TUBBP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microtubule depolymerization (GO:0007019)5.14083275
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.00303326
3mitochondrial respiratory chain complex I assembly (GO:0032981)4.94931763
4NADH dehydrogenase complex assembly (GO:0010257)4.94931763
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.94931763
6protein complex biogenesis (GO:0070271)4.52144314
7DNA double-strand break processing (GO:0000729)4.44529898
8ribosomal small subunit assembly (GO:0000028)4.35255100
9ATP synthesis coupled proton transport (GO:0015986)4.28220075
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.28220075
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22625902
12mitochondrial respiratory chain complex assembly (GO:0033108)4.22608157
13sequestering of actin monomers (GO:0042989)3.99450315
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.97830288
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.97830288
16pseudouridine synthesis (GO:0001522)3.92682510
17chromatin remodeling at centromere (GO:0031055)3.90681250
18chaperone-mediated protein transport (GO:0072321)3.90580541
19CENP-A containing nucleosome assembly (GO:0034080)3.82469483
20mitotic metaphase plate congression (GO:0007080)3.77475809
21proteasome assembly (GO:0043248)3.74643273
22protein neddylation (GO:0045116)3.64468815
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53468097
24negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.50174159
25DNA catabolic process, exonucleolytic (GO:0000738)3.48103871
26metaphase plate congression (GO:0051310)3.41567726
27establishment of integrated proviral latency (GO:0075713)3.36618591
28dopaminergic neuron differentiation (GO:0071542)3.35344501
29histone exchange (GO:0043486)3.30107266
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25511014
31adaptation of signaling pathway (GO:0023058)3.20165306
32microtubule polymerization or depolymerization (GO:0031109)3.19266719
33DNA damage response, detection of DNA damage (GO:0042769)3.16548553
34replication fork processing (GO:0031297)3.13359433
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11168588
36respiratory electron transport chain (GO:0022904)3.07522173
37mitotic sister chromatid segregation (GO:0000070)3.06151738
38electron transport chain (GO:0022900)3.05644541
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04061065
40DNA replication checkpoint (GO:0000076)2.97255280
41transcription elongation from RNA polymerase III promoter (GO:0006385)2.93707722
42termination of RNA polymerase III transcription (GO:0006386)2.93707722
43protein K6-linked ubiquitination (GO:0085020)2.92406408
44positive regulation of gastrulation (GO:2000543)2.91531310
45establishment of viral latency (GO:0019043)2.90816624
46regulation of feeding behavior (GO:0060259)2.89684435
47regulation of timing of cell differentiation (GO:0048505)2.89379160
48somite rostral/caudal axis specification (GO:0032525)2.88574895
49negative regulation of DNA-dependent DNA replication (GO:2000104)2.88257726
50neurofilament cytoskeleton organization (GO:0060052)2.84727963
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84534524
52base-excision repair, AP site formation (GO:0006285)2.83003884
53organelle disassembly (GO:1903008)2.81952361
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79876801
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79750928
56respiratory chain complex IV assembly (GO:0008535)2.79518224
57negative regulation of DNA-templated transcription, elongation (GO:0032785)2.77822359
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77333528
59translational termination (GO:0006415)2.76653350
60spliceosomal snRNP assembly (GO:0000387)2.76113091
61DNA replication-independent nucleosome organization (GO:0034724)2.74750172
62DNA replication-independent nucleosome assembly (GO:0006336)2.74750172
63DNA strand elongation (GO:0022616)2.74206362
64intracellular protein transmembrane import (GO:0044743)2.72184404
65DNA strand elongation involved in DNA replication (GO:0006271)2.72111885
66DNA strand renaturation (GO:0000733)2.71207578
67GTP biosynthetic process (GO:0006183)2.71107126
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66760265
69sister chromatid segregation (GO:0000819)2.66687609
70negative regulation of DNA recombination (GO:0045910)2.66223826
71regulation of development, heterochronic (GO:0040034)2.65144207
72DNA ligation (GO:0006266)2.64855439
73negative regulation of ligase activity (GO:0051352)2.64190831
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64190831
75viral transcription (GO:0019083)2.63280637
76IMP biosynthetic process (GO:0006188)2.62302444
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62005116
78telomere maintenance via semi-conservative replication (GO:0032201)2.61069052
79DNA deamination (GO:0045006)2.60688992
80regulation of double-strand break repair via homologous recombination (GO:0010569)2.59276265
81protein localization to kinetochore (GO:0034501)2.56385051
82cellular component biogenesis (GO:0044085)2.56370130
83pyrimidine nucleobase catabolic process (GO:0006208)2.56104324
84establishment of chromosome localization (GO:0051303)2.56002008
85regulation of meiosis I (GO:0060631)2.54636573
86behavioral response to nicotine (GO:0035095)2.54460626
87pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.53055612
88meiotic chromosome segregation (GO:0045132)2.51008470
89limb bud formation (GO:0060174)2.48044979
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.47443195
91somite development (GO:0061053)2.44533438
92UTP biosynthetic process (GO:0006228)2.44418911
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43414418
94purine nucleoside triphosphate biosynthetic process (GO:0009145)2.42929219
95termination of RNA polymerase I transcription (GO:0006363)2.42720476
96transcription elongation from RNA polymerase I promoter (GO:0006362)2.42323395
97cellular protein complex disassembly (GO:0043624)2.42172897
98hyperosmotic salinity response (GO:0042538)2.42094964
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.42030581
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.42030581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43561037
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.99725906
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.79503683
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71493369
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39040541
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01727371
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91491869
8E2F7_22180533_ChIP-Seq_HELA_Human2.74275850
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.68721614
10EZH2_22144423_ChIP-Seq_EOC_Human2.68018281
11ELK1_19687146_ChIP-ChIP_HELA_Human2.53406800
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40546600
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35404366
14EWS_26573619_Chip-Seq_HEK293_Human2.33180803
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32821976
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28687788
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27255031
18VDR_22108803_ChIP-Seq_LS180_Human2.25302351
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.23168788
20ZNF274_21170338_ChIP-Seq_K562_Hela2.21580373
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.20456237
22FUS_26573619_Chip-Seq_HEK293_Human2.09940969
23IGF1R_20145208_ChIP-Seq_DFB_Human2.09761562
24VDR_23849224_ChIP-Seq_CD4+_Human2.09395073
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98139911
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.96888570
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89634651
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77925877
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.74710193
30MYC_18940864_ChIP-ChIP_HL60_Human1.68097057
31FOXP3_21729870_ChIP-Seq_TREG_Human1.62779270
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62074767
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57504776
34TTF2_22483619_ChIP-Seq_HELA_Human1.56619058
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54640161
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52344998
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.51703934
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51469142
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49660494
40GBX2_23144817_ChIP-Seq_PC3_Human1.49402064
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49117424
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47071802
43DCP1A_22483619_ChIP-Seq_HELA_Human1.46712931
44XRN2_22483619_ChIP-Seq_HELA_Human1.44298216
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42685031
46IRF1_19129219_ChIP-ChIP_H3396_Human1.42540159
47P300_19829295_ChIP-Seq_ESCs_Human1.41318282
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38110687
49TAF15_26573619_Chip-Seq_HEK293_Human1.36638715
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35863265
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.35728979
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.35276513
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.34603973
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31525004
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28196437
56AR_21909140_ChIP-Seq_LNCAP_Human1.27958851
57RNF2_27304074_Chip-Seq_NSC_Mouse1.24238046
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24146070
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23709401
60GABP_19822575_ChIP-Seq_HepG2_Human1.23632350
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.21698063
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21632670
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20845542
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20560453
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.20380883
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18760043
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14405003
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.13152783
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.10780675
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08988367
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08203755
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07935615
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07131748
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.06246907
75TP53_22573176_ChIP-Seq_HFKS_Human1.05077883
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05060458
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04943150
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.03602188
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03535841
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03524445
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00958084
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00849705
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00593103
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00102816
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98285240
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97304113
87ER_23166858_ChIP-Seq_MCF-7_Human0.96427496
88HTT_18923047_ChIP-ChIP_STHdh_Human0.95139433
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95015480
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94487666
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.92989564
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92342829
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91684762
94REST_21632747_ChIP-Seq_MESCs_Mouse0.90979063
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90753644
96CBP_20019798_ChIP-Seq_JUKART_Human0.90753644
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89123436
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89075212
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86809887
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86608464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.76476440
2MP0000569_abnormal_digit_pigmentation3.50584473
3MP0002102_abnormal_ear_morphology3.00431518
4MP0003693_abnormal_embryo_hatching2.91458937
5MP0006072_abnormal_retinal_apoptosis2.75943607
6MP0001529_abnormal_vocalization2.54659054
7MP0000049_abnormal_middle_ear2.43542007
8MP0003567_abnormal_fetal_cardiomyocyte2.40703642
9MP0008058_abnormal_DNA_repair2.26127977
10MP0010094_abnormal_chromosome_stability2.21732875
11MP0008877_abnormal_DNA_methylation2.14266248
12MP0006292_abnormal_olfactory_placode2.00847023
13MP0002234_abnormal_pharynx_morphology1.91517147
14MP0005646_abnormal_pituitary_gland1.90363845
15MP0001485_abnormal_pinna_reflex1.83091115
16MP0002938_white_spotting1.82432948
17MP0010030_abnormal_orbit_morphology1.80479547
18MP0003880_abnormal_central_pattern1.71978947
19MP0008789_abnormal_olfactory_epithelium1.69957758
20MP0005084_abnormal_gallbladder_morpholo1.66907719
21MP0004957_abnormal_blastocyst_morpholog1.66837622
22MP0002736_abnormal_nociception_after1.63409362
23MP0001293_anophthalmia1.60729589
24MP0003937_abnormal_limbs/digits/tail_de1.59425320
25MP0003315_abnormal_perineum_morphology1.58390131
26MP0001968_abnormal_touch/_nociception1.54846201
27MP0002822_catalepsy1.54425732
28MP0009046_muscle_twitch1.54261960
29MP0002272_abnormal_nervous_system1.52922630
30MP0001905_abnormal_dopamine_level1.51607087
31MP0005253_abnormal_eye_physiology1.48752709
32MP0009745_abnormal_behavioral_response1.43664728
33MP0008932_abnormal_embryonic_tissue1.42475512
34MP0003111_abnormal_nucleus_morphology1.40992004
35MP0004742_abnormal_vestibular_system1.38121572
36MP0003119_abnormal_digestive_system1.37796025
37MP0003718_maternal_effect1.37642348
38MP0002735_abnormal_chemical_nociception1.36882304
39MP0003938_abnormal_ear_development1.36741870
40MP0003136_yellow_coat_color1.35562165
41MP0003806_abnormal_nucleotide_metabolis1.35448239
42MP0001346_abnormal_lacrimal_gland1.34327586
43MP0002751_abnormal_autonomic_nervous1.33901052
44MP0003077_abnormal_cell_cycle1.31905813
45MP0005394_taste/olfaction_phenotype1.31367221
46MP0005499_abnormal_olfactory_system1.31367221
47MP0003121_genomic_imprinting1.26268499
48MP0004142_abnormal_muscle_tone1.24580683
49MP0002210_abnormal_sex_determination1.22652561
50MP0003122_maternal_imprinting1.22304358
51MP0000778_abnormal_nervous_system1.21563605
52MP0008995_early_reproductive_senescence1.19649145
53MP0004133_heterotaxia1.15973102
54MP0005423_abnormal_somatic_nervous1.14923117
55MP0003890_abnormal_embryonic-extraembry1.14381754
56MP0009697_abnormal_copulation1.14357495
57MP0004885_abnormal_endolymph1.13565468
58MP0000631_abnormal_neuroendocrine_gland1.12927325
59MP0002233_abnormal_nose_morphology1.10253205
60MP0006276_abnormal_autonomic_nervous1.09870586
61MP0000026_abnormal_inner_ear1.08260714
62MP0002572_abnormal_emotion/affect_behav1.07518677
63MP0005551_abnormal_eye_electrophysiolog1.06967650
64MP0003186_abnormal_redox_activity1.06687939
65MP0008007_abnormal_cellular_replicative1.06360335
66MP0001486_abnormal_startle_reflex1.04107015
67MP0005171_absent_coat_pigmentation0.99894115
68MP0002557_abnormal_social/conspecific_i0.94107482
69MP0006035_abnormal_mitochondrial_morpho0.93949843
70MP0002282_abnormal_trachea_morphology0.93822464
71MP0003635_abnormal_synaptic_transmissio0.92859699
72MP0002733_abnormal_thermal_nociception0.91679743
73MP0005187_abnormal_penis_morphology0.91575533
74MP0002163_abnormal_gland_morphology0.91352692
75MP0005391_vision/eye_phenotype0.90668029
76MP0000653_abnormal_sex_gland0.89649829
77MP0001929_abnormal_gametogenesis0.89570470
78MP0002067_abnormal_sensory_capabilities0.89010720
79MP0001188_hyperpigmentation0.88826826
80MP0002752_abnormal_somatic_nervous0.88076334
81MP0000372_irregular_coat_pigmentation0.87318218
82MP0001145_abnormal_male_reproductive0.84243943
83MP0004147_increased_porphyrin_level0.83862800
84MP0002064_seizures0.83152375
85MP0005195_abnormal_posterior_eye0.82799496
86MP0003861_abnormal_nervous_system0.81206759
87MP0003787_abnormal_imprinting0.81100574
88MP0001119_abnormal_female_reproductive0.80932316
89MP0002277_abnormal_respiratory_mucosa0.80857336
90MP0002638_abnormal_pupillary_reflex0.79873837
91MP0001286_abnormal_eye_development0.78784443
92MP0001963_abnormal_hearing_physiology0.77323723
93MP0002184_abnormal_innervation0.76969157
94MP0003786_premature_aging0.75946485
95MP0002734_abnormal_mechanical_nocicepti0.75683759
96MP0004924_abnormal_behavior0.75631257
97MP0005386_behavior/neurological_phenoty0.75631257
98MP0000516_abnormal_urinary_system0.74789675
99MP0005367_renal/urinary_system_phenotyp0.74789675
100MP0006036_abnormal_mitochondrial_physio0.72905220

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.74251419
2Reticulocytopenia (HP:0001896)4.47718191
3Abnormal mitochondria in muscle tissue (HP:0008316)4.32056089
4Acute encephalopathy (HP:0006846)4.27924365
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.19240812
6Meckel diverticulum (HP:0002245)4.08441972
7Abnormality of the labia minora (HP:0012880)4.00542585
8Abnormality of the ileum (HP:0001549)3.94490904
9Progressive macrocephaly (HP:0004481)3.84921133
10Mitochondrial inheritance (HP:0001427)3.83044059
11Chromsome breakage (HP:0040012)3.79583079
12Increased CSF lactate (HP:0002490)3.56263923
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.43388302
14Duplicated collecting system (HP:0000081)3.20219001
15Abnormality of the renal collecting system (HP:0004742)3.15710939
16Increased hepatocellular lipid droplets (HP:0006565)3.14492415
17Hepatocellular necrosis (HP:0001404)3.13165022
18Hepatic necrosis (HP:0002605)2.94249198
19Abnormality of the preputium (HP:0100587)2.93229251
20Small intestinal stenosis (HP:0012848)2.93113921
21Duodenal stenosis (HP:0100867)2.93113921
22Hyperglycinemia (HP:0002154)2.92555233
23Lipid accumulation in hepatocytes (HP:0006561)2.90093326
24Cerebral edema (HP:0002181)2.88421215
25Pancreatic cysts (HP:0001737)2.78808030
26True hermaphroditism (HP:0010459)2.73371214
27Congenital stationary night blindness (HP:0007642)2.72704674
28Abnormality of chromosome stability (HP:0003220)2.70579192
29Abnormal lung lobation (HP:0002101)2.69833179
30Intestinal atresia (HP:0011100)2.67363313
31Horseshoe kidney (HP:0000085)2.66410138
32Molar tooth sign on MRI (HP:0002419)2.60224426
33Abnormality of midbrain morphology (HP:0002418)2.60224426
34Optic disc pallor (HP:0000543)2.58985014
35Limb dystonia (HP:0002451)2.55251016
36Pancreatic fibrosis (HP:0100732)2.50926038
37Supernumerary spleens (HP:0009799)2.49811314
38Absent thumb (HP:0009777)2.46510530
39Congenital, generalized hypertrichosis (HP:0004540)2.45369199
40Abnormality of the duodenum (HP:0002246)2.45340583
41Renal Fanconi syndrome (HP:0001994)2.44425975
42Clubbing of toes (HP:0100760)2.42852716
43Hypoplasia of the pons (HP:0012110)2.33929510
44Triphalangeal thumb (HP:0001199)2.31969210
45Ectopic kidney (HP:0000086)2.31131521
46Aplasia involving forearm bones (HP:0009822)2.29729015
47Absent forearm bone (HP:0003953)2.29729015
48Absent radius (HP:0003974)2.25489970
49Nephronophthisis (HP:0000090)2.25399189
50Leukodystrophy (HP:0002415)2.23035652
51Abnormality of the carotid arteries (HP:0005344)2.18362335
52Septo-optic dysplasia (HP:0100842)2.14926330
53Increased serum pyruvate (HP:0003542)2.14092572
54Abnormality of the pons (HP:0007361)2.12904418
55Patellar aplasia (HP:0006443)2.12179232
56Humeroradial synostosis (HP:0003041)2.08443482
57Synostosis involving the elbow (HP:0003938)2.08443482
58Increased serum lactate (HP:0002151)2.06744895
59Aplasia/Hypoplasia of the patella (HP:0006498)2.05922390
60Absent septum pellucidum (HP:0001331)2.02849752
61Respiratory failure (HP:0002878)2.02436993
62Lactic acidosis (HP:0003128)2.00349841
63Pancytopenia (HP:0001876)1.99096004
64Colon cancer (HP:0003003)1.97458367
65Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96638866
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96638866
67Abnormality of DNA repair (HP:0003254)1.95453676
68Pendular nystagmus (HP:0012043)1.95154557
69Exercise intolerance (HP:0003546)1.91743768
70Inability to walk (HP:0002540)1.88740781
71Symphalangism affecting the phalanges of the hand (HP:0009773)1.88177110
72Abnormality of glycolysis (HP:0004366)1.86437379
73Abnormal biliary tract physiology (HP:0012439)1.83432411
74Bile duct proliferation (HP:0001408)1.83432411
75Medial flaring of the eyebrow (HP:0010747)1.82132855
76Exertional dyspnea (HP:0002875)1.81845745
77Cortical dysplasia (HP:0002539)1.81544585
78Bilateral microphthalmos (HP:0007633)1.78931784
79Short thumb (HP:0009778)1.78085382
80Anencephaly (HP:0002323)1.77588453
81Hyperglycinuria (HP:0003108)1.76610660
82Sloping forehead (HP:0000340)1.75874913
83Methylmalonic acidemia (HP:0002912)1.74896645
84Birth length less than 3rd percentile (HP:0003561)1.74413209
85Stenosis of the external auditory canal (HP:0000402)1.74063820
86Abnormality of glycine metabolism (HP:0010895)1.72459867
87Abnormality of serine family amino acid metabolism (HP:0010894)1.72459867
88Aplasia/hypoplasia of the uterus (HP:0008684)1.71451034
89Abnormality of the septum pellucidum (HP:0007375)1.70401823
90Increased intramyocellular lipid droplets (HP:0012240)1.70102331
91X-linked dominant inheritance (HP:0001423)1.70001311
92Abnormality of the renal medulla (HP:0100957)1.69295728
93Abolished electroretinogram (ERG) (HP:0000550)1.68607954
94Aganglionic megacolon (HP:0002251)1.65657072
95Methylmalonic aciduria (HP:0012120)1.64328889
96Postaxial foot polydactyly (HP:0001830)1.64201053
97Oligodactyly (hands) (HP:0001180)1.63922259
98Carpal bone hypoplasia (HP:0001498)1.63573457
99Pallor (HP:0000980)1.63240961
100Aplasia/Hypoplasia involving the musculature (HP:0001460)1.62688589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.15787801
2MAP4K23.30554272
3BUB12.98370763
4VRK12.94884658
5SRPK12.68446574
6ZAK2.45430530
7TAF12.43070506
8GRK12.41576184
9PNCK2.32641887
10DYRK22.18884269
11WEE12.18216732
12PLK32.14546471
13WNK32.09407599
14CDC72.04804712
15TSSK62.04270615
16TIE11.94104822
17BCR1.89069110
18TRIM281.88112232
19NUAK11.87028320
20MKNK21.83104140
21PLK41.81910443
22NME11.72259380
23PINK11.70381859
24STK161.69127865
25ADRBK21.67391241
26MARK11.65785819
27MKNK11.62947838
28CSNK1G31.50861574
29CCNB11.47290801
30INSRR1.46559811
31CSNK1G11.46324018
32BCKDK1.41848195
33TAOK31.40298733
34CSNK1G21.30457801
35BRSK21.25829457
36DYRK31.22520030
37NEK11.21053431
38PRKCG1.17879641
39MINK11.17394390
40TTK1.14093810
41TESK11.09888802
42EIF2AK31.04712214
43ERBB31.01963547
44PLK10.98533135
45MAPK150.98500611
46CSNK1A1L0.95956173
47MST40.92456490
48CHEK20.90874991
49AURKB0.87351711
50DAPK10.85745621
51BMPR1B0.85640407
52MAP3K40.84311281
53PLK20.81870729
54TLK10.78532283
55TNIK0.76884614
56BRSK10.75709162
57ATR0.74439173
58PDK20.72085715
59RPS6KA40.67084937
60RPS6KA50.67081815
61DYRK1A0.64817678
62CSNK1A10.63799922
63CDK190.63780722
64PASK0.62935512
65PBK0.59370013
66OXSR10.59024848
67KIT0.58266561
68AURKA0.57304696
69EIF2AK20.56967323
70STK390.55101074
71MAPKAPK50.52642489
72PRKCQ0.51021064
73FRK0.49357250
74MAPK130.47961857
75ADRBK10.47023965
76GRK50.46072805
77CASK0.44466803
78CSNK1E0.44408534
79CSNK2A10.43770969
80CSNK2A20.43008777
81EPHB20.42012379
82MAP2K70.41741286
83PRKG10.41357986
84ATM0.39470601
85EPHA40.39134391
86EIF2AK10.37572977
87PRKACB0.37042473
88CHEK10.37022533
89CDK140.36429995
90TGFBR10.35316633
91PAK30.34864982
92DAPK30.34810531
93PRKCE0.34612681
94NEK20.33858672
95CDK80.33707489
96PRKACA0.31818501
97WNK40.31183418
98CDK70.30616958
99PHKG20.30490622
100PHKG10.30490622

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.59594761
2Ribosome_Homo sapiens_hsa030103.43139992
3Oxidative phosphorylation_Homo sapiens_hsa001903.32110158
4Parkinsons disease_Homo sapiens_hsa050123.10472120
5RNA polymerase_Homo sapiens_hsa030202.97151299
6DNA replication_Homo sapiens_hsa030302.78745926
7Mismatch repair_Homo sapiens_hsa034302.74948930
8Fanconi anemia pathway_Homo sapiens_hsa034602.66612768
9Homologous recombination_Homo sapiens_hsa034402.63954482
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.55758902
11Protein export_Homo sapiens_hsa030602.32218895
12Huntingtons disease_Homo sapiens_hsa050162.27697578
13RNA degradation_Homo sapiens_hsa030182.20248391
14Spliceosome_Homo sapiens_hsa030402.03416130
15Alzheimers disease_Homo sapiens_hsa050101.91137548
16Non-homologous end-joining_Homo sapiens_hsa034501.90970899
17Base excision repair_Homo sapiens_hsa034101.81354606
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81227061
19Basal transcription factors_Homo sapiens_hsa030221.79312460
20Steroid biosynthesis_Homo sapiens_hsa001001.77079943
21RNA transport_Homo sapiens_hsa030131.76839078
22Cardiac muscle contraction_Homo sapiens_hsa042601.67570219
23Nicotine addiction_Homo sapiens_hsa050331.60892274
24Nucleotide excision repair_Homo sapiens_hsa034201.57846774
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56556913
26Pyrimidine metabolism_Homo sapiens_hsa002401.49322259
27One carbon pool by folate_Homo sapiens_hsa006701.46876548
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45598355
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45327883
30Propanoate metabolism_Homo sapiens_hsa006401.44101922
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38532787
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28374053
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27806106
34Phototransduction_Homo sapiens_hsa047441.25906576
35Cell cycle_Homo sapiens_hsa041101.24041302
36Purine metabolism_Homo sapiens_hsa002301.20688226
37Folate biosynthesis_Homo sapiens_hsa007901.20201690
38Systemic lupus erythematosus_Homo sapiens_hsa053221.16185081
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15923128
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14342115
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04555831
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04524793
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95453579
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90567592
45Oocyte meiosis_Homo sapiens_hsa041140.85626026
46Basal cell carcinoma_Homo sapiens_hsa052170.83725826
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81003314
48Butanoate metabolism_Homo sapiens_hsa006500.79467893
49Peroxisome_Homo sapiens_hsa041460.76302054
50Taste transduction_Homo sapiens_hsa047420.75945313
51Pyruvate metabolism_Homo sapiens_hsa006200.75675133
52Alcoholism_Homo sapiens_hsa050340.73984676
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.73608134
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73577659
55Sulfur relay system_Homo sapiens_hsa041220.71512947
56Fatty acid elongation_Homo sapiens_hsa000620.70268370
57beta-Alanine metabolism_Homo sapiens_hsa004100.68872105
58Hedgehog signaling pathway_Homo sapiens_hsa043400.67254055
59mRNA surveillance pathway_Homo sapiens_hsa030150.66845592
60Metabolic pathways_Homo sapiens_hsa011000.65963847
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64040054
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56920862
63Nitrogen metabolism_Homo sapiens_hsa009100.55368164
64Chemical carcinogenesis_Homo sapiens_hsa052040.53223706
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53091742
66p53 signaling pathway_Homo sapiens_hsa041150.52657879
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48743590
68Tryptophan metabolism_Homo sapiens_hsa003800.48711888
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48620478
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48527015
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47773433
72Linoleic acid metabolism_Homo sapiens_hsa005910.47437524
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46168291
74Caffeine metabolism_Homo sapiens_hsa002320.45403722
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45079749
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43685171
77Primary immunodeficiency_Homo sapiens_hsa053400.42592045
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42525818
79GABAergic synapse_Homo sapiens_hsa047270.41855632
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.41795119
81Olfactory transduction_Homo sapiens_hsa047400.41777255
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.41545829
83Glutathione metabolism_Homo sapiens_hsa004800.40959899
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.39487877
85Epstein-Barr virus infection_Homo sapiens_hsa051690.35120471
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.34796650
87Carbon metabolism_Homo sapiens_hsa012000.34034078
88Collecting duct acid secretion_Homo sapiens_hsa049660.31408196
89Retinol metabolism_Homo sapiens_hsa008300.31005924
90Biosynthesis of amino acids_Homo sapiens_hsa012300.30534333
91Glutamatergic synapse_Homo sapiens_hsa047240.30164945
92Regulation of autophagy_Homo sapiens_hsa041400.29707591
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27859048
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27672719
95Arginine and proline metabolism_Homo sapiens_hsa003300.27130193
96Wnt signaling pathway_Homo sapiens_hsa043100.26096514
97Dorso-ventral axis formation_Homo sapiens_hsa043200.24917293
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23306077
99Vitamin digestion and absorption_Homo sapiens_hsa049770.20807838
100Selenocompound metabolism_Homo sapiens_hsa004500.20181463

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