TUBBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)7.20533644
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.27304003
3viral transcription (GO:0019083)4.94861109
4translational termination (GO:0006415)4.89050001
5ribosomal small subunit assembly (GO:0000028)4.66054776
6ATP synthesis coupled proton transport (GO:0015986)4.58218313
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.58218313
8sequestering of actin monomers (GO:0042989)4.56813252
9hindbrain development (GO:0030902)4.42490538
10chaperone-mediated protein transport (GO:0072321)4.40996812
11cotranslational protein targeting to membrane (GO:0006613)4.24262810
12somite development (GO:0061053)4.23154892
13presynaptic membrane assembly (GO:0097105)4.18837474
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.17309977
15protein targeting to ER (GO:0045047)4.11293106
16translational elongation (GO:0006414)3.94533003
17establishment of protein localization to endoplasmic reticulum (GO:0072599)3.89774426
18negative regulation of inclusion body assembly (GO:0090084)3.87167102
19behavioral response to nicotine (GO:0035095)3.78864909
20cellular protein complex disassembly (GO:0043624)3.77846799
21response to pheromone (GO:0019236)3.77072553
22protein localization to endoplasmic reticulum (GO:0070972)3.76706051
23protein neddylation (GO:0045116)3.74148386
24maturation of SSU-rRNA (GO:0030490)3.67568905
25protein complex biogenesis (GO:0070271)3.64162902
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63808092
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.63808092
28NADH dehydrogenase complex assembly (GO:0010257)3.63808092
29pyrimidine nucleobase catabolic process (GO:0006208)3.62060052
30dopaminergic neuron differentiation (GO:0071542)3.58890459
31opioid receptor signaling pathway (GO:0038003)3.58422311
32limb bud formation (GO:0060174)3.57156949
33neuron cell-cell adhesion (GO:0007158)3.55092406
34gamma-aminobutyric acid transport (GO:0015812)3.51077081
35regulation of mesoderm development (GO:2000380)3.50582118
36viral life cycle (GO:0019058)3.50141750
37otic vesicle formation (GO:0030916)3.48357558
38midbrain development (GO:0030901)3.45699392
39synaptic transmission, cholinergic (GO:0007271)3.45027055
40proteasome assembly (GO:0043248)3.42752313
41protein-cofactor linkage (GO:0018065)3.40275440
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39709802
43protein refolding (GO:0042026)3.37334412
44mitochondrial respiratory chain complex assembly (GO:0033108)3.34894886
45respiratory electron transport chain (GO:0022904)3.33506424
46presynaptic membrane organization (GO:0097090)3.32660313
47translational initiation (GO:0006413)3.31010322
48electron transport chain (GO:0022900)3.25471319
49neuron fate determination (GO:0048664)3.25278182
50postsynaptic membrane organization (GO:0001941)3.20690904
51intracellular protein transmembrane import (GO:0044743)3.19393851
52negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.18855974
53protein complex disassembly (GO:0043241)3.14168934
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14012549
55water-soluble vitamin biosynthetic process (GO:0042364)3.07266722
56macromolecular complex disassembly (GO:0032984)3.06078412
57lateral sprouting from an epithelium (GO:0060601)2.99107767
58kidney morphogenesis (GO:0060993)2.98094649
59positive regulation of gastrulation (GO:2000543)2.93837826
60DNA damage response, detection of DNA damage (GO:0042769)2.93561442
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92703502
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92703502
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91742753
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91469522
65inner mitochondrial membrane organization (GO:0007007)2.89695389
66termination of RNA polymerase III transcription (GO:0006386)2.88143532
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.88143532
68ribosomal small subunit biogenesis (GO:0042274)2.87639543
69DNA deamination (GO:0045006)2.83583967
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82494023
71spinal cord motor neuron differentiation (GO:0021522)2.82272950
72retinal ganglion cell axon guidance (GO:0031290)2.80427137
73cell proliferation in forebrain (GO:0021846)2.79576123
74regulation of feeding behavior (GO:0060259)2.77891768
75vocalization behavior (GO:0071625)2.75149023
76sulfation (GO:0051923)2.73705221
77forebrain neuron differentiation (GO:0021879)2.73656463
78regulation of mesenchymal cell apoptotic process (GO:2001053)2.71708768
79nucleobase catabolic process (GO:0046113)2.70742287
80nuclear-transcribed mRNA catabolic process (GO:0000956)2.68804511
81positive regulation of synapse assembly (GO:0051965)2.66324232
82epithelial cilium movement (GO:0003351)2.65931992
83protein targeting to membrane (GO:0006612)2.65896438
84mRNA catabolic process (GO:0006402)2.64839289
85axonemal dynein complex assembly (GO:0070286)2.64642395
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62018777
87translation (GO:0006412)2.61452159
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.61123452
89negative regulation of astrocyte differentiation (GO:0048712)2.59514675
90hydrogen ion transmembrane transport (GO:1902600)2.58177670
91cell proliferation involved in metanephros development (GO:0072203)2.55215538
92regulation of inclusion body assembly (GO:0090083)2.53939827
93neuronal stem cell maintenance (GO:0097150)2.53511957
94rRNA modification (GO:0000154)2.52193951
95vascular smooth muscle contraction (GO:0014829)2.49919086
96central nervous system projection neuron axonogenesis (GO:0021952)2.48251299
97urinary tract smooth muscle contraction (GO:0014848)2.45242769
98organelle disassembly (GO:1903008)2.44823071
99signal peptide processing (GO:0006465)2.42713404
100negative regulation of glial cell differentiation (GO:0045686)2.38739686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08070721
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.22024856
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.99325486
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92784674
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.86438165
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77277815
7VDR_22108803_ChIP-Seq_LS180_Human2.74027958
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.68845942
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46061316
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.41701904
11FUS_26573619_Chip-Seq_HEK293_Human2.39999841
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35272829
13ZNF274_21170338_ChIP-Seq_K562_Hela2.23846959
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21678675
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20850455
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.06243177
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02710014
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01228111
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.99519123
20EWS_26573619_Chip-Seq_HEK293_Human1.99054464
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95399389
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89133948
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.88947699
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88566489
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85977394
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.82278086
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80098469
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77255162
29ELK1_19687146_ChIP-ChIP_HELA_Human1.76748337
30RNF2_27304074_Chip-Seq_NSC_Mouse1.70462126
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66465011
32P300_19829295_ChIP-Seq_ESCs_Human1.66314033
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64974454
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62488512
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62087878
36GBX2_23144817_ChIP-Seq_PC3_Human1.57589363
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57376755
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.53106061
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46522158
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46522158
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46423505
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44034957
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43088209
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.40130203
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38915432
46TAF15_26573619_Chip-Seq_HEK293_Human1.37313688
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37134693
48MYC_18940864_ChIP-ChIP_HL60_Human1.36591324
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32235224
50AR_21572438_ChIP-Seq_LNCaP_Human1.31801638
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.30133547
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29546475
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29261420
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.27668374
55IRF1_19129219_ChIP-ChIP_H3396_Human1.25912837
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23982537
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22501740
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18883516
59REST_21632747_ChIP-Seq_MESCs_Mouse1.18508120
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18035799
61VDR_23849224_ChIP-Seq_CD4+_Human1.17157122
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15682056
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15682056
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14345407
65IGF1R_20145208_ChIP-Seq_DFB_Human1.14251522
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14048290
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13075171
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12898021
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12124972
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11998197
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.11848516
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11742778
73TTF2_22483619_ChIP-Seq_HELA_Human1.11435515
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.10936632
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10581728
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.10230109
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08200143
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.07915723
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.06520001
80ER_23166858_ChIP-Seq_MCF-7_Human1.06135716
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.05954452
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05843385
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.03939516
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03836113
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03240955
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02508120
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.01492992
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01027036
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00966138
90AR_25329375_ChIP-Seq_VCAP_Human1.00800208
91SMAD4_21799915_ChIP-Seq_A2780_Human0.99977718
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99909770
93BCAT_22108803_ChIP-Seq_LS180_Human0.97786884
94SOX2_19829295_ChIP-Seq_ESCs_Human0.96039736
95NANOG_19829295_ChIP-Seq_ESCs_Human0.96039736
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95063407
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93822693
98SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93317148
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92677126
100HTT_18923047_ChIP-ChIP_STHdh_Human0.92565191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.52242767
2MP0009379_abnormal_foot_pigmentation4.06478155
3MP0003880_abnormal_central_pattern3.24627215
4MP0001529_abnormal_vocalization2.81871763
5MP0006292_abnormal_olfactory_placode2.44453594
6MP0002822_catalepsy2.42795025
7MP0002102_abnormal_ear_morphology2.42782613
8MP0006072_abnormal_retinal_apoptosis2.30101512
9MP0004885_abnormal_endolymph2.26007842
10MP0002736_abnormal_nociception_after2.24317410
11MP0004742_abnormal_vestibular_system2.11232535
12MP0000049_abnormal_middle_ear2.09757884
13MP0005423_abnormal_somatic_nervous2.08415804
14MP0002282_abnormal_trachea_morphology2.07991137
15MP0002277_abnormal_respiratory_mucosa2.06966607
16MP0000778_abnormal_nervous_system2.05228242
17MP0003283_abnormal_digestive_organ2.05114505
18MP0000566_synostosis2.03574102
19MP0000569_abnormal_digit_pigmentation2.01519627
20MP0003011_delayed_dark_adaptation1.98788765
21MP0001485_abnormal_pinna_reflex1.98395617
22MP0005084_abnormal_gallbladder_morpholo1.95165304
23MP0001968_abnormal_touch/_nociception1.87963774
24MP0004142_abnormal_muscle_tone1.80210327
25MP0005253_abnormal_eye_physiology1.73540751
26MP0002653_abnormal_ependyma_morphology1.66790810
27MP0005187_abnormal_penis_morphology1.66625636
28MP0001905_abnormal_dopamine_level1.64503079
29MP0001293_anophthalmia1.60690354
30MP0009745_abnormal_behavioral_response1.55779359
31MP0000026_abnormal_inner_ear1.55203427
32MP0000631_abnormal_neuroendocrine_gland1.54747834
33MP0003938_abnormal_ear_development1.50047473
34MP0003122_maternal_imprinting1.48494680
35MP0002272_abnormal_nervous_system1.43534073
36MP0002938_white_spotting1.40344887
37MP0004133_heterotaxia1.40320666
38MP0003119_abnormal_digestive_system1.37228164
39MP0005646_abnormal_pituitary_gland1.35119470
40MP0003890_abnormal_embryonic-extraembry1.34770624
41MP0003635_abnormal_synaptic_transmissio1.34134548
42MP0002837_dystrophic_cardiac_calcinosis1.32143001
43MP0002572_abnormal_emotion/affect_behav1.30080036
44MP0008058_abnormal_DNA_repair1.29358129
45MP0001440_abnormal_grooming_behavior1.28698433
46MP0002234_abnormal_pharynx_morphology1.28154295
47MP0002735_abnormal_chemical_nociception1.27808409
48MP0001486_abnormal_startle_reflex1.27507777
49MP0002928_abnormal_bile_duct1.26801924
50MP0005551_abnormal_eye_electrophysiolog1.23802460
51MP0002751_abnormal_autonomic_nervous1.22983906
52MP0002249_abnormal_larynx_morphology1.21590682
53MP0003937_abnormal_limbs/digits/tail_de1.19825364
54MP0003646_muscle_fatigue1.19776027
55MP0002734_abnormal_mechanical_nocicepti1.18645740
56MP0003315_abnormal_perineum_morphology1.18645039
57MP0001286_abnormal_eye_development1.16312761
58MP0002557_abnormal_social/conspecific_i1.15163717
59MP0008995_early_reproductive_senescence1.14986118
60MP0002067_abnormal_sensory_capabilities1.14385387
61MP0002064_seizures1.13938783
62MP0002638_abnormal_pupillary_reflex1.12498387
63MP0008877_abnormal_DNA_methylation1.11950567
64MP0005391_vision/eye_phenotype1.11828276
65MP0005645_abnormal_hypothalamus_physiol1.08349790
66MP0003878_abnormal_ear_physiology1.08272536
67MP0005377_hearing/vestibular/ear_phenot1.08272536
68MP0008007_abnormal_cellular_replicative1.05981749
69MP0001963_abnormal_hearing_physiology1.05975606
70MP0002752_abnormal_somatic_nervous1.04598859
71MP0008789_abnormal_olfactory_epithelium1.03856686
72MP0002233_abnormal_nose_morphology1.03832481
73MP0003693_abnormal_embryo_hatching1.03660486
74MP0008872_abnormal_physiological_respon1.00443487
75MP0006276_abnormal_autonomic_nervous1.00343964
76MP0002184_abnormal_innervation0.99218802
77MP0005171_absent_coat_pigmentation0.98548564
78MP0009250_abnormal_appendicular_skeleto0.97001358
79MP0009046_muscle_twitch0.95965003
80MP0003755_abnormal_palate_morphology0.91133643
81MP0001984_abnormal_olfaction0.90583288
82MP0000955_abnormal_spinal_cord0.90521437
83MP0001970_abnormal_pain_threshold0.89495238
84MP0002063_abnormal_learning/memory/cond0.89143848
85MP0000537_abnormal_urethra_morphology0.87206636
86MP0005386_behavior/neurological_phenoty0.85537464
87MP0004924_abnormal_behavior0.85537464
88MP0004145_abnormal_muscle_electrophysio0.85229154
89MP0006035_abnormal_mitochondrial_morpho0.84977630
90MP0005195_abnormal_posterior_eye0.81910448
91MP0000647_abnormal_sebaceous_gland0.81794523
92MP0002733_abnormal_thermal_nociception0.79335575
93MP0002882_abnormal_neuron_morphology0.78476032
94MP0001299_abnormal_eye_distance/0.78412251
95MP0003861_abnormal_nervous_system0.78254989
96MP0003121_genomic_imprinting0.78252289
97MP0002697_abnormal_eye_size0.76924515
98MP0004270_analgesia0.76710587
99MP0009053_abnormal_anal_canal0.75969808
100MP0005448_abnormal_energy_balance0.75841041

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.34514463
2Increased hepatocellular lipid droplets (HP:0006565)4.10023833
3Congenital, generalized hypertrichosis (HP:0004540)4.04303013
4Lipid accumulation in hepatocytes (HP:0006561)3.75555764
5Acute necrotizing encephalopathy (HP:0006965)3.65791106
6Type 2 muscle fiber atrophy (HP:0003554)3.52150839
7Mitochondrial inheritance (HP:0001427)3.47903175
8Renal Fanconi syndrome (HP:0001994)3.43286857
9Reticulocytopenia (HP:0001896)3.36824164
10Exertional dyspnea (HP:0002875)3.28803680
11Limb dystonia (HP:0002451)3.24770742
12Bilateral microphthalmos (HP:0007633)3.19388920
13Progressive macrocephaly (HP:0004481)3.09571648
14Acute encephalopathy (HP:0006846)3.09323180
15Maternal diabetes (HP:0009800)3.08467930
16Abnormal mitochondria in muscle tissue (HP:0008316)3.06473235
17Anophthalmia (HP:0000528)2.94397291
18Muscle fiber atrophy (HP:0100295)2.94080643
19Absent septum pellucidum (HP:0001331)2.91538105
20True hermaphroditism (HP:0010459)2.91511313
21Abnormal number of incisors (HP:0011064)2.90727820
22Increased CSF lactate (HP:0002490)2.89255046
23Abnormal number of erythroid precursors (HP:0012131)2.88697546
24Macrocytic anemia (HP:0001972)2.86279639
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.85219738
26Hepatocellular necrosis (HP:0001404)2.82353733
27Abnormality of cells of the erythroid lineage (HP:0012130)2.69102731
28Colon cancer (HP:0003003)2.68950401
29Poor suck (HP:0002033)2.63715176
3011 pairs of ribs (HP:0000878)2.62863929
31Abnormal respiratory motile cilium physiology (HP:0012261)2.60403363
32Optic nerve hypoplasia (HP:0000609)2.59073162
33Abnormality of the labia minora (HP:0012880)2.57907305
34Optic disc pallor (HP:0000543)2.56458090
35Methylmalonic acidemia (HP:0002912)2.53631667
36Pancreatic cysts (HP:0001737)2.52667150
37Rhinitis (HP:0012384)2.51081727
38Hepatic necrosis (HP:0002605)2.46036949
39Gait imbalance (HP:0002141)2.44805468
40Abnormality of the septum pellucidum (HP:0007375)2.40899923
41Abnormality of renal resorption (HP:0011038)2.40844103
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36303827
43Pancreatic fibrosis (HP:0100732)2.35293024
44Humeroradial synostosis (HP:0003041)2.32749221
45Synostosis involving the elbow (HP:0003938)2.32749221
46Esophageal atresia (HP:0002032)2.32332622
47Progressive cerebellar ataxia (HP:0002073)2.31059179
48Missing ribs (HP:0000921)2.25402278
49Methylmalonic aciduria (HP:0012120)2.23894983
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22102578
51Tubulointerstitial fibrosis (HP:0005576)2.18214267
52Sclerocornea (HP:0000647)2.17975672
53Median cleft lip (HP:0000161)2.16472160
54Hyperglycinemia (HP:0002154)2.15221971
55Medial flaring of the eyebrow (HP:0010747)2.13547680
56Abnormal ciliary motility (HP:0012262)2.09698627
57Respiratory difficulties (HP:0002880)2.08401509
58Tubulointerstitial abnormality (HP:0001969)2.06654426
59Fibular hypoplasia (HP:0003038)2.03715755
60Neuroendocrine neoplasm (HP:0100634)2.03329910
61Hypogonadotrophic hypogonadism (HP:0000044)2.02392992
62Concave nail (HP:0001598)1.98722139
63Increased intramyocellular lipid droplets (HP:0012240)1.98270719
64Cerebral edema (HP:0002181)1.97307021
65Leukodystrophy (HP:0002415)1.96690310
66Abnormality of the neuromuscular junction (HP:0003398)1.94627128
67Fatigable weakness (HP:0003473)1.94627128
68Short 4th metacarpal (HP:0010044)1.94460868
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94460868
703-Methylglutaconic aciduria (HP:0003535)1.93242149
71Specific learning disability (HP:0001328)1.91162686
72Abnormality of midbrain morphology (HP:0002418)1.91099483
73Molar tooth sign on MRI (HP:0002419)1.91099483
74Gastrointestinal atresia (HP:0002589)1.88111120
75Aplasia/Hypoplasia of the fibula (HP:0006492)1.88014609
76Large for gestational age (HP:0001520)1.87278500
77Congenital primary aphakia (HP:0007707)1.86058527
78Vaginal atresia (HP:0000148)1.84914948
79Short tibia (HP:0005736)1.84223190
80Abnormal respiratory epithelium morphology (HP:0012253)1.84110632
81Abnormal respiratory motile cilium morphology (HP:0005938)1.84110632
82Polyphagia (HP:0002591)1.81024759
83Pheochromocytoma (HP:0002666)1.80991452
84Genital tract atresia (HP:0001827)1.80191597
85Aplasia/Hypoplasia of the sternum (HP:0006714)1.80019836
86Abnormality of the renal cortex (HP:0011035)1.79066036
87Morphological abnormality of the middle ear (HP:0008609)1.77175416
88Hyperphosphaturia (HP:0003109)1.77036825
89Congenital stationary night blindness (HP:0007642)1.76906034
90Pallor (HP:0000980)1.76320103
91Meningioma (HP:0002858)1.75451027
92Hemivertebrae (HP:0002937)1.74018987
93Pendular nystagmus (HP:0012043)1.72695219
94Decreased muscle mass (HP:0003199)1.71492209
95Tubular atrophy (HP:0000092)1.69798763
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.69297128
97Myokymia (HP:0002411)1.68596635
98Vertebral hypoplasia (HP:0008417)1.68432194
99Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.68432194
100Nephronophthisis (HP:0000090)1.66972370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.34342847
2PNCK4.76672881
3MAPK154.30595762
4TAF13.72173273
5CASK3.32372700
6VRK23.16749909
7WEE12.99787751
8VRK12.96877742
9MARK12.81030330
10DYRK22.72411608
11WNK32.61757117
12TNIK2.30776539
13MAPK131.97225418
14MKNK21.83218838
15NME11.75780251
16EPHB21.69028095
17NUAK11.50047339
18BUB11.49039771
19ZAK1.39136553
20PLK31.38666921
21DYRK31.30706027
22PINK11.27455934
23MKNK11.21606246
24GRK11.21436985
25IRAK11.18795080
26BMPR1B1.13222772
27NTRK21.11026821
28MAP4K21.08969093
29PLK41.08922820
30PASK1.06384195
31CDC71.05910094
32MAP2K71.05582864
33MAP3K41.02915698
34PRKCG1.02681520
35SRPK10.99191620
36MAP3K100.97305404
37PHKG10.96166523
38PHKG20.96166523
39ERBB30.95592987
40CDK190.94584060
41EIF2AK20.91394683
42GRK50.90488988
43TLK10.89815405
44TIE10.88195659
45MAPKAPK50.85569148
46ADRBK20.84257112
47CDK30.80375782
48STK38L0.77331306
49OXSR10.73210256
50INSRR0.72284273
51CSNK1G20.71889040
52BCR0.70776052
53TRIM280.69553898
54PLK20.66327500
55DYRK1A0.65861818
56TGFBR10.63828356
57GRK70.63282439
58PRKCE0.61271128
59FRK0.59938456
60MAP2K20.56828869
61ADRBK10.52769512
62MINK10.50273729
63STK160.49244679
64UHMK10.46955998
65CHEK20.46784833
66CSNK1G10.45747823
67CSNK1G30.44587635
68BRD40.42689952
69PLK10.42550134
70WNK40.42188572
71NEK10.41517579
72PKN10.40727742
73AURKA0.40331387
74STK390.38494625
75EPHA30.38483387
76MST40.37486039
77NTRK30.37333314
78RPS6KA50.35102579
79ERBB40.34825884
80DAPK30.33179667
81STK40.29078792
82ABL20.28700986
83CLK10.27135780
84TYRO30.26449437
85NLK0.26259105
86CSNK1E0.25291124
87CSNK1A1L0.24508277
88AURKB0.24449929
89TTK0.24097398
90PRKACA0.23771142
91PRKCZ0.23723529
92GSK3A0.23666928
93SIK20.23101860
94CSNK2A10.23064819
95CSNK2A20.21147837
96CSNK1A10.19419024
97CDK50.18776784
98SGK4940.18124195
99SGK2230.18124195
100CDK140.17776747

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.81222749
2Oxidative phosphorylation_Homo sapiens_hsa001904.22563537
3Parkinsons disease_Homo sapiens_hsa050123.87367706
4Protein export_Homo sapiens_hsa030603.35412236
5Proteasome_Homo sapiens_hsa030502.85250828
6Huntingtons disease_Homo sapiens_hsa050162.69789349
7Alzheimers disease_Homo sapiens_hsa050102.48762634
8RNA polymerase_Homo sapiens_hsa030202.45757561
9Cardiac muscle contraction_Homo sapiens_hsa042602.45454169
10Nicotine addiction_Homo sapiens_hsa050332.39240854
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06676597
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.02580965
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94636391
14Spliceosome_Homo sapiens_hsa030401.93388939
15Homologous recombination_Homo sapiens_hsa034401.83673101
16RNA degradation_Homo sapiens_hsa030181.61438068
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.58340280
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56604712
19Mismatch repair_Homo sapiens_hsa034301.53882441
20Basal cell carcinoma_Homo sapiens_hsa052171.43721841
21Steroid biosynthesis_Homo sapiens_hsa001001.43641563
22Phototransduction_Homo sapiens_hsa047441.33161561
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31935123
24GABAergic synapse_Homo sapiens_hsa047271.29809734
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29407373
26Nitrogen metabolism_Homo sapiens_hsa009101.29087286
27One carbon pool by folate_Homo sapiens_hsa006701.27066063
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24320679
29Taste transduction_Homo sapiens_hsa047421.22742477
30Butanoate metabolism_Homo sapiens_hsa006501.19990557
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14789869
32Hedgehog signaling pathway_Homo sapiens_hsa043401.14602043
33Basal transcription factors_Homo sapiens_hsa030221.12505270
34Propanoate metabolism_Homo sapiens_hsa006401.05906239
35Fanconi anemia pathway_Homo sapiens_hsa034601.02144108
36Cocaine addiction_Homo sapiens_hsa050300.98978886
37Glutamatergic synapse_Homo sapiens_hsa047240.98885058
38Morphine addiction_Homo sapiens_hsa050320.94169283
39Systemic lupus erythematosus_Homo sapiens_hsa053220.91063563
40Fatty acid elongation_Homo sapiens_hsa000620.90615721
41Olfactory transduction_Homo sapiens_hsa047400.90461816
42RNA transport_Homo sapiens_hsa030130.86776252
43Pyrimidine metabolism_Homo sapiens_hsa002400.86699294
44Purine metabolism_Homo sapiens_hsa002300.85282967
45Nucleotide excision repair_Homo sapiens_hsa034200.84655027
46Linoleic acid metabolism_Homo sapiens_hsa005910.83374983
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78791497
48Selenocompound metabolism_Homo sapiens_hsa004500.74805950
49Alcoholism_Homo sapiens_hsa050340.74069436
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73946133
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73378058
52beta-Alanine metabolism_Homo sapiens_hsa004100.72281679
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72165274
54Amphetamine addiction_Homo sapiens_hsa050310.67282577
55DNA replication_Homo sapiens_hsa030300.66050215
56Wnt signaling pathway_Homo sapiens_hsa043100.65739313
57Vitamin digestion and absorption_Homo sapiens_hsa049770.62335174
58Non-homologous end-joining_Homo sapiens_hsa034500.59313844
59Peroxisome_Homo sapiens_hsa041460.57946481
60Hippo signaling pathway_Homo sapiens_hsa043900.57668349
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57001316
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56306911
63p53 signaling pathway_Homo sapiens_hsa041150.54422035
64Collecting duct acid secretion_Homo sapiens_hsa049660.53825330
65Serotonergic synapse_Homo sapiens_hsa047260.53483624
66Metabolic pathways_Homo sapiens_hsa011000.53403827
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52271157
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.51031633
69Axon guidance_Homo sapiens_hsa043600.49860020
70Circadian entrainment_Homo sapiens_hsa047130.45951283
71Caffeine metabolism_Homo sapiens_hsa002320.45034162
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.44441121
73TGF-beta signaling pathway_Homo sapiens_hsa043500.43500954
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.41670648
75Dopaminergic synapse_Homo sapiens_hsa047280.41286346
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38448948
77Retinol metabolism_Homo sapiens_hsa008300.38410165
78Insulin secretion_Homo sapiens_hsa049110.38230456
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38107651
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37054580
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36223978
82Asthma_Homo sapiens_hsa053100.35240001
83Ether lipid metabolism_Homo sapiens_hsa005650.34868693
84Folate biosynthesis_Homo sapiens_hsa007900.33822553
85Tyrosine metabolism_Homo sapiens_hsa003500.33564374
86Cholinergic synapse_Homo sapiens_hsa047250.33499890
87Glutathione metabolism_Homo sapiens_hsa004800.33120503
88Antigen processing and presentation_Homo sapiens_hsa046120.32687649
89Regulation of autophagy_Homo sapiens_hsa041400.32415063
90Legionellosis_Homo sapiens_hsa051340.31727969
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31283437
92Base excision repair_Homo sapiens_hsa034100.30769234
93Chemical carcinogenesis_Homo sapiens_hsa052040.30753973
94Fatty acid biosynthesis_Homo sapiens_hsa000610.30121550
95Oocyte meiosis_Homo sapiens_hsa041140.29833295
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29666510
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29557107
98Tryptophan metabolism_Homo sapiens_hsa003800.28317004
99Cell cycle_Homo sapiens_hsa041100.28075712
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27767314

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