ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acrosome reaction (GO:0060046)	9.69093396
2	piRNA metabolic process (GO:0034587)	8.37315225
3	meiotic cell cycle (GO:0051321)	7.88669148
4	multicellular organism reproduction (GO:0032504)	7.87574048
5	oocyte development (GO:0048599)	7.50931804
6	regulation of meiosis I (GO:0060631)	7.38117500
7	retinal cone cell development (GO:0046549)	7.24489518
8	DNA methylation involved in gamete generation (GO:0043046)	6.96547247
9	protein kinase C signaling (GO:0070528)	6.70734679
10	positive regulation of histone H3-K4 methylation (GO:0051571)	6.66982080
11	regulation of histone H3-K9 methylation (GO:0051570)	6.49359155
12	negative regulation of reproductive process (GO:2000242)	6.44014187
13	female gamete generation (GO:0007292)	6.22890677
14	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.13866709
15	positive regulation of humoral immune response (GO:0002922)	5.93776018
16	glycine transport (GO:0015816)	5.83809549
17	regulation of steroid hormone secretion (GO:2000831)	5.64513562
18	negative regulation of histone methylation (GO:0031061)	5.36050881
19	regulation of cell maturation (GO:1903429)	5.20835057
20	reproduction (GO:0000003)	5.20604239
21	positive regulation of gastrulation (GO:2000543)	5.02718653
22	gene silencing by RNA (GO:0031047)	4.87735192
23	citrulline biosynthetic process (GO:0019240)	4.46229560
24	binding of sperm to zona pellucida (GO:0007339)	4.45160438
25	mitotic chromosome condensation (GO:0007076)	4.33883427
26	mitotic metaphase plate congression (GO:0007080)	4.27153803
27	positive regulation of reproductive process (GO:2000243)	4.17144901
28	centriole replication (GO:0007099)	4.17074293
29	DNA alkylation (GO:0006305)	4.14974993
30	DNA methylation (GO:0006306)	4.14974993
31	positive regulation of histone methylation (GO:0031062)	4.11228400
32	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.09028473
33	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.09028473
34	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.09028473
35	fertilization (GO:0009566)	4.08967030
36	regulation of meiosis (GO:0040020)	4.07014037
37	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.04380267
38	regulation of steroid hormone biosynthetic process (GO:0090030)	3.96660760
39	primitive streak formation (GO:0090009)	3.92312550
40	protein localization to kinetochore (GO:0034501)	3.89456211
41	protein localization to chromosome, centromeric region (GO:0071459)	3.88922214
42	single fertilization (GO:0007338)	3.88241229
43	establishment of chromosome localization (GO:0051303)	3.84980177
44	neuron fate determination (GO:0048664)	3.82572680
45	phosphorelay signal transduction system (GO:0000160)	3.79363791
46	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.78713894
47	oogenesis (GO:0048477)	3.78682974
48	regulation of reproductive process (GO:2000241)	3.78576451
49	regulation of histone H3-K4 methylation (GO:0051569)	3.78360076
50	synapsis (GO:0007129)	3.74226289
51	negative regulation of hormone biosynthetic process (GO:0032353)	3.70336747
52	attachment of spindle microtubules to kinetochore (GO:0008608)	3.69828674
53	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.62700510
54	positive regulation of meiosis (GO:0045836)	3.61009916
55	positive regulation of chromosome segregation (GO:0051984)	3.60458248
56	aggressive behavior (GO:0002118)	3.57952095
57	L-amino acid import (GO:0043092)	3.57163527
58	male meiosis I (GO:0007141)	3.56978971
59	sperm-egg recognition (GO:0035036)	3.56725167
60	type B pancreatic cell development (GO:0003323)	3.54114391
61	negative regulation of hormone metabolic process (GO:0032351)	3.47213120
62	metaphase plate congression (GO:0051310)	3.41429806
63	regulation of histone methylation (GO:0031060)	3.40353629
64	gene silencing (GO:0016458)	3.39223489
65	synaptonemal complex assembly (GO:0007130)	3.36634850
66	positive regulation of meiotic cell cycle (GO:0051446)	3.35299278
67	regulation of meiotic cell cycle (GO:0051445)	3.34521350
68	male meiosis (GO:0007140)	3.34339164
69	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.33514780
70	regulation of phospholipid biosynthetic process (GO:0071071)	3.29755175
71	regulation of corticosteroid hormone secretion (GO:2000846)	3.27990166
72	regulation of chromatin binding (GO:0035561)	3.27784046
73	protein localization to chromosome (GO:0034502)	3.18459976
74	chromosome organization involved in meiosis (GO:0070192)	3.16415609
75	negative regulation of cAMP-mediated signaling (GO:0043951)	3.15351970
76	positive regulation of endothelial cell differentiation (GO:0045603)	3.13475995
77	labyrinthine layer development (GO:0060711)	3.12994954
78	regulation of hypersensitivity (GO:0002883)	3.11243451
79	regulation of DNA endoreduplication (GO:0032875)	3.09454568
80	interkinetic nuclear migration (GO:0022027)	3.09397172
81	cellular response to pH (GO:0071467)	3.08029253
82	stress granule assembly (GO:0034063)	3.07682042
83	meiosis I (GO:0007127)	3.07466707
84	DNA methylation or demethylation (GO:0044728)	3.06270135
85	positive regulation of steroid hormone secretion (GO:2000833)	3.05182734
86	regulation of chromatin silencing (GO:0031935)	3.01725668
87	translesion synthesis (GO:0019985)	3.01554925
88	DNA replication-dependent nucleosome assembly (GO:0006335)	2.99481902
89	DNA replication-dependent nucleosome organization (GO:0034723)	2.99481902
90	meiotic nuclear division (GO:0007126)	2.98731866
91	CENP-A containing nucleosome assembly (GO:0034080)	2.98671049
92	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.98596207
93	N-terminal protein amino acid acetylation (GO:0006474)	2.98218107
94	regulation of spindle organization (GO:0090224)	2.96500329
95	synaptonemal complex organization (GO:0070193)	2.96129491
96	positive regulation of hormone biosynthetic process (GO:0046886)	2.92470342
97	somite rostral/caudal axis specification (GO:0032525)	2.92449037
98	regulation of uterine smooth muscle contraction (GO:0070472)	2.91292095
99	regulation of female gonad development (GO:2000194)	11.2502314
100	regulation of DNA methylation (GO:0044030)	10.1992093

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.27257797
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.00541686
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.69705207
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.07691841
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.56268450
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.56268450
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.56268450
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.51190341
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.31820288
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.31025603
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21942614
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.17631425
13	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.04722834
14	EZH2_22144423_ChIP-Seq_EOC_Human	15.8063496
15	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.90005733
16	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.83904227
17	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.79697274
18	E2F7_22180533_ChIP-Seq_HELA_Human	1.73011127
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.72259091
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67197176
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.43314508
22	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.37668516
23	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.36872185
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35454559
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30399953
26	ZNF274_21170338_ChIP-Seq_K562_Hela	1.29610380
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27215595
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.24105962
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24105962
30	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21319071
31	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.16470508
32	TCF4_23295773_ChIP-Seq_U87_Human	1.15783721
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.14049614
34	AR_25329375_ChIP-Seq_VCAP_Human	1.11567093
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11082348
36	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.09928397
37	EWS_26573619_Chip-Seq_HEK293_Human	1.09133443
38	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08587621
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.08261523
40	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07290454
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05390852
42	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05177224
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04544563
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04011583
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03363930
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03357078
47	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.02201810
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01424214
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00281776
50	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98266085
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98062891
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98062891
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97537665
54	RUNX2_22187159_ChIP-Seq_PCA_Human	0.95265393
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.93743422
56	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92064569
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91465598
58	P300_19829295_ChIP-Seq_ESCs_Human	0.91387552
59	RNF2_27304074_Chip-Seq_NSC_Mouse	0.91222379
60	STAT3_23295773_ChIP-Seq_U87_Human	0.91104132
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90877996
62	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.90350111
63	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.90310377
64	TP53_22573176_ChIP-Seq_HFKS_Human	0.86725456
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.86047944
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.85330977
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.84941102
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.84702957
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.84599371
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.84365429
71	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.81782183
72	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.81779722
73	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.81741905
74	GF1_26923725_Chip-Seq_HPCs_Mouse	0.79538234
75	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.79371210
76	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.77835604
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.75213909
78	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.75173320
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.72608390
80	TAF15_26573619_Chip-Seq_HEK293_Human	0.71900566
81	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.69735039
82	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.69539915
83	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.69406842
84	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.68805086
85	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.68529183
86	CBP_21632823_ChIP-Seq_H3396_Human	0.68064157
87	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.67319731
88	AHR_22903824_ChIP-Seq_MCF-7_Human	0.67039181
89	NCOR_22424771_ChIP-Seq_293T_Human	0.66992427
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.66129013
91	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.66101562
92	SMRT_27268052_Chip-Seq_Bcells_Human	0.65381242
93	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.65222507
94	DROSHA_22980978_ChIP-Seq_HELA_Human	0.65011140
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.64865813
96	VDR_22108803_ChIP-Seq_LS180_Human	0.63495832
97	KLF4_19829295_ChIP-Seq_ESCs_Human	0.63468816
98	SOX2_19829295_ChIP-Seq_ESCs_Human	0.62961245
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.62961245
100	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.62865383

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	7.66816511
2	MP0008877_abnormal_DNA_methylation	4.79956727
3	MP0006292_abnormal_olfactory_placode	4.79276493
4	MP0008789_abnormal_olfactory_epithelium	4.39090639
5	MP0005499_abnormal_olfactory_system	3.99983369
6	MP0005394_taste/olfaction_phenotype	3.99983369
7	MP0002139_abnormal_hepatobiliary_system	2.93344302
8	MP0005395_other_phenotype	2.89427443
9	MP0002138_abnormal_hepatobiliary_system	2.72209719
10	MP0003890_abnormal_embryonic-extraembry	2.71728266
11	MP0002234_abnormal_pharynx_morphology	2.65789561
12	MP0010030_abnormal_orbit_morphology	2.56758146
13	MP0003699_abnormal_female_reproductive	2.40177094
14	MP0008057_abnormal_DNA_replication	2.40059430
15	MP0003693_abnormal_embryo_hatching	2.31830936
16	MP0003879_abnormal_hair_cell	2.24319786
17	MP0001929_abnormal_gametogenesis	2.15586067
18	MP0005646_abnormal_pituitary_gland	2.04106573
19	MP0002210_abnormal_sex_determination	2.02207529
20	MP0003121_genomic_imprinting	1.88083254
21	MP0005360_urolithiasis	1.86586387
22	MP0000631_abnormal_neuroendocrine_gland	1.69888676
23	MP0000653_abnormal_sex_gland	1.68873878
24	MP0003077_abnormal_cell_cycle	1.62709285
25	MP0008058_abnormal_DNA_repair	1.60955802
26	MP0002161_abnormal_fertility/fecundity	1.60909282
27	MP0000566_synostosis	1.59045379
28	MP0001984_abnormal_olfaction	1.53654806
29	MP0001119_abnormal_female_reproductive	1.43746141
30	MP0002160_abnormal_reproductive_system	1.43081798
31	MP0010368_abnormal_lymphatic_system	1.42380767
32	MP0002272_abnormal_nervous_system	1.41350720
33	MP0003183_abnormal_peptide_metabolism	1.41204594
34	MP0005410_abnormal_fertilization	1.39868375
35	MP0000049_abnormal_middle_ear	1.35360527
36	MP0003119_abnormal_digestive_system	1.32159693
37	MP0010094_abnormal_chromosome_stability	1.30498960
38	MP0003136_yellow_coat_color	1.30081182
39	MP0005389_reproductive_system_phenotype	1.26429556
40	MP0003252_abnormal_bile_duct	1.23660286
41	MP0006276_abnormal_autonomic_nervous	1.23183874
42	MP0004142_abnormal_muscle_tone	1.23054901
43	MP0005551_abnormal_eye_electrophysiolog	1.22598383
44	MP0002233_abnormal_nose_morphology	1.22291543
45	MP0001145_abnormal_male_reproductive	1.20935286
46	MP0010234_abnormal_vibrissa_follicle	1.20773429
47	MP0001293_anophthalmia	1.17633984
48	MP0003950_abnormal_plasma_membrane	1.16338835
49	MP0003111_abnormal_nucleus_morphology	1.14409893
50	MP0001986_abnormal_taste_sensitivity	1.05912097
51	MP0008932_abnormal_embryonic_tissue	1.03856137
52	MP0000762_abnormal_tongue_morphology	1.03182689
53	MP0003698_abnormal_male_reproductive	1.02671671
54	MP0001502_abnormal_circadian_rhythm	1.01662601
55	MP0000427_abnormal_hair_cycle	1.00389633
56	MP0010307_abnormal_tumor_latency	0.97080496
57	MP0001730_embryonic_growth_arrest	0.94621916
58	MP0005647_abnormal_sex_gland	0.92753358
59	MP0003880_abnormal_central_pattern	0.89842314
60	MP0000678_abnormal_parathyroid_gland	0.88758154
61	MP0006072_abnormal_retinal_apoptosis	0.85754292
62	MP0005409_darkened_coat_color	0.80178143
63	MP0009840_abnormal_foam_cell	0.78972381
64	MP0008995_early_reproductive_senescence	0.76644554
65	MP0001963_abnormal_hearing_physiology	0.74999414
66	MP0010678_abnormal_skin_adnexa	0.74232810
67	MP0001664_abnormal_digestion	0.74160440
68	MP0005187_abnormal_penis_morphology	0.73171012
69	MP0001529_abnormal_vocalization	0.72988659
70	MP0002735_abnormal_chemical_nociception	0.71574059
71	MP0002751_abnormal_autonomic_nervous	0.71537362
72	MP0001324_abnormal_eye_pigmentation	0.68264321
73	MP0000026_abnormal_inner_ear	0.67813365
74	MP0002928_abnormal_bile_duct	0.67103315
75	MP0005380_embryogenesis_phenotype	0.66980034
76	MP0001672_abnormal_embryogenesis/_devel	0.66980034
77	MP0003635_abnormal_synaptic_transmissio	0.66811477
78	MP0002734_abnormal_mechanical_nocicepti	0.66351443
79	MP0001919_abnormal_reproductive_system	0.64825149
80	MP0000372_irregular_coat_pigmentation	0.64168826
81	MP0009379_abnormal_foot_pigmentation	0.62439210
82	MP0001486_abnormal_startle_reflex	0.61210073
83	MP0005085_abnormal_gallbladder_physiolo	0.60809398
84	MP0009745_abnormal_behavioral_response	0.59374418
85	MP0003755_abnormal_palate_morphology	0.56717626
86	MP0002084_abnormal_developmental_patter	0.55513067
87	MP0003959_abnormal_lean_body	0.55069894
88	MP0002089_abnormal_postnatal_growth/wei	0.54806310
89	MP0002572_abnormal_emotion/affect_behav	0.53737032
90	MP0001666_abnormal_nutrient_absorption	0.53523799
91	MP0002063_abnormal_learning/memory/cond	0.52667817
92	MP0003935_abnormal_craniofacial_develop	0.50659559
93	MP0000428_abnormal_craniofacial_morphol	0.49570961
94	MP0002638_abnormal_pupillary_reflex	0.49558032
95	MP0000383_abnormal_hair_follicle	0.49206562
96	MP0002752_abnormal_somatic_nervous	0.49074071
97	MP0000778_abnormal_nervous_system	0.48284246
98	MP0003861_abnormal_nervous_system	0.46750168
99	MP0002557_abnormal_social/conspecific_i	0.46591123
100	MP0004811_abnormal_neuron_physiology	0.46396331

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.84399832
2	Supernumerary spleens (HP:0009799)	5.39967121
3	Septo-optic dysplasia (HP:0100842)	5.02341754
4	Abnormality of abdominal situs (HP:0011620)	4.91189643
5	Abdominal situs inversus (HP:0003363)	4.91189643
6	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.89819757
7	Hypoplasia of the fovea (HP:0007750)	4.89819757
8	Anterior segment dysgenesis (HP:0007700)	4.77195157
9	Impulsivity (HP:0100710)	4.62164790
10	Osteomalacia (HP:0002749)	4.25575317
11	Cholecystitis (HP:0001082)	4.25284227
12	Abnormal gallbladder physiology (HP:0012438)	4.25284227
13	Lip pit (HP:0100267)	4.08526104
14	Abnormality of the fovea (HP:0000493)	4.06837473
15	Short tibia (HP:0005736)	3.96666928
16	Facial hemangioma (HP:0000329)	3.78087660
17	Male infertility (HP:0003251)	3.69571539
18	Absent septum pellucidum (HP:0001331)	3.67856177
19	Hypophosphatemic rickets (HP:0004912)	3.54117538
20	Infertility (HP:0000789)	3.50648226
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.50485547
22	Oligodactyly (hands) (HP:0001180)	3.49500290
23	Abnormality of the labia minora (HP:0012880)	3.42431010
24	Papillary thyroid carcinoma (HP:0002895)	3.34869387
25	Median cleft lip (HP:0000161)	3.27397364
26	Apathy (HP:0000741)	3.04861594
27	Abnormality of the septum pellucidum (HP:0007375)	3.02471388
28	Hypokinesia (HP:0002375)	3.01993543
29	Gonadotropin excess (HP:0000837)	3.01285778
30	Diminished motivation (HP:0000745)	2.99471913
31	Aplasia/Hypoplasia of the macula (HP:0008059)	2.95420178
32	Azoospermia (HP:0000027)	2.95420026
33	Premature ovarian failure (HP:0008209)	2.94914662
34	Chromsome breakage (HP:0040012)	2.88393948
35	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.85265861
36	Myokymia (HP:0002411)	2.84117299
37	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.72709474
38	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.71897948
39	Skin pits (HP:0100276)	2.59147425
40	Oligodactyly (HP:0012165)	2.55537532
41	Truncal obesity (HP:0001956)	2.53899251
42	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.50634679
43	Optic nerve hypoplasia (HP:0000609)	2.41799590
44	Aplasia of the musculature (HP:0100854)	2.40580753
45	Molar tooth sign on MRI (HP:0002419)	2.36579343
46	Abnormality of midbrain morphology (HP:0002418)	2.36579343
47	Dysdiadochokinesis (HP:0002075)	2.34557656
48	Abnormal biliary tract physiology (HP:0012439)	2.34036290
49	Bile duct proliferation (HP:0001408)	2.34036290
50	Capillary hemangiomas (HP:0005306)	2.24919230
51	Striae distensae (HP:0001065)	2.24273345
52	Wrist flexion contracture (HP:0001239)	2.22955927
53	Abnormal lung lobation (HP:0002101)	2.21371178
54	Malnutrition (HP:0004395)	2.21291988
55	Maternal diabetes (HP:0009800)	2.19515265
56	Lower limb hyperreflexia (HP:0002395)	2.17592790
57	Generalized aminoaciduria (HP:0002909)	2.17460146
58	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.17210244
59	Muscle stiffness (HP:0003552)	2.17177952
60	Abnormal ciliary motility (HP:0012262)	2.15535367
61	Preauricular pit (HP:0004467)	2.15430300
62	Periauricular skin pits (HP:0100277)	2.15430300
63	Hypergonadotropic hypogonadism (HP:0000815)	2.14009900
64	Abnormal spermatogenesis (HP:0008669)	2.11359891
65	Congenital sensorineural hearing impairment (HP:0008527)	2.09253437
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.05562726
67	Pendular nystagmus (HP:0012043)	2.00429395
68	Fair hair (HP:0002286)	1.98941165
69	Severe visual impairment (HP:0001141)	1.98491815
70	Bundle branch block (HP:0011710)	1.98462221
71	Abnormality of the anterior chamber (HP:0000593)	1.97050556
72	Anhidrosis (HP:0000970)	1.91262486
73	Anomalous pulmonary venous return (HP:0010772)	1.91068612
74	Increased circulating renin level (HP:0000848)	1.90433563
75	Metaphyseal irregularity (HP:0003025)	1.89981767
76	Abnormal respiratory motile cilium physiology (HP:0012261)	1.88061550
77	Spinal cord compression (HP:0002176)	1.87643140
78	Stillbirth (HP:0003826)	1.84792997
79	Enlarged penis (HP:0000040)	1.83720113
80	Gaze-evoked nystagmus (HP:0000640)	1.83434963
81	Proximal tubulopathy (HP:0000114)	1.83010245
82	Chronic hepatic failure (HP:0100626)	1.82921941
83	Thyroid carcinoma (HP:0002890)	1.80314819
84	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80295947
85	Abnormality of the phalanges of the hallux (HP:0010057)	1.76927993
86	Decreased circulating renin level (HP:0003351)	1.76565898
87	Intrahepatic cholestasis (HP:0001406)	1.74834102
88	Thyroid-stimulating hormone excess (HP:0002925)	1.73877199
89	Hypohidrosis (HP:0000966)	1.70785436
90	Pancreatic cysts (HP:0001737)	1.70607039
91	Posterior subcapsular cataract (HP:0007787)	1.69640341
92	Urethral obstruction (HP:0000796)	1.68851285
93	Spinal canal stenosis (HP:0003416)	1.65949169
94	Abnormality of DNA repair (HP:0003254)	1.65816956
95	Abnormality of chromosome segregation (HP:0002916)	1.65241759
96	Pancreatic fibrosis (HP:0100732)	1.64463347
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.63997423
98	Absent/shortened dynein arms (HP:0200106)	1.63997423
99	Heterotopia (HP:0002282)	1.63990007
100	Abnormality of chromosome stability (HP:0003220)	1.63887594

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.45651998
2	ARAF	5.23816021
3	MAP3K13	4.47583467
4	NEK6	3.37638343
5	TAOK3	3.01581467
6	CDK19	2.74825688
7	AURKA	2.62302462
8	CDK12	2.49210381
9	TTK	2.46359127
10	STK24	2.39754907
11	TRIM28	2.38179879
12	BRAF	2.34228905
13	CDK9	2.29155556
14	NTRK2	2.17530512
15	CDC7	2.15707254
16	MOS	2.08771810
17	MET	2.06497537
18	PRKCI	1.89574729
19	MELK	1.72918599
20	CDK7	1.56870262
21	EIF2AK3	1.56611574
22	MAP4K2	1.52384055
23	TNIK	1.51290473
24	RAF1	1.49629522
25	NUAK1	1.47559553
26	BUB1	1.31385445
27	EPHA4	1.25642445
28	CSNK1G1	1.25288260
29	NEK9	1.23588966
30	CSNK1G3	1.20426217
31	PLK1	1.18347045
32	CDK8	1.12634806
33	KSR2	1.12256577
34	KSR1	1.06364266
35	BRSK1	1.05916640
36	CSNK1A1L	1.01016669
37	CSNK1G2	0.99998813
38	TIE1	0.97184841
39	NME2	0.92047669
40	PIM1	0.91539995
41	WNK1	0.91428796
42	CHEK1	0.89156866
43	BMPR1B	0.86700240
44	TNK2	0.84338981
45	MAPK13	0.82140189
46	PTK2	0.81926747
47	PRKCZ	0.77812224
48	MAP3K5	0.77678960
49	STK39	0.76361528
50	CDK2	0.76225607
51	VRK1	0.74937256
52	NEK2	0.72206598
53	SRPK1	0.72113565
54	TLK1	0.71904056
55	CSNK1D	0.71051229
56	PLK3	0.66202110
57	STK3	0.64959734
58	TGFBR1	0.64579442
59	ATR	0.63239396
60	ATM	0.63194123
61	MAP3K8	0.62948429
62	AURKB	0.62794961
63	DMPK	0.58858307
64	PRKG1	0.57222511
65	PAK1	0.55565759
66	MARK3	0.55220226
67	CAMK2A	0.54147770
68	CDK5	0.54066716
69	CHEK2	0.53216492
70	PKN1	0.51940338
71	MAP3K4	0.50776730
72	CDK1	0.50055850
73	ZAK	0.48976125
74	MTOR	0.43163375
75	TESK2	0.43001312
76	PRKACA	0.40834315
77	CSNK1E	0.40694338
78	CHUK	0.39263578
79	WNK3	0.37167985
80	VRK2	0.36269115
81	NTRK3	0.35036482
82	PRKACB	0.34786692
83	LMTK2	0.34119616
84	GSK3B	0.31695326
85	CAMK4	0.31067976
86	CLK1	0.29110046
87	PRKD3	0.29012450
88	CDK11A	0.28354067
89	PDK1	0.26251257
90	RPS6KB1	0.26198039
91	WNK4	0.25757579
92	MAPKAPK5	0.24926009
93	MAPK10	0.24378610
94	MAPK1	0.24190375
95	CAMK1D	0.23730585
96	EPHB1	0.23618375
97	MAPKAPK3	0.23067086
98	MARK2	0.22454982
99	DYRK2	0.22397562
100	OXSR1	0.20678296

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.08208984
2	Cell cycle_Homo sapiens_hsa04110	3.77461414
3	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.49911905
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.36395372
5	Oocyte meiosis_Homo sapiens_hsa04114	3.20263742
6	Caffeine metabolism_Homo sapiens_hsa00232	3.18782918
7	Phototransduction_Homo sapiens_hsa04744	2.95986760
8	Mismatch repair_Homo sapiens_hsa03430	2.95475998
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.81089504
10	RNA degradation_Homo sapiens_hsa03018	2.68280122
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.42455411
12	Base excision repair_Homo sapiens_hsa03410	2.37173468
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.22000708
14	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.18425680
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.07573074
16	Nicotine addiction_Homo sapiens_hsa05033	2.05971317
17	Nucleotide excision repair_Homo sapiens_hsa03420	2.01672954
18	Olfactory transduction_Homo sapiens_hsa04740	1.98246582
19	Homologous recombination_Homo sapiens_hsa03440	1.86742568
20	Circadian rhythm_Homo sapiens_hsa04710	1.81458894
21	DNA replication_Homo sapiens_hsa03030	1.73830602
22	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.70186696
23	RNA transport_Homo sapiens_hsa03013	1.67514494
24	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.65577864
25	Gap junction_Homo sapiens_hsa04540	1.57341357
26	Morphine addiction_Homo sapiens_hsa05032	1.47819516
27	p53 signaling pathway_Homo sapiens_hsa04115	1.47077533
28	GABAergic synapse_Homo sapiens_hsa04727	1.43967541
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38471244
30	RNA polymerase_Homo sapiens_hsa03020	1.31370519
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.30439495
32	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.24722135
33	Folate biosynthesis_Homo sapiens_hsa00790	1.16063118
34	ABC transporters_Homo sapiens_hsa02010	1.06883579
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97888315
36	mRNA surveillance pathway_Homo sapiens_hsa03015	0.96421635
37	Huntingtons disease_Homo sapiens_hsa05016	0.95668457
38	Taste transduction_Homo sapiens_hsa04742	0.91283203
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84217436
40	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.77263305
41	Fatty acid elongation_Homo sapiens_hsa00062	0.71561515
42	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.70726884
43	Regulation of autophagy_Homo sapiens_hsa04140	0.69777485
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.66997872
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64456316
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.64004750
47	Bile secretion_Homo sapiens_hsa04976	0.62530977
48	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.62197151
49	Thyroid cancer_Homo sapiens_hsa05216	0.62001609
50	mTOR signaling pathway_Homo sapiens_hsa04150	0.61423835
51	Purine metabolism_Homo sapiens_hsa00230	0.57895019
52	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.55177221
53	Serotonergic synapse_Homo sapiens_hsa04726	0.51223456
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49713024
55	Insulin secretion_Homo sapiens_hsa04911	0.48922310
56	Hippo signaling pathway_Homo sapiens_hsa04390	0.47019055
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46965528
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46636897
59	Spliceosome_Homo sapiens_hsa03040	0.45288043
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45048802
61	Long-term depression_Homo sapiens_hsa04730	0.44153757
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42634366
63	Circadian entrainment_Homo sapiens_hsa04713	0.42498694
64	Wnt signaling pathway_Homo sapiens_hsa04310	0.41460486
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.41393898
66	Cholinergic synapse_Homo sapiens_hsa04725	0.39219894
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.35486539
68	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.34878856
69	Arginine biosynthesis_Homo sapiens_hsa00220	0.34548172
70	MicroRNAs in cancer_Homo sapiens_hsa05206	0.33395018
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.32754609
72	FoxO signaling pathway_Homo sapiens_hsa04068	0.31973500
73	Ras signaling pathway_Homo sapiens_hsa04014	0.30916376
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.30717939
75	Viral carcinogenesis_Homo sapiens_hsa05203	0.28972846
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28684140
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26826083
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.23081109
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.22589822
80	Herpes simplex infection_Homo sapiens_hsa05168	0.22025459
81	Salivary secretion_Homo sapiens_hsa04970	0.21916316
82	Gastric acid secretion_Homo sapiens_hsa04971	0.21701797
83	Parkinsons disease_Homo sapiens_hsa05012	0.20666066
84	Phagosome_Homo sapiens_hsa04145	0.20287169
85	Amphetamine addiction_Homo sapiens_hsa05031	0.19823610
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.18162063
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.17852191
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.17768160
89	Adherens junction_Homo sapiens_hsa04520	0.17256803
90	MAPK signaling pathway_Homo sapiens_hsa04010	0.14890223
91	Protein digestion and absorption_Homo sapiens_hsa04974	0.13305303
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.13068691
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.12923814
94	Oxidative phosphorylation_Homo sapiens_hsa00190	0.12297307
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.11945268
96	Protein export_Homo sapiens_hsa03060	0.09561114
97	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.09447732
98	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.09389358
99	Rap1 signaling pathway_Homo sapiens_hsa04015	0.09068232
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.08244285

TUBB8P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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