

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.83034638 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 4.73635700 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.73635700 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.39398517 |
| 5 | sequestering of actin monomers (GO:0042989) | 4.21610028 |
| 6 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.07196716 |
| 7 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.07196716 |
| 8 | NADH dehydrogenase complex assembly (GO:0010257) | 4.07196716 |
| 9 | GTP biosynthetic process (GO:0006183) | 4.00046521 |
| 10 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.97615873 |
| 11 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.96707547 |
| 12 | protein complex biogenesis (GO:0070271) | 3.76670209 |
| 13 | proteasome assembly (GO:0043248) | 3.65010739 |
| 14 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.59530101 |
| 15 | DNA double-strand break processing (GO:0000729) | 3.58086608 |
| 16 | UTP biosynthetic process (GO:0006228) | 3.52433335 |
| 17 | chaperone-mediated protein transport (GO:0072321) | 3.52366230 |
| 18 | cullin deneddylation (GO:0010388) | 3.44582280 |
| 19 | respiratory electron transport chain (GO:0022904) | 3.40428127 |
| 20 | DNA damage response, detection of DNA damage (GO:0042769) | 3.39613984 |
| 21 | UTP metabolic process (GO:0046051) | 3.39364495 |
| 22 | electron transport chain (GO:0022900) | 3.38919504 |
| 23 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.37253800 |
| 24 | chromatin remodeling at centromere (GO:0031055) | 3.36431601 |
| 25 | behavioral response to nicotine (GO:0035095) | 3.32753680 |
| 26 | protein deneddylation (GO:0000338) | 3.28816526 |
| 27 | protein neddylation (GO:0045116) | 3.28672962 |
| 28 | CENP-A containing nucleosome assembly (GO:0034080) | 3.27398577 |
| 29 | nucleobase catabolic process (GO:0046113) | 3.26978372 |
| 30 | spliceosomal snRNP assembly (GO:0000387) | 3.24156035 |
| 31 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.19681023 |
| 32 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.19681023 |
| 33 | ubiquinone metabolic process (GO:0006743) | 3.17367990 |
| 34 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.17119564 |
| 35 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.16414941 |
| 36 | regulation of mitochondrial translation (GO:0070129) | 3.15317829 |
| 37 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.14379150 |
| 38 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.13197791 |
| 39 | protein-cofactor linkage (GO:0018065) | 3.12553971 |
| 40 | CTP biosynthetic process (GO:0006241) | 3.12252824 |
| 41 | CTP metabolic process (GO:0046036) | 3.12252824 |
| 42 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.10930013 |
| 43 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.09359010 |
| 44 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.05009204 |
| 45 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.02879872 |
| 46 | platelet dense granule organization (GO:0060155) | 2.97647777 |
| 47 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.96091729 |
| 48 | DNA deamination (GO:0045006) | 2.92510183 |
| 49 | organelle disassembly (GO:1903008) | 2.91061546 |
| 50 | DNA replication checkpoint (GO:0000076) | 2.89919309 |
| 51 | pseudouridine synthesis (GO:0001522) | 2.89440602 |
| 52 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.89414042 |
| 53 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.88249051 |
| 54 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.86403185 |
| 55 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.85713293 |
| 56 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.85713293 |
| 57 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.85662748 |
| 58 | replication fork processing (GO:0031297) | 2.84920203 |
| 59 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.82742950 |
| 60 | ubiquinone biosynthetic process (GO:0006744) | 2.82579639 |
| 61 | postreplication repair (GO:0006301) | 2.82004076 |
| 62 | isoprenoid biosynthetic process (GO:0008299) | 2.81464823 |
| 63 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.78963941 |
| 64 | negative regulation of ligase activity (GO:0051352) | 2.78963941 |
| 65 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.78536978 |
| 66 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 2.76781194 |
| 67 | DNA strand elongation (GO:0022616) | 2.76397150 |
| 68 | maturation of 5.8S rRNA (GO:0000460) | 2.76374133 |
| 69 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.75585865 |
| 70 | 7-methylguanosine mRNA capping (GO:0006370) | 2.73635436 |
| 71 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.73331193 |
| 72 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.73322505 |
| 73 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.73255230 |
| 74 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.73244789 |
| 75 | positive regulation of mitochondrial fission (GO:0090141) | 2.73038530 |
| 76 | termination of RNA polymerase III transcription (GO:0006386) | 2.72569738 |
| 77 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.72569738 |
| 78 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.72374155 |
| 79 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.72374155 |
| 80 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.72374155 |
| 81 | ATP biosynthetic process (GO:0006754) | 2.72195666 |
| 82 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.70717600 |
| 83 | peptidyl-histidine modification (GO:0018202) | 2.68636858 |
| 84 | respiratory chain complex IV assembly (GO:0008535) | 2.68593090 |
| 85 | gamma-aminobutyric acid transport (GO:0015812) | 2.67233413 |
| 86 | 7-methylguanosine RNA capping (GO:0009452) | 2.66554726 |
| 87 | RNA capping (GO:0036260) | 2.66554726 |
| 88 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.66503336 |
| 89 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.66503336 |
| 90 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.65577427 |
| 91 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.65577427 |
| 92 | de novo posttranslational protein folding (GO:0051084) | 2.64950998 |
| 93 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.63343106 |
| 94 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.62599217 |
| 95 | inner mitochondrial membrane organization (GO:0007007) | 2.62004493 |
| 96 | de novo protein folding (GO:0006458) | 2.60827344 |
| 97 | translesion synthesis (GO:0019985) | 2.59276180 |
| 98 | L-methionine salvage (GO:0071267) | 2.59018921 |
| 99 | L-methionine biosynthetic process (GO:0071265) | 2.59018921 |
| 100 | amino acid salvage (GO:0043102) | 2.59018921 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.72636834 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.98938699 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.64303310 |
| 4 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.30784505 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.29127932 |
| 6 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.09425527 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.04448853 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.91477822 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.83499140 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.76103912 |
| 11 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.67208525 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.65837318 |
| 13 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.52452728 |
| 14 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.48013669 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.44881482 |
| 16 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.41476995 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.40307097 |
| 18 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.30358989 |
| 19 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.28945591 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.23206456 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 2.11051268 |
| 22 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.08504486 |
| 23 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.07940567 |
| 24 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.05239378 |
| 25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.04087769 |
| 26 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.99178661 |
| 27 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.96960639 |
| 28 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.96507221 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.85488924 |
| 30 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.83865642 |
| 31 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.83274564 |
| 32 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.82190494 |
| 33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.77040986 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.76851362 |
| 35 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.75061252 |
| 36 | EWS_26573619_Chip-Seq_HEK293_Human | 1.69973294 |
| 37 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.69582601 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.66712803 |
| 39 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.63788788 |
| 40 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.63030295 |
| 41 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.59611829 |
| 42 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.59111060 |
| 43 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.55370174 |
| 44 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.52481327 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.51191933 |
| 46 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.49404893 |
| 47 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.48386615 |
| 48 | FUS_26573619_Chip-Seq_HEK293_Human | 1.44752472 |
| 49 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.44636631 |
| 50 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.44503493 |
| 51 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.44307635 |
| 52 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.44011040 |
| 53 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.40258116 |
| 54 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.35264615 |
| 55 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.34498229 |
| 56 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.32127967 |
| 57 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.30967263 |
| 58 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.30886401 |
| 59 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.29488600 |
| 60 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.27187496 |
| 61 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.27128850 |
| 62 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.26218659 |
| 63 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.25740493 |
| 64 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.21150877 |
| 65 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.18610866 |
| 66 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.17143555 |
| 67 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.16709422 |
| 68 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.15612315 |
| 69 | P300_19829295_ChIP-Seq_ESCs_Human | 1.14077733 |
| 70 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.12244878 |
| 71 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10734568 |
| 72 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.10694019 |
| 73 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.10547247 |
| 74 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.08910252 |
| 75 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.07607553 |
| 76 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.07545670 |
| 77 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.06290964 |
| 78 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.05304844 |
| 79 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.04097502 |
| 80 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.01872271 |
| 81 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.01509470 |
| 82 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.00522536 |
| 83 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.00043358 |
| 84 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.99851132 |
| 85 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.98262016 |
| 86 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.92105826 |
| 87 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.91748181 |
| 88 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.90933375 |
| 89 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.90342018 |
| 90 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.88857181 |
| 91 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.87542454 |
| 92 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.87002887 |
| 93 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.86782216 |
| 94 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.82966844 |
| 95 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.80986252 |
| 96 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.80565569 |
| 97 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.79000691 |
| 98 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.78752203 |
| 99 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.78614624 |
| 100 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.78046703 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 3.36894925 |
| 2 | MP0001529_abnormal_vocalization | 3.12603942 |
| 3 | MP0000372_irregular_coat_pigmentation | 2.64306082 |
| 4 | MP0006292_abnormal_olfactory_placode | 2.63434466 |
| 5 | MP0008058_abnormal_DNA_repair | 2.59076995 |
| 6 | MP0008789_abnormal_olfactory_epithelium | 2.49271444 |
| 7 | MP0005394_taste/olfaction_phenotype | 2.27026631 |
| 8 | MP0005499_abnormal_olfactory_system | 2.27026631 |
| 9 | MP0003880_abnormal_central_pattern | 2.21087661 |
| 10 | MP0003122_maternal_imprinting | 2.14562355 |
| 11 | MP0010094_abnormal_chromosome_stability | 2.12956873 |
| 12 | MP0003693_abnormal_embryo_hatching | 2.12780907 |
| 13 | MP0005084_abnormal_gallbladder_morpholo | 2.09121134 |
| 14 | MP0002653_abnormal_ependyma_morphology | 1.97690782 |
| 15 | MP0002234_abnormal_pharynx_morphology | 1.92907022 |
| 16 | MP0002938_white_spotting | 1.92117004 |
| 17 | MP0006276_abnormal_autonomic_nervous | 1.87776993 |
| 18 | MP0000566_synostosis | 1.83209909 |
| 19 | MP0004142_abnormal_muscle_tone | 1.79872113 |
| 20 | MP0003121_genomic_imprinting | 1.77640204 |
| 21 | MP0002736_abnormal_nociception_after | 1.74907530 |
| 22 | MP0000049_abnormal_middle_ear | 1.73497558 |
| 23 | MP0001984_abnormal_olfaction | 1.69082433 |
| 24 | MP0000778_abnormal_nervous_system | 1.68459738 |
| 25 | MP0006072_abnormal_retinal_apoptosis | 1.59802214 |
| 26 | MP0005187_abnormal_penis_morphology | 1.59229496 |
| 27 | MP0008995_early_reproductive_senescence | 1.58642590 |
| 28 | MP0001986_abnormal_taste_sensitivity | 1.58288798 |
| 29 | MP0005423_abnormal_somatic_nervous | 1.55776176 |
| 30 | MP0004957_abnormal_blastocyst_morpholog | 1.55752183 |
| 31 | MP0004133_heterotaxia | 1.52872129 |
| 32 | MP0003718_maternal_effect | 1.48866430 |
| 33 | MP0006035_abnormal_mitochondrial_morpho | 1.47973786 |
| 34 | MP0005551_abnormal_eye_electrophysiolog | 1.47323847 |
| 35 | MP0003786_premature_aging | 1.46079723 |
| 36 | MP0002822_catalepsy | 1.44931614 |
| 37 | MP0008875_abnormal_xenobiotic_pharmacok | 1.41452866 |
| 38 | MP0003011_delayed_dark_adaptation | 1.40597309 |
| 39 | MP0001293_anophthalmia | 1.40013343 |
| 40 | MP0009697_abnormal_copulation | 1.39907338 |
| 41 | MP0008932_abnormal_embryonic_tissue | 1.38006535 |
| 42 | MP0003111_abnormal_nucleus_morphology | 1.37041467 |
| 43 | MP0003937_abnormal_limbs/digits/tail_de | 1.36027976 |
| 44 | MP0003119_abnormal_digestive_system | 1.34708735 |
| 45 | MP0010030_abnormal_orbit_morphology | 1.33197316 |
| 46 | MP0005253_abnormal_eye_physiology | 1.33047420 |
| 47 | MP0009745_abnormal_behavioral_response | 1.32703253 |
| 48 | MP0008877_abnormal_DNA_methylation | 1.29745113 |
| 49 | MP0000631_abnormal_neuroendocrine_gland | 1.27282458 |
| 50 | MP0005645_abnormal_hypothalamus_physiol | 1.27031867 |
| 51 | MP0001968_abnormal_touch/_nociception | 1.21708130 |
| 52 | MP0002751_abnormal_autonomic_nervous | 1.20299762 |
| 53 | MP0003890_abnormal_embryonic-extraembry | 1.19598609 |
| 54 | MP0008872_abnormal_physiological_respon | 1.17688474 |
| 55 | MP0003077_abnormal_cell_cycle | 1.16242862 |
| 56 | MP0009046_muscle_twitch | 1.14697956 |
| 57 | MP0003938_abnormal_ear_development | 1.13651194 |
| 58 | MP0002557_abnormal_social/conspecific_i | 1.13026243 |
| 59 | MP0002233_abnormal_nose_morphology | 1.11927029 |
| 60 | MP0001905_abnormal_dopamine_level | 1.11212928 |
| 61 | MP0000647_abnormal_sebaceous_gland | 1.10461284 |
| 62 | MP0003806_abnormal_nucleotide_metabolis | 1.09568897 |
| 63 | MP0002735_abnormal_chemical_nociception | 1.07199661 |
| 64 | MP0002272_abnormal_nervous_system | 1.07158301 |
| 65 | MP0002210_abnormal_sex_determination | 1.05171170 |
| 66 | MP0002282_abnormal_trachea_morphology | 1.03758720 |
| 67 | MP0002572_abnormal_emotion/affect_behav | 1.03156676 |
| 68 | MP0004147_increased_porphyrin_level | 1.03002699 |
| 69 | MP0003315_abnormal_perineum_morphology | 1.00904127 |
| 70 | MP0003635_abnormal_synaptic_transmissio | 0.99279174 |
| 71 | MP0002752_abnormal_somatic_nervous | 0.98158761 |
| 72 | MP0000026_abnormal_inner_ear | 0.97040590 |
| 73 | MP0003136_yellow_coat_color | 0.96504185 |
| 74 | MP0002184_abnormal_innervation | 0.95773988 |
| 75 | MP0000537_abnormal_urethra_morphology | 0.95548691 |
| 76 | MP0001286_abnormal_eye_development | 0.95241322 |
| 77 | MP0001764_abnormal_homeostasis | 0.93276983 |
| 78 | MP0003698_abnormal_male_reproductive | 0.91823619 |
| 79 | MP0005195_abnormal_posterior_eye | 0.91634664 |
| 80 | MP0002638_abnormal_pupillary_reflex | 0.89951774 |
| 81 | MP0003186_abnormal_redox_activity | 0.88853203 |
| 82 | MP0000653_abnormal_sex_gland | 0.88630425 |
| 83 | MP0001929_abnormal_gametogenesis | 0.88415780 |
| 84 | MP0003567_abnormal_fetal_cardiomyocyte | 0.88338067 |
| 85 | MP0002734_abnormal_mechanical_nocicepti | 0.88195795 |
| 86 | MP0006036_abnormal_mitochondrial_physio | 0.85559828 |
| 87 | MP0004742_abnormal_vestibular_system | 0.84550118 |
| 88 | MP0005171_absent_coat_pigmentation | 0.84450402 |
| 89 | MP0002160_abnormal_reproductive_system | 0.83999065 |
| 90 | MP0003221_abnormal_cardiomyocyte_apopto | 0.83261076 |
| 91 | MP0005391_vision/eye_phenotype | 0.82412159 |
| 92 | MP0003755_abnormal_palate_morphology | 0.81582665 |
| 93 | MP0000579_abnormal_nail_morphology | 0.81129003 |
| 94 | MP0005389_reproductive_system_phenotype | 0.80260558 |
| 95 | MP0000955_abnormal_spinal_cord | 0.80247217 |
| 96 | MP0001919_abnormal_reproductive_system | 0.80047010 |
| 97 | MP0002064_seizures | 0.79986630 |
| 98 | MP0003861_abnormal_nervous_system | 0.79120398 |
| 99 | MP0001145_abnormal_male_reproductive | 0.79083027 |
| 100 | MP0004270_analgesia | 0.76668109 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.76159263 |
| 2 | Acute encephalopathy (HP:0006846) | 4.31271813 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.19518501 |
| 4 | Abnormality of the labia minora (HP:0012880) | 4.15723941 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.11642722 |
| 6 | Increased CSF lactate (HP:0002490) | 3.87986672 |
| 7 | Progressive macrocephaly (HP:0004481) | 3.77333730 |
| 8 | Hepatocellular necrosis (HP:0001404) | 3.49584941 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.46113601 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.32935291 |
| 11 | Hepatic necrosis (HP:0002605) | 3.14953493 |
| 12 | Cerebral edema (HP:0002181) | 3.03583847 |
| 13 | Pancreatic cysts (HP:0001737) | 3.02354283 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 2.99848961 |
| 15 | Pancreatic fibrosis (HP:0100732) | 2.98295450 |
| 16 | True hermaphroditism (HP:0010459) | 2.93745396 |
| 17 | Cortical dysplasia (HP:0002539) | 2.92629836 |
| 18 | Retinal dysplasia (HP:0007973) | 2.88266736 |
| 19 | Lissencephaly (HP:0001339) | 2.85260094 |
| 20 | Increased serum pyruvate (HP:0003542) | 2.80193997 |
| 21 | Abnormality of midbrain morphology (HP:0002418) | 2.78079903 |
| 22 | Molar tooth sign on MRI (HP:0002419) | 2.78079903 |
| 23 | Renal Fanconi syndrome (HP:0001994) | 2.72810662 |
| 24 | Increased serum lactate (HP:0002151) | 2.72716364 |
| 25 | Optic disc pallor (HP:0000543) | 2.57604369 |
| 26 | Nephronophthisis (HP:0000090) | 2.57133475 |
| 27 | Colon cancer (HP:0003003) | 2.54430406 |
| 28 | Hyperglycinemia (HP:0002154) | 2.52634704 |
| 29 | Lactic acidosis (HP:0003128) | 2.48695837 |
| 30 | Abnormality of glycolysis (HP:0004366) | 2.48444072 |
| 31 | Leukodystrophy (HP:0002415) | 2.40580243 |
| 32 | Type II lissencephaly (HP:0007260) | 2.35228271 |
| 33 | Medial flaring of the eyebrow (HP:0010747) | 2.32584008 |
| 34 | Patellar aplasia (HP:0006443) | 2.29462508 |
| 35 | Abnormality of the anterior horn cell (HP:0006802) | 2.27079252 |
| 36 | Degeneration of anterior horn cells (HP:0002398) | 2.27079252 |
| 37 | Hypoplasia of the brainstem (HP:0002365) | 2.27036831 |
| 38 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.27036831 |
| 39 | Respiratory failure (HP:0002878) | 2.21484296 |
| 40 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.16721322 |
| 41 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.15781393 |
| 42 | Abnormality of alanine metabolism (HP:0010916) | 2.11708577 |
| 43 | Hyperalaninemia (HP:0003348) | 2.11708577 |
| 44 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.11708577 |
| 45 | Meckel diverticulum (HP:0002245) | 2.11349374 |
| 46 | Abnormality of the ileum (HP:0001549) | 2.10916002 |
| 47 | Abnormal number of erythroid precursors (HP:0012131) | 2.10200898 |
| 48 | Pendular nystagmus (HP:0012043) | 2.09772807 |
| 49 | Pachygyria (HP:0001302) | 2.09404736 |
| 50 | Sclerocornea (HP:0000647) | 2.09098218 |
| 51 | Exercise intolerance (HP:0003546) | 2.09026519 |
| 52 | Congenital stationary night blindness (HP:0007642) | 2.07659736 |
| 53 | Inability to walk (HP:0002540) | 2.04559411 |
| 54 | Gait imbalance (HP:0002141) | 2.04454298 |
| 55 | Occipital encephalocele (HP:0002085) | 2.00194891 |
| 56 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.99944114 |
| 57 | Lethargy (HP:0001254) | 1.99812001 |
| 58 | Methylmalonic acidemia (HP:0002912) | 1.99064008 |
| 59 | Cerebral hypomyelination (HP:0006808) | 1.98746258 |
| 60 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.98200098 |
| 61 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.98200098 |
| 62 | Exertional dyspnea (HP:0002875) | 1.97660544 |
| 63 | Abnormality of the renal medulla (HP:0100957) | 1.95037624 |
| 64 | CNS demyelination (HP:0007305) | 1.94701087 |
| 65 | Methylmalonic aciduria (HP:0012120) | 1.94419596 |
| 66 | Nephrogenic diabetes insipidus (HP:0009806) | 1.93839408 |
| 67 | Congenital primary aphakia (HP:0007707) | 1.93442981 |
| 68 | Opisthotonus (HP:0002179) | 1.86959755 |
| 69 | Anencephaly (HP:0002323) | 1.86426004 |
| 70 | Poor suck (HP:0002033) | 1.85685517 |
| 71 | Preaxial hand polydactyly (HP:0001177) | 1.84797825 |
| 72 | Hypoplastic pelvis (HP:0008839) | 1.80219251 |
| 73 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.79806092 |
| 74 | Polyphagia (HP:0002591) | 1.79572668 |
| 75 | Delayed CNS myelination (HP:0002188) | 1.79330297 |
| 76 | Birth length less than 3rd percentile (HP:0003561) | 1.79294787 |
| 77 | Increased intramyocellular lipid droplets (HP:0012240) | 1.77394697 |
| 78 | Abnormality of the pons (HP:0007361) | 1.76762357 |
| 79 | Cystic liver disease (HP:0006706) | 1.76594947 |
| 80 | X-linked dominant inheritance (HP:0001423) | 1.75636472 |
| 81 | Thyroid-stimulating hormone excess (HP:0002925) | 1.75284411 |
| 82 | Concave nail (HP:0001598) | 1.75200091 |
| 83 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.74766811 |
| 84 | Type I transferrin isoform profile (HP:0003642) | 1.74392484 |
| 85 | Genital tract atresia (HP:0001827) | 1.74182799 |
| 86 | Optic nerve coloboma (HP:0000588) | 1.74065683 |
| 87 | Shoulder girdle muscle weakness (HP:0003547) | 1.73321862 |
| 88 | Abnormality of the metopic suture (HP:0005556) | 1.72196275 |
| 89 | Vaginal atresia (HP:0000148) | 1.72085622 |
| 90 | Postaxial foot polydactyly (HP:0001830) | 1.71444034 |
| 91 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.70311231 |
| 92 | Respiratory difficulties (HP:0002880) | 1.69355855 |
| 93 | Abnormal biliary tract physiology (HP:0012439) | 1.68970877 |
| 94 | Bile duct proliferation (HP:0001408) | 1.68970877 |
| 95 | Abnormality of serum amino acid levels (HP:0003112) | 1.67127340 |
| 96 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.66145075 |
| 97 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.66145075 |
| 98 | Dandy-Walker malformation (HP:0001305) | 1.65885055 |
| 99 | Microvesicular hepatic steatosis (HP:0001414) | 1.65657171 |
| 100 | Congenital, generalized hypertrichosis (HP:0004540) | 1.65007378 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ZAK | 3.39804700 |
| 2 | VRK2 | 3.31015327 |
| 3 | MAP4K2 | 3.00233500 |
| 4 | BUB1 | 2.90838083 |
| 5 | TRIM28 | 2.62174643 |
| 6 | VRK1 | 2.56542576 |
| 7 | WNK3 | 2.54965049 |
| 8 | CDC7 | 2.45359762 |
| 9 | MAP2K7 | 2.43952481 |
| 10 | SRPK1 | 2.38188346 |
| 11 | MAP3K4 | 2.31668020 |
| 12 | DYRK2 | 2.14110594 |
| 13 | MARK1 | 2.09401190 |
| 14 | NUAK1 | 2.09009516 |
| 15 | TLK1 | 2.06069615 |
| 16 | BCR | 2.03956622 |
| 17 | TSSK6 | 1.94926201 |
| 18 | BCKDK | 1.83238516 |
| 19 | CSNK1G3 | 1.78100173 |
| 20 | NEK1 | 1.71311821 |
| 21 | TAF1 | 1.70409984 |
| 22 | STK16 | 1.67010817 |
| 23 | PLK3 | 1.64316123 |
| 24 | PBK | 1.57389764 |
| 25 | CSNK1G2 | 1.57201655 |
| 26 | CSNK1A1L | 1.54399865 |
| 27 | CASK | 1.53976579 |
| 28 | CSNK1G1 | 1.50921629 |
| 29 | MAPK13 | 1.41972441 |
| 30 | PLK4 | 1.38055046 |
| 31 | DYRK3 | 1.29870916 |
| 32 | WEE1 | 1.25588794 |
| 33 | NME1 | 1.16848028 |
| 34 | ADRBK2 | 1.16596305 |
| 35 | PINK1 | 1.14686451 |
| 36 | WNK4 | 1.11472657 |
| 37 | PLK1 | 1.08934155 |
| 38 | CCNB1 | 1.06930972 |
| 39 | RPS6KA4 | 1.06295296 |
| 40 | GRK1 | 1.05374900 |
| 41 | ATR | 1.05025545 |
| 42 | PNCK | 1.04663731 |
| 43 | MINK1 | 1.00126915 |
| 44 | ERBB3 | 0.99315063 |
| 45 | TTK | 0.97711565 |
| 46 | PDK2 | 0.96623944 |
| 47 | AURKA | 0.95371678 |
| 48 | MKNK1 | 0.94519187 |
| 49 | EPHA4 | 0.94421218 |
| 50 | TNIK | 0.94317199 |
| 51 | RPS6KA5 | 0.94007291 |
| 52 | AURKB | 0.92900407 |
| 53 | PRKCG | 0.90536808 |
| 54 | BRSK2 | 0.89873177 |
| 55 | LIMK1 | 0.89390670 |
| 56 | PLK2 | 0.86671441 |
| 57 | MKNK2 | 0.85983992 |
| 58 | BMPR1B | 0.84561583 |
| 59 | INSRR | 0.80997670 |
| 60 | CHEK2 | 0.80589814 |
| 61 | TIE1 | 0.68456675 |
| 62 | OXSR1 | 0.63814936 |
| 63 | STK39 | 0.62725980 |
| 64 | TESK2 | 0.62648111 |
| 65 | MST4 | 0.60669785 |
| 66 | BRSK1 | 0.59717960 |
| 67 | DAPK1 | 0.58740031 |
| 68 | EIF2AK2 | 0.56809375 |
| 69 | UHMK1 | 0.56325171 |
| 70 | EPHA3 | 0.55565004 |
| 71 | PRKCE | 0.53106975 |
| 72 | PASK | 0.52810002 |
| 73 | NEK2 | 0.51484991 |
| 74 | CSNK1A1 | 0.49322433 |
| 75 | MAP2K4 | 0.48714765 |
| 76 | PAK3 | 0.48421685 |
| 77 | CSNK2A1 | 0.46296398 |
| 78 | CDK14 | 0.45624465 |
| 79 | TESK1 | 0.45088385 |
| 80 | ADRBK1 | 0.45076980 |
| 81 | MAPKAPK5 | 0.44384545 |
| 82 | CDK18 | 0.44129367 |
| 83 | PHKG1 | 0.42214756 |
| 84 | PHKG2 | 0.42214756 |
| 85 | ATM | 0.40331482 |
| 86 | DYRK1A | 0.39164908 |
| 87 | CSNK2A2 | 0.38675000 |
| 88 | CDK15 | 0.38103904 |
| 89 | CHEK1 | 0.37617980 |
| 90 | CDK19 | 0.37204995 |
| 91 | DAPK3 | 0.36873652 |
| 92 | CDK8 | 0.36704881 |
| 93 | DYRK1B | 0.36294898 |
| 94 | EIF2AK1 | 0.36087517 |
| 95 | GRK5 | 0.35971479 |
| 96 | CDK11A | 0.35905480 |
| 97 | PKN1 | 0.35023683 |
| 98 | PAK6 | 0.33402145 |
| 99 | CSNK1E | 0.31330832 |
| 100 | EIF2AK3 | 0.31253285 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.50820506 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.50036376 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.15006110 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 2.57100651 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.56272987 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.50373053 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.36852830 |
| 8 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.35144469 |
| 9 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.33957993 |
| 10 | Huntingtons disease_Homo sapiens_hsa05016 | 2.27945668 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.03807904 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 2.02932179 |
| 13 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.98697147 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 1.97226184 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 1.91931843 |
| 16 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.88813595 |
| 17 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.88583977 |
| 18 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.88192728 |
| 19 | Spliceosome_Homo sapiens_hsa03040 | 1.85642489 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.83463849 |
| 21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.81607506 |
| 22 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.63945306 |
| 23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.63255648 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.58485401 |
| 25 | Sulfur relay system_Homo sapiens_hsa04122 | 1.50905743 |
| 26 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.47329624 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.47083401 |
| 28 | RNA transport_Homo sapiens_hsa03013 | 1.44785986 |
| 29 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.42512131 |
| 30 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.39416118 |
| 31 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.39159055 |
| 32 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.38951581 |
| 33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.33222866 |
| 34 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.32968781 |
| 35 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.31737533 |
| 36 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.27681453 |
| 37 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.24679067 |
| 38 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.24216850 |
| 39 | Nicotine addiction_Homo sapiens_hsa05033 | 1.18701182 |
| 40 | Phototransduction_Homo sapiens_hsa04744 | 1.18371171 |
| 41 | Purine metabolism_Homo sapiens_hsa00230 | 1.17641530 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.16822490 |
| 43 | Alcoholism_Homo sapiens_hsa05034 | 1.14395870 |
| 44 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.14329200 |
| 45 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.13606071 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.12042398 |
| 47 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.04680236 |
| 48 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.99052784 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.98483530 |
| 50 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.94214637 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.91449299 |
| 52 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.91335769 |
| 53 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.89074230 |
| 54 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.88024179 |
| 55 | Carbon metabolism_Homo sapiens_hsa01200 | 0.86014097 |
| 56 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.85062339 |
| 57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.84432225 |
| 58 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.83452020 |
| 59 | Cell cycle_Homo sapiens_hsa04110 | 0.82913018 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.80280144 |
| 61 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.75770104 |
| 62 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.72833881 |
| 63 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.71374761 |
| 64 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.68732732 |
| 65 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.67253234 |
| 66 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.66234012 |
| 67 | GABAergic synapse_Homo sapiens_hsa04727 | 0.63728657 |
| 68 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.63539885 |
| 69 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.62542906 |
| 70 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.62452360 |
| 71 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.55995308 |
| 72 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.55848620 |
| 73 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.55800084 |
| 74 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.55490226 |
| 75 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.53164898 |
| 76 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.50351717 |
| 77 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.49618987 |
| 78 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.48965340 |
| 79 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.48594579 |
| 80 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.46208126 |
| 81 | Morphine addiction_Homo sapiens_hsa05032 | 0.45399840 |
| 82 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.43727956 |
| 83 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.42470900 |
| 84 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.40848094 |
| 85 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.39391067 |
| 86 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.38981523 |
| 87 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.37813227 |
| 88 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.36150633 |
| 89 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.35050853 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.34342095 |
| 91 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.33976354 |
| 92 | Taste transduction_Homo sapiens_hsa04742 | 0.31717043 |
| 93 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.31050970 |
| 94 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.31039204 |
| 95 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.30742440 |
| 96 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.29158529 |
| 97 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.28570317 |
| 98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.27454358 |
| 99 | Cocaine addiction_Homo sapiens_hsa05030 | 0.26910645 |
| 100 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26474507 |

