ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	8.98668297
2	oocyte development (GO:0048599)	8.92023225
3	piRNA metabolic process (GO:0034587)	8.04308530
4	meiotic cell cycle (GO:0051321)	7.80469815
5	protein kinase C signaling (GO:0070528)	7.64533217
6	regulation of meiosis I (GO:0060631)	7.29383572
7	negative regulation of reproductive process (GO:2000242)	7.08913827
8	positive regulation of humoral immune response (GO:0002922)	7.08067512
9	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.77961821
10	DNA methylation involved in gamete generation (GO:0043046)	6.75710444
11	female gamete generation (GO:0007292)	6.62159066
12	regulation of histone H3-K9 methylation (GO:0051570)	6.58747578
13	positive regulation of histone H3-K4 methylation (GO:0051571)	6.58736277
14	retinal cone cell development (GO:0046549)	6.37636859
15	reproduction (GO:0000003)	6.01429037
16	regulation of steroid hormone secretion (GO:2000831)	5.70392482
17	negative regulation of histone methylation (GO:0031061)	5.63305692
18	glycine transport (GO:0015816)	5.48367974
19	regulation of cell maturation (GO:1903429)	5.29410436
20	mitotic chromosome condensation (GO:0007076)	5.24847799
21	citrulline biosynthetic process (GO:0019240)	5.24357452
22	binding of sperm to zona pellucida (GO:0007339)	5.13420242
23	gene silencing by RNA (GO:0031047)	5.00233867
24	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.96419956
25	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.96419956
26	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.96419956
27	positive regulation of gastrulation (GO:2000543)	4.68054267
28	protein localization to chromosome, centromeric region (GO:0071459)	4.67227896
29	protein localization to kinetochore (GO:0034501)	4.61967516
30	positive regulation of reproductive process (GO:2000243)	4.54349957
31	fertilization (GO:0009566)	4.51000840
32	positive regulation of chromosome segregation (GO:0051984)	4.39290948
33	regulation of hypersensitivity (GO:0002883)	4.29922655
34	single fertilization (GO:0007338)	4.28769240
35	mitotic metaphase plate congression (GO:0007080)	4.19107952
36	primitive streak formation (GO:0090009)	4.18103155
37	regulation of calcium ion-dependent exocytosis (GO:0017158)	4.12808990
38	positive regulation of histone methylation (GO:0031062)	4.08489419
39	centriole replication (GO:0007099)	4.05657180
40	synapsis (GO:0007129)	4.02356577
41	establishment of chromosome localization (GO:0051303)	3.98641019
42	sperm-egg recognition (GO:0035036)	3.98422178
43	regulation of meiosis (GO:0040020)	3.96946294
44	regulation of reproductive process (GO:2000241)	3.96923621
45	regulation of histone H3-K4 methylation (GO:0051569)	3.96307056
46	regulation of steroid hormone biosynthetic process (GO:0090030)	3.95774149
47	DNA methylation (GO:0006306)	3.94173166
48	DNA alkylation (GO:0006305)	3.94173166
49	regulation of phospholipid biosynthetic process (GO:0071071)	3.85869988
50	L-amino acid import (GO:0043092)	3.85799182
51	attachment of spindle microtubules to kinetochore (GO:0008608)	3.77450615
52	synaptonemal complex assembly (GO:0007130)	3.69916501
53	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.59918858
54	regulation of spindle organization (GO:0090224)	3.57786661
55	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.55865363
56	protein localization to chromosome (GO:0034502)	3.55233647
57	regulation of histone methylation (GO:0031060)	3.54947080
58	oogenesis (GO:0048477)	3.51906377
59	phosphorelay signal transduction system (GO:0000160)	3.51544482
60	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.47023842
61	chromosome organization involved in meiosis (GO:0070192)	3.46003459
62	male meiosis I (GO:0007141)	3.45184634
63	gene silencing (GO:0016458)	3.44963196
64	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.37689432
65	CENP-A containing nucleosome assembly (GO:0034080)	3.36941060
66	metaphase plate congression (GO:0051310)	3.36338327
67	N-terminal protein amino acid acetylation (GO:0006474)	3.36276647
68	regulation of chromatin silencing (GO:0031935)	3.30359272
69	negative regulation of hormone biosynthetic process (GO:0032353)	3.30062950
70	male meiosis (GO:0007140)	3.29438954
71	labyrinthine layer development (GO:0060711)	3.27862601
72	regulation of meiotic cell cycle (GO:0051445)	3.26168967
73	negative regulation of histone modification (GO:0031057)	3.25769664
74	synaptonemal complex organization (GO:0070193)	3.25584137
75	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.24555870
76	negative regulation of cAMP-mediated signaling (GO:0043951)	3.24396620
77	stress granule assembly (GO:0034063)	3.20620466
78	cell-cell recognition (GO:0009988)	3.19825220
79	interkinetic nuclear migration (GO:0022027)	3.17845019
80	negative regulation of hormone metabolic process (GO:0032351)	3.17443329
81	DNA replication-dependent nucleosome organization (GO:0034723)	3.17439376
82	DNA replication-dependent nucleosome assembly (GO:0006335)	3.17439376
83	negative regulation of execution phase of apoptosis (GO:1900118)	3.16144151
84	phosphatidylinositol dephosphorylation (GO:0046856)	3.15811749
85	histone H3-K9 demethylation (GO:0033169)	3.15627527
86	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.13578367
87	translesion synthesis (GO:0019985)	3.11688076
88	regulation of corticosteroid hormone secretion (GO:2000846)	3.08439724
89	meiotic cell cycle process (GO:1903046)	3.07375159
90	meiotic nuclear division (GO:0007126)	3.06452516
91	citrulline metabolic process (GO:0000052)	3.06291488
92	regulation of spindle checkpoint (GO:0090231)	3.05801896
93	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.05432140
94	somite rostral/caudal axis specification (GO:0032525)	3.03797470
95	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.03795943
96	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.02843192
97	chromatin remodeling at centromere (GO:0031055)	3.02690552
98	regulation of female gonad development (GO:2000194)	11.8067805
99	regulation of acrosome reaction (GO:0060046)	11.5499920
100	regulation of DNA methylation (GO:0044030)	10.5697956

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.68213994
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.27641564
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.16572450
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.41168224
5	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.87918295
6	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.87918295
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.87918295
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.67832527
9	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.64531055
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40635326
11	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.35363542
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.15320947
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.14574235
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.12763970
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.10012170
16	EZH2_22144423_ChIP-Seq_EOC_Human	16.5349939
17	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.91586439
18	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.89795024
19	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.71240237
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.68829204
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.65653441
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48469978
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45419041
24	AR_21909140_ChIP-Seq_LNCAP_Human	1.45179016
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.44771993
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41911430
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.37574323
28	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.36411823
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21691545
30	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13005206
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09525266
32	TCF4_23295773_ChIP-Seq_U87_Human	1.08710616
33	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07398990
34	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07044780
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.06504721
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06504721
37	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03367365
38	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99121858
39	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98033500
40	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97282703
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96719452
42	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.96156445
43	AR_25329375_ChIP-Seq_VCAP_Human	0.95994763
44	GF1_26923725_Chip-Seq_HPCs_Mouse	0.95927013
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95362783
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95362783
47	SMAD4_21799915_ChIP-Seq_A2780_Human	0.92831066
48	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.92127600
49	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.89573024
50	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.88570417
51	RUNX2_22187159_ChIP-Seq_PCA_Human	0.88171199
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87740859
53	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87727732
54	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84261864
55	CBP_21632823_ChIP-Seq_H3396_Human	0.82372256
56	STAT3_23295773_ChIP-Seq_U87_Human	0.79568639
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.78091175
58	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.76089252
59	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.76010555
60	KLF4_19829295_ChIP-Seq_ESCs_Human	0.75349529
61	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.74437962
62	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.74417074
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.73507739
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.73320366
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.72614982
66	AHR_22903824_ChIP-Seq_MCF-7_Human	0.72549196
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.72507108
68	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.72080921
69	EWS_26573619_Chip-Seq_HEK293_Human	0.72028546
70	HTT_18923047_ChIP-ChIP_STHdh_Human	0.71888546
71	SMRT_27268052_Chip-Seq_Bcells_Human	0.71339371
72	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.70501220
73	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.70314274
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.70272523
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.70200783
76	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.69474020
77	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.69258377
78	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.65263470
79	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.64855757
80	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.63066072
81	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.63063106
82	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.62504140
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.62425194
84	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.61849872
85	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.61346731
86	P300_19829295_ChIP-Seq_ESCs_Human	0.61264649
87	TP53_22573176_ChIP-Seq_HFKS_Human	0.61040118
88	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.60788539
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.60780103
90	DROSHA_22980978_ChIP-Seq_HELA_Human	0.60659575
91	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.60144244
92	TP53_16413492_ChIP-PET_HCT116_Human	0.59563752
93	REST_21632747_ChIP-Seq_MESCs_Mouse	0.59487351
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.59446786
95	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.58347342
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.57050654
97	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.56675883
98	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.55830296
99	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.54814158
100	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.54362808

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.99715379
2	MP0006292_abnormal_olfactory_placode	4.48486959
3	MP0008877_abnormal_DNA_methylation	4.42045337
4	MP0008789_abnormal_olfactory_epithelium	4.11235486
5	MP0005394_taste/olfaction_phenotype	3.69527523
6	MP0005499_abnormal_olfactory_system	3.69527523
7	MP0005395_other_phenotype	3.58687278
8	MP0002139_abnormal_hepatobiliary_system	3.16228066
9	MP0003890_abnormal_embryonic-extraembry	2.98703168
10	MP0008057_abnormal_DNA_replication	2.96450619
11	MP0003699_abnormal_female_reproductive	2.81223423
12	MP0003693_abnormal_embryo_hatching	2.67594823
13	MP0005360_urolithiasis	2.66215266
14	MP0002138_abnormal_hepatobiliary_system	2.65981025
15	MP0010234_abnormal_vibrissa_follicle	2.64168430
16	MP0010030_abnormal_orbit_morphology	2.47289103
17	MP0001929_abnormal_gametogenesis	2.40092642
18	MP0003879_abnormal_hair_cell	2.31539924
19	MP0002234_abnormal_pharynx_morphology	2.20393199
20	MP0002210_abnormal_sex_determination	2.12833053
21	MP0003077_abnormal_cell_cycle	2.01029782
22	MP0003950_abnormal_plasma_membrane	1.94539505
23	MP0003183_abnormal_peptide_metabolism	1.85592099
24	MP0008058_abnormal_DNA_repair	1.85573069
25	MP0010094_abnormal_chromosome_stability	1.81391109
26	MP0000653_abnormal_sex_gland	1.79813599
27	MP0000566_synostosis	1.78862052
28	MP0002161_abnormal_fertility/fecundity	1.77037651
29	MP0005410_abnormal_fertilization	1.67315421
30	MP0003111_abnormal_nucleus_morphology	1.61333570
31	MP0001119_abnormal_female_reproductive	1.61223631
32	MP0010307_abnormal_tumor_latency	1.55601172
33	MP0009840_abnormal_foam_cell	1.48051686
34	MP0001730_embryonic_growth_arrest	1.45711143
35	MP0003121_genomic_imprinting	1.43636073
36	MP0010368_abnormal_lymphatic_system	1.42115383
37	MP0002160_abnormal_reproductive_system	1.35949237
38	MP0008932_abnormal_embryonic_tissue	1.28042259
39	MP0001293_anophthalmia	1.26905659
40	MP0005646_abnormal_pituitary_gland	1.25898659
41	MP0001145_abnormal_male_reproductive	1.23816621
42	MP0005389_reproductive_system_phenotype	1.22809630
43	MP0000631_abnormal_neuroendocrine_gland	1.22273897
44	MP0003252_abnormal_bile_duct	1.22087408
45	MP0000762_abnormal_tongue_morphology	1.19824275
46	MP0005647_abnormal_sex_gland	1.17586900
47	MP0002233_abnormal_nose_morphology	1.09344534
48	MP0000427_abnormal_hair_cycle	1.08043910
49	MP0001984_abnormal_olfaction	1.07508677
50	MP0003698_abnormal_male_reproductive	1.05250893
51	MP0001672_abnormal_embryogenesis/_devel	1.04630742
52	MP0005380_embryogenesis_phenotype	1.04630742
53	MP0010678_abnormal_skin_adnexa	1.00087052
54	MP0001986_abnormal_taste_sensitivity	0.97512856
55	MP0004142_abnormal_muscle_tone	0.93580120
56	MP0003119_abnormal_digestive_system	0.89386159
57	MP0002272_abnormal_nervous_system	0.87701524
58	MP0000350_abnormal_cell_proliferation	0.87325861
59	MP0001664_abnormal_digestion	0.84177002
60	MP0005085_abnormal_gallbladder_physiolo	0.82287354
61	MP0001666_abnormal_nutrient_absorption	0.80055906
62	MP0006276_abnormal_autonomic_nervous	0.79454307
63	MP0003136_yellow_coat_color	0.72326072
64	MP0003868_abnormal_feces_composition	0.70570304
65	MP0001919_abnormal_reproductive_system	0.68326052
66	MP0001324_abnormal_eye_pigmentation	0.67201231
67	MP0000049_abnormal_middle_ear	0.66864186
68	MP0003941_abnormal_skin_development	0.65648435
69	MP0005551_abnormal_eye_electrophysiolog	0.64610896
70	MP0004957_abnormal_blastocyst_morpholog	0.63125732
71	MP0000678_abnormal_parathyroid_gland	0.62402403
72	MP0009379_abnormal_foot_pigmentation	0.62086499
73	MP0002796_impaired_skin_barrier	0.61392177
74	MP0002084_abnormal_developmental_patter	0.58892800
75	MP0001502_abnormal_circadian_rhythm	0.58462600
76	MP0002089_abnormal_postnatal_growth/wei	0.56250503
77	MP0005501_abnormal_skin_physiology	0.54057730
78	MP0003959_abnormal_lean_body	0.51669772
79	MP0001963_abnormal_hearing_physiology	0.51323330
80	MP0002127_abnormal_cardiovascular_syste	0.50432561
81	MP0005075_abnormal_melanosome_morpholog	0.49416724
82	MP0005076_abnormal_cell_differentiation	0.47687886
83	MP0000015_abnormal_ear_pigmentation	0.47548357
84	MP0002085_abnormal_embryonic_tissue	0.45533691
85	MP0000733_abnormal_muscle_development	0.45063101
86	MP0003935_abnormal_craniofacial_develop	0.44738377
87	MP0002928_abnormal_bile_duct	0.43400080
88	MP0003984_embryonic_growth_retardation	0.42961639
89	MP0001697_abnormal_embryo_size	0.41591586
90	MP0000383_abnormal_hair_follicle	0.40018992
91	MP0000377_abnormal_hair_follicle	0.39992091
92	MP0006138_congestive_heart_failure	0.39931647
93	MP0002735_abnormal_chemical_nociception	0.39314270
94	MP0002088_abnormal_embryonic_growth/wei	0.39280539
95	MP0005409_darkened_coat_color	0.39181284
96	MP0002090_abnormal_vision	0.37542325
97	MP0003755_abnormal_palate_morphology	0.37253320
98	MP0002873_normal_phenotype	0.36431882
99	MP0002169_no_abnormal_phenotype	0.35889276
100	MP0000428_abnormal_craniofacial_morphol	0.35371293

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.81229086
2	Supernumerary spleens (HP:0009799)	5.45781108
3	Hypoplasia of the fovea (HP:0007750)	5.39552142
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.39552142
5	Abnormality of abdominal situs (HP:0011620)	5.19859424
6	Abdominal situs inversus (HP:0003363)	5.19859424
7	Anterior segment dysgenesis (HP:0007700)	5.17675447
8	Impulsivity (HP:0100710)	4.86097565
9	Lip pit (HP:0100267)	4.85984906
10	Osteomalacia (HP:0002749)	4.85601411
11	Facial hemangioma (HP:0000329)	4.71765163
12	Cholecystitis (HP:0001082)	4.67763610
13	Abnormal gallbladder physiology (HP:0012438)	4.67763610
14	Abnormality of the fovea (HP:0000493)	4.55879301
15	Papillary thyroid carcinoma (HP:0002895)	4.52267289
16	Male infertility (HP:0003251)	4.27887718
17	Hypophosphatemic rickets (HP:0004912)	4.25485444
18	Septo-optic dysplasia (HP:0100842)	4.06364223
19	Infertility (HP:0000789)	4.05315131
20	Oligodactyly (hands) (HP:0001180)	3.91840978
21	Premature ovarian failure (HP:0008209)	3.84203183
22	Chromsome breakage (HP:0040012)	3.72474297
23	Azoospermia (HP:0000027)	3.71705183
24	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.61412426
25	Malnutrition (HP:0004395)	3.48792142
26	Apathy (HP:0000741)	3.44762325
27	Aplasia/Hypoplasia of the macula (HP:0008059)	3.44693695
28	Diminished motivation (HP:0000745)	3.33029275
29	Absent septum pellucidum (HP:0001331)	3.27925985
30	Gonadotropin excess (HP:0000837)	3.26649600
31	Median cleft lip (HP:0000161)	3.25805370
32	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.16009747
33	Hypokinesia (HP:0002375)	3.13859462
34	Abnormality of the labia minora (HP:0012880)	3.05045878
35	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.94198076
36	Capillary hemangiomas (HP:0005306)	2.89955705
37	Oligodactyly (HP:0012165)	2.87890302
38	Short tibia (HP:0005736)	2.87511879
39	Abnormal spermatogenesis (HP:0008669)	2.79102255
40	Urethral obstruction (HP:0000796)	2.78050482
41	Abnormality of the septum pellucidum (HP:0007375)	2.77895381
42	Hypergonadotropic hypogonadism (HP:0000815)	2.67875716
43	Aplasia of the musculature (HP:0100854)	2.66379138
44	Spinal cord compression (HP:0002176)	2.64553269
45	Enlarged penis (HP:0000040)	2.63268102
46	Wrist flexion contracture (HP:0001239)	2.62545144
47	Truncal obesity (HP:0001956)	2.61702077
48	Lower limb hyperreflexia (HP:0002395)	2.54803238
49	Loss of speech (HP:0002371)	2.52966850
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.51624634
51	Metaphyseal irregularity (HP:0003025)	2.51243618
52	Conjunctival telangiectasia (HP:0000524)	2.50621602
53	Thyroid carcinoma (HP:0002890)	2.50047020
54	Myokymia (HP:0002411)	2.49720252
55	Muscle stiffness (HP:0003552)	2.44110811
56	Skin pits (HP:0100276)	2.42451651
57	Fair hair (HP:0002286)	2.42064189
58	Intrahepatic cholestasis (HP:0001406)	2.27715843
59	Secondary amenorrhea (HP:0000869)	2.27375787
60	Anhidrosis (HP:0000970)	2.26929429
61	Striae distensae (HP:0001065)	2.23923919
62	Abnormality of the anterior chamber (HP:0000593)	2.21763793
63	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.21245637
64	Dysdiadochokinesis (HP:0002075)	2.19731062
65	Bundle branch block (HP:0011710)	2.18828602
66	Proximal tubulopathy (HP:0000114)	2.18312942
67	Maternal diabetes (HP:0009800)	2.17859108
68	Stillbirth (HP:0003826)	2.15009680
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.13820657
70	Congenital sensorineural hearing impairment (HP:0008527)	2.08708691
71	Abnormal biliary tract physiology (HP:0012439)	2.04234573
72	Bile duct proliferation (HP:0001408)	2.04234573
73	Abnormality of the phalanges of the hallux (HP:0010057)	2.03243133
74	Sensory axonal neuropathy (HP:0003390)	2.02293347
75	Posterior subcapsular cataract (HP:0007787)	2.01622552
76	Generalized aminoaciduria (HP:0002909)	2.00206765
77	Hydroureter (HP:0000072)	1.95714594
78	Nephroblastoma (Wilms tumor) (HP:0002667)	1.93973495
79	Ankle contracture (HP:0006466)	1.92654030
80	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.92359216
81	Abnormal lung lobation (HP:0002101)	1.92318130
82	Abnormal ciliary motility (HP:0012262)	1.91922227
83	Increased circulating renin level (HP:0000848)	1.91538163
84	Heterotopia (HP:0002282)	1.91076985
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88578059
86	Abnormality of chromosome stability (HP:0003220)	1.88220347
87	Subcapsular cataract (HP:0000523)	1.87051286
88	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.86205030
89	Hip contracture (HP:0003273)	1.82846045
90	Embryonal renal neoplasm (HP:0011794)	1.82271520
91	Limb hypertonia (HP:0002509)	1.80799660
92	Cone-rod dystrophy (HP:0000548)	1.79669018
93	Duodenal stenosis (HP:0100867)	1.74865184
94	Small intestinal stenosis (HP:0012848)	1.74865184
95	Pulmonary fibrosis (HP:0002206)	1.74364980
96	Meckel diverticulum (HP:0002245)	1.74224030
97	Abnormality of chromosome segregation (HP:0002916)	1.73817234
98	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.73750293
99	Hypohidrosis (HP:0000966)	1.73595052
100	Abnormality of the preputium (HP:0100587)	1.73290418

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.42405434
2	MAP3K13	5.88246725
3	ARAF	5.83921803
4	CDK12	3.34776161
5	NEK6	3.15364294
6	STK24	3.08365729
7	BRAF	2.95431927
8	TTK	2.93082322
9	TAOK3	2.88947747
10	MOS	2.56298468
11	CDK9	2.40833715
12	AURKA	2.35768089
13	MET	2.34327780
14	KSR2	1.98080705
15	CDC7	1.83365913
16	RAF1	1.82370281
17	NTRK2	1.80451263
18	PRKCI	1.56259921
19	TRIM28	1.56154378
20	MELK	1.49735756
21	EIF2AK3	1.44129389
22	CDK7	1.42980236
23	TNIK	1.27943088
24	PLK1	1.26125277
25	STK3	1.25925178
26	KSR1	1.25385682
27	BUB1	1.11591173
28	BRSK1	1.04395581
29	MAP3K8	0.97851333
30	PTK2	0.95026747
31	PIM1	0.94551034
32	CHEK1	0.91408353
33	WNK1	0.89746961
34	ZAK	0.89529840
35	NEK2	0.83323336
36	MST4	0.77691409
37	EEF2K	0.77451980
38	CDK19	0.76902035
39	MAPKAPK3	0.76799577
40	CDK8	0.76086267
41	CAMK1D	0.75015468
42	NUAK1	0.74596373
43	CDK2	0.74036237
44	CSNK1G1	0.73561909
45	TGFBR1	0.71176873
46	MARK3	0.70182199
47	NEK9	0.69679494
48	TNK2	0.69637107
49	TIE1	0.67136192
50	PLK3	0.65018841
51	AURKB	0.64474465
52	CHEK2	0.64065580
53	DMPK	0.63614204
54	MTOR	0.58682181
55	ATM	0.58676989
56	BMPR1B	0.58438435
57	CSNK1D	0.57002740
58	STK39	0.56653311
59	NTRK3	0.55688018
60	PAK1	0.53985615
61	CDK1	0.51207808
62	PRKG1	0.49147918
63	CSNK1G3	0.48585683
64	BRD4	0.48248170
65	PRKCZ	0.45947473
66	MAPK13	0.43084858
67	BRSK2	0.41999743
68	ATR	0.40429244
69	CAMK1G	0.40388568
70	PKN1	0.39408568
71	LRRK2	0.37110593
72	CSNK1E	0.36599640
73	MAP3K5	0.35569913
74	CDK5	0.35483830
75	CSNK1A1L	0.32314848
76	SRPK1	0.31082668
77	PDK1	0.30358543
78	VRK1	0.29483574
79	CAMK2A	0.29108411
80	GSK3B	0.27546177
81	TLK1	0.26539546
82	CHUK	0.25968194
83	TRPM7	0.25874842
84	MAPK1	0.25786988
85	CSNK1G2	0.25783991
86	PRKACB	0.25064835
87	PRKACA	0.23489050
88	MAPK10	0.22821644
89	ACVR1B	0.22255897
90	TYRO3	0.21499618
91	AKT2	0.21066928
92	MAP3K4	0.20711420
93	MAPK11	0.19411562
94	CLK1	0.16227012
95	PBK	0.15149829
96	TESK2	0.13385731
97	PDPK1	0.13380413
98	CAMK4	0.12942510
99	EGFR	0.11055257
100	CAMK1	0.11052226

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.27677577
2	Cell cycle_Homo sapiens_hsa04110	4.51714439
3	Ovarian steroidogenesis_Homo sapiens_hsa04913	4.14904160
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.58721824
5	Mismatch repair_Homo sapiens_hsa03430	3.49333177
6	Oocyte meiosis_Homo sapiens_hsa04114	3.41331326
7	Caffeine metabolism_Homo sapiens_hsa00232	2.83675762
8	Base excision repair_Homo sapiens_hsa03410	2.70835832
9	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.68721617
10	RNA degradation_Homo sapiens_hsa03018	2.67929030
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.65757619
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.48016973
13	DNA replication_Homo sapiens_hsa03030	2.21426739
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.15479967
15	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.11531458
16	Fanconi anemia pathway_Homo sapiens_hsa03460	2.10250416
17	Homologous recombination_Homo sapiens_hsa03440	1.97407904
18	Circadian rhythm_Homo sapiens_hsa04710	1.88090696
19	RNA transport_Homo sapiens_hsa03013	1.87934007
20	Olfactory transduction_Homo sapiens_hsa04740	1.81248883
21	Gap junction_Homo sapiens_hsa04540	1.77970742
22	p53 signaling pathway_Homo sapiens_hsa04115	1.77512465
23	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.66974820
24	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.66515990
25	Thyroid cancer_Homo sapiens_hsa05216	1.53044372
26	Folate biosynthesis_Homo sapiens_hsa00790	1.40974341
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36768395
28	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.28151310
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.20847722
30	Phototransduction_Homo sapiens_hsa04744	1.16614479
31	RNA polymerase_Homo sapiens_hsa03020	1.15634156
32	ABC transporters_Homo sapiens_hsa02010	1.07124074
33	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.02667024
34	mTOR signaling pathway_Homo sapiens_hsa04150	0.91564299
35	Nicotine addiction_Homo sapiens_hsa05033	0.90691610
36	Bile secretion_Homo sapiens_hsa04976	0.84924105
37	GABAergic synapse_Homo sapiens_hsa04727	0.84905871
38	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.82743236
39	Morphine addiction_Homo sapiens_hsa05032	0.81274233
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.76415227
41	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.71673557
42	FoxO signaling pathway_Homo sapiens_hsa04068	0.68637130
43	Taste transduction_Homo sapiens_hsa04742	0.68603225
44	Adherens junction_Homo sapiens_hsa04520	0.64752641
45	Fatty acid elongation_Homo sapiens_hsa00062	0.64476311
46	MicroRNAs in cancer_Homo sapiens_hsa05206	0.64157736
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.62927976
48	Long-term depression_Homo sapiens_hsa04730	0.58606236
49	Viral carcinogenesis_Homo sapiens_hsa05203	0.51551288
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49954257
51	Herpes simplex infection_Homo sapiens_hsa05168	0.48662736
52	Purine metabolism_Homo sapiens_hsa00230	0.48462907
53	Serotonergic synapse_Homo sapiens_hsa04726	0.47984951
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47683619
55	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45907557
56	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41842572
57	Notch signaling pathway_Homo sapiens_hsa04330	0.40727592
58	Small cell lung cancer_Homo sapiens_hsa05222	0.37990092
59	Lysine degradation_Homo sapiens_hsa00310	0.37933529
60	Wnt signaling pathway_Homo sapiens_hsa04310	0.37430764
61	ErbB signaling pathway_Homo sapiens_hsa04012	0.37139273
62	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.36469599
63	Arginine biosynthesis_Homo sapiens_hsa00220	0.34337535
64	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.33599965
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.33112890
66	HTLV-I infection_Homo sapiens_hsa05166	0.32053369
67	Ras signaling pathway_Homo sapiens_hsa04014	0.30914383
68	Regulation of autophagy_Homo sapiens_hsa04140	0.28149578
69	Endometrial cancer_Homo sapiens_hsa05213	0.27644621
70	Phagosome_Homo sapiens_hsa04145	0.26743810
71	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.24360863
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22805429
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.22433542
74	Renal cell carcinoma_Homo sapiens_hsa05211	0.21765490
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.21148769
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.20819048
77	Protein digestion and absorption_Homo sapiens_hsa04974	0.20252716
78	Huntingtons disease_Homo sapiens_hsa05016	0.19467887
79	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.19261832
80	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.17610724
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.16579617
82	Cholinergic synapse_Homo sapiens_hsa04725	0.16416775
83	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.16330920
84	Long-term potentiation_Homo sapiens_hsa04720	0.15791691
85	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.15432873
86	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.14428811
87	Prostate cancer_Homo sapiens_hsa05215	0.12777797
88	Non-small cell lung cancer_Homo sapiens_hsa05223	0.10748887
89	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.10602371
90	Circadian entrainment_Homo sapiens_hsa04713	0.10588110
91	Hepatitis B_Homo sapiens_hsa05161	0.10580765
92	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.09013184
93	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.08551924
94	Melanogenesis_Homo sapiens_hsa04916	0.08531431
95	Amoebiasis_Homo sapiens_hsa05146	0.08382968
96	Spliceosome_Homo sapiens_hsa03040	0.07959679
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.07565840
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.07297784
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.06690820
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.06685499

TUBB8P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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