TUBBP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.53265771
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.45028798
3DNA double-strand break processing (GO:0000729)5.10109553
4chromatin remodeling at centromere (GO:0031055)4.98407593
5CENP-A containing nucleosome assembly (GO:0034080)4.95653587
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.85206554
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.74611187
8mitotic metaphase plate congression (GO:0007080)4.50932943
9protein localization to chromosome, centromeric region (GO:0071459)4.50075858
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.43125188
11ATP synthesis coupled proton transport (GO:0015986)4.43125188
12metaphase plate congression (GO:0051310)4.41380233
13DNA catabolic process, exonucleolytic (GO:0000738)4.40431161
14chaperone-mediated protein transport (GO:0072321)4.31518969
15protein K6-linked ubiquitination (GO:0085020)4.28136143
16mitotic sister chromatid segregation (GO:0000070)4.24387000
17cullin deneddylation (GO:0010388)4.20784112
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.17924647
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.17924647
20NADH dehydrogenase complex assembly (GO:0010257)4.17924647
21microtubule depolymerization (GO:0007019)4.13080437
22protein deneddylation (GO:0000338)4.08585006
23histone exchange (GO:0043486)4.00945777
24sister chromatid segregation (GO:0000819)3.90994135
25establishment of chromosome localization (GO:0051303)3.83808869
26protein-cofactor linkage (GO:0018065)3.76765905
27DNA replication-independent nucleosome assembly (GO:0006336)3.75577431
28DNA replication-independent nucleosome organization (GO:0034724)3.75577431
29attachment of spindle microtubules to kinetochore (GO:0008608)3.71744406
30regulation of DNA endoreduplication (GO:0032875)3.70837152
31DNA replication checkpoint (GO:0000076)3.70562079
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.69161422
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69016729
34protein complex biogenesis (GO:0070271)3.68340368
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67681329
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60443578
37protein neddylation (GO:0045116)3.60414569
38protein localization to chromosome (GO:0034502)3.59461660
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59338221
40spindle checkpoint (GO:0031577)3.58800669
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53280185
42mitochondrial respiratory chain complex assembly (GO:0033108)3.51099900
43sequestering of actin monomers (GO:0042989)3.50318820
44organelle disassembly (GO:1903008)3.50050131
45DNA strand renaturation (GO:0000733)3.46364879
46telomere maintenance via semi-conservative replication (GO:0032201)3.45394159
47maturation of 5.8S rRNA (GO:0000460)3.41905263
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.38878367
49replication fork processing (GO:0031297)3.37338541
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.33110059
51DNA ligation (GO:0006266)3.31578466
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27530213
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22463837
54negative regulation of ligase activity (GO:0051352)3.22463837
55DNA strand elongation involved in DNA replication (GO:0006271)3.21091091
56mitotic spindle checkpoint (GO:0071174)3.19512867
57proteasome assembly (GO:0043248)3.17864317
58resolution of meiotic recombination intermediates (GO:0000712)3.09591145
59DNA deamination (GO:0045006)3.08632084
60postreplication repair (GO:0006301)3.08261562
61regulation of mitotic spindle checkpoint (GO:1903504)3.06908620
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06908620
63DNA strand elongation (GO:0022616)3.02505599
64rRNA modification (GO:0000154)3.02490857
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01213331
66respiratory electron transport chain (GO:0022904)2.99186028
67telomere maintenance via recombination (GO:0000722)2.98678343
68negative regulation of chromosome segregation (GO:0051985)2.98436048
69telomere maintenance via telomere lengthening (GO:0010833)2.98144697
70ribosome assembly (GO:0042255)2.97637288
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96821995
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96821995
73negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96821995
74negative regulation of mitotic sister chromatid separation (GO:2000816)2.96821995
75negative regulation of sister chromatid segregation (GO:0033046)2.96821995
76termination of RNA polymerase I transcription (GO:0006363)2.96816564
77microtubule polymerization or depolymerization (GO:0031109)2.96315351
78mitotic recombination (GO:0006312)2.95600618
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93244173
80ribonucleoprotein complex disassembly (GO:0032988)2.93165025
81meiotic chromosome segregation (GO:0045132)2.91669463
82electron transport chain (GO:0022900)2.91365403
83regulation of sister chromatid cohesion (GO:0007063)2.89837572
84recombinational repair (GO:0000725)2.89720598
85spindle assembly checkpoint (GO:0071173)2.88438993
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88415494
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88415494
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88415494
89chromosome segregation (GO:0007059)2.88085142
90negative regulation of DNA recombination (GO:0045910)2.87402595
91regulation of chromosome segregation (GO:0051983)2.86489951
92inner mitochondrial membrane organization (GO:0007007)2.85856790
93mitotic spindle assembly checkpoint (GO:0007094)2.85283006
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85177013
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85177013
96double-strand break repair via homologous recombination (GO:0000724)2.83938989
97somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83284257
98somatic hypermutation of immunoglobulin genes (GO:0016446)2.83284257
99nucleotide-excision repair, DNA gap filling (GO:0006297)2.82984336
100spliceosomal snRNP assembly (GO:0000387)2.82583098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.99520047
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.13081380
3E2F7_22180533_ChIP-Seq_HELA_Human4.52131269
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.15783526
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06680192
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.03180177
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.60337138
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.35777183
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14396874
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09373168
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79300793
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.60840561
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60341917
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51588917
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47679691
16ELK1_19687146_ChIP-ChIP_HELA_Human2.46698604
17VDR_22108803_ChIP-Seq_LS180_Human2.45406768
18VDR_23849224_ChIP-Seq_CD4+_Human2.38644925
19ZNF274_21170338_ChIP-Seq_K562_Hela2.29401257
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.18843843
21FOXP3_21729870_ChIP-Seq_TREG_Human2.14450484
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14330523
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00956744
24TAF15_26573619_Chip-Seq_HEK293_Human1.97041713
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94985362
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.86345046
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85984886
28EWS_26573619_Chip-Seq_HEK293_Human1.84237765
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79489543
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73723630
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68573415
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.68136115
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63793136
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.61961531
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61362086
36MYC_18940864_ChIP-ChIP_HL60_Human1.59179293
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57645457
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55594807
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.53273735
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53168769
41AR_21909140_ChIP-Seq_LNCAP_Human1.50739137
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50426368
43TTF2_22483619_ChIP-Seq_HELA_Human1.47009518
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44261264
45GABP_19822575_ChIP-Seq_HepG2_Human1.43491758
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40921151
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39897730
48DCP1A_22483619_ChIP-Seq_HELA_Human1.39534233
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37574666
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.36047174
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35735286
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32042116
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26358247
54FUS_26573619_Chip-Seq_HEK293_Human1.25794737
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24367393
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24269881
57XRN2_22483619_ChIP-Seq_HELA_Human1.23828682
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22435477
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21328591
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20703028
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19893519
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18441070
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16922841
64IGF1R_20145208_ChIP-Seq_DFB_Human1.16246816
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10767022
66P300_19829295_ChIP-Seq_ESCs_Human1.09038316
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06698097
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05364120
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04821100
70ER_23166858_ChIP-Seq_MCF-7_Human1.03458373
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.03385840
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01888196
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.00868932
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97927368
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.97655878
76RNF2_27304074_Chip-Seq_NSC_Mouse0.96000872
77EZH2_22144423_ChIP-Seq_EOC_Human0.94554991
78NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88624921
79TP53_22573176_ChIP-Seq_HFKS_Human0.87478531
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87042569
81IRF1_19129219_ChIP-ChIP_H3396_Human0.85819076
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84417525
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82951197
84SOX2_19829295_ChIP-Seq_ESCs_Human0.82525859
85NANOG_19829295_ChIP-Seq_ESCs_Human0.82525859
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81497368
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.80371596
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78607423
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77917509
90HTT_18923047_ChIP-ChIP_STHdh_Human0.77547669
91GBX2_23144817_ChIP-Seq_PC3_Human0.75365431
92AR_20517297_ChIP-Seq_VCAP_Human0.75319584
93CIITA_25753668_ChIP-Seq_RAJI_Human0.73763356
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73613977
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73201532
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.72929921
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.70365302
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.70048118
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69991454
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69716910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.27015944
2MP0003693_abnormal_embryo_hatching4.26518036
3MP0010094_abnormal_chromosome_stability3.90067169
4MP0008058_abnormal_DNA_repair3.30986884
5MP0004957_abnormal_blastocyst_morpholog3.16953892
6MP0006072_abnormal_retinal_apoptosis2.92476630
7MP0002653_abnormal_ependyma_morphology2.88034491
8MP0001529_abnormal_vocalization2.60971408
9MP0003077_abnormal_cell_cycle2.51201523
10MP0003718_maternal_effect2.50899492
11MP0001346_abnormal_lacrimal_gland2.42676101
12MP0008995_early_reproductive_senescence2.35635229
13MP0001188_hyperpigmentation2.30719245
14MP0008057_abnormal_DNA_replication2.29544111
15MP0008932_abnormal_embryonic_tissue2.29222015
16MP0004133_heterotaxia2.28678259
17MP0005084_abnormal_gallbladder_morpholo2.27101205
18MP0003111_abnormal_nucleus_morphology2.17022757
19MP0008877_abnormal_DNA_methylation2.16072483
20MP0006292_abnormal_olfactory_placode2.15460767
21MP0005253_abnormal_eye_physiology2.03711123
22MP0003011_delayed_dark_adaptation2.02192928
23MP0006035_abnormal_mitochondrial_morpho1.82295778
24MP0008789_abnormal_olfactory_epithelium1.81320929
25MP0003786_premature_aging1.76678213
26MP0005248_abnormal_Harderian_gland1.52691371
27MP0002138_abnormal_hepatobiliary_system1.48152599
28MP0004147_increased_porphyrin_level1.47370097
29MP0005394_taste/olfaction_phenotype1.44913198
30MP0005499_abnormal_olfactory_system1.44913198
31MP0006036_abnormal_mitochondrial_physio1.44735212
32MP0001984_abnormal_olfaction1.44490034
33MP0000631_abnormal_neuroendocrine_gland1.43569708
34MP0003121_genomic_imprinting1.42332298
35MP0008007_abnormal_cellular_replicative1.34518865
36MP0001986_abnormal_taste_sensitivity1.33067893
37MP0005645_abnormal_hypothalamus_physiol1.27810685
38MP0008875_abnormal_xenobiotic_pharmacok1.25388658
39MP0000372_irregular_coat_pigmentation1.24365365
40MP0009697_abnormal_copulation1.23187276
41MP0002277_abnormal_respiratory_mucosa1.20863438
42MP0002210_abnormal_sex_determination1.19037044
43MP0003122_maternal_imprinting1.15582800
44MP0001929_abnormal_gametogenesis1.15060654
45MP0005167_abnormal_blood-brain_barrier1.15033420
46MP0005551_abnormal_eye_electrophysiolog1.14214009
47MP0002938_white_spotting1.09886960
48MP0003880_abnormal_central_pattern1.08973949
49MP0004145_abnormal_muscle_electrophysio1.08413479
50MP0003195_calcinosis1.08158744
51MP0002234_abnormal_pharynx_morphology1.07927863
52MP0002233_abnormal_nose_morphology1.06537269
53MP0002928_abnormal_bile_duct1.06524349
54MP0000049_abnormal_middle_ear1.06333856
55MP0001486_abnormal_startle_reflex1.06192915
56MP0001286_abnormal_eye_development1.04776055
57MP0001697_abnormal_embryo_size0.98691607
58MP0000026_abnormal_inner_ear0.98346300
59MP0002736_abnormal_nociception_after0.98109639
60MP0003937_abnormal_limbs/digits/tail_de0.98077487
61MP0004215_abnormal_myocardial_fiber0.97408330
62MP0000653_abnormal_sex_gland0.96077692
63MP0003186_abnormal_redox_activity0.95863831
64MP0003567_abnormal_fetal_cardiomyocyte0.95548585
65MP0001919_abnormal_reproductive_system0.94242447
66MP0002751_abnormal_autonomic_nervous0.93604874
67MP0005391_vision/eye_phenotype0.92660171
68MP0001293_anophthalmia0.92503464
69MP0003646_muscle_fatigue0.92025061
70MP0000566_synostosis0.90998729
71MP0001145_abnormal_male_reproductive0.90245067
72MP0000647_abnormal_sebaceous_gland0.89894028
73MP0003938_abnormal_ear_development0.89770265
74MP0001119_abnormal_female_reproductive0.89711604
75MP0004084_abnormal_cardiac_muscle0.87922819
76MP0009745_abnormal_behavioral_response0.87391789
77MP0001764_abnormal_homeostasis0.86583937
78MP0002272_abnormal_nervous_system0.83925098
79MP0006054_spinal_hemorrhage0.83246200
80MP0000778_abnormal_nervous_system0.80196081
81MP0003119_abnormal_digestive_system0.77914242
82MP0003787_abnormal_imprinting0.77316383
83MP0001324_abnormal_eye_pigmentation0.76876766
84MP0010030_abnormal_orbit_morphology0.75068923
85MP0005195_abnormal_posterior_eye0.74606925
86MP0005389_reproductive_system_phenotype0.74016294
87MP0002752_abnormal_somatic_nervous0.73200629
88MP0003698_abnormal_male_reproductive0.72489891
89MP0004885_abnormal_endolymph0.71390786
90MP0001879_abnormal_lymphatic_vessel0.71014090
91MP0002085_abnormal_embryonic_tissue0.70597959
92MP0005380_embryogenesis_phenotype0.68148939
93MP0001672_abnormal_embryogenesis/_devel0.68148939
94MP0001727_abnormal_embryo_implantation0.67727012
95MP0001963_abnormal_hearing_physiology0.67478363
96MP0005408_hypopigmentation0.67343764
97MP0004142_abnormal_muscle_tone0.64546834
98MP0002638_abnormal_pupillary_reflex0.64010391
99MP0002697_abnormal_eye_size0.63590316
100MP0004043_abnormal_pH_regulation0.63215926

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.76469036
2Abnormal mitochondria in muscle tissue (HP:0008316)3.98446889
3Progressive macrocephaly (HP:0004481)3.87776360
4Acute encephalopathy (HP:0006846)3.86478426
5Mitochondrial inheritance (HP:0001427)3.69109797
6Supernumerary spleens (HP:0009799)3.46592793
7Increased CSF lactate (HP:0002490)3.45911682
8Abnormality of the labia minora (HP:0012880)3.30966165
9Hepatocellular necrosis (HP:0001404)3.30813050
10Cerebral edema (HP:0002181)3.15164233
11Abnormal lung lobation (HP:0002101)3.14406356
12Hepatic necrosis (HP:0002605)2.92097017
13Cortical dysplasia (HP:0002539)2.83835608
14Colon cancer (HP:0003003)2.77744357
15True hermaphroditism (HP:0010459)2.76043545
16Increased serum pyruvate (HP:0003542)2.73693732
17Adrenal hypoplasia (HP:0000835)2.64325413
18Oligodactyly (hands) (HP:0001180)2.62756801
19Meckel diverticulum (HP:0002245)2.57917447
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.57909590
21Small intestinal stenosis (HP:0012848)2.51461588
22Duodenal stenosis (HP:0100867)2.51461588
23Increased hepatocellular lipid droplets (HP:0006565)2.47134088
24Abnormality of the ileum (HP:0001549)2.46554170
25Abnormality of chromosome stability (HP:0003220)2.39133074
26Hypoplasia of the pons (HP:0012110)2.37746211
27Abnormality of the preputium (HP:0100587)2.36681660
28Lipid accumulation in hepatocytes (HP:0006561)2.36153975
29Optic disc pallor (HP:0000543)2.32708500
30Increased serum lactate (HP:0002151)2.31689204
31Absent/shortened dynein arms (HP:0200106)2.31508448
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.31508448
33Abnormality of the duodenum (HP:0002246)2.30163673
34Abnormality of midbrain morphology (HP:0002418)2.30108800
35Molar tooth sign on MRI (HP:0002419)2.30108800
36Abnormality of glycolysis (HP:0004366)2.28279664
37Respiratory failure (HP:0002878)2.28270242
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28118241
39Carpal bone hypoplasia (HP:0001498)2.26547133
40Medial flaring of the eyebrow (HP:0010747)2.23909786
41Nephronophthisis (HP:0000090)2.23290365
42Short tibia (HP:0005736)2.22428637
43Abnormality of the pons (HP:0007361)2.20984237
44Cerebellar dysplasia (HP:0007033)2.20356730
45Clubbing of toes (HP:0100760)2.18833756
46Lactic acidosis (HP:0003128)2.15390284
47Leukodystrophy (HP:0002415)2.14358953
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12550628
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12550628
50Adactyly (HP:0009776)2.09664064
51Reduced antithrombin III activity (HP:0001976)2.07134845
52Combined immunodeficiency (HP:0005387)2.06120643
53Hemivertebrae (HP:0002937)2.05345838
54Type I transferrin isoform profile (HP:0003642)2.01840066
55Sloping forehead (HP:0000340)2.01145487
56Oligodactyly (HP:0012165)1.99526699
57Duplicated collecting system (HP:0000081)1.97889857
58Pancreatic cysts (HP:0001737)1.97416270
59Parakeratosis (HP:0001036)1.97415202
60Aplasia/Hypoplasia of the tibia (HP:0005772)1.97164357
61Pendular nystagmus (HP:0012043)1.96265009
623-Methylglutaconic aciduria (HP:0003535)1.96011102
63Chromsome breakage (HP:0040012)1.95574698
64Methylmalonic acidemia (HP:0002912)1.94344857
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94214782
66Abnormal protein N-linked glycosylation (HP:0012347)1.94214782
67Abnormal protein glycosylation (HP:0012346)1.94214782
68Abnormal glycosylation (HP:0012345)1.94214782
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93288042
70Degeneration of the lateral corticospinal tracts (HP:0002314)1.93288042
71Oral leukoplakia (HP:0002745)1.91540992
72Abnormality of the renal medulla (HP:0100957)1.89569236
73Pancreatic fibrosis (HP:0100732)1.88760507
74Abnormality of the renal collecting system (HP:0004742)1.88745666
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.88445702
76Exercise intolerance (HP:0003546)1.88119110
77Sclerocornea (HP:0000647)1.87838499
78IgG deficiency (HP:0004315)1.86417442
79Methylmalonic aciduria (HP:0012120)1.83610389
80X-linked dominant inheritance (HP:0001423)1.82176904
81Retinal dysplasia (HP:0007973)1.81894534
82Congenital, generalized hypertrichosis (HP:0004540)1.81109479
83Congenital stationary night blindness (HP:0007642)1.80869606
84Horseshoe kidney (HP:0000085)1.80833417
85Severe combined immunodeficiency (HP:0004430)1.80220932
86Abnormal respiratory motile cilium physiology (HP:0012261)1.78616553
87Myelodysplasia (HP:0002863)1.78088348
88Triphalangeal thumb (HP:0001199)1.77922993
89Intestinal atresia (HP:0011100)1.77382348
90Ependymoma (HP:0002888)1.77168239
91Overlapping toe (HP:0001845)1.76220734
92Absent septum pellucidum (HP:0001331)1.75354166
93Pancytopenia (HP:0001876)1.70517140
94Congenital primary aphakia (HP:0007707)1.69115226
95Panhypogammaglobulinemia (HP:0003139)1.67405072
96Aplasia involving forearm bones (HP:0009822)1.67288132
97Absent forearm bone (HP:0003953)1.67288132
98Abnormality of abdominal situs (HP:0011620)1.66800825
99Abdominal situs inversus (HP:0003363)1.66800825
100Irregular epiphyses (HP:0010582)1.66301814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.91021977
2NEK13.89714163
3EIF2AK13.57591723
4EIF2AK33.46601703
5VRK23.41642434
6PBK3.38870464
7TAOK13.19809378
8TAF13.03941890
9SRPK12.70518538
10TSSK62.53443811
11MST42.49325471
12PLK42.41265531
13WNK32.31857438
14NME12.26141059
15WEE12.13897791
16TTK1.87430544
17PLK31.80681774
18MKNK21.79163988
19CCNB11.71587632
20DYRK21.71530886
21NEK21.71038336
22NUAK11.64908988
23TRIM281.63942131
24VRK11.63799218
25BRSK21.61819831
26CDC71.58992423
27MKNK11.55773590
28ZAK1.33470731
29EIF2AK21.33438354
30PINK11.32028877
31TXK1.22943727
32PLK11.22911399
33STK161.16806170
34BCKDK1.15309461
35PASK1.06588309
36CDK31.04274135
37RPS6KA41.03401869
38CDK81.01896847
39AKT30.99326405
40MELK0.99290351
41CSNK1G30.97398158
42ADRBK20.95355482
43AURKB0.94616830
44CSNK1G20.92732859
45DYRK30.92230802
46MINK10.88704608
47TNIK0.88047541
48BCR0.87006815
49CSNK1A1L0.85091497
50PDK20.82007008
51CSNK1G10.77696670
52BRSK10.77405397
53ATR0.77197316
54CHEK20.75891981
55MAP4K20.72218411
56UHMK10.70391092
57STK110.66296399
58PLK20.61426763
59GRK10.60299465
60MAP3K40.56647590
61TIE10.53253339
62NEK90.50219057
63MAPK130.44603154
64GRK60.40311999
65ATM0.38813497
66CDK70.38129796
67CSNK2A10.36154070
68CHEK10.35991697
69STK38L0.35100581
70TGFBR10.34144762
71SGK20.32144567
72PIK3CG0.31817578
73KSR10.30648551
74DAPK10.29917973
75AURKA0.29877808
76CSNK2A20.29014147
77MARK10.28975001
78PHKG10.28885646
79PHKG20.28885646
80CAMKK20.27997375
81CDK40.27919786
82NLK0.27696015
83ERBB30.27180486
84CAMK2A0.27088070
85PRKCG0.25924929
86BMPR1B0.25516346
87CSNK1A10.25383873
88SGK2230.25302391
89SGK4940.25302391
90TEC0.25189793
91STK30.24355932
92BRAF0.23894503
93STK40.23569194
94CSNK1E0.21680763
95CDK140.19710243
96SIK30.19181753
97SGK10.18662616
98ALK0.18571500
99TLK10.17291487
100STK390.16807530

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.94695603
2Mismatch repair_Homo sapiens_hsa034303.41450273
3Protein export_Homo sapiens_hsa030603.27854657
4DNA replication_Homo sapiens_hsa030303.17180097
5Homologous recombination_Homo sapiens_hsa034403.11754622
6Oxidative phosphorylation_Homo sapiens_hsa001903.07905793
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76653599
8Parkinsons disease_Homo sapiens_hsa050122.76016965
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71730108
10Fanconi anemia pathway_Homo sapiens_hsa034602.52418874
11Basal transcription factors_Homo sapiens_hsa030222.41398663
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25629868
13Spliceosome_Homo sapiens_hsa030402.20576874
14Steroid biosynthesis_Homo sapiens_hsa001002.20366507
15Nucleotide excision repair_Homo sapiens_hsa034202.16172852
16RNA degradation_Homo sapiens_hsa030182.16076141
17RNA polymerase_Homo sapiens_hsa030202.15587694
18Base excision repair_Homo sapiens_hsa034102.07705830
19Ribosome_Homo sapiens_hsa030101.94434963
20Non-homologous end-joining_Homo sapiens_hsa034501.94038916
21Huntingtons disease_Homo sapiens_hsa050161.92585559
22Cell cycle_Homo sapiens_hsa041101.92547646
23One carbon pool by folate_Homo sapiens_hsa006701.89945136
24RNA transport_Homo sapiens_hsa030131.81404175
25Alzheimers disease_Homo sapiens_hsa050101.64095327
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62767565
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62584778
28Propanoate metabolism_Homo sapiens_hsa006401.57232238
29Oocyte meiosis_Homo sapiens_hsa041141.40673704
30Pyrimidine metabolism_Homo sapiens_hsa002401.35791705
31Pyruvate metabolism_Homo sapiens_hsa006201.35171605
32Fatty acid elongation_Homo sapiens_hsa000621.27925364
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.25961626
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.22438581
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21262383
36Butanoate metabolism_Homo sapiens_hsa006501.20096477
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17435131
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11551817
39Folate biosynthesis_Homo sapiens_hsa007901.11492041
40Primary immunodeficiency_Homo sapiens_hsa053401.08229463
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04987268
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99572069
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98058238
44Purine metabolism_Homo sapiens_hsa002300.97109342
45Cardiac muscle contraction_Homo sapiens_hsa042600.92479569
46Nicotine addiction_Homo sapiens_hsa050330.89631133
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86771747
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81971010
49p53 signaling pathway_Homo sapiens_hsa041150.80220735
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74333273
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74321193
52mRNA surveillance pathway_Homo sapiens_hsa030150.70051203
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68838786
54Metabolic pathways_Homo sapiens_hsa011000.65564960
55Selenocompound metabolism_Homo sapiens_hsa004500.62291491
56Fatty acid metabolism_Homo sapiens_hsa012120.60501401
57Tryptophan metabolism_Homo sapiens_hsa003800.60238487
58N-Glycan biosynthesis_Homo sapiens_hsa005100.60061753
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58887792
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56696669
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56397633
62Carbon metabolism_Homo sapiens_hsa012000.55986288
63Collecting duct acid secretion_Homo sapiens_hsa049660.53627297
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50734024
65Linoleic acid metabolism_Homo sapiens_hsa005910.49175817
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48690424
67Phototransduction_Homo sapiens_hsa047440.47013926
68Caffeine metabolism_Homo sapiens_hsa002320.45271426
69Peroxisome_Homo sapiens_hsa041460.45078479
70Epstein-Barr virus infection_Homo sapiens_hsa051690.41437276
71Sulfur metabolism_Homo sapiens_hsa009200.41238576
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.39807741
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38563780
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37869936
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37114814
76Glutathione metabolism_Homo sapiens_hsa004800.35747820
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35687080
78Biosynthesis of amino acids_Homo sapiens_hsa012300.35604440
79GABAergic synapse_Homo sapiens_hsa047270.32571731
80Vitamin digestion and absorption_Homo sapiens_hsa049770.31909407
81Retinol metabolism_Homo sapiens_hsa008300.31890705
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.29903254
83Fatty acid degradation_Homo sapiens_hsa000710.28425869
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.26071753
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25566958
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25128307
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.23153315
88Olfactory transduction_Homo sapiens_hsa047400.23017285
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18365954
90Ether lipid metabolism_Homo sapiens_hsa005650.14654530
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13182926
92Fat digestion and absorption_Homo sapiens_hsa049750.12724773
93Viral carcinogenesis_Homo sapiens_hsa052030.11095554
94Chemical carcinogenesis_Homo sapiens_hsa052040.09181270
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.09042655
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08909893
97Morphine addiction_Homo sapiens_hsa050320.07516262
98HTLV-I infection_Homo sapiens_hsa051660.07466575
99Taste transduction_Homo sapiens_hsa047420.07370059
100Serotonergic synapse_Homo sapiens_hsa047260.04636705

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