TUBD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.09381862
2mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.84049743
3mitochondrial respiratory chain complex I assembly (GO:0032981)4.84049743
4NADH dehydrogenase complex assembly (GO:0010257)4.84049743
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63156727
6ATP synthesis coupled proton transport (GO:0015986)4.63156727
7proteasome assembly (GO:0043248)4.40079757
8behavioral response to nicotine (GO:0035095)4.37573315
9fatty acid elongation (GO:0030497)4.10930667
10DNA replication initiation (GO:0006270)3.96525140
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.93472726
12establishment of integrated proviral latency (GO:0075713)3.92240736
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81007057
14regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.78989041
15telomere maintenance via semi-conservative replication (GO:0032201)3.77376692
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75788171
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.75274195
18protoporphyrinogen IX biosynthetic process (GO:0006782)3.69676497
19regulation of cellular amino acid metabolic process (GO:0006521)3.68183778
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64259741
21DNA strand elongation involved in DNA replication (GO:0006271)3.63573447
22maturation of 5.8S rRNA (GO:0000460)3.58595342
23negative regulation of ligase activity (GO:0051352)3.57193535
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57193535
25protein complex biogenesis (GO:0070271)3.52200296
26DNA deamination (GO:0045006)3.47479965
27electron transport chain (GO:0022900)3.46757776
28mitotic metaphase plate congression (GO:0007080)3.46265200
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45309486
30CENP-A containing nucleosome assembly (GO:0034080)3.43546195
31pseudouridine synthesis (GO:0001522)3.42000310
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.39368761
33respiratory electron transport chain (GO:0022904)3.38847653
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.38749599
35telomere maintenance via recombination (GO:0000722)3.36910057
36DNA strand elongation (GO:0022616)3.36196851
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36101198
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36101198
39metaphase plate congression (GO:0051310)3.35714367
40replication fork processing (GO:0031297)3.34471036
41intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33070391
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33070391
43piRNA metabolic process (GO:0034587)3.32305707
44protoporphyrinogen IX metabolic process (GO:0046501)3.31389320
45regulation of centriole replication (GO:0046599)3.30544283
46establishment of chromosome localization (GO:0051303)3.28704515
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28225376
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28225376
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28225376
50fucose catabolic process (GO:0019317)3.28145303
51L-fucose metabolic process (GO:0042354)3.28145303
52L-fucose catabolic process (GO:0042355)3.28145303
53binding of sperm to zona pellucida (GO:0007339)3.26918860
54establishment of viral latency (GO:0019043)3.24643574
55heme biosynthetic process (GO:0006783)3.23441303
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21757665
57kinetochore organization (GO:0051383)3.21555555
58positive regulation of chromosome segregation (GO:0051984)3.20610708
59negative regulation of DNA-dependent DNA replication (GO:2000104)3.19777772
60mitochondrial respiratory chain complex assembly (GO:0033108)3.19739238
61antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19510720
62positive regulation of ligase activity (GO:0051351)3.18990293
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18389330
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.18389330
65respiratory chain complex IV assembly (GO:0008535)3.18231500
66chromatin remodeling at centromere (GO:0031055)3.17204467
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.17117488
68DNA replication checkpoint (GO:0000076)3.13147069
69signal transduction involved in cell cycle checkpoint (GO:0072395)3.12571586
70histone exchange (GO:0043486)3.11915191
71viral mRNA export from host cell nucleus (GO:0046784)3.10088109
72kinetochore assembly (GO:0051382)3.09338066
73recombinational repair (GO:0000725)3.09263369
74amino acid salvage (GO:0043102)3.08952690
75L-methionine salvage (GO:0071267)3.08952690
76L-methionine biosynthetic process (GO:0071265)3.08952690
77DNA ligation (GO:0006266)3.08656596
78mitotic recombination (GO:0006312)3.07859909
79double-strand break repair via homologous recombination (GO:0000724)3.04975333
80water-soluble vitamin biosynthetic process (GO:0042364)3.04946716
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04663675
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04169656
83regulation of ubiquitin-protein transferase activity (GO:0051438)3.03625504
84sperm-egg recognition (GO:0035036)3.02836815
85chaperone-mediated protein transport (GO:0072321)3.02771199
86regulation of ligase activity (GO:0051340)3.02131140
87fusion of sperm to egg plasma membrane (GO:0007342)3.01497754
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01469433
89DNA double-strand break processing (GO:0000729)3.01307260
90formation of translation preinitiation complex (GO:0001731)3.00619518
91DNA replication-dependent nucleosome organization (GO:0034723)3.00304636
92DNA replication-dependent nucleosome assembly (GO:0006335)3.00304636
93oxidative phosphorylation (GO:0006119)2.97725855
94ubiquinone biosynthetic process (GO:0006744)2.97236910
95regulation of exit from mitosis (GO:0007096)2.96084209
96attachment of spindle microtubules to kinetochore (GO:0008608)2.95420447
97microtubule depolymerization (GO:0007019)2.94861092
98peptidyl-histidine modification (GO:0018202)2.94569110
99regulation of cellular amine metabolic process (GO:0033238)2.93663675
100central nervous system myelination (GO:0022010)2.93045822
101axon ensheathment in central nervous system (GO:0032291)2.93045822
102cell cycle G1/S phase transition (GO:0044843)2.91608679
103G1/S transition of mitotic cell cycle (GO:0000082)2.91608679
104epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91513101
105transcription-coupled nucleotide-excision repair (GO:0006283)2.91134972
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.90908297
107somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90908297
108regulation of nuclear cell cycle DNA replication (GO:0033262)2.90643747
1097-methylguanosine RNA capping (GO:0009452)2.90151027
110RNA capping (GO:0036260)2.90151027
111male meiosis (GO:0007140)2.89160686
112ribosomal small subunit biogenesis (GO:0042274)2.88802207
1137-methylguanosine mRNA capping (GO:0006370)2.88239568
114kynurenine metabolic process (GO:0070189)2.87302057
115protein targeting to mitochondrion (GO:0006626)2.86663951
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86646697
117regulation of mitotic spindle checkpoint (GO:1903504)2.86646697
118negative regulation of telomere maintenance (GO:0032205)2.86048127
119RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.85420827
120platelet dense granule organization (GO:0060155)2.85247297
121ubiquinone metabolic process (GO:0006743)2.84095392
122iron-sulfur cluster assembly (GO:0016226)2.81466858
123metallo-sulfur cluster assembly (GO:0031163)2.81466858
124cytochrome complex assembly (GO:0017004)2.80503088
125detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80335111
126reciprocal meiotic recombination (GO:0007131)2.78753063
127reciprocal DNA recombination (GO:0035825)2.78753063
128regulation of centrosome cycle (GO:0046605)2.74270932
129ribosomal small subunit assembly (GO:0000028)2.74222749
130protein-cofactor linkage (GO:0018065)2.71444456
131DNA replication-independent nucleosome organization (GO:0034724)2.70375695
132DNA replication-independent nucleosome assembly (GO:0006336)2.70375695
133signal peptide processing (GO:0006465)2.69535670
134heme metabolic process (GO:0042168)2.67922173
135deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.67652022
136negative regulation of immunoglobulin mediated immune response (GO:0002890)2.67598780
137negative regulation of B cell mediated immunity (GO:0002713)2.67598780
138regulation of spindle organization (GO:0090224)2.65530941
139termination of RNA polymerase III transcription (GO:0006386)2.65399565
140transcription elongation from RNA polymerase III promoter (GO:0006385)2.65399565
141synapsis (GO:0007129)2.65091441
142antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.64382570
143establishment of protein localization to mitochondrion (GO:0072655)2.63989839
144cell-cell recognition (GO:0009988)2.63987098
145ATP biosynthetic process (GO:0006754)2.63640692
146epithelial cilium movement (GO:0003351)2.63382217
147male meiosis I (GO:0007141)2.62879545
148kidney morphogenesis (GO:0060993)2.61821331
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.59504266
150regulation of translation, ncRNA-mediated (GO:0045974)2.59504266
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59504266
152protein K6-linked ubiquitination (GO:0085020)2.57902835
153maturation of SSU-rRNA (GO:0030490)2.57225723
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56608509
155response to pheromone (GO:0019236)2.56365364
156tRNA processing (GO:0008033)2.55714663
157indole-containing compound catabolic process (GO:0042436)2.53287412
158indolalkylamine catabolic process (GO:0046218)2.53287412
159tryptophan catabolic process (GO:0006569)2.53287412
160DNA methylation involved in gamete generation (GO:0043046)2.53282807
161indolalkylamine metabolic process (GO:0006586)2.51629346
162rRNA catabolic process (GO:0016075)2.51495823
163cullin deneddylation (GO:0010388)2.51267186
164protein neddylation (GO:0045116)2.50412554
165mitochondrial RNA metabolic process (GO:0000959)2.50321565
166mannosylation (GO:0097502)2.49419609
167tryptophan metabolic process (GO:0006568)2.48796327
168positive regulation of prostaglandin secretion (GO:0032308)2.46102665
169regulation of centrosome duplication (GO:0010824)2.43813534
170negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40050554
171resolution of meiotic recombination intermediates (GO:0000712)2.40004140
172rRNA modification (GO:0000154)2.38557275
173replicative senescence (GO:0090399)2.38097172
174somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.37675477
175isotype switching (GO:0045190)2.37675477
176somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.37675477
177protein deneddylation (GO:0000338)2.35973971
178DNA catabolic process, exonucleolytic (GO:0000738)2.35394776
179detection of light stimulus involved in visual perception (GO:0050908)2.32617344
180detection of light stimulus involved in sensory perception (GO:0050962)2.32617344
181regulation of mesoderm development (GO:2000380)2.32526242
182nonmotile primary cilium assembly (GO:0035058)2.32162461
183dopamine transport (GO:0015872)2.31383602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.77440275
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10456194
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.93509586
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.79169857
5E2F7_22180533_ChIP-Seq_HELA_Human3.75033625
6ZNF274_21170338_ChIP-Seq_K562_Hela3.61410530
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.49853786
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47576394
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.44175223
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.35780695
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.33656294
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.23158907
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.17761055
14VDR_22108803_ChIP-Seq_LS180_Human3.15663898
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06220035
16* ETS1_20019798_ChIP-Seq_JURKAT_Human3.04144024
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.03858834
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79400414
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.79209332
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67307483
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.65260404
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64261862
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62482889
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58483828
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.49384768
26* VDR_23849224_ChIP-Seq_CD4+_Human2.47938803
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47460008
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40930174
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40591872
30* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39558714
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34398894
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.26097488
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22552231
34* DCP1A_22483619_ChIP-Seq_HELA_Human2.17337401
35ER_23166858_ChIP-Seq_MCF-7_Human2.09466374
36ELK1_19687146_ChIP-ChIP_HELA_Human2.08110386
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06821737
38XRN2_22483619_ChIP-Seq_HELA_Human2.06033337
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03869178
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01923501
41FOXP3_21729870_ChIP-Seq_TREG_Human2.01824501
42HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01574201
43FUS_26573619_Chip-Seq_HEK293_Human1.97289147
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.91358386
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85403504
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85144082
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84973016
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81429405
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79688471
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76884583
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70975919
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69972776
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.68703163
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66532873
55AR_21909140_ChIP-Seq_LNCAP_Human1.62627825
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61707825
57* GABP_19822575_ChIP-Seq_HepG2_Human1.60737577
58P300_19829295_ChIP-Seq_ESCs_Human1.58892304
59* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56834034
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54224230
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49385923
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49223445
63TTF2_22483619_ChIP-Seq_HELA_Human1.48983398
64* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47061968
65GBX2_23144817_ChIP-Seq_PC3_Human1.44740681
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42287674
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39442173
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37802230
69EZH2_22144423_ChIP-Seq_EOC_Human1.36229046
70MYC_18940864_ChIP-ChIP_HL60_Human1.33337955
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32416363
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32185351
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28909402
74KDM5A_27292631_Chip-Seq_BREAST_Human1.27099299
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26632615
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24247190
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.24247190
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18488692
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18308646
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18300883
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18098048
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17615033
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.17513359
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16999746
85CIITA_25753668_ChIP-Seq_RAJI_Human1.16784303
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.15447919
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14981104
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13824543
89IRF1_19129219_ChIP-ChIP_H3396_Human1.13048395
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.12917291
91HOXB7_26014856_ChIP-Seq_BT474_Human1.11892080
92GATA1_22025678_ChIP-Seq_K562_Human1.11516423
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.11463668
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09671210
95SPI1_23547873_ChIP-Seq_NB4_Human1.09570173
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09474582
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09276443
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08967891
99SOX2_19829295_ChIP-Seq_ESCs_Human1.08907640
100NANOG_19829295_ChIP-Seq_ESCs_Human1.08907640
101* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08836718
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08292788
103BCAT_22108803_ChIP-Seq_LS180_Human1.08058954
104RNF2_27304074_Chip-Seq_NSC_Mouse1.07721154
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07040554
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05131381
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04671819
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02001201
109SOX2_16153702_ChIP-ChIP_HESCs_Human1.01630334
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01468698
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01468698
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01179762
113CBP_20019798_ChIP-Seq_JUKART_Human1.00587920
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00587920
115AR_20517297_ChIP-Seq_VCAP_Human1.00454275
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00034011
117* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99925521
118* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99426946
119STAT3_23295773_ChIP-Seq_U87_Human0.99378311
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99170377
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.97986419
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97788602
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97598780
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95998800
125FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95215997
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.95087197
127AR_25329375_ChIP-Seq_VCAP_Human0.94177225
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93625412
129TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93455570
130NCOR_22424771_ChIP-Seq_293T_Human0.93279740
131TCF4_22108803_ChIP-Seq_LS180_Human0.93062388
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92539841
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.92349179
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92028426
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91763186
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91401085
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.90905723
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90806916
139* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89294402
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88144172
141RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87332371
142TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85463893
143HTT_18923047_ChIP-ChIP_STHdh_Human0.85009664
144MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84840019
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84446024
146TAF15_26573619_Chip-Seq_HEK293_Human0.83175620
147CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82565701
148DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81872804
149CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81317561
150SCL_19346495_ChIP-Seq_HPC-7_Human0.81239413
151GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81135816
152HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80448021
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76749377
154* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76540513
155IRF8_21731497_ChIP-ChIP_J774_Mouse0.76490912
156MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75071461
157STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73401127
158* TP53_22573176_ChIP-Seq_HFKS_Human0.72571755
159EWS_26573619_Chip-Seq_HEK293_Human0.70736340
160IGF1R_20145208_ChIP-Seq_DFB_Human0.69266403
161TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68531404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.55032634
2MP0003806_abnormal_nucleotide_metabolis3.92592888
3MP0005410_abnormal_fertilization3.69267176
4MP0003656_abnormal_erythrocyte_physiolo3.64976987
5MP0008057_abnormal_DNA_replication3.55558137
6MP0003693_abnormal_embryo_hatching3.44657238
7MP0008877_abnormal_DNA_methylation2.78961694
8MP0003111_abnormal_nucleus_morphology2.74354591
9MP0001529_abnormal_vocalization2.71504239
10MP0004957_abnormal_blastocyst_morpholog2.58955457
11MP0003195_calcinosis2.47457213
12MP0010094_abnormal_chromosome_stability2.40502626
13MP0006036_abnormal_mitochondrial_physio2.40089379
14MP0001905_abnormal_dopamine_level2.37135003
15MP0003077_abnormal_cell_cycle2.19951375
16MP0008872_abnormal_physiological_respon2.15258607
17MP0000920_abnormal_myelination2.13406497
18MP0005551_abnormal_eye_electrophysiolog2.01926271
19MP0001929_abnormal_gametogenesis1.98635036
20MP0009697_abnormal_copulation1.96188760
21MP0005645_abnormal_hypothalamus_physiol1.92775963
22MP0003136_yellow_coat_color1.89510766
23MP0003718_maternal_effect1.88668226
24MP0006072_abnormal_retinal_apoptosis1.88054978
25MP0000427_abnormal_hair_cycle1.86690215
26MP0001986_abnormal_taste_sensitivity1.80252939
27MP0008007_abnormal_cellular_replicative1.79843697
28MP0005084_abnormal_gallbladder_morpholo1.72744863
29MP0003186_abnormal_redox_activity1.71351062
30MP0001968_abnormal_touch/_nociception1.70713883
31MP0003890_abnormal_embryonic-extraembry1.67298002
32MP0000372_irregular_coat_pigmentation1.63883752
33MP0003329_amyloid_beta_deposits1.61474053
34MP0001293_anophthalmia1.60922453
35MP0005397_hematopoietic_system_phenotyp1.59508097
36MP0001545_abnormal_hematopoietic_system1.59508097
37MP0003763_abnormal_thymus_physiology1.56532242
38MP0008932_abnormal_embryonic_tissue1.56403940
39MP0002396_abnormal_hematopoietic_system1.56205476
40MP0008789_abnormal_olfactory_epithelium1.54838655
41MP0004133_heterotaxia1.53973545
42MP0008058_abnormal_DNA_repair1.53479232
43MP0003787_abnormal_imprinting1.53359185
44MP0005389_reproductive_system_phenotype1.53321261
45MP0003698_abnormal_male_reproductive1.52999038
46MP0008875_abnormal_xenobiotic_pharmacok1.50936024
47MP0002653_abnormal_ependyma_morphology1.49983488
48MP0003011_delayed_dark_adaptation1.47326400
49MP0005253_abnormal_eye_physiology1.47025828
50MP0005408_hypopigmentation1.46984511
51MP0002210_abnormal_sex_determination1.46747709
52MP0009046_muscle_twitch1.46498153
53MP0001919_abnormal_reproductive_system1.43525067
54MP0003123_paternal_imprinting1.43268128
55MP0000569_abnormal_digit_pigmentation1.42901450
56MP0005174_abnormal_tail_pigmentation1.41472744
57MP0004142_abnormal_muscle_tone1.39436247
58MP0000631_abnormal_neuroendocrine_gland1.38464622
59MP0005409_darkened_coat_color1.36696704
60MP0000383_abnormal_hair_follicle1.35178720
61MP0001485_abnormal_pinna_reflex1.35163901
62MP0005075_abnormal_melanosome_morpholog1.33319145
63MP0003786_premature_aging1.29751230
64MP0003937_abnormal_limbs/digits/tail_de1.26873637
65MP0002638_abnormal_pupillary_reflex1.26645874
66MP0003646_muscle_fatigue1.23349916
67MP0005646_abnormal_pituitary_gland1.23319407
68MP0000689_abnormal_spleen_morphology1.22526937
69MP0002163_abnormal_gland_morphology1.19675649
70MP0006054_spinal_hemorrhage1.18921820
71MP0003119_abnormal_digestive_system1.18169553
72MP0009745_abnormal_behavioral_response1.18115515
73MP0005171_absent_coat_pigmentation1.16267841
74MP0001730_embryonic_growth_arrest1.14963258
75MP0005636_abnormal_mineral_homeostasis1.14919231
76MP0009333_abnormal_splenocyte_physiolog1.14626276
77MP0001145_abnormal_male_reproductive1.14112653
78MP0002736_abnormal_nociception_after1.14037076
79MP0001873_stomach_inflammation1.13784336
80MP0009379_abnormal_foot_pigmentation1.11998661
81MP0004885_abnormal_endolymph1.11174188
82MP0002398_abnormal_bone_marrow1.09231553
83MP0004145_abnormal_muscle_electrophysio1.09228742
84MP0000647_abnormal_sebaceous_gland1.08811866
85MP0002837_dystrophic_cardiac_calcinosis1.08060602
86MP0003880_abnormal_central_pattern1.07290766
87MP0002928_abnormal_bile_duct1.07098593
88MP0004808_abnormal_hematopoietic_stem1.06887197
89MP0005464_abnormal_platelet_physiology1.05264867
90MP0002277_abnormal_respiratory_mucosa1.03652438
91MP0002272_abnormal_nervous_system1.03206232
92MP0002876_abnormal_thyroid_physiology1.03187866
93MP0000653_abnormal_sex_gland1.02920264
94MP0003724_increased_susceptibility_to1.02429177
95MP0000747_muscle_weakness1.01523662
96MP0002132_abnormal_respiratory_system0.98627667
97MP0005377_hearing/vestibular/ear_phenot0.97729081
98MP0003878_abnormal_ear_physiology0.97729081
99MP0005499_abnormal_olfactory_system0.97322072
100MP0005394_taste/olfaction_phenotype0.97322072
101MP0002722_abnormal_immune_system0.96843840
102MP0001764_abnormal_homeostasis0.96386510
103MP0002751_abnormal_autonomic_nervous0.94855689
104MP0006276_abnormal_autonomic_nervous0.94717961
105MP0002161_abnormal_fertility/fecundity0.94360257
106MP0003122_maternal_imprinting0.93797187
107MP0006035_abnormal_mitochondrial_morpho0.93086699
108MP0001286_abnormal_eye_development0.92563381
109MP0002102_abnormal_ear_morphology0.92536271
110MP0002938_white_spotting0.92072667
111MP0003567_abnormal_fetal_cardiomyocyte0.91695793
112MP0003936_abnormal_reproductive_system0.91522911
113MP0003121_genomic_imprinting0.91382640
114MP0001727_abnormal_embryo_implantation0.91156895
115MP0002095_abnormal_skin_pigmentation0.90913539
116MP0004742_abnormal_vestibular_system0.87935632
117MP0002429_abnormal_blood_cell0.87886378
118MP0001984_abnormal_olfaction0.87618929
119MP0005195_abnormal_posterior_eye0.87394202
120MP0005058_abnormal_lysosome_morphology0.86065044
121MP0001119_abnormal_female_reproductive0.84602648
122MP0001324_abnormal_eye_pigmentation0.84534241
123MP0002420_abnormal_adaptive_immunity0.83762322
124MP0001819_abnormal_immune_cell0.83628887
125MP0001800_abnormal_humoral_immune0.83370760
126MP0002557_abnormal_social/conspecific_i0.83321004
127MP0005391_vision/eye_phenotype0.82537111
128MP0002723_abnormal_immune_serum0.82068566
129MP0001486_abnormal_startle_reflex0.81358206
130MP0002735_abnormal_chemical_nociception0.81220067
131MP0006292_abnormal_olfactory_placode0.80907342
132MP0004036_abnormal_muscle_relaxation0.80771578
133MP0002160_abnormal_reproductive_system0.80759474
134MP0008873_increased_physiological_sensi0.80648578
135MP0010678_abnormal_skin_adnexa0.80616998
136MP0000716_abnormal_immune_system0.80445782
137MP0000703_abnormal_thymus_morphology0.79986151
138MP0001835_abnormal_antigen_presentation0.79216135
139MP0005584_abnormal_enzyme/coenzyme_acti0.79050693
140MP0010307_abnormal_tumor_latency0.78006610
141MP0000049_abnormal_middle_ear0.77202768
142MP0000350_abnormal_cell_proliferation0.77181261
143MP0003950_abnormal_plasma_membrane0.77002919
144MP0000313_abnormal_cell_death0.76763669
145MP0002148_abnormal_hypersensitivity_rea0.75303740
146MP0000026_abnormal_inner_ear0.75011761
147MP0002067_abnormal_sensory_capabilities0.74084616
148MP0005379_endocrine/exocrine_gland_phen0.73913657
149MP0002184_abnormal_innervation0.73898422
150MP0005266_abnormal_metabolism0.72931222
151MP0003283_abnormal_digestive_organ0.72429352
152MP0002452_abnormal_antigen_presenting0.70933667
153MP0001853_heart_inflammation0.70897463
154MP0001697_abnormal_embryo_size0.70861524
155MP0000015_abnormal_ear_pigmentation0.70298105
156MP0002080_prenatal_lethality0.69783301
157MP0000749_muscle_degeneration0.68227276
158MP0003632_abnormal_nervous_system0.64940636
159MP0002139_abnormal_hepatobiliary_system0.64743714
160MP0000685_abnormal_immune_system0.64704120
161MP0005025_abnormal_response_to0.64533044
162MP0005671_abnormal_response_to0.62737120
163MP0008995_early_reproductive_senescence0.62215574
164MP0000604_amyloidosis0.61584620
165MP0002019_abnormal_tumor_incidence0.61571433

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.61233537
2Abnormality of the heme biosynthetic pathway (HP:0010472)4.59497349
3Pancreatic cysts (HP:0001737)4.27062060
4Mitochondrial inheritance (HP:0001427)4.21402748
5Abnormal mitochondria in muscle tissue (HP:0008316)4.00910285
6Increased hepatocellular lipid droplets (HP:0006565)3.99466125
7Lipid accumulation in hepatocytes (HP:0006561)3.86802222
8Progressive macrocephaly (HP:0004481)3.85793149
9Acute encephalopathy (HP:0006846)3.83810870
10Birth length less than 3rd percentile (HP:0003561)3.81463543
11Hepatocellular necrosis (HP:0001404)3.80666780
12Increased CSF lactate (HP:0002490)3.76544212
13Abnormality of glycolysis (HP:0004366)3.71963262
14Increased serum pyruvate (HP:0003542)3.71963262
15Pancreatic fibrosis (HP:0100732)3.71023182
16Retinal dysplasia (HP:0007973)3.64546313
17Renal Fanconi syndrome (HP:0001994)3.53496778
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.49835280
19True hermaphroditism (HP:0010459)3.43798984
20Nephronophthisis (HP:0000090)3.32580940
21Cerebral hypomyelination (HP:0006808)3.29999201
22Hepatic necrosis (HP:0002605)3.26096181
23Breast hypoplasia (HP:0003187)3.26027380
24Exertional dyspnea (HP:0002875)3.24502152
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22613541
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22613541
27Dynein arm defect of respiratory motile cilia (HP:0012255)3.21706099
28Absent/shortened dynein arms (HP:0200106)3.21706099
29Abnormality of cells of the erythroid lineage (HP:0012130)3.12875608
30Cholecystitis (HP:0001082)3.09519748
31Abnormal gallbladder physiology (HP:0012438)3.09519748
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.06673900
33Abnormal number of erythroid precursors (HP:0012131)3.05393732
34Abnormal respiratory motile cilium morphology (HP:0005938)2.87264651
35Abnormal respiratory epithelium morphology (HP:0012253)2.87264651
36Congenital stationary night blindness (HP:0007642)2.85450172
37Cerebral edema (HP:0002181)2.83922336
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.83013329
39Leukodystrophy (HP:0002415)2.82268541
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.80872382
41Exercise intolerance (HP:0003546)2.80252397
42Respiratory difficulties (HP:0002880)2.79810605
43Type II lissencephaly (HP:0007260)2.78306098
44CNS hypomyelination (HP:0003429)2.76928607
45Reduced antithrombin III activity (HP:0001976)2.76788774
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73143971
47Abnormality of the renal medulla (HP:0100957)2.72622010
48Lactic acidosis (HP:0003128)2.72547149
49Medial flaring of the eyebrow (HP:0010747)2.71787137
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71342838
51Pendular nystagmus (HP:0012043)2.70241759
52Increased serum lactate (HP:0002151)2.69363945
53Tubular atrophy (HP:0000092)2.65124326
54Type I transferrin isoform profile (HP:0003642)2.65028945
55Respiratory failure (HP:0002878)2.62578457
56Meckel diverticulum (HP:0002245)2.61243379
57Abnormality of the renal cortex (HP:0011035)2.60232405
58Abnormality of the ileum (HP:0001549)2.56826311
59Chromsome breakage (HP:0040012)2.56679960
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.55045007
61Concave nail (HP:0001598)2.54152283
62Increased intramyocellular lipid droplets (HP:0012240)2.51297393
63Chronic hepatic failure (HP:0100626)2.51018055
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.47115497
65Abnormal protein N-linked glycosylation (HP:0012347)2.47115497
66Abnormal protein glycosylation (HP:0012346)2.47115497
67Abnormal glycosylation (HP:0012345)2.47115497
68Rhinitis (HP:0012384)2.46197654
69Hypoplasia of the pons (HP:0012110)2.46092964
70Delusions (HP:0000746)2.45539249
71Abnormal respiratory motile cilium physiology (HP:0012261)2.41918651
72Attenuation of retinal blood vessels (HP:0007843)2.41658022
73Hypothermia (HP:0002045)2.41482007
74Peripheral hypomyelination (HP:0007182)2.40792918
753-Methylglutaconic aciduria (HP:0003535)2.39645161
76Cerebral hemorrhage (HP:0001342)2.39550594
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.39520113
78Cystic liver disease (HP:0006706)2.39510412
79Abnormal rod and cone electroretinograms (HP:0008323)2.38823916
80Congenital, generalized hypertrichosis (HP:0004540)2.36892635
81Absent thumb (HP:0009777)2.36174355
82Abnormal biliary tract physiology (HP:0012439)2.35183954
83Bile duct proliferation (HP:0001408)2.35183954
84Sclerocornea (HP:0000647)2.34750215
85Progressive inability to walk (HP:0002505)2.34520205
86IgM deficiency (HP:0002850)2.34142524
87Abnormality of chromosome stability (HP:0003220)2.33812861
88Inability to walk (HP:0002540)2.33803686
89Increased muscle lipid content (HP:0009058)2.33560192
90Patellar aplasia (HP:0006443)2.31041576
91Parakeratosis (HP:0001036)2.30941946
92Abnormality of renal resorption (HP:0011038)2.28475437
93Abolished electroretinogram (ERG) (HP:0000550)2.27874122
94Paralysis (HP:0003470)2.27104565
95Abnormality of the preputium (HP:0100587)2.22543822
96Abnormal ciliary motility (HP:0012262)2.20332267
97Abnormality of the carotid arteries (HP:0005344)2.19651759
98Methylmalonic aciduria (HP:0012120)2.18600730
99Emotional lability (HP:0000712)2.18345722
100Neurofibrillary tangles (HP:0002185)2.16921146
101Aplastic anemia (HP:0001915)2.16833126
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15343489
103Aplasia/Hypoplasia of the patella (HP:0006498)2.15023801
104Abnormality of midbrain morphology (HP:0002418)2.13730380
105Molar tooth sign on MRI (HP:0002419)2.13730380
106Gait imbalance (HP:0002141)2.11956513
107Anencephaly (HP:0002323)2.11365817
108Congenital primary aphakia (HP:0007707)2.08318047
109Abnormality of the labia minora (HP:0012880)2.05560458
110Palpitations (HP:0001962)2.04923031
111Cerebellar dysplasia (HP:0007033)2.02674359
112Recurrent sinusitis (HP:0011108)2.01328453
113Abnormal drinking behavior (HP:0030082)2.01023242
114Polydipsia (HP:0001959)2.01023242
115Furrowed tongue (HP:0000221)2.00388974
116Cutaneous melanoma (HP:0012056)1.99991815
117Unsteady gait (HP:0002317)1.98617131
118Gastrointestinal stroma tumor (HP:0100723)1.96763520
119Triphalangeal thumb (HP:0001199)1.95738077
120Congenital ichthyosiform erythroderma (HP:0007431)1.94370171
121Hyperglycinuria (HP:0003108)1.92227433
122Colon cancer (HP:0003003)1.92098965
123Optic disc pallor (HP:0000543)1.91633730
124Absent epiphyses (HP:0010577)1.91410838
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91410838
126Male pseudohermaphroditism (HP:0000037)1.90297870
127Partial agenesis of the corpus callosum (HP:0001338)1.90108527
128Petechiae (HP:0000967)1.89943305
129Nephrogenic diabetes insipidus (HP:0009806)1.89354654
130CNS demyelination (HP:0007305)1.88304041
131Rhabdomyolysis (HP:0003201)1.88198715
132Personality changes (HP:0000751)1.85660213
133Postnatal microcephaly (HP:0005484)1.84890745
134Abnormality of alanine metabolism (HP:0010916)1.84525255
135Hyperalaninemia (HP:0003348)1.84525255
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84525255
137Genital tract atresia (HP:0001827)1.83351042
138Dandy-Walker malformation (HP:0001305)1.82488845
139Hyperventilation (HP:0002883)1.82234665
140Sloping forehead (HP:0000340)1.81884343
141Large for gestational age (HP:0001520)1.81789156
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.80311070
143Lissencephaly (HP:0001339)1.79858576
144Postaxial foot polydactyly (HP:0001830)1.79634705
145Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79097189
146Degeneration of the lateral corticospinal tracts (HP:0002314)1.79097189
147X-linked dominant inheritance (HP:0001423)1.78985386
148Keratoconus (HP:0000563)1.78480617
149Increased corneal curvature (HP:0100692)1.78480617
150Supernumerary spleens (HP:0009799)1.78425254
151Vaginal atresia (HP:0000148)1.78342483
152Exercise-induced muscle cramps (HP:0003710)1.77625962
153Abnormal spermatogenesis (HP:0008669)1.76772674
154Congenital hepatic fibrosis (HP:0002612)1.76239213
155Small intestinal stenosis (HP:0012848)1.76024783
156Duodenal stenosis (HP:0100867)1.76024783
157Cerebral inclusion bodies (HP:0100314)1.75332362
158Astigmatism (HP:0000483)1.74034778
159Preaxial hand polydactyly (HP:0001177)1.73289985
160Oligodactyly (hands) (HP:0001180)1.72856877
161Autoamputation (HP:0001218)1.72425793
162Thrombocytosis (HP:0001894)1.72188612
163Macrocytic anemia (HP:0001972)1.72002483
164Hyperglycinemia (HP:0002154)1.71704070
165Abnormality of the pons (HP:0007361)1.71684646
166Reticulocytopenia (HP:0001896)1.71484353
167Methylmalonic acidemia (HP:0002912)1.71361136
168Increased neuronal autofluorescent lipopigment (HP:0002074)1.71275789
169Severe muscular hypotonia (HP:0006829)1.70989595
170Exercise-induced myalgia (HP:0003738)1.70919475
171Lethargy (HP:0001254)1.70797184
172Anophthalmia (HP:0000528)1.70259848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.87058088
2FRK3.69351098
3NME23.24258648
4WEE13.06341619
5PBK2.90905917
6TLK12.70024819
7ACVR1B2.64200440
8WNK32.62419293
9STK162.61176210
10NUAK12.34063837
11TESK22.32501199
12PDK32.25188479
13PDK42.25188479
14MAPKAPK52.14995103
15STK392.14078833
16MKNK12.11664933
17GRK12.03284612
18MUSK2.01543415
19VRK12.00980859
20EIF2AK11.89197248
21CDC71.86873841
22STK241.85880665
23MAP4K11.80259262
24MKNK21.77444773
25MAP3K121.76505921
26TRIM281.68312844
27TNIK1.61073622
28EIF2AK31.59305630
29MST41.59145588
30INSRR1.58233416
31IRAK41.56792274
32MAP4K21.54379656
33BMPR1B1.54101943
34ADRBK21.48350563
35VRK21.47591587
36CCNB11.46163848
37TTK1.43211493
38CASK1.38589175
39MAP3K41.36280525
40RPS6KB21.33949057
41MAPK131.32290478
42TESK11.31790490
43PLK41.29636877
44CDK81.29522300
45NEK61.23318458
46MAP2K71.21832888
47TGFBR11.21404499
48PLK31.21282394
49PLK11.17783296
50CSNK1G31.16354284
51NEK21.15028427
52PINK11.09759203
53TAOK31.03493083
54TSSK61.01950727
55PDK21.00502184
56LIMK10.99467377
57MYLK0.98150400
58BMPR20.95946309
59MAPKAPK30.95714665
60CDK190.95244722
61AURKA0.95006057
62AURKB0.92718650
63OXSR10.90727710
64CHEK20.86606632
65PTK2B0.85234415
66CSNK1G10.85125683
67KDR0.85086122
68RIPK40.83446025
69PAK30.82787776
70SRPK10.81586167
71BRSK20.79613148
72DYRK20.78152985
73MELK0.77178217
74ATR0.76987341
75PRKCQ0.73697639
76CLK10.70242080
77NEK10.69216942
78BRAF0.68927393
79ADRBK10.68807560
80PRKCG0.68405924
81SYK0.67481172
82KIT0.66663484
83CAMKK20.65859731
84PNCK0.65296403
85STK38L0.65159877
86TIE10.64958789
87FGFR20.64387673
88RPS6KA50.63587942
89OBSCN0.63005666
90BCKDK0.61344281
91DYRK30.60987801
92DAPK20.60040885
93PAK10.59486219
94CAMK2B0.59131194
95MAP3K110.58710546
96CAMKK10.58466013
97GRK60.58460742
98PRKCI0.57458705
99NME10.57125837
100EIF2AK20.56989847
101TAF10.56909649
102CHUK0.55787433
103WNK40.55338456
104PASK0.54991059
105ERBB30.54504573
106PRKCE0.53059120
107CDK40.52293367
108PLK20.52164104
109BCR0.50804978
110CHEK10.50691394
111TEC0.50596765
112CDK70.49376256
113CSNK2A20.49205006
114STK100.48388701
115IRAK10.46276377
116ATM0.45452979
117IKBKB0.45450659
118CSNK2A10.44794319
119CSNK1A1L0.42142422
120CSNK1G20.41268120
121LYN0.40885188
122TNK20.39994656
123ILK0.39332157
124PHKG20.38460661
125PHKG10.38460661
126RPS6KB10.38011458
127TXK0.37719405
128ZAK0.37193451
129MAP3K80.36962038
130MAPK40.35502636
131IRAK30.34905085
132MAP2K60.34690052
133CSF1R0.33330305
134MAP2K10.32243054
135BRSK10.32112374
136PIK3CA0.31767524
137CAMK2D0.31096164
138LCK0.30569124
139CAMK2A0.30528864
140STK30.29414990
141CSNK1D0.29341888
142RPS6KA40.29233753
143MAPK150.28464169
144UHMK10.28121422

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.52479624
2DNA replication_Homo sapiens_hsa030303.46892984
3Oxidative phosphorylation_Homo sapiens_hsa001903.43407111
4Mismatch repair_Homo sapiens_hsa034303.13783200
5Parkinsons disease_Homo sapiens_hsa050123.08491492
6RNA polymerase_Homo sapiens_hsa030202.73959557
7Ribosome_Homo sapiens_hsa030102.70005128
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.60349629
9Fatty acid elongation_Homo sapiens_hsa000622.58949379
10Protein export_Homo sapiens_hsa030602.53459749
11Huntingtons disease_Homo sapiens_hsa050162.44417461
12Sulfur relay system_Homo sapiens_hsa041222.38826088
13Nucleotide excision repair_Homo sapiens_hsa034202.32332294
14Alzheimers disease_Homo sapiens_hsa050102.29344468
15Vitamin B6 metabolism_Homo sapiens_hsa007502.14065103
16Basal transcription factors_Homo sapiens_hsa030222.03193793
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00808679
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99741906
19Spliceosome_Homo sapiens_hsa030401.97774781
20Phototransduction_Homo sapiens_hsa047441.96685685
21Nitrogen metabolism_Homo sapiens_hsa009101.92057091
22Pyrimidine metabolism_Homo sapiens_hsa002401.83946849
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.83040063
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82413863
25Homologous recombination_Homo sapiens_hsa034401.80456438
26RNA transport_Homo sapiens_hsa030131.79306511
27Butanoate metabolism_Homo sapiens_hsa006501.78953059
28Non-homologous end-joining_Homo sapiens_hsa034501.78813343
29Base excision repair_Homo sapiens_hsa034101.66217279
30RNA degradation_Homo sapiens_hsa030181.65570322
31Glutathione metabolism_Homo sapiens_hsa004801.64209001
32Propanoate metabolism_Homo sapiens_hsa006401.59560886
33Cell cycle_Homo sapiens_hsa041101.58328943
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.49674287
35Folate biosynthesis_Homo sapiens_hsa007901.35431113
36Pentose phosphate pathway_Homo sapiens_hsa000301.32305024
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30244730
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28422927
39Tryptophan metabolism_Homo sapiens_hsa003801.27416049
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.23537023
41Purine metabolism_Homo sapiens_hsa002301.22444845
42Pyruvate metabolism_Homo sapiens_hsa006201.16199464
43Nicotine addiction_Homo sapiens_hsa050331.12254336
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10917624
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09779223
46Fanconi anemia pathway_Homo sapiens_hsa034601.03577382
47Cardiac muscle contraction_Homo sapiens_hsa042601.02120594
48Olfactory transduction_Homo sapiens_hsa047400.98875364
49Histidine metabolism_Homo sapiens_hsa003400.98032532
50Carbon metabolism_Homo sapiens_hsa012000.93994393
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91859136
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88366959
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87536966
54Ether lipid metabolism_Homo sapiens_hsa005650.86863964
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85587741
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.84086191
57Sulfur metabolism_Homo sapiens_hsa009200.81743024
58Selenocompound metabolism_Homo sapiens_hsa004500.81162037
59Metabolic pathways_Homo sapiens_hsa011000.81049611
60Primary immunodeficiency_Homo sapiens_hsa053400.80805388
61Oocyte meiosis_Homo sapiens_hsa041140.80393993
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79464053
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76267030
64Steroid biosynthesis_Homo sapiens_hsa001000.73373955
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71631108
66Linoleic acid metabolism_Homo sapiens_hsa005910.69388154
67One carbon pool by folate_Homo sapiens_hsa006700.66925898
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66489716
69Sphingolipid metabolism_Homo sapiens_hsa006000.66305095
70Arachidonic acid metabolism_Homo sapiens_hsa005900.65100087
71Arginine and proline metabolism_Homo sapiens_hsa003300.64684037
72Epstein-Barr virus infection_Homo sapiens_hsa051690.64361448
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62416508
74Morphine addiction_Homo sapiens_hsa050320.61364952
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59255867
76Biosynthesis of amino acids_Homo sapiens_hsa012300.58642202
77Vitamin digestion and absorption_Homo sapiens_hsa049770.57848777
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57060352
79Systemic lupus erythematosus_Homo sapiens_hsa053220.54583987
80Taste transduction_Homo sapiens_hsa047420.54274283
81mRNA surveillance pathway_Homo sapiens_hsa030150.53733507
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53320275
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.53223479
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52584382
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.52474392
86Retinol metabolism_Homo sapiens_hsa008300.52119383
87p53 signaling pathway_Homo sapiens_hsa041150.52082662
88Hedgehog signaling pathway_Homo sapiens_hsa043400.51732947
89Basal cell carcinoma_Homo sapiens_hsa052170.51531796
90beta-Alanine metabolism_Homo sapiens_hsa004100.49919164
91Fat digestion and absorption_Homo sapiens_hsa049750.49830212
92ABC transporters_Homo sapiens_hsa020100.47980125
93TGF-beta signaling pathway_Homo sapiens_hsa043500.47715140
94Insulin secretion_Homo sapiens_hsa049110.47319328
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46721411
96Chemical carcinogenesis_Homo sapiens_hsa052040.45968051
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45257031
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42314176
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38660180
100Peroxisome_Homo sapiens_hsa041460.37458444
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37103179
102Fatty acid metabolism_Homo sapiens_hsa012120.37040173
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.36707574
104Fatty acid degradation_Homo sapiens_hsa000710.35292646
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33603573
106Viral carcinogenesis_Homo sapiens_hsa052030.32156316
107Fructose and mannose metabolism_Homo sapiens_hsa000510.31408325
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30441099
109Antigen processing and presentation_Homo sapiens_hsa046120.30314134
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30275279
111Ovarian steroidogenesis_Homo sapiens_hsa049130.30086159
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29764515
113Galactose metabolism_Homo sapiens_hsa000520.29455965
114Serotonergic synapse_Homo sapiens_hsa047260.26159999
115Alcoholism_Homo sapiens_hsa050340.25844983
116Caffeine metabolism_Homo sapiens_hsa002320.23225293
117Collecting duct acid secretion_Homo sapiens_hsa049660.23178965
118Phagosome_Homo sapiens_hsa041450.23135746
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22551458
120Renin-angiotensin system_Homo sapiens_hsa046140.20820809
121Glycerolipid metabolism_Homo sapiens_hsa005610.18191577
122Herpes simplex infection_Homo sapiens_hsa051680.17871457
123Vibrio cholerae infection_Homo sapiens_hsa051100.17854551
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15989254
125B cell receptor signaling pathway_Homo sapiens_hsa046620.13835933
126Shigellosis_Homo sapiens_hsa051310.11741958
127Tyrosine metabolism_Homo sapiens_hsa003500.11552724
128Regulation of autophagy_Homo sapiens_hsa041400.11499283
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09834903
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08527206
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.08043916

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