ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acrosome reaction (GO:0060046)	9.92421748
2	multicellular organism reproduction (GO:0032504)	7.76928507
3	oocyte development (GO:0048599)	7.52557829
4	meiotic cell cycle (GO:0051321)	6.90763039
5	negative regulation of reproductive process (GO:2000242)	6.59742063
6	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	6.46477715
7	piRNA metabolic process (GO:0034587)	6.44582264
8	protein kinase C signaling (GO:0070528)	6.40331025
9	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.06209478
10	DNA methylation involved in gamete generation (GO:0043046)	6.05322410
11	regulation of meiosis I (GO:0060631)	6.01619427
12	regulation of histone H3-K9 methylation (GO:0051570)	5.95538269
13	female gamete generation (GO:0007292)	5.95341479
14	positive regulation of humoral immune response (GO:0002922)	5.56636779
15	regulation of retinoic acid receptor signaling pathway (GO:0048385)	5.53804116
16	retinal cone cell development (GO:0046549)	5.50149793
17	positive regulation of histone H3-K4 methylation (GO:0051571)	5.47187971
18	positive regulation of gastrulation (GO:2000543)	5.21039141
19	reproduction (GO:0000003)	5.09275439
20	glycine transport (GO:0015816)	5.06123072
21	binding of sperm to zona pellucida (GO:0007339)	4.99887768
22	regulation of steroid hormone secretion (GO:2000831)	4.85531157
23	negative regulation of histone methylation (GO:0031061)	4.80549560
24	mitotic metaphase plate congression (GO:0007080)	4.79883695
25	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.72054201
26	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.72054201
27	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.72054201
28	positive regulation of reproductive process (GO:2000243)	4.71266906
29	regulation of cell maturation (GO:1903429)	4.46860253
30	regulation of penile erection (GO:0060405)	4.41229998
31	positive regulation of chromosome segregation (GO:0051984)	4.21617860
32	establishment of chromosome localization (GO:0051303)	4.17480101
33	gene silencing by RNA (GO:0031047)	4.13725406
34	citrulline biosynthetic process (GO:0019240)	4.12767262
35	primitive streak formation (GO:0090009)	4.06276349
36	fertilization (GO:0009566)	4.03894734
37	protein localization to chromosome, centromeric region (GO:0071459)	4.00381097
38	centriole replication (GO:0007099)	4.00267406
39	regulation of reproductive process (GO:2000241)	3.91821440
40	metaphase plate congression (GO:0051310)	3.90274575
41	single fertilization (GO:0007338)	3.89389330
42	CENP-A containing nucleosome assembly (GO:0034080)	3.81673287
43	regulation of phospholipid biosynthetic process (GO:0071071)	3.81452567
44	sperm-egg recognition (GO:0035036)	3.77346482
45	mitotic chromosome condensation (GO:0007076)	3.76888710
46	protein localization to kinetochore (GO:0034501)	3.75315027
47	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.64407775
48	male meiosis I (GO:0007141)	3.62895370
49	regulation of chromatin binding (GO:0035561)	3.58944452
50	negative regulation of cAMP-mediated signaling (GO:0043951)	3.54845804
51	chromatin remodeling at centromere (GO:0031055)	3.52256431
52	synaptonemal complex assembly (GO:0007130)	3.51842743
53	regulation of meiosis (GO:0040020)	3.49448957
54	synapsis (GO:0007129)	3.41934343
55	interkinetic nuclear migration (GO:0022027)	3.38840311
56	positive regulation of histone methylation (GO:0031062)	3.38686262
57	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.36353592
58	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.35178937
59	DNA alkylation (GO:0006305)	3.31035809
60	DNA methylation (GO:0006306)	3.31035809
61	oogenesis (GO:0048477)	3.29120773
62	protein localization to chromosome (GO:0034502)	3.27539430
63	regulation of DNA endoreduplication (GO:0032875)	3.22573869
64	meiosis I (GO:0007127)	3.17784777
65	neuron fate determination (GO:0048664)	3.12970815
66	synaptonemal complex organization (GO:0070193)	3.12843745
67	chromosome organization involved in meiosis (GO:0070192)	3.11102233
68	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.10263088
69	regulation of hypersensitivity (GO:0002883)	3.09550315
70	regulation of histone H3-K4 methylation (GO:0051569)	3.05998900
71	attachment of spindle microtubules to kinetochore (GO:0008608)	3.01991484
72	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.00978665
73	regulation of spindle organization (GO:0090224)	2.98808426
74	regulation of steroid hormone biosynthetic process (GO:0090030)	2.97988432
75	epithelial cilium movement (GO:0003351)	2.94808940
76	regulation of chromatin silencing (GO:0031935)	2.94705536
77	negative regulation of muscle hypertrophy (GO:0014741)	2.93465303
78	meiotic cell cycle process (GO:1903046)	2.92053276
79	N-terminal protein amino acid acetylation (GO:0006474)	2.91282057
80	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.90715220
81	positive regulation of endothelial cell differentiation (GO:0045603)	2.90032487
82	histone exchange (GO:0043486)	2.89491106
83	relaxation of smooth muscle (GO:0044557)	2.89055329
84	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.88526694
85	cell-cell recognition (GO:0009988)	2.88120910
86	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.88046024
87	translesion synthesis (GO:0019985)	2.88028815
88	aggressive behavior (GO:0002118)	2.86763605
89	meiotic nuclear division (GO:0007126)	2.86378151
90	male meiosis (GO:0007140)	2.86278890
91	negative regulation of gene silencing (GO:0060969)	2.85531667
92	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.84565058
93	regulation of histone methylation (GO:0031060)	2.84181449
94	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	2.82821005
95	regulation of meiotic cell cycle (GO:0051445)	2.82423435
96	labyrinthine layer development (GO:0060711)	2.81570845
97	positive regulation of meiosis (GO:0045836)	2.80351803
98	regulation of female receptivity (GO:0045924)	2.76663583
99	regulation of female gonad development (GO:2000194)	10.4582727
100	regulation of DNA methylation (GO:0044030)	10.0912357

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.86644491
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.84595648
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.66579555
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.73154542
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.99926728
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.99926728
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.99926728
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.42080683
9	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.38948113
10	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.37163288
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.29533194
12	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.28969661
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20040074
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.17604506
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.17297346
16	EZH2_22144423_ChIP-Seq_EOC_Human	14.7934699
17	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.97772623
18	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.84175092
19	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.64272672
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61285332
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.60782042
22	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.57865182
23	E2F7_22180533_ChIP-Seq_HELA_Human	1.33991724
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.32833736
25	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.29915717
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.26227771
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23667137
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.22723223
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.20849772
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19974896
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19974896
32	EWS_26573619_Chip-Seq_HEK293_Human	1.19364883
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18982916
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17122605
35	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16727963
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.15906485
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12641734
38	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.08025206
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.05879890
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05879890
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05728730
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03568054
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00195231
44	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99657659
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.97793733
46	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97217305
47	P300_19829295_ChIP-Seq_ESCs_Human	0.96814541
48	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.96098363
49	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.95639172
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.93721466
51	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93499709
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92042789
53	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91505511
54	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91224427
55	AR_25329375_ChIP-Seq_VCAP_Human	0.91037589
56	CBP_21632823_ChIP-Seq_H3396_Human	0.89690385
57	REST_21632747_ChIP-Seq_MESCs_Mouse	0.89220447
58	AHR_22903824_ChIP-Seq_MCF-7_Human	0.88420923
59	TCF4_23295773_ChIP-Seq_U87_Human	0.88092915
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.86656407
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85987779
62	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.85192391
63	GF1_26923725_Chip-Seq_HPCs_Mouse	0.84750964
64	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.83827060
65	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.83817942
66	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.81212355
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.80732387
68	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.79536071
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.77567215
70	FUS_26573619_Chip-Seq_HEK293_Human	0.77158462
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.77140607
72	ZNF274_21170338_ChIP-Seq_K562_Hela	0.76644571
73	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.75758199
74	RUNX2_22187159_ChIP-Seq_PCA_Human	0.75393622
75	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.74407188
76	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.73889310
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.72695767
78	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.72107072
79	VDR_22108803_ChIP-Seq_LS180_Human	0.71640424
80	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.70766833
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.70762129
82	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.70605481
83	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.69439222
84	TAF15_26573619_Chip-Seq_HEK293_Human	0.69360188
85	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.69102514
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.67725373
87	STAT3_23295773_ChIP-Seq_U87_Human	0.67711562
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.67403001
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.67181345
90	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.66801456
91	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.66777082
92	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.65706793
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.63899531
94	MYC_18940864_ChIP-ChIP_HL60_Human	0.63361498
95	TP53_22573176_ChIP-Seq_HFKS_Human	0.63264200
96	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.62984844
97	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.62862714
98	AR_21909140_ChIP-Seq_LNCAP_Human	0.62821614
99	RXR_22108803_ChIP-Seq_LS180_Human	0.62420230
100	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.59678505

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	7.90301350
2	MP0006292_abnormal_olfactory_placode	4.63486894
3	MP0008789_abnormal_olfactory_epithelium	4.08973488
4	MP0008877_abnormal_DNA_methylation	3.60770713
5	MP0005499_abnormal_olfactory_system	3.55017006
6	MP0005394_taste/olfaction_phenotype	3.55017006
7	MP0010030_abnormal_orbit_morphology	3.10512402
8	MP0005395_other_phenotype	2.89922790
9	MP0003890_abnormal_embryonic-extraembry	2.65366735
10	MP0002138_abnormal_hepatobiliary_system	2.64463466
11	MP0002234_abnormal_pharynx_morphology	2.48189416
12	MP0003699_abnormal_female_reproductive	2.43525577
13	MP0003693_abnormal_embryo_hatching	2.25577205
14	MP0002139_abnormal_hepatobiliary_system	2.23978562
15	MP0001929_abnormal_gametogenesis	2.14437875
16	MP0002210_abnormal_sex_determination	2.05315303
17	MP0002160_abnormal_reproductive_system	2.00218806
18	MP0003879_abnormal_hair_cell	1.85204112
19	MP0003077_abnormal_cell_cycle	1.75437743
20	MP0010368_abnormal_lymphatic_system	1.74713294
21	MP0003950_abnormal_plasma_membrane	1.73966733
22	MP0000566_synostosis	1.73864678
23	MP0000049_abnormal_middle_ear	1.73164439
24	MP0008058_abnormal_DNA_repair	1.73162588
25	MP0005647_abnormal_sex_gland	1.71130173
26	MP0000653_abnormal_sex_gland	1.66486737
27	MP0005360_urolithiasis	1.63696486
28	MP0002161_abnormal_fertility/fecundity	1.59297414
29	MP0005389_reproductive_system_phenotype	1.54853581
30	MP0000569_abnormal_digit_pigmentation	1.54186516
31	MP0000631_abnormal_neuroendocrine_gland	1.52828773
32	MP0008932_abnormal_embryonic_tissue	1.48455210
33	MP0008057_abnormal_DNA_replication	1.46540883
34	MP0001293_anophthalmia	1.45969920
35	MP0010094_abnormal_chromosome_stability	1.45477523
36	MP0000762_abnormal_tongue_morphology	1.44235217
37	MP0010234_abnormal_vibrissa_follicle	1.41911683
38	MP0005646_abnormal_pituitary_gland	1.41280614
39	MP0001119_abnormal_female_reproductive	1.38524726
40	MP0005410_abnormal_fertilization	1.36820906
41	MP0002272_abnormal_nervous_system	1.31469076
42	MP0003119_abnormal_digestive_system	1.29389600
43	MP0001730_embryonic_growth_arrest	1.27124869
44	MP0003121_genomic_imprinting	1.26731644
45	MP0002233_abnormal_nose_morphology	1.26144606
46	MP0003111_abnormal_nucleus_morphology	1.23325807
47	MP0001986_abnormal_taste_sensitivity	1.21390285
48	MP0001145_abnormal_male_reproductive	1.21137905
49	MP0001984_abnormal_olfaction	1.13228648
50	MP0002089_abnormal_postnatal_growth/wei	1.09307697
51	MP0005409_darkened_coat_color	1.07877099
52	MP0004142_abnormal_muscle_tone	1.06043819
53	MP0003698_abnormal_male_reproductive	1.01523189
54	MP0009379_abnormal_foot_pigmentation	0.98774737
55	MP0003252_abnormal_bile_duct	0.96804509
56	MP0010307_abnormal_tumor_latency	0.92521545
57	MP0001672_abnormal_embryogenesis/_devel	0.91894759
58	MP0005380_embryogenesis_phenotype	0.91894759
59	MP0000350_abnormal_cell_proliferation	0.89243953
60	MP0002751_abnormal_autonomic_nervous	0.89107508
61	MP0006072_abnormal_retinal_apoptosis	0.88673989
62	MP0002127_abnormal_cardiovascular_syste	0.85129041
63	MP0006276_abnormal_autonomic_nervous	0.84008597
64	MP0001502_abnormal_circadian_rhythm	0.83416838
65	MP0005551_abnormal_eye_electrophysiolog	0.80098908
66	MP0003136_yellow_coat_color	0.79440742
67	MP0003935_abnormal_craniofacial_develop	0.79425996
68	MP0003959_abnormal_lean_body	0.77116029
69	MP0000428_abnormal_craniofacial_morphol	0.75726894
70	MP0009250_abnormal_appendicular_skeleto	0.75681067
71	MP0000427_abnormal_hair_cycle	0.74947535
72	MP0004134_abnormal_chest_morphology	0.74913340
73	MP0001919_abnormal_reproductive_system	0.74853936
74	MP0010678_abnormal_skin_adnexa	0.74798027
75	MP0005423_abnormal_somatic_nervous	0.74780238
76	MP0002928_abnormal_bile_duct	0.73233331
77	MP0004957_abnormal_blastocyst_morpholog	0.71253861
78	MP0002735_abnormal_chemical_nociception	0.69196850
79	MP0002734_abnormal_mechanical_nocicepti	0.68816055
80	MP0000733_abnormal_muscle_development	0.68380495
81	MP0002084_abnormal_developmental_patter	0.67955672
82	MP0000678_abnormal_parathyroid_gland	0.67741773
83	MP0009840_abnormal_foam_cell	0.67462157
84	MP0001286_abnormal_eye_development	0.67193134
85	MP0003183_abnormal_peptide_metabolism	0.66296892
86	MP0005174_abnormal_tail_pigmentation	0.65926969
87	MP0003755_abnormal_palate_morphology	0.65008562
88	MP0002095_abnormal_skin_pigmentation	0.63765935
89	MP0000026_abnormal_inner_ear	0.61892138
90	MP0004270_analgesia	0.61729476
91	MP0009745_abnormal_behavioral_response	0.61541625
92	MP0003635_abnormal_synaptic_transmissio	0.61343368
93	MP0001666_abnormal_nutrient_absorption	0.61215124
94	MP0002085_abnormal_embryonic_tissue	0.61045447
95	MP0001963_abnormal_hearing_physiology	0.60768460
96	MP0004885_abnormal_endolymph	0.59218161
97	MP0002177_abnormal_outer_ear	0.58634748
98	MP0003861_abnormal_nervous_system	0.57417541
99	MP0002116_abnormal_craniofacial_bone	0.56825439
100	MP0001697_abnormal_embryo_size	0.53851197

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	5.26673807
2	Abdominal situs inversus (HP:0003363)	4.67013600
3	Abnormality of abdominal situs (HP:0011620)	4.67013600
4	Septo-optic dysplasia (HP:0100842)	4.58070403
5	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.44816032
6	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.20167496
7	Hypoplasia of the fovea (HP:0007750)	4.20167496
8	Short tibia (HP:0005736)	4.16615185
9	Anterior segment dysgenesis (HP:0007700)	3.95220181
10	Conjunctival hamartoma (HP:0100780)	3.84682023
11	Cholecystitis (HP:0001082)	3.75384175
12	Abnormal gallbladder physiology (HP:0012438)	3.75384175
13	Absent septum pellucidum (HP:0001331)	3.74303399
14	Facial hemangioma (HP:0000329)	3.73807880
15	Osteomalacia (HP:0002749)	3.71834435
16	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.69951326
17	Lip pit (HP:0100267)	3.68195247
18	Gonadotropin excess (HP:0000837)	3.65215160
19	Infertility (HP:0000789)	3.54056216
20	Male infertility (HP:0003251)	3.52650367
21	Abnormality of the fovea (HP:0000493)	3.46287661
22	Premature ovarian failure (HP:0008209)	3.42666332
23	Abnormality of the septum pellucidum (HP:0007375)	3.32891821
24	Median cleft lip (HP:0000161)	3.25256008
25	Papillary thyroid carcinoma (HP:0002895)	3.24115140
26	Oligodactyly (hands) (HP:0001180)	3.23824366
27	Impulsivity (HP:0100710)	3.09347724
28	Abnormal ciliary motility (HP:0012262)	3.03848346
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.91585591
30	Hypergonadotropic hypogonadism (HP:0000815)	2.89248693
31	Skin pits (HP:0100276)	2.84081560
32	Hypophosphatemic rickets (HP:0004912)	2.80120804
33	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.73056616
34	Apathy (HP:0000741)	2.67864792
35	Abnormal respiratory motile cilium physiology (HP:0012261)	2.61526971
36	Hypokinesia (HP:0002375)	2.61377128
37	Abnormality of the labia minora (HP:0012880)	2.51903639
38	Chromsome breakage (HP:0040012)	2.50681953
39	Hamartoma of the eye (HP:0010568)	2.49859606
40	Myokymia (HP:0002411)	2.49536690
41	Aplasia/Hypoplasia of the macula (HP:0008059)	2.48756186
42	Azoospermia (HP:0000027)	2.45509875
43	Diminished motivation (HP:0000745)	2.45186250
44	Abnormal biliary tract physiology (HP:0012439)	2.43999622
45	Bile duct proliferation (HP:0001408)	2.43999622
46	Preauricular pit (HP:0004467)	2.42980911
47	Periauricular skin pits (HP:0100277)	2.42980911
48	Secondary amenorrhea (HP:0000869)	2.39403167
49	Maternal diabetes (HP:0009800)	2.38480120
50	Enlarged penis (HP:0000040)	2.35141006
51	Abnormal lung lobation (HP:0002101)	2.30438001
52	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.29270458
53	Abnormality of midbrain morphology (HP:0002418)	2.27790395
54	Molar tooth sign on MRI (HP:0002419)	2.27790395
55	Oligodactyly (HP:0012165)	2.25335237
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.23421565
57	Wrist flexion contracture (HP:0001239)	2.21691550
58	Malnutrition (HP:0004395)	2.18704970
59	Aplasia of the musculature (HP:0100854)	2.15514462
60	Rhinitis (HP:0012384)	2.14883489
61	Sensory axonal neuropathy (HP:0003390)	2.11998190
62	Severe visual impairment (HP:0001141)	2.11479165
63	Hypoplastic pelvis (HP:0008839)	2.09967446
64	Meningioma (HP:0002858)	2.03496114
65	Stillbirth (HP:0003826)	1.98644280
66	Abnormal spermatogenesis (HP:0008669)	1.97373350
67	Capillary hemangiomas (HP:0005306)	1.97031014
68	Posterior subcapsular cataract (HP:0007787)	1.95857758
69	Abnormality of the anterior chamber (HP:0000593)	1.95103658
70	Microglossia (HP:0000171)	1.91917975
71	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.91338192
72	Congenital sensorineural hearing impairment (HP:0008527)	1.88855477
73	Abnormality of the preputium (HP:0100587)	1.88146494
74	Hypoplasia of the uterus (HP:0000013)	1.88087629
75	Abnormality of the phalanges of the hallux (HP:0010057)	1.86764943
76	Cleft eyelid (HP:0000625)	1.86433465
77	Urethral obstruction (HP:0000796)	1.83808164
78	Thyroid carcinoma (HP:0002890)	1.83011419
79	Muscle stiffness (HP:0003552)	1.81822058
80	Meckel diverticulum (HP:0002245)	1.81691269
81	Esotropia (HP:0000565)	1.81363284
82	Pendular nystagmus (HP:0012043)	1.78321295
83	Anomalous pulmonary venous return (HP:0010772)	1.78122126
84	Obstructive sleep apnea (HP:0002870)	1.76051671
85	Truncal obesity (HP:0001956)	1.75477313
86	Absent/shortened dynein arms (HP:0200106)	1.72961875
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72961875
88	Intrahepatic cholestasis (HP:0001406)	1.71761964
89	Abnormality of the ileum (HP:0001549)	1.71016405
90	Pancreatic cysts (HP:0001737)	1.70870050
91	Abnormality of chromosome stability (HP:0003220)	1.69509479
92	Abnormality of the pons (HP:0007361)	1.69405103
93	Preaxial hand polydactyly (HP:0001177)	1.67423305
94	Spinal canal stenosis (HP:0003416)	1.66448409
95	Synostosis of carpal bones (HP:0005048)	1.66198153
96	Action tremor (HP:0002345)	1.65825306
97	Optic nerve hypoplasia (HP:0000609)	1.65312988
98	Adenoma sebaceum (HP:0009720)	1.63609287
99	Angiofibromas (HP:0010615)	1.63609287
100	Small intestinal stenosis (HP:0012848)	1.62551793

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	4.62981227
2	MAP3K9	4.49616245
3	NME2	3.65968013
4	MAP3K13	3.22609554
5	NEK6	3.15140704
6	AURKA	2.80201750
7	CDK9	2.48342896
8	TESK2	2.44120763
9	CDK12	2.41326693
10	BUB1	2.38010825
11	TTK	2.37194964
12	STK24	2.29055776
13	MELK	2.23003516
14	TAOK3	2.16921258
15	BRAF	2.15209899
16	MOS	2.14659508
17	TNIK	2.11257853
18	BMPR1B	1.91703001
19	MET	1.91412976
20	NEK9	1.89431754
21	NTRK2	1.88163324
22	VRK2	1.80613492
23	NUAK1	1.70161667
24	TRIM28	1.65608885
25	PRKCI	1.54469931
26	MAPKAPK3	1.51240362
27	CDK7	1.48410448
28	CCNB1	1.46290304
29	CSNK1G1	1.45094644
30	CDC7	1.42971769
31	RAF1	1.40220722
32	PLK1	1.36534317
33	STK16	1.30486160
34	BRSK1	1.30369671
35	CSNK1G3	1.26302954
36	CDK19	1.25893036
37	KSR2	1.12847008
38	ACVR1B	1.09777516
39	CSNK1G2	1.08723863
40	CSNK1A1L	1.06632692
41	WNK1	0.98644200
42	CHEK1	0.95617587
43	VRK1	0.87852568
44	TGFBR1	0.83256092
45	MAP3K8	0.83118926
46	EIF2AK3	0.81146273
47	SRPK1	0.79536851
48	PLK3	0.77609201
49	MST4	0.76204990
50	AURKB	0.72850697
51	PTK2	0.72541410
52	TLK1	0.71902053
53	ERBB4	0.70758060
54	NEK2	0.69380004
55	MAP2K7	0.69208922
56	PIM1	0.67923591
57	CHEK2	0.67122622
58	STK3	0.66550322
59	CDK2	0.65933795
60	BRD4	0.63593764
61	LMTK2	0.59436904
62	CDK8	0.59069980
63	MAPK13	0.55971967
64	CSNK1D	0.55384234
65	CAMK1D	0.53692367
66	KSR1	0.52566036
67	TIE1	0.52516178
68	DMPK	0.50450478
69	CDK1	0.49815952
70	PRKG1	0.49042970
71	PAK1	0.48728666
72	LATS2	0.45701590
73	NTRK3	0.45645897
74	RPS6KB2	0.45571240
75	MAP3K4	0.44043490
76	ATM	0.43968352
77	MUSK	0.41971620
78	MTOR	0.38994549
79	ATR	0.38535056
80	PRKACA	0.38267694
81	TESK1	0.37717668
82	PKN1	0.37113624
83	TNK2	0.36758264
84	PRKCZ	0.34582881
85	ICK	0.33766955
86	ZAK	0.33577468
87	MAPK11	0.32983516
88	MAPKAPK5	0.30933069
89	GSK3B	0.30752119
90	CDK5	0.30462714
91	DAPK1	0.30335146
92	EIF2AK2	0.30050226
93	PRKACB	0.29553279
94	AKT2	0.26982694
95	GSK3A	0.26403961
96	CSNK1E	0.25800251
97	STK39	0.25079928
98	BRSK2	0.23345094
99	MARK3	0.22190596
100	CAMK2A	0.21050178

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.78868909
2	Cell cycle_Homo sapiens_hsa04110	3.67025714
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.40825712
4	Oocyte meiosis_Homo sapiens_hsa04114	3.23367118
5	Mismatch repair_Homo sapiens_hsa03430	3.05423449
6	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.05064420
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.86222763
8	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.56250948
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.46830636
10	RNA degradation_Homo sapiens_hsa03018	2.46771744
11	Homologous recombination_Homo sapiens_hsa03440	2.29132724
12	RNA transport_Homo sapiens_hsa03013	2.20497561
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.14000141
14	Caffeine metabolism_Homo sapiens_hsa00232	2.06731554
15	Folate biosynthesis_Homo sapiens_hsa00790	2.06124390
16	Nucleotide excision repair_Homo sapiens_hsa03420	2.03545038
17	RNA polymerase_Homo sapiens_hsa03020	1.95450704
18	Base excision repair_Homo sapiens_hsa03410	1.95009066
19	DNA replication_Homo sapiens_hsa03030	1.94488150
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.93236259
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.93063092
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.72212667
23	p53 signaling pathway_Homo sapiens_hsa04115	1.71885323
24	Olfactory transduction_Homo sapiens_hsa04740	1.68955667
25	Gap junction_Homo sapiens_hsa04540	1.64204607
26	mRNA surveillance pathway_Homo sapiens_hsa03015	1.55548434
27	Circadian rhythm_Homo sapiens_hsa04710	1.52589329
28	Nicotine addiction_Homo sapiens_hsa05033	1.31631088
29	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.30971459
30	Huntingtons disease_Homo sapiens_hsa05016	1.19063075
31	Ribosome_Homo sapiens_hsa03010	1.16602135
32	Morphine addiction_Homo sapiens_hsa05032	1.11009654
33	Spliceosome_Homo sapiens_hsa03040	1.08788138
34	Phototransduction_Homo sapiens_hsa04744	1.01660978
35	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.98731630
36	GABAergic synapse_Homo sapiens_hsa04727	0.96526589
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.94965972
38	mTOR signaling pathway_Homo sapiens_hsa04150	0.93658837
39	Regulation of autophagy_Homo sapiens_hsa04140	0.88520830
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87135306
41	Arginine biosynthesis_Homo sapiens_hsa00220	0.86654678
42	Wnt signaling pathway_Homo sapiens_hsa04310	0.85855422
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83996585
44	Taste transduction_Homo sapiens_hsa04742	0.80361929
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.77149141
46	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.76076744
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75365636
48	MicroRNAs in cancer_Homo sapiens_hsa05206	0.73339151
49	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.70929950
50	Purine metabolism_Homo sapiens_hsa00230	0.68931846
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65103673
52	Thyroid cancer_Homo sapiens_hsa05216	0.60545444
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.60350390
54	Melanoma_Homo sapiens_hsa05218	0.59504867
55	Hippo signaling pathway_Homo sapiens_hsa04390	0.58720400
56	Fatty acid elongation_Homo sapiens_hsa00062	0.56930475
57	Long-term depression_Homo sapiens_hsa04730	0.56428268
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51318843
59	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50706312
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.48349836
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.47925005
62	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.46941009
63	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.46262874
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.45000285
65	Insulin secretion_Homo sapiens_hsa04911	0.43869147
66	ABC transporters_Homo sapiens_hsa02010	0.43787017
67	Cholinergic synapse_Homo sapiens_hsa04725	0.43705675
68	Serotonergic synapse_Homo sapiens_hsa04726	0.42817306
69	Adherens junction_Homo sapiens_hsa04520	0.42809120
70	Parkinsons disease_Homo sapiens_hsa05012	0.42323836
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.42144954
72	Gastric acid secretion_Homo sapiens_hsa04971	0.41186796
73	Salivary secretion_Homo sapiens_hsa04970	0.39222594
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38741262
75	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38330980
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.37821013
77	Herpes simplex infection_Homo sapiens_hsa05168	0.36834404
78	Viral carcinogenesis_Homo sapiens_hsa05203	0.36750527
79	Long-term potentiation_Homo sapiens_hsa04720	0.36077351
80	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.35712521
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.34683452
82	Circadian entrainment_Homo sapiens_hsa04713	0.33963227
83	Tight junction_Homo sapiens_hsa04530	0.32634348
84	Bile secretion_Homo sapiens_hsa04976	0.32019392
85	MAPK signaling pathway_Homo sapiens_hsa04010	0.27508834
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.27085503
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.25300971
88	Ras signaling pathway_Homo sapiens_hsa04014	0.24912179
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.24310480
90	Notch signaling pathway_Homo sapiens_hsa04330	0.23952270
91	ErbB signaling pathway_Homo sapiens_hsa04012	0.20797474
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.20377230
93	Amphetamine addiction_Homo sapiens_hsa05031	0.19862198
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.19697002
95	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.18720493
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.18482861
97	Rap1 signaling pathway_Homo sapiens_hsa04015	0.18388842
98	Oxidative phosphorylation_Homo sapiens_hsa00190	0.16363681
99	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.15840798
100	Melanogenesis_Homo sapiens_hsa04916	0.15265385

TUBB8P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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