ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	8.89782054
2	regulation of retinoic acid receptor signaling pathway (GO:0048385)	8.69632670
3	meiotic cell cycle (GO:0051321)	7.58676974
4	protein kinase C signaling (GO:0070528)	7.18396621
5	piRNA metabolic process (GO:0034587)	6.82558910
6	positive regulation of histone H3-K4 methylation (GO:0051571)	6.58464514
7	oocyte development (GO:0048599)	6.58129087
8	regulation of meiosis I (GO:0060631)	6.40507221
9	positive regulation of humoral immune response (GO:0002922)	6.33358932
10	negative regulation of reproductive process (GO:2000242)	6.32139215
11	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.12692390
12	retinal cone cell development (GO:0046549)	6.08636481
13	reproduction (GO:0000003)	5.91528455
14	regulation of histone H3-K9 methylation (GO:0051570)	5.77036849
15	female gamete generation (GO:0007292)	5.66925522
16	DNA methylation involved in gamete generation (GO:0043046)	5.32747196
17	regulation of steroid hormone secretion (GO:2000831)	5.26776274
18	glycine transport (GO:0015816)	5.24570175
19	positive regulation of gastrulation (GO:2000543)	5.23639151
20	translesion synthesis (GO:0019985)	4.96339754
21	binding of sperm to zona pellucida (GO:0007339)	4.92374309
22	mitotic chromosome condensation (GO:0007076)	4.78755858
23	negative regulation of histone methylation (GO:0031061)	4.38445973
24	single fertilization (GO:0007338)	4.34497473
25	regulation of calcium ion-dependent exocytosis (GO:0017158)	4.34022555
26	protein localization to kinetochore (GO:0034501)	4.09326269
27	primitive streak formation (GO:0090009)	4.08797178
28	centriole replication (GO:0007099)	4.08782275
29	attachment of spindle microtubules to kinetochore (GO:0008608)	4.08603028
30	fertilization (GO:0009566)	4.03168035
31	sperm-egg recognition (GO:0035036)	4.02309969
32	positive regulation of reproductive process (GO:2000243)	4.00729221
33	gene silencing by RNA (GO:0031047)	3.93526881
34	male meiosis I (GO:0007141)	3.90270911
35	citrulline biosynthetic process (GO:0019240)	3.88999114
36	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.87771856
37	synapsis (GO:0007129)	3.82867492
38	protein localization to chromosome, centromeric region (GO:0071459)	3.82815797
39	CENP-A containing nucleosome assembly (GO:0034080)	3.82334905
40	DNA replication checkpoint (GO:0000076)	3.82238168
41	regulation of reproductive process (GO:2000241)	3.75532536
42	positive regulation of histone methylation (GO:0031062)	3.72778969
43	postreplication repair (GO:0006301)	3.64439617
44	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.62266963
45	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.59468587
46	meiosis I (GO:0007127)	3.59172402
47	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.59022575
48	regulation of cell maturation (GO:1903429)	3.57257386
49	chromatin remodeling at centromere (GO:0031055)	3.57116765
50	regulation of histone H3-K4 methylation (GO:0051569)	3.54403909
51	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.52321952
52	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.52321952
53	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.52321952
54	phosphorelay signal transduction system (GO:0000160)	3.52061912
55	chromatin assembly (GO:0031497)	3.51561657
56	regulation of steroid hormone biosynthetic process (GO:0090030)	3.49172172
57	mitotic metaphase plate congression (GO:0007080)	3.42094399
58	DNA replication-dependent nucleosome assembly (GO:0006335)	3.38570466
59	DNA replication-dependent nucleosome organization (GO:0034723)	3.38570466
60	regulation of hypersensitivity (GO:0002883)	3.34053768
61	male meiosis (GO:0007140)	3.33545373
62	cell-cell recognition (GO:0009988)	3.30307268
63	mitotic G2/M transition checkpoint (GO:0044818)	3.29719011
64	L-amino acid import (GO:0043092)	3.27414560
65	meiotic nuclear division (GO:0007126)	3.22798585
66	positive regulation of chromosome segregation (GO:0051984)	3.20619421
67	establishment of chromosome localization (GO:0051303)	3.20572342
68	regulation of meiosis (GO:0040020)	3.20290874
69	negative regulation of hormone metabolic process (GO:0032351)	3.17551975
70	regulation of histone methylation (GO:0031060)	3.14966495
71	neuron fate determination (GO:0048664)	3.11573330
72	N-terminal protein amino acid acetylation (GO:0006474)	3.11005026
73	negative regulation of hormone biosynthetic process (GO:0032353)	3.09327414
74	meiotic cell cycle process (GO:1903046)	3.08813616
75	chromatin assembly or disassembly (GO:0006333)	3.04779436
76	synaptonemal complex assembly (GO:0007130)	3.02219180
77	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.01144279
78	chromosome organization involved in meiosis (GO:0070192)	3.00370528
79	relaxation of smooth muscle (GO:0044557)	3.00316343
80	aggressive behavior (GO:0002118)	2.99350213
81	regulation of uterine smooth muscle contraction (GO:0070472)	2.94391958
82	metaphase plate congression (GO:0051310)	2.93598711
83	regulation of spindle organization (GO:0090224)	2.92657129
84	somite rostral/caudal axis specification (GO:0032525)	2.91146885
85	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.90739852
86	synaptonemal complex organization (GO:0070193)	2.90400248
87	histone exchange (GO:0043486)	2.90181738
88	regulation of phospholipid biosynthetic process (GO:0071071)	2.89022550
89	DNA methylation (GO:0006306)	2.86388982
90	DNA alkylation (GO:0006305)	2.86388982
91	regulation of corticosteroid hormone secretion (GO:2000846)	2.85257571
92	DNA replication-independent nucleosome organization (GO:0034724)	2.82280936
93	DNA replication-independent nucleosome assembly (GO:0006336)	2.82280936
94	regulation of spindle checkpoint (GO:0090231)	2.77462722
95	positive regulation of meiosis (GO:0045836)	2.75778931
96	regulation of helicase activity (GO:0051095)	2.72655622
97	regulation of female gonad development (GO:2000194)	12.0992039
98	regulation of acrosome reaction (GO:0060046)	10.7415979
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	10.1772653
100	regulation of DNA methylation (GO:0044030)	10.1526596

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.28284694
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.83360161
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.73100647
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.24217428
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.11875532
6	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.69177712
7	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.69177712
8	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.69177712
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.68737003
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.56499979
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.34349401
12	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.24283236
13	EZH2_22144423_ChIP-Seq_EOC_Human	15.3742275
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.95281264
15	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.94970965
16	AR_21909140_ChIP-Seq_LNCAP_Human	1.83472247
17	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81464840
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.75665325
19	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.66776355
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.63369527
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.57890892
22	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.51464142
23	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.44822962
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.42591247
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.42557317
26	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.35317650
27	VDR_22108803_ChIP-Seq_LS180_Human	1.31445478
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30225366
29	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.29128971
30	NANOG_20526341_ChIP-Seq_ESCs_Human	1.28204453
31	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.27919998
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22773001
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21603734
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.20232626
35	ZNF274_21170338_ChIP-Seq_K562_Hela	1.17484591
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12758677
37	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.10925791
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.07912448
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07912448
40	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07468168
41	TCF4_23295773_ChIP-Seq_U87_Human	1.06174639
42	AR_25329375_ChIP-Seq_VCAP_Human	1.06012556
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05909744
44	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04958041
45	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.02587233
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01075260
47	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.00418994
48	TP53_22573176_ChIP-Seq_HFKS_Human	0.99256065
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.97779975
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96556855
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92951788
52	MYC_18940864_ChIP-ChIP_HL60_Human	0.92786566
53	GF1_26923725_Chip-Seq_HPCs_Mouse	0.91153229
54	TAF15_26573619_Chip-Seq_HEK293_Human	0.90042146
55	HTT_18923047_ChIP-ChIP_STHdh_Human	0.89741870
56	SMAD4_21799915_ChIP-Seq_A2780_Human	0.89393085
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.89250029
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.88830231
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.88595482
60	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.87187955
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86468757
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.85922735
63	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.85296574
64	P300_19829295_ChIP-Seq_ESCs_Human	0.84160171
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.83436689
66	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.82831663
67	KLF4_19829295_ChIP-Seq_ESCs_Human	0.81153220
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.81048195
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.81048195
70	EWS_26573619_Chip-Seq_HEK293_Human	0.80506329
71	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79795561
72	CBP_21632823_ChIP-Seq_H3396_Human	0.78750696
73	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.76152602
74	RNF2_27304074_Chip-Seq_NSC_Mouse	0.75710674
75	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.75576885
76	STAT3_23295773_ChIP-Seq_U87_Human	0.74585083
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.72797685
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.72591150
79	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.71776108
80	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.71542919
81	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.70821123
82	FOXP3_21729870_ChIP-Seq_TREG_Human	0.70641803
83	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.70223104
84	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.70126436
85	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.69754995
86	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.68850831
87	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.68651951
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.68497041
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.68497041
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.67970741
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.67694072
92	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.67689771
93	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.67485211
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.67392775
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.67248027
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.66997314
97	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.66904592
98	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.66678222
99	NCOR_22424771_ChIP-Seq_293T_Human	0.65819744
100	REST_21632747_ChIP-Seq_MESCs_Mouse	0.64303316

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	7.68400064
2	MP0006292_abnormal_olfactory_placode	4.45292190
3	MP0008877_abnormal_DNA_methylation	4.28066376
4	MP0002234_abnormal_pharynx_morphology	3.40493702
5	MP0010030_abnormal_orbit_morphology	3.29400824
6	MP0008789_abnormal_olfactory_epithelium	3.09186278
7	MP0003890_abnormal_embryonic-extraembry	2.98229779
8	MP0005499_abnormal_olfactory_system	2.95781334
9	MP0005394_taste/olfaction_phenotype	2.95781334
10	MP0005395_other_phenotype	2.93294352
11	MP0005646_abnormal_pituitary_gland	2.81148890
12	MP0009379_abnormal_foot_pigmentation	2.80377663
13	MP0005360_urolithiasis	2.67900161
14	MP0002139_abnormal_hepatobiliary_system	2.64277427
15	MP0003693_abnormal_embryo_hatching	2.54620462
16	MP0000566_synostosis	2.46261179
17	MP0002138_abnormal_hepatobiliary_system	2.34985019
18	MP0003699_abnormal_female_reproductive	2.31396739
19	MP0003879_abnormal_hair_cell	2.29699302
20	MP0001929_abnormal_gametogenesis	2.24504537
21	MP0009840_abnormal_foam_cell	2.14665505
22	MP0002210_abnormal_sex_determination	2.06027684
23	MP0005410_abnormal_fertilization	1.99784876
24	MP0008057_abnormal_DNA_replication	1.97174483
25	MP0010094_abnormal_chromosome_stability	1.88527092
26	MP0001986_abnormal_taste_sensitivity	1.83788702
27	MP0001293_anophthalmia	1.70836013
28	MP0008058_abnormal_DNA_repair	1.70117734
29	MP0000653_abnormal_sex_gland	1.69865402
30	MP0010368_abnormal_lymphatic_system	1.65435905
31	MP0002160_abnormal_reproductive_system	1.65189093
32	MP0002161_abnormal_fertility/fecundity	1.58543876
33	MP0001119_abnormal_female_reproductive	1.51339976
34	MP0010307_abnormal_tumor_latency	1.49552130
35	MP0003077_abnormal_cell_cycle	1.47343838
36	MP0005389_reproductive_system_phenotype	1.46697996
37	MP0003111_abnormal_nucleus_morphology	1.45509958
38	MP0000631_abnormal_neuroendocrine_gland	1.38291889
39	MP0008004_abnormal_stomach_pH	1.33788746
40	MP0003121_genomic_imprinting	1.31797825
41	MP0005187_abnormal_penis_morphology	1.30015091
42	MP0006276_abnormal_autonomic_nervous	1.27403818
43	MP0001145_abnormal_male_reproductive	1.23163109
44	MP0000762_abnormal_tongue_morphology	1.16353304
45	MP0008932_abnormal_embryonic_tissue	1.15142526
46	MP0001666_abnormal_nutrient_absorption	1.13855827
47	MP0003698_abnormal_male_reproductive	1.12626832
48	MP0005647_abnormal_sex_gland	1.07368347
49	MP0004142_abnormal_muscle_tone	1.06911328
50	MP0001730_embryonic_growth_arrest	1.06437144
51	MP0001919_abnormal_reproductive_system	1.04688343
52	MP0003136_yellow_coat_color	1.04092270
53	MP0001346_abnormal_lacrimal_gland	1.03936194
54	MP0002233_abnormal_nose_morphology	1.03843510
55	MP0005551_abnormal_eye_electrophysiolog	0.99982251
56	MP0003315_abnormal_perineum_morphology	0.99393323
57	MP0008995_early_reproductive_senescence	0.96622030
58	MP0003183_abnormal_peptide_metabolism	0.93404064
59	MP0005380_embryogenesis_phenotype	0.89493771
60	MP0001672_abnormal_embryogenesis/_devel	0.89493771
61	MP0003119_abnormal_digestive_system	0.88740835
62	MP0002272_abnormal_nervous_system	0.88277416
63	MP0001664_abnormal_digestion	0.86859984
64	MP0000049_abnormal_middle_ear	0.86520095
65	MP0003950_abnormal_plasma_membrane	0.82664095
66	MP0003868_abnormal_feces_composition	0.80431070
67	MP0004019_abnormal_vitamin_homeostasis	0.76345998
68	MP0003252_abnormal_bile_duct	0.74421987
69	MP0001324_abnormal_eye_pigmentation	0.71466671
70	MP0005174_abnormal_tail_pigmentation	0.71055384
71	MP0000427_abnormal_hair_cycle	0.70470135
72	MP0010234_abnormal_vibrissa_follicle	0.70007980
73	MP0003959_abnormal_lean_body	0.66282058
74	MP0000350_abnormal_cell_proliferation	0.65397494
75	MP0002127_abnormal_cardiovascular_syste	0.65063433
76	MP0005085_abnormal_gallbladder_physiolo	0.63348904
77	MP0001984_abnormal_olfaction	0.62971314
78	MP0001502_abnormal_circadian_rhythm	0.60908610
79	MP0002735_abnormal_chemical_nociception	0.59613200
80	MP0003195_calcinosis	0.59593802
81	MP0004270_analgesia	0.59223638
82	MP0002090_abnormal_vision	0.59159155
83	MP0003880_abnormal_central_pattern	0.57581670
84	MP0001963_abnormal_hearing_physiology	0.57318038
85	MP0000372_irregular_coat_pigmentation	0.54982217
86	MP0002734_abnormal_mechanical_nocicepti	0.54728331
87	MP0002089_abnormal_postnatal_growth/wei	0.54537154
88	MP0003941_abnormal_skin_development	0.53465726
89	MP0003755_abnormal_palate_morphology	0.52871614
90	MP0001286_abnormal_eye_development	0.52516670
91	MP0002873_normal_phenotype	0.51180555
92	MP0002169_no_abnormal_phenotype	0.50874491
93	MP0003938_abnormal_ear_development	0.50390658
94	MP0002084_abnormal_developmental_patter	0.47699314
95	MP0000537_abnormal_urethra_morphology	0.47637968
96	MP0000613_abnormal_salivary_gland	0.46656083
97	MP0000026_abnormal_inner_ear	0.44056547
98	MP0004957_abnormal_blastocyst_morpholog	0.43288045
99	MP0003935_abnormal_craniofacial_develop	0.42274065
100	MP0003635_abnormal_synaptic_transmissio	0.40778393

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Anterior segment dysgenesis (HP:0007700)	5.37703175
2	Male infertility (HP:0003251)	5.20042324
3	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.71305845
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.61470181
5	Hypoplasia of the fovea (HP:0007750)	4.61470181
6	Impulsivity (HP:0100710)	4.48754941
7	Osteomalacia (HP:0002749)	4.48155865
8	Hypophosphatemic rickets (HP:0004912)	4.44375057
9	Abdominal situs inversus (HP:0003363)	4.43608794
10	Abnormality of abdominal situs (HP:0011620)	4.43608794
11	Supernumerary spleens (HP:0009799)	4.22356222
12	Septo-optic dysplasia (HP:0100842)	4.16602759
13	Lip pit (HP:0100267)	3.93386290
14	Infertility (HP:0000789)	3.88897082
15	Abnormality of the fovea (HP:0000493)	3.70396133
16	Premature ovarian failure (HP:0008209)	3.66872728
17	Myokymia (HP:0002411)	3.64196630
18	Abnormal gallbladder physiology (HP:0012438)	3.53203551
19	Cholecystitis (HP:0001082)	3.53203551
20	Abnormality of the labia minora (HP:0012880)	3.41057863
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.39819511
22	Absent septum pellucidum (HP:0001331)	3.36920497
23	Azoospermia (HP:0000027)	3.36843312
24	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.21408282
25	Papillary thyroid carcinoma (HP:0002895)	3.18612343
26	Chromsome breakage (HP:0040012)	3.16987262
27	Gonadotropin excess (HP:0000837)	3.05326917
28	Malnutrition (HP:0004395)	2.98007228
29	Oligodactyly (hands) (HP:0001180)	2.92605173
30	Facial hemangioma (HP:0000329)	2.87615801
31	Abnormality of the septum pellucidum (HP:0007375)	2.82602911
32	Generalized aminoaciduria (HP:0002909)	2.76734561
33	Aplasia/Hypoplasia of the macula (HP:0008059)	2.71423299
34	Median cleft lip (HP:0000161)	2.66414552
35	Cone-rod dystrophy (HP:0000548)	2.65811306
36	Stenosis of the external auditory canal (HP:0000402)	2.64693309
37	Truncal obesity (HP:0001956)	2.63966387
38	Short tibia (HP:0005736)	2.51661184
39	Spinal cord compression (HP:0002176)	2.49778253
40	Abnormal spermatogenesis (HP:0008669)	2.47003596
41	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.46803146
42	Abnormality of cochlea (HP:0000375)	2.41865498
43	Muscle stiffness (HP:0003552)	2.39646826
44	Aplasia of the musculature (HP:0100854)	2.35092143
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.32959287
46	Hypokinesia (HP:0002375)	2.32617628
47	Apathy (HP:0000741)	2.31854163
48	Nausea (HP:0002018)	2.30870674
49	Skin pits (HP:0100276)	2.20748520
50	Abnormal ciliary motility (HP:0012262)	2.20231577
51	Capillary hemangiomas (HP:0005306)	2.19961144
52	Metaphyseal irregularity (HP:0003025)	2.18285381
53	Dysdiadochokinesis (HP:0002075)	2.17328197
54	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.17203723
55	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.17017652
56	Meckel diverticulum (HP:0002245)	2.13659820
57	Abnormality of the ileum (HP:0001549)	2.13535655
58	Congenital sensorineural hearing impairment (HP:0008527)	2.12601810
59	Proximal tubulopathy (HP:0000114)	2.10144402
60	Thyroid carcinoma (HP:0002890)	2.07278490
61	Diminished motivation (HP:0000745)	2.05097090
62	Secondary amenorrhea (HP:0000869)	2.03103412
63	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.01928187
64	Maternal diabetes (HP:0009800)	2.01430553
65	Methylmalonic acidemia (HP:0002912)	2.00758184
66	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.00492666
67	Optic nerve hypoplasia (HP:0000609)	1.99024404
68	Posterior subcapsular cataract (HP:0007787)	1.98513332
69	Striae distensae (HP:0001065)	1.98299948
70	Nephroblastoma (Wilms tumor) (HP:0002667)	1.97890197
71	Pendular nystagmus (HP:0012043)	1.97308435
72	Renal cortical cysts (HP:0000803)	1.96134146
73	Lower limb hyperreflexia (HP:0002395)	1.94997290
74	Partial duplication of thumb phalanx (HP:0009944)	1.94341190
75	Oligodactyly (HP:0012165)	1.93828158
76	Hypercortisolism (HP:0001578)	1.92704801
77	Aplastic anemia (HP:0001915)	1.92490425
78	Abnormality of midbrain morphology (HP:0002418)	1.92090648
79	Molar tooth sign on MRI (HP:0002419)	1.92090648
80	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.89267755
81	Duodenal stenosis (HP:0100867)	1.87988691
82	Small intestinal stenosis (HP:0012848)	1.87988691
83	Abnormal lung lobation (HP:0002101)	1.87722792
84	Rhinitis (HP:0012384)	1.87402311
85	Embryonal renal neoplasm (HP:0011794)	1.86281020
86	Abnormality of the anterior chamber (HP:0000593)	1.86080234
87	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83963504
88	Abnormality of the preputium (HP:0100587)	1.78722402
89	Wrist flexion contracture (HP:0001239)	1.78648913
90	Megaloblastic anemia (HP:0001889)	1.77521687
91	Loss of speech (HP:0002371)	1.76851740
92	Bundle branch block (HP:0011710)	1.74850753
93	Hyperglycinemia (HP:0002154)	1.74690988
94	Colon cancer (HP:0003003)	1.74468275
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.73210363
96	Absent/shortened dynein arms (HP:0200106)	1.73210363
97	Urethral obstruction (HP:0000796)	1.72468624
98	Reticulocytopenia (HP:0001896)	1.72134581
99	Midline defect of the nose (HP:0004122)	1.71869794
100	Hypergonadotropic hypogonadism (HP:0000815)	1.71636699

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	7.38570334
2	MAP3K13	3.95297485
3	MAP3K9	3.76386502
4	ARAF	3.58160402
5	STK24	3.16219212
6	NEK6	3.02504923
7	VRK2	2.82070263
8	NTRK2	2.63308686
9	TNIK	2.62576252
10	CDC7	2.45133503
11	NUAK1	2.15752830
12	TTK	2.12685214
13	AURKA	1.96830170
14	ZAK	1.86234667
15	CDK8	1.86151835
16	CDK9	1.76637362
17	TRIM28	1.75117887
18	BRAF	1.70502794
19	TAF1	1.56625911
20	PRKD3	1.56076167
21	BUB1	1.49578693
22	CDK12	1.47864587
23	STK3	1.40507235
24	PLK1	1.39645765
25	PRKCI	1.35374434
26	MET	1.34776037
27	EIF2AK3	1.33483388
28	CDK7	1.30869969
29	VRK1	1.28444558
30	PBK	1.23894586
31	MOS	1.22220019
32	MELK	1.20962185
33	MST4	1.13773721
34	MAPK13	1.07530710
35	TLK1	1.06433157
36	BRSK1	1.05237292
37	BRSK2	0.89882455
38	BMPR1B	0.88109290
39	AURKB	0.86907186
40	NEK2	0.84389664
41	RAF1	0.82139737
42	CSNK1G1	0.79932752
43	PIM1	0.79722104
44	NME1	0.78845885
45	PLK3	0.77539208
46	CHEK1	0.77103802
47	CDK19	0.68517762
48	TGFBR1	0.64434341
49	EPHA4	0.63715276
50	MUSK	0.62250882
51	EPHB2	0.60029114
52	CSNK1G3	0.59919784
53	PKN1	0.59473529
54	CDK2	0.57126684
55	TYRO3	0.56921811
56	CSNK1D	0.56140016
57	ATM	0.56097334
58	SMG1	0.55593122
59	MARK3	0.55088243
60	IRAK2	0.53856550
61	PRKG1	0.50439642
62	GRK5	0.50142996
63	SRPK1	0.49021232
64	MAPKAPK3	0.47443748
65	PTK2	0.46460545
66	ATR	0.46013299
67	CHEK2	0.45491200
68	EIF2AK2	0.45250665
69	CSNK1G2	0.45118820
70	CSNK1E	0.44601354
71	PRKCZ	0.43999923
72	MAP3K4	0.43790662
73	PAK1	0.43771909
74	KSR1	0.43530484
75	STK38L	0.42065329
76	LATS2	0.41777995
77	PRKACB	0.41543534
78	MAP3K8	0.40181972
79	DAPK1	0.39516035
80	CDK1	0.38900550
81	DMPK	0.35744644
82	LATS1	0.35023191
83	TIE1	0.34705615
84	CSNK2A2	0.33320705
85	WNK1	0.32732326
86	STK39	0.32584035
87	STK4	0.31854252
88	CSNK1A1L	0.31566027
89	ILK	0.30654093
90	LRRK2	0.29494093
91	PRKACA	0.29027470
92	BCKDK	0.28992965
93	BRD4	0.28889276
94	DYRK2	0.28145440
95	TNK2	0.26602570
96	WNK3	0.24083584
97	CAMK2A	0.23171352
98	NEK9	0.21060420
99	MAPK11	0.20993405
100	PIK3CG	0.20694975

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.86242420
2	Mismatch repair_Homo sapiens_hsa03430	4.13734656
3	Cell cycle_Homo sapiens_hsa04110	3.79393233
4	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.45327567
5	Homologous recombination_Homo sapiens_hsa03440	3.02033849
6	Oocyte meiosis_Homo sapiens_hsa04114	2.52917040
7	DNA replication_Homo sapiens_hsa03030	2.41597113
8	RNA degradation_Homo sapiens_hsa03018	2.38256535
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.31340684
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29567696
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.27646240
12	Ribosome_Homo sapiens_hsa03010	2.24334899
13	Base excision repair_Homo sapiens_hsa03410	2.10133488
14	Caffeine metabolism_Homo sapiens_hsa00232	2.08697513
15	Olfactory transduction_Homo sapiens_hsa04740	1.99489019
16	RNA transport_Homo sapiens_hsa03013	1.97800740
17	Folate biosynthesis_Homo sapiens_hsa00790	1.90787159
18	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.81930483
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75725411
20	RNA polymerase_Homo sapiens_hsa03020	1.73869797
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.68504278
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.68451462
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.65170389
24	Gap junction_Homo sapiens_hsa04540	1.57511795
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55471328
26	p53 signaling pathway_Homo sapiens_hsa04115	1.48597169
27	Nicotine addiction_Homo sapiens_hsa05033	1.47354109
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.42752135
29	Phototransduction_Homo sapiens_hsa04744	1.42614240
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.37151602
31	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.35699352
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.26551389
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.24200201
34	Huntingtons disease_Homo sapiens_hsa05016	1.22252027
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.18337316
36	Circadian rhythm_Homo sapiens_hsa04710	1.15516311
37	ABC transporters_Homo sapiens_hsa02010	1.05674272
38	Morphine addiction_Homo sapiens_hsa05032	0.98255309
39	Pancreatic secretion_Homo sapiens_hsa04972	0.96557561
40	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.94748597
41	GABAergic synapse_Homo sapiens_hsa04727	0.93639020
42	Taste transduction_Homo sapiens_hsa04742	0.92830259
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.92590411
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92223632
45	Protein digestion and absorption_Homo sapiens_hsa04974	0.90798064
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.88744317
47	Parkinsons disease_Homo sapiens_hsa05012	0.88349213
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.85237534
49	Glutathione metabolism_Homo sapiens_hsa00480	0.83326840
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.77422777
51	Purine metabolism_Homo sapiens_hsa00230	0.76413039
52	Thyroid cancer_Homo sapiens_hsa05216	0.75835119
53	Serotonergic synapse_Homo sapiens_hsa04726	0.74270452
54	Spliceosome_Homo sapiens_hsa03040	0.72036761
55	Bile secretion_Homo sapiens_hsa04976	0.71174982
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.70084102
57	Regulation of autophagy_Homo sapiens_hsa04140	0.69715374
58	Oxidative phosphorylation_Homo sapiens_hsa00190	0.65847684
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60094795
60	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.57755888
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56090567
62	Circadian entrainment_Homo sapiens_hsa04713	0.54765256
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53832881
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50844009
65	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.50629044
66	Long-term depression_Homo sapiens_hsa04730	0.50197404
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.48530100
68	Fatty acid elongation_Homo sapiens_hsa00062	0.47722081
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46086980
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.44123446
71	Viral carcinogenesis_Homo sapiens_hsa05203	0.41943813
72	Alcoholism_Homo sapiens_hsa05034	0.40098821
73	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38463388
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37135119
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34960492
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34425379
77	Ras signaling pathway_Homo sapiens_hsa04014	0.31645568
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.29767938
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.28024815
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27073432
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26419702
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25659290
83	Non-homologous end-joining_Homo sapiens_hsa03450	0.25271314
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24105050
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.23958937
86	Salivary secretion_Homo sapiens_hsa04970	0.21529340
87	Metabolic pathways_Homo sapiens_hsa01100	0.19841868
88	Herpes simplex infection_Homo sapiens_hsa05168	0.19194930
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.16611827
90	Insulin secretion_Homo sapiens_hsa04911	0.16331740
91	Amphetamine addiction_Homo sapiens_hsa05031	0.15675703
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.15220911
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.14831599
94	Notch signaling pathway_Homo sapiens_hsa04330	0.14127866
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.13485925
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.13059503
97	Retinol metabolism_Homo sapiens_hsa00830	0.11553265
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.11364333
99	Adherens junction_Homo sapiens_hsa04520	0.11193485
100	Alzheimers disease_Homo sapiens_hsa05010	0.10158341

TUBB8P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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