ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	9.18936064
2	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	8.97528165
3	regulation of DNA methylation (GO:0044030)	8.35150418
4	oocyte development (GO:0048599)	7.92907496
5	regulation of retinoic acid receptor signaling pathway (GO:0048385)	7.66270636
6	piRNA metabolic process (GO:0034587)	7.05852108
7	negative regulation of reproductive process (GO:2000242)	6.94480175
8	protein kinase C signaling (GO:0070528)	6.81380086
9	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.64425072
10	regulation of meiosis I (GO:0060631)	6.63548822
11	meiotic cell cycle (GO:0051321)	6.58119873
12	positive regulation of humoral immune response (GO:0002922)	6.49209663
13	retinal cone cell development (GO:0046549)	6.36207739
14	regulation of histone H3-K9 methylation (GO:0051570)	6.18856622
15	reproduction (GO:0000003)	6.17005600
16	DNA methylation involved in gamete generation (GO:0043046)	6.11092011
17	positive regulation of histone H3-K4 methylation (GO:0051571)	5.83197845
18	binding of sperm to zona pellucida (GO:0007339)	5.63538086
19	neuron fate determination (GO:0048664)	5.49187615
20	female gamete generation (GO:0007292)	5.33305914
21	citrulline biosynthetic process (GO:0019240)	5.30795994
22	negative regulation of histone methylation (GO:0031061)	5.30631609
23	mitotic chromosome condensation (GO:0007076)	4.86315629
24	regulation of steroid hormone secretion (GO:2000831)	4.79081380
25	regulation of cell maturation (GO:1903429)	4.70305549
26	sperm-egg recognition (GO:0035036)	4.53584138
27	protein localization to kinetochore (GO:0034501)	4.51130918
28	single fertilization (GO:0007338)	4.45477236
29	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.35882426
30	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.35882426
31	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.35882426
32	fertilization (GO:0009566)	4.34819556
33	protein localization to chromosome, centromeric region (GO:0071459)	4.29907780
34	regulation of chromatin binding (GO:0035561)	4.22800028
35	regulation of hypersensitivity (GO:0002883)	4.18989385
36	positive regulation of reproductive process (GO:2000243)	4.18386195
37	positive regulation of chromosome segregation (GO:0051984)	4.12621993
38	regulation of calcium ion-dependent exocytosis (GO:0017158)	4.06949625
39	mitotic metaphase plate congression (GO:0007080)	4.06413243
40	sequestering of actin monomers (GO:0042989)	3.93308701
41	gene silencing by RNA (GO:0031047)	3.82926812
42	establishment of chromosome localization (GO:0051303)	3.80971413
43	regulation of phospholipid biosynthetic process (GO:0071071)	3.80054328
44	male meiosis (GO:0007140)	3.78151714
45	glycine transport (GO:0015816)	3.73675442
46	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.71414242
47	regulation of reproductive process (GO:2000241)	3.70834942
48	positive regulation of gastrulation (GO:2000543)	3.69673244
49	meiosis I (GO:0007127)	3.69444955
50	DNA replication checkpoint (GO:0000076)	3.66816489
51	regulation of histone H3-K4 methylation (GO:0051569)	3.65830944
52	DNA methylation (GO:0006306)	3.63299071
53	DNA alkylation (GO:0006305)	3.63299071
54	regulation of spindle organization (GO:0090224)	3.54473473
55	cell-cell recognition (GO:0009988)	3.53662648
56	positive regulation of histone methylation (GO:0031062)	3.47630421
57	protein localization to chromosome (GO:0034502)	3.41872767
58	synaptonemal complex assembly (GO:0007130)	3.39699299
59	male meiosis I (GO:0007141)	3.38843261
60	regulation of meiosis (GO:0040020)	3.34578195
61	CENP-A containing nucleosome assembly (GO:0034080)	3.33663304
62	regulation of steroid hormone biosynthetic process (GO:0090030)	3.28694134
63	metaphase plate congression (GO:0051310)	3.28200127
64	synapsis (GO:0007129)	3.27090774
65	DNA replication-dependent nucleosome organization (GO:0034723)	3.25479069
66	DNA replication-dependent nucleosome assembly (GO:0006335)	3.25479069
67	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.24848145
68	citrulline metabolic process (GO:0000052)	3.23942215
69	attachment of spindle microtubules to kinetochore (GO:0008608)	3.18822057
70	positive regulation of endothelial cell differentiation (GO:0045603)	3.17920603
71	meiotic nuclear division (GO:0007126)	3.12147047
72	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.08364642
73	regulation of histone methylation (GO:0031060)	3.08272744
74	synaptonemal complex organization (GO:0070193)	3.05407015
75	chromosome organization involved in meiosis (GO:0070192)	3.04736534
76	regulation of spindle checkpoint (GO:0090231)	3.04134090
77	meiotic cell cycle process (GO:1903046)	2.99811433
78	positive regulation of hormone biosynthetic process (GO:0046886)	2.97580834
79	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.97481470
80	primitive streak formation (GO:0090009)	2.96945306
81	regulation of chromatin silencing (GO:0031935)	2.96935766
82	chromatin remodeling at centromere (GO:0031055)	2.96678329
83	negative regulation of histone modification (GO:0031057)	2.96017240
84	proteasome assembly (GO:0043248)	2.91575239
85	type B pancreatic cell development (GO:0003323)	2.90851596
86	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.90845257
87	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.88878383
88	N-terminal protein amino acid acetylation (GO:0006474)	2.87089407
89	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.84297044
90	centriole replication (GO:0007099)	2.83493234
91	protein K6-linked ubiquitination (GO:0085020)	2.82632597
92	relaxation of smooth muscle (GO:0044557)	2.81457914
93	peptidyl-arginine modification (GO:0018195)	2.80991444
94	regulation of meiotic cell cycle (GO:0051445)	2.79892489
95	behavioral response to nicotine (GO:0035095)	2.79786263
96	negative regulation of circadian rhythm (GO:0042754)	2.79094570
97	cellular response to pH (GO:0071467)	2.75837431
98	DNA methylation or demethylation (GO:0044728)	2.75713475
99	regulation of acrosome reaction (GO:0060046)	11.4070987
100	regulation of female gonad development (GO:2000194)	10.6243245

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.59427167
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.47718174
3	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.17759463
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.17759463
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.17759463
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.14847783
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.94463745
8	E2F7_22180533_ChIP-Seq_HELA_Human	2.93006162
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.83492450
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.74317654
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.72298011
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.45923403
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40242620
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.23976756
15	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.23717947
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15868294
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.15688946
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.15246120
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.06750940
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.05553179
21	EZH2_22144423_ChIP-Seq_EOC_Human	15.1789688
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.71591254
23	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.67829447
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.66070284
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.62397521
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53971881
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.53658586
28	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.45871723
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.37151118
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37025494
31	AR_21909140_ChIP-Seq_LNCAP_Human	1.34463236
32	ZNF274_21170338_ChIP-Seq_K562_Hela	1.29583057
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.29223540
34	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.27863147
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.27269857
36	VDR_22108803_ChIP-Seq_LS180_Human	1.19081354
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17292177
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.16151038
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.12001908
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.11825051
41	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.10058649
42	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.09684747
43	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.09468656
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09425853
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08832085
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07255985
47	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.03116231
48	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.02782324
49	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.00244954
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.99705244
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99159379
52	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.90547783
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.90362074
54	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89991224
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89530826
56	MYC_18940864_ChIP-ChIP_HL60_Human	0.88737019
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.88632060
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.88432592
59	CBP_21632823_ChIP-Seq_H3396_Human	0.88332821
60	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.86741377
61	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.85300632
62	VDR_23849224_ChIP-Seq_CD4+_Human	0.84570725
63	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.82452775
64	ELK1_19687146_ChIP-ChIP_HELA_Human	0.80782286
65	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.76009544
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.74760545
67	TP53_22573176_ChIP-Seq_HFKS_Human	0.74675891
68	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.72403291
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.72188003
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.70904418
71	AR_25329375_ChIP-Seq_VCAP_Human	0.70714596
72	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.70532927
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.69416179
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.66913048
75	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.66913048
76	CBP_20019798_ChIP-Seq_JUKART_Human	0.66511670
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.66511670
78	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.66365925
79	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.65920974
80	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.65109057
81	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.64077869
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.63209071
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.62997133
84	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.62314525
85	RUNX2_22187159_ChIP-Seq_PCA_Human	0.61799485
86	NCOR_22424771_ChIP-Seq_293T_Human	0.61055707
87	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.60807342
88	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.60780895
89	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.60063029
90	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.59544111
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.58817952
92	AR_20517297_ChIP-Seq_VCAP_Human	0.58716993
93	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.58685188
94	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.58230125
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.57802865
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.57039051
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.56986834
98	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.56807544
99	SMAD4_21799915_ChIP-Seq_A2780_Human	0.56640065
100	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.56104381

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.27262180
2	MP0008789_abnormal_olfactory_epithelium	4.39454021
3	MP0008877_abnormal_DNA_methylation	4.20931386
4	MP0005394_taste/olfaction_phenotype	4.20684306
5	MP0005499_abnormal_olfactory_system	4.20684306
6	MP0006292_abnormal_olfactory_placode	4.19695943
7	MP0005395_other_phenotype	3.08177941
8	MP0002638_abnormal_pupillary_reflex	2.70769564
9	MP0010030_abnormal_orbit_morphology	2.70435565
10	MP0002138_abnormal_hepatobiliary_system	2.68186958
11	MP0003699_abnormal_female_reproductive	2.64753075
12	MP0003693_abnormal_embryo_hatching	2.64437793
13	MP0002139_abnormal_hepatobiliary_system	2.64105754
14	MP0001929_abnormal_gametogenesis	2.46075475
15	MP0002210_abnormal_sex_determination	2.20490243
16	MP0003077_abnormal_cell_cycle	2.14740956
17	MP0003111_abnormal_nucleus_morphology	2.08157386
18	MP0005360_urolithiasis	2.05310534
19	MP0003890_abnormal_embryonic-extraembry	1.96477518
20	MP0005410_abnormal_fertilization	1.94827571
21	MP0003121_genomic_imprinting	1.92599766
22	MP0000653_abnormal_sex_gland	1.90406134
23	MP0008057_abnormal_DNA_replication	1.89142199
24	MP0008058_abnormal_DNA_repair	1.88316315
25	MP0002234_abnormal_pharynx_morphology	1.80891903
26	MP0002161_abnormal_fertility/fecundity	1.78108670
27	MP0003950_abnormal_plasma_membrane	1.76981935
28	MP0010094_abnormal_chromosome_stability	1.76512662
29	MP0008932_abnormal_embryonic_tissue	1.69685597
30	MP0001119_abnormal_female_reproductive	1.64255936
31	MP0003879_abnormal_hair_cell	1.56673414
32	MP0002160_abnormal_reproductive_system	1.56565080
33	MP0001730_embryonic_growth_arrest	1.53832251
34	MP0006276_abnormal_autonomic_nervous	1.49361870
35	MP0005389_reproductive_system_phenotype	1.44013250
36	MP0001984_abnormal_olfaction	1.39013819
37	MP0009840_abnormal_foam_cell	1.33116919
38	MP0001293_anophthalmia	1.32038955
39	MP0001986_abnormal_taste_sensitivity	1.29831049
40	MP0001145_abnormal_male_reproductive	1.27893441
41	MP0004957_abnormal_blastocyst_morpholog	1.24550323
42	MP0005085_abnormal_gallbladder_physiolo	1.17976921
43	MP0010368_abnormal_lymphatic_system	1.15685669
44	MP0002233_abnormal_nose_morphology	1.15181164
45	MP0003252_abnormal_bile_duct	1.15084713
46	MP0000566_synostosis	1.11921566
47	MP0003698_abnormal_male_reproductive	1.06353124
48	MP0004142_abnormal_muscle_tone	1.03625413
49	MP0010307_abnormal_tumor_latency	1.01109616
50	MP0001672_abnormal_embryogenesis/_devel	0.99873610
51	MP0005380_embryogenesis_phenotype	0.99873610
52	MP0010386_abnormal_urinary_bladder	0.98731706
53	MP0001664_abnormal_digestion	0.94617448
54	MP0010234_abnormal_vibrissa_follicle	0.92722057
55	MP0003136_yellow_coat_color	0.90517851
56	MP0000350_abnormal_cell_proliferation	0.90429096
57	MP0002272_abnormal_nervous_system	0.88395857
58	MP0000762_abnormal_tongue_morphology	0.87073072
59	MP0003183_abnormal_peptide_metabolism	0.86681605
60	MP0000631_abnormal_neuroendocrine_gland	0.86026902
61	MP0001919_abnormal_reproductive_system	0.85852830
62	MP0003941_abnormal_skin_development	0.84725926
63	MP0003119_abnormal_digestive_system	0.83665633
64	MP0005647_abnormal_sex_gland	0.81637510
65	MP0001502_abnormal_circadian_rhythm	0.80378176
66	MP0005645_abnormal_hypothalamus_physiol	0.74827416
67	MP0002089_abnormal_postnatal_growth/wei	0.73917057
68	MP0005646_abnormal_pituitary_gland	0.71219611
69	MP0005551_abnormal_eye_electrophysiolog	0.70248304
70	MP0001666_abnormal_nutrient_absorption	0.66127427
71	MP0001905_abnormal_dopamine_level	0.62234790
72	MP0002102_abnormal_ear_morphology	0.59865131
73	MP0002653_abnormal_ependyma_morphology	0.58806935
74	MP0002090_abnormal_vision	0.58748991
75	MP0000427_abnormal_hair_cycle	0.57918191
76	MP0005501_abnormal_skin_physiology	0.56916732
77	MP0003123_paternal_imprinting	0.54369697
78	MP0002127_abnormal_cardiovascular_syste	0.54060032
79	MP0002084_abnormal_developmental_patter	0.53639820
80	MP0000049_abnormal_middle_ear	0.50805572
81	MP0005197_abnormal_uvea_morphology	0.50685803
82	MP0003959_abnormal_lean_body	0.50205553
83	MP0002085_abnormal_embryonic_tissue	0.49009210
84	MP0002796_impaired_skin_barrier	0.48475413
85	MP0001529_abnormal_vocalization	0.48310956
86	MP0001697_abnormal_embryo_size	0.47604393
87	MP0005464_abnormal_platelet_physiology	0.47421455
88	MP0002873_normal_phenotype	0.45444388
89	MP0002169_no_abnormal_phenotype	0.45279827
90	MP0005319_abnormal_enzyme/_coenzyme	0.44464755
91	MP0002751_abnormal_autonomic_nervous	0.44119391
92	MP0003984_embryonic_growth_retardation	0.43224423
93	MP0003786_premature_aging	0.43161387
94	MP0002177_abnormal_outer_ear	0.42896839
95	MP0005083_abnormal_biliary_tract	0.42320773
96	MP0000313_abnormal_cell_death	0.42110066
97	MP0002088_abnormal_embryonic_growth/wei	0.40801056
98	MP0001324_abnormal_eye_pigmentation	0.40781001
99	MP0002080_prenatal_lethality	0.39929188
100	MP0002734_abnormal_mechanical_nocicepti	0.39883234

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	6.10525989
2	Hypoplasia of the fovea (HP:0007750)	5.42935780
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.42935780
4	Cholecystitis (HP:0001082)	5.03157660
5	Abnormal gallbladder physiology (HP:0012438)	5.03157660
6	Supernumerary spleens (HP:0009799)	4.81459673
7	Anterior segment dysgenesis (HP:0007700)	4.74461245
8	Abnormality of the fovea (HP:0000493)	4.68151769
9	Abnormality of abdominal situs (HP:0011620)	4.56971731
10	Abdominal situs inversus (HP:0003363)	4.56971731
11	Impulsivity (HP:0100710)	4.09788024
12	Male infertility (HP:0003251)	4.06562195
13	Infertility (HP:0000789)	3.84366499
14	Hypophosphatemic rickets (HP:0004912)	3.69109242
15	Septo-optic dysplasia (HP:0100842)	3.53478092
16	Lip pit (HP:0100267)	3.53098612
17	Apathy (HP:0000741)	3.46904392
18	Papillary thyroid carcinoma (HP:0002895)	3.44393053
19	Azoospermia (HP:0000027)	3.41926482
20	Hypokinesia (HP:0002375)	3.39443644
21	Abnormal spermatogenesis (HP:0008669)	3.32604553
22	Oligodactyly (hands) (HP:0001180)	3.29268677
23	Osteomalacia (HP:0002749)	3.28753351
24	Aplasia/Hypoplasia of the macula (HP:0008059)	3.27799628
25	Diminished motivation (HP:0000745)	3.22467791
26	Abnormality of the labia minora (HP:0012880)	3.22044758
27	Premature ovarian failure (HP:0008209)	3.19552333
28	Facial hemangioma (HP:0000329)	3.15537818
29	Hypergonadotropic hypogonadism (HP:0000815)	3.05295748
30	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.01483392
31	Absent septum pellucidum (HP:0001331)	2.96621889
32	Secondary amenorrhea (HP:0000869)	2.91737133
33	Short tibia (HP:0005736)	2.90762800
34	Generalized aminoaciduria (HP:0002909)	2.86465021
35	Median cleft lip (HP:0000161)	2.84472209
36	Myokymia (HP:0002411)	2.74051315
37	Gonadotropin excess (HP:0000837)	2.73898642
38	Malnutrition (HP:0004395)	2.72531529
39	Proximal tubulopathy (HP:0000114)	2.64137906
40	Abnormality of the septum pellucidum (HP:0007375)	2.52207677
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.49528340
42	Oligodactyly (HP:0012165)	2.48096073
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.45679216
44	Intrahepatic cholestasis (HP:0001406)	2.42252719
45	Pulmonary fibrosis (HP:0002206)	2.39730528
46	Fair hair (HP:0002286)	2.34187948
47	Aplasia of the musculature (HP:0100854)	2.31958796
48	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.31727986
49	Renal Fanconi syndrome (HP:0001994)	2.21246753
50	Chromsome breakage (HP:0040012)	2.20155329
51	Muscle stiffness (HP:0003552)	2.15861499
52	Abnormality of the anterior horn cell (HP:0006802)	2.15280574
53	Degeneration of anterior horn cells (HP:0002398)	2.15280574
54	Abnormal biliary tract physiology (HP:0012439)	2.12147859
55	Bile duct proliferation (HP:0001408)	2.12147859
56	Abnormal ciliary motility (HP:0012262)	2.11098481
57	Wrist flexion contracture (HP:0001239)	2.10328755
58	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.07081451
59	Thyroid-stimulating hormone excess (HP:0002925)	2.06494532
60	Tubulointerstitial nephritis (HP:0001970)	2.04027270
61	Thyroid carcinoma (HP:0002890)	1.99367810
62	Sensory axonal neuropathy (HP:0003390)	1.96337480
63	Sparse eyelashes (HP:0000653)	1.95984280
64	Capillary hemangiomas (HP:0005306)	1.93749781
65	Nausea (HP:0002018)	1.92031384
66	Abnormal auditory evoked potentials (HP:0006958)	1.91392286
67	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.91303361
68	Cleft eyelid (HP:0000625)	1.89917041
69	Abnormality of the anterior chamber (HP:0000593)	1.89192439
70	Hydroureter (HP:0000072)	1.87279818
71	Spinal muscular atrophy (HP:0007269)	1.86436664
72	Maternal diabetes (HP:0009800)	1.84439446
73	Pendular nystagmus (HP:0012043)	1.83750811
74	Conjunctival telangiectasia (HP:0000524)	1.83233719
75	Bundle branch block (HP:0011710)	1.78943121
76	Limb hypertonia (HP:0002509)	1.77569493
77	Posterior embryotoxon (HP:0000627)	1.75600432
78	Urethral obstruction (HP:0000796)	1.74916877
79	Striae distensae (HP:0001065)	1.73553823
80	Spinal cord compression (HP:0002176)	1.73493401
81	Stillbirth (HP:0003826)	1.71780588
82	Enlarged penis (HP:0000040)	1.69425258
83	Poor speech (HP:0002465)	1.69078238
84	Abnormality of the line of Schwalbe (HP:0008048)	1.68854363
85	Meckel diverticulum (HP:0002245)	1.68643463
86	Abnormality of the labia (HP:0000058)	1.67148429
87	Megaloblastic anemia (HP:0001889)	1.66043781
88	Lower limb hyperreflexia (HP:0002395)	1.65382619
89	Truncal obesity (HP:0001956)	1.65307269
90	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.65217321
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.62776393
92	Abnormality of midbrain morphology (HP:0002418)	1.62761212
93	Molar tooth sign on MRI (HP:0002419)	1.62761212
94	Decreased circulating renin level (HP:0003351)	1.61447896
95	Metaphyseal irregularity (HP:0003025)	1.61155646
96	Rhinitis (HP:0012384)	1.59791476
97	Abnormality of the preputium (HP:0100587)	1.59421334
98	Congenital sensorineural hearing impairment (HP:0008527)	1.58119003
99	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.57421148
100	Skin pits (HP:0100276)	1.56992682

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	4.98131757
2	MAP3K9	3.14909286
3	BUB1	3.07333358
4	TLK1	2.98090386
5	TRIM28	2.76380754
6	TESK2	2.73632839
7	TTK	2.68396477
8	MAP3K13	2.67014498
9	AURKA	2.66685907
10	CDK9	2.43008582
11	BRAF	2.42871538
12	NEK6	2.42422788
13	STK24	2.23570293
14	NUAK1	2.07892417
15	CDK12	2.02579687
16	MST4	2.00613571
17	BRSK1	1.99554075
18	PRKCI	1.98016198
19	MET	1.92386322
20	VRK2	1.91585476
21	TAOK3	1.90577143
22	ZAK	1.90433851
23	NTRK2	1.82395975
24	MAPKAPK3	1.80124416
25	RAF1	1.63451935
26	CDC7	1.58950321
27	EIF2AK3	1.57349420
28	TNIK	1.52713028
29	CDK7	1.51079400
30	MOS	1.45470893
31	PLK1	1.41566787
32	CSNK1G1	1.41266132
33	TESK1	1.39372786
34	PLK3	1.38670957
35	VRK1	1.37497586
36	CSNK1G3	1.35542423
37	PBK	1.35492620
38	CAMK1D	1.24817396
39	STK3	1.02761975
40	CDK8	1.02702661
41	AURKB	0.98131595
42	CSNK1A1L	0.96145727
43	FLT3	0.95017216
44	CSNK1G2	0.94917506
45	SRPK1	0.93854166
46	TAOK2	0.93243531
47	MELK	0.92561271
48	PAK1	0.87946392
49	CHEK1	0.82010842
50	PKN2	0.81655158
51	MAP2K7	0.80185802
52	CAMK1G	0.76645333
53	MAP3K8	0.73020100
54	NME1	0.71179381
55	DAPK1	0.70706613
56	CHEK2	0.70303451
57	MAPK13	0.68824486
58	LMTK2	0.66753416
59	CSNK1D	0.64454645
60	PTK2	0.62371114
61	BRSK2	0.61175507
62	PRKG1	0.61031816
63	CDK2	0.60643410
64	ATR	0.60603992
65	STK16	0.60150239
66	CDK19	0.59881210
67	EIF2AK2	0.54550619
68	KSR2	0.52994676
69	PIM1	0.52875212
70	LIMK1	0.52440277
71	NEK2	0.52355175
72	BCKDK	0.51683369
73	NTRK3	0.50857807
74	STK10	0.50215151
75	ATM	0.50184123
76	STK4	0.48562688
77	MARK3	0.46019593
78	PIM2	0.45021748
79	LRRK2	0.43870931
80	TIE1	0.43598257
81	CDK1	0.42242015
82	TSSK6	0.41719738
83	RIPK1	0.40554446
84	AKT2	0.39150185
85	CSNK1E	0.37971407
86	PKN1	0.37852344
87	BMPR1B	0.36607097
88	PRKCZ	0.36234486
89	MAP3K4	0.34976759
90	CDK5	0.33564944
91	CAMK2A	0.33496338
92	BRD4	0.32842750
93	NME2	0.32060706
94	DYRK3	0.31607319
95	STK39	0.29385726
96	KSR1	0.27819081
97	PLK2	0.27712854
98	PRKACA	0.26104699
99	CDK14	0.24785689
100	GRK5	0.24103694

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.78734436
2	Cell cycle_Homo sapiens_hsa04110	3.94056612
3	Mismatch repair_Homo sapiens_hsa03430	3.52696563
4	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.33022734
5	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.28217539
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.13291364
7	Oocyte meiosis_Homo sapiens_hsa04114	3.04258183
8	DNA replication_Homo sapiens_hsa03030	2.70639054
9	Proteasome_Homo sapiens_hsa03050	2.52779663
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.44235244
11	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.32787753
12	RNA degradation_Homo sapiens_hsa03018	2.28542298
13	Base excision repair_Homo sapiens_hsa03410	2.24691403
14	RNA polymerase_Homo sapiens_hsa03020	2.17330758
15	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.12609790
16	RNA transport_Homo sapiens_hsa03013	2.01134517
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98936669
18	Folate biosynthesis_Homo sapiens_hsa00790	1.97725534
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.96009063
20	Homologous recombination_Homo sapiens_hsa03440	1.88367202
21	Caffeine metabolism_Homo sapiens_hsa00232	1.81932717
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68715570
23	p53 signaling pathway_Homo sapiens_hsa04115	1.67035308
24	Gap junction_Homo sapiens_hsa04540	1.63418271
25	Huntingtons disease_Homo sapiens_hsa05016	1.61645643
26	Fatty acid elongation_Homo sapiens_hsa00062	1.56814145
27	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.50525504
28	Olfactory transduction_Homo sapiens_hsa04740	1.41514769
29	Circadian rhythm_Homo sapiens_hsa04710	1.37918209
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.36959964
31	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.35999591
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35104633
33	Parkinsons disease_Homo sapiens_hsa05012	1.33444060
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.32160697
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.22352520
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.08553544
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07862352
38	Purine metabolism_Homo sapiens_hsa00230	1.01777735
39	Regulation of autophagy_Homo sapiens_hsa04140	1.00166176
40	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.93035724
41	Thyroid cancer_Homo sapiens_hsa05216	0.88416977
42	Spliceosome_Homo sapiens_hsa03040	0.84306248
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.79713445
44	Nicotine addiction_Homo sapiens_hsa05033	0.78047447
45	Phototransduction_Homo sapiens_hsa04744	0.74190903
46	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.71941169
47	GABAergic synapse_Homo sapiens_hsa04727	0.67007637
48	Alzheimers disease_Homo sapiens_hsa05010	0.62773425
49	Alcoholism_Homo sapiens_hsa05034	0.61851010
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58497789
51	Phagosome_Homo sapiens_hsa04145	0.58211486
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57397194
53	Vibrio cholerae infection_Homo sapiens_hsa05110	0.54412154
54	Glutathione metabolism_Homo sapiens_hsa00480	0.52881531
55	Taste transduction_Homo sapiens_hsa04742	0.52784998
56	Morphine addiction_Homo sapiens_hsa05032	0.52193541
57	Viral carcinogenesis_Homo sapiens_hsa05203	0.51185276
58	ABC transporters_Homo sapiens_hsa02010	0.47549065
59	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43633861
60	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.42797705
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39584294
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39192176
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.38459670
64	Serotonergic synapse_Homo sapiens_hsa04726	0.36575520
65	Metabolic pathways_Homo sapiens_hsa01100	0.36018018
66	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35993093
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35587340
68	Adherens junction_Homo sapiens_hsa04520	0.31225945
69	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.30940193
70	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.29588228
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.28740802
72	Bile secretion_Homo sapiens_hsa04976	0.27222812
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.27143283
74	Protein export_Homo sapiens_hsa03060	0.26011928
75	Herpes simplex infection_Homo sapiens_hsa05168	0.23810554
76	Propanoate metabolism_Homo sapiens_hsa00640	0.23510295
77	Peroxisome_Homo sapiens_hsa04146	0.23279436
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.22361528
79	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.22249872
80	Wnt signaling pathway_Homo sapiens_hsa04310	0.22173991
81	Arginine biosynthesis_Homo sapiens_hsa00220	0.19255907
82	Tight junction_Homo sapiens_hsa04530	0.19247742
83	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.18660565
84	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.18542797
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.18488746
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.18350765
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.18067675
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.18013463
89	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.17818585
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.17813648
91	Ribosome_Homo sapiens_hsa03010	0.17582557
92	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.17578463
93	Carbon metabolism_Homo sapiens_hsa01200	0.15706775
94	MicroRNAs in cancer_Homo sapiens_hsa05206	0.14646887
95	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.14260220
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.14168867
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.13429410
98	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.12106570
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.11251020
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.09845318

TUBB8P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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