ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	6.29178791
2	regulation of triglyceride catabolic process (GO:0010896)	5.13090913
3	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	5.02614316
4	DNA deamination (GO:0045006)	4.88628858
5	pyrimidine nucleobase catabolic process (GO:0006208)	4.49783481
6	drug catabolic process (GO:0042737)	4.48090759
7	serine family amino acid catabolic process (GO:0009071)	4.30825956
8	regulation of heterotypic cell-cell adhesion (GO:0034114)	4.29805311
9	exogenous drug catabolic process (GO:0042738)	4.21610457
10	high-density lipoprotein particle remodeling (GO:0034375)	3.95744973
11	proteasome assembly (GO:0043248)	3.93500413
12	regulation of cholesterol esterification (GO:0010872)	3.84141703
13	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.79690030
14	arginine catabolic process (GO:0006527)	3.79368715
15	L-phenylalanine catabolic process (GO:0006559)	3.75317171
16	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.75317171
17	bile acid biosynthetic process (GO:0006699)	3.71822215
18	aldehyde catabolic process (GO:0046185)	3.62205131
19	nucleobase catabolic process (GO:0046113)	3.61413744
20	alkaloid metabolic process (GO:0009820)	3.52953763
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.49291456
22	phospholipid efflux (GO:0033700)	3.49050467
23	cysteine metabolic process (GO:0006534)	3.43793208
24	cullin deneddylation (GO:0010388)	3.41577189
25	nucleoside transmembrane transport (GO:1901642)	3.40597640
26	regulation of lipoprotein particle clearance (GO:0010984)	3.36080856
27	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.34843524
28	aromatic amino acid family catabolic process (GO:0009074)	3.33930508
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.33826808
30	NADH dehydrogenase complex assembly (GO:0010257)	3.33826808
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.33826808
32	cholesterol biosynthetic process (GO:0006695)	3.31457227
33	phospholipid homeostasis (GO:0055091)	3.30764111
34	epoxygenase P450 pathway (GO:0019373)	3.30335759
35	reverse cholesterol transport (GO:0043691)	3.27086469
36	negative regulation of fibrinolysis (GO:0051918)	3.27056763
37	sterol biosynthetic process (GO:0016126)	3.24385151
38	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.23154174
39	ATP synthesis coupled proton transport (GO:0015986)	3.23154174
40	L-phenylalanine metabolic process (GO:0006558)	3.21613911
41	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.21613911
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.20007071
43	otic vesicle formation (GO:0030916)	3.19657062
44	protein deneddylation (GO:0000338)	3.19191441
45	serine family amino acid metabolic process (GO:0009069)	3.17407887
46	hormone catabolic process (GO:0042447)	3.17263826
47	cellular ketone body metabolic process (GO:0046950)	3.16230080
48	S-adenosylmethionine metabolic process (GO:0046500)	3.16224936
49	plasma lipoprotein particle remodeling (GO:0034369)	3.12735135
50	protein-lipid complex remodeling (GO:0034368)	3.12735135
51	macromolecular complex remodeling (GO:0034367)	3.12735135
52	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.10373656
53	heme transport (GO:0015886)	3.08253545
54	regulation of fibrinolysis (GO:0051917)	3.07509044
55	arginine metabolic process (GO:0006525)	3.05648843
56	triglyceride homeostasis (GO:0070328)	3.05091925
57	acylglycerol homeostasis (GO:0055090)	3.05091925
58	L-serine metabolic process (GO:0006563)	3.03009026
59	rRNA modification (GO:0000154)	3.02630056
60	presynaptic membrane assembly (GO:0097105)	3.01643174
61	omega-hydroxylase P450 pathway (GO:0097267)	3.01640123
62	rRNA methylation (GO:0031167)	3.00771525
63	water-soluble vitamin biosynthetic process (GO:0042364)	3.00143904
64	bile acid metabolic process (GO:0008206)	2.98569970
65	indolalkylamine metabolic process (GO:0006586)	2.98390228
66	tryptophan catabolic process (GO:0006569)	2.97142363
67	indole-containing compound catabolic process (GO:0042436)	2.97142363
68	indolalkylamine catabolic process (GO:0046218)	2.97142363
69	auditory behavior (GO:0031223)	2.97048394
70	regulation of cellular amino acid metabolic process (GO:0006521)	2.97020161
71	glycine metabolic process (GO:0006544)	2.94291309
72	negative regulation of sterol transport (GO:0032372)	2.93457637
73	negative regulation of cholesterol transport (GO:0032375)	2.93457637
74	drug metabolic process (GO:0017144)	2.92843135
75	L-methionine biosynthetic process (GO:0071265)	2.90272242
76	amino acid salvage (GO:0043102)	2.90272242
77	L-methionine salvage (GO:0071267)	2.90272242
78	protein carboxylation (GO:0018214)	2.87894802
79	peptidyl-glutamic acid carboxylation (GO:0017187)	2.87894802
80	kynurenine metabolic process (GO:0070189)	2.87352834
81	cellular biogenic amine catabolic process (GO:0042402)	2.87177766
82	amine catabolic process (GO:0009310)	2.87177766
83	phenylpropanoid metabolic process (GO:0009698)	2.86052147
84	ketone body metabolic process (GO:1902224)	2.84900269
85	oxidative demethylation (GO:0070989)	2.83937123
86	respiratory electron transport chain (GO:0022904)	2.83246253
87	negative regulation of lipase activity (GO:0060192)	2.82526861
88	protein complex biogenesis (GO:0070271)	2.81308338
89	plasma lipoprotein particle assembly (GO:0034377)	2.80978346
90	electron transport chain (GO:0022900)	2.79611526
91	intestinal cholesterol absorption (GO:0030299)	2.78175729
92	isoprenoid biosynthetic process (GO:0008299)	2.75936209
93	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74998466
94	oxidative phosphorylation (GO:0006119)	2.74804237
95	regulation of protein activation cascade (GO:2000257)	2.73552422
96	coenzyme catabolic process (GO:0009109)	2.73491893
97	glucuronate metabolic process (GO:0019585)	2.72749595
98	uronic acid metabolic process (GO:0006063)	2.72749595
99	limb bud formation (GO:0060174)	2.71211407
100	proline metabolic process (GO:0006560)	2.70723528

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.89288738
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.62597006
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.50622140
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.38457881
5	VDR_22108803_ChIP-Seq_LS180_Human	3.37351417
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.29416456
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.94906212
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.73369466
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64564360
10	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.61455544
11	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.60618460
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45212961
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.44043438
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38725799
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.37845649
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.36631217
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.27460266
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.25997140
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.18585846
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.16857486
21	IGF1R_20145208_ChIP-Seq_DFB_Human	2.13951816
22	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.09384771
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.05062336
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.04483081
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.86110915
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.82402166
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.78632321
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.74464966
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.68157531
30	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.68086918
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65943285
32	EWS_26573619_Chip-Seq_HEK293_Human	1.64181037
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.61244520
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61231379
35	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.58969889
36	E2F7_22180533_ChIP-Seq_HELA_Human	1.55105857
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50198418
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.49408156
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.47337213
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.46513771
41	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.45986099
42	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.42987891
43	P300_19829295_ChIP-Seq_ESCs_Human	1.42781837
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.41349347
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.36931555
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.36256927
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31827429
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28970150
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.28651917
50	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24401816
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.23822382
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.22948188
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22028250
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21458562
55	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.20665670
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20532582
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17334632
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17334632
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15336053
60	AR_20517297_ChIP-Seq_VCAP_Human	1.10716064
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10024832
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.09597738
63	FUS_26573619_Chip-Seq_HEK293_Human	1.08807891
64	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.06905753
65	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.06149541
66	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.04728715
67	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.04468509
68	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04072503
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03646922
70	BCAT_22108803_ChIP-Seq_LS180_Human	0.99826482
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.99343760
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98408618
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97774936
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97774936
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97626469
76	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97483997
77	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.96955503
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96682358
79	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.96398393
80	CBP_21632823_ChIP-Seq_H3396_Human	0.95569862
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.94458751
82	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93546462
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.91698102
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91696176
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.91310320
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.90577477
87	NCOR_22424771_ChIP-Seq_293T_Human	0.90533307
88	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.90236955
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89944909
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.89240501
91	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.88528734
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.88418835
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88418835
94	TP53_22573176_ChIP-Seq_HFKS_Human	0.88200785
95	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.88119492
96	EZH2_22144423_ChIP-Seq_EOC_Human	0.85737229
97	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.85312262
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85188279
99	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.85181919
100	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.83283597

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	4.86806079
2	MP0002139_abnormal_hepatobiliary_system	4.72631341
3	MP0005085_abnormal_gallbladder_physiolo	3.55760894
4	MP0003011_delayed_dark_adaptation	3.30497035
5	MP0008875_abnormal_xenobiotic_pharmacok	3.21328468
6	MP0005360_urolithiasis	3.02208168
7	MP0000569_abnormal_digit_pigmentation	2.93689300
8	MP0005365_abnormal_bile_salt	2.88931884
9	MP0003195_calcinosis	2.73828821
10	MP0002282_abnormal_trachea_morphology	2.68858671
11	MP0003252_abnormal_bile_duct	2.64686635
12	MP0009840_abnormal_foam_cell	2.63737853
13	MP0005084_abnormal_gallbladder_morpholo	2.54755205
14	MP0010030_abnormal_orbit_morphology	2.46560335
15	MP0005083_abnormal_biliary_tract	2.18760251
16	MP0001485_abnormal_pinna_reflex	2.16848877
17	MP0002102_abnormal_ear_morphology	2.15123105
18	MP0000566_synostosis	2.14861207
19	MP0001986_abnormal_taste_sensitivity	2.14465777
20	MP0003136_yellow_coat_color	2.01969342
21	MP0001984_abnormal_olfaction	1.99926048
22	MP0001529_abnormal_vocalization	1.88349831
23	MP0006054_spinal_hemorrhage	1.83448015
24	MP0004145_abnormal_muscle_electrophysio	1.80010869
25	MP0004270_analgesia	1.74159108
26	MP0010329_abnormal_lipoprotein_level	1.73255121
27	MP0003718_maternal_effect	1.66610034
28	MP0006276_abnormal_autonomic_nervous	1.64247746
29	MP0005645_abnormal_hypothalamus_physiol	1.62552292
30	MP0005248_abnormal_Harderian_gland	1.60844924
31	MP0002876_abnormal_thyroid_physiology	1.58538846
32	MP0006292_abnormal_olfactory_placode	1.49019612
33	MP0000778_abnormal_nervous_system	1.41209608
34	MP0005551_abnormal_eye_electrophysiolog	1.36868081
35	MP0003806_abnormal_nucleotide_metabolis	1.34730057
36	MP0001346_abnormal_lacrimal_gland	1.32523476
37	MP0005332_abnormal_amino_acid	1.32286834
38	MP0004742_abnormal_vestibular_system	1.31841549
39	MP0003868_abnormal_feces_composition	1.30998387
40	MP0005167_abnormal_blood-brain_barrier	1.28033483
41	MP0008872_abnormal_physiological_respon	1.26475182
42	MP0004019_abnormal_vitamin_homeostasis	1.25979530
43	MP0009697_abnormal_copulation	1.25659918
44	MP0001666_abnormal_nutrient_absorption	1.24129699
45	MP0001905_abnormal_dopamine_level	1.20517863
46	MP0003191_abnormal_cellular_cholesterol	1.17832709
47	MP0004142_abnormal_muscle_tone	1.17003077
48	MP0000372_irregular_coat_pigmentation	1.15108098
49	MP0003646_muscle_fatigue	1.13134756
50	MP0002736_abnormal_nociception_after	1.12712574
51	MP0000747_muscle_weakness	1.11929463
52	MP0001764_abnormal_homeostasis	1.11618946
53	MP0001968_abnormal_touch/_nociception	1.02283401
54	MP0006036_abnormal_mitochondrial_physio	0.95665108
55	MP0004885_abnormal_endolymph	0.92397310
56	MP0005636_abnormal_mineral_homeostasis	0.89446927
57	MP0003186_abnormal_redox_activity	0.87464818
58	MP0000613_abnormal_salivary_gland	0.86503596
59	MP0000609_abnormal_liver_physiology	0.85988989
60	MP0005253_abnormal_eye_physiology	0.85599493
61	MP0003638_abnormal_response/metabolism_	0.83309080
62	MP0000749_muscle_degeneration	0.82677470
63	MP0003137_abnormal_impulse_conducting	0.81065231
64	MP0003567_abnormal_fetal_cardiomyocyte	0.79847897
65	MP0005319_abnormal_enzyme/_coenzyme	0.79074984
66	MP0003122_maternal_imprinting	0.78343114
67	MP0001915_intracranial_hemorrhage	0.75997429
68	MP0001286_abnormal_eye_development	0.75604002
69	MP0000647_abnormal_sebaceous_gland	0.75200337
70	MP0001727_abnormal_embryo_implantation	0.70958094
71	MP0003938_abnormal_ear_development	0.70520781
72	MP0003880_abnormal_central_pattern	0.69923896
73	MP0005584_abnormal_enzyme/coenzyme_acti	0.66553153
74	MP0004484_altered_response_of	0.66116447
75	MP0002734_abnormal_mechanical_nocicepti	0.64995698
76	MP0002067_abnormal_sensory_capabilities	0.64786345
77	MP0004215_abnormal_myocardial_fiber	0.64721115
78	MP0003121_genomic_imprinting	0.64650362
79	MP0000534_abnormal_ureter_morphology	0.64527592
80	MP0008775_abnormal_heart_ventricle	0.63671532
81	MP0002332_abnormal_exercise_endurance	0.62163209
82	MP0002118_abnormal_lipid_homeostasis	0.61576475
83	MP0005408_hypopigmentation	0.61356737
84	MP0003959_abnormal_lean_body	0.61022936
85	MP0003786_premature_aging	0.60112557
86	MP0005220_abnormal_exocrine_pancreas	0.59729196
87	MP0001963_abnormal_hearing_physiology	0.59582328
88	MP0006035_abnormal_mitochondrial_morpho	0.58499218
89	MP0005620_abnormal_muscle_contractility	0.58140608
90	MP0005670_abnormal_white_adipose	0.57920470
91	MP0008995_early_reproductive_senescence	0.57801964
92	MP0002751_abnormal_autonomic_nervous	0.57764341
93	MP0002909_abnormal_adrenal_gland	0.57724569
94	MP0002269_muscular_atrophy	0.57024540
95	MP0002752_abnormal_somatic_nervous	0.56415304
96	MP0006072_abnormal_retinal_apoptosis	0.56274983
97	MP0005187_abnormal_penis_morphology	0.54798690
98	MP0005377_hearing/vestibular/ear_phenot	0.54517674
99	MP0003878_abnormal_ear_physiology	0.54517674
100	MP0008058_abnormal_DNA_repair	0.53324541

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased serum pyruvate (HP:0003542)	5.79749469
2	Abnormality of glycolysis (HP:0004366)	5.15168108
3	Abnormality of the labia minora (HP:0012880)	4.36961152
4	Intrahepatic cholestasis (HP:0001406)	4.12429878
5	Acute encephalopathy (HP:0006846)	3.86174180
6	Prolonged partial thromboplastin time (HP:0003645)	3.83487769
7	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.76052933
8	Acute necrotizing encephalopathy (HP:0006965)	3.69906601
9	Spontaneous abortion (HP:0005268)	3.68108417
10	Hypobetalipoproteinemia (HP:0003563)	3.62482426
11	Deep venous thrombosis (HP:0002625)	3.62025948
12	Delayed CNS myelination (HP:0002188)	3.42439386
13	Abnormality of pyrimidine metabolism (HP:0004353)	3.38343428
14	Bilateral microphthalmos (HP:0007633)	3.33500872
15	Hypoalphalipoproteinemia (HP:0003233)	3.23576740
16	Increased CSF lactate (HP:0002490)	3.16831544
17	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.14051103
18	Mitochondrial inheritance (HP:0001427)	3.12852233
19	Reduced antithrombin III activity (HP:0001976)	3.07725329
20	Hypolipoproteinemia (HP:0010981)	3.06878915
21	Abnormal mitochondria in muscle tissue (HP:0008316)	3.06752475
22	Hepatic necrosis (HP:0002605)	3.03390352
23	Hepatocellular necrosis (HP:0001404)	2.99920429
24	Progressive macrocephaly (HP:0004481)	2.96044382
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.90965998
26	Abnormality of alanine metabolism (HP:0010916)	2.90965998
27	Hyperalaninemia (HP:0003348)	2.90965998
28	Cerebral edema (HP:0002181)	2.70162244
29	Bifid tongue (HP:0010297)	2.67080718
30	Anophthalmia (HP:0000528)	2.65609658
31	Hypoplasia of the fovea (HP:0007750)	2.64458220
32	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.64458220
33	Increased serum lactate (HP:0002151)	2.53588155
34	Hypothermia (HP:0002045)	2.52565889
35	Optic disc pallor (HP:0000543)	2.52208484
36	Congenital stationary night blindness (HP:0007642)	2.51331985
37	Amyloidosis (HP:0011034)	2.48402932
38	Abnormal lung lobation (HP:0002101)	2.47124986
39	Bicornuate uterus (HP:0000813)	2.45736364
40	Megalencephaly (HP:0001355)	2.37838483
41	Joint hemorrhage (HP:0005261)	2.33180124
42	Molar tooth sign on MRI (HP:0002419)	2.29555659
43	Abnormality of midbrain morphology (HP:0002418)	2.29555659
44	Inability to walk (HP:0002540)	2.25647727
45	Partial duplication of thumb phalanx (HP:0009944)	2.21514872
46	Type II lissencephaly (HP:0007260)	2.19127369
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18889363
48	Generalized aminoaciduria (HP:0002909)	2.17019412
49	Abnormality of the fovea (HP:0000493)	2.15914156
50	Cholecystitis (HP:0001082)	2.14287062
51	Abnormal gallbladder physiology (HP:0012438)	2.14287062
52	Morphological abnormality of the middle ear (HP:0008609)	2.09999636
53	Retinal dysplasia (HP:0007973)	2.07576510
54	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.05935709
55	Central scotoma (HP:0000603)	2.02534902
56	Stomach cancer (HP:0012126)	2.02213838
57	Abnormal pupillary function (HP:0007686)	2.01493271
58	Lactic acidosis (HP:0003128)	1.98833403
59	Fat malabsorption (HP:0002630)	1.98440265
60	Alacrima (HP:0000522)	1.96728793
61	Opisthotonus (HP:0002179)	1.96497704
62	Abnormality of nucleobase metabolism (HP:0010932)	1.93496819
63	Abnormality of methionine metabolism (HP:0010901)	1.90348997
64	Clitoromegaly (HP:0000057)	1.90261423
65	Vaginal atresia (HP:0000148)	1.90151389
66	Lethargy (HP:0001254)	1.89846659
67	CNS demyelination (HP:0007305)	1.89077129
68	Genital tract atresia (HP:0001827)	1.88405341
69	Absent speech (HP:0001344)	1.86999247
70	Hypoplasia of the pons (HP:0012110)	1.86558168
71	Cortical dysplasia (HP:0002539)	1.83567703
72	Metabolic acidosis (HP:0001942)	1.82953324
73	Abnormality of the pons (HP:0007361)	1.80803558
74	Vacuolated lymphocytes (HP:0001922)	1.80503306
75	Constricted visual fields (HP:0001133)	1.78724197
76	Fair hair (HP:0002286)	1.76350523
77	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.76269984
78	Recurrent corneal erosions (HP:0000495)	1.76125640
79	X-linked dominant inheritance (HP:0001423)	1.76063625
80	Multiple enchondromatosis (HP:0005701)	1.75955744
81	Partial duplication of the phalanx of hand (HP:0009999)	1.75614177
82	Abnormality of serum amino acid levels (HP:0003112)	1.75505317
83	Duplicated collecting system (HP:0000081)	1.75481164
84	Abnormality of the renal collecting system (HP:0004742)	1.75473272
85	Steatorrhea (HP:0002570)	1.75388138
86	Respiratory failure (HP:0002878)	1.74841335
87	Duplication of thumb phalanx (HP:0009942)	1.72058539
88	Breast carcinoma (HP:0003002)	1.71573850
89	Aplasia involving bones of the extremities (HP:0009825)	1.70479467
90	Aplasia involving bones of the upper limbs (HP:0009823)	1.70479467
91	Aplasia of the phalanges of the hand (HP:0009802)	1.70479467
92	Glycosuria (HP:0003076)	1.70350454
93	Abnormality of urine glucose concentration (HP:0011016)	1.70350454
94	Blindness (HP:0000618)	1.70293205
95	Hyperglycinemia (HP:0002154)	1.68902762
96	Absent radius (HP:0003974)	1.68725754
97	Vascular calcification (HP:0004934)	1.67304132
98	Abnormal biliary tract physiology (HP:0012439)	1.66939922
99	Bile duct proliferation (HP:0001408)	1.66939922
100	3-Methylglutaconic aciduria (HP:0003535)	1.66309567

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.09370853
2	MST4	3.55973921
3	PDK2	3.51183050
4	PINK1	2.74767036
5	DAPK2	2.64876279
6	CSNK1G3	2.64547133
7	VRK2	2.64395347
8	CSNK1A1L	2.63706585
9	TSSK6	2.53893832
10	CASK	2.50111862
11	NUAK1	2.36198647
12	CSNK1G2	2.33980988
13	FGFR2	2.26924049
14	DYRK2	2.25360308
15	CSNK1G1	2.17980183
16	BCR	2.16610844
17	EIF2AK3	2.12105764
18	BCKDK	2.11001957
19	SIK2	2.06489524
20	PHKG2	1.96425731
21	PHKG1	1.96425731
22	EIF2AK1	1.76522150
23	TRIM28	1.68992125
24	PIK3CG	1.51661802
25	FRK	1.50411534
26	TESK2	1.47476023
27	IRAK2	1.44602691
28	ZAK	1.32175611
29	LIMK1	1.24600857
30	CCNB1	1.23604947
31	ADRBK2	1.22892820
32	TAF1	1.18559080
33	PLK4	1.17200075
34	PLK3	1.14070870
35	EPHA3	1.12494993
36	MAP2K7	1.09647893
37	EIF2AK2	1.06179485
38	DAPK1	1.05973230
39	WNK4	1.04265495
40	NEK9	1.02926414
41	VRK1	1.02700757
42	STK39	1.02159812
43	SRPK1	0.99854438
44	NEK1	0.98206322
45	OXSR1	0.97384347
46	CAMK1D	0.91933934
47	STK16	0.90293141
48	PLK2	0.90086336
49	RPS6KA4	0.89042226
50	PRKCG	0.86898326
51	CDK19	0.83289529
52	MAPK13	0.82916042
53	MAP4K2	0.82182619
54	BUB1	0.81793718
55	GRK1	0.75646058
56	CAMKK2	0.75155571
57	OBSCN	0.70204249
58	CDK8	0.66683017
59	MARK1	0.62567327
60	CAMK1G	0.61490516
61	TNIK	0.61125554
62	KIT	0.60644660
63	CSNK1A1	0.59453766
64	ABL2	0.58208841
65	FGFR1	0.56657887
66	MINK1	0.56222770
67	TIE1	0.53007714
68	PBK	0.52683547
69	NME1	0.51933047
70	BMPR1B	0.51907222
71	NEK2	0.51037311
72	SIK3	0.49948243
73	TLK1	0.49680463
74	AURKA	0.48718044
75	GSK3A	0.47509421
76	GRK5	0.43084650
77	PRKACA	0.42990781
78	PNCK	0.42984712
79	PIM2	0.42776366
80	PRKACG	0.40937072
81	NTRK2	0.39704848
82	PRKCH	0.38759349
83	ALK	0.38579143
84	CSNK1E	0.36914342
85	ROCK1	0.34451712
86	ERBB2	0.32491360
87	CSNK1D	0.32484045
88	AKT2	0.32344250
89	NME2	0.31771640
90	PTK2B	0.31599118
91	INSRR	0.31370241
92	CSNK2A2	0.30913195
93	PRKG1	0.30531373
94	PAK3	0.29648208
95	IRAK1	0.28813038
96	CSNK2A1	0.28014131
97	PRKCB	0.27935879
98	PRKCA	0.26196598
99	PRKCI	0.25840850
100	CAMK2A	0.23961960

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	2.93839083
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.91319208
3	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.82511234
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.68516083
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.48092684
6	Pyruvate metabolism_Homo sapiens_hsa00620	2.47053688
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.45379444
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.40572655
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32287949
10	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.20408552
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.16636034
12	Parkinsons disease_Homo sapiens_hsa05012	2.02273650
13	Retinol metabolism_Homo sapiens_hsa00830	1.93206375
14	Fatty acid elongation_Homo sapiens_hsa00062	1.92519037
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90323599
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.89501199
17	Complement and coagulation cascades_Homo sapiens_hsa04610	1.86515577
18	Propanoate metabolism_Homo sapiens_hsa00640	1.85546884
19	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.84695737
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.83460097
21	Phenylalanine metabolism_Homo sapiens_hsa00360	1.81011753
22	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.79487350
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.77493379
24	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.75891614
25	Fatty acid degradation_Homo sapiens_hsa00071	1.75574055
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.67175036
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.64688599
28	Fatty acid metabolism_Homo sapiens_hsa01212	1.64375052
29	Peroxisome_Homo sapiens_hsa04146	1.62674686
30	Butanoate metabolism_Homo sapiens_hsa00650	1.61482740
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.57917231
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.56089068
33	Caffeine metabolism_Homo sapiens_hsa00232	1.55216170
34	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.52223706
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.52168266
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.48205486
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.37464835
38	Histidine metabolism_Homo sapiens_hsa00340	1.35305981
39	Alzheimers disease_Homo sapiens_hsa05010	1.31137694
40	Arginine biosynthesis_Homo sapiens_hsa00220	1.27125178
41	Huntingtons disease_Homo sapiens_hsa05016	1.25481124
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.22252680
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.19648699
44	Arginine and proline metabolism_Homo sapiens_hsa00330	1.19294086
45	beta-Alanine metabolism_Homo sapiens_hsa00410	1.18728132
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.18030483
47	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12054088
48	Base excision repair_Homo sapiens_hsa03410	1.08880055
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08242776
50	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.06016451
51	Carbon metabolism_Homo sapiens_hsa01200	1.05767843
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.00283248
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.99035644
54	PPAR signaling pathway_Homo sapiens_hsa03320	0.98490019
55	One carbon pool by folate_Homo sapiens_hsa00670	0.94935959
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94903788
57	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.91312973
58	RNA polymerase_Homo sapiens_hsa03020	0.90426858
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.88867035
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.87929585
61	Metabolic pathways_Homo sapiens_hsa01100	0.82695304
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.81260208
63	Protein export_Homo sapiens_hsa03060	0.81134816
64	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79060803
65	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78650802
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75615943
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.74225412
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73657860
69	Sulfur relay system_Homo sapiens_hsa04122	0.73511831
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70940821
71	Glutathione metabolism_Homo sapiens_hsa00480	0.69933897
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69689849
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67815084
74	Sulfur metabolism_Homo sapiens_hsa00920	0.66950191
75	RNA degradation_Homo sapiens_hsa03018	0.64976282
76	Bile secretion_Homo sapiens_hsa04976	0.64757410
77	Basal transcription factors_Homo sapiens_hsa03022	0.64723627
78	Mismatch repair_Homo sapiens_hsa03430	0.60153959
79	DNA replication_Homo sapiens_hsa03030	0.60097764
80	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55164273
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.54315857
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53994130
83	Serotonergic synapse_Homo sapiens_hsa04726	0.44407371
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43626948
85	Purine metabolism_Homo sapiens_hsa00230	0.42981301
86	RNA transport_Homo sapiens_hsa03013	0.42714996
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41437870
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39845812
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.35572773
90	Homologous recombination_Homo sapiens_hsa03440	0.34648204
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30225259
92	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.29500534
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27201814
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.25255042
95	Spliceosome_Homo sapiens_hsa03040	0.25213315
96	Nitrogen metabolism_Homo sapiens_hsa00910	0.25025794
97	Galactose metabolism_Homo sapiens_hsa00052	0.24616152
98	African trypanosomiasis_Homo sapiens_hsa05143	0.23501995
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.22110899
100	GABAergic synapse_Homo sapiens_hsa04727	0.21966064

TUBBP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »