TUBGCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)7.10660512
2DNA strand elongation involved in DNA replication (GO:0006271)5.58744057
3DNA strand elongation (GO:0022616)5.47296513
4negative regulation of erythrocyte differentiation (GO:0045647)5.40090163
5protein localization to kinetochore (GO:0034501)5.33272398
6DNA replication initiation (GO:0006270)5.23848681
7mannose metabolic process (GO:0006013)5.16319563
8telomere maintenance via semi-conservative replication (GO:0032201)4.89054941
9DNA replication checkpoint (GO:0000076)4.73813119
10sister chromatid segregation (GO:0000819)4.51707308
11mitotic recombination (GO:0006312)4.50942305
12telomere maintenance via recombination (GO:0000722)4.43356442
13mitotic sister chromatid segregation (GO:0000070)4.37714094
14protein localization to chromosome, centromeric region (GO:0071459)4.36705093
15nucleobase biosynthetic process (GO:0046112)4.34759907
16telomere maintenance via telomere lengthening (GO:0010833)4.29345342
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.24656444
18DNA duplex unwinding (GO:0032508)4.11069165
19DNA geometric change (GO:0032392)4.10398999
20IMP biosynthetic process (GO:0006188)4.07194611
21DNA replication-dependent nucleosome assembly (GO:0006335)4.05126044
22DNA replication-dependent nucleosome organization (GO:0034723)4.05126044
23mitotic nuclear envelope disassembly (GO:0007077)3.93842167
24mitotic chromosome condensation (GO:0007076)3.92917100
25mitotic metaphase plate congression (GO:0007080)3.92540128
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.92069818
27folic acid-containing compound biosynthetic process (GO:0009396)3.86941134
28postreplication repair (GO:0006301)3.86354649
29purine nucleobase biosynthetic process (GO:0009113)3.84063885
30translesion synthesis (GO:0019985)3.80443344
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.80033314
32response to peptidoglycan (GO:0032494)3.79782295
33nuclear pore organization (GO:0006999)3.78295263
34protein localization to endosome (GO:0036010)3.77249018
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.76406539
36barbed-end actin filament capping (GO:0051016)3.72371375
37NIK/NF-kappaB signaling (GO:0038061)3.72038699
38nuclear envelope disassembly (GO:0051081)3.70166810
39membrane disassembly (GO:0030397)3.70166810
40mitotic sister chromatid cohesion (GO:0007064)3.61000419
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.60578003
42COPI coating of Golgi vesicle (GO:0048205)3.59198451
43Golgi transport vesicle coating (GO:0048200)3.59198451
44DNA conformation change (GO:0071103)3.52099214
45chromosome condensation (GO:0030261)3.52026956
46amyloid precursor protein catabolic process (GO:0042987)3.50312657
47metaphase plate congression (GO:0051310)3.49292493
48nuclear pore complex assembly (GO:0051292)3.49194707
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47407655
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.47407655
51modulation by symbiont of host immune response (GO:0052553)3.47407655
52positive regulation by symbiont of host defense response (GO:0052509)3.47407655
53modulation by symbiont of host defense response (GO:0052031)3.47407655
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47407655
55regulation of nuclear cell cycle DNA replication (GO:0033262)3.46312526
56histone H2A acetylation (GO:0043968)3.45836396
57DNA topological change (GO:0006265)3.44816965
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.44662032
59regulation of centriole replication (GO:0046599)3.43535332
60ribosomal small subunit biogenesis (GO:0042274)3.43376053
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.41099111
62attachment of spindle microtubules to kinetochore (GO:0008608)3.40846844
63chromatin remodeling at centromere (GO:0031055)3.39349925
64axonemal dynein complex assembly (GO:0070286)3.36672992
65formation of translation preinitiation complex (GO:0001731)3.36667465
66regulation of centrosome cycle (GO:0046605)3.35375320
67negative regulation of chromosome segregation (GO:0051985)3.35114538
68CENP-A containing nucleosome assembly (GO:0034080)3.34238836
69regulation of chromosome segregation (GO:0051983)3.33462394
70negative regulation of RNA splicing (GO:0033119)3.32619154
71apoptotic process involved in morphogenesis (GO:0060561)3.31137749
72IMP metabolic process (GO:0046040)3.31050129
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.30744534
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30744534
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30744534
76negative regulation of sister chromatid segregation (GO:0033046)3.30744534
77UV protection (GO:0009650)3.30507615
78DNA replication-independent nucleosome organization (GO:0034724)3.30335765
79DNA replication-independent nucleosome assembly (GO:0006336)3.30335765
80protein localization to chromosome (GO:0034502)3.29933422
81positive regulation of Cdc42 GTPase activity (GO:0043089)3.29183346
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27950101
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.27733639
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27733639
85mismatch repair (GO:0006298)3.26138323
86spliceosomal tri-snRNP complex assembly (GO:0000244)3.25442568
87modulation by virus of host process (GO:0019054)3.24657163
88regulation of spindle organization (GO:0090224)3.24014305
89negative regulation of cell size (GO:0045792)3.23836055
90telomere maintenance (GO:0000723)3.23628687
91telomere organization (GO:0032200)3.23502312
92establishment of chromosome localization (GO:0051303)3.23017726
93positive regulation of chromosome segregation (GO:0051984)3.21180584
94intra-S DNA damage checkpoint (GO:0031573)3.20247622
95regulation of DNA damage checkpoint (GO:2000001)3.19643998
96spindle assembly checkpoint (GO:0071173)3.18708380
97mitotic spindle assembly checkpoint (GO:0007094)3.18613577
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18541946
99hypotonic response (GO:0006971)3.18512594
100regulation of histone H3-K9 methylation (GO:0051570)3.17807540
101regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16153076
102kinetochore organization (GO:0051383)3.15501677
103modulation by symbiont of host cellular process (GO:0044068)3.15330602
104deoxyribonucleotide biosynthetic process (GO:0009263)3.14650541
105regulation of double-strand break repair via homologous recombination (GO:0010569)3.14479577
106regulation of leukocyte degranulation (GO:0043300)3.14240126
107regulation of apoptotic process involved in morphogenesis (GO:1902337)3.13970299
108pentose-phosphate shunt (GO:0006098)3.11510507
109base-excision repair (GO:0006284)3.11255927
110DNA packaging (GO:0006323)3.10890901
111histone exchange (GO:0043486)3.10520317
112regulation of mammary gland epithelial cell proliferation (GO:0033599)3.10473246
113positive regulation of histone deacetylation (GO:0031065)3.10459451
114negative regulation of mRNA processing (GO:0050686)3.09889946
115dosage compensation (GO:0007549)3.09584973
116regulation of sister chromatid cohesion (GO:0007063)3.09367553
117dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.08368641
118ribosomal small subunit assembly (GO:0000028)3.07455666
119tooth mineralization (GO:0034505)3.07132793
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07055429
121viral mRNA export from host cell nucleus (GO:0046784)3.06955253
122pinocytosis (GO:0006907)3.03585924
123regulation of mitotic sister chromatid separation (GO:0010965)3.02620525
124regulation of mitotic sister chromatid segregation (GO:0033047)3.02620525
125regulation of sister chromatid segregation (GO:0033045)3.02620525
126chromosome segregation (GO:0007059)3.01964475
127negative regulation of histone methylation (GO:0031061)3.01158925
128glucose catabolic process (GO:0006007)3.01048201
129* mitotic cell cycle (GO:0000278)2.97864995
130mRNA splicing, via spliceosome (GO:0000398)2.96252073
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96252073
132regulation of early endosome to late endosome transport (GO:2000641)2.95842335
133spliceosomal snRNP assembly (GO:0000387)2.95073177
134chromatin assembly or disassembly (GO:0006333)2.94394655
135spindle checkpoint (GO:0031577)2.93825827
136mitotic spindle checkpoint (GO:0071174)2.93358222
137amino sugar catabolic process (GO:0046348)2.85234295
138activation of Rac GTPase activity (GO:0032863)2.82788088
139protein insertion into membrane (GO:0051205)2.81986096
140regulation of necrotic cell death (GO:0010939)2.81804109
141motile cilium assembly (GO:0044458)2.81330445
142amyloid precursor protein metabolic process (GO:0042982)2.80710002
143regulation of chromatin binding (GO:0035561)2.80636642
144regulation of mast cell degranulation (GO:0043304)2.79738493
145response to muramyl dipeptide (GO:0032495)2.79234611
146regulation of defense response to virus by virus (GO:0050690)2.79199146
147cellular response to thyroid hormone stimulus (GO:0097067)2.78556693
148retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77715150
149cellular response to virus (GO:0098586)2.77333999
150regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75790161
151regulation of receptor binding (GO:1900120)2.75583446
152tolerance induction (GO:0002507)2.74963608
153N-acetylneuraminate metabolic process (GO:0006054)2.71289568
154regulation of monocyte differentiation (GO:0045655)2.71189426
155viral protein processing (GO:0019082)2.70085338
156positive regulation of leukocyte degranulation (GO:0043302)2.68739671
157negative regulation of necroptotic process (GO:0060546)2.66090512
158negative regulation of granulocyte differentiation (GO:0030853)2.65555476
159activation of MAPKKK activity (GO:0000185)2.63995717
160semaphorin-plexin signaling pathway (GO:0071526)2.63745889
161planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63417061
162peptidyl-arginine omega-N-methylation (GO:0035247)2.63116647
163endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.62381263
164virion assembly (GO:0019068)2.62228008
165regulation of superoxide anion generation (GO:0032928)2.62183491
166protein maturation by protein folding (GO:0022417)2.61140041
167cell-cell junction maintenance (GO:0045217)2.60705078
168stress fiber assembly (GO:0043149)2.59210623
169positive regulation of protein deacetylation (GO:0090312)2.58853079
170intracellular estrogen receptor signaling pathway (GO:0030520)2.56845865
171apoptotic cell clearance (GO:0043277)2.55098788
172negative regulation of fatty acid transport (GO:2000192)2.53205178
173regulation of cholesterol storage (GO:0010885)2.52688231
174proline biosynthetic process (GO:0006561)2.51401797
175response to xenobiotic stimulus (GO:0009410)2.49801845
176retrograde transport, endosome to Golgi (GO:0042147)2.49309972
177regulation of necroptotic process (GO:0060544)2.49275334
178endothelial cell chemotaxis (GO:0035767)2.48479914
179negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42997378
180regulation of regulated secretory pathway (GO:1903305)2.41229106
181GDP-mannose metabolic process (GO:0019673)2.41107673
182cellular response to arsenic-containing substance (GO:0071243)2.39539317
183negative regulation of viral release from host cell (GO:1902187)2.38620260
184response to progesterone (GO:0032570)2.38252008
185negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37192774
186protein retention in ER lumen (GO:0006621)2.37185524
187membrane protein intracellular domain proteolysis (GO:0031293)2.36696137
188response to thyroid hormone (GO:0097066)2.36523143
189regulation of fatty acid beta-oxidation (GO:0031998)2.36511142
190NADPH regeneration (GO:0006740)2.34818906
191lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33558259
192pyrimidine-containing compound salvage (GO:0008655)2.33556041
193pyrimidine nucleoside salvage (GO:0043097)2.33556041
194modulation by virus of host morphology or physiology (GO:0019048)2.33553805
195regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31675463
196negative regulation of toll-like receptor signaling pathway (GO:0034122)2.30925639
197negative regulation of DNA-templated transcription, elongation (GO:0032785)2.30580311
198mature B cell differentiation involved in immune response (GO:0002313)2.29974532
199germinal center formation (GO:0002467)2.29240338
200regulation of mast cell activation involved in immune response (GO:0033006)2.28795209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.07310561
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21134058
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.86386341
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.77022587
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70433516
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29171202
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.13831586
8LXR_22292898_ChIP-Seq_THP-1_Human2.76772474
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63763449
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.55498570
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53785767
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52964095
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48573272
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.45862604
15AR_21909140_ChIP-Seq_LNCAP_Human2.43954952
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41427609
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35266495
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.33206707
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32824989
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.29696525
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23732045
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.22117792
23XRN2_22483619_ChIP-Seq_HELA_Human2.22081668
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20898971
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20838079
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18772967
27* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17781918
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16418933
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16322102
30RACK7_27058665_Chip-Seq_MCF-7_Human2.13939440
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12904168
32ZNF263_19887448_ChIP-Seq_K562_Human2.10008511
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09694897
34TP63_17297297_ChIP-ChIP_HaCaT_Human2.06171556
35E2F7_22180533_ChIP-Seq_HELA_Human11.7103519
36CIITA_25753668_ChIP-Seq_RAJI_Human1.96389259
37MYC_22102868_ChIP-Seq_BL_Human1.96073643
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96043411
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90934172
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90599238
41P68_20966046_ChIP-Seq_HELA_Human1.88346596
42KDM2B_26808549_Chip-Seq_DND41_Human1.88336528
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88307451
44TCF7_22412390_ChIP-Seq_EML_Mouse1.85992717
45VDR_24763502_ChIP-Seq_THP-1_Human1.84585649
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.83051976
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.80901153
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75699165
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75482145
50FOXP3_21729870_ChIP-Seq_TREG_Human1.75401108
51VDR_23849224_ChIP-Seq_CD4+_Human1.73616874
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71387939
53* GABP_19822575_ChIP-Seq_HepG2_Human1.70096323
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69465929
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67656838
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.64235476
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64159629
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63404763
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.63279005
60DCP1A_22483619_ChIP-Seq_HELA_Human1.62458889
61TTF2_22483619_ChIP-Seq_HELA_Human1.61904169
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60002307
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59758139
64KDM2B_26808549_Chip-Seq_K562_Human1.58697924
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58588034
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57175433
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55641121
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53502786
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53109555
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51283062
71SMC4_20622854_ChIP-Seq_HELA_Human1.50794445
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49202296
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48276279
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47427986
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46222094
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45027088
77KDM5A_27292631_Chip-Seq_BREAST_Human1.44942528
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44679817
79BCOR_27268052_Chip-Seq_Bcells_Human1.44355170
80MAF_26560356_Chip-Seq_TH1_Human1.43879877
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.43438748
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42572651
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41181389
84BCL6_27268052_Chip-Seq_Bcells_Human1.39878746
85MAF_26560356_Chip-Seq_TH2_Human1.38940589
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.35586628
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.34174753
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33846045
89TP53_22127205_ChIP-Seq_IMR90_Human1.33296206
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33128756
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33091232
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.32749624
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32050720
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32013472
95* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31365198
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30652053
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29409215
98* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29198352
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28804867
100* CREB1_26743006_Chip-Seq_LNCaP_Human1.28765465
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28401183
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27926165
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26683300
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26378156
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25299193
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24362042
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24209179
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23992217
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23953428
110VDR_21846776_ChIP-Seq_THP-1_Human1.22935430
111UTX_26944678_Chip-Seq_JUKART_Human1.22181214
112PHF8_20622854_ChIP-Seq_HELA_Human1.21250196
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.20468381
114* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20110673
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.19437816
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17893435
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17683696
118ERG_21242973_ChIP-ChIP_JURKAT_Human1.15913760
119* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14543056
120NCOR1_26117541_ChIP-Seq_K562_Human1.14492210
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13809763
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13020177
123* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12762672
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12522927
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11835685
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.11786558
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11375588
128* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11351804
129MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11048701
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10717689
131ATF3_27146783_Chip-Seq_COLON_Human1.10504084
132YY1_22570637_ChIP-Seq_MALME-3M_Human1.09968725
133* TP63_22573176_ChIP-Seq_HFKS_Human1.09152165
134DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09134324
135PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08862265
136CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07499490
137RUNX1_27514584_Chip-Seq_MCF-7_Human1.07009335
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06248376
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05723409
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05563603
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05247089
142CTCF_27219007_Chip-Seq_Bcells_Human1.05098119
143ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04963683
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04615394
145E2F1_20622854_ChIP-Seq_HELA_Human1.03670948
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03290748
147ELK1_19687146_ChIP-ChIP_HELA_Human1.02825362
148NANOG_21062744_ChIP-ChIP_HESCs_Human1.02243906
149TFEB_21752829_ChIP-Seq_HELA_Human1.01971660
150NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01411743
151* SPI1_23127762_ChIP-Seq_K562_Human1.01280172
152GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01241345
153CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01225106
154RARA_24833708_ChIP-Seq_LIVER_Mouse1.01188276
155SA1_27219007_Chip-Seq_Bcells_Human1.01152484
156SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00440656
157CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99711993
158ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98256862
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94269734
160PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91537114
161SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91149970
162SRF_21415370_ChIP-Seq_HL-1_Mouse0.89445872
163FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87156697
164POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86953286
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86252364
166SALL1_21062744_ChIP-ChIP_HESCs_Human0.85476104
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84029905
168FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81449248
169DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80998249
170STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80770736
171HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79589121
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77113786
173CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76858343
174MYC_18940864_ChIP-ChIP_HL60_Human0.75931100
175PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75778876
176* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72443549
177* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68805253
178TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65445628
179NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.65157520
180ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.65122998
181SOX2_16153702_ChIP-ChIP_HESCs_Human0.64667492
182SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.61753245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.39782898
2MP0003111_abnormal_nucleus_morphology4.82463011
3MP0005058_abnormal_lysosome_morphology4.52072101
4MP0003693_abnormal_embryo_hatching4.03827115
5MP0003077_abnormal_cell_cycle3.94419507
6MP0004957_abnormal_blastocyst_morpholog3.80121979
7MP0009840_abnormal_foam_cell3.73937938
8MP0005451_abnormal_body_composition3.68769835
9MP0008057_abnormal_DNA_replication3.39817478
10MP0003123_paternal_imprinting3.26370087
11MP0008877_abnormal_DNA_methylation3.20017105
12MP0003172_abnormal_lysosome_physiology3.03888309
13MP0008058_abnormal_DNA_repair3.03354969
14MP0008007_abnormal_cellular_replicative2.75716527
15MP0003436_decreased_susceptibility_to2.70846424
16MP0008932_abnormal_embryonic_tissue2.67653595
17MP0003191_abnormal_cellular_cholesterol2.61615593
18MP0004233_abnormal_muscle_weight2.47325144
19MP0001730_embryonic_growth_arrest2.41224552
20MP0008260_abnormal_autophagy2.32917187
21MP0003121_genomic_imprinting2.25084442
22MP0003806_abnormal_nucleotide_metabolis2.24010168
23MP0000350_abnormal_cell_proliferation2.19432492
24MP0003303_peritoneal_inflammation2.18459773
25MP0003183_abnormal_peptide_metabolism2.01741144
26MP0004808_abnormal_hematopoietic_stem1.91804365
27MP0002396_abnormal_hematopoietic_system1.90909810
28MP0002877_abnormal_melanocyte_morpholog1.89305777
29MP0000678_abnormal_parathyroid_gland1.88818722
30MP0010352_gastrointestinal_tract_polyps1.82919932
31MP0000537_abnormal_urethra_morphology1.81164519
32MP0004858_abnormal_nervous_system1.78953820
33MP0004510_myositis1.78521729
34MP0001697_abnormal_embryo_size1.73716596
35MP0005257_abnormal_intraocular_pressure1.73419319
36MP0003453_abnormal_keratinocyte_physiol1.70308201
37MP0002080_prenatal_lethality1.69932443
38MP0003329_amyloid_beta_deposits1.69341990
39MP0000604_amyloidosis1.69246160
40MP0004947_skin_inflammation1.66715790
41MP0009333_abnormal_splenocyte_physiolog1.66556641
42MP0001672_abnormal_embryogenesis/_devel1.65397231
43MP0005380_embryogenesis_phenotype1.65397231
44MP0010307_abnormal_tumor_latency1.65027566
45MP0002085_abnormal_embryonic_tissue1.63454431
46MP0000858_altered_metastatic_potential1.62280529
47MP0009384_cardiac_valve_regurgitation1.60524831
48MP0005076_abnormal_cell_differentiation1.59911991
49MP0002419_abnormal_innate_immunity1.59537429
50MP0002084_abnormal_developmental_patter1.58209164
51MP0002249_abnormal_larynx_morphology1.56865101
52MP0006054_spinal_hemorrhage1.55386491
53MP0002653_abnormal_ependyma_morphology1.55119240
54MP0004197_abnormal_fetal_growth/weight/1.49342624
55MP0002210_abnormal_sex_determination1.48848256
56MP0003984_embryonic_growth_retardation1.46355016
57MP0002088_abnormal_embryonic_growth/wei1.44140626
58MP0003787_abnormal_imprinting1.42628525
59MP0000685_abnormal_immune_system1.42063584
60MP0001929_abnormal_gametogenesis1.41546774
61MP0004185_abnormal_adipocyte_glucose1.41127480
62MP0000313_abnormal_cell_death1.40624978
63MP0003300_gastrointestinal_ulcer1.40283281
64MP0000569_abnormal_digit_pigmentation1.39591294
65MP0003075_altered_response_to1.38654492
66MP0000490_abnormal_crypts_of1.36152242
67MP0003786_premature_aging1.35862066
68MP0005025_abnormal_response_to1.35678728
69MP0003566_abnormal_cell_adhesion1.35031470
70MP0005083_abnormal_biliary_tract1.30371068
71MP0000343_altered_response_to1.30015005
72MP0001145_abnormal_male_reproductive1.29848023
73MP0003279_aneurysm1.29074541
74MP0001533_abnormal_skeleton_physiology1.27222321
75MP0002998_abnormal_bone_remodeling1.26873076
76MP0003705_abnormal_hypodermis_morpholog1.26764442
77MP0002086_abnormal_extraembryonic_tissu1.26107293
78MP0010030_abnormal_orbit_morphology1.25454592
79MP0002019_abnormal_tumor_incidence1.25421923
80MP0005387_immune_system_phenotype1.25200187
81MP0001790_abnormal_immune_system1.25200187
82MP0005464_abnormal_platelet_physiology1.24187560
83MP0000733_abnormal_muscle_development1.17919459
84MP0000703_abnormal_thymus_morphology1.17224637
85MP0003698_abnormal_male_reproductive1.17014940
86MP0000750_abnormal_muscle_regeneration1.15025782
87MP0002148_abnormal_hypersensitivity_rea1.11274144
88MP0005409_darkened_coat_color1.11068162
89MP0001853_heart_inflammation1.10436489
90MP0001873_stomach_inflammation1.10279520
91MP0000653_abnormal_sex_gland1.10268281
92MP0001849_ear_inflammation1.09242774
93MP0003119_abnormal_digestive_system1.07526557
94MP0003567_abnormal_fetal_cardiomyocyte1.06607679
95MP0001958_emphysema1.06291736
96MP0003122_maternal_imprinting1.06173674
97MP0002452_abnormal_antigen_presenting1.06120559
98MP0000747_muscle_weakness1.05740658
99MP0003091_abnormal_cell_migration1.05646052
100MP0009672_abnormal_birth_weight1.03040192
101MP0003828_pulmonary_edema1.02378160
102MP0005390_skeleton_phenotype1.00758088
103MP0003315_abnormal_perineum_morphology0.98988332
104MP0003861_abnormal_nervous_system0.98898527
105MP0003890_abnormal_embryonic-extraembry0.98564090
106MP0004133_heterotaxia0.97536435
107MP0001835_abnormal_antigen_presentation0.97351054
108MP0002420_abnormal_adaptive_immunity0.97328164
109MP0000049_abnormal_middle_ear0.97005315
110MP0001819_abnormal_immune_cell0.96921008
111MP0005000_abnormal_immune_tolerance0.96379147
112MP0000003_abnormal_adipose_tissue0.96038872
113MP0002723_abnormal_immune_serum0.95900870
114MP0006292_abnormal_olfactory_placode0.95200095
115MP0002277_abnormal_respiratory_mucosa0.94798764
116MP0005410_abnormal_fertilization0.94783021
117MP0002405_respiratory_system_inflammati0.93129205
118MP0001663_abnormal_digestive_system0.93115290
119MP0003656_abnormal_erythrocyte_physiolo0.92949662
120MP0000767_abnormal_smooth_muscle0.92944566
121MP0001293_anophthalmia0.92420860
122MP0002132_abnormal_respiratory_system0.90494290
123MP0000358_abnormal_cell_content/0.89858499
124MP0005023_abnormal_wound_healing0.88859338
125MP0002160_abnormal_reproductive_system0.88642934
126MP0005501_abnormal_skin_physiology0.88237867
127MP0002796_impaired_skin_barrier0.87264328
128MP0002161_abnormal_fertility/fecundity0.86683967
129MP0008438_abnormal_cutaneous_collagen0.86506209
130MP0002896_abnormal_bone_mineralization0.86361364
131MP0000681_abnormal_thyroid_gland0.85820738
132MP0005384_cellular_phenotype0.85258727
133MP0001542_abnormal_bone_strength0.82351653
134MP0000751_myopathy0.82291606
135MP0002398_abnormal_bone_marrow0.81060014
136MP0009703_decreased_birth_body0.80704694
137MP0001915_intracranial_hemorrhage0.80670951
138MP0005375_adipose_tissue_phenotype0.80229348
139MP0002234_abnormal_pharynx_morphology0.80113561
140MP0010155_abnormal_intestine_physiology0.79061642
141MP0002332_abnormal_exercise_endurance0.77733765
142MP0005165_increased_susceptibility_to0.77179001
143MP0001800_abnormal_humoral_immune0.77055330
144MP0001216_abnormal_epidermal_layer0.77031174
145MP0005623_abnormal_meninges_morphology0.76724163
146MP0005621_abnormal_cell_physiology0.76346113
147MP0005381_digestive/alimentary_phenotyp0.76269677
148MP0000759_abnormal_skeletal_muscle0.75838145
149MP0002098_abnormal_vibrissa_morphology0.75795553
150MP0005187_abnormal_penis_morphology0.75205315
151MP0000428_abnormal_craniofacial_morphol0.74820394
152MP0008469_abnormal_protein_level0.74744637
153MP0008770_decreased_survivor_rate0.74369655
154MP0006082_CNS_inflammation0.73769266
155MP0002060_abnormal_skin_morphology0.73438749
156MP0001545_abnormal_hematopoietic_system0.72977323
157MP0005397_hematopoietic_system_phenotyp0.72977323
158MP0003795_abnormal_bone_structure0.72806205
159MP0000716_abnormal_immune_system0.72023705
160MP0003935_abnormal_craniofacial_develop0.71783847
161MP0001845_abnormal_inflammatory_respons0.71056312
162MP0002751_abnormal_autonomic_nervous0.70533689
163MP0002722_abnormal_immune_system0.70261020
164MP0000467_abnormal_esophagus_morphology0.70173534
165MP0002111_abnormal_tail_morphology0.69497936
166MP0003763_abnormal_thymus_physiology0.67485077
167MP0002269_muscular_atrophy0.66332707
168MP0009278_abnormal_bone_marrow0.65285658
169MP0002114_abnormal_axial_skeleton0.65123233
170MP0001119_abnormal_female_reproductive0.63964443
171MP0002081_perinatal_lethality0.60943005
172MP0002075_abnormal_coat/hair_pigmentati0.60320079
173MP0002089_abnormal_postnatal_growth/wei0.60051639
174MP0003937_abnormal_limbs/digits/tail_de0.58914961
175MP0004147_increased_porphyrin_level0.58622807
176MP0004084_abnormal_cardiac_muscle0.58108399
177MP0000015_abnormal_ear_pigmentation0.57349826
178MP0009053_abnormal_anal_canal0.57024880
179MP0005389_reproductive_system_phenotype0.56309976
180MP0008789_abnormal_olfactory_epithelium0.56017276
181MP0002429_abnormal_blood_cell0.55521517
182MP0003942_abnormal_urinary_system0.55323276
183MP0003221_abnormal_cardiomyocyte_apopto0.55006244
184MP0002697_abnormal_eye_size0.54914308
185MP0002938_white_spotting0.54514755
186MP0002925_abnormal_cardiovascular_devel0.54142458

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.69101440
2Ependymoma (HP:0002888)4.19630205
3Abnormality of liposaccharide metabolism (HP:0010968)4.16336081
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.16336081
5Abnormality of glycolipid metabolism (HP:0010969)4.16336081
6Chromsome breakage (HP:0040012)3.62847145
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57450843
8Dysostosis multiplex (HP:0000943)3.55794596
9Selective tooth agenesis (HP:0001592)3.40936978
10Distal upper limb amyotrophy (HP:0007149)3.31285559
11Upper limb amyotrophy (HP:0009129)3.31285559
12Vertebral compression fractures (HP:0002953)3.30172853
13Increased cerebral lipofuscin (HP:0011813)3.29630698
14Medulloblastoma (HP:0002885)3.28550983
15Obstructive sleep apnea (HP:0002870)3.19976386
16Reticulocytopenia (HP:0001896)3.17297004
17Patellar aplasia (HP:0006443)3.09826007
18Short 4th metacarpal (HP:0010044)3.07838230
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.07838230
20Abnormality of the thoracic spine (HP:0100711)3.07452040
21Abnormality of the astrocytes (HP:0100707)3.04012267
22Astrocytoma (HP:0009592)3.04012267
23Hand muscle atrophy (HP:0009130)2.96524538
24Short nail (HP:0001799)2.92498478
25Volvulus (HP:0002580)2.92422833
26Increased nuchal translucency (HP:0010880)2.89648131
27Thoracic kyphosis (HP:0002942)2.88212621
28Flat acetabular roof (HP:0003180)2.84901181
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.84727711
30Aplasia/Hypoplasia of the patella (HP:0006498)2.82971607
31Eczematoid dermatitis (HP:0000976)2.82815056
32Broad face (HP:0000283)2.82557649
33Achilles tendon contracture (HP:0001771)2.80799398
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77681236
35Abnormality of polysaccharide metabolism (HP:0011012)2.77681236
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77681236
37Premature graying of hair (HP:0002216)2.77151205
38Basal cell carcinoma (HP:0002671)2.74518003
39Nasal polyposis (HP:0100582)2.74371801
40J-shaped sella turcica (HP:0002680)2.73735923
41Abnormality of the nasal mucosa (HP:0000433)2.73054929
42Abnormality of the distal phalanges of the toes (HP:0010182)2.69795307
43Cervical subluxation (HP:0003308)2.67071574
44Recurrent abscess formation (HP:0002722)2.66013583
45Colon cancer (HP:0003003)2.63909748
46Abnormality of the ileum (HP:0001549)2.63787902
47Rough bone trabeculation (HP:0100670)2.62246401
48Distal lower limb muscle weakness (HP:0009053)2.61102201
49Stridor (HP:0010307)2.60427892
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60223362
51Recurrent bacterial skin infections (HP:0005406)2.58514977
52Urinary glycosaminoglycan excretion (HP:0003541)2.57370000
53Mucopolysacchariduria (HP:0008155)2.57370000
54Meckel diverticulum (HP:0002245)2.54966956
55Slender long bone (HP:0003100)2.51858215
56Glioma (HP:0009733)2.51147074
57Impulsivity (HP:0100710)2.50184816
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.50052116
59Ectopic kidney (HP:0000086)2.49682553
60Agnosia (HP:0010524)2.49387996
61Distal lower limb amyotrophy (HP:0008944)2.49175487
62Abnormality of chromosome stability (HP:0003220)2.47654523
63Proximal placement of thumb (HP:0009623)2.46751206
64Difficulty climbing stairs (HP:0003551)2.45861237
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.45115252
66Abnormal respiratory motile cilium morphology (HP:0005938)2.44858146
67Abnormal respiratory epithelium morphology (HP:0012253)2.44858146
68Oral leukoplakia (HP:0002745)2.43158401
69Increased connective tissue (HP:0009025)2.42546437
70Atelectasis (HP:0100750)2.42316467
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39207073
72Amyloidosis (HP:0011034)2.39034705
73Deviation of the thumb (HP:0009603)2.38320800
74Neoplasm of the pancreas (HP:0002894)2.38032678
75Degeneration of anterior horn cells (HP:0002398)2.37900556
76Abnormality of the anterior horn cell (HP:0006802)2.37900556
77Mitral regurgitation (HP:0001653)2.36060792
78Axonal loss (HP:0003447)2.36018200
79Vacuolated lymphocytes (HP:0001922)2.35119816
80Abnormality of the lower motor neuron (HP:0002366)2.34612824
81Loss of speech (HP:0002371)2.34175394
82Abnormality of macrophages (HP:0004311)2.32608801
83Shoulder girdle muscle weakness (HP:0003547)2.30813482
84Abnormality of the Achilles tendon (HP:0005109)2.29411111
85Duplicated collecting system (HP:0000081)2.29069703
86Abnormal number of incisors (HP:0011064)2.28516486
87Thin bony cortex (HP:0002753)2.28453538
88Absent/shortened dynein arms (HP:0200106)2.25103179
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.25103179
90Abnormality of the renal collecting system (HP:0004742)2.24431710
91Upper motor neuron abnormality (HP:0002127)2.24111176
92Abnormality of the preputium (HP:0100587)2.23464081
93Aplastic anemia (HP:0001915)2.22958322
94Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.22873409
95Myelodysplasia (HP:0002863)2.20616846
96Small intestinal stenosis (HP:0012848)2.20213945
97Duodenal stenosis (HP:0100867)2.20213945
98Long toe (HP:0010511)2.19860258
99Freckling (HP:0001480)2.19743594
100Protrusio acetabuli (HP:0003179)2.19701784
101Joint stiffness (HP:0001387)2.19555668
102Bone marrow hypocellularity (HP:0005528)2.17845647
103Polygenic inheritance (HP:0010982)2.15923769
104Interstitial pulmonary disease (HP:0006530)2.14879795
105Pelvic girdle muscle weakness (HP:0003749)2.13013606
106Abnormality of the 4th metacarpal (HP:0010012)2.13000014
107Abnormality of the labia minora (HP:0012880)2.12976463
108Cafe-au-lait spot (HP:0000957)2.11730288
109Breast hypoplasia (HP:0003187)2.10835455
110Broad distal phalanx of finger (HP:0009836)2.10617164
111Cellulitis (HP:0100658)2.10397217
112Abnormality of DNA repair (HP:0003254)2.09323942
113Biconcave vertebral bodies (HP:0004586)2.09257883
114High pitched voice (HP:0001620)2.09034352
115Broad alveolar ridges (HP:0000187)2.08303173
116Premature rupture of membranes (HP:0001788)2.07185269
11711 pairs of ribs (HP:0000878)2.06253128
118Atresia of the external auditory canal (HP:0000413)2.05134572
119Sloping forehead (HP:0000340)2.04995358
120Preauricular skin tag (HP:0000384)2.03374215
121Neoplasm of striated muscle (HP:0009728)2.03151110
122Aplasia/Hypoplasia of the sternum (HP:0006714)2.03006571
123Absent thumb (HP:0009777)2.02938794
124Short femoral neck (HP:0100864)2.02577647
125Cellular immunodeficiency (HP:0005374)2.01460450
126Rhabdomyosarcoma (HP:0002859)2.01363686
127Broad palm (HP:0001169)2.01317462
128Nephroblastoma (Wilms tumor) (HP:0002667)2.00942199
129Abnormal vertebral ossification (HP:0100569)1.99705417
130Hypertensive crisis (HP:0100735)1.98568135
131Mediastinal lymphadenopathy (HP:0100721)1.98313455
132Increased serum ferritin (HP:0003281)1.96868497
133Skin tags (HP:0010609)1.96417424
134Prominent metopic ridge (HP:0005487)1.95084783
135Neuronal loss in central nervous system (HP:0002529)1.94969726
136Neoplasm of the oral cavity (HP:0100649)1.94752480
137Deformed sella turcica (HP:0002681)1.93307523
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.93230256
139Tracheoesophageal fistula (HP:0002575)1.92447215
140Colitis (HP:0002583)1.90902112
141Centrally nucleated skeletal muscle fibers (HP:0003687)1.90811501
142Abnormality of the calcaneus (HP:0008364)1.89228054
143Fragile skin (HP:0001030)1.89079702
144Abnormality of the carotid arteries (HP:0005344)1.88713038
145Cerebral hypomyelination (HP:0006808)1.88400072
146Embryonal renal neoplasm (HP:0011794)1.88368126
147Pointed chin (HP:0000307)1.87915629
148Arteriovenous malformation (HP:0100026)1.87858595
149Abnormality of chromosome segregation (HP:0002916)1.86793717
150Poikiloderma (HP:0001029)1.86249579
151Abnormality of the hip-girdle musculature (HP:0001445)1.86042657
152Abnormality of the musculature of the pelvis (HP:0001469)1.86042657
153Carpal bone hypoplasia (HP:0001498)1.85584972
154Absent radius (HP:0003974)1.85247556
155Long palpebral fissure (HP:0000637)1.85091433
156Facial cleft (HP:0002006)1.84694065
157Multiple lipomas (HP:0001012)1.84586571
158Cutaneous melanoma (HP:0012056)1.83967176
159Cerebral inclusion bodies (HP:0100314)1.83882175
160Unsteady gait (HP:0002317)1.83603224
161Abnormal respiratory motile cilium physiology (HP:0012261)1.82974271
162Abnormality of the metopic suture (HP:0005556)1.81678242
163Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80890692
164Renal duplication (HP:0000075)1.80844535
165Short thumb (HP:0009778)1.80586157
166Spinal rigidity (HP:0003306)1.79401389
167Bulbar palsy (HP:0001283)1.78443344
168Absent epiphyses (HP:0010577)1.78362377
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78362377
170Cerebral aneurysm (HP:0004944)1.77884529
171Prominent nose (HP:0000448)1.77822702
172Hyperacusis (HP:0010780)1.77803085
173Natal tooth (HP:0000695)1.77598752
174Hemorrhage of the eye (HP:0011885)1.77036296
175Pathologic fracture (HP:0002756)1.76808206
176Benign neoplasm of the central nervous system (HP:0100835)1.76416725
177Abnormality of the duodenum (HP:0002246)1.76105154
178Gingivitis (HP:0000230)1.74967688
179Aplasia/hypoplasia of the femur (HP:0005613)1.74734234
180Angiofibromas (HP:0010615)1.74490666
181Adenoma sebaceum (HP:0009720)1.74490666
182Ulnar bowing (HP:0003031)1.73406286
183Abnormality of the aortic arch (HP:0012303)1.72221648
184Aplasia involving forearm bones (HP:0009822)1.72055890
185Absent forearm bone (HP:0003953)1.72055890
186Abnormality of dentin (HP:0010299)1.69591245
187Neurofibrillary tangles (HP:0002185)1.69286576
188Diaphragmatic weakness (HP:0009113)1.67887531
189Abnormal ciliary motility (HP:0012262)1.67565797
190Chronic obstructive pulmonary disease (HP:0006510)1.67398649
191Obstructive lung disease (HP:0006536)1.67398649
192Genu recurvatum (HP:0002816)1.65557499
193Short clavicles (HP:0000894)1.65555033
194Elevated erythrocyte sedimentation rate (HP:0003565)1.64820495
195Ragged-red muscle fibers (HP:0003200)1.64626422
196Male infertility (HP:0003251)1.63782116
197Supranuclear gaze palsy (HP:0000605)1.63713601
198Recurrent gram-negative bacterial infections (HP:0005420)1.62742316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.58337213
2WEE14.28558956
3BUB14.21122761
4NME23.62294688
5SMG13.40184820
6IRAK33.39790129
7NEK12.93682209
8ERN12.93165285
9CCNB12.86241500
10NEK22.83713214
11EPHA22.53816185
12PRPF4B2.50857193
13SRPK12.46819550
14MAP2K32.33674136
15BCKDK2.30934443
16SIK12.29203336
17MAP3K112.07635214
18ATR2.04179460
19EEF2K2.03161685
20TSSK62.00008277
21PASK1.99793302
22PLK11.89103891
23ACVR1B1.88279773
24TTK1.85413753
25MAP3K101.83098615
26BRSK11.80494891
27MAPK151.80175080
28PRKD21.75889654
29BRSK21.75753655
30TLK11.67377080
31TRIB31.62938896
32TGFBR11.60870699
33PKN21.55552991
34CDK71.53599931
35MAP3K31.51848921
36EIF2AK11.46227097
37AURKB1.43974599
38PLK31.41373805
39CDK121.38525747
40VRK11.38397386
41IRAK41.36787600
42DAPK11.34919656
43RPS6KB21.32861147
44EPHB11.31988666
45SCYL21.31590247
46TESK11.31303323
47PAK41.30998160
48ARAF1.29824115
49CHEK11.26503103
50CDK41.23309641
51TBK11.22875646
52CHEK21.21061014
53AURKA1.20821481
54TESK21.19435159
55CDK81.16237725
56BLK1.15696275
57DYRK31.15374502
58MAP4K11.12942434
59BRD41.12733026
60PIM21.12255579
61PDPK11.11902644
62PDK41.09800461
63PDK31.09800461
64MAP3K81.08702080
65RPS6KA21.08150321
66MARK21.05395073
67PTK61.05001559
68STK101.04967419
69PLK41.00885227
70CDK20.98245777
71TAOK10.97400570
72RPS6KL10.95662364
73RPS6KC10.95662364
74CDC42BPA0.95263732
75ZAP700.95140275
76TYK20.94887687
77MAP3K10.94101209
78TTN0.92250849
79MAP3K130.91270925
80LIMK10.91012550
81ABL20.89442679
82ATM0.87694333
83MAP2K20.87362027
84RIPK40.85256816
85RPS6KA60.81222195
86CSK0.81031454
87HIPK20.80622774
88MAPK110.79443773
89MKNK10.78956225
90TNK20.78888716
91BRAF0.78745711
92CDK10.78217121
93RPS6KA40.75748160
94ICK0.73673394
95LMTK20.73596038
96DYRK20.72171328
97PRKD30.68295964
98BMX0.67136059
99PTK20.65996766
100KSR10.64953900
101CAMKK10.64336429
102CDK180.64239683
103IRAK20.63139975
104MAPK120.62908576
105PDK10.61814282
106CDK190.61727650
107GRK60.60825498
108CDK150.60483296
109EIF2AK30.59953423
110STK40.58248247
111MAP3K70.57651023
112STK380.57082613
113UHMK10.56960532
114MST1R0.56384778
115MOS0.56237681
116MAPKAPK30.56208790
117CDK11A0.55996354
118PAK60.55146720
119ERBB30.55121822
120CSNK2A20.53950263
121FES0.53254218
122NTRK20.52998827
123MTOR0.51730723
124MAP3K140.50618699
125MATK0.50593457
126CDK140.50054938
127RIPK10.49563825
128MINK10.49514565
129CSNK2A10.48811698
130KSR20.48594753
131PAK10.48305243
132AKT20.48006700
133ZAK0.47958166
134VRK20.47574834
135DAPK30.47288990
136ILK0.46070122
137CDK90.45108980
138ALK0.45034231
139DDR20.44811796
140CSNK1E0.44502176
141LATS10.44131228
142IKBKB0.44003481
143DYRK1B0.43822969
144LRRK20.43751423
145MARK10.43371604
146PRKDC0.42789599
147BTK0.42447833
148CSF1R0.42031172
149FGFR40.39430110
150SIK30.39195390
151RPS6KA10.38548570
152FLT30.38320382
153MAP3K60.38309641
154MAPKAPK20.38277154
155CLK10.37613605
156PRKG20.36725672
157PIM10.36203566
158PLK20.36000621
159STK160.35231354
160PRKCI0.34617469
161MAPK140.34253487
162PAK20.34018167
163KIT0.33588232
164CDK60.33013839
165CSNK1D0.32500703
166TAOK20.32181350
167PDGFRA0.31640799
168GSK3B0.31155847
169FGFR10.28482208
170SIK20.27716028
171RPS6KB10.26737583
172AKT10.26261947

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.88957691
2Mismatch repair_Homo sapiens_hsa034304.58631039
3Other glycan degradation_Homo sapiens_hsa005113.78677687
4Spliceosome_Homo sapiens_hsa030403.42407537
5Base excision repair_Homo sapiens_hsa034103.34278645
6Cell cycle_Homo sapiens_hsa041103.22296365
7RNA transport_Homo sapiens_hsa030133.01082814
8Nucleotide excision repair_Homo sapiens_hsa034202.89337394
9Homologous recombination_Homo sapiens_hsa034402.83474531
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.79256211
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65840569
12One carbon pool by folate_Homo sapiens_hsa006702.61456905
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.60841759
14Sulfur relay system_Homo sapiens_hsa041222.57346509
15Proteasome_Homo sapiens_hsa030502.45719859
16Lysosome_Homo sapiens_hsa041422.31095456
17Fanconi anemia pathway_Homo sapiens_hsa034602.26102647
18mRNA surveillance pathway_Homo sapiens_hsa030152.08261410
19Pyrimidine metabolism_Homo sapiens_hsa002402.05252522
20Osteoclast differentiation_Homo sapiens_hsa043801.91351736
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88475015
22RNA polymerase_Homo sapiens_hsa030201.75037504
23Oocyte meiosis_Homo sapiens_hsa041141.73822610
24B cell receptor signaling pathway_Homo sapiens_hsa046621.68944297
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67275548
26Non-homologous end-joining_Homo sapiens_hsa034501.66071687
27Ribosome_Homo sapiens_hsa030101.51080996
28p53 signaling pathway_Homo sapiens_hsa041151.50348604
29Systemic lupus erythematosus_Homo sapiens_hsa053221.46651287
30RNA degradation_Homo sapiens_hsa030181.45292844
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43208579
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42609267
33TNF signaling pathway_Homo sapiens_hsa046681.31341659
34Galactose metabolism_Homo sapiens_hsa000521.29481213
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28718153
36Leishmaniasis_Homo sapiens_hsa051401.28516501
37Viral carcinogenesis_Homo sapiens_hsa052031.27794066
38Basal transcription factors_Homo sapiens_hsa030221.26982342
39Hepatitis C_Homo sapiens_hsa051601.26658204
40Toxoplasmosis_Homo sapiens_hsa051451.22034450
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21703166
42Epstein-Barr virus infection_Homo sapiens_hsa051691.20410055
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20095149
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.19418751
45Tuberculosis_Homo sapiens_hsa051521.18128408
46Purine metabolism_Homo sapiens_hsa002301.13095838
47Endocytosis_Homo sapiens_hsa041441.09667210
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.07975966
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01959322
50Salmonella infection_Homo sapiens_hsa051321.01750861
51Alcoholism_Homo sapiens_hsa050340.99321440
52Prion diseases_Homo sapiens_hsa050200.97799936
53HTLV-I infection_Homo sapiens_hsa051660.97305246
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94798946
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93797674
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.92050600
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.91106470
58Influenza A_Homo sapiens_hsa051640.87869795
59Biosynthesis of amino acids_Homo sapiens_hsa012300.87615483
60Colorectal cancer_Homo sapiens_hsa052100.84937029
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.84497981
62Renal cell carcinoma_Homo sapiens_hsa052110.82935945
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.81190631
64ErbB signaling pathway_Homo sapiens_hsa040120.80204064
65Phagosome_Homo sapiens_hsa041450.80155339
66Insulin resistance_Homo sapiens_hsa049310.78890523
67Amoebiasis_Homo sapiens_hsa051460.78370455
68Vibrio cholerae infection_Homo sapiens_hsa051100.76755272
69MicroRNAs in cancer_Homo sapiens_hsa052060.73694729
70GnRH signaling pathway_Homo sapiens_hsa049120.72693205
71Herpes simplex infection_Homo sapiens_hsa051680.72573026
72Pertussis_Homo sapiens_hsa051330.71923866
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71843044
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71542735
75Antigen processing and presentation_Homo sapiens_hsa046120.69090361
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.68957461
77Focal adhesion_Homo sapiens_hsa045100.68951200
78Pentose phosphate pathway_Homo sapiens_hsa000300.68408728
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68298040
80mTOR signaling pathway_Homo sapiens_hsa041500.68160739
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66223974
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65648318
83Small cell lung cancer_Homo sapiens_hsa052220.65317621
84N-Glycan biosynthesis_Homo sapiens_hsa005100.64774812
85Choline metabolism in cancer_Homo sapiens_hsa052310.62965149
86Selenocompound metabolism_Homo sapiens_hsa004500.62351958
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62255705
88T cell receptor signaling pathway_Homo sapiens_hsa046600.61732765
89MAPK signaling pathway_Homo sapiens_hsa040100.61156106
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59993798
91Malaria_Homo sapiens_hsa051440.59048544
92Prolactin signaling pathway_Homo sapiens_hsa049170.58945641
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.56497827
94Hippo signaling pathway_Homo sapiens_hsa043900.56196012
95Non-small cell lung cancer_Homo sapiens_hsa052230.55065582
96Basal cell carcinoma_Homo sapiens_hsa052170.54860649
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53558463
98Carbon metabolism_Homo sapiens_hsa012000.53164996
99Chronic myeloid leukemia_Homo sapiens_hsa052200.52723939
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52250031
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49946075
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48716736
103HIF-1 signaling pathway_Homo sapiens_hsa040660.48175120
104Synaptic vesicle cycle_Homo sapiens_hsa047210.47400762
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46496677
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.46024154
107Glioma_Homo sapiens_hsa052140.45271691
108Inositol phosphate metabolism_Homo sapiens_hsa005620.44173345
109Chemokine signaling pathway_Homo sapiens_hsa040620.43691643
110Shigellosis_Homo sapiens_hsa051310.43659071
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43643961
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43563038
113Hedgehog signaling pathway_Homo sapiens_hsa043400.43403437
114Apoptosis_Homo sapiens_hsa042100.42235471
115Hepatitis B_Homo sapiens_hsa051610.41252897
116Fructose and mannose metabolism_Homo sapiens_hsa000510.39861408
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38053766
118Glucagon signaling pathway_Homo sapiens_hsa049220.37079397
119Pancreatic cancer_Homo sapiens_hsa052120.36997411
120Insulin signaling pathway_Homo sapiens_hsa049100.36258494
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36249532
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34862250
123Wnt signaling pathway_Homo sapiens_hsa043100.32018573
124Thyroid cancer_Homo sapiens_hsa052160.30789108
125Endometrial cancer_Homo sapiens_hsa052130.30636365
126Legionellosis_Homo sapiens_hsa051340.30270529
127Viral myocarditis_Homo sapiens_hsa054160.28772743
128Pathways in cancer_Homo sapiens_hsa052000.27931960
129VEGF signaling pathway_Homo sapiens_hsa043700.27673713
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26855088
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26723468
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25780301
133Bladder cancer_Homo sapiens_hsa052190.25574955
134AMPK signaling pathway_Homo sapiens_hsa041520.24480284
135Notch signaling pathway_Homo sapiens_hsa043300.24180796
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23226439
137Proteoglycans in cancer_Homo sapiens_hsa052050.22104900
138Gap junction_Homo sapiens_hsa045400.22040823
139Lysine degradation_Homo sapiens_hsa003100.21742906
140Measles_Homo sapiens_hsa051620.19854758
141Primary immunodeficiency_Homo sapiens_hsa053400.19820992
142Adherens junction_Homo sapiens_hsa045200.17681234
143Melanoma_Homo sapiens_hsa052180.17614903
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17146868
145Estrogen signaling pathway_Homo sapiens_hsa049150.17116378
146Long-term potentiation_Homo sapiens_hsa047200.17061138
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16531648
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15679892
149Acute myeloid leukemia_Homo sapiens_hsa052210.15402058
150FoxO signaling pathway_Homo sapiens_hsa040680.13966453
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12553161
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11684280
153Prostate cancer_Homo sapiens_hsa052150.10434688

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