ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	8.50895515
2	piRNA metabolic process (GO:0034587)	8.14644475
3	meiotic cell cycle (GO:0051321)	8.03419865
4	oocyte development (GO:0048599)	7.86948395
5	protein kinase C signaling (GO:0070528)	7.19628705
6	positive regulation of histone H3-K4 methylation (GO:0051571)	6.61550599
7	regulation of meiosis I (GO:0060631)	6.58967789
8	positive regulation of humoral immune response (GO:0002922)	6.55271998
9	negative regulation of reproductive process (GO:2000242)	6.50590946
10	DNA methylation involved in gamete generation (GO:0043046)	6.38809031
11	retinal cone cell development (GO:0046549)	6.35859418
12	regulation of histone H3-K9 methylation (GO:0051570)	6.33449906
13	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.27593112
14	female gamete generation (GO:0007292)	6.16573248
15	mitotic chromosome condensation (GO:0007076)	6.00733819
16	reproduction (GO:0000003)	5.68669532
17	regulation of steroid hormone secretion (GO:2000831)	5.28820998
18	negative regulation of histone methylation (GO:0031061)	5.28586862
19	glycine transport (GO:0015816)	5.22174373
20	binding of sperm to zona pellucida (GO:0007339)	5.20208629
21	attachment of spindle microtubules to kinetochore (GO:0008608)	4.97918635
22	protein localization to chromosome, centromeric region (GO:0071459)	4.95877959
23	gene silencing by RNA (GO:0031047)	4.85395494
24	protein localization to kinetochore (GO:0034501)	4.82369366
25	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.68650405
26	regulation of cell maturation (GO:1903429)	4.59513957
27	citrulline biosynthetic process (GO:0019240)	4.48999219
28	positive regulation of reproductive process (GO:2000243)	4.48925831
29	mitotic metaphase plate congression (GO:0007080)	4.42903064
30	fertilization (GO:0009566)	4.35682765
31	single fertilization (GO:0007338)	4.26946274
32	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.16327906
33	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.16327906
34	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.16327906
35	positive regulation of chromosome segregation (GO:0051984)	4.13715371
36	synapsis (GO:0007129)	4.11344235
37	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.07593169
38	sperm-egg recognition (GO:0035036)	4.04001600
39	positive regulation of histone methylation (GO:0031062)	4.03607668
40	regulation of histone H3-K4 methylation (GO:0051569)	4.00917159
41	regulation of steroid hormone biosynthetic process (GO:0090030)	3.96078258
42	positive regulation of gastrulation (GO:2000543)	3.94810160
43	regulation of spindle organization (GO:0090224)	3.90222283
44	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.86230915
45	centriole replication (GO:0007099)	3.78842380
46	chromatin assembly (GO:0031497)	3.78448227
47	L-amino acid import (GO:0043092)	3.77690494
48	regulation of meiosis (GO:0040020)	3.77284927
49	DNA methylation (GO:0006306)	3.76487792
50	DNA alkylation (GO:0006305)	3.76487792
51	CENP-A containing nucleosome assembly (GO:0034080)	3.76324648
52	establishment of chromosome localization (GO:0051303)	3.76257806
53	regulation of reproductive process (GO:2000241)	3.74145816
54	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.69020096
55	regulation of histone methylation (GO:0031060)	3.65851668
56	primitive streak formation (GO:0090009)	3.65475397
57	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.63667414
58	phosphorelay signal transduction system (GO:0000160)	3.61267982
59	DNA replication checkpoint (GO:0000076)	3.58323466
60	metaphase plate congression (GO:0051310)	3.51843238
61	stress granule assembly (GO:0034063)	3.47841052
62	N-terminal protein amino acid acetylation (GO:0006474)	3.46881146
63	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.45959046
64	chromatin remodeling at centromere (GO:0031055)	3.45780640
65	male meiosis I (GO:0007141)	3.45342332
66	gene silencing (GO:0016458)	3.43289400
67	DNA replication-dependent nucleosome assembly (GO:0006335)	3.42370782
68	DNA replication-dependent nucleosome organization (GO:0034723)	3.42370782
69	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.40528325
70	regulation of hypersensitivity (GO:0002883)	3.39243570
71	protein localization to chromosome (GO:0034502)	3.34275459
72	synaptonemal complex assembly (GO:0007130)	3.29684460
73	oogenesis (GO:0048477)	3.27477399
74	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.27050816
75	regulation of phospholipid biosynthetic process (GO:0071071)	3.25830383
76	chromosome organization involved in meiosis (GO:0070192)	3.25065561
77	translesion synthesis (GO:0019985)	3.24267886
78	hyperosmotic salinity response (GO:0042538)	3.24145366
79	cell-cell recognition (GO:0009988)	3.20310723
80	negative regulation of hormone biosynthetic process (GO:0032353)	3.20177722
81	chromatin assembly or disassembly (GO:0006333)	3.16381629
82	regulation of RNA export from nucleus (GO:0046831)	3.15188039
83	regulation of chromatin silencing (GO:0031935)	3.13234208
84	regulation of meiotic cell cycle (GO:0051445)	3.12692907
85	type B pancreatic cell development (GO:0003323)	3.11936856
86	male meiosis (GO:0007140)	3.10649775
87	negative regulation of hormone metabolic process (GO:0032351)	3.10043795
88	negative regulation of histone modification (GO:0031057)	3.09375001
89	positive regulation of hormone biosynthetic process (GO:0046886)	3.08988879
90	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.07862864
91	regulation of corticosteroid hormone secretion (GO:2000846)	3.04580719
92	interkinetic nuclear migration (GO:0022027)	3.04462165
93	regulation of spindle checkpoint (GO:0090231)	3.04402386
94	negative regulation of execution phase of apoptosis (GO:1900118)	3.03965983
95	regulation of cell cycle G2/M phase transition (GO:1902749)	3.03871311
96	meiotic nuclear division (GO:0007126)	3.02006938
97	regulation of chromatin binding (GO:0035561)	3.01432417
98	regulation of acrosome reaction (GO:0060046)	10.9154744
99	regulation of female gonad development (GO:2000194)	10.6570277
100	regulation of DNA methylation (GO:0044030)	10.5398672

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.87150441
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.98309834
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.20920131
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.12167530
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.09796039
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.09796039
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.09796039
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.98261519
9	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.92964481
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.59954706
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.53208049
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.38003591
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.17081919
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.07178213
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04584619
16	EZH2_22144423_ChIP-Seq_EOC_Human	16.5024957
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.93912265
18	AR_21909140_ChIP-Seq_LNCAP_Human	1.93908019
19	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.90253784
20	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.86638463
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.78403584
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52603358
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.41952526
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39408513
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.34305730
26	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33105188
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32452462
28	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.28703855
29	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.26109274
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.21769576
31	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.20510506
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15805923
33	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.02719401
34	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02662426
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02560963
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01257549
37	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00834313
38	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.98749930
39	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.96787951
40	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.94865268
41	CBP_20019798_ChIP-Seq_JUKART_Human	0.93581855
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93581855
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.92979315
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91830829
45	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89155001
46	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.88362657
47	TCF4_23295773_ChIP-Seq_U87_Human	0.88275092
48	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86836413
49	GF1_26923725_Chip-Seq_HPCs_Mouse	0.86497169
50	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.85626046
51	FOXP3_21729870_ChIP-Seq_TREG_Human	0.84336727
52	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.83989857
53	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.83612178
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.83016046
55	RUNX2_22187159_ChIP-Seq_PCA_Human	0.82896881
56	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.81668292
57	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.80964093
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.79681016
59	IRF1_19129219_ChIP-ChIP_H3396_Human	0.77695221
60	AR_25329375_ChIP-Seq_VCAP_Human	0.77053454
61	KLF4_19829295_ChIP-Seq_ESCs_Human	0.76620476
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.75733034
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.75733034
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.75682683
65	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.75227469
66	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.73980299
67	CBP_21632823_ChIP-Seq_H3396_Human	0.73107463
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.73098358
69	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.73072890
70	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.72799975
71	ZNF274_21170338_ChIP-Seq_K562_Hela	0.72240182
72	MYC_18940864_ChIP-ChIP_HL60_Human	0.70387754
73	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.67682477
74	SMAD4_21799915_ChIP-Seq_A2780_Human	0.66534393
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.66045905
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.65338626
77	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.65226991
78	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.64065886
79	HTT_18923047_ChIP-ChIP_STHdh_Human	0.63769936
80	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.63378755
81	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.62921977
82	TP53_22573176_ChIP-Seq_HFKS_Human	0.61430202
83	SMRT_27268052_Chip-Seq_Bcells_Human	0.60536888
84	OCT4_19829295_ChIP-Seq_ESCs_Human	0.59901469
85	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.59645482
86	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.59279792
87	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.59124959
88	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.58718802
89	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.58249681
90	STAT3_23295773_ChIP-Seq_U87_Human	0.57612605
91	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.56617314
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.56538957
93	AHR_22903824_ChIP-Seq_MCF-7_Human	0.56128895
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.55535003
95	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.54510373
96	EWS_26573619_Chip-Seq_HEK293_Human	0.54363792
97	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.54284545
98	DROSHA_22980978_ChIP-Seq_HELA_Human	0.53508012
99	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.51735045
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.50531802

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.56613383
2	MP0006292_abnormal_olfactory_placode	4.16579772
3	MP0008877_abnormal_DNA_methylation	3.80870823
4	MP0005395_other_phenotype	3.49757525
5	MP0008789_abnormal_olfactory_epithelium	3.45740490
6	MP0008057_abnormal_DNA_replication	3.39167334
7	MP0003693_abnormal_embryo_hatching	3.29301319
8	MP0005499_abnormal_olfactory_system	3.17208586
9	MP0005394_taste/olfaction_phenotype	3.17208586
10	MP0003890_abnormal_embryonic-extraembry	2.91714032
11	MP0002139_abnormal_hepatobiliary_system	2.88827339
12	MP0003699_abnormal_female_reproductive	2.65656469
13	MP0010234_abnormal_vibrissa_follicle	2.60620801
14	MP0005360_urolithiasis	2.45927449
15	MP0001929_abnormal_gametogenesis	2.45274665
16	MP0003879_abnormal_hair_cell	2.39300885
17	MP0010030_abnormal_orbit_morphology	2.38359424
18	MP0002138_abnormal_hepatobiliary_system	2.31682727
19	MP0003077_abnormal_cell_cycle	2.26687901
20	MP0008058_abnormal_DNA_repair	2.21235763
21	MP0002210_abnormal_sex_determination	2.16461582
22	MP0010094_abnormal_chromosome_stability	2.10487582
23	MP0000566_synostosis	2.06556094
24	MP0003111_abnormal_nucleus_morphology	2.00467689
25	MP0002234_abnormal_pharynx_morphology	1.95063907
26	MP0003183_abnormal_peptide_metabolism	1.88140902
27	MP0003950_abnormal_plasma_membrane	1.84532948
28	MP0000653_abnormal_sex_gland	1.80914532
29	MP0002161_abnormal_fertility/fecundity	1.76740190
30	MP0001730_embryonic_growth_arrest	1.68731914
31	MP0010368_abnormal_lymphatic_system	1.67056120
32	MP0008932_abnormal_embryonic_tissue	1.59052175
33	MP0010307_abnormal_tumor_latency	1.54202440
34	MP0009840_abnormal_foam_cell	1.53875268
35	MP0001119_abnormal_female_reproductive	1.52601432
36	MP0005410_abnormal_fertilization	1.51486493
37	MP0002160_abnormal_reproductive_system	1.42550199
38	MP0001293_anophthalmia	1.33659962
39	MP0003121_genomic_imprinting	1.33105128
40	MP0000631_abnormal_neuroendocrine_gland	1.32654252
41	MP0001145_abnormal_male_reproductive	1.32597312
42	MP0005646_abnormal_pituitary_gland	1.30156689
43	MP0005389_reproductive_system_phenotype	1.22487498
44	MP0000762_abnormal_tongue_morphology	1.20912155
45	MP0001672_abnormal_embryogenesis/_devel	1.20329260
46	MP0005380_embryogenesis_phenotype	1.20329260
47	MP0009379_abnormal_foot_pigmentation	1.19571114
48	MP0003698_abnormal_male_reproductive	1.13977808
49	MP0002233_abnormal_nose_morphology	1.12824745
50	MP0004957_abnormal_blastocyst_morpholog	1.12311036
51	MP0005647_abnormal_sex_gland	1.08075992
52	MP0000678_abnormal_parathyroid_gland	1.04914017
53	MP0000350_abnormal_cell_proliferation	1.04607834
54	MP0003136_yellow_coat_color	1.00773131
55	MP0003252_abnormal_bile_duct	1.00138322
56	MP0010678_abnormal_skin_adnexa	0.98874600
57	MP0003119_abnormal_digestive_system	0.94688413
58	MP0001664_abnormal_digestion	0.93705232
59	MP0004142_abnormal_muscle_tone	0.91690380
60	MP0000427_abnormal_hair_cycle	0.90418272
61	MP0001986_abnormal_taste_sensitivity	0.90089913
62	MP0003941_abnormal_skin_development	0.89000624
63	MP0000049_abnormal_middle_ear	0.84918125
64	MP0005085_abnormal_gallbladder_physiolo	0.82647936
65	MP0002272_abnormal_nervous_system	0.81498301
66	MP0002796_impaired_skin_barrier	0.81041202
67	MP0001666_abnormal_nutrient_absorption	0.80428317
68	MP0002084_abnormal_developmental_patter	0.77236315
69	MP0006276_abnormal_autonomic_nervous	0.76828046
70	MP0005501_abnormal_skin_physiology	0.75783406
71	MP0001919_abnormal_reproductive_system	0.70029026
72	MP0005551_abnormal_eye_electrophysiolog	0.69673803
73	MP0002089_abnormal_postnatal_growth/wei	0.69579532
74	MP0001984_abnormal_olfaction	0.69092475
75	MP0001324_abnormal_eye_pigmentation	0.67020562
76	MP0002085_abnormal_embryonic_tissue	0.64287885
77	MP0005076_abnormal_cell_differentiation	0.60095410
78	MP0001697_abnormal_embryo_size	0.58543536
79	MP0005409_darkened_coat_color	0.57945045
80	MP0003868_abnormal_feces_composition	0.55836119
81	MP0001963_abnormal_hearing_physiology	0.55214817
82	MP0000015_abnormal_ear_pigmentation	0.55094850
83	MP0003984_embryonic_growth_retardation	0.54603090
84	MP0002127_abnormal_cardiovascular_syste	0.53961619
85	MP0002088_abnormal_embryonic_growth/wei	0.50785043
86	MP0001502_abnormal_circadian_rhythm	0.50701794
87	MP0005319_abnormal_enzyme/_coenzyme	0.50423999
88	MP0002098_abnormal_vibrissa_morphology	0.49143225
89	MP0000313_abnormal_cell_death	0.47897952
90	MP0003935_abnormal_craniofacial_develop	0.47876165
91	MP0003959_abnormal_lean_body	0.47145576
92	MP0001881_abnormal_mammary_gland	0.46967567
93	MP0000733_abnormal_muscle_development	0.45427332
94	MP0000383_abnormal_hair_follicle	0.44560312
95	MP0003755_abnormal_palate_morphology	0.42777927
96	MP0002873_normal_phenotype	0.42743308
97	MP0002080_prenatal_lethality	0.42386050
98	MP0002169_no_abnormal_phenotype	0.42255533
99	MP0003861_abnormal_nervous_system	0.41137577
100	MP0005075_abnormal_melanosome_morpholog	0.40629616

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	5.79936762
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.45943448
3	Osteomalacia (HP:0002749)	5.23105546
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.09860895
5	Hypoplasia of the fovea (HP:0007750)	5.09860895
6	Lip pit (HP:0100267)	5.01145509
7	Anterior segment dysgenesis (HP:0007700)	4.93819001
8	Impulsivity (HP:0100710)	4.83717623
9	Abdominal situs inversus (HP:0003363)	4.83007250
10	Abnormality of abdominal situs (HP:0011620)	4.83007250
11	Infertility (HP:0000789)	4.43716689
12	Hypophosphatemic rickets (HP:0004912)	4.42179743
13	Abnormal gallbladder physiology (HP:0012438)	4.37479711
14	Cholecystitis (HP:0001082)	4.37479711
15	Supernumerary spleens (HP:0009799)	4.26004858
16	Abnormality of the fovea (HP:0000493)	4.25476919
17	Papillary thyroid carcinoma (HP:0002895)	4.23135415
18	Facial hemangioma (HP:0000329)	4.15625738
19	Premature ovarian failure (HP:0008209)	3.68467011
20	Chromsome breakage (HP:0040012)	3.58223574
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.55903267
22	Azoospermia (HP:0000027)	3.51632354
23	Septo-optic dysplasia (HP:0100842)	3.40995796
24	Hypokinesia (HP:0002375)	3.38582735
25	Apathy (HP:0000741)	3.33910058
26	Aplasia/Hypoplasia of the macula (HP:0008059)	3.33342967
27	Diminished motivation (HP:0000745)	3.26488260
28	Malnutrition (HP:0004395)	3.24033700
29	Median cleft lip (HP:0000161)	3.20318770
30	Oligodactyly (hands) (HP:0001180)	3.09697566
31	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.04495422
32	Gonadotropin excess (HP:0000837)	2.93594341
33	Spinal cord compression (HP:0002176)	2.93502514
34	Aplasia of the musculature (HP:0100854)	2.90453445
35	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.90129189
36	Urethral obstruction (HP:0000796)	2.88028835
37	Capillary hemangiomas (HP:0005306)	2.87656973
38	Generalized aminoaciduria (HP:0002909)	2.69209735
39	Proximal tubulopathy (HP:0000114)	2.68502073
40	Skin pits (HP:0100276)	2.67822622
41	Absent septum pellucidum (HP:0001331)	2.66536706
42	Abnormal spermatogenesis (HP:0008669)	2.66200799
43	Metaphyseal irregularity (HP:0003025)	2.59346001
44	Abnormal ciliary motility (HP:0012262)	2.56624682
45	Truncal obesity (HP:0001956)	2.56521338
46	Hypergonadotropic hypogonadism (HP:0000815)	2.53139791
47	Lower limb hyperreflexia (HP:0002395)	2.48785539
48	Myokymia (HP:0002411)	2.48657414
49	Muscle stiffness (HP:0003552)	2.38297090
50	Loss of speech (HP:0002371)	2.35798278
51	Short tibia (HP:0005736)	2.35506966
52	Oligodactyly (HP:0012165)	2.32313344
53	Posterior subcapsular cataract (HP:0007787)	2.25306035
54	Abnormal respiratory motile cilium physiology (HP:0012261)	2.23715866
55	Thyroid carcinoma (HP:0002890)	2.22089169
56	Abnormality of the septum pellucidum (HP:0007375)	2.20348061
57	Abnormality of the labia minora (HP:0012880)	2.18817712
58	Intrahepatic cholestasis (HP:0001406)	2.16902270
59	Anhidrosis (HP:0000970)	2.07991880
60	Conjunctival telangiectasia (HP:0000524)	2.06936144
61	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06819393
62	Abnormal lung lobation (HP:0002101)	2.05159200
63	Rhinitis (HP:0012384)	2.04889160
64	Subcapsular cataract (HP:0000523)	2.03268250
65	Rickets (HP:0002748)	2.02996023
66	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.02813151
67	Abnormality of the anterior chamber (HP:0000593)	2.01934074
68	Secondary amenorrhea (HP:0000869)	2.00589580
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.00510002
70	Dysdiadochokinesis (HP:0002075)	1.99211885
71	Striae distensae (HP:0001065)	1.99129584
72	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.97879506
73	Absent/shortened dynein arms (HP:0200106)	1.96417710
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96417710
75	Hydroureter (HP:0000072)	1.94774880
76	Hypercortisolism (HP:0001578)	1.94659612
77	Nephroblastoma (Wilms tumor) (HP:0002667)	1.94636272
78	Bile duct proliferation (HP:0001408)	1.90676318
79	Abnormal biliary tract physiology (HP:0012439)	1.90676318
80	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.90542696
81	Maternal diabetes (HP:0009800)	1.89249315
82	Sensory axonal neuropathy (HP:0003390)	1.88826149
83	Enlarged penis (HP:0000040)	1.87846616
84	Bundle branch block (HP:0011710)	1.87521272
85	Preauricular pit (HP:0004467)	1.85745970
86	Periauricular skin pits (HP:0100277)	1.85745970
87	Nausea (HP:0002018)	1.83182257
88	Embryonal renal neoplasm (HP:0011794)	1.81980252
89	Increased circulating renin level (HP:0000848)	1.81890999
90	Cleft eyelid (HP:0000625)	1.81780961
91	Congenital sensorineural hearing impairment (HP:0008527)	1.80381365
92	Abnormality of the phalanges of the hallux (HP:0010057)	1.77948511
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77382501
94	Abnormality of the preputium (HP:0100587)	1.77142697
95	Duodenal stenosis (HP:0100867)	1.76894754
96	Small intestinal stenosis (HP:0012848)	1.76894754
97	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.76756545
98	Limb hypertonia (HP:0002509)	1.76411435
99	Hyperactive renin-angiotensin system (HP:0000841)	1.74654697
100	Abnormality of chromosome stability (HP:0003220)	1.73249755

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.28055442
2	ARAF	5.42013777
3	MAP3K13	5.39477280
4	CDK12	3.46514744
5	TTK	3.21019412
6	NEK6	3.03848281
7	STK24	3.02453629
8	BRAF	2.76194181
9	TAOK3	2.69745754
10	AURKA	2.48011372
11	CDC7	2.29614053
12	BUB1	2.22269105
13	MOS	2.19481216
14	MET	2.10176207
15	KSR2	1.98161158
16	TRIM28	1.81427300
17	CDK9	1.67857317
18	CDK7	1.65262121
19	MELK	1.58448147
20	RAF1	1.58260877
21	PRKCI	1.55437277
22	NEK2	1.53894846
23	PLK1	1.48367986
24	NTRK2	1.44455449
25	BRSK1	1.38973050
26	CDK19	1.26634677
27	STK3	1.23871839
28	PTK2	1.18663694
29	EIF2AK3	1.12755387
30	CHEK1	1.10503987
31	MAP3K8	1.05280794
32	KSR1	1.04233723
33	EEF2K	1.01285868
34	TNIK	1.00951261
35	CDK8	0.96439847
36	ZAK	0.92373695
37	NEK1	0.92288886
38	AURKB	0.87685134
39	PIM1	0.84827011
40	CHEK2	0.83066676
41	WNK1	0.81599576
42	TNK2	0.78528409
43	CSNK1G1	0.77688263
44	PLK3	0.77220733
45	CDK2	0.76088618
46	MARK3	0.71868593
47	MST4	0.70096225
48	CAMK1D	0.69956168
49	ATM	0.68729486
50	PBK	0.67827111
51	PAK1	0.65928110
52	MTOR	0.65585581
53	MAPKAPK3	0.65027033
54	BRSK2	0.58454311
55	SRPK1	0.57768935
56	DMPK	0.57647373
57	NUAK1	0.57455349
58	CSNK1G3	0.57396282
59	CDK1	0.55848336
60	NTRK3	0.55304715
61	LRRK2	0.54289218
62	ATR	0.53206517
63	TGFBR1	0.52910239
64	CSNK1E	0.49264456
65	CSNK1D	0.49087573
66	CAMK1G	0.46682453
67	BMPR1B	0.46662778
68	NME1	0.45004146
69	PRKG1	0.44700505
70	PRKCZ	0.43628814
71	BRD4	0.42789815
72	PLK4	0.42398235
73	ACVR1B	0.39881185
74	CSNK1A1L	0.39194665
75	TLK1	0.38585010
76	AKT2	0.36797744
77	STK39	0.36054797
78	CSNK1G2	0.35984661
79	PKN1	0.34965481
80	TIE1	0.34633722
81	MAP3K5	0.34058623
82	TESK2	0.32804664
83	PDK1	0.31501299
84	PRKACB	0.31007184
85	VRK1	0.29740424
86	GSK3B	0.28872453
87	MAPK13	0.26790983
88	NEK9	0.24840740
89	CDK5	0.24610447
90	LATS1	0.23537978
91	MAPK10	0.22967486
92	MAPK11	0.22861828
93	TYRO3	0.22827575
94	PRKD3	0.21944442
95	PDPK1	0.21366843
96	MAPK1	0.19504991
97	STK4	0.17121356
98	PRKACA	0.16999765
99	CLK1	0.16946400
100	CSNK2A2	0.16063176

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.18790342
2	Cell cycle_Homo sapiens_hsa04110	4.35227992
3	Mismatch repair_Homo sapiens_hsa03430	4.10262745
4	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.69638900
5	Base excision repair_Homo sapiens_hsa03410	3.34920281
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.16703601
7	Oocyte meiosis_Homo sapiens_hsa04114	3.14539787
8	DNA replication_Homo sapiens_hsa03030	3.10986264
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.55765606
10	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.55108353
11	RNA degradation_Homo sapiens_hsa03018	2.50497341
12	Caffeine metabolism_Homo sapiens_hsa00232	2.44422150
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.39053040
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.26005654
15	Homologous recombination_Homo sapiens_hsa03440	2.20737464
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.18967933
17	RNA transport_Homo sapiens_hsa03013	2.16347919
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.11636943
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.99114054
20	p53 signaling pathway_Homo sapiens_hsa04115	1.89968458
21	RNA polymerase_Homo sapiens_hsa03020	1.72068987
22	Folate biosynthesis_Homo sapiens_hsa00790	1.65506255
23	Olfactory transduction_Homo sapiens_hsa04740	1.59981841
24	mRNA surveillance pathway_Homo sapiens_hsa03015	1.57479647
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.50683189
26	Circadian rhythm_Homo sapiens_hsa04710	1.48784583
27	Gap junction_Homo sapiens_hsa04540	1.47594413
28	Thyroid cancer_Homo sapiens_hsa05216	1.38281633
29	Phototransduction_Homo sapiens_hsa04744	1.27041476
30	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.21522929
31	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.03072671
32	ABC transporters_Homo sapiens_hsa02010	0.94230218
33	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.92258609
34	Fatty acid elongation_Homo sapiens_hsa00062	0.89595545
35	Taste transduction_Homo sapiens_hsa04742	0.87151198
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83080246
37	Purine metabolism_Homo sapiens_hsa00230	0.80929392
38	mTOR signaling pathway_Homo sapiens_hsa04150	0.77837548
39	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.74111151
40	Bile secretion_Homo sapiens_hsa04976	0.71287511
41	Nicotine addiction_Homo sapiens_hsa05033	0.68922443
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.61328036
43	MicroRNAs in cancer_Homo sapiens_hsa05206	0.59250470
44	Spliceosome_Homo sapiens_hsa03040	0.58296660
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57805113
46	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.57720604
47	Huntingtons disease_Homo sapiens_hsa05016	0.55598908
48	Adherens junction_Homo sapiens_hsa04520	0.54388418
49	Morphine addiction_Homo sapiens_hsa05032	0.51808384
50	FoxO signaling pathway_Homo sapiens_hsa04068	0.51595164
51	Arginine biosynthesis_Homo sapiens_hsa00220	0.51230378
52	Ribosome_Homo sapiens_hsa03010	0.45980236
53	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.45913116
54	Viral carcinogenesis_Homo sapiens_hsa05203	0.45731485
55	GABAergic synapse_Homo sapiens_hsa04727	0.45285955
56	Wnt signaling pathway_Homo sapiens_hsa04310	0.43809587
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43775741
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42525226
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.41260229
60	Serotonergic synapse_Homo sapiens_hsa04726	0.40472815
61	Notch signaling pathway_Homo sapiens_hsa04330	0.39809374
62	Long-term depression_Homo sapiens_hsa04730	0.38747215
63	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.35523334
64	Herpes simplex infection_Homo sapiens_hsa05168	0.33972840
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.31654218
66	Lysine degradation_Homo sapiens_hsa00310	0.30127424
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28809785
68	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.28696686
69	Small cell lung cancer_Homo sapiens_hsa05222	0.27743225
70	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.24697562
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.23953830
72	ErbB signaling pathway_Homo sapiens_hsa04012	0.22646565
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.21511048
74	HTLV-I infection_Homo sapiens_hsa05166	0.18609703
75	Regulation of autophagy_Homo sapiens_hsa04140	0.17537274
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.17482172
77	Endometrial cancer_Homo sapiens_hsa05213	0.17174469
78	Tight junction_Homo sapiens_hsa04530	0.16759102
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.16090067
80	Protein digestion and absorption_Homo sapiens_hsa04974	0.15822868
81	Propanoate metabolism_Homo sapiens_hsa00640	0.15745775
82	Ras signaling pathway_Homo sapiens_hsa04014	0.11617491
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.10415691
84	Prostate cancer_Homo sapiens_hsa05215	0.08972603
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.08459708
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.07352657
87	Metabolic pathways_Homo sapiens_hsa01100	0.07181213
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.06505194
89	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.06304596
90	Non-small cell lung cancer_Homo sapiens_hsa05223	0.05036873
91	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.04773951
92	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.04221023
93	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.04060013
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.03356543
95	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.03087118
96	Insulin signaling pathway_Homo sapiens_hsa04910	0.03067025
97	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.02822890
98	Histidine metabolism_Homo sapiens_hsa00340	0.02378550
99	Renal cell carcinoma_Homo sapiens_hsa05211	0.00080384
100	Pyruvate metabolism_Homo sapiens_hsa00620	-0.0006560

TUBBP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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