cleft lip (HP:0100335)	1.73726131
92	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.73670765
93	Proximal tubulopathy (HP:0000114)	1.73410069
94	Dysmetric saccades (HP:0000641)	1.70857214
95	Carpal bone hypoplasia (HP:0001498)	1.69965627
96	Supranuclear gaze palsy (HP:0000605)	1.67966752
97	Loss of speech (HP:0002371)	1.67663791
98	Abnormal lung lobation (HP:0002101)	1.63506751
99	Gaze-evoked nystagmus (HP:0000640)	1.63489177
100	Neurofibrillary tangles (HP:0002185)	1.62506684

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.74304067
2	ARAF	4.66679029
3	MAP3K13	4.59553999
4	CDK12	4.44464236
5	NEK6	3.52720932
6	STK24	2.82162162
7	TTK	2.69919166
8	AURKA	2.63821947
9	TAOK3	2.57664882
10	MET	2.50600030
11	NTRK2	2.42324913
12	MELK	2.37191578
13	BRAF	2.33372924
14	CDK9	2.30672232
15	TRIM28	2.25413069
16	CDK19	2.20233086
17	MOS	1.86259949
18	PRKCI	1.71035118
19	CDK7	1.62560971
20	WNK1	1.58949730
21	CAMK1D	1.57947086
22	TNIK	1.45186162
23	CDK8	1.36786735
24	CDC7	1.35536246
25	BRSK1	1.24739612
26	TGFBR1	1.19686246
27	EEF2K	1.15402437
28	PTK2	1.10685874
29	CAMK1G	1.09982491
30	STK3	1.06673892
31	PLK1	1.06219662
32	KSR2	1.05380351
33	CHEK1	1.02188756
34	RAF1	1.01105160
35	CSNK1G1	0.97926246
36	EIF2AK3	0.97250128
37	MTOR	0.91012412
38	NEK2	0.90265441
39	PIM1	0.89834639
40	BUB1	0.89060363
41	TNK2	0.88860407
42	MAP3K8	0.83084309
43	CDK2	0.82890180
44	BMPR1B	0.82340927
45	TIE1	0.81754293
46	CSNK1D	0.80204657
47	MAPK13	0.77787493
48	EPHA4	0.74852173
49	CSNK1G3	0.72216868
50	KSR1	0.67702086
51	MAP3K5	0.67209285
52	MAPKAPK3	0.67037479
53	PRKCZ	0.66599947
54	ATM	0.65017758
55	CAMK4	0.64137732
56	CHEK2	0.63283493
57	MARK3	0.60830135
58	PAK1	0.60165732
59	PRKD3	0.59994208
60	CSNK1A1L	0.58338326
61	AURKB	0.57159550
62	MARK2	0.54036075
63	CDK1	0.53071059
64	NTRK3	0.50935283
65	BRD4	0.50883790
66	PKN1	0.50518785
67	CSNK1E	0.49146933
68	CDK5	0.48297705
69	STK39	0.48024882
70	PRKG1	0.47594591
71	CSNK1G2	0.47109832
72	CDC42BPA	0.47109205
73	ZAK	0.45188059
74	PDK1	0.43880873
75	CAMK1	0.42867089
76	ATR	0.41811350
77	MAPK11	0.40522957
78	PLK3	0.40202050
79	NUAK1	0.39708820
80	TRPM7	0.39320083
81	GSK3B	0.38151973
82	NEK9	0.37484495
83	MAPK10	0.36386408
84	RPS6KB1	0.35740925
85	ZAP70	0.34328566
86	SRPK1	0.33958175
87	FLT3	0.33003203
88	CLK1	0.32348221
89	CAMK2A	0.31140772
90	RET	0.28510798
91	MAPK1	0.28106453
92	VRK1	0.27695599
93	AKT2	0.27474179
94	MAP3K7	0.26844996
95	PDPK1	0.25745432
96	STK4	0.25674525
97	PRKAA1	0.24917466
98	CHUK	0.24341489
99	PRKAA2	0.24232910
100	PRKACA	0.23812029

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ovarian steroidogenesis_Homo sapiens_hsa04913	5.42436290
2	Basal transcription factors_Homo sapiens_hsa03022	4.85884498
3	Cell cycle_Homo sapiens_hsa04110	3.78133819
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.34645980
5	Oocyte meiosis_Homo sapiens_hsa04114	3.04417853
6	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.84922293
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.80862123
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.69178204
9	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.49334412
10	Caffeine metabolism_Homo sapiens_hsa00232	2.41199442
11	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.34692221
12	RNA degradation_Homo sapiens_hsa03018	2.31207072
13	Gap junction_Homo sapiens_hsa04540	2.23280247
14	Mismatch repair_Homo sapiens_hsa03430	2.20186731
15	Base excision repair_Homo sapiens_hsa03410	2.20142429
16	Phototransduction_Homo sapiens_hsa04744	2.08354341
17	Olfactory transduction_Homo sapiens_hsa04740	1.82556013
18	Circadian rhythm_Homo sapiens_hsa04710	1.81613727
19	RNA transport_Homo sapiens_hsa03013	1.76205046
20	p53 signaling pathway_Homo sapiens_hsa04115	1.60764301
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.57086778
22	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.53959149
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51624953
24	DNA replication_Homo sapiens_hsa03030	1.41945762
25	Nicotine addiction_Homo sapiens_hsa05033	1.37855574
26	ABC transporters_Homo sapiens_hsa02010	1.35810586
27	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.34951219
28	Morphine addiction_Homo sapiens_hsa05032	1.30752799
29	GABAergic synapse_Homo sapiens_hsa04727	1.29735965
30	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.29685605
31	Thyroid cancer_Homo sapiens_hsa05216	1.23842219
32	mTOR signaling pathway_Homo sapiens_hsa04150	1.23704380
33	Homologous recombination_Homo sapiens_hsa03440	1.09221007
34	Taste transduction_Homo sapiens_hsa04742	1.02445038
35	Folate biosynthesis_Homo sapiens_hsa00790	1.01940303
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.01094599
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99720231
38	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.95772988
39	RNA polymerase_Homo sapiens_hsa03020	0.90177711
40	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.88909305
41	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.88021906
42	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.87919928
43	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.84993042
44	Lysine degradation_Homo sapiens_hsa00310	0.82022458
45	FoxO signaling pathway_Homo sapiens_hsa04068	0.75937599
46	Bile secretion_Homo sapiens_hsa04976	0.75745188
47	MicroRNAs in cancer_Homo sapiens_hsa05206	0.74499731
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70953473
49	Long-term depression_Homo sapiens_hsa04730	0.69860046
50	Adherens junction_Homo sapiens_hsa04520	0.67733886
51	Arginine biosynthesis_Homo sapiens_hsa00220	0.60210933
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57723724
53	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.56524868
54	Notch signaling pathway_Homo sapiens_hsa04330	0.52848290
55	Huntingtons disease_Homo sapiens_hsa05016	0.50814381
56	Serotonergic synapse_Homo sapiens_hsa04726	0.46057366
57	Ras signaling pathway_Homo sapiens_hsa04014	0.46019510
58	ErbB signaling pathway_Homo sapiens_hsa04012	0.45818290
59	Wnt signaling pathway_Homo sapiens_hsa04310	0.44477207
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.43238730
61	Hippo signaling pathway_Homo sapiens_hsa04390	0.41339068
62	Phagosome_Homo sapiens_hsa04145	0.41260758
63	Purine metabolism_Homo sapiens_hsa00230	0.41209235
64	Circadian entrainment_Homo sapiens_hsa04713	0.41178463
65	Endometrial cancer_Homo sapiens_hsa05213	0.39251026
66	Cholinergic synapse_Homo sapiens_hsa04725	0.37794040
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36090609
68	Insulin secretion_Homo sapiens_hsa04911	0.35561678
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32384617
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.32204525
71	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.30159481
72	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30147560
73	Herpes simplex infection_Homo sapiens_hsa05168	0.28623695
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.28050863
75	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.26145600
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.26143321
77	Amoebiasis_Homo sapiens_hsa05146	0.25962208
78	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.25936349
79	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.25498009
80	Melanogenesis_Homo sapiens_hsa04916	0.24016804
81	Prostate cancer_Homo sapiens_hsa05215	0.23838348
82	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23075143
83	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.22365424
84	Viral carcinogenesis_Homo sapiens_hsa05203	0.22226802
85	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.21446356
86	Regulation of autophagy_Homo sapiens_hsa04140	0.20592826
87	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.20381271
88	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.19908597
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.18989055
90	Insulin signaling pathway_Homo sapiens_hsa04910	0.18097636
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.16479464
92	Protein digestion and absorption_Homo sapiens_hsa04974	0.16121988
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.15765793
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.15257161
95	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.13725041
96	Renal cell carcinoma_Homo sapiens_hsa05211	0.12978240
97	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.12855503
98	Rap1 signaling pathway_Homo sapiens_hsa04015	0.12730346
99	MAPK signaling pathway_Homo sapiens_hsa04010	0.11767424
100	Amphetamine addiction_Homo sapiens_hsa05031	0.11724737

TUBB8P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »