TUBE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.39750570
2telomere maintenance via semi-conservative replication (GO:0032201)5.20432003
3DNA strand elongation (GO:0022616)5.14992398
4DNA unwinding involved in DNA replication (GO:0006268)5.07988415
5protein localization to kinetochore (GO:0034501)4.89112428
6DNA replication checkpoint (GO:0000076)4.85171051
7telomere maintenance via recombination (GO:0000722)4.79184146
8DNA replication initiation (GO:0006270)4.75706515
9mitotic recombination (GO:0006312)4.74463889
10mitotic chromosome condensation (GO:0007076)4.58576574
11kinetochore organization (GO:0051383)4.53893752
12CENP-A containing nucleosome assembly (GO:0034080)4.50713398
13chromatin remodeling at centromere (GO:0031055)4.48105413
14mitotic metaphase plate congression (GO:0007080)4.25662007
15telomere maintenance via telomere lengthening (GO:0010833)4.24458138
16nucleotide-excision repair, DNA gap filling (GO:0006297)4.23806693
17DNA replication-independent nucleosome organization (GO:0034724)4.18544704
18DNA replication-independent nucleosome assembly (GO:0006336)4.18544704
19protein localization to chromosome, centromeric region (GO:0071459)4.15664501
20mitotic sister chromatid segregation (GO:0000070)4.14348474
21attachment of spindle microtubules to kinetochore (GO:0008608)4.08263734
22metaphase plate congression (GO:0051310)4.01257040
23sister chromatid segregation (GO:0000819)3.96546056
24mitotic nuclear envelope disassembly (GO:0007077)3.92694449
25DNA replication-dependent nucleosome assembly (GO:0006335)3.92533551
26DNA replication-dependent nucleosome organization (GO:0034723)3.92533551
27protein-cofactor linkage (GO:0018065)3.88302752
28kinetochore assembly (GO:0051382)3.86120730
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.85140444
30ribosomal small subunit assembly (GO:0000028)3.83873557
31meiotic chromosome segregation (GO:0045132)3.81984776
32histone exchange (GO:0043486)3.74695862
33regulation of double-strand break repair via homologous recombination (GO:0010569)3.71794249
34mitotic sister chromatid cohesion (GO:0007064)3.70292419
35establishment of chromosome localization (GO:0051303)3.70107261
36synapsis (GO:0007129)3.67066452
37nucleobase biosynthetic process (GO:0046112)3.64260174
38translesion synthesis (GO:0019985)3.63478282
39membrane disassembly (GO:0030397)3.61893547
40nuclear envelope disassembly (GO:0051081)3.61893547
41nuclear pore organization (GO:0006999)3.61419810
42purine nucleobase biosynthetic process (GO:0009113)3.60456449
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.55426049
44somatic hypermutation of immunoglobulin genes (GO:0016446)3.55426049
45mismatch repair (GO:0006298)3.55239644
46telomere maintenance (GO:0000723)3.52294785
47telomere organization (GO:0032200)3.52147080
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48041435
49spindle checkpoint (GO:0031577)3.47934444
50IMP biosynthetic process (GO:0006188)3.47880341
51DNA synthesis involved in DNA repair (GO:0000731)3.45236447
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42365416
53postreplication repair (GO:0006301)3.41777179
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41698942
55chromosome segregation (GO:0007059)3.41397201
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41246588
57DNA geometric change (GO:0032392)3.40723808
58DNA duplex unwinding (GO:0032508)3.40091708
59nuclear pore complex assembly (GO:0051292)3.39200336
60protein localization to chromosome (GO:0034502)3.38609630
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37090733
62spindle assembly checkpoint (GO:0071173)3.33541269
63negative regulation of chromosome segregation (GO:0051985)3.32660343
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.31911942
65negative regulation of sister chromatid segregation (GO:0033046)3.31911942
66negative regulation of mitotic sister chromatid separation (GO:2000816)3.31911942
67negative regulation of mitotic sister chromatid segregation (GO:0033048)3.31911942
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.28297908
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.28245224
70regulation of spindle organization (GO:0090224)3.27247810
71DNA strand renaturation (GO:0000733)3.26622348
72regulation of chromosome segregation (GO:0051983)3.25542704
73chromatin assembly or disassembly (GO:0006333)3.23303153
74mitotic spindle assembly checkpoint (GO:0007094)3.22487074
75regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22388384
76DNA topological change (GO:0006265)3.20077804
77regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19812166
78water-soluble vitamin biosynthetic process (GO:0042364)3.17975069
79gamma-aminobutyric acid transport (GO:0015812)3.17319438
80mitotic spindle checkpoint (GO:0071174)3.17053148
81DNA conformation change (GO:0071103)3.15512974
82maturation of SSU-rRNA (GO:0030490)3.13266265
83histone H2A acetylation (GO:0043968)3.12897368
84regulation of centrosome cycle (GO:0046605)3.12069192
85folic acid-containing compound biosynthetic process (GO:0009396)3.10654713
86regulation of mitotic sister chromatid separation (GO:0010965)3.09787754
87regulation of mitotic sister chromatid segregation (GO:0033047)3.09787754
88regulation of sister chromatid segregation (GO:0033045)3.09787754
89regulation of sister chromatid cohesion (GO:0007063)3.08710244
90intra-S DNA damage checkpoint (GO:0031573)3.08653246
91ATP-dependent chromatin remodeling (GO:0043044)3.08341509
92behavioral response to nicotine (GO:0035095)3.08267051
93response to pheromone (GO:0019236)3.06643624
94replication fork processing (GO:0031297)3.04971878
95resolution of meiotic recombination intermediates (GO:0000712)3.03992378
96DNA packaging (GO:0006323)3.03653895
97base-excision repair (GO:0006284)3.03585155
98mitotic cell cycle (GO:0000278)3.02664225
99transcription-coupled nucleotide-excision repair (GO:0006283)3.02557088
100protein polyglutamylation (GO:0018095)3.01459404
101regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.00729100
102DNA double-strand break processing (GO:0000729)3.00571201
103regulation of histone H3-K9 methylation (GO:0051570)3.00264163
104chromosome condensation (GO:0030261)3.00258301
105nonmotile primary cilium assembly (GO:0035058)2.99544593
106indolalkylamine metabolic process (GO:0006586)2.98342342
107regulation of centriole replication (GO:0046599)2.97832446
108establishment of integrated proviral latency (GO:0075713)2.97697180
109DNA deamination (GO:0045006)2.96952975
110regulation of glucokinase activity (GO:0033131)2.96366487
111regulation of hexokinase activity (GO:1903299)2.96366487
112DNA replication (GO:0006260)2.95830694
113negative regulation of DNA-dependent DNA replication (GO:2000104)2.95483858
114centriole replication (GO:0007099)2.94778620
115protein localization to cilium (GO:0061512)2.90047414
116tryptophan catabolic process (GO:0006569)2.89265176
117indole-containing compound catabolic process (GO:0042436)2.89265176
118indolalkylamine catabolic process (GO:0046218)2.89265176
119behavioral response to ethanol (GO:0048149)2.88971624
120epithelial cilium movement (GO:0003351)2.83829809
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77022700
122cilium organization (GO:0044782)2.75311480
123regulation of acyl-CoA biosynthetic process (GO:0050812)2.74683397
124piRNA metabolic process (GO:0034587)2.74490197
125regulation of meiosis I (GO:0060631)2.74332621
126L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71603996
127cilium assembly (GO:0042384)2.71582825
128peptidyl-histidine modification (GO:0018202)2.70072960
129reflex (GO:0060004)2.69861973
130pyrimidine nucleobase catabolic process (GO:0006208)2.69387574
131male meiosis I (GO:0007141)2.68542901
132startle response (GO:0001964)2.67289811
133detection of light stimulus involved in visual perception (GO:0050908)2.66713172
134detection of light stimulus involved in sensory perception (GO:0050962)2.66713172
135recombinational repair (GO:0000725)2.66202627
136axoneme assembly (GO:0035082)2.65683033
137kynurenine metabolic process (GO:0070189)2.64480085
138intraciliary transport (GO:0042073)2.63533150
139cellular ketone body metabolic process (GO:0046950)2.63483035
140double-strand break repair via homologous recombination (GO:0000724)2.62393706
141presynaptic membrane assembly (GO:0097105)2.61325407
142dopamine transport (GO:0015872)2.59579910
143regulation of DNA endoreduplication (GO:0032875)2.58889912
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57908714
145mitochondrial respiratory chain complex I assembly (GO:0032981)2.57908714
146NADH dehydrogenase complex assembly (GO:0010257)2.57908714
147mitochondrial respiratory chain complex assembly (GO:0033108)2.57490792
148amino acid salvage (GO:0043102)2.57369514
149L-methionine salvage (GO:0071267)2.57369514
150L-methionine biosynthetic process (GO:0071265)2.57369514
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55475038
152protein complex biogenesis (GO:0070271)2.54446650
153retinal cone cell development (GO:0046549)2.53202202
154protein prenylation (GO:0018342)2.53105108
155prenylation (GO:0097354)2.53105108
156tryptophan metabolic process (GO:0006568)2.53055103
157S-adenosylmethionine metabolic process (GO:0046500)2.51327709
158protein K11-linked deubiquitination (GO:0035871)2.51302011
159reciprocal meiotic recombination (GO:0007131)2.50317964
160reciprocal DNA recombination (GO:0035825)2.50317964
161protein K6-linked ubiquitination (GO:0085020)2.50186603
162photoreceptor cell maintenance (GO:0045494)2.48882686
163ribonucleoprotein complex disassembly (GO:0032988)2.48565290
164respiratory chain complex IV assembly (GO:0008535)2.47947398
165photoreceptor cell development (GO:0042461)2.46758543
166cilium morphogenesis (GO:0060271)2.43821297
167RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.43059784
168righting reflex (GO:0060013)2.41731430
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39736669
170ketone body metabolic process (GO:1902224)2.38365304
171eye photoreceptor cell development (GO:0042462)2.37653581
172microtubule anchoring (GO:0034453)2.36370624
173presynaptic membrane organization (GO:0097090)2.35659242
174C4-dicarboxylate transport (GO:0015740)2.35385958
175regulation of cilium movement (GO:0003352)2.34372091
176negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34369562
177acrosome reaction (GO:0007340)2.34248012
178transmission of nerve impulse (GO:0019226)2.33038589
179negative regulation of DNA recombination (GO:0045910)2.30922592
180neural tube formation (GO:0001841)2.30790906
181nucleobase catabolic process (GO:0046113)2.30331350
182cilium movement (GO:0003341)2.29154325
183mannosylation (GO:0097502)2.28740957
184L-fucose catabolic process (GO:0042355)2.27884362
185fucose catabolic process (GO:0019317)2.27884362
186L-fucose metabolic process (GO:0042354)2.27884362
187positive regulation of glycolytic process (GO:0045821)2.27402797
188rRNA catabolic process (GO:0016075)2.26871462
189branched-chain amino acid catabolic process (GO:0009083)2.26562268
190establishment of protein localization to mitochondrial membrane (GO:0090151)2.26397431
191regulation of cofactor metabolic process (GO:0051193)2.26073502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.25425623
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.64836739
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.80545591
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.75077190
5ZNF274_21170338_ChIP-Seq_K562_Hela3.12675223
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11640960
7VDR_22108803_ChIP-Seq_LS180_Human3.07102092
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99041391
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87622552
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.85195019
11GBX2_23144817_ChIP-Seq_PC3_Human2.85175761
12FUS_26573619_Chip-Seq_HEK293_Human2.70878908
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66664590
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61541217
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60048875
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56308562
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55429314
18IGF1R_20145208_ChIP-Seq_DFB_Human2.49274064
19TAF15_26573619_Chip-Seq_HEK293_Human2.45848529
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45461355
21AR_21909140_ChIP-Seq_LNCAP_Human2.40726949
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37996701
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.36932324
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33523527
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32186782
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.31905875
27EWS_26573619_Chip-Seq_HEK293_Human2.31640850
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.31333643
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23834573
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23667263
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20246186
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17047544
33XRN2_22483619_ChIP-Seq_HELA_Human2.16618496
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16315369
35FLI1_27457419_Chip-Seq_LIVER_Mouse2.13128568
36P300_19829295_ChIP-Seq_ESCs_Human2.12639962
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11867029
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08800276
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08714393
40VDR_23849224_ChIP-Seq_CD4+_Human2.04996265
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00026485
42E2F7_22180533_ChIP-Seq_HELA_Human11.4127632
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98829518
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97567140
45FOXP3_21729870_ChIP-Seq_TREG_Human1.95546642
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.93150751
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91736224
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91515529
49DCP1A_22483619_ChIP-Seq_HELA_Human1.90902099
50CIITA_25753668_ChIP-Seq_RAJI_Human1.86430417
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85287639
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83386628
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81901337
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78860599
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76540759
56GABP_19822575_ChIP-Seq_HepG2_Human1.75874272
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74204361
58* TTF2_22483619_ChIP-Seq_HELA_Human1.73746480
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.72070687
60EZH2_22144423_ChIP-Seq_EOC_Human1.69874229
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69398744
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68751335
63SMAD4_21799915_ChIP-Seq_A2780_Human1.68501503
64* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67794741
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64617967
66ER_23166858_ChIP-Seq_MCF-7_Human1.63756173
67* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63209538
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62774991
69ELK1_19687146_ChIP-ChIP_HELA_Human1.62632448
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62360870
71CBP_20019798_ChIP-Seq_JUKART_Human1.62360870
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61864260
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61639035
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60625922
75* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59216569
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58922946
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.57872129
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57673168
79MYC_22102868_ChIP-Seq_BL_Human1.57188303
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56257139
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54450617
82STAT3_23295773_ChIP-Seq_U87_Human1.50509408
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50128497
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48191793
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43795711
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43595113
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.43397873
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42107970
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41810660
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41287902
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.40877675
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40753763
93RNF2_27304074_Chip-Seq_NSC_Mouse1.39591671
94BCAT_22108803_ChIP-Seq_LS180_Human1.39202864
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38896163
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36956952
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.36242204
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.36078143
99TCF4_23295773_ChIP-Seq_U87_Human1.35748672
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35279275
101KDM5A_27292631_Chip-Seq_BREAST_Human1.33946005
102AR_25329375_ChIP-Seq_VCAP_Human1.33343740
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.33225023
104TP53_22573176_ChIP-Seq_HFKS_Human1.30663243
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30500086
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29535923
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28442557
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28304723
109RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27357688
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.26921596
111TCF4_22108803_ChIP-Seq_LS180_Human1.25886936
112SOX2_19829295_ChIP-Seq_ESCs_Human1.25862589
113NANOG_19829295_ChIP-Seq_ESCs_Human1.25862589
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25816661
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25462094
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25340814
117PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25321731
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.24109702
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23277293
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22847719
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22344043
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21872203
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.20783009
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20194937
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20006095
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18708688
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.18266661
128P53_22387025_ChIP-Seq_ESCs_Mouse1.17529938
129SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17240264
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16718424
131RUNX2_22187159_ChIP-Seq_PCA_Human1.16463360
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16295130
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14912434
134* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14331118
135MYC_18940864_ChIP-ChIP_HL60_Human1.11560539
136POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11306061
137E2F1_18555785_Chip-Seq_ESCs_Mouse1.10832140
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07437377
139AR_21572438_ChIP-Seq_LNCaP_Human1.06845003
140STAT3_18555785_Chip-Seq_ESCs_Mouse1.06298838
141FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05615543
142SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05493347
143* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05017024
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04893136
145SMAD4_21741376_ChIP-Seq_EPCs_Human1.04743915
146P300_18555785_Chip-Seq_ESCs_Mouse1.03946042
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03762718
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03762718
149* CDX2_22108803_ChIP-Seq_LS180_Human1.02951496
150OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02436573
151TAL1_26923725_Chip-Seq_HPCs_Mouse1.02315698
152NOTCH1_21737748_ChIP-Seq_TLL_Human1.01688801
153* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99190711
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98456923
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97653065
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96821166
157* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95679410
158SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95587444
159SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95075482
160ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94686331
161POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91897113
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91148697
163KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90320668
164NANOG_21062744_ChIP-ChIP_HESCs_Human0.87814241
165PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84432116
166DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84402800
167TFEB_21752829_ChIP-Seq_HELA_Human0.84154269
168VDR_21846776_ChIP-Seq_THP-1_Human0.83457108
169* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82778541
170CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78144759
171* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77180869
172IRF1_19129219_ChIP-ChIP_H3396_Human0.77070475
173BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76627453
174CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75342795
175SPI1_23547873_ChIP-Seq_NB4_Human0.74757638
176SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72935523
177STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66613655
178SOX2_16153702_ChIP-ChIP_HESCs_Human0.63445387
179KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.62444891
180MYB_26560356_Chip-Seq_TH2_Human0.61935736
181TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.60219637
182FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58939332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.33440642
2MP0003693_abnormal_embryo_hatching4.75185269
3MP0003111_abnormal_nucleus_morphology4.59037470
4MP0008057_abnormal_DNA_replication4.53015256
5MP0003077_abnormal_cell_cycle4.06463255
6MP0004957_abnormal_blastocyst_morpholog3.86258588
7MP0008058_abnormal_DNA_repair3.47005690
8MP0003123_paternal_imprinting2.99114553
9MP0008932_abnormal_embryonic_tissue2.72284574
10MP0008877_abnormal_DNA_methylation2.65872969
11MP0008007_abnormal_cellular_replicative2.54795272
12MP0003121_genomic_imprinting2.44880244
13MP0002396_abnormal_hematopoietic_system2.20496320
14MP0003195_calcinosis2.19265772
15MP0003880_abnormal_central_pattern2.18348270
16MP0009046_muscle_twitch2.13692977
17MP0005551_abnormal_eye_electrophysiolog2.10344666
18MP0000350_abnormal_cell_proliferation2.07199567
19MP0001730_embryonic_growth_arrest1.98574460
20MP0002638_abnormal_pupillary_reflex1.90163207
21MP0009745_abnormal_behavioral_response1.83082138
22MP0002234_abnormal_pharynx_morphology1.80870389
23MP0003763_abnormal_thymus_physiology1.78016383
24MP0001984_abnormal_olfaction1.76959686
25MP0001986_abnormal_taste_sensitivity1.76850680
26MP0000490_abnormal_crypts_of1.68276862
27MP0001968_abnormal_touch/_nociception1.68172013
28MP0002837_dystrophic_cardiac_calcinosis1.67691246
29MP0010307_abnormal_tumor_latency1.67441403
30MP0002272_abnormal_nervous_system1.66802550
31MP0001672_abnormal_embryogenesis/_devel1.60956672
32MP0005380_embryogenesis_phenotype1.60956672
33MP0002736_abnormal_nociception_after1.60818259
34MP0000631_abnormal_neuroendocrine_gland1.59922155
35MP0001486_abnormal_startle_reflex1.59764235
36MP0004215_abnormal_myocardial_fiber1.59657873
37MP0003786_premature_aging1.59493479
38MP0008875_abnormal_xenobiotic_pharmacok1.59272666
39MP0000703_abnormal_thymus_morphology1.59056953
40MP0001697_abnormal_embryo_size1.56576840
41MP0004142_abnormal_muscle_tone1.56103902
42MP0004808_abnormal_hematopoietic_stem1.55896028
43MP0003787_abnormal_imprinting1.54043537
44MP0006292_abnormal_olfactory_placode1.54043461
45MP0005646_abnormal_pituitary_gland1.53228162
46MP0008872_abnormal_physiological_respon1.52347801
47MP0006276_abnormal_autonomic_nervous1.51744020
48MP0010352_gastrointestinal_tract_polyps1.45138832
49MP0002085_abnormal_embryonic_tissue1.44287773
50MP0003984_embryonic_growth_retardation1.43860054
51MP0000313_abnormal_cell_death1.41151652
52MP0002088_abnormal_embryonic_growth/wei1.40934692
53MP0005187_abnormal_penis_morphology1.39196528
54MP0004885_abnormal_endolymph1.38682520
55MP0008995_early_reproductive_senescence1.38481959
56MP0003718_maternal_effect1.35906855
57MP0002019_abnormal_tumor_incidence1.35079098
58MP0004147_increased_porphyrin_level1.35026315
59MP0002210_abnormal_sex_determination1.34960040
60MP0002132_abnormal_respiratory_system1.34407492
61MP0002080_prenatal_lethality1.34008741
62MP0000778_abnormal_nervous_system1.32842094
63MP0002064_seizures1.31247210
64MP0003635_abnormal_synaptic_transmissio1.27398401
65MP0003315_abnormal_perineum_morphology1.26955003
66MP0004197_abnormal_fetal_growth/weight/1.26410929
67MP0005645_abnormal_hypothalamus_physiol1.25723585
68MP0002572_abnormal_emotion/affect_behav1.22208777
69MP0010030_abnormal_orbit_morphology1.21138145
70MP0000015_abnormal_ear_pigmentation1.20747330
71MP0002084_abnormal_developmental_patter1.20534920
72MP0001293_anophthalmia1.20324821
73MP0003567_abnormal_fetal_cardiomyocyte1.19249363
74MP0001119_abnormal_female_reproductive1.18535213
75MP0002095_abnormal_skin_pigmentation1.18037051
76MP0003136_yellow_coat_color1.17886007
77MP0004859_abnormal_synaptic_plasticity1.16625270
78MP0000372_irregular_coat_pigmentation1.16009674
79MP0001485_abnormal_pinna_reflex1.15534706
80MP0004924_abnormal_behavior1.15517912
81MP0005386_behavior/neurological_phenoty1.15517912
82MP0002086_abnormal_extraembryonic_tissu1.15269587
83MP0002735_abnormal_chemical_nociception1.13586452
84MP0005076_abnormal_cell_differentiation1.13518913
85MP0002557_abnormal_social/conspecific_i1.12641347
86MP0002398_abnormal_bone_marrow1.12586799
87MP0002067_abnormal_sensory_capabilities1.12577819
88MP0001145_abnormal_male_reproductive1.10391224
89MP0005174_abnormal_tail_pigmentation1.09712984
90MP0002722_abnormal_immune_system1.09197277
91MP0001929_abnormal_gametogenesis1.08714833
92MP0003137_abnormal_impulse_conducting1.07917866
93MP0002063_abnormal_learning/memory/cond1.07400354
94MP0003698_abnormal_male_reproductive1.05725538
95MP0003122_maternal_imprinting1.05222525
96MP0000653_abnormal_sex_gland1.02753372
97MP0004043_abnormal_pH_regulation1.01758728
98MP0001764_abnormal_homeostasis0.99922639
99MP0000427_abnormal_hair_cycle0.99400935
100MP0001915_intracranial_hemorrhage0.99038754
101MP0000689_abnormal_spleen_morphology0.97373538
102MP0002653_abnormal_ependyma_morphology0.97153057
103MP0002734_abnormal_mechanical_nocicepti0.96769194
104MP0003283_abnormal_digestive_organ0.96538753
105MP0005410_abnormal_fertilization0.96473506
106MP0002102_abnormal_ear_morphology0.96421255
107MP0003119_abnormal_digestive_system0.95976527
108MP0000566_synostosis0.95888697
109MP0001545_abnormal_hematopoietic_system0.95017210
110MP0005397_hematopoietic_system_phenotyp0.95017210
111MP0001501_abnormal_sleep_pattern0.94581439
112MP0006054_spinal_hemorrhage0.94459050
113MP0005394_taste/olfaction_phenotype0.92663765
114MP0005499_abnormal_olfactory_system0.92663765
115MP0001440_abnormal_grooming_behavior0.92474595
116MP0002090_abnormal_vision0.92132934
117MP0002160_abnormal_reproductive_system0.91938160
118MP0002822_catalepsy0.91890053
119MP0004134_abnormal_chest_morphology0.91478797
120MP0006035_abnormal_mitochondrial_morpho0.91443688
121MP0004742_abnormal_vestibular_system0.90387936
122MP0000537_abnormal_urethra_morphology0.90170023
123MP0002938_white_spotting0.88910481
124MP0000516_abnormal_urinary_system0.88514025
125MP0005367_renal/urinary_system_phenotyp0.88514025
126MP0002928_abnormal_bile_duct0.87537077
127MP0003890_abnormal_embryonic-extraembry0.86946759
128MP0000569_abnormal_digit_pigmentation0.86781367
129MP0001286_abnormal_eye_development0.85416000
130MP0004085_abnormal_heartbeat0.85095200
131MP0002184_abnormal_innervation0.84748329
132MP0000647_abnormal_sebaceous_gland0.83969655
133MP0002752_abnormal_somatic_nervous0.83722255
134MP0005195_abnormal_posterior_eye0.82696251
135MP0009333_abnormal_splenocyte_physiolog0.82180204
136MP0000955_abnormal_spinal_cord0.81726287
137MP0000678_abnormal_parathyroid_gland0.80982386
138MP0002751_abnormal_autonomic_nervous0.80957535
139MP0005075_abnormal_melanosome_morpholog0.80630566
140MP0002233_abnormal_nose_morphology0.80403673
141MP0005085_abnormal_gallbladder_physiolo0.80107301
142MP0000026_abnormal_inner_ear0.79911115
143MP0009053_abnormal_anal_canal0.78547561
144MP0002429_abnormal_blood_cell0.77550330
145MP0009379_abnormal_foot_pigmentation0.76321261
146MP0002075_abnormal_coat/hair_pigmentati0.75681646
147MP0005391_vision/eye_phenotype0.75607313
148MP0003937_abnormal_limbs/digits/tail_de0.75322113
149MP0005389_reproductive_system_phenotype0.72866788
150MP0000716_abnormal_immune_system0.71173475
151MP0002092_abnormal_eye_morphology0.70147702
152MP0005384_cellular_phenotype0.69255579
153MP0009697_abnormal_copulation0.67600627
154MP0001529_abnormal_vocalization0.66554894
155MP0003950_abnormal_plasma_membrane0.66419618
156MP0001186_pigmentation_phenotype0.66127259
157MP0002111_abnormal_tail_morphology0.65913726
158MP0006072_abnormal_retinal_apoptosis0.65016539
159MP0005253_abnormal_eye_physiology0.64470315
160MP0008789_abnormal_olfactory_epithelium0.64101713
161MP0004133_heterotaxia0.60448671
162MP0003699_abnormal_female_reproductive0.60359555
163MP0005671_abnormal_response_to0.60331958
164MP0009703_decreased_birth_body0.60311931
165MP0000049_abnormal_middle_ear0.60243255
166MP0002163_abnormal_gland_morphology0.59892387
167MP0002249_abnormal_larynx_morphology0.59724193
168MP0003011_delayed_dark_adaptation0.58837150
169MP0000428_abnormal_craniofacial_morphol0.57901747

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.68248415
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33864211
3Birth length less than 3rd percentile (HP:0003561)4.22804530
4Abnormality of chromosome stability (HP:0003220)3.89780104
5Colon cancer (HP:0003003)3.83775177
6Pancreatic fibrosis (HP:0100732)3.83131556
7Reticulocytopenia (HP:0001896)3.71915602
8Pancreatic cysts (HP:0001737)3.69622441
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.48197806
10True hermaphroditism (HP:0010459)3.47979483
11Medulloblastoma (HP:0002885)3.38097865
12Abnormality of midbrain morphology (HP:0002418)3.34070787
13Molar tooth sign on MRI (HP:0002419)3.34070787
14Abnormal number of incisors (HP:0011064)3.31767532
15Meckel diverticulum (HP:0002245)3.25093875
16Medial flaring of the eyebrow (HP:0010747)3.23742053
17Hypothermia (HP:0002045)3.18691396
18Abnormality of the ileum (HP:0001549)3.17272599
19Selective tooth agenesis (HP:0001592)3.16096041
20Abnormality of the preputium (HP:0100587)3.15389313
21Volvulus (HP:0002580)3.11608324
22Patellar aplasia (HP:0006443)3.06117091
23Nephronophthisis (HP:0000090)3.01902756
24Impulsivity (HP:0100710)3.01088103
25Gait imbalance (HP:0002141)2.93399193
26Agnosia (HP:0010524)2.90007022
27Small intestinal stenosis (HP:0012848)2.89302794
28Duodenal stenosis (HP:0100867)2.89302794
29Ependymoma (HP:0002888)2.89217180
30Ectopic kidney (HP:0000086)2.87128222
31Oral leukoplakia (HP:0002745)2.86985477
32Hypoplasia of the thymus (HP:0000778)2.86816164
33Congenital primary aphakia (HP:0007707)2.86553524
34Severe visual impairment (HP:0001141)2.82736325
35Chronic hepatic failure (HP:0100626)2.82073451
36Myelodysplasia (HP:0002863)2.81254480
37Aplasia/Hypoplasia of the patella (HP:0006498)2.80252677
38Breast hypoplasia (HP:0003187)2.79628131
39Abnormal number of erythroid precursors (HP:0012131)2.75066326
40Absent thumb (HP:0009777)2.74083732
41Hyperventilation (HP:0002883)2.73851700
42Nephrogenic diabetes insipidus (HP:0009806)2.73430068
43Supernumerary spleens (HP:0009799)2.72967680
44Combined immunodeficiency (HP:0005387)2.71488645
45Rhabdomyosarcoma (HP:0002859)2.70090159
46Abnormality of the renal cortex (HP:0011035)2.69807192
47Cellular immunodeficiency (HP:0005374)2.69217857
48Intestinal atresia (HP:0011100)2.68813158
49Severe combined immunodeficiency (HP:0004430)2.67560563
50Genital tract atresia (HP:0001827)2.65553595
51Abnormality of cells of the erythroid lineage (HP:0012130)2.65373274
52Aplastic anemia (HP:0001915)2.63356459
53Renal cortical cysts (HP:0000803)2.56678308
54Sloping forehead (HP:0000340)2.56495797
55Abnormality of the renal medulla (HP:0100957)2.56293595
56Pendular nystagmus (HP:0012043)2.54828154
57Nephroblastoma (Wilms tumor) (HP:0002667)2.54430123
58Febrile seizures (HP:0002373)2.53574957
59B lymphocytopenia (HP:0010976)2.48147336
60Abnormality of B cell number (HP:0010975)2.48147336
61Bone marrow hypocellularity (HP:0005528)2.47961891
62Abnormality of the duodenum (HP:0002246)2.47748690
63Increased nuchal translucency (HP:0010880)2.46827389
64Type II lissencephaly (HP:0007260)2.46568298
65Methylmalonic acidemia (HP:0002912)2.45851504
66Absent radius (HP:0003974)2.43944603
67Abnormality of abdominal situs (HP:0011620)2.42403174
68Abdominal situs inversus (HP:0003363)2.42403174
69T lymphocytopenia (HP:0005403)2.42177255
7011 pairs of ribs (HP:0000878)2.41413748
71Triphalangeal thumb (HP:0001199)2.40458032
72Embryonal renal neoplasm (HP:0011794)2.39593912
73Vaginal atresia (HP:0000148)2.38711237
74IgM deficiency (HP:0002850)2.35889942
75Aplasia involving forearm bones (HP:0009822)2.34167321
76Absent forearm bone (HP:0003953)2.34167321
77Abnormal lung lobation (HP:0002101)2.33603705
78Abnormality of the carotid arteries (HP:0005344)2.32021698
79Abnormality of the anterior horn cell (HP:0006802)2.31786821
80Degeneration of anterior horn cells (HP:0002398)2.31786821
81Atonic seizures (HP:0010819)2.29539192
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.28146246
83Congenital stationary night blindness (HP:0007642)2.27404133
84Postaxial foot polydactyly (HP:0001830)2.26348106
85Oligodactyly (hands) (HP:0001180)2.24226702
86Abolished electroretinogram (ERG) (HP:0000550)2.22192092
87Optic nerve hypoplasia (HP:0000609)2.20317991
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.20249038
89Abnormality of T cell number (HP:0011839)2.20248159
90Duplicated collecting system (HP:0000081)2.19809681
91Hypoglycemic coma (HP:0001325)2.18592097
92Cystic liver disease (HP:0006706)2.18481657
93Premature graying of hair (HP:0002216)2.17988279
94Poor coordination (HP:0002370)2.16937170
95Abnormal biliary tract physiology (HP:0012439)2.16557197
96Bile duct proliferation (HP:0001408)2.16557197
97Cafe-au-lait spot (HP:0000957)2.16105422
98Lymphoma (HP:0002665)2.15445397
99Gastrointestinal atresia (HP:0002589)2.13324612
100Gaze-evoked nystagmus (HP:0000640)2.10276006
101Tracheoesophageal fistula (HP:0002575)2.08528120
102Progressive cerebellar ataxia (HP:0002073)2.08266323
103Rough bone trabeculation (HP:0100670)2.06901436
104Progressive inability to walk (HP:0002505)2.06815696
105Degeneration of the lateral corticospinal tracts (HP:0002314)2.06310125
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06310125
107Thyroiditis (HP:0100646)2.05946136
108Abnormality of the labia minora (HP:0012880)2.05353608
109Focal motor seizures (HP:0011153)2.04748739
110Optic nerve coloboma (HP:0000588)2.04480455
111Postaxial hand polydactyly (HP:0001162)2.04261764
112Acute necrotizing encephalopathy (HP:0006965)2.03938653
113Neoplasm of the pancreas (HP:0002894)2.03700284
114Limb dystonia (HP:0002451)2.03257988
115Clubbing of toes (HP:0100760)2.02652573
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02391144
117Short tibia (HP:0005736)2.02313553
118Progressive macrocephaly (HP:0004481)2.01500293
119Aplasia/Hypoplasia of the thymus (HP:0010515)2.00867086
120Abnormality of the renal collecting system (HP:0004742)2.00068245
121Hyperinsulinemic hypoglycemia (HP:0000825)1.99881220
122Short thumb (HP:0009778)1.99703934
123Glioma (HP:0009733)1.99430777
124Abnormality of the fingertips (HP:0001211)1.99236180
125Cerebellar dysplasia (HP:0007033)1.99229749
126Specific learning disability (HP:0001328)1.98399596
127Abnormal rod and cone electroretinograms (HP:0008323)1.98360936
128Drooling (HP:0002307)1.98248631
129High pitched voice (HP:0001620)1.98164850
130Astrocytoma (HP:0009592)1.98072033
131Abnormality of the astrocytes (HP:0100707)1.98072033
132Basal cell carcinoma (HP:0002671)1.97653088
133Neoplasm of the colon (HP:0100273)1.97479173
134Broad-based gait (HP:0002136)1.96928352
135Diastasis recti (HP:0001540)1.95264162
136Neoplasm of striated muscle (HP:0009728)1.94960097
137Hypoglycemic seizures (HP:0002173)1.94358110
138Abnormality of DNA repair (HP:0003254)1.94296778
139Neoplasm of the oral cavity (HP:0100649)1.93863904
140Median cleft lip (HP:0000161)1.93154194
141Pallor (HP:0000980)1.92805167
142Proximal placement of thumb (HP:0009623)1.92559172
143Carpal bone hypoplasia (HP:0001498)1.92512240
144Amaurosis fugax (HP:0100576)1.92219869
145IgG deficiency (HP:0004315)1.91436792
146Prominent nose (HP:0000448)1.89077620
147Microretrognathia (HP:0000308)1.88964228
148Acute encephalopathy (HP:0006846)1.88444976
149Horseshoe kidney (HP:0000085)1.87702356
150Attenuation of retinal blood vessels (HP:0007843)1.87411629
151Increased CSF lactate (HP:0002490)1.86260267
152Deviation of the thumb (HP:0009603)1.86078664
153Tubulointerstitial nephritis (HP:0001970)1.86034027
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.85880750
155Absent/shortened dynein arms (HP:0200106)1.85880750
156Pachygyria (HP:0001302)1.85680061
157Septo-optic dysplasia (HP:0100842)1.85163798
158Furrowed tongue (HP:0000221)1.84039108
159Ketoacidosis (HP:0001993)1.83917293
160Methylmalonic aciduria (HP:0012120)1.82785505
161Male pseudohermaphroditism (HP:0000037)1.82471937
162High anterior hairline (HP:0009890)1.82388830
163Anencephaly (HP:0002323)1.81932294
164Aplasia/Hypoplasia of the sternum (HP:0006714)1.81770317
165Preaxial hand polydactyly (HP:0001177)1.81636796
166Large for gestational age (HP:0001520)1.81605628
167Panhypogammaglobulinemia (HP:0003139)1.79879019
168Abnormality of chromosome segregation (HP:0002916)1.79210813
169Atresia of the external auditory canal (HP:0000413)1.78364907
170Focal seizures (HP:0007359)1.78053572
171Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77215325
172Abnormality of alanine metabolism (HP:0010916)1.77215325
173Hyperalaninemia (HP:0003348)1.77215325
174Oligodactyly (HP:0012165)1.76604780
175Inability to walk (HP:0002540)1.76197981
176Dialeptic seizures (HP:0011146)1.76137911
177Abnormality of the incisor (HP:0000676)1.75882281
178Lissencephaly (HP:0001339)1.75774985
179Dyskinesia (HP:0100660)1.72150641
180Narrow forehead (HP:0000341)1.71668398
181Sclerocornea (HP:0000647)1.71386420
182Dandy-Walker malformation (HP:0001305)1.70774609
183Excessive salivation (HP:0003781)1.70658692
184Oculomotor apraxia (HP:0000657)1.70042856
185Abnormality of the corticospinal tract (HP:0002492)1.68884252
186Hemiparesis (HP:0001269)1.68586539
187Mitochondrial inheritance (HP:0001427)1.67441648
188Abnormal mitochondria in muscle tissue (HP:0008316)1.66329668
189Congenital hepatic fibrosis (HP:0002612)1.64125077
190Fair hair (HP:0002286)1.64105425
191Astigmatism (HP:0000483)1.63359931
192Bony spicule pigmentary retinopathy (HP:0007737)1.63010943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.11865004
2FRK4.10603688
3WEE13.79888876
4BUB13.75496501
5PASK3.44713496
6NEK23.32303401
7TTK2.84305567
8SRPK12.81786936
9EIF2AK12.74882384
10MAP3K42.52320374
11CASK2.47754202
12PLK42.47438403
13PNCK2.43919955
14NEK12.36954439
15TRIM282.34043234
16MAP4K22.29739708
17ACVR1B2.28090042
18BRSK22.24906971
19PINK12.24598808
20PLK12.23864042
21WNK32.16473905
22NUAK12.14139303
23ATR2.04419932
24VRK12.01757083
25NTRK32.00931999
26TNIK1.97324608
27BMPR1B1.91897484
28TLK11.91539389
29CCNB11.89775840
30PLK31.88468982
31MAPK131.83078841
32MKNK11.80437751
33CHEK21.69660307
34AURKB1.69428141
35BCR1.68462867
36INSRR1.67445779
37BRSK11.64605183
38GRK11.59279366
39TSSK61.56768491
40MARK11.54685089
41DYRK31.53392812
42CDK71.52041565
43ZAK1.48619070
44RPS6KA41.48045305
45ADRBK21.44038525
46SCYL21.43026173
47AKT31.42512686
48MKNK21.42013267
49RPS6KB21.39614073
50CHEK11.39078905
51CDK121.38877814
52PAK31.37550330
53STK41.34178044
54STK391.33086786
55MAP2K71.32668195
56CDK81.29538687
57TAOK31.27837563
58STK101.27193914
59MUSK1.24947276
60CDK41.21567740
61AURKA1.18687312
62WNK41.15101138
63MST41.14323430
64ATM1.09776259
65NME21.09773645
66MAP3K81.09631812
67YES11.08539433
68CDK31.08444764
69STK161.07108318
70MELK1.06285212
71OXSR11.03722004
72EEF2K1.02676488
73TESK21.02449196
74EIF2AK31.00784921
75MAP4K11.00458041
76PRKCE1.00117402
77EPHA40.99381379
78TGFBR10.98683286
79CDK20.94175319
80CAMKK20.93524435
81PRKCG0.90732395
82TXK0.87156836
83CDK190.85194529
84PDK20.81178097
85CSNK1G20.79823474
86CDK10.79268950
87PIM10.78446727
88PAK40.71890432
89EPHA30.70816042
90STK30.69400500
91PKN20.68829154
92BRD40.68249801
93SIK30.67648653
94EIF2AK20.66810743
95OBSCN0.64181600
96CAMK2A0.63134836
97FGFR20.62898458
98MAP3K100.62799056
99PHKG20.62607948
100PHKG10.62607948
101RAF10.62233904
102NTRK20.60718456
103CSNK2A10.59822229
104BRAF0.59385133
105SGK20.58935394
106PBK0.56736129
107RPS6KA50.56313819
108PKN10.56021603
109CDK60.55106073
110MINK10.54773928
111NME10.53253908
112CSNK1G30.52498738
113CSNK2A20.51821853
114ZAP700.51063181
115MAPK150.49049485
116TIE10.47299301
117TEC0.47066796
118FLT30.46593425
119PRKACA0.44225705
120LRRK20.44063301
121BTK0.42999449
122DAPK20.42499634
123PRKDC0.39725006
124DYRK1A0.38529237
125IRAK40.37969291
126CSNK1A10.37573413
127ADRBK10.37551314
128NEK60.37454436
129PRKAA10.37353569
130MAP3K120.36394904
131STK38L0.36124904
132STK240.35739575
133SGK4940.35690697
134SGK2230.35690697
135CSNK1G10.35506457
136CSNK1D0.35398439
137ALK0.34312914
138PAK10.32863764
139MAPK140.32301895
140KSR10.32128625
141CSNK1A1L0.30654885
142ERBB20.28828120
143DYRK20.28579694
144PRKCI0.28427696
145ERBB30.27983211
146AKT10.25989853
147CDK90.25591677
148PLK20.23182280
149CLK10.22354829
150GSK3B0.22321483
151JAK30.22275238
152RPS6KB10.22012159
153GRK60.22005931
154AKT20.19731734
155CHUK0.19325467
156NEK90.16532332
157SIK20.15406793
158ERBB40.14339147
159FGFR10.14157982

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.61833334
2Mismatch repair_Homo sapiens_hsa034305.06107383
3Homologous recombination_Homo sapiens_hsa034403.87204195
4Base excision repair_Homo sapiens_hsa034103.50673044
5Cell cycle_Homo sapiens_hsa041103.17907671
6Spliceosome_Homo sapiens_hsa030403.17812087
7Fanconi anemia pathway_Homo sapiens_hsa034603.07212843
8Nucleotide excision repair_Homo sapiens_hsa034202.99388354
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97413727
10RNA transport_Homo sapiens_hsa030132.83045099
11Non-homologous end-joining_Homo sapiens_hsa034502.79787322
12Ribosome_Homo sapiens_hsa030102.72393508
13One carbon pool by folate_Homo sapiens_hsa006702.69796207
14RNA polymerase_Homo sapiens_hsa030202.67660450
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.58108782
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49266298
17Pyrimidine metabolism_Homo sapiens_hsa002402.42131564
18Proteasome_Homo sapiens_hsa030502.38532443
19Butanoate metabolism_Homo sapiens_hsa006502.27994342
20Propanoate metabolism_Homo sapiens_hsa006402.19094346
21Nicotine addiction_Homo sapiens_hsa050332.18359765
22RNA degradation_Homo sapiens_hsa030182.15943995
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06323007
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00906867
25mRNA surveillance pathway_Homo sapiens_hsa030151.89285217
26Caffeine metabolism_Homo sapiens_hsa002321.83233173
27Basal transcription factors_Homo sapiens_hsa030221.80414016
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.74505090
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61561719
30Oxidative phosphorylation_Homo sapiens_hsa001901.58732745
31p53 signaling pathway_Homo sapiens_hsa041151.58091970
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52829850
33Linoleic acid metabolism_Homo sapiens_hsa005911.50240060
34Regulation of autophagy_Homo sapiens_hsa041401.45649781
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45553166
36Tryptophan metabolism_Homo sapiens_hsa003801.43309428
37Fatty acid elongation_Homo sapiens_hsa000621.38162774
38Purine metabolism_Homo sapiens_hsa002301.36220676
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34518097
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33956129
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33557135
42Nitrogen metabolism_Homo sapiens_hsa009101.32984505
43Primary immunodeficiency_Homo sapiens_hsa053401.32217011
44Taste transduction_Homo sapiens_hsa047421.29388499
45Olfactory transduction_Homo sapiens_hsa047401.20937017
46Systemic lupus erythematosus_Homo sapiens_hsa053221.20442414
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20114452
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18957458
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16130126
50Insulin secretion_Homo sapiens_hsa049111.13555873
51Phototransduction_Homo sapiens_hsa047441.13515664
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12770507
53Peroxisome_Homo sapiens_hsa041461.12606824
54Retinol metabolism_Homo sapiens_hsa008301.11947815
55GABAergic synapse_Homo sapiens_hsa047271.11896315
56Oocyte meiosis_Homo sapiens_hsa041141.10492776
57beta-Alanine metabolism_Homo sapiens_hsa004101.09748522
58Ether lipid metabolism_Homo sapiens_hsa005651.08835507
59Epstein-Barr virus infection_Homo sapiens_hsa051691.05908796
60Chemical carcinogenesis_Homo sapiens_hsa052041.05353747
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04519885
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02911216
63Fatty acid degradation_Homo sapiens_hsa000711.02884314
64Morphine addiction_Homo sapiens_hsa050321.00460366
65Fatty acid metabolism_Homo sapiens_hsa012121.00098422
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.99035623
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96527951
68HTLV-I infection_Homo sapiens_hsa051660.95788112
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95187338
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94959276
71Glutamatergic synapse_Homo sapiens_hsa047240.89685560
72Amphetamine addiction_Homo sapiens_hsa050310.89584826
73Antigen processing and presentation_Homo sapiens_hsa046120.88730157
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88495499
75Viral carcinogenesis_Homo sapiens_hsa052030.88485156
76Herpes simplex infection_Homo sapiens_hsa051680.86678310
77Pyruvate metabolism_Homo sapiens_hsa006200.86617102
78Circadian entrainment_Homo sapiens_hsa047130.86475847
79Cardiac muscle contraction_Homo sapiens_hsa042600.83567936
80Steroid biosynthesis_Homo sapiens_hsa001000.82529530
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82467210
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79121617
83Vitamin B6 metabolism_Homo sapiens_hsa007500.73851263
84MicroRNAs in cancer_Homo sapiens_hsa052060.73227846
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73030700
86Cocaine addiction_Homo sapiens_hsa050300.72343202
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72308012
88Collecting duct acid secretion_Homo sapiens_hsa049660.71411702
89Dopaminergic synapse_Homo sapiens_hsa047280.69752447
90Serotonergic synapse_Homo sapiens_hsa047260.68562857
91Pentose phosphate pathway_Homo sapiens_hsa000300.68514042
92Basal cell carcinoma_Homo sapiens_hsa052170.67333420
93Alzheimers disease_Homo sapiens_hsa050100.64879764
94ABC transporters_Homo sapiens_hsa020100.63066120
95Colorectal cancer_Homo sapiens_hsa052100.61960666
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60748502
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58326326
98Arginine and proline metabolism_Homo sapiens_hsa003300.58254476
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56152475
100Biosynthesis of amino acids_Homo sapiens_hsa012300.53831049
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.52831258
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.52630638
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.52415429
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.52268368
105N-Glycan biosynthesis_Homo sapiens_hsa005100.51251941
106Synaptic vesicle cycle_Homo sapiens_hsa047210.50399598
107Alcoholism_Homo sapiens_hsa050340.50337346
108Notch signaling pathway_Homo sapiens_hsa043300.48803008
109Huntingtons disease_Homo sapiens_hsa050160.46916136
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46113896
111Protein export_Homo sapiens_hsa030600.45349188
112Hepatitis B_Homo sapiens_hsa051610.44869535
113Small cell lung cancer_Homo sapiens_hsa052220.41955716
114Measles_Homo sapiens_hsa051620.41863507
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40728480
116Hematopoietic cell lineage_Homo sapiens_hsa046400.40541361
117Folate biosynthesis_Homo sapiens_hsa007900.40337055
118Hippo signaling pathway_Homo sapiens_hsa043900.39895048
119Histidine metabolism_Homo sapiens_hsa003400.39854539
120Long-term depression_Homo sapiens_hsa047300.39514467
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38969618
122Thyroid cancer_Homo sapiens_hsa052160.38237856
123Ovarian steroidogenesis_Homo sapiens_hsa049130.38199548
124Calcium signaling pathway_Homo sapiens_hsa040200.38169005
125Renin secretion_Homo sapiens_hsa049240.37755083
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.37441923
127Hedgehog signaling pathway_Homo sapiens_hsa043400.37126902
128Arachidonic acid metabolism_Homo sapiens_hsa005900.36743522
129T cell receptor signaling pathway_Homo sapiens_hsa046600.35548003
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35476241
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34683429
132Lysine degradation_Homo sapiens_hsa003100.34663290
133TGF-beta signaling pathway_Homo sapiens_hsa043500.33542608
134Selenocompound metabolism_Homo sapiens_hsa004500.33102346
135Legionellosis_Homo sapiens_hsa051340.31138060
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30988969
137Pathways in cancer_Homo sapiens_hsa052000.27757612
138Prostate cancer_Homo sapiens_hsa052150.27002398
139Chronic myeloid leukemia_Homo sapiens_hsa052200.26992499
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26568221
141Apoptosis_Homo sapiens_hsa042100.24232435
142FoxO signaling pathway_Homo sapiens_hsa040680.23864236
143Pancreatic cancer_Homo sapiens_hsa052120.23517238
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23465313
145Wnt signaling pathway_Homo sapiens_hsa043100.22361529
146Acute myeloid leukemia_Homo sapiens_hsa052210.21953592
147HIF-1 signaling pathway_Homo sapiens_hsa040660.21543865
148Glutathione metabolism_Homo sapiens_hsa004800.21195278
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20708468
150Galactose metabolism_Homo sapiens_hsa000520.20349408
151Endometrial cancer_Homo sapiens_hsa052130.19851429
152Viral myocarditis_Homo sapiens_hsa054160.19586641
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19472922
154Carbon metabolism_Homo sapiens_hsa012000.19017056
155Parkinsons disease_Homo sapiens_hsa050120.15055462
156Fructose and mannose metabolism_Homo sapiens_hsa000510.14239197
157Non-small cell lung cancer_Homo sapiens_hsa052230.13644092
158Influenza A_Homo sapiens_hsa051640.11300948
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.10673660
160Metabolic pathways_Homo sapiens_hsa011000.08347564
161Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.08033654
162Adherens junction_Homo sapiens_hsa045200.07960756
163Melanoma_Homo sapiens_hsa052180.07343533
164NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06433870
165Circadian rhythm_Homo sapiens_hsa047100.05739605
166Shigellosis_Homo sapiens_hsa051310.04901927
167Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.03742660
168Allograft rejection_Homo sapiens_hsa053300.03651193

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