TUBG1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)6.21496078
2proteasome assembly (GO:0043248)5.86252280
3ATP synthesis coupled proton transport (GO:0015986)5.34134178
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.34134178
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.57468876
6CENP-A containing nucleosome assembly (GO:0034080)4.46117269
7GDP-mannose metabolic process (GO:0019673)4.44979926
8DNA strand elongation involved in DNA replication (GO:0006271)4.44137745
9chromatin remodeling at centromere (GO:0031055)4.42442911
10inner mitochondrial membrane organization (GO:0007007)4.31063162
11mitotic nuclear envelope reassembly (GO:0007084)4.17982047
12nuclear envelope reassembly (GO:0031468)4.17982047
13DNA strand elongation (GO:0022616)4.09473754
14chaperone-mediated protein transport (GO:0072321)4.06138550
15viral transcription (GO:0019083)4.02442299
16ribosomal small subunit assembly (GO:0000028)4.00881156
17response to insecticide (GO:0017085)4.00111556
18histone mRNA catabolic process (GO:0071044)3.99099565
19histone exchange (GO:0043486)3.99025078
20translational termination (GO:0006415)3.96235674
21translesion synthesis (GO:0019985)3.93331066
22DNA strand renaturation (GO:0000733)3.91164394
23DNA replication initiation (GO:0006270)3.91141220
24intra-S DNA damage checkpoint (GO:0031573)3.88828302
25alkaloid metabolic process (GO:0009820)3.86586154
26telomere maintenance via semi-conservative replication (GO:0032201)3.74667091
27positive regulation of protein kinase C signaling (GO:0090037)3.74498107
28microtubule depolymerization (GO:0007019)3.65700922
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.62892344
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.62844181
31negative regulation of translation, ncRNA-mediated (GO:0040033)3.51806765
32regulation of translation, ncRNA-mediated (GO:0045974)3.51806765
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.51806765
34cellular response to oxygen radical (GO:0071450)3.41064271
35removal of superoxide radicals (GO:0019430)3.41064271
36cellular response to superoxide (GO:0071451)3.41064271
37DNA replication-independent nucleosome assembly (GO:0006336)3.34883049
38DNA replication-independent nucleosome organization (GO:0034724)3.34883049
39translational elongation (GO:0006414)3.33845766
40telomere maintenance via recombination (GO:0000722)3.32727910
41estrogen biosynthetic process (GO:0006703)3.29826095
42ribosomal large subunit biogenesis (GO:0042273)3.29472693
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29183663
44rRNA catabolic process (GO:0016075)3.28739559
45telomere maintenance via telomere lengthening (GO:0010833)3.23198105
46cGMP biosynthetic process (GO:0006182)3.22303687
47translational initiation (GO:0006413)3.21705225
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.20378605
49cellular protein complex disassembly (GO:0043624)3.20015668
50cotranslational protein targeting to membrane (GO:0006613)3.19773651
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15798995
52protein targeting to ER (GO:0045047)3.12576480
53regulation of appetite (GO:0032098)3.09588529
54viral mRNA export from host cell nucleus (GO:0046784)3.09488855
55adult feeding behavior (GO:0008343)3.06215329
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01590749
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01590749
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01590749
59protein complex disassembly (GO:0043241)3.00325753
60pseudouridine synthesis (GO:0001522)3.00207745
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99712803
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99562522
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99562522
64protein K6-linked ubiquitination (GO:0085020)2.98454268
65establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96644294
66serine family amino acid catabolic process (GO:0009071)2.96625106
67somatic hypermutation of immunoglobulin genes (GO:0016446)2.96196507
68somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96196507
69dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.94656083
70signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91658989
71signal transduction involved in DNA damage checkpoint (GO:0072422)2.91658989
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.91249418
73macromolecular complex disassembly (GO:0032984)2.86951299
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86774864
75termination of RNA polymerase III transcription (GO:0006386)2.85312980
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.85312980
77mitotic recombination (GO:0006312)2.85085286
78signal transduction involved in cell cycle checkpoint (GO:0072395)2.82696753
79protein localization to endoplasmic reticulum (GO:0070972)2.81388697
80ATP biosynthetic process (GO:0006754)2.80402211
81prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.79531321
82rRNA methylation (GO:0031167)2.78200265
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78074390
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78060498
85viral life cycle (GO:0019058)2.77572530
86DNA replication checkpoint (GO:0000076)2.77295425
87DNA biosynthetic process (GO:0071897)2.75204789
88DNA ligation (GO:0006266)2.75096209
89histone mRNA metabolic process (GO:0008334)2.74946428
90organelle disassembly (GO:1903008)2.74109881
91DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.72936255
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71624488
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.71624488
94NADH dehydrogenase complex assembly (GO:0010257)2.71624488
95ATP-dependent chromatin remodeling (GO:0043044)2.70588201
96regulation of cellular amino acid metabolic process (GO:0006521)2.69703248
97serotonin metabolic process (GO:0042428)2.69514883
98nucleoside transmembrane transport (GO:1901642)2.68759047
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68589926
100branching involved in labyrinthine layer morphogenesis (GO:0060670)2.68199560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.08221154
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.72121330
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.30606623
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10247587
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.97504552
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48111727
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.03785768
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01641705
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92073676
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86303532
11XRN2_22483619_ChIP-Seq_HELA_Human2.72708714
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.68573043
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58940493
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.56122119
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.55293148
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50765394
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17698879
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15463323
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13167776
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.10272844
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03779094
22POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01929961
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99178173
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96391917
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94094637
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.93267637
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.92856895
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89557429
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87479388
30VDR_23849224_ChIP-Seq_CD4+_Human1.84749855
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79171733
32KDM5A_27292631_Chip-Seq_BREAST_Human1.77198843
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73092826
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70367916
35TTF2_22483619_ChIP-Seq_HELA_Human1.68459197
36AR_21909140_ChIP-Seq_LNCAP_Human1.66399231
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65770651
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64671261
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63412923
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.61006504
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58998238
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57736358
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56384256
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56274413
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52703138
46GABP_19822575_ChIP-Seq_HepG2_Human1.48960052
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45923733
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45923733
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45923733
50DCP1A_22483619_ChIP-Seq_HELA_Human1.45500783
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41440527
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.40686602
53SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38089294
54MYC_18940864_ChIP-ChIP_HL60_Human1.37594379
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.37377660
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35646462
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34869525
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31113781
59FOXP3_21729870_ChIP-Seq_TREG_Human1.31057844
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29922714
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26393386
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25690213
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25140758
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23624824
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23611770
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20728733
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20332135
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.19939082
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.18586516
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.18263993
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15021155
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13911213
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10016617
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07901493
75ELK1_19687146_ChIP-ChIP_HELA_Human1.07621917
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06799162
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06695339
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06422626
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05094455
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03331153
81RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02983321
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02432588
83MAF_26560356_Chip-Seq_TH2_Human1.02416504
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.01476992
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.00956256
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00509640
87ESR1_21235772_ChIP-Seq_MCF-7_Human0.99205924
88ERG_20517297_ChIP-Seq_VCAP_Human0.96786653
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96398146
90FOXP1_21924763_ChIP-Seq_HESCs_Human0.94927468
91TET1_21451524_ChIP-Seq_MESCs_Mouse0.91311103
92RARB_24833708_ChIP-Seq_LIVER_Mouse0.90444708
93RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89790014
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89215919
95PHF8_20622854_ChIP-Seq_HELA_Human0.88709467
96RACK7_27058665_Chip-Seq_MCF-7_Human0.88379095
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87606117
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86867579
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84415445
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81038652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.54965630
2MP0000372_irregular_coat_pigmentation5.50179600
3MP0005171_absent_coat_pigmentation4.48472288
4MP0003136_yellow_coat_color3.76006348
5MP0001346_abnormal_lacrimal_gland3.73065071
6MP0005083_abnormal_biliary_tract3.33993973
7MP0002138_abnormal_hepatobiliary_system3.04082674
8MP0010030_abnormal_orbit_morphology3.00602997
9MP0010094_abnormal_chromosome_stability2.87052648
10MP0003693_abnormal_embryo_hatching2.67811749
11MP0000579_abnormal_nail_morphology2.49339633
12MP0005167_abnormal_blood-brain_barrier2.45984357
13MP0009697_abnormal_copulation2.30113063
14MP0004381_abnormal_hair_follicle2.29416505
15MP0003718_maternal_effect2.14589131
16MP0002396_abnormal_hematopoietic_system2.05365135
17MP0008058_abnormal_DNA_repair2.03740489
18MP0002102_abnormal_ear_morphology1.94043636
19MP0005174_abnormal_tail_pigmentation1.85352414
20MP0001879_abnormal_lymphatic_vessel1.77890717
21MP0003077_abnormal_cell_cycle1.63748434
22MP0003111_abnormal_nucleus_morphology1.55915338
23MP0001986_abnormal_taste_sensitivity1.45757818
24MP0005075_abnormal_melanosome_morpholog1.36260333
25MP0003186_abnormal_redox_activity1.27206591
26MP0003221_abnormal_cardiomyocyte_apopto1.26880122
27MP0005409_darkened_coat_color1.22645768
28MP0001485_abnormal_pinna_reflex1.21532194
29MP0009278_abnormal_bone_marrow1.20913842
30MP0005248_abnormal_Harderian_gland1.18141708
31MP0001324_abnormal_eye_pigmentation1.17770432
32MP0001293_anophthalmia1.16582910
33MP0001764_abnormal_homeostasis1.14757065
34MP0005330_cardiomyopathy1.12368723
35MP0002295_abnormal_pulmonary_circulatio1.05627670
36MP0002019_abnormal_tumor_incidence1.02194972
37MP0005253_abnormal_eye_physiology0.96729378
38MP0004142_abnormal_muscle_tone0.96534217
39MP0006292_abnormal_olfactory_placode0.95994804
40MP0004957_abnormal_blastocyst_morpholog0.95332404
41MP0009764_decreased_sensitivity_to0.92632845
42MP0003984_embryonic_growth_retardation0.90343464
43MP0002088_abnormal_embryonic_growth/wei0.86656394
44MP0008873_increased_physiological_sensi0.86540848
45MP0000749_muscle_degeneration0.84531861
46MP0005076_abnormal_cell_differentiation0.84491720
47MP0002653_abnormal_ependyma_morphology0.84458752
48MP0003959_abnormal_lean_body0.83615569
49MP0003252_abnormal_bile_duct0.83022055
50MP0000566_synostosis0.82427959
51MP0001835_abnormal_antigen_presentation0.81900912
52MP0001529_abnormal_vocalization0.80871927
53MP0004808_abnormal_hematopoietic_stem0.80801377
54MP0000015_abnormal_ear_pigmentation0.77697490
55MP0005397_hematopoietic_system_phenotyp0.77314563
56MP0001545_abnormal_hematopoietic_system0.77314563
57MP0005647_abnormal_sex_gland0.76483800
58MP0005410_abnormal_fertilization0.75172984
59MP0001672_abnormal_embryogenesis/_devel0.73637762
60MP0005380_embryogenesis_phenotype0.73637762
61MP0005391_vision/eye_phenotype0.72882351
62MP0000627_abnormal_mammary_gland0.72535527
63MP0003303_peritoneal_inflammation0.72375110
64MP0003453_abnormal_keratinocyte_physiol0.72107923
65MP0001968_abnormal_touch/_nociception0.71110655
66MP0008961_abnormal_basal_metabolism0.71088760
67MP0000747_muscle_weakness0.70866622
68MP0000313_abnormal_cell_death0.68939157
69MP0003638_abnormal_response/metabolism_0.68456520
70MP0000767_abnormal_smooth_muscle0.67897315
71MP0000350_abnormal_cell_proliferation0.66738598
72MP0006054_spinal_hemorrhage0.65435642
73MP0004510_myositis0.64744455
74MP0005084_abnormal_gallbladder_morpholo0.63737898
75MP0005387_immune_system_phenotype0.63657898
76MP0001790_abnormal_immune_system0.63657898
77MP0000003_abnormal_adipose_tissue0.63209077
78MP0008932_abnormal_embryonic_tissue0.62534900
79MP0001853_heart_inflammation0.61291870
80MP0002736_abnormal_nociception_after0.60744992
81MP0005584_abnormal_enzyme/coenzyme_acti0.59663242
82MP0002148_abnormal_hypersensitivity_rea0.59469964
83MP0003195_calcinosis0.58017429
84MP0005376_homeostasis/metabolism_phenot0.56964269
85MP0005377_hearing/vestibular/ear_phenot0.56771588
86MP0003878_abnormal_ear_physiology0.56771588
87MP0005448_abnormal_energy_balance0.56484083
88MP0005551_abnormal_eye_electrophysiolog0.56399410
89MP0005365_abnormal_bile_salt0.55987835
90MP0005395_other_phenotype0.54873799
91MP0001177_atelectasis0.54778317
92MP0009785_altered_susceptibility_to0.54199548
93MP0001486_abnormal_startle_reflex0.53575518
94MP0005164_abnormal_response_to0.53429122
95MP0003786_premature_aging0.53346899
96MP0004742_abnormal_vestibular_system0.52468173
97MP0003705_abnormal_hypodermis_morpholog0.52005007
98MP0001186_pigmentation_phenotype0.51837951
99MP0002697_abnormal_eye_size0.49743534
100MP0002638_abnormal_pupillary_reflex0.49557557

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)6.00702238
2Abnormality of the labia minora (HP:0012880)5.99594198
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.70942501
4Reticulocytopenia (HP:0001896)5.30991680
5Abnormality of DNA repair (HP:0003254)5.13695338
6Duplicated collecting system (HP:0000081)5.10768615
7Abnormality of the anterior horn cell (HP:0006802)4.93615696
8Degeneration of anterior horn cells (HP:0002398)4.93615696
9Spinal muscular atrophy (HP:0007269)4.30462309
10Abnormal number of erythroid precursors (HP:0012131)4.24460098
11Abnormality of the renal collecting system (HP:0004742)4.22622805
12Reduced antithrombin III activity (HP:0001976)4.13375653
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.94266960
14Hypoplasia of the pons (HP:0012110)3.91122718
15Absent radius (HP:0003974)3.82776450
16Type I transferrin isoform profile (HP:0003642)3.72406771
17Abnormality of cells of the erythroid lineage (HP:0012130)3.72154680
18Aplasia involving forearm bones (HP:0009822)3.53549606
19Absent forearm bone (HP:0003953)3.53549606
20Abnormality of the pons (HP:0007361)3.49401123
21Absent thumb (HP:0009777)3.40464954
22Aplasia/Hypoplasia of the uvula (HP:0010293)3.37422811
23Abnormality of chromosome stability (HP:0003220)3.36579553
24Progressive muscle weakness (HP:0003323)3.32278778
25Parakeratosis (HP:0001036)3.27069336
26Hypothermia (HP:0002045)3.26093789
27Anteriorly placed anus (HP:0001545)3.17655182
28Abnormality of the preputium (HP:0100587)3.08512824
29Ectopic kidney (HP:0000086)3.01338031
30Ureteral duplication (HP:0000073)2.96069133
31Abnormality of pyrimidine metabolism (HP:0004353)2.83739334
32Abnormality of placental membranes (HP:0011409)2.82760387
33Amniotic constriction ring (HP:0009775)2.82760387
34Abnormal pupillary function (HP:0007686)2.82539389
35Birth length less than 3rd percentile (HP:0003561)2.81553607
36Clubbing of toes (HP:0100760)2.79118872
37Meckel diverticulum (HP:0002245)2.72399136
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69170695
39Testicular atrophy (HP:0000029)2.60459272
40Abnormality of the ileum (HP:0001549)2.54299006
41Microvesicular hepatic steatosis (HP:0001414)2.52463980
42Poikiloderma (HP:0001029)2.51839727
43Squamous cell carcinoma (HP:0002860)2.50116905
44Limb hypertonia (HP:0002509)2.48779103
45Aqueductal stenosis (HP:0002410)2.41021059
46Small hand (HP:0200055)2.37069615
47Horseshoe kidney (HP:0000085)2.36911263
48Pustule (HP:0200039)2.34615962
49Abnormality of the carotid arteries (HP:0005344)2.33501479
50Flat occiput (HP:0005469)2.32947361
51Entropion (HP:0000621)2.31769843
52Overriding aorta (HP:0002623)2.26185869
53High anterior hairline (HP:0009890)2.26094473
54Abnormal protein glycosylation (HP:0012346)2.23267532
55Abnormal glycosylation (HP:0012345)2.23267532
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23267532
57Abnormal protein N-linked glycosylation (HP:0012347)2.23267532
58Adactyly (HP:0009776)2.20573290
59Prolonged partial thromboplastin time (HP:0003645)2.19116135
60Abnormality of the labia (HP:0000058)2.18441913
61Duplication of thumb phalanx (HP:0009942)2.15133471
62IgM deficiency (HP:0002850)2.14014439
63Pallor (HP:0000980)2.13067753
64Duodenal stenosis (HP:0100867)2.08513921
65Small intestinal stenosis (HP:0012848)2.08513921
66Nasal polyposis (HP:0100582)2.03404212
67Stenosis of the external auditory canal (HP:0000402)2.01018290
68Short humerus (HP:0005792)1.95509841
69Aplasia/Hypoplasia of the patella (HP:0006498)1.91898924
70Aplasia cutis congenita (HP:0001057)1.90142580
71Lower limb hyperreflexia (HP:0002395)1.86643815
72Progressive microcephaly (HP:0000253)1.86596556
73Patellar aplasia (HP:0006443)1.86151786
74Hypoplastic female external genitalia (HP:0012815)1.84554156
75Esophageal atresia (HP:0002032)1.84530392
76Facial hemangioma (HP:0000329)1.83923694
77Cortical dysplasia (HP:0002539)1.81505969
78Abnormality of the duodenum (HP:0002246)1.79221994
79Macrocytic anemia (HP:0001972)1.77609517
80Limited elbow extension (HP:0001377)1.76127316
81Renal agenesis (HP:0000104)1.75848059
82Rib fusion (HP:0000902)1.75784645
83Dyschromatopsia (HP:0007641)1.75735211
84Short thumb (HP:0009778)1.75514170
85Severe global developmental delay (HP:0011344)1.74013568
86Abnormality of the labia majora (HP:0012881)1.73866404
87Triphalangeal thumb (HP:0001199)1.73025711
88Attenuation of retinal blood vessels (HP:0007843)1.72281050
89Labial hypoplasia (HP:0000066)1.71730525
90Nuclear cataract (HP:0100018)1.70664584
91Basal cell carcinoma (HP:0002671)1.69661411
92Lipid accumulation in hepatocytes (HP:0006561)1.68540977
93Abnormal hair whorl (HP:0010721)1.67684172
94Anal stenosis (HP:0002025)1.67592708
95IgA deficiency (HP:0002720)1.66469992
96Pulmonary artery stenosis (HP:0004415)1.65465170
97Abnormality of reticulocytes (HP:0004312)1.64830496
98Mitochondrial inheritance (HP:0001427)1.62476223
99Limb dystonia (HP:0002451)1.62467317
100Aplasia/hypoplasia of the humerus (HP:0006507)1.62357071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DAPK24.30403381
2VRK23.81857151
3VRK13.64461176
4TLK13.61379612
5MAPK152.99414520
6CCNB12.87309390
7NME12.87119640
8ZAK2.82587035
9FGFR22.65069516
10BUB12.39888631
11PASK2.30666804
12MAP3K62.09024180
13CAMK1G2.08479257
14TSSK62.07864494
15EIF2AK12.00487937
16PLK21.92981256
17CAMK1D1.79849890
18PLK31.78463875
19CDK121.67093078
20NME21.49948182
21BRSK11.46535169
22BMPR1B1.39621370
23PDK21.37245397
24SIK11.30107800
25PIM21.28742993
26BCKDK1.27436716
27BLK1.25738677
28MKNK11.19038040
29RPS6KA51.11188138
30IKBKE1.08235114
31MUSK1.07665450
32MAP2K61.04553545
33WNK40.97484852
34RIPK10.96364397
35ATR0.89956911
36TYRO30.89873408
37ERN10.88770840
38CDC70.87451042
39IRAK20.86350291
40PTK2B0.82370389
41TTK0.81856956
42MARK20.81092863
43EIF2AK30.80536382
44BRSK20.80381771
45IKBKB0.79438390
46NEK90.78873112
47SRPK10.77625214
48DMPK0.75842933
49CHUK0.73042665
50TYK20.72974347
51RPS6KL10.71716875
52RPS6KC10.71716875
53RPS6KA60.71274464
54AURKB0.71009149
55PRKCI0.71005876
56PKN20.70823186
57MST1R0.70530386
58PAK30.69443091
59ADRBK20.68925372
60CHEK20.68358627
61EPHA20.61803826
62TGFBR10.61741935
63STK240.60948115
64MST40.57894076
65ADRBK10.57548007
66RPS6KA10.55509807
67IRAK10.55243626
68BTK0.54299394
69AURKA0.52869859
70PRKCH0.52013738
71OXSR10.51053544
72DYRK20.45933618
73MAPK70.45892659
74FLT30.45805247
75PKN10.45632488
76EIF2AK20.44283559
77PLK40.43704668
78RPS6KA20.43538962
79FGFR10.43513657
80GRK10.43472272
81PAK40.43228389
82MAP2K70.41419759
83ATM0.39986096
84MAP4K10.39406611
85INSRR0.39150396
86ICK0.34967289
87PRKCQ0.34277490
88PLK10.33996170
89KIT0.32894843
90ROCK20.32482524
91ROCK10.32356509
92CSNK2A20.31640142
93MAP3K50.31032463
94TBK10.30745683
95PNCK0.30708958
96TAOK20.30661384
97CSNK2A10.30101566
98CHEK10.29899264
99MAPK130.29771437
100ERBB20.29372951

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.94191057
2DNA replication_Homo sapiens_hsa030303.77475703
3Ribosome_Homo sapiens_hsa030103.65888747
4RNA polymerase_Homo sapiens_hsa030203.40037399
5Oxidative phosphorylation_Homo sapiens_hsa001903.26149033
6Non-homologous end-joining_Homo sapiens_hsa034503.19020673
7Homologous recombination_Homo sapiens_hsa034402.97868131
8Fanconi anemia pathway_Homo sapiens_hsa034602.92850337
9Parkinsons disease_Homo sapiens_hsa050122.58251182
10Base excision repair_Homo sapiens_hsa034102.27912068
11Mismatch repair_Homo sapiens_hsa034302.19209041
12Nucleotide excision repair_Homo sapiens_hsa034202.12019790
13Alzheimers disease_Homo sapiens_hsa050102.10413159
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98854812
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.92106520
16Pyrimidine metabolism_Homo sapiens_hsa002401.86703462
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84995403
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83366495
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82508091
20Huntingtons disease_Homo sapiens_hsa050161.76739878
21Pyruvate metabolism_Homo sapiens_hsa006201.75899154
22Systemic lupus erythematosus_Homo sapiens_hsa053221.75798635
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68707625
24p53 signaling pathway_Homo sapiens_hsa041151.66787248
25Phenylalanine metabolism_Homo sapiens_hsa003601.64557362
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61965730
27Purine metabolism_Homo sapiens_hsa002301.38737503
28Alcoholism_Homo sapiens_hsa050341.36813388
29N-Glycan biosynthesis_Homo sapiens_hsa005101.32207138
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25509688
31RNA degradation_Homo sapiens_hsa030181.21028536
32Other glycan degradation_Homo sapiens_hsa005111.14051477
33Glutathione metabolism_Homo sapiens_hsa004801.11599022
34Phototransduction_Homo sapiens_hsa047441.11048912
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.07249351
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03088721
37RNA transport_Homo sapiens_hsa030131.02332302
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00721530
39ABC transporters_Homo sapiens_hsa020100.97093115
40Histidine metabolism_Homo sapiens_hsa003400.94897316
41Cell cycle_Homo sapiens_hsa041100.94842555
42Fructose and mannose metabolism_Homo sapiens_hsa000510.94147422
43Steroid biosynthesis_Homo sapiens_hsa001000.91935134
44Sulfur relay system_Homo sapiens_hsa041220.89224406
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88490348
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85602941
47Spliceosome_Homo sapiens_hsa030400.85044836
48Legionellosis_Homo sapiens_hsa051340.83544590
49Basal cell carcinoma_Homo sapiens_hsa052170.82078195
50Epstein-Barr virus infection_Homo sapiens_hsa051690.81200445
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.79359086
52Tryptophan metabolism_Homo sapiens_hsa003800.75115523
53Notch signaling pathway_Homo sapiens_hsa043300.71349759
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70785336
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70188199
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69365809
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64028048
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62935623
59Tyrosine metabolism_Homo sapiens_hsa003500.61957020
60Fatty acid biosynthesis_Homo sapiens_hsa000610.61502068
61Protein export_Homo sapiens_hsa030600.57861413
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57125319
63Ovarian steroidogenesis_Homo sapiens_hsa049130.56038420
64Cardiac muscle contraction_Homo sapiens_hsa042600.54494270
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.52633164
66Metabolic pathways_Homo sapiens_hsa011000.50024770
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.46463012
68Biosynthesis of amino acids_Homo sapiens_hsa012300.45982851
69Viral carcinogenesis_Homo sapiens_hsa052030.45383449
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43753265
71Basal transcription factors_Homo sapiens_hsa030220.41215801
72Cocaine addiction_Homo sapiens_hsa050300.37512283
73TGF-beta signaling pathway_Homo sapiens_hsa043500.37253733
74Mineral absorption_Homo sapiens_hsa049780.34570819
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32980252
76Carbon metabolism_Homo sapiens_hsa012000.31892311
77Chemical carcinogenesis_Homo sapiens_hsa052040.27275549
78Arginine biosynthesis_Homo sapiens_hsa002200.25533425
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24879350
80Primary immunodeficiency_Homo sapiens_hsa053400.22733357
81Bile secretion_Homo sapiens_hsa049760.21834047
82Regulation of autophagy_Homo sapiens_hsa041400.21693422
83Gap junction_Homo sapiens_hsa045400.19979002
84Propanoate metabolism_Homo sapiens_hsa006400.19673948
85Hippo signaling pathway_Homo sapiens_hsa043900.17615641
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17337952
87Vibrio cholerae infection_Homo sapiens_hsa051100.16054711
88Lysine degradation_Homo sapiens_hsa003100.14817827
89Taste transduction_Homo sapiens_hsa047420.13615987
90HTLV-I infection_Homo sapiens_hsa051660.12978366
91One carbon pool by folate_Homo sapiens_hsa006700.12788479
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10569372
93Prostate cancer_Homo sapiens_hsa052150.10073984
94Vitamin digestion and absorption_Homo sapiens_hsa049770.10032395
95Arginine and proline metabolism_Homo sapiens_hsa003300.09736831
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.08781324
97Fatty acid metabolism_Homo sapiens_hsa012120.08744450
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08644002
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08311354
100Fatty acid degradation_Homo sapiens_hsa000710.08277384

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