TUBG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.40280489
2DNA strand elongation (GO:0022616)5.12805347
3telomere maintenance via semi-conservative replication (GO:0032201)5.04135479
4DNA replication checkpoint (GO:0000076)5.01309202
5DNA replication initiation (GO:0006270)4.98625004
6DNA unwinding involved in DNA replication (GO:0006268)4.89885807
7nucleobase biosynthetic process (GO:0046112)4.88952849
8protein localization to kinetochore (GO:0034501)4.88478869
9purine nucleobase biosynthetic process (GO:0009113)4.63700091
10telomere maintenance via recombination (GO:0000722)4.46650890
11regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.44748129
12mitotic metaphase plate congression (GO:0007080)4.38472033
13mitotic sister chromatid segregation (GO:0000070)4.28061349
14mitotic recombination (GO:0006312)4.27263556
15DNA replication-dependent nucleosome organization (GO:0034723)4.20225351
16DNA replication-dependent nucleosome assembly (GO:0006335)4.20225351
17protein localization to chromosome, centromeric region (GO:0071459)4.13544381
18attachment of spindle microtubules to kinetochore (GO:0008608)4.10040134
19CENP-A containing nucleosome assembly (GO:0034080)3.95923253
20telomere maintenance via telomere lengthening (GO:0010833)3.94590902
21nucleotide-excision repair, DNA gap filling (GO:0006297)3.91385924
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.90426842
23cullin deneddylation (GO:0010388)3.84923280
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83247946
25mitotic nuclear envelope disassembly (GO:0007077)3.82732802
26chromatin remodeling at centromere (GO:0031055)3.82256575
27establishment of viral latency (GO:0019043)3.81797725
28protein deneddylation (GO:0000338)3.77555576
29sister chromatid segregation (GO:0000819)3.77157740
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76326576
31maturation of 5.8S rRNA (GO:0000460)3.75377974
32folic acid-containing compound biosynthetic process (GO:0009396)3.74978983
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.74838187
34DNA replication-independent nucleosome organization (GO:0034724)3.74240768
35DNA replication-independent nucleosome assembly (GO:0006336)3.74240768
36mitotic chromosome condensation (GO:0007076)3.72340002
37regulation of mitochondrial translation (GO:0070129)3.70857334
38metaphase plate congression (GO:0051310)3.67524390
39proteasome assembly (GO:0043248)3.67474623
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66540758
41kinetochore organization (GO:0051383)3.65941199
42formation of translation preinitiation complex (GO:0001731)3.62307092
43deoxyribonucleotide biosynthetic process (GO:0009263)3.62272616
44nuclear pore organization (GO:0006999)3.61289821
45DNA deamination (GO:0045006)3.57270101
46IMP biosynthetic process (GO:0006188)3.55125031
47membrane disassembly (GO:0030397)3.52290102
48nuclear envelope disassembly (GO:0051081)3.52290102
49kinetochore assembly (GO:0051382)3.51747648
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51022498
51cell cycle G1/S phase transition (GO:0044843)3.49396994
52G1/S transition of mitotic cell cycle (GO:0000082)3.49396994
53ribosome biogenesis (GO:0042254)3.49143672
54negative regulation of ligase activity (GO:0051352)3.48378944
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48378944
56protein maturation by protein folding (GO:0022417)3.46653130
57transcription-coupled nucleotide-excision repair (GO:0006283)3.42073461
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39932294
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39932294
60spliceosomal snRNP assembly (GO:0000387)3.38306425
61establishment of chromosome localization (GO:0051303)3.37176294
62nucleobase-containing small molecule interconversion (GO:0015949)3.36176181
63regulation of double-strand break repair via homologous recombination (GO:0010569)3.32981026
64regulation of spindle organization (GO:0090224)3.32439024
65histone exchange (GO:0043486)3.31147749
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30577552
67L-serine metabolic process (GO:0006563)3.30557720
68negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30288037
69establishment of integrated proviral latency (GO:0075713)3.29542430
70spindle checkpoint (GO:0031577)3.25893650
71negative regulation of chromosome segregation (GO:0051985)3.25136135
72regulation of cellular amino acid metabolic process (GO:0006521)3.23503541
73regulation of centrosome cycle (GO:0046605)3.23160655
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22399820
75negative regulation of sister chromatid segregation (GO:0033046)3.22399820
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.22399820
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22399820
78proline biosynthetic process (GO:0006561)3.19600253
79postreplication repair (GO:0006301)3.19158084
80spindle assembly checkpoint (GO:0071173)3.18104614
81maturation of SSU-rRNA (GO:0030490)3.18102399
82heterochromatin organization (GO:0070828)3.17738654
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.16966994
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16966994
85mitotic spindle assembly checkpoint (GO:0007094)3.16617524
86regulation of chromosome segregation (GO:0051983)3.15781271
87spliceosomal complex assembly (GO:0000245)3.15529717
88nuclear pore complex assembly (GO:0051292)3.13747568
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12843785
90regulation of translational fidelity (GO:0006450)3.12617100
91positive regulation of ligase activity (GO:0051351)3.12584656
92ribosome assembly (GO:0042255)3.12101963
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11680862
94positive regulation of chromosome segregation (GO:0051984)3.11635417
95chaperone-mediated protein transport (GO:0072321)3.10987272
96* mitotic cell cycle (GO:0000278)3.09996203
97chromosome segregation (GO:0007059)3.07933363
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06167315
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06167315
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05960049
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05960049
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05960049
103regulation of ubiquitin-protein transferase activity (GO:0051438)3.04961847
104signal transduction involved in DNA damage checkpoint (GO:0072422)3.04618219
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04618219
106signal transduction involved in cell cycle checkpoint (GO:0072395)3.04026478
1077-methylguanosine mRNA capping (GO:0006370)3.03494361
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02792113
109DNA ligation (GO:0006266)3.02727807
110regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02603841
111chromosome condensation (GO:0030261)2.97457139
112tRNA aminoacylation for protein translation (GO:0006418)2.96064611
113regulation of ligase activity (GO:0051340)2.93422272
114regulation of mitotic spindle organization (GO:0060236)2.92422472
115pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88721634
116nuclear envelope reassembly (GO:0031468)2.88520205
117mitotic nuclear envelope reassembly (GO:0007084)2.88520205
118base-excision repair (GO:0006284)2.87970353
119tRNA aminoacylation (GO:0043039)2.87561554
120amino acid activation (GO:0043038)2.87561554
121establishment of protein localization to mitochondrial membrane (GO:0090151)2.87438160
122mitotic spindle checkpoint (GO:0071174)2.78260591
123rRNA modification (GO:0000154)2.78017066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.04469624
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.40941009
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.14096365
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.03120877
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79834511
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70516944
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.36060280
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.26140548
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24741031
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.06056655
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05598843
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.03736279
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00479154
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86212554
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86091966
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85936052
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80014533
18XRN2_22483619_ChIP-Seq_HELA_Human2.56815689
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48343812
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41132457
21AR_21909140_ChIP-Seq_LNCAP_Human2.22131592
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19715325
23GABP_19822575_ChIP-Seq_HepG2_Human2.17417144
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13982990
25VDR_23849224_ChIP-Seq_CD4+_Human2.13616215
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10909040
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.10778364
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.04789270
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04284191
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01018437
31FOXP3_21729870_ChIP-Seq_TREG_Human1.99774706
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.97808678
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95136643
34* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93241377
35TTF2_22483619_ChIP-Seq_HELA_Human1.88049990
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85001568
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79882967
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78140903
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74397301
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73960618
41CIITA_25753668_ChIP-Seq_RAJI_Human1.69784155
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67809339
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64300497
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63046665
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62240580
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.61970369
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60416448
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59571641
49KDM5A_27292631_Chip-Seq_BREAST_Human1.57687207
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57141159
51ZNF263_19887448_ChIP-Seq_K562_Human1.48507121
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44686343
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36925724
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36484403
55ELK1_19687146_ChIP-ChIP_HELA_Human1.36256643
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33042552
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30816674
58MYC_22102868_ChIP-Seq_BL_Human1.28826955
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28538778
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.25307426
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23723870
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22906678
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22009948
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20048478
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19833118
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19593160
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17995988
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16592533
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15591978
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.15448986
71TFEB_21752829_ChIP-Seq_HELA_Human1.14666617
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11834738
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08078304
74* SOX17_20123909_ChIP-Seq_XEN_Mouse1.07926105
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07225997
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07101211
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06935238
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06692955
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05348435
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04862940
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03917714
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02999924
83* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02823843
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02612130
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02126880
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98351085
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98088761
88MYC_18940864_ChIP-ChIP_HL60_Human0.97865257
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96937102
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92839850
91TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90088211
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89613734
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89108458
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88548923
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86249802
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85861284
97HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85600067
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85184551
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84093588
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83307866
101CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83113820
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.82921220
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82257348
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.80588359
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75942187
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75623719
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75447739
108FOXP1_21924763_ChIP-Seq_HESCs_Human0.74370768
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74155810
110VDR_21846776_ChIP-Seq_THP-1_Human0.74126154
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73555884
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71122118
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70794916
114* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.70358084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.81111974
2MP0010094_abnormal_chromosome_stability5.18131789
3MP0003111_abnormal_nucleus_morphology5.01581087
4MP0004957_abnormal_blastocyst_morpholog4.61368611
5* MP0003077_abnormal_cell_cycle4.25919549
6MP0008057_abnormal_DNA_replication3.99335369
7MP0008058_abnormal_DNA_repair3.67287165
8MP0008932_abnormal_embryonic_tissue3.14356333
9MP0008877_abnormal_DNA_methylation3.13237716
10MP0003123_paternal_imprinting3.09198511
11MP0008007_abnormal_cellular_replicative2.84164406
12* MP0001730_embryonic_growth_arrest2.71387106
13MP0000350_abnormal_cell_proliferation2.30989527
14MP0003121_genomic_imprinting2.22570566
15MP0003786_premature_aging2.00567416
16MP0001697_abnormal_embryo_size1.86698668
17MP0010030_abnormal_orbit_morphology1.85303828
18MP0003718_maternal_effect1.80915518
19MP0005380_embryogenesis_phenotype1.80431888
20MP0001672_abnormal_embryogenesis/_devel1.80431888
21MP0000372_irregular_coat_pigmentation1.74644157
22* MP0002080_prenatal_lethality1.70278519
23MP0003890_abnormal_embryonic-extraembry1.70004037
24MP0003122_maternal_imprinting1.66376953
25MP0003984_embryonic_growth_retardation1.63881610
26MP0002396_abnormal_hematopoietic_system1.58966217
27MP0002088_abnormal_embryonic_growth/wei1.58461179
28MP0002085_abnormal_embryonic_tissue1.57869548
29MP0002877_abnormal_melanocyte_morpholog1.50866759
30MP0001529_abnormal_vocalization1.49745855
31MP0005408_hypopigmentation1.41676845
32MP0000313_abnormal_cell_death1.41289658
33MP0001346_abnormal_lacrimal_gland1.40841398
34MP0002084_abnormal_developmental_patter1.36601297
35MP0005623_abnormal_meninges_morphology1.35300000
36MP0006292_abnormal_olfactory_placode1.33454937
37MP0002210_abnormal_sex_determination1.33378158
38MP0003941_abnormal_skin_development1.31412541
39MP0002653_abnormal_ependyma_morphology1.28172465
40MP0003806_abnormal_nucleotide_metabolis1.27722330
41MP0003119_abnormal_digestive_system1.24687082
42MP0009672_abnormal_birth_weight1.22785138
43MP0003567_abnormal_fetal_cardiomyocyte1.22710823
44MP0003136_yellow_coat_color1.22384559
45MP0000358_abnormal_cell_content/1.20874935
46MP0004197_abnormal_fetal_growth/weight/1.20666607
47MP0010307_abnormal_tumor_latency1.18744506
48MP0002019_abnormal_tumor_incidence1.18080448
49MP0003221_abnormal_cardiomyocyte_apopto1.16257851
50MP0002160_abnormal_reproductive_system1.15977097
51MP0002086_abnormal_extraembryonic_tissu1.14876562
52MP0001661_extended_life_span1.13089771
53MP0003315_abnormal_perineum_morphology1.11233092
54MP0001145_abnormal_male_reproductive1.11042075
55MP0010352_gastrointestinal_tract_polyps1.09821774
56MP0006036_abnormal_mitochondrial_physio1.08195478
57MP0005501_abnormal_skin_physiology1.07205135
58MP0005076_abnormal_cell_differentiation1.01171268
59MP0000537_abnormal_urethra_morphology1.00591253
60MP0003950_abnormal_plasma_membrane1.00137430
61MP0006035_abnormal_mitochondrial_morpho0.98158302
62MP0002697_abnormal_eye_size0.97875347
63MP0002163_abnormal_gland_morphology0.97213728
64MP0000490_abnormal_crypts_of0.96899551
65MP0001293_anophthalmia0.96857639
66MP0003646_muscle_fatigue0.96271519
67MP0004272_abnormal_basement_membrane0.94509267
68MP0009053_abnormal_anal_canal0.94438765
69MP0005171_absent_coat_pigmentation0.94172656
70MP0002234_abnormal_pharynx_morphology0.94130543
71MP0001929_abnormal_gametogenesis0.92846634
72MP0000653_abnormal_sex_gland0.92611735
73MP0003656_abnormal_erythrocyte_physiolo0.92506732
74MP0003787_abnormal_imprinting0.92472081
75MP0000049_abnormal_middle_ear0.92469117
76MP0005257_abnormal_intraocular_pressure0.91427078
77MP0005384_cellular_phenotype0.90117066
78MP0000750_abnormal_muscle_regeneration0.89970425
79MP0008789_abnormal_olfactory_epithelium0.89671404
80MP0002269_muscular_atrophy0.89403559
81MP0005266_abnormal_metabolism0.88701367
82MP0004808_abnormal_hematopoietic_stem0.85508854
83MP0009697_abnormal_copulation0.84288326
84MP0001119_abnormal_female_reproductive0.81958420
85MP0002751_abnormal_autonomic_nervous0.81608012
86MP0002233_abnormal_nose_morphology0.80648891
87MP0005389_reproductive_system_phenotype0.80431973
88MP0002111_abnormal_tail_morphology0.79971308
89MP0001299_abnormal_eye_distance/0.78413857
90MP0009333_abnormal_splenocyte_physiolog0.78145596
91MP0003698_abnormal_male_reproductive0.77657659
92MP0000762_abnormal_tongue_morphology0.77514787
93MP0004233_abnormal_muscle_weight0.77190422
94MP0008260_abnormal_autophagy0.75862766
95MP0005330_cardiomyopathy0.75143375
96MP0002177_abnormal_outer_ear0.74706832
97MP0002102_abnormal_ear_morphology0.73770988
98MP0005621_abnormal_cell_physiology0.73298514
99MP0000749_muscle_degeneration0.71995666
100MP0003755_abnormal_palate_morphology0.71401857
101MP0003385_abnormal_body_wall0.70998640
102MP0004084_abnormal_cardiac_muscle0.70734436
103MP0005083_abnormal_biliary_tract0.70618622
104MP0002249_abnormal_larynx_morphology0.70453301
105MP0004147_increased_porphyrin_level0.69992907
106MP0003186_abnormal_redox_activity0.68021697
107MP0003566_abnormal_cell_adhesion0.67936988
108MP0005379_endocrine/exocrine_gland_phen0.66499843
109MP0009703_decreased_birth_body0.65757835
110MP0005499_abnormal_olfactory_system0.65721760
111MP0005394_taste/olfaction_phenotype0.65721760
112MP0003937_abnormal_limbs/digits/tail_de0.65438110
113MP0002092_abnormal_eye_morphology0.64750389
114MP0000703_abnormal_thymus_morphology0.64404054
115MP0003115_abnormal_respiratory_system0.62505529
116MP0001764_abnormal_homeostasis0.61952690
117MP0003861_abnormal_nervous_system0.61711182
118MP0002127_abnormal_cardiovascular_syste0.61095411
119MP0005397_hematopoietic_system_phenotyp0.60539391
120MP0001545_abnormal_hematopoietic_system0.60539391
121MP0000566_synostosis0.60106973
122MP0003942_abnormal_urinary_system0.58923252
123MP0001727_abnormal_embryo_implantation0.58202265
124MP0002970_abnormal_white_adipose0.57287882
125MP0004133_heterotaxia0.56767655
126MP0001919_abnormal_reproductive_system0.54593340
127MP0000678_abnormal_parathyroid_gland0.53150918
128MP0001286_abnormal_eye_development0.52521907
129MP0002161_abnormal_fertility/fecundity0.52511019
130MP0002938_white_spotting0.52070643

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.84625552
2Breast hypoplasia (HP:0003187)4.75618946
3Patellar aplasia (HP:0006443)4.34076454
4Aplasia/Hypoplasia of the patella (HP:0006498)4.03400487
5Chromsome breakage (HP:0040012)3.80269296
6Abnormal gallbladder physiology (HP:0012438)3.70490740
7Cholecystitis (HP:0001082)3.70490740
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61035071
9Carpal bone hypoplasia (HP:0001498)3.54747930
10Hypoplasia of the capital femoral epiphysis (HP:0003090)3.39420507
11Abnormality of the anterior horn cell (HP:0006802)3.37489651
12Degeneration of anterior horn cells (HP:0002398)3.37489651
13Oral leukoplakia (HP:0002745)3.31278485
14Cerebral hypomyelination (HP:0006808)3.30487930
15Ependymoma (HP:0002888)3.18334542
16Meckel diverticulum (HP:0002245)3.11228752
17Increased serum pyruvate (HP:0003542)3.08734738
18Abnormality of glycolysis (HP:0004366)3.08734738
19Impulsivity (HP:0100710)3.08664608
20Abnormality of the ileum (HP:0001549)3.00742021
21Rough bone trabeculation (HP:0100670)2.99351764
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96935227
23Abnormality of chromosome stability (HP:0003220)2.94344101
24Abnormality of the labia minora (HP:0012880)2.88757988
25Selective tooth agenesis (HP:0001592)2.87477972
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.87181033
27Microretrognathia (HP:0000308)2.86659037
28Abnormality of the preputium (HP:0100587)2.83001639
29Microvesicular hepatic steatosis (HP:0001414)2.82752976
30Increased serum lactate (HP:0002151)2.59693100
31Duodenal stenosis (HP:0100867)2.57239975
32Small intestinal stenosis (HP:0012848)2.57239975
33Colon cancer (HP:0003003)2.55489633
34Reticulocytopenia (HP:0001896)2.54580004
35Medulloblastoma (HP:0002885)2.54559367
36Aplastic anemia (HP:0001915)2.54402634
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52902070
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52046160
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52046160
40Type I transferrin isoform profile (HP:0003642)2.48596279
41Slender long bone (HP:0003100)2.45916884
42Premature graying of hair (HP:0002216)2.45853500
43Absent epiphyses (HP:0010577)2.44561385
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.44561385
45Hepatocellular necrosis (HP:0001404)2.42909509
46Premature ovarian failure (HP:0008209)2.36939874
47Acute necrotizing encephalopathy (HP:0006965)2.34710947
48Secondary amenorrhea (HP:0000869)2.33586353
49Cortical dysplasia (HP:0002539)2.32601388
50Horseshoe kidney (HP:0000085)2.32400130
51Abnormal trabecular bone morphology (HP:0100671)2.32230174
52Absent radius (HP:0003974)2.30759677
53Megaloblastic anemia (HP:0001889)2.30094181
54Increased CSF lactate (HP:0002490)2.29364676
55Abnormal number of erythroid precursors (HP:0012131)2.29303295
56Hypoplastic pelvis (HP:0008839)2.29222583
57Abnormal mitochondria in muscle tissue (HP:0008316)2.28268313
58Bone marrow hypocellularity (HP:0005528)2.25833468
59Agnosia (HP:0010524)2.22973195
60Hepatic necrosis (HP:0002605)2.21742773
61Facial cleft (HP:0002006)2.21042227
62Proximal placement of thumb (HP:0009623)2.20956041
63Abnormality of the umbilical cord (HP:0010881)2.20867798
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.20367844
65Prominent metopic ridge (HP:0005487)2.19399802
66Abnormal lung lobation (HP:0002101)2.18333807
67Neoplasm of the pancreas (HP:0002894)2.18240282
68Testicular atrophy (HP:0000029)2.16725104
69Abnormality of the duodenum (HP:0002246)2.16610603
70Multiple enchondromatosis (HP:0005701)2.16352211
71Abnormal protein glycosylation (HP:0012346)2.16009587
72Abnormal glycosylation (HP:0012345)2.16009587
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16009587
74Abnormal protein N-linked glycosylation (HP:0012347)2.16009587
75Abnormality of cells of the erythroid lineage (HP:0012130)2.15873701
76Sloping forehead (HP:0000340)2.14472341
77Cerebral edema (HP:0002181)2.14143203
78Mitochondrial inheritance (HP:0001427)2.13925225
79Aplasia involving forearm bones (HP:0009822)2.12155888
80Absent forearm bone (HP:0003953)2.12155888
81Cholelithiasis (HP:0001081)2.08983535
82Unsteady gait (HP:0002317)2.06850680
83Progressive macrocephaly (HP:0004481)2.06775009
84Increased nuchal translucency (HP:0010880)2.06734420
85Deviation of the thumb (HP:0009603)2.04362060
86Sparse eyelashes (HP:0000653)2.03642282
87Breast aplasia (HP:0100783)2.02787065
88Microglossia (HP:0000171)2.02455657
89Adenoma sebaceum (HP:0009720)2.01524714
90Angiofibromas (HP:0010615)2.01524714
9111 pairs of ribs (HP:0000878)2.01426911
92Emotional lability (HP:0000712)2.00570073
93Abnormal number of incisors (HP:0011064)1.99451871
94Abnormality of the astrocytes (HP:0100707)1.99273409
95Astrocytoma (HP:0009592)1.99273409
96Aplasia/Hypoplasia of the breasts (HP:0010311)1.99181588
97Abnormality of the carotid arteries (HP:0005344)1.98875631
98Abnormality of pyrimidine metabolism (HP:0004353)1.98861589
99Abnormality of the metopic suture (HP:0005556)1.98281252
100Cafe-au-lait spot (HP:0000957)1.96584425
101Atrophy/Degeneration involving motor neurons (HP:0007373)1.96533251
102Progressive muscle weakness (HP:0003323)1.96079281
103Absent thumb (HP:0009777)1.95744563
104Trismus (HP:0000211)1.95253632
105Myelodysplasia (HP:0002863)1.94490909
106Tracheoesophageal fistula (HP:0002575)1.93631065
107Abnormal umbilical cord blood vessels (HP:0011403)1.93363716
108Single umbilical artery (HP:0001195)1.93363716
109Abnormality of the fetal cardiovascular system (HP:0010948)1.93363716
110Abnormal gallbladder morphology (HP:0012437)1.92977219
111Gout (HP:0001997)1.92834882
112Squamous cell carcinoma (HP:0002860)1.90141520
113Rhabdomyosarcoma (HP:0002859)1.89500730
114Irregular epiphyses (HP:0010582)1.88054855
115Glioma (HP:0009733)1.87500903
116Upper limb muscle weakness (HP:0003484)1.87259191
117Reduced antithrombin III activity (HP:0001976)1.87097375
118Triphalangeal thumb (HP:0001199)1.86929707
119Hypoplasia of the pons (HP:0012110)1.86806107
120Abnormality of reticulocytes (HP:0004312)1.86549577
121Abnormalities of placenta or umbilical cord (HP:0001194)1.83795918
122Optic nerve coloboma (HP:0000588)1.82656055
123Macrocytic anemia (HP:0001972)1.81699901
124Ectopic kidney (HP:0000086)1.81552702
125Postnatal microcephaly (HP:0005484)1.81420781
126Hypokinesia (HP:0002375)1.80436928
127Increased hepatocellular lipid droplets (HP:0006565)1.80090112
128High anterior hairline (HP:0009890)1.79997700
129Cellular immunodeficiency (HP:0005374)1.78775370
130Cutaneous melanoma (HP:0012056)1.78182010
131Atresia of the external auditory canal (HP:0000413)1.78123608
132Ragged-red muscle fibers (HP:0003200)1.77268270
133Acute encephalopathy (HP:0006846)1.76834913
134Exercise intolerance (HP:0003546)1.75429246
135Nephroblastoma (Wilms tumor) (HP:0002667)1.72837448
136Entropion (HP:0000621)1.71857760
137Abnormality of the gallbladder (HP:0005264)1.71138682
138Lactic acidosis (HP:0003128)1.68219991
139Opisthotonus (HP:0002179)1.66444911
140Respiratory failure (HP:0002878)1.65502343
141Lipid accumulation in hepatocytes (HP:0006561)1.64701211
142Embryonal renal neoplasm (HP:0011794)1.60273205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.36705657
2WEE14.34968527
3CDC74.22699294
4EIF2AK13.95747938
5VRK23.89964874
6NEK13.65506568
7ACVR1B3.29471997
8PLK42.80060040
9TSSK62.71462523
10CCNB12.64440985
11NEK22.59512541
12BRSK22.53653362
13TESK22.30385217
14EIF2AK32.21737520
15PLK12.06837293
16SRPK11.99522433
17STK161.92391410
18TRIM281.76901329
19TTK1.73013039
20SMG11.70578880
21PLK31.68119733
22VRK11.63511726
23* BRSK11.49513076
24AURKA1.48774184
25ATR1.48180540
26TAF11.47985135
27AURKB1.44495038
28CDK71.38943266
29PDK21.38795196
30RPS6KA41.34063183
31NME21.29158000
32MAP3K111.26012809
33CHEK21.22937713
34MST1R1.21859061
35PASK1.20728245
36STK38L1.16570197
37TESK11.15354342
38BRAF1.15088364
39CDK81.12322911
40EEF2K1.11255521
41IRAK31.11130442
42CSNK1G31.10910606
43PAK41.10582466
44CHEK11.06980793
45LATS21.06709928
46TLK11.06258889
47CDK41.02083051
48SIK30.99609725
49LIMK10.99131675
50TGFBR10.97311466
51MKNK10.93613002
52MAP3K80.91318306
53CSNK1A1L0.90175991
54PBK0.87828624
55CSNK1G10.82802701
56RPS6KB20.81525635
57MET0.80549569
58DYRK30.78472637
59MST40.78127907
60ZAK0.77812762
61MAPKAPK30.74802518
62EIF2AK20.74491882
63ICK0.73966123
64EPHA20.73059302
65* CDK20.72097533
66ERBB40.71920270
67PIM20.71916952
68CDK120.69252388
69PAK10.69026639
70CSNK1G20.68790746
71MAP3K120.68530687
72DAPK10.67513355
73NUAK10.66685788
74ATM0.66229993
75STK40.65682162
76BCR0.65136801
77PRKD30.63841836
78PTK20.63247515
79ARAF0.61858202
80KDR0.60986014
81CSNK2A10.60901546
82STK100.60452251
83AKT30.58172260
84CDK10.57919372
85MELK0.57831330
86CDK180.56878408
87ILK0.56118354
88SCYL20.55508408
89CSNK2A20.53525710
90NME10.52887111
91DYRK20.52651452
92CDK150.52182019
93BCKDK0.52114526
94CDK11A0.49844600
95CDK140.49275562
96PLK20.47077529
97WNK40.46880590
98MAP2K70.44753218
99UHMK10.44492632
100TRIB30.43803928
101CDK90.40984807
102MKNK20.39002319
103LMTK20.38271947
104PRKCI0.37484505
105AKT20.33680138
106TAOK20.32314664
107CLK10.32298101
108FGFR10.29497690
109MAPKAPK50.28766505
110MINK10.26307761
111RPS6KC10.26066954
112RPS6KL10.26066954
113ABL20.23727610
114RPS6KA50.22343097
115CSNK1E0.21500859
116PIM10.20697296
117RPS6KA60.20381826
118RAF10.19382130
119BMPR1B0.19340142
120MAPKAPK20.19188768
121PNCK0.18842560
122MAPK110.18577821
123OBSCN0.18565040
124LRRK20.17019833
125STK240.16660382
126WNK30.15697217
127CDK60.15393493

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.46017407
2Mismatch repair_Homo sapiens_hsa034304.54252397
3Proteasome_Homo sapiens_hsa030504.14189319
4Base excision repair_Homo sapiens_hsa034103.32581405
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31782757
6RNA polymerase_Homo sapiens_hsa030203.19854392
7Spliceosome_Homo sapiens_hsa030403.18150621
8Cell cycle_Homo sapiens_hsa041103.10697558
9Homologous recombination_Homo sapiens_hsa034403.04456382
10RNA transport_Homo sapiens_hsa030133.03354949
11Nucleotide excision repair_Homo sapiens_hsa034202.95665972
12Pyrimidine metabolism_Homo sapiens_hsa002402.64984642
13One carbon pool by folate_Homo sapiens_hsa006702.60441109
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41048624
15Ribosome_Homo sapiens_hsa030102.34567363
16Fanconi anemia pathway_Homo sapiens_hsa034601.97592985
17Non-homologous end-joining_Homo sapiens_hsa034501.88366826
18Fatty acid elongation_Homo sapiens_hsa000621.81745272
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80469969
20Basal transcription factors_Homo sapiens_hsa030221.77661859
21RNA degradation_Homo sapiens_hsa030181.76493537
22mRNA surveillance pathway_Homo sapiens_hsa030151.54994232
23p53 signaling pathway_Homo sapiens_hsa041151.47873548
24Biosynthesis of amino acids_Homo sapiens_hsa012301.46844074
25Purine metabolism_Homo sapiens_hsa002301.43200615
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39667124
27Steroid biosynthesis_Homo sapiens_hsa001001.33791438
28Parkinsons disease_Homo sapiens_hsa050121.31842885
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.30489476
30Oocyte meiosis_Homo sapiens_hsa041141.24895924
31Oxidative phosphorylation_Homo sapiens_hsa001901.20510331
32Huntingtons disease_Homo sapiens_hsa050161.18812761
33Epstein-Barr virus infection_Homo sapiens_hsa051691.16995227
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14837311
35Vitamin B6 metabolism_Homo sapiens_hsa007501.12143882
36Carbon metabolism_Homo sapiens_hsa012001.09207548
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05728072
38Propanoate metabolism_Homo sapiens_hsa006401.02015957
39Pentose phosphate pathway_Homo sapiens_hsa000300.99979723
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94644040
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92573502
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.90417192
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84473475
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83512268
45Fatty acid metabolism_Homo sapiens_hsa012120.81264867
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76852732
47Folate biosynthesis_Homo sapiens_hsa007900.76581044
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74060445
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.72831727
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72242479
51Viral carcinogenesis_Homo sapiens_hsa052030.69796485
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67406254
53Fructose and mannose metabolism_Homo sapiens_hsa000510.64087988
54Protein export_Homo sapiens_hsa030600.63631508
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62145805
56Pyruvate metabolism_Homo sapiens_hsa006200.60170145
57HTLV-I infection_Homo sapiens_hsa051660.55282907
58Systemic lupus erythematosus_Homo sapiens_hsa053220.54427777
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52352458
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52274364
61Arginine biosynthesis_Homo sapiens_hsa002200.52106211
62Thyroid cancer_Homo sapiens_hsa052160.51025805
63Selenocompound metabolism_Homo sapiens_hsa004500.50215052
64Lysine degradation_Homo sapiens_hsa003100.48897898
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47697713
66Alzheimers disease_Homo sapiens_hsa050100.46151357
67Glutathione metabolism_Homo sapiens_hsa004800.46134096
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44012201
69N-Glycan biosynthesis_Homo sapiens_hsa005100.43048371
70Metabolic pathways_Homo sapiens_hsa011000.39676944
71Herpes simplex infection_Homo sapiens_hsa051680.39359262
72Sulfur metabolism_Homo sapiens_hsa009200.36933299
73Regulation of autophagy_Homo sapiens_hsa041400.35036994
74Bladder cancer_Homo sapiens_hsa052190.33886799
75Shigellosis_Homo sapiens_hsa051310.33595597
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30370858
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29972143
78Cardiac muscle contraction_Homo sapiens_hsa042600.29881164
79Hippo signaling pathway_Homo sapiens_hsa043900.29765248
80Sulfur relay system_Homo sapiens_hsa041220.29218289
81Galactose metabolism_Homo sapiens_hsa000520.28926558
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28473477
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28406649
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27925498
85Peroxisome_Homo sapiens_hsa041460.27299683
86Fatty acid degradation_Homo sapiens_hsa000710.27238552
87Colorectal cancer_Homo sapiens_hsa052100.26545952
88Butanoate metabolism_Homo sapiens_hsa006500.26252512
89Antigen processing and presentation_Homo sapiens_hsa046120.25735137
90Alcoholism_Homo sapiens_hsa050340.24461500
91MicroRNAs in cancer_Homo sapiens_hsa052060.22658165
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.21232123
93Fat digestion and absorption_Homo sapiens_hsa049750.20589445
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20034512
95Arginine and proline metabolism_Homo sapiens_hsa003300.19673914
96Fatty acid biosynthesis_Homo sapiens_hsa000610.17324135
97Small cell lung cancer_Homo sapiens_hsa052220.16733630
98Legionellosis_Homo sapiens_hsa051340.15744150
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15011570
100Wnt signaling pathway_Homo sapiens_hsa043100.13304788
101beta-Alanine metabolism_Homo sapiens_hsa004100.12748417
102HIF-1 signaling pathway_Homo sapiens_hsa040660.12144872
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11238207
104Apoptosis_Homo sapiens_hsa042100.09852103
105Vibrio cholerae infection_Homo sapiens_hsa051100.09676133
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09408612
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08971355
108Hepatitis B_Homo sapiens_hsa051610.08114804
109Vitamin digestion and absorption_Homo sapiens_hsa049770.06607604
110TGF-beta signaling pathway_Homo sapiens_hsa043500.04414918
111Hedgehog signaling pathway_Homo sapiens_hsa043400.03089120
112Phenylalanine metabolism_Homo sapiens_hsa003600.02778295
113Pancreatic cancer_Homo sapiens_hsa052120.02376768
114Melanoma_Homo sapiens_hsa052180.00656058
115Tyrosine metabolism_Homo sapiens_hsa003500.00435994
116Chronic myeloid leukemia_Homo sapiens_hsa052200.00333307
117Basal cell carcinoma_Homo sapiens_hsa052170.00182120
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0132456
119Non-small cell lung cancer_Homo sapiens_hsa05223-0.0090214
120Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0081205
121Adherens junction_Homo sapiens_hsa04520-0.0047283
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0025923

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