

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | microtubule depolymerization (GO:0007019) | 5.14083275 |
| 2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.00303326 |
| 3 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.94931763 |
| 4 | NADH dehydrogenase complex assembly (GO:0010257) | 4.94931763 |
| 5 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.94931763 |
| 6 | protein complex biogenesis (GO:0070271) | 4.52144314 |
| 7 | DNA double-strand break processing (GO:0000729) | 4.44529898 |
| 8 | ribosomal small subunit assembly (GO:0000028) | 4.35255100 |
| 9 | ATP synthesis coupled proton transport (GO:0015986) | 4.28220075 |
| 10 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.28220075 |
| 11 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.22625902 |
| 12 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.22608157 |
| 13 | sequestering of actin monomers (GO:0042989) | 3.99450315 |
| 14 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.97830288 |
| 15 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.97830288 |
| 16 | pseudouridine synthesis (GO:0001522) | 3.92682510 |
| 17 | chromatin remodeling at centromere (GO:0031055) | 3.90681250 |
| 18 | chaperone-mediated protein transport (GO:0072321) | 3.90580541 |
| 19 | CENP-A containing nucleosome assembly (GO:0034080) | 3.82469483 |
| 20 | mitotic metaphase plate congression (GO:0007080) | 3.77475809 |
| 21 | proteasome assembly (GO:0043248) | 3.74643273 |
| 22 | protein neddylation (GO:0045116) | 3.64468815 |
| 23 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.53468097 |
| 24 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 3.50174159 |
| 25 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.48103871 |
| 26 | metaphase plate congression (GO:0051310) | 3.41567726 |
| 27 | establishment of integrated proviral latency (GO:0075713) | 3.36618591 |
| 28 | dopaminergic neuron differentiation (GO:0071542) | 3.35344501 |
| 29 | histone exchange (GO:0043486) | 3.30107266 |
| 30 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.25511014 |
| 31 | adaptation of signaling pathway (GO:0023058) | 3.20165306 |
| 32 | microtubule polymerization or depolymerization (GO:0031109) | 3.19266719 |
| 33 | DNA damage response, detection of DNA damage (GO:0042769) | 3.16548553 |
| 34 | replication fork processing (GO:0031297) | 3.13359433 |
| 35 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.11168588 |
| 36 | respiratory electron transport chain (GO:0022904) | 3.07522173 |
| 37 | mitotic sister chromatid segregation (GO:0000070) | 3.06151738 |
| 38 | electron transport chain (GO:0022900) | 3.05644541 |
| 39 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.04061065 |
| 40 | DNA replication checkpoint (GO:0000076) | 2.97255280 |
| 41 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.93707722 |
| 42 | termination of RNA polymerase III transcription (GO:0006386) | 2.93707722 |
| 43 | protein K6-linked ubiquitination (GO:0085020) | 2.92406408 |
| 44 | positive regulation of gastrulation (GO:2000543) | 2.91531310 |
| 45 | establishment of viral latency (GO:0019043) | 2.90816624 |
| 46 | regulation of feeding behavior (GO:0060259) | 2.89684435 |
| 47 | regulation of timing of cell differentiation (GO:0048505) | 2.89379160 |
| 48 | somite rostral/caudal axis specification (GO:0032525) | 2.88574895 |
| 49 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.88257726 |
| 50 | neurofilament cytoskeleton organization (GO:0060052) | 2.84727963 |
| 51 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.84534524 |
| 52 | base-excision repair, AP site formation (GO:0006285) | 2.83003884 |
| 53 | organelle disassembly (GO:1903008) | 2.81952361 |
| 54 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.79876801 |
| 55 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.79750928 |
| 56 | respiratory chain complex IV assembly (GO:0008535) | 2.79518224 |
| 57 | negative regulation of DNA-templated transcription, elongation (GO:0032785) | 2.77822359 |
| 58 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.77333528 |
| 59 | translational termination (GO:0006415) | 2.76653350 |
| 60 | spliceosomal snRNP assembly (GO:0000387) | 2.76113091 |
| 61 | DNA replication-independent nucleosome organization (GO:0034724) | 2.74750172 |
| 62 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.74750172 |
| 63 | DNA strand elongation (GO:0022616) | 2.74206362 |
| 64 | intracellular protein transmembrane import (GO:0044743) | 2.72184404 |
| 65 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.72111885 |
| 66 | DNA strand renaturation (GO:0000733) | 2.71207578 |
| 67 | GTP biosynthetic process (GO:0006183) | 2.71107126 |
| 68 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.66760265 |
| 69 | sister chromatid segregation (GO:0000819) | 2.66687609 |
| 70 | negative regulation of DNA recombination (GO:0045910) | 2.66223826 |
| 71 | regulation of development, heterochronic (GO:0040034) | 2.65144207 |
| 72 | DNA ligation (GO:0006266) | 2.64855439 |
| 73 | negative regulation of ligase activity (GO:0051352) | 2.64190831 |
| 74 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.64190831 |
| 75 | viral transcription (GO:0019083) | 2.63280637 |
| 76 | IMP biosynthetic process (GO:0006188) | 2.62302444 |
| 77 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.62005116 |
| 78 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.61069052 |
| 79 | DNA deamination (GO:0045006) | 2.60688992 |
| 80 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.59276265 |
| 81 | protein localization to kinetochore (GO:0034501) | 2.56385051 |
| 82 | cellular component biogenesis (GO:0044085) | 2.56370130 |
| 83 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.56104324 |
| 84 | establishment of chromosome localization (GO:0051303) | 2.56002008 |
| 85 | regulation of meiosis I (GO:0060631) | 2.54636573 |
| 86 | behavioral response to nicotine (GO:0035095) | 2.54460626 |
| 87 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.53055612 |
| 88 | meiotic chromosome segregation (GO:0045132) | 2.51008470 |
| 89 | limb bud formation (GO:0060174) | 2.48044979 |
| 90 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.47443195 |
| 91 | somite development (GO:0061053) | 2.44533438 |
| 92 | UTP biosynthetic process (GO:0006228) | 2.44418911 |
| 93 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.43414418 |
| 94 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.42929219 |
| 95 | termination of RNA polymerase I transcription (GO:0006363) | 2.42720476 |
| 96 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.42323395 |
| 97 | cellular protein complex disassembly (GO:0043624) | 2.42172897 |
| 98 | hyperosmotic salinity response (GO:0042538) | 2.42094964 |
| 99 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.42030581 |
| 100 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.42030581 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.43561037 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.99725906 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.79503683 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.71493369 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.39040541 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.01727371 |
| 7 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.91491869 |
| 8 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.74275850 |
| 9 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.68721614 |
| 10 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.68018281 |
| 11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.53406800 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.40546600 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.35404366 |
| 14 | EWS_26573619_Chip-Seq_HEK293_Human | 2.33180803 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.32821976 |
| 16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.28687788 |
| 17 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.27255031 |
| 18 | VDR_22108803_ChIP-Seq_LS180_Human | 2.25302351 |
| 19 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.23168788 |
| 20 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.21580373 |
| 21 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.20456237 |
| 22 | FUS_26573619_Chip-Seq_HEK293_Human | 2.09940969 |
| 23 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.09761562 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.09395073 |
| 25 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.98139911 |
| 26 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.96888570 |
| 27 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.89634651 |
| 28 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.77925877 |
| 29 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.74710193 |
| 30 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.68097057 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.62779270 |
| 32 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.62074767 |
| 33 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.57504776 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.56619058 |
| 35 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.54640161 |
| 36 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.52344998 |
| 37 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.51703934 |
| 38 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.51469142 |
| 39 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.49660494 |
| 40 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.49402064 |
| 41 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.49117424 |
| 42 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.47071802 |
| 43 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.46712931 |
| 44 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.44298216 |
| 45 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.42685031 |
| 46 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.42540159 |
| 47 | P300_19829295_ChIP-Seq_ESCs_Human | 1.41318282 |
| 48 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.38110687 |
| 49 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.36638715 |
| 50 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.35863265 |
| 51 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.35728979 |
| 52 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.35276513 |
| 53 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.34603973 |
| 54 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.31525004 |
| 55 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.28196437 |
| 56 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.27958851 |
| 57 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.24238046 |
| 58 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.24146070 |
| 59 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.23709401 |
| 60 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.23632350 |
| 61 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.21698063 |
| 62 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.21632670 |
| 63 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.20845542 |
| 64 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.20560453 |
| 65 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.20380883 |
| 66 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.18760043 |
| 67 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.14405003 |
| 68 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.13152783 |
| 69 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.10780675 |
| 70 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.08988367 |
| 71 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08203755 |
| 72 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.07935615 |
| 73 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.07131748 |
| 74 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.06246907 |
| 75 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.05077883 |
| 76 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.05060458 |
| 77 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04943150 |
| 78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.03602188 |
| 79 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.03535841 |
| 80 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.03524445 |
| 81 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.00958084 |
| 82 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.00849705 |
| 83 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.00593103 |
| 84 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.00102816 |
| 85 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.98285240 |
| 86 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.97304113 |
| 87 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.96427496 |
| 88 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.95139433 |
| 89 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.95015480 |
| 90 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.94487666 |
| 91 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.92989564 |
| 92 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.92342829 |
| 93 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.91684762 |
| 94 | REST_21632747_ChIP-Seq_MESCs_Mouse | 0.90979063 |
| 95 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.90753644 |
| 96 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.90753644 |
| 97 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.89123436 |
| 98 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.89075212 |
| 99 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.86809887 |
| 100 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.86608464 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000566_synostosis | 4.76476440 |
| 2 | MP0000569_abnormal_digit_pigmentation | 3.50584473 |
| 3 | MP0002102_abnormal_ear_morphology | 3.00431518 |
| 4 | MP0003693_abnormal_embryo_hatching | 2.91458937 |
| 5 | MP0006072_abnormal_retinal_apoptosis | 2.75943607 |
| 6 | MP0001529_abnormal_vocalization | 2.54659054 |
| 7 | MP0000049_abnormal_middle_ear | 2.43542007 |
| 8 | MP0003567_abnormal_fetal_cardiomyocyte | 2.40703642 |
| 9 | MP0008058_abnormal_DNA_repair | 2.26127977 |
| 10 | MP0010094_abnormal_chromosome_stability | 2.21732875 |
| 11 | MP0008877_abnormal_DNA_methylation | 2.14266248 |
| 12 | MP0006292_abnormal_olfactory_placode | 2.00847023 |
| 13 | MP0002234_abnormal_pharynx_morphology | 1.91517147 |
| 14 | MP0005646_abnormal_pituitary_gland | 1.90363845 |
| 15 | MP0001485_abnormal_pinna_reflex | 1.83091115 |
| 16 | MP0002938_white_spotting | 1.82432948 |
| 17 | MP0010030_abnormal_orbit_morphology | 1.80479547 |
| 18 | MP0003880_abnormal_central_pattern | 1.71978947 |
| 19 | MP0008789_abnormal_olfactory_epithelium | 1.69957758 |
| 20 | MP0005084_abnormal_gallbladder_morpholo | 1.66907719 |
| 21 | MP0004957_abnormal_blastocyst_morpholog | 1.66837622 |
| 22 | MP0002736_abnormal_nociception_after | 1.63409362 |
| 23 | MP0001293_anophthalmia | 1.60729589 |
| 24 | MP0003937_abnormal_limbs/digits/tail_de | 1.59425320 |
| 25 | MP0003315_abnormal_perineum_morphology | 1.58390131 |
| 26 | MP0001968_abnormal_touch/_nociception | 1.54846201 |
| 27 | MP0002822_catalepsy | 1.54425732 |
| 28 | MP0009046_muscle_twitch | 1.54261960 |
| 29 | MP0002272_abnormal_nervous_system | 1.52922630 |
| 30 | MP0001905_abnormal_dopamine_level | 1.51607087 |
| 31 | MP0005253_abnormal_eye_physiology | 1.48752709 |
| 32 | MP0009745_abnormal_behavioral_response | 1.43664728 |
| 33 | MP0008932_abnormal_embryonic_tissue | 1.42475512 |
| 34 | MP0003111_abnormal_nucleus_morphology | 1.40992004 |
| 35 | MP0004742_abnormal_vestibular_system | 1.38121572 |
| 36 | MP0003119_abnormal_digestive_system | 1.37796025 |
| 37 | MP0003718_maternal_effect | 1.37642348 |
| 38 | MP0002735_abnormal_chemical_nociception | 1.36882304 |
| 39 | MP0003938_abnormal_ear_development | 1.36741870 |
| 40 | MP0003136_yellow_coat_color | 1.35562165 |
| 41 | MP0003806_abnormal_nucleotide_metabolis | 1.35448239 |
| 42 | MP0001346_abnormal_lacrimal_gland | 1.34327586 |
| 43 | MP0002751_abnormal_autonomic_nervous | 1.33901052 |
| 44 | MP0003077_abnormal_cell_cycle | 1.31905813 |
| 45 | MP0005394_taste/olfaction_phenotype | 1.31367221 |
| 46 | MP0005499_abnormal_olfactory_system | 1.31367221 |
| 47 | MP0003121_genomic_imprinting | 1.26268499 |
| 48 | MP0004142_abnormal_muscle_tone | 1.24580683 |
| 49 | MP0002210_abnormal_sex_determination | 1.22652561 |
| 50 | MP0003122_maternal_imprinting | 1.22304358 |
| 51 | MP0000778_abnormal_nervous_system | 1.21563605 |
| 52 | MP0008995_early_reproductive_senescence | 1.19649145 |
| 53 | MP0004133_heterotaxia | 1.15973102 |
| 54 | MP0005423_abnormal_somatic_nervous | 1.14923117 |
| 55 | MP0003890_abnormal_embryonic-extraembry | 1.14381754 |
| 56 | MP0009697_abnormal_copulation | 1.14357495 |
| 57 | MP0004885_abnormal_endolymph | 1.13565468 |
| 58 | MP0000631_abnormal_neuroendocrine_gland | 1.12927325 |
| 59 | MP0002233_abnormal_nose_morphology | 1.10253205 |
| 60 | MP0006276_abnormal_autonomic_nervous | 1.09870586 |
| 61 | MP0000026_abnormal_inner_ear | 1.08260714 |
| 62 | MP0002572_abnormal_emotion/affect_behav | 1.07518677 |
| 63 | MP0005551_abnormal_eye_electrophysiolog | 1.06967650 |
| 64 | MP0003186_abnormal_redox_activity | 1.06687939 |
| 65 | MP0008007_abnormal_cellular_replicative | 1.06360335 |
| 66 | MP0001486_abnormal_startle_reflex | 1.04107015 |
| 67 | MP0005171_absent_coat_pigmentation | 0.99894115 |
| 68 | MP0002557_abnormal_social/conspecific_i | 0.94107482 |
| 69 | MP0006035_abnormal_mitochondrial_morpho | 0.93949843 |
| 70 | MP0002282_abnormal_trachea_morphology | 0.93822464 |
| 71 | MP0003635_abnormal_synaptic_transmissio | 0.92859699 |
| 72 | MP0002733_abnormal_thermal_nociception | 0.91679743 |
| 73 | MP0005187_abnormal_penis_morphology | 0.91575533 |
| 74 | MP0002163_abnormal_gland_morphology | 0.91352692 |
| 75 | MP0005391_vision/eye_phenotype | 0.90668029 |
| 76 | MP0000653_abnormal_sex_gland | 0.89649829 |
| 77 | MP0001929_abnormal_gametogenesis | 0.89570470 |
| 78 | MP0002067_abnormal_sensory_capabilities | 0.89010720 |
| 79 | MP0001188_hyperpigmentation | 0.88826826 |
| 80 | MP0002752_abnormal_somatic_nervous | 0.88076334 |
| 81 | MP0000372_irregular_coat_pigmentation | 0.87318218 |
| 82 | MP0001145_abnormal_male_reproductive | 0.84243943 |
| 83 | MP0004147_increased_porphyrin_level | 0.83862800 |
| 84 | MP0002064_seizures | 0.83152375 |
| 85 | MP0005195_abnormal_posterior_eye | 0.82799496 |
| 86 | MP0003861_abnormal_nervous_system | 0.81206759 |
| 87 | MP0003787_abnormal_imprinting | 0.81100574 |
| 88 | MP0001119_abnormal_female_reproductive | 0.80932316 |
| 89 | MP0002277_abnormal_respiratory_mucosa | 0.80857336 |
| 90 | MP0002638_abnormal_pupillary_reflex | 0.79873837 |
| 91 | MP0001286_abnormal_eye_development | 0.78784443 |
| 92 | MP0001963_abnormal_hearing_physiology | 0.77323723 |
| 93 | MP0002184_abnormal_innervation | 0.76969157 |
| 94 | MP0003786_premature_aging | 0.75946485 |
| 95 | MP0002734_abnormal_mechanical_nocicepti | 0.75683759 |
| 96 | MP0004924_abnormal_behavior | 0.75631257 |
| 97 | MP0005386_behavior/neurological_phenoty | 0.75631257 |
| 98 | MP0000516_abnormal_urinary_system | 0.74789675 |
| 99 | MP0005367_renal/urinary_system_phenotyp | 0.74789675 |
| 100 | MP0006036_abnormal_mitochondrial_physio | 0.72905220 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.74251419 |
| 2 | Reticulocytopenia (HP:0001896) | 4.47718191 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.32056089 |
| 4 | Acute encephalopathy (HP:0006846) | 4.27924365 |
| 5 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.19240812 |
| 6 | Meckel diverticulum (HP:0002245) | 4.08441972 |
| 7 | Abnormality of the labia minora (HP:0012880) | 4.00542585 |
| 8 | Abnormality of the ileum (HP:0001549) | 3.94490904 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.84921133 |
| 10 | Mitochondrial inheritance (HP:0001427) | 3.83044059 |
| 11 | Chromsome breakage (HP:0040012) | 3.79583079 |
| 12 | Increased CSF lactate (HP:0002490) | 3.56263923 |
| 13 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.43388302 |
| 14 | Duplicated collecting system (HP:0000081) | 3.20219001 |
| 15 | Abnormality of the renal collecting system (HP:0004742) | 3.15710939 |
| 16 | Increased hepatocellular lipid droplets (HP:0006565) | 3.14492415 |
| 17 | Hepatocellular necrosis (HP:0001404) | 3.13165022 |
| 18 | Hepatic necrosis (HP:0002605) | 2.94249198 |
| 19 | Abnormality of the preputium (HP:0100587) | 2.93229251 |
| 20 | Small intestinal stenosis (HP:0012848) | 2.93113921 |
| 21 | Duodenal stenosis (HP:0100867) | 2.93113921 |
| 22 | Hyperglycinemia (HP:0002154) | 2.92555233 |
| 23 | Lipid accumulation in hepatocytes (HP:0006561) | 2.90093326 |
| 24 | Cerebral edema (HP:0002181) | 2.88421215 |
| 25 | Pancreatic cysts (HP:0001737) | 2.78808030 |
| 26 | True hermaphroditism (HP:0010459) | 2.73371214 |
| 27 | Congenital stationary night blindness (HP:0007642) | 2.72704674 |
| 28 | Abnormality of chromosome stability (HP:0003220) | 2.70579192 |
| 29 | Abnormal lung lobation (HP:0002101) | 2.69833179 |
| 30 | Intestinal atresia (HP:0011100) | 2.67363313 |
| 31 | Horseshoe kidney (HP:0000085) | 2.66410138 |
| 32 | Molar tooth sign on MRI (HP:0002419) | 2.60224426 |
| 33 | Abnormality of midbrain morphology (HP:0002418) | 2.60224426 |
| 34 | Optic disc pallor (HP:0000543) | 2.58985014 |
| 35 | Limb dystonia (HP:0002451) | 2.55251016 |
| 36 | Pancreatic fibrosis (HP:0100732) | 2.50926038 |
| 37 | Supernumerary spleens (HP:0009799) | 2.49811314 |
| 38 | Absent thumb (HP:0009777) | 2.46510530 |
| 39 | Congenital, generalized hypertrichosis (HP:0004540) | 2.45369199 |
| 40 | Abnormality of the duodenum (HP:0002246) | 2.45340583 |
| 41 | Renal Fanconi syndrome (HP:0001994) | 2.44425975 |
| 42 | Clubbing of toes (HP:0100760) | 2.42852716 |
| 43 | Hypoplasia of the pons (HP:0012110) | 2.33929510 |
| 44 | Triphalangeal thumb (HP:0001199) | 2.31969210 |
| 45 | Ectopic kidney (HP:0000086) | 2.31131521 |
| 46 | Aplasia involving forearm bones (HP:0009822) | 2.29729015 |
| 47 | Absent forearm bone (HP:0003953) | 2.29729015 |
| 48 | Absent radius (HP:0003974) | 2.25489970 |
| 49 | Nephronophthisis (HP:0000090) | 2.25399189 |
| 50 | Leukodystrophy (HP:0002415) | 2.23035652 |
| 51 | Abnormality of the carotid arteries (HP:0005344) | 2.18362335 |
| 52 | Septo-optic dysplasia (HP:0100842) | 2.14926330 |
| 53 | Increased serum pyruvate (HP:0003542) | 2.14092572 |
| 54 | Abnormality of the pons (HP:0007361) | 2.12904418 |
| 55 | Patellar aplasia (HP:0006443) | 2.12179232 |
| 56 | Humeroradial synostosis (HP:0003041) | 2.08443482 |
| 57 | Synostosis involving the elbow (HP:0003938) | 2.08443482 |
| 58 | Increased serum lactate (HP:0002151) | 2.06744895 |
| 59 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.05922390 |
| 60 | Absent septum pellucidum (HP:0001331) | 2.02849752 |
| 61 | Respiratory failure (HP:0002878) | 2.02436993 |
| 62 | Lactic acidosis (HP:0003128) | 2.00349841 |
| 63 | Pancytopenia (HP:0001876) | 1.99096004 |
| 64 | Colon cancer (HP:0003003) | 1.97458367 |
| 65 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.96638866 |
| 66 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.96638866 |
| 67 | Abnormality of DNA repair (HP:0003254) | 1.95453676 |
| 68 | Pendular nystagmus (HP:0012043) | 1.95154557 |
| 69 | Exercise intolerance (HP:0003546) | 1.91743768 |
| 70 | Inability to walk (HP:0002540) | 1.88740781 |
| 71 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.88177110 |
| 72 | Abnormality of glycolysis (HP:0004366) | 1.86437379 |
| 73 | Abnormal biliary tract physiology (HP:0012439) | 1.83432411 |
| 74 | Bile duct proliferation (HP:0001408) | 1.83432411 |
| 75 | Medial flaring of the eyebrow (HP:0010747) | 1.82132855 |
| 76 | Exertional dyspnea (HP:0002875) | 1.81845745 |
| 77 | Cortical dysplasia (HP:0002539) | 1.81544585 |
| 78 | Bilateral microphthalmos (HP:0007633) | 1.78931784 |
| 79 | Short thumb (HP:0009778) | 1.78085382 |
| 80 | Anencephaly (HP:0002323) | 1.77588453 |
| 81 | Hyperglycinuria (HP:0003108) | 1.76610660 |
| 82 | Sloping forehead (HP:0000340) | 1.75874913 |
| 83 | Methylmalonic acidemia (HP:0002912) | 1.74896645 |
| 84 | Birth length less than 3rd percentile (HP:0003561) | 1.74413209 |
| 85 | Stenosis of the external auditory canal (HP:0000402) | 1.74063820 |
| 86 | Abnormality of glycine metabolism (HP:0010895) | 1.72459867 |
| 87 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.72459867 |
| 88 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.71451034 |
| 89 | Abnormality of the septum pellucidum (HP:0007375) | 1.70401823 |
| 90 | Increased intramyocellular lipid droplets (HP:0012240) | 1.70102331 |
| 91 | X-linked dominant inheritance (HP:0001423) | 1.70001311 |
| 92 | Abnormality of the renal medulla (HP:0100957) | 1.69295728 |
| 93 | Abolished electroretinogram (ERG) (HP:0000550) | 1.68607954 |
| 94 | Aganglionic megacolon (HP:0002251) | 1.65657072 |
| 95 | Methylmalonic aciduria (HP:0012120) | 1.64328889 |
| 96 | Postaxial foot polydactyly (HP:0001830) | 1.64201053 |
| 97 | Oligodactyly (hands) (HP:0001180) | 1.63922259 |
| 98 | Carpal bone hypoplasia (HP:0001498) | 1.63573457 |
| 99 | Pallor (HP:0000980) | 1.63240961 |
| 100 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.62688589 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.15787801 |
| 2 | MAP4K2 | 3.30554272 |
| 3 | BUB1 | 2.98370763 |
| 4 | VRK1 | 2.94884658 |
| 5 | SRPK1 | 2.68446574 |
| 6 | ZAK | 2.45430530 |
| 7 | TAF1 | 2.43070506 |
| 8 | GRK1 | 2.41576184 |
| 9 | PNCK | 2.32641887 |
| 10 | DYRK2 | 2.18884269 |
| 11 | WEE1 | 2.18216732 |
| 12 | PLK3 | 2.14546471 |
| 13 | WNK3 | 2.09407599 |
| 14 | CDC7 | 2.04804712 |
| 15 | TSSK6 | 2.04270615 |
| 16 | TIE1 | 1.94104822 |
| 17 | BCR | 1.89069110 |
| 18 | TRIM28 | 1.88112232 |
| 19 | NUAK1 | 1.87028320 |
| 20 | MKNK2 | 1.83104140 |
| 21 | PLK4 | 1.81910443 |
| 22 | NME1 | 1.72259380 |
| 23 | PINK1 | 1.70381859 |
| 24 | STK16 | 1.69127865 |
| 25 | ADRBK2 | 1.67391241 |
| 26 | MARK1 | 1.65785819 |
| 27 | MKNK1 | 1.62947838 |
| 28 | CSNK1G3 | 1.50861574 |
| 29 | CCNB1 | 1.47290801 |
| 30 | INSRR | 1.46559811 |
| 31 | CSNK1G1 | 1.46324018 |
| 32 | BCKDK | 1.41848195 |
| 33 | TAOK3 | 1.40298733 |
| 34 | CSNK1G2 | 1.30457801 |
| 35 | BRSK2 | 1.25829457 |
| 36 | DYRK3 | 1.22520030 |
| 37 | NEK1 | 1.21053431 |
| 38 | PRKCG | 1.17879641 |
| 39 | MINK1 | 1.17394390 |
| 40 | TTK | 1.14093810 |
| 41 | TESK1 | 1.09888802 |
| 42 | EIF2AK3 | 1.04712214 |
| 43 | ERBB3 | 1.01963547 |
| 44 | PLK1 | 0.98533135 |
| 45 | MAPK15 | 0.98500611 |
| 46 | CSNK1A1L | 0.95956173 |
| 47 | MST4 | 0.92456490 |
| 48 | CHEK2 | 0.90874991 |
| 49 | AURKB | 0.87351711 |
| 50 | DAPK1 | 0.85745621 |
| 51 | BMPR1B | 0.85640407 |
| 52 | MAP3K4 | 0.84311281 |
| 53 | PLK2 | 0.81870729 |
| 54 | TLK1 | 0.78532283 |
| 55 | TNIK | 0.76884614 |
| 56 | BRSK1 | 0.75709162 |
| 57 | ATR | 0.74439173 |
| 58 | PDK2 | 0.72085715 |
| 59 | RPS6KA4 | 0.67084937 |
| 60 | RPS6KA5 | 0.67081815 |
| 61 | DYRK1A | 0.64817678 |
| 62 | CSNK1A1 | 0.63799922 |
| 63 | CDK19 | 0.63780722 |
| 64 | PASK | 0.62935512 |
| 65 | PBK | 0.59370013 |
| 66 | OXSR1 | 0.59024848 |
| 67 | KIT | 0.58266561 |
| 68 | AURKA | 0.57304696 |
| 69 | EIF2AK2 | 0.56967323 |
| 70 | STK39 | 0.55101074 |
| 71 | MAPKAPK5 | 0.52642489 |
| 72 | PRKCQ | 0.51021064 |
| 73 | FRK | 0.49357250 |
| 74 | MAPK13 | 0.47961857 |
| 75 | ADRBK1 | 0.47023965 |
| 76 | GRK5 | 0.46072805 |
| 77 | CASK | 0.44466803 |
| 78 | CSNK1E | 0.44408534 |
| 79 | CSNK2A1 | 0.43770969 |
| 80 | CSNK2A2 | 0.43008777 |
| 81 | EPHB2 | 0.42012379 |
| 82 | MAP2K7 | 0.41741286 |
| 83 | PRKG1 | 0.41357986 |
| 84 | ATM | 0.39470601 |
| 85 | EPHA4 | 0.39134391 |
| 86 | EIF2AK1 | 0.37572977 |
| 87 | PRKACB | 0.37042473 |
| 88 | CHEK1 | 0.37022533 |
| 89 | CDK14 | 0.36429995 |
| 90 | TGFBR1 | 0.35316633 |
| 91 | PAK3 | 0.34864982 |
| 92 | DAPK3 | 0.34810531 |
| 93 | PRKCE | 0.34612681 |
| 94 | NEK2 | 0.33858672 |
| 95 | CDK8 | 0.33707489 |
| 96 | PRKACA | 0.31818501 |
| 97 | WNK4 | 0.31183418 |
| 98 | CDK7 | 0.30616958 |
| 99 | PHKG2 | 0.30490622 |
| 100 | PHKG1 | 0.30490622 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.59594761 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 3.43139992 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.32110158 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.10472120 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.97151299 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.78745926 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.74948930 |
| 8 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.66612768 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.63954482 |
| 10 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.55758902 |
| 11 | Protein export_Homo sapiens_hsa03060 | 2.32218895 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.27697578 |
| 13 | RNA degradation_Homo sapiens_hsa03018 | 2.20248391 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 2.03416130 |
| 15 | Alzheimers disease_Homo sapiens_hsa05010 | 1.91137548 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.90970899 |
| 17 | Base excision repair_Homo sapiens_hsa03410 | 1.81354606 |
| 18 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.81227061 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.79312460 |
| 20 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.77079943 |
| 21 | RNA transport_Homo sapiens_hsa03013 | 1.76839078 |
| 22 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.67570219 |
| 23 | Nicotine addiction_Homo sapiens_hsa05033 | 1.60892274 |
| 24 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.57846774 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.56556913 |
| 26 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.49322259 |
| 27 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.46876548 |
| 28 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.45598355 |
| 29 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.45327883 |
| 30 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.44101922 |
| 31 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.38532787 |
| 32 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.28374053 |
| 33 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.27806106 |
| 34 | Phototransduction_Homo sapiens_hsa04744 | 1.25906576 |
| 35 | Cell cycle_Homo sapiens_hsa04110 | 1.24041302 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.20688226 |
| 37 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.20201690 |
| 38 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.16185081 |
| 39 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.15923128 |
| 40 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.14342115 |
| 41 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.04555831 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.04524793 |
| 43 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.95453579 |
| 44 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.90567592 |
| 45 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.85626026 |
| 46 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.83725826 |
| 47 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.81003314 |
| 48 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.79467893 |
| 49 | Peroxisome_Homo sapiens_hsa04146 | 0.76302054 |
| 50 | Taste transduction_Homo sapiens_hsa04742 | 0.75945313 |
| 51 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.75675133 |
| 52 | Alcoholism_Homo sapiens_hsa05034 | 0.73984676 |
| 53 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.73608134 |
| 54 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.73577659 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.71512947 |
| 56 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.70268370 |
| 57 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.68872105 |
| 58 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.67254055 |
| 59 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.66845592 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.65963847 |
| 61 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.64040054 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56920862 |
| 63 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.55368164 |
| 64 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.53223706 |
| 65 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.53091742 |
| 66 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.52657879 |
| 67 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.48743590 |
| 68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.48711888 |
| 69 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.48620478 |
| 70 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48527015 |
| 71 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.47773433 |
| 72 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.47437524 |
| 73 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.46168291 |
| 74 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.45403722 |
| 75 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.45079749 |
| 76 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.43685171 |
| 77 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.42592045 |
| 78 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.42525818 |
| 79 | GABAergic synapse_Homo sapiens_hsa04727 | 0.41855632 |
| 80 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.41795119 |
| 81 | Olfactory transduction_Homo sapiens_hsa04740 | 0.41777255 |
| 82 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.41545829 |
| 83 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.40959899 |
| 84 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.39487877 |
| 85 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.35120471 |
| 86 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.34796650 |
| 87 | Carbon metabolism_Homo sapiens_hsa01200 | 0.34034078 |
| 88 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.31408196 |
| 89 | Retinol metabolism_Homo sapiens_hsa00830 | 0.31005924 |
| 90 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.30534333 |
| 91 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.30164945 |
| 92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.29707591 |
| 93 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.27859048 |
| 94 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.27672719 |
| 95 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27130193 |
| 96 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.26096514 |
| 97 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.24917293 |
| 98 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.23306077 |
| 99 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.20807838 |
| 100 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.20181463 |

