ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of humoral immune response (GO:0002922)	9.40473362
2	regulation of DNA methylation (GO:0044030)	9.02819213
3	negative regulation of reproductive process (GO:2000242)	8.60432447
4	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	8.49341492
5	reproduction (GO:0000003)	7.70813473
6	citrulline biosynthetic process (GO:0019240)	7.43143616
7	piRNA metabolic process (GO:0034587)	7.21190889
8	meiotic cell cycle (GO:0051321)	6.97230996
9	DNA methylation involved in gamete generation (GO:0043046)	6.86557250
10	binding of sperm to zona pellucida (GO:0007339)	6.81448918
11	regulation of hypersensitivity (GO:0002883)	6.75687662
12	regulation of histone H3-K9 methylation (GO:0051570)	6.51382240
13	female gamete generation (GO:0007292)	6.37399328
14	regulation of meiosis I (GO:0060631)	6.30253396
15	positive regulation of histone H3-K4 methylation (GO:0051571)	6.22689101
16	regulation of phospholipid biosynthetic process (GO:0071071)	5.73598840
17	regulation of steroid hormone secretion (GO:2000831)	5.60702610
18	negative regulation of histone methylation (GO:0031061)	5.59926336
19	retinal cone cell development (GO:0046549)	5.56215362
20	fertilization (GO:0009566)	5.34694888
21	single fertilization (GO:0007338)	5.33608555
22	regulation of calcium ion-dependent exocytosis (GO:0017158)	5.33366394
23	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	5.32450510
24	sperm-egg recognition (GO:0035036)	5.15177387
25	positive regulation of reproductive process (GO:2000243)	5.03869852
26	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.78945373
27	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.78945373
28	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.78945373
29	regulation of cell maturation (GO:1903429)	4.74237162
30	mitotic chromosome condensation (GO:0007076)	4.67403820
31	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	4.66356350
32	gene silencing by RNA (GO:0031047)	4.62183875
33	citrulline metabolic process (GO:0000052)	4.57826059
34	regulation of reproductive process (GO:2000241)	4.51175863
35	DNA alkylation (GO:0006305)	4.26731396
36	DNA methylation (GO:0006306)	4.26731396
37	positive regulation of gastrulation (GO:2000543)	4.25060952
38	glycine transport (GO:0015816)	4.22045691
39	cell-cell recognition (GO:0009988)	4.16861116
40	protein localization to kinetochore (GO:0034501)	4.12266405
41	positive regulation of histone methylation (GO:0031062)	3.99468675
42	positive regulation of chromosome segregation (GO:0051984)	3.99225611
43	primitive streak formation (GO:0090009)	3.97064481
44	protein localization to chromosome, centromeric region (GO:0071459)	3.93134632
45	regulation of histone H3-K4 methylation (GO:0051569)	3.91540669
46	regulation of steroid hormone biosynthetic process (GO:0090030)	3.90046448
47	peptidyl-arginine modification (GO:0018195)	3.75242505
48	interkinetic nuclear migration (GO:0022027)	3.62548313
49	phosphatidylinositol dephosphorylation (GO:0046856)	3.61749913
50	regulation of chromatin silencing (GO:0031935)	3.53641431
51	positive regulation of interleukin-4 production (GO:0032753)	3.53138922
52	regulation of meiosis (GO:0040020)	3.51278042
53	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.47513180
54	regulation of histone methylation (GO:0031060)	3.45879190
55	N-terminal protein amino acid acetylation (GO:0006474)	3.40429713
56	establishment of chromosome localization (GO:0051303)	3.39370737
57	regulation of chromatin binding (GO:0035561)	3.38997967
58	negative regulation of histone modification (GO:0031057)	3.36956480
59	phospholipid dephosphorylation (GO:0046839)	3.36296851
60	gene silencing (GO:0016458)	3.34305941
61	synaptonemal complex assembly (GO:0007130)	3.34207364
62	centriole replication (GO:0007099)	3.33343239
63	mitotic metaphase plate congression (GO:0007080)	3.32891587
64	stress granule assembly (GO:0034063)	3.31746843
65	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.18708603
66	synapsis (GO:0007129)	3.15685612
67	histone H3-K4 trimethylation (GO:0080182)	3.14999062
68	positive regulation of hormone biosynthetic process (GO:0046886)	3.12288539
69	histone H3-K9 demethylation (GO:0033169)	3.12050959
70	type B pancreatic cell development (GO:0003323)	3.10736122
71	protein localization to chromosome (GO:0034502)	3.10669879
72	phosphorelay signal transduction system (GO:0000160)	3.09929619
73	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.09233720
74	DNA methylation or demethylation (GO:0044728)	3.08645382
75	regulation of spindle organization (GO:0090224)	3.05108985
76	negative regulation of hormone biosynthetic process (GO:0032353)	3.02064891
77	histone H3-K4 methylation (GO:0051568)	3.01051022
78	immunoglobulin mediated immune response (GO:0016064)	3.00044084
79	regulation of corticosteroid hormone secretion (GO:2000846)	2.98923058
80	negative regulation of chromatin modification (GO:1903309)	2.98846595
81	histone lysine demethylation (GO:0070076)	2.96714975
82	chromosome organization involved in meiosis (GO:0070192)	2.96461967
83	attachment of spindle microtubules to kinetochore (GO:0008608)	2.95443872
84	DNA replication checkpoint (GO:0000076)	2.94650348
85	male meiosis I (GO:0007141)	2.92655655
86	negative regulation of cAMP-mediated signaling (GO:0043951)	2.92283983
87	oogenesis (GO:0048477)	2.92228658
88	synaptonemal complex organization (GO:0070193)	2.92154707
89	positive regulation of calcium ion import (GO:0090280)	2.91004492
90	positive regulation of gene expression, epigenetic (GO:0045815)	2.90147335
91	male meiosis (GO:0007140)	2.87617247
92	regulation of cell cycle G2/M phase transition (GO:1902749)	2.85802588
93	regulation of meiotic cell cycle (GO:0051445)	2.85705722
94	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.83277466
95	negative regulation of hormone metabolic process (GO:0032351)	2.82815966
96	regulation of acrosome reaction (GO:0060046)	15.0805412
97	regulation of female gonad development (GO:2000194)	13.3056442
98	multicellular organism reproduction (GO:0032504)	11.3773474
99	oocyte development (GO:0048599)	10.5817354
100	protein kinase C signaling (GO:0070528)	10.0071860

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.58844477
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.80553511
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.50537378
4	E2F7_22180533_ChIP-Seq_HELA_Human	2.95476281
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.46496466
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.27835814
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15408748
8	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.10754868
9	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.10754868
10	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.10754868
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.08795519
12	EZH2_22144423_ChIP-Seq_EOC_Human	18.5576811
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99305461
14	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.95690875
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.90132148
16	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.82063033
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.63223825
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.53525125
19	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.46746801
20	AR_21909140_ChIP-Seq_LNCAP_Human	1.43093047
21	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.42959066
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38897196
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38683102
24	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.31707694
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.27812679
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.19672653
27	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17276151
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09212978
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09212978
30	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03141747
31	GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.00869077
32	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.00795095
33	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.99196649
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.98907050
35	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98702392
36	TCF4_23295773_ChIP-Seq_U87_Human	0.98124183
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94670782
38	GF1_26923725_Chip-Seq_HPCs_Mouse	0.94330918
39	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.94034048
40	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.92806971
41	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.91456770
42	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91001947
43	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89579629
44	KLF4_19829295_ChIP-Seq_ESCs_Human	0.88370401
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.86814562
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.86245623
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.84874631
48	AR_25329375_ChIP-Seq_VCAP_Human	0.84039311
49	CBP_20019798_ChIP-Seq_JUKART_Human	0.80968468
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.80968468
51	RUNX2_22187159_ChIP-Seq_PCA_Human	0.80915875
52	OCT4_19829295_ChIP-Seq_ESCs_Human	0.80000038
53	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.79956108
54	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.79776552
55	SMAD4_21799915_ChIP-Seq_A2780_Human	0.78392497
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.76378582
57	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.74914462
58	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.73342420
59	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.73010916
60	CBP_21632823_ChIP-Seq_H3396_Human	0.72108155
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.71840136
62	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.71310112
63	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.68902816
64	STAT3_23295773_ChIP-Seq_U87_Human	0.68213150
65	SMRT_27268052_Chip-Seq_Bcells_Human	0.66957616
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.63442346
67	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.63013902
68	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.62675654
69	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.62290446
70	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.61665851
71	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.61655178
72	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.60743760
73	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.60338514
74	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.59914208
75	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.59369629
76	AHR_22903824_ChIP-Seq_MCF-7_Human	0.58949379
77	RXR_22108803_ChIP-Seq_LS180_Human	0.58107518
78	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.57529732
79	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.56703870
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.56610765
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.56343740
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.55973384
83	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.55812642
84	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.54965070
85	DROSHA_22980978_ChIP-Seq_HELA_Human	0.53996113
86	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.53885501
87	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.53104708
88	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.52658304
89	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.52639873
90	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.52616708
91	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.51964503
92	REST_21632747_ChIP-Seq_MESCs_Mouse	0.51607509
93	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.51374062
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.51345062
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.51047346
96	AR_19668381_ChIP-Seq_PC3_Human	0.50871004
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.50813799
98	TP53_22573176_ChIP-Seq_HFKS_Human	0.50486148
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.50317817
100	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.50171799

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	9.36153290
2	MP0006292_abnormal_olfactory_placode	4.50586937
3	MP0008877_abnormal_DNA_methylation	4.44480534
4	MP0008789_abnormal_olfactory_epithelium	3.85994586
5	MP0005395_other_phenotype	3.64587690
6	MP0005394_taste/olfaction_phenotype	3.46402824
7	MP0005499_abnormal_olfactory_system	3.46402824
8	MP0003699_abnormal_female_reproductive	3.19507889
9	MP0002139_abnormal_hepatobiliary_system	3.08568298
10	MP0003890_abnormal_embryonic-extraembry	2.92836356
11	MP0008057_abnormal_DNA_replication	2.83279323
12	MP0003693_abnormal_embryo_hatching	2.67673891
13	MP0001929_abnormal_gametogenesis	2.64272814
14	MP0002138_abnormal_hepatobiliary_system	2.42937784
15	MP0010030_abnormal_orbit_morphology	2.38605623
16	MP0005360_urolithiasis	2.11099966
17	MP0002210_abnormal_sex_determination	2.10430111
18	MP0010234_abnormal_vibrissa_follicle	2.09900671
19	MP0002234_abnormal_pharynx_morphology	2.07628234
20	MP0001119_abnormal_female_reproductive	2.03817629
21	MP0003879_abnormal_hair_cell	1.95919404
22	MP0000566_synostosis	1.93729883
23	MP0002161_abnormal_fertility/fecundity	1.93333782
24	MP0003077_abnormal_cell_cycle	1.92562693
25	MP0000653_abnormal_sex_gland	1.92271865
26	MP0003950_abnormal_plasma_membrane	1.91542266
27	MP0008058_abnormal_DNA_repair	1.83157736
28	MP0010368_abnormal_lymphatic_system	1.78790657
29	MP0001730_embryonic_growth_arrest	1.75092754
30	MP0003183_abnormal_peptide_metabolism	1.72939928
31	MP0010094_abnormal_chromosome_stability	1.69137925
32	MP0010307_abnormal_tumor_latency	1.66376160
33	MP0003111_abnormal_nucleus_morphology	1.63691690
34	MP0009840_abnormal_foam_cell	1.62046457
35	MP0005410_abnormal_fertilization	1.52128532
36	MP0003121_genomic_imprinting	1.50782377
37	MP0005389_reproductive_system_phenotype	1.46451585
38	MP0001919_abnormal_reproductive_system	1.30848030
39	MP0005380_embryogenesis_phenotype	1.22791960
40	MP0001672_abnormal_embryogenesis/_devel	1.22791960
41	MP0001293_anophthalmia	1.19016903
42	MP0000631_abnormal_neuroendocrine_gland	1.17365370
43	MP0008932_abnormal_embryonic_tissue	1.13839355
44	MP0002160_abnormal_reproductive_system	1.12031671
45	MP0001145_abnormal_male_reproductive	1.11227227
46	MP0000762_abnormal_tongue_morphology	1.11001252
47	MP0003252_abnormal_bile_duct	1.09655358
48	MP0005646_abnormal_pituitary_gland	1.08470003
49	MP0010678_abnormal_skin_adnexa	1.06241352
50	MP0002233_abnormal_nose_morphology	1.05695419
51	MP0000427_abnormal_hair_cycle	1.05558842
52	MP0005647_abnormal_sex_gland	1.03798052
53	MP0001984_abnormal_olfaction	0.97521582
54	MP0003698_abnormal_male_reproductive	0.96152028
55	MP0001666_abnormal_nutrient_absorption	0.94784288
56	MP0003119_abnormal_digestive_system	0.94509687
57	MP0001664_abnormal_digestion	0.94413206
58	MP0000350_abnormal_cell_proliferation	0.90507681
59	MP0005409_darkened_coat_color	0.79257175
60	MP0002272_abnormal_nervous_system	0.78008124
61	MP0003959_abnormal_lean_body	0.77559905
62	MP0003868_abnormal_feces_composition	0.74238002
63	MP0005085_abnormal_gallbladder_physiolo	0.71761537
64	MP0002089_abnormal_postnatal_growth/wei	0.68389484
65	MP0001324_abnormal_eye_pigmentation	0.66985594
66	MP0004142_abnormal_muscle_tone	0.66934053
67	MP0001986_abnormal_taste_sensitivity	0.66581159
68	MP0005076_abnormal_cell_differentiation	0.65726115
69	MP0003136_yellow_coat_color	0.65085413
70	MP0000383_abnormal_hair_follicle	0.65046657
71	MP0002084_abnormal_developmental_patter	0.64644641
72	MP0000733_abnormal_muscle_development	0.62162420
73	MP0003941_abnormal_skin_development	0.61885044
74	MP0004957_abnormal_blastocyst_morpholog	0.61564866
75	MP0000678_abnormal_parathyroid_gland	0.59017090
76	MP0005551_abnormal_eye_electrophysiolog	0.58871487
77	MP0000049_abnormal_middle_ear	0.57947330
78	MP0002085_abnormal_embryonic_tissue	0.53729001
79	MP0003984_embryonic_growth_retardation	0.51715669
80	MP0006276_abnormal_autonomic_nervous	0.49843156
81	MP0003935_abnormal_craniofacial_develop	0.49654130
82	MP0000015_abnormal_ear_pigmentation	0.49450643
83	MP0002098_abnormal_vibrissa_morphology	0.49333058
84	MP0002088_abnormal_embryonic_growth/wei	0.47634241
85	MP0001697_abnormal_embryo_size	0.47139392
86	MP0001502_abnormal_circadian_rhythm	0.46130546
87	MP0002928_abnormal_bile_duct	0.45049225
88	MP0002796_impaired_skin_barrier	0.44036930
89	MP0001963_abnormal_hearing_physiology	0.42556586
90	MP0000377_abnormal_hair_follicle	0.42440001
91	MP0002127_abnormal_cardiovascular_syste	0.41563026
92	MP0005501_abnormal_skin_physiology	0.40605091
93	MP0005075_abnormal_melanosome_morpholog	0.38821934
94	MP0003329_amyloid_beta_deposits	0.38622840
95	MP0003861_abnormal_nervous_system	0.38345290
96	MP0006138_congestive_heart_failure	0.36814672
97	MP0003755_abnormal_palate_morphology	0.36788637
98	MP0000313_abnormal_cell_death	0.36480773
99	MP0003567_abnormal_fetal_cardiomyocyte	0.35489076
100	MP0000428_abnormal_craniofacial_morphol	0.34681285

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the fovea (HP:0008060)	6.41947940
2	Hypoplasia of the fovea (HP:0007750)	6.41947940
3	Anterior segment dysgenesis (HP:0007700)	6.39651670
4	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	6.14055104
5	Impulsivity (HP:0100710)	5.44529629
6	Abnormality of the fovea (HP:0000493)	5.32881771
7	Abnormality of abdominal situs (HP:0011620)	5.23505407
8	Abdominal situs inversus (HP:0003363)	5.23505407
9	Lip pit (HP:0100267)	4.95058707
10	Papillary thyroid carcinoma (HP:0002895)	4.86588691
11	Supernumerary spleens (HP:0009799)	4.63797623
12	Osteomalacia (HP:0002749)	4.46232423
13	Facial hemangioma (HP:0000329)	4.38065797
14	Infertility (HP:0000789)	4.15352117
15	Aplasia/Hypoplasia of the macula (HP:0008059)	4.14442361
16	Hypergonadotropic hypogonadism (HP:0000815)	4.14071832
17	Cholecystitis (HP:0001082)	4.07612806
18	Abnormal gallbladder physiology (HP:0012438)	4.07612806
19	Septo-optic dysplasia (HP:0100842)	3.99186614
20	Chromsome breakage (HP:0040012)	3.91213552
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.81294931
22	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.81202564
23	Hypophosphatemic rickets (HP:0004912)	3.78417063
24	Apathy (HP:0000741)	3.75535806
25	Premature ovarian failure (HP:0008209)	3.71233650
26	Secondary amenorrhea (HP:0000869)	3.69404557
27	Oligodactyly (hands) (HP:0001180)	3.61774801
28	Diminished motivation (HP:0000745)	3.56710350
29	Azoospermia (HP:0000027)	3.36853429
30	Male infertility (HP:0003251)	3.32936754
31	Hypokinesia (HP:0002375)	3.06927728
32	Gonadotropin excess (HP:0000837)	3.05953513
33	Absent septum pellucidum (HP:0001331)	2.93406880
34	Malnutrition (HP:0004395)	2.89158086
35	Aplasia of the musculature (HP:0100854)	2.82164540
36	Capillary hemangiomas (HP:0005306)	2.77657631
37	Abnormality of the labia minora (HP:0012880)	2.76265517
38	Pulmonary fibrosis (HP:0002206)	2.75711952
39	Truncal obesity (HP:0001956)	2.74462854
40	Oligodactyly (HP:0012165)	2.71241087
41	Abnormality of the anterior chamber (HP:0000593)	2.69967323
42	Thyroid carcinoma (HP:0002890)	2.67946560
43	Median cleft lip (HP:0000161)	2.65284709
44	Urethral obstruction (HP:0000796)	2.58560430
45	Abnormal spermatogenesis (HP:0008669)	2.52418271
46	Lower limb hyperreflexia (HP:0002395)	2.51969152
47	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.45966835
48	Abnormality of the septum pellucidum (HP:0007375)	2.44476655
49	Myokymia (HP:0002411)	2.43510254
50	Spinal cord compression (HP:0002176)	2.41115384
51	Metaphyseal irregularity (HP:0003025)	2.37834159
52	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.37416159
53	Anhidrosis (HP:0000970)	2.36310409
54	Enlarged penis (HP:0000040)	2.34723961
55	Wrist flexion contracture (HP:0001239)	2.30301218
56	Loss of speech (HP:0002371)	2.29824492
57	Fair hair (HP:0002286)	2.28712949
58	Skin pits (HP:0100276)	2.27871937
59	Bundle branch block (HP:0011710)	2.19102002
60	Dysdiadochokinesis (HP:0002075)	2.16406009
61	Short tibia (HP:0005736)	2.14887722
62	Cone-rod dystrophy (HP:0000548)	2.14327660
63	Maternal diabetes (HP:0009800)	2.12311582
64	Striae distensae (HP:0001065)	2.05551018
65	Subcapsular cataract (HP:0000523)	2.03860893
66	Intrahepatic cholestasis (HP:0001406)	2.02840303
67	Congenital sensorineural hearing impairment (HP:0008527)	1.98614905
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97943854
69	Increased circulating renin level (HP:0000848)	1.95963382
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.95950887
71	Nephroblastoma (Wilms tumor) (HP:0002667)	1.92674196
72	Supranuclear gaze palsy (HP:0000605)	1.92306150
73	Neurofibrillary tangles (HP:0002185)	1.91046183
74	Posterior embryotoxon (HP:0000627)	1.90947593
75	Conjunctival telangiectasia (HP:0000524)	1.90890291
76	Abnormality of chromosome stability (HP:0003220)	1.90121249
77	Primary amenorrhea (HP:0000786)	1.88951215
78	Dysmetric saccades (HP:0000641)	1.87602520
79	Bile duct proliferation (HP:0001408)	1.86959238
80	Abnormal biliary tract physiology (HP:0012439)	1.86959238
81	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.85551762
82	Abnormality of the salivary glands (HP:0010286)	1.83143233
83	Hydroureter (HP:0000072)	1.82556550
84	Embryonal renal neoplasm (HP:0011794)	1.81860085
85	Proximal tubulopathy (HP:0000114)	1.81729604
86	Meckel diverticulum (HP:0002245)	1.81579676
87	Heterotopia (HP:0002282)	1.80927240
88	Abnormality of the line of Schwalbe (HP:0008048)	1.80115503
89	Abnormality of the preputium (HP:0100587)	1.78896178
90	Small intestinal stenosis (HP:0012848)	1.77476622
91	Duodenal stenosis (HP:0100867)	1.77476622
92	Hip contracture (HP:0003273)	1.76315134
93	Posterior subcapsular cataract (HP:0007787)	1.74888517
94	Obstructive sleep apnea (HP:0002870)	1.74195266
95	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.74164576
96	Abnormality of chromosome segregation (HP:0002916)	1.73556192
97	Shallow orbits (HP:0000586)	1.73276805
98	Abnormality of the phalanges of the hallux (HP:0010057)	1.72873137
99	Stillbirth (HP:0003826)	1.71182398
100	Limb hypertonia (HP:0002509)	1.70698492

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.80831349
2	CDK12	5.25854451
3	MAP3K13	5.15371181
4	ARAF	5.03906975
5	TTK	3.12278592
6	NEK6	2.95675455
7	STK24	2.79886877
8	TAOK3	2.77614964
9	BRAF	2.63831754
10	AURKA	2.60371247
11	CDK9	2.58676272
12	MET	2.43257682
13	MOS	2.11223910
14	NTRK2	2.09322578
15	CAMK1D	1.87959072
16	MELK	1.78546852
17	TRIM28	1.66691136
18	CDC7	1.63558268
19	KSR2	1.59528254
20	RAF1	1.47338999
21	PRKCI	1.46149820
22	CDK7	1.44729991
23	CAMK1G	1.25887717
24	STK3	1.23907004
25	TNIK	1.23774109
26	PLK1	1.22990154
27	BRSK1	1.20424291
28	EEF2K	1.19628527
29	WNK1	1.18663679
30	BRD4	1.16586664
31	CHEK1	1.10472184
32	KSR1	1.06317815
33	PTK2	1.05830101
34	TGFBR1	0.98586820
35	EIF2AK3	0.96530685
36	MAP3K8	0.93090432
37	MTOR	0.89825780
38	NEK2	0.89264453
39	CDK8	0.88373027
40	BUB1	0.88251537
41	MST4	0.84533323
42	CDK2	0.82719342
43	MAPKAPK3	0.82715327
44	PIM1	0.82668926
45	CSNK1G1	0.81929886
46	MARK3	0.70847867
47	ATM	0.68652842
48	CSNK1D	0.67440121
49	CHEK2	0.67306029
50	AURKB	0.65903188
51	CDK1	0.58042737
52	TNK2	0.57570632
53	TIE1	0.57017278
54	PRKCZ	0.56248972
55	ZAK	0.55664535
56	CSNK1G3	0.54037159
57	NUAK1	0.52754287
58	PAK1	0.51886622
59	NEK9	0.51470127
60	CDK19	0.46841194
61	NTRK3	0.45259950
62	MAPK13	0.44904821
63	DMPK	0.44245750
64	BMPR1B	0.43928070
65	STK39	0.43836167
66	PLK3	0.42810129
67	PRKG1	0.41794437
68	CDK5	0.40201654
69	CAMK4	0.40083856
70	MAPK11	0.39721756
71	CSNK1E	0.39673633
72	CSNK1A1L	0.39149206
73	ATR	0.38473561
74	GSK3B	0.37255516
75	MAPK10	0.36801137
76	CDC42BPA	0.35232014
77	NME1	0.33930562
78	MAPK1	0.33507628
79	ERN1	0.33436415
80	PRKD3	0.32287265
81	CHUK	0.30943725
82	CSNK1G2	0.30527676
83	ZAP70	0.29819862
84	PDK1	0.28173999
85	MAP3K7	0.27432567
86	PKN1	0.26763208
87	PRKAA2	0.26448551
88	LRRK2	0.26396899
89	MAP3K5	0.25478491
90	MARK2	0.25457855
91	CAMK2A	0.25378306
92	CLK1	0.25316335
93	TRPM7	0.23982951
94	AKT2	0.23535738
95	PRKACB	0.23253402
96	CAMK1	0.23049122
97	PRKAA1	0.22909094
98	PRKACA	0.22622484
99	BRSK2	0.20956975
100	TYRO3	0.20025251

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ovarian steroidogenesis_Homo sapiens_hsa04913	5.44520776
2	Basal transcription factors_Homo sapiens_hsa03022	4.59003696
3	Cell cycle_Homo sapiens_hsa04110	4.33855957
4	Oocyte meiosis_Homo sapiens_hsa04114	3.23051187
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.11703899
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.91782238
7	Mismatch repair_Homo sapiens_hsa03430	2.87047749
8	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.76295999
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.60742088
10	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.44695851
11	RNA degradation_Homo sapiens_hsa03018	2.42769358
12	Gap junction_Homo sapiens_hsa04540	2.27018808
13	Base excision repair_Homo sapiens_hsa03410	2.22898694
14	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.14764945
15	Caffeine metabolism_Homo sapiens_hsa00232	2.11091293
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.97914872
17	DNA replication_Homo sapiens_hsa03030	1.94031369
18	RNA transport_Homo sapiens_hsa03013	1.92888398
19	Circadian rhythm_Homo sapiens_hsa04710	1.90758769
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.81902065
21	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.76927281
22	Homologous recombination_Homo sapiens_hsa03440	1.76520249
23	p53 signaling pathway_Homo sapiens_hsa04115	1.74659876
24	Thyroid cancer_Homo sapiens_hsa05216	1.66595047
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.56109624
26	Olfactory transduction_Homo sapiens_hsa04740	1.46855378
27	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.42632806
28	mTOR signaling pathway_Homo sapiens_hsa04150	1.27713905
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.26612964
30	Lysine degradation_Homo sapiens_hsa00310	1.15851987
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14245471
32	Phototransduction_Homo sapiens_hsa04744	1.09372646
33	ABC transporters_Homo sapiens_hsa02010	1.08649800
34	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.05223625
35	Folate biosynthesis_Homo sapiens_hsa00790	1.04979845
36	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.01570365
37	RNA polymerase_Homo sapiens_hsa03020	0.88044555
38	GABAergic synapse_Homo sapiens_hsa04727	0.84067137
39	Bile secretion_Homo sapiens_hsa04976	0.83110021
40	Adherens junction_Homo sapiens_hsa04520	0.82752519
41	FoxO signaling pathway_Homo sapiens_hsa04068	0.80558865
42	MicroRNAs in cancer_Homo sapiens_hsa05206	0.80360258
43	Notch signaling pathway_Homo sapiens_hsa04330	0.79064681
44	Morphine addiction_Homo sapiens_hsa05032	0.68784515
45	Nicotine addiction_Homo sapiens_hsa05033	0.65318240
46	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.64835226
47	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64027533
48	Taste transduction_Homo sapiens_hsa04742	0.57809020
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56856124
50	Wnt signaling pathway_Homo sapiens_hsa04310	0.54331309
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53232591
52	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52913125
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51540471
54	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.51442148
55	Long-term depression_Homo sapiens_hsa04730	0.50345608
56	Herpes simplex infection_Homo sapiens_hsa05168	0.49803442
57	ErbB signaling pathway_Homo sapiens_hsa04012	0.48226381
58	Arginine biosynthesis_Homo sapiens_hsa00220	0.45888465
59	Phagosome_Homo sapiens_hsa04145	0.43668939
60	Hippo signaling pathway_Homo sapiens_hsa04390	0.42307049
61	Endometrial cancer_Homo sapiens_hsa05213	0.39144173
62	Purine metabolism_Homo sapiens_hsa00230	0.37974716
63	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.36207277
64	Ras signaling pathway_Homo sapiens_hsa04014	0.36097080
65	Serotonergic synapse_Homo sapiens_hsa04726	0.35254187
66	Renal cell carcinoma_Homo sapiens_hsa05211	0.35007757
67	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.32141633
68	Small cell lung cancer_Homo sapiens_hsa05222	0.31732620
69	Viral carcinogenesis_Homo sapiens_hsa05203	0.28971615
70	Prostate cancer_Homo sapiens_hsa05215	0.28413945
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.25670803
72	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.25375504
73	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.25052296
74	HTLV-I infection_Homo sapiens_hsa05166	0.24665323
75	Fatty acid elongation_Homo sapiens_hsa00062	0.23667493
76	Huntingtons disease_Homo sapiens_hsa05016	0.23224526
77	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.23069496
78	Protein digestion and absorption_Homo sapiens_hsa04974	0.21860769
79	Long-term potentiation_Homo sapiens_hsa04720	0.21821759
80	Insulin signaling pathway_Homo sapiens_hsa04910	0.21517653
81	Melanogenesis_Homo sapiens_hsa04916	0.21374064
82	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.20282506
83	Influenza A_Homo sapiens_hsa05164	0.19998846
84	Amoebiasis_Homo sapiens_hsa05146	0.19249439
85	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.18800033
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.18163632
87	Cholinergic synapse_Homo sapiens_hsa04725	0.17685009
88	Non-small cell lung cancer_Homo sapiens_hsa05223	0.16997141
89	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.16185912
90	Regulation of autophagy_Homo sapiens_hsa04140	0.15868241
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.14977725
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.13400483
93	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.12417281
94	Circadian entrainment_Homo sapiens_hsa04713	0.12312681
95	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.11433944
96	Tight junction_Homo sapiens_hsa04530	0.10729563
97	Pathways in cancer_Homo sapiens_hsa05200	0.10079496
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.08740737
99	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.08727688
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.08114209

TUBB8P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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