ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	8.89918324
2	oocyte development (GO:0048599)	8.57257662
3	piRNA metabolic process (GO:0034587)	8.30835685
4	meiotic cell cycle (GO:0051321)	8.26288416
5	protein kinase C signaling (GO:0070528)	7.59290326
6	positive regulation of humoral immune response (GO:0002922)	6.96234797
7	retinal cone cell development (GO:0046549)	6.77353601
8	female gamete generation (GO:0007292)	6.72289495
9	negative regulation of reproductive process (GO:2000242)	6.71168713
10	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.70891296
11	DNA methylation involved in gamete generation (GO:0043046)	6.70379785
12	regulation of meiosis I (GO:0060631)	6.69075399
13	positive regulation of histone H3-K4 methylation (GO:0051571)	6.58604064
14	regulation of histone H3-K9 methylation (GO:0051570)	6.40284641
15	reproduction (GO:0000003)	5.93420991
16	mitotic chromosome condensation (GO:0007076)	5.78031043
17	regulation of steroid hormone secretion (GO:2000831)	5.65905801
18	negative regulation of histone methylation (GO:0031061)	5.52760127
19	glycine transport (GO:0015816)	5.51964129
20	gene silencing by RNA (GO:0031047)	5.13374098
21	protein localization to chromosome, centromeric region (GO:0071459)	5.00835102
22	binding of sperm to zona pellucida (GO:0007339)	4.91185179
23	regulation of cell maturation (GO:1903429)	4.90647608
24	protein localization to kinetochore (GO:0034501)	4.88207343
25	mitotic metaphase plate congression (GO:0007080)	4.71294465
26	attachment of spindle microtubules to kinetochore (GO:0008608)	4.63979398
27	citrulline biosynthetic process (GO:0019240)	4.61207690
28	positive regulation of reproductive process (GO:2000243)	4.52098011
29	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.49042065
30	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.49042065
31	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.49042065
32	fertilization (GO:0009566)	4.42406244
33	positive regulation of histone methylation (GO:0031062)	4.37554310
34	synapsis (GO:0007129)	4.26043179
35	positive regulation of gastrulation (GO:2000543)	4.25417142
36	single fertilization (GO:0007338)	4.22530579
37	regulation of spindle organization (GO:0090224)	4.20498562
38	positive regulation of chromosome segregation (GO:0051984)	4.09548488
39	centriole replication (GO:0007099)	4.08365115
40	regulation of calcium ion-dependent exocytosis (GO:0017158)	4.05733646
41	establishment of chromosome localization (GO:0051303)	4.04840702
42	regulation of histone H3-K4 methylation (GO:0051569)	4.01756646
43	sperm-egg recognition (GO:0035036)	3.91756279
44	L-amino acid import (GO:0043092)	3.88883943
45	regulation of steroid hormone biosynthetic process (GO:0090030)	3.87226615
46	regulation of hypersensitivity (GO:0002883)	3.83372428
47	regulation of reproductive process (GO:2000241)	3.80154897
48	regulation of histone methylation (GO:0031060)	3.78633368
49	DNA alkylation (GO:0006305)	3.77350938
50	DNA methylation (GO:0006306)	3.77350938
51	regulation of meiosis (GO:0040020)	3.73878893
52	metaphase plate congression (GO:0051310)	3.72222583
53	primitive streak formation (GO:0090009)	3.71639869
54	CENP-A containing nucleosome assembly (GO:0034080)	3.58654670
55	oogenesis (GO:0048477)	3.57519010
56	phosphorelay signal transduction system (GO:0000160)	3.54579054
57	chromosome organization involved in meiosis (GO:0070192)	3.53432305
58	protein localization to chromosome (GO:0034502)	3.52231991
59	regulation of phospholipid biosynthetic process (GO:0071071)	3.52045657
60	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.47667658
61	synaptonemal complex assembly (GO:0007130)	3.45880985
62	gene silencing (GO:0016458)	3.44173920
63	translesion synthesis (GO:0019985)	3.41213284
64	negative regulation of histone modification (GO:0031057)	3.39977026
65	labyrinthine layer development (GO:0060711)	3.37026091
66	stress granule assembly (GO:0034063)	3.36180977
67	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.32418905
68	negative regulation of hormone biosynthetic process (GO:0032353)	3.25599410
69	interkinetic nuclear migration (GO:0022027)	3.25575796
70	regulation of chromatin silencing (GO:0031935)	3.24889605
71	male meiosis I (GO:0007141)	3.23685536
72	chromatin remodeling at centromere (GO:0031055)	3.21938740
73	N-terminal protein amino acid acetylation (GO:0006474)	3.20215165
74	regulation of corticosteroid hormone secretion (GO:2000846)	3.19101912
75	DNA replication-dependent nucleosome organization (GO:0034723)	3.17413528
76	DNA replication-dependent nucleosome assembly (GO:0006335)	3.17413528
77	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.17267420
78	cell-cell recognition (GO:0009988)	3.14327298
79	negative regulation of hormone metabolic process (GO:0032351)	3.13681735
80	regulation of spindle checkpoint (GO:0090231)	3.12147393
81	phosphatidylinositol dephosphorylation (GO:0046856)	3.11626435
82	chromatin assembly (GO:0031497)	3.09316831
83	negative regulation of execution phase of apoptosis (GO:1900118)	3.07719450
84	regulation of meiotic cell cycle (GO:0051445)	3.07674662
85	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.05443472
86	DNA replication checkpoint (GO:0000076)	3.05316936
87	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.04592888
88	male meiosis (GO:0007140)	3.02488147
89	synaptonemal complex organization (GO:0070193)	3.01959286
90	meiotic cell cycle process (GO:1903046)	3.01764766
91	negative regulation of chromatin modification (GO:1903309)	3.01058781
92	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.98875585
93	relaxation of smooth muscle (GO:0044557)	2.98775550
94	negative regulation of cAMP-mediated signaling (GO:0043951)	2.98118305
95	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.94588121
96	DNA damage induced protein phosphorylation (GO:0006975)	2.93187468
97	meiotic nuclear division (GO:0007126)	2.92264734
98	regulation of female gonad development (GO:2000194)	11.5084031
99	regulation of DNA methylation (GO:0044030)	11.3012396
100	regulation of acrosome reaction (GO:0060046)	11.2589315

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.08649683
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.92835997
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.58020181
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.42599712
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.89807574
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.89807574
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.89807574
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.69419395
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.53105362
10	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.49225767
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.25088660
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.17665092
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.07251112
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06067386
15	EZH2_22144423_ChIP-Seq_EOC_Human	16.4488206
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.95538234
17	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.95308334
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.91854056
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.76325189
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68865103
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.64126534
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.48433480
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.43048805
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42127012
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37053190
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29486480
27	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.29406631
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28691441
29	AR_21909140_ChIP-Seq_LNCAP_Human	1.27255076
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.23106853
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23106853
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21693152
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14861119
34	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14302982
35	TCF4_23295773_ChIP-Seq_U87_Human	1.11180203
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.11111859
37	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.10100696
38	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05351713
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05310644
40	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03942011
41	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.02133615
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01397334
43	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01362489
44	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00133401
45	AR_25329375_ChIP-Seq_VCAP_Human	0.99406461
46	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97802298
47	SMAD4_21799915_ChIP-Seq_A2780_Human	0.96343688
48	EWS_26573619_Chip-Seq_HEK293_Human	0.96182157
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.93700018
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93185405
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93185405
52	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.92844314
53	GF1_26923725_Chip-Seq_HPCs_Mouse	0.92771782
54	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.89787645
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.88153778
56	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.87375089
57	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86911194
58	CBP_21632823_ChIP-Seq_H3396_Human	0.86311898
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.85719285
60	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85706872
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.84529352
62	HTT_18923047_ChIP-ChIP_STHdh_Human	0.84280942
63	STAT3_23295773_ChIP-Seq_U87_Human	0.83791983
64	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.82171132
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.81996979
66	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.80435731
67	P300_19829295_ChIP-Seq_ESCs_Human	0.79486273
68	DROSHA_22980978_ChIP-Seq_HELA_Human	0.79399470
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.78488183
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.77632550
71	SMRT_27268052_Chip-Seq_Bcells_Human	0.77567386
72	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.77171287
73	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.75075229
74	AHR_22903824_ChIP-Seq_MCF-7_Human	0.74940639
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.74516425
76	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.73410546
77	REST_21632747_ChIP-Seq_MESCs_Mouse	0.72359345
78	KLF4_19829295_ChIP-Seq_ESCs_Human	0.68214595
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.67353782
80	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.65994990
81	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.65840631
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.65758168
83	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.65404602
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.65309035
85	ZNF274_21170338_ChIP-Seq_K562_Hela	0.64527132
86	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.64020032
87	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.63883541
88	TP53_22573176_ChIP-Seq_HFKS_Human	0.63663591
89	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.63060115
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.62622363
91	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.62088690
92	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.61676394
93	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.60849551
94	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.60659374
95	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.59422914
96	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.59248017
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.59003589
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.58988892
99	AR_20517297_ChIP-Seq_VCAP_Human	0.58469121
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.58390448

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	9.26814302
2	MP0008877_abnormal_DNA_methylation	4.04592626
3	MP0006292_abnormal_olfactory_placode	3.93718061
4	MP0005395_other_phenotype	3.85047647
5	MP0008789_abnormal_olfactory_epithelium	3.73718497
6	MP0005394_taste/olfaction_phenotype	3.35486773
7	MP0005499_abnormal_olfactory_system	3.35486773
8	MP0002139_abnormal_hepatobiliary_system	3.20505679
9	MP0008057_abnormal_DNA_replication	3.11161048
10	MP0002138_abnormal_hepatobiliary_system	2.99159478
11	MP0005360_urolithiasis	2.96140282
12	MP0003890_abnormal_embryonic-extraembry	2.81283041
13	MP0003699_abnormal_female_reproductive	2.75447223
14	MP0010234_abnormal_vibrissa_follicle	2.73589385
15	MP0003879_abnormal_hair_cell	2.71896951
16	MP0003693_abnormal_embryo_hatching	2.65503486
17	MP0001929_abnormal_gametogenesis	2.40901759
18	MP0000566_synostosis	2.26462071
19	MP0010030_abnormal_orbit_morphology	2.18943941
20	MP0002210_abnormal_sex_determination	2.11631379
21	MP0003950_abnormal_plasma_membrane	2.03637220
22	MP0003183_abnormal_peptide_metabolism	2.02880788
23	MP0002234_abnormal_pharynx_morphology	1.98923832
24	MP0003077_abnormal_cell_cycle	1.94149616
25	MP0008058_abnormal_DNA_repair	1.88088940
26	MP0000653_abnormal_sex_gland	1.80762813
27	MP0002161_abnormal_fertility/fecundity	1.74560900
28	MP0010094_abnormal_chromosome_stability	1.73601560
29	MP0005410_abnormal_fertilization	1.57214855
30	MP0001119_abnormal_female_reproductive	1.57141719
31	MP0009840_abnormal_foam_cell	1.54902847
32	MP0003111_abnormal_nucleus_morphology	1.47696734
33	MP0001730_embryonic_growth_arrest	1.39227383
34	MP0000631_abnormal_neuroendocrine_gland	1.37312361
35	MP0010307_abnormal_tumor_latency	1.36992259
36	MP0010368_abnormal_lymphatic_system	1.34860187
37	MP0002160_abnormal_reproductive_system	1.29884810
38	MP0005646_abnormal_pituitary_gland	1.29237262
39	MP0003252_abnormal_bile_duct	1.28529855
40	MP0008932_abnormal_embryonic_tissue	1.28213618
41	MP0003121_genomic_imprinting	1.26135693
42	MP0001145_abnormal_male_reproductive	1.25312602
43	MP0001293_anophthalmia	1.23040594
44	MP0000762_abnormal_tongue_morphology	1.17904419
45	MP0005389_reproductive_system_phenotype	1.16442555
46	MP0002233_abnormal_nose_morphology	1.09165690
47	MP0005647_abnormal_sex_gland	1.08372223
48	MP0003698_abnormal_male_reproductive	1.07012718
49	MP0001986_abnormal_taste_sensitivity	1.06747615
50	MP0004142_abnormal_muscle_tone	1.02784276
51	MP0010678_abnormal_skin_adnexa	1.02422285
52	MP0005380_embryogenesis_phenotype	1.00362221
53	MP0001672_abnormal_embryogenesis/_devel	1.00362221
54	MP0002272_abnormal_nervous_system	0.98073812
55	MP0000427_abnormal_hair_cycle	0.90926761
56	MP0006276_abnormal_autonomic_nervous	0.90761220
57	MP0001664_abnormal_digestion	0.88808028
58	MP0005085_abnormal_gallbladder_physiolo	0.88606191
59	MP0003136_yellow_coat_color	0.82709962
60	MP0003119_abnormal_digestive_system	0.81929017
61	MP0001984_abnormal_olfaction	0.80122232
62	MP0001666_abnormal_nutrient_absorption	0.79386945
63	MP0000350_abnormal_cell_proliferation	0.77738124
64	MP0005551_abnormal_eye_electrophysiolog	0.74192174
65	MP0001963_abnormal_hearing_physiology	0.72680740
66	MP0000015_abnormal_ear_pigmentation	0.72580498
67	MP0000049_abnormal_middle_ear	0.72205171
68	MP0003868_abnormal_feces_composition	0.67555808
69	MP0003941_abnormal_skin_development	0.62967503
70	MP0000678_abnormal_parathyroid_gland	0.62571777
71	MP0002089_abnormal_postnatal_growth/wei	0.61790908
72	MP0001324_abnormal_eye_pigmentation	0.60943754
73	MP0001919_abnormal_reproductive_system	0.59778077
74	MP0004957_abnormal_blastocyst_morpholog	0.57010169
75	MP0002796_impaired_skin_barrier	0.56893159
76	MP0002084_abnormal_developmental_patter	0.56142545
77	MP0005075_abnormal_melanosome_morpholog	0.54578562
78	MP0009379_abnormal_foot_pigmentation	0.53652118
79	MP0001502_abnormal_circadian_rhythm	0.50573705
80	MP0002735_abnormal_chemical_nociception	0.50235224
81	MP0005501_abnormal_skin_physiology	0.49421934
82	MP0002127_abnormal_cardiovascular_syste	0.48075390
83	MP0003959_abnormal_lean_body	0.47579250
84	MP0005174_abnormal_tail_pigmentation	0.47424161
85	MP0002928_abnormal_bile_duct	0.46133631
86	MP0005503_abnormal_tendon_morphology	0.43426406
87	MP0000026_abnormal_inner_ear	0.41525113
88	MP0002085_abnormal_embryonic_tissue	0.41143222
89	MP0000733_abnormal_muscle_development	0.40519578
90	MP0005076_abnormal_cell_differentiation	0.40421961
91	MP0002873_normal_phenotype	0.40402222
92	MP0000383_abnormal_hair_follicle	0.40255809
93	MP0006138_congestive_heart_failure	0.40115622
94	MP0003935_abnormal_craniofacial_develop	0.39539561
95	MP0002169_no_abnormal_phenotype	0.39535325
96	MP0003567_abnormal_fetal_cardiomyocyte	0.39195107
97	MP0000569_abnormal_digit_pigmentation	0.39179424
98	MP0001697_abnormal_embryo_size	0.38184608
99	MP0005319_abnormal_enzyme/_coenzyme	0.38003856
100	MP0003984_embryonic_growth_retardation	0.37608849

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.32840908
2	Supernumerary spleens (HP:0009799)	5.20588299
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.20548072
4	Hypoplasia of the fovea (HP:0007750)	5.20548072
5	Osteomalacia (HP:0002749)	5.18788466
6	Male infertility (HP:0003251)	4.97495525
7	Lip pit (HP:0100267)	4.93834331
8	Anterior segment dysgenesis (HP:0007700)	4.81331001
9	Cholecystitis (HP:0001082)	4.78635697
10	Abnormal gallbladder physiology (HP:0012438)	4.78635697
11	Abdominal situs inversus (HP:0003363)	4.59335864
12	Abnormality of abdominal situs (HP:0011620)	4.59335864
13	Hypophosphatemic rickets (HP:0004912)	4.51188985
14	Impulsivity (HP:0100710)	4.46711370
15	Facial hemangioma (HP:0000329)	4.46609608
16	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.44599879
17	Papillary thyroid carcinoma (HP:0002895)	4.42432522
18	Chromsome breakage (HP:0040012)	4.42134464
19	Abnormality of the fovea (HP:0000493)	4.39747214
20	Infertility (HP:0000789)	4.13971201
21	Azoospermia (HP:0000027)	3.77242376
22	Oligodactyly (hands) (HP:0001180)	3.60140877
23	Premature ovarian failure (HP:0008209)	3.55272830
24	Septo-optic dysplasia (HP:0100842)	3.45915279
25	Malnutrition (HP:0004395)	3.36282027
26	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.32188344
27	Aplasia/Hypoplasia of the macula (HP:0008059)	3.30550544
28	Apathy (HP:0000741)	3.29646860
29	Gonadotropin excess (HP:0000837)	3.25555839
30	Diminished motivation (HP:0000745)	3.21203476
31	Hypokinesia (HP:0002375)	3.09945370
32	Median cleft lip (HP:0000161)	3.08382178
33	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.02929033
34	Truncal obesity (HP:0001956)	3.01599581
35	Abnormal biliary tract physiology (HP:0012439)	2.92768451
36	Bile duct proliferation (HP:0001408)	2.92768451
37	Absent septum pellucidum (HP:0001331)	2.91750435
38	Spinal cord compression (HP:0002176)	2.86209375
39	Abnormal spermatogenesis (HP:0008669)	2.83454767
40	Urethral obstruction (HP:0000796)	2.80427105
41	Loss of speech (HP:0002371)	2.78483491
42	Conjunctival telangiectasia (HP:0000524)	2.71564508
43	Capillary hemangiomas (HP:0005306)	2.68720567
44	Hypergonadotropic hypogonadism (HP:0000815)	2.68611105
45	Abnormality of the labia minora (HP:0012880)	2.67479180
46	Muscle stiffness (HP:0003552)	2.66163569
47	Oligodactyly (HP:0012165)	2.64428719
48	Metaphyseal irregularity (HP:0003025)	2.60636406
49	Aplasia of the musculature (HP:0100854)	2.59672499
50	Short tibia (HP:0005736)	2.59327752
51	Thyroid carcinoma (HP:0002890)	2.44964566
52	Skin pits (HP:0100276)	2.43375657
53	Proximal tubulopathy (HP:0000114)	2.39830199
54	Abnormality of the septum pellucidum (HP:0007375)	2.38992195
55	Myokymia (HP:0002411)	2.38863223
56	Generalized aminoaciduria (HP:0002909)	2.38539366
57	Lower limb hyperreflexia (HP:0002395)	2.33138170
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.26813941
59	Enlarged penis (HP:0000040)	2.26079354
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.23971228
61	Wrist flexion contracture (HP:0001239)	2.23122298
62	Striae distensae (HP:0001065)	2.21988475
63	Posterior subcapsular cataract (HP:0007787)	2.20761542
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.19952679
65	Anhidrosis (HP:0000970)	2.16079006
66	Intrahepatic cholestasis (HP:0001406)	2.15294237
67	Fair hair (HP:0002286)	2.14028309
68	Congenital sensorineural hearing impairment (HP:0008527)	2.13311231
69	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.11345300
70	Neurofibrillary tangles (HP:0002185)	2.11186477
71	Abnormality of the anterior chamber (HP:0000593)	2.07711020
72	Abnormality of chromosome stability (HP:0003220)	2.06826359
73	Dysdiadochokinesis (HP:0002075)	2.06041827
74	Bifid tongue (HP:0010297)	2.05487635
75	Molar tooth sign on MRI (HP:0002419)	2.04502108
76	Abnormality of midbrain morphology (HP:0002418)	2.04502108
77	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.02247085
78	Small intestinal stenosis (HP:0012848)	2.01854292
79	Duodenal stenosis (HP:0100867)	2.01854292
80	Meckel diverticulum (HP:0002245)	1.99682490
81	Abnormal lung lobation (HP:0002101)	1.98823441
82	Hypercortisolism (HP:0001578)	1.98470666
83	Abnormality of the renal collecting system (HP:0004742)	1.98143159
84	Abnormality of the preputium (HP:0100587)	1.96922162
85	Bundle branch block (HP:0011710)	1.93979845
86	Abnormal ciliary motility (HP:0012262)	1.93880452
87	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.92334637
88	Stillbirth (HP:0003826)	1.92234439
89	Abnormality of the ileum (HP:0001549)	1.90219243
90	Abnormality of DNA repair (HP:0003254)	1.89805755
91	Hydroureter (HP:0000072)	1.88554603
92	Supranuclear gaze palsy (HP:0000605)	1.87874592
93	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.87715709
94	Subcapsular cataract (HP:0000523)	1.87689073
95	Increased circulating renin level (HP:0000848)	1.87379018
96	Sensory axonal neuropathy (HP:0003390)	1.85852791
97	Secondary amenorrhea (HP:0000869)	1.85656648
98	Duplicated collecting system (HP:0000081)	1.85234395
99	Nephroblastoma (Wilms tumor) (HP:0002667)	1.85010877
100	Abnormality of the phalanges of the hallux (HP:0010057)	1.82442953

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.56085588
2	MAP3K13	6.21571866
3	ARAF	6.01150270
4	CDK12	3.12660238
5	STK24	3.07398699
6	TAOK3	3.00491301
7	NEK6	2.89779933
8	BRAF	2.88573826
9	TTK	2.80541991
10	MOS	2.68201106
11	KSR2	2.29818827
12	AURKA	2.26394653
13	MET	2.22455807
14	CDK9	1.93674492
15	RAF1	1.92837516
16	CDC7	1.87136767
17	NTRK2	1.68129765
18	EIF2AK3	1.45264165
19	PRKCI	1.43248883
20	KSR1	1.38256020
21	CDK7	1.35686243
22	TNIK	1.34953987
23	BUB1	1.33123377
24	STK3	1.30966964
25	TRIM28	1.28873901
26	MELK	1.27017602
27	PLK1	1.24767679
28	PTK2	1.09199870
29	MAP3K8	1.05280020
30	BRSK1	1.03376164
31	PIM1	0.97480436
32	NEK2	0.92610021
33	ZAK	0.88681865
34	NTRK3	0.87587094
35	CHEK1	0.87433648
36	NUAK1	0.85975170
37	TNK2	0.74668155
38	MST4	0.74158992
39	WNK1	0.73413204
40	CDK2	0.70658434
41	CSNK1G1	0.67197499
42	PLK3	0.66291121
43	TGFBR1	0.64733605
44	TIE1	0.62865914
45	MARK3	0.62413382
46	CHEK2	0.61233379
47	MAPKAPK3	0.61210060
48	CDK8	0.59850511
49	BMPR1B	0.59187009
50	AURKB	0.57652423
51	ATM	0.56933770
52	PAK1	0.53773557
53	PRKG1	0.52598871
54	MAP3K4	0.52088254
55	DMPK	0.49378082
56	CAMK1D	0.49139311
57	MTOR	0.48962204
58	CDK19	0.48671122
59	NEK9	0.48024255
60	CSNK1D	0.47401122
61	CDK1	0.46414686
62	LATS1	0.45430255
63	CSNK1G3	0.44806490
64	GRK1	0.43863042
65	STK39	0.43734586
66	EEF2K	0.43074459
67	BRSK2	0.41572164
68	PRKCZ	0.40031574
69	PKN1	0.38130246
70	BRD4	0.37703917
71	MAP3K1	0.37375830
72	LRRK2	0.37035898
73	MAPK13	0.35044628
74	PRKACB	0.34380123
75	CDK5	0.34242328
76	TLK1	0.33617208
77	ATR	0.32592539
78	VRK1	0.31005132
79	MAP3K5	0.30468529
80	CSNK1E	0.28969382
81	AKT2	0.28750315
82	CSNK1A1L	0.28548069
83	PDK1	0.27232480
84	PBK	0.26991229
85	CAMK2A	0.25895987
86	GSK3B	0.25723341
87	TRPM7	0.23914125
88	PRKACA	0.23834561
89	MAPK1	0.23304286
90	MAPK10	0.22154188
91	CHUK	0.21900080
92	LMTK2	0.21263395
93	CSNK1G2	0.21157459
94	CAMK1G	0.20931355
95	TYRO3	0.20307047
96	ACVR1B	0.19029255
97	MAP2K1	0.17315706
98	EGFR	0.15504060
99	EPHA4	0.11769524
100	TESK2	0.10386002

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.27040765
2	Cell cycle_Homo sapiens_hsa04110	4.44513686
3	Ovarian steroidogenesis_Homo sapiens_hsa04913	4.01669425
4	Mismatch repair_Homo sapiens_hsa03430	3.73397506
5	Oocyte meiosis_Homo sapiens_hsa04114	3.36277871
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.25817735
7	Base excision repair_Homo sapiens_hsa03410	3.03787508
8	Caffeine metabolism_Homo sapiens_hsa00232	2.98299665
9	RNA degradation_Homo sapiens_hsa03018	2.88721744
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.77981302
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.65590433
12	DNA replication_Homo sapiens_hsa03030	2.33828421
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29543396
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.29417132
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.11062630
16	Olfactory transduction_Homo sapiens_hsa04740	2.05386974
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.04354369
18	Homologous recombination_Homo sapiens_hsa03440	1.95728499
19	Circadian rhythm_Homo sapiens_hsa04710	1.79812048
20	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.77963516
21	RNA transport_Homo sapiens_hsa03013	1.76785631
22	p53 signaling pathway_Homo sapiens_hsa04115	1.68464782
23	Gap junction_Homo sapiens_hsa04540	1.63903450
24	Thyroid cancer_Homo sapiens_hsa05216	1.57390345
25	Phototransduction_Homo sapiens_hsa04744	1.53185262
26	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.22555050
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.21504039
28	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.14552760
29	Folate biosynthesis_Homo sapiens_hsa00790	1.14068783
30	RNA polymerase_Homo sapiens_hsa03020	1.13852008
31	ABC transporters_Homo sapiens_hsa02010	1.11813343
32	mRNA surveillance pathway_Homo sapiens_hsa03015	1.11577744
33	Nicotine addiction_Homo sapiens_hsa05033	1.06203459
34	GABAergic synapse_Homo sapiens_hsa04727	0.95400684
35	Bile secretion_Homo sapiens_hsa04976	0.94371828
36	Morphine addiction_Homo sapiens_hsa05032	0.94258715
37	mTOR signaling pathway_Homo sapiens_hsa04150	0.93655056
38	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.89977658
39	Taste transduction_Homo sapiens_hsa04742	0.89221722
40	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.81482849
41	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73295410
42	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.71142449
43	Fatty acid elongation_Homo sapiens_hsa00062	0.69155170
44	Serotonergic synapse_Homo sapiens_hsa04726	0.67652386
45	Long-term depression_Homo sapiens_hsa04730	0.65897179
46	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.64385404
47	FoxO signaling pathway_Homo sapiens_hsa04068	0.62208422
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55730317
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54610222
50	MicroRNAs in cancer_Homo sapiens_hsa05206	0.54530050
51	Adherens junction_Homo sapiens_hsa04520	0.53997555
52	Viral carcinogenesis_Homo sapiens_hsa05203	0.52162217
53	Purine metabolism_Homo sapiens_hsa00230	0.47818418
54	Herpes simplex infection_Homo sapiens_hsa05168	0.45833655
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43263009
56	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.42646785
57	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41260832
58	Small cell lung cancer_Homo sapiens_hsa05222	0.40075019
59	Notch signaling pathway_Homo sapiens_hsa04330	0.39407492
60	ErbB signaling pathway_Homo sapiens_hsa04012	0.34663322
61	HTLV-I infection_Homo sapiens_hsa05166	0.30751328
62	Ras signaling pathway_Homo sapiens_hsa04014	0.30570604
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.30351879
64	Arginine biosynthesis_Homo sapiens_hsa00220	0.30022311
65	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.28447993
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.27422055
67	Hippo signaling pathway_Homo sapiens_hsa04390	0.27261830
68	Wnt signaling pathway_Homo sapiens_hsa04310	0.26490331
69	Protein digestion and absorption_Homo sapiens_hsa04974	0.26040376
70	Lysine degradation_Homo sapiens_hsa00310	0.22762583
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.22102207
72	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.21423115
73	Circadian entrainment_Homo sapiens_hsa04713	0.20878101
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20641444
75	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.20225579
76	Huntingtons disease_Homo sapiens_hsa05016	0.20046369
77	Cholinergic synapse_Homo sapiens_hsa04725	0.19342639
78	Phagosome_Homo sapiens_hsa04145	0.18548782
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.18391626
80	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.16774296
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.16703942
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.15874742
83	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.15612743
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.15476778
85	Endometrial cancer_Homo sapiens_hsa05213	0.15334278
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.14665292
87	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.13831558
88	Regulation of autophagy_Homo sapiens_hsa04140	0.13766080
89	Propanoate metabolism_Homo sapiens_hsa00640	0.11923036
90	Tight junction_Homo sapiens_hsa04530	0.09559265
91	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.08852114
92	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.08413740
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.08365690
94	Long-term potentiation_Homo sapiens_hsa04720	0.07751624
95	Hepatitis B_Homo sapiens_hsa05161	0.07331311
96	Renal cell carcinoma_Homo sapiens_hsa05211	0.07185308
97	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.06906041
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.06876089
99	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.06827430
100	Chemokine signaling pathway_Homo sapiens_hsa04062	0.06644567

TUBB8P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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