TUBGCP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.64010078
2kinetochore organization (GO:0051383)4.46599724
3nuclear pore complex assembly (GO:0051292)4.41168842
4regulation of DNA endoreduplication (GO:0032875)4.36170246
5mitotic sister chromatid cohesion (GO:0007064)4.09923959
6meiotic chromosome segregation (GO:0045132)4.05368513
7positive regulation of gamma-delta T cell activation (GO:0046645)3.89473125
8mitotic recombination (GO:0006312)3.79300174
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72269837
10nuclear pore organization (GO:0006999)3.71864982
11telomere maintenance via recombination (GO:0000722)3.70259938
12telomere maintenance via semi-conservative replication (GO:0032201)3.65457265
13pore complex assembly (GO:0046931)3.65084711
14DNA replication checkpoint (GO:0000076)3.63547699
15kinetochore assembly (GO:0051382)3.61861250
16histone H3-K4 trimethylation (GO:0080182)3.61084375
17replication fork processing (GO:0031297)3.57775155
18DNA replication initiation (GO:0006270)3.54674197
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.50452551
20DNA synthesis involved in DNA repair (GO:0000731)3.48633723
21pyrimidine dimer repair (GO:0006290)3.45761188
22DNA unwinding involved in DNA replication (GO:0006268)3.45097290
23CENP-A containing nucleosome assembly (GO:0034080)3.43969170
24chromatin remodeling at centromere (GO:0031055)3.39873980
25DNA strand elongation involved in DNA replication (GO:0006271)3.32312047
26water-soluble vitamin biosynthetic process (GO:0042364)3.31899594
27intra-S DNA damage checkpoint (GO:0031573)3.26103310
28DNA topological change (GO:0006265)3.24332668
29interferon-gamma production (GO:0032609)3.23459262
30regulation of centriole replication (GO:0046599)3.22322136
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.22119533
32DNA strand renaturation (GO:0000733)3.20505934
33translesion synthesis (GO:0019985)3.20230787
34DNA strand elongation (GO:0022616)3.17536815
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17034962
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.17034962
37NADH dehydrogenase complex assembly (GO:0010257)3.17034962
38protein complex biogenesis (GO:0070271)3.12530387
39cellular ketone body metabolic process (GO:0046950)3.12442462
40DNA replication-independent nucleosome organization (GO:0034724)3.06929296
41DNA replication-independent nucleosome assembly (GO:0006336)3.06929296
42DNA duplex unwinding (GO:0032508)3.04812642
43DNA geometric change (GO:0032392)3.04639079
44mitochondrial respiratory chain complex assembly (GO:0033108)2.98815878
45mitotic chromosome condensation (GO:0007076)2.96574700
46peptidyl-lysine trimethylation (GO:0018023)2.96075627
47mRNA splice site selection (GO:0006376)2.95337283
48regulation of nuclear cell cycle DNA replication (GO:0033262)2.95110887
49DNA double-strand break processing (GO:0000729)2.94594829
50telomere maintenance via telomere lengthening (GO:0010833)2.94369666
51negative T cell selection (GO:0043383)2.90964587
52double-strand break repair via homologous recombination (GO:0000724)2.88470947
53regulation of histone H3-K9 methylation (GO:0051570)2.86871980
54telomere maintenance (GO:0000723)2.85367516
55histone H3-K4 methylation (GO:0051568)2.85121156
56sister chromatid segregation (GO:0000819)2.83183362
57protein localization to kinetochore (GO:0034501)2.83054657
58microtubule depolymerization (GO:0007019)2.82128770
59respiratory chain complex IV assembly (GO:0008535)2.81395826
60reciprocal meiotic recombination (GO:0007131)2.80991687
61reciprocal DNA recombination (GO:0035825)2.80991687
62tRNA methylation (GO:0030488)2.80163877
63pseudouridine synthesis (GO:0001522)2.78869451
64centriole assembly (GO:0098534)2.78743052
65DNA ligation (GO:0006266)2.78410744
66ketone body metabolic process (GO:1902224)2.78296551
67telomere organization (GO:0032200)2.78016121
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77594181
69negative regulation of translation, ncRNA-mediated (GO:0040033)2.77594181
70regulation of translation, ncRNA-mediated (GO:0045974)2.77594181
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76488737
72protein K6-linked ubiquitination (GO:0085020)2.73791978
73kynurenine metabolic process (GO:0070189)2.73700288
74cilium or flagellum-dependent cell motility (GO:0001539)2.73268681
75ubiquinone biosynthetic process (GO:0006744)2.73141019
76negative thymic T cell selection (GO:0045060)2.72956391
77protein polyglutamylation (GO:0018095)2.72389788
78DNA conformation change (GO:0071103)2.71318456
79response to pheromone (GO:0019236)2.70511024
80DNA deamination (GO:0045006)2.69970183
81metaphase plate congression (GO:0051310)2.68586413
82ubiquinone metabolic process (GO:0006743)2.67899222
83postreplication repair (GO:0006301)2.66799486
84centriole replication (GO:0007099)2.66655604
85negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66365522
86regulation of centrosome duplication (GO:0010824)2.65921921
87protein localization to chromosome, centromeric region (GO:0071459)2.65807915
88histone exchange (GO:0043486)2.64815892
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63296677
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.63296677
91regulation of centrosome cycle (GO:0046605)2.62877319
92sister chromatid cohesion (GO:0007062)2.61682069
93peptidyl-histidine modification (GO:0018202)2.61016739
94regulation of gamma-delta T cell activation (GO:0046643)2.60956962
95protein-cofactor linkage (GO:0018065)2.60896990
96behavioral response to ethanol (GO:0048149)2.60290179
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59537004
98tryptophan catabolic process (GO:0006569)2.59017270
99indole-containing compound catabolic process (GO:0042436)2.59017270
100indolalkylamine catabolic process (GO:0046218)2.59017270
101detection of light stimulus involved in visual perception (GO:0050908)2.58686127
102detection of light stimulus involved in sensory perception (GO:0050962)2.58686127
103attachment of spindle microtubules to kinetochore (GO:0008608)2.57355020
104mitotic sister chromatid segregation (GO:0000070)2.57078162
105negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56524215
106negative regulation of cell killing (GO:0031342)2.56524215
107chromosome segregation (GO:0007059)2.54542869
108indolalkylamine metabolic process (GO:0006586)2.53926171
109DNA catabolic process, exonucleolytic (GO:0000738)2.51956652
110preassembly of GPI anchor in ER membrane (GO:0016254)2.51769524
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51528976
112DNA dealkylation (GO:0035510)2.50711914
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.50288117
114L-fucose catabolic process (GO:0042355)2.50007060
115fucose catabolic process (GO:0019317)2.50007060
116L-fucose metabolic process (GO:0042354)2.50007060
117tRNA modification (GO:0006400)2.48010763
118DNA methylation involved in gamete generation (GO:0043046)2.46439037
119positive regulation of cell cycle checkpoint (GO:1901978)2.45517646
120rRNA modification (GO:0000154)2.45015292
121V(D)J recombination (GO:0033151)2.44444511
122cytochrome complex assembly (GO:0017004)2.43794170
123regulation of gamma-delta T cell differentiation (GO:0045586)2.43509643
124regulation of DNA-dependent DNA replication (GO:0090329)2.42645498
125neural tube formation (GO:0001841)2.42205719
126negative regulation of RNA splicing (GO:0033119)2.42079997
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.41373921
128regulation of mitotic spindle checkpoint (GO:1903504)2.41373921
129negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41200036
130chromatin assembly or disassembly (GO:0006333)2.41082471
131mismatch repair (GO:0006298)2.40817239
132nonmotile primary cilium assembly (GO:0035058)2.40298879
133mitochondrial RNA metabolic process (GO:0000959)2.40166324
134inositol phosphate catabolic process (GO:0071545)2.39982232
135DNA demethylation (GO:0080111)2.39839336
136NIK/NF-kappaB signaling (GO:0038061)2.39606011
137tRNA processing (GO:0008033)2.38669508
138positive regulation of granulocyte differentiation (GO:0030854)2.38636824
139piRNA metabolic process (GO:0034587)2.38534935
140glycerophospholipid catabolic process (GO:0046475)2.38015264
141mitotic metaphase plate congression (GO:0007080)2.36847384
142recombinational repair (GO:0000725)2.34720001
143DNA biosynthetic process (GO:0071897)2.34634553
144DNA recombination (GO:0006310)2.34118869
145axoneme assembly (GO:0035082)2.33064971
146establishment of chromosome localization (GO:0051303)2.33063482
147base-excision repair (GO:0006284)2.32986040
148somite development (GO:0061053)2.32928568
149resolution of meiotic recombination intermediates (GO:0000712)2.31890195
150DNA packaging (GO:0006323)2.31611762
151spinal cord motor neuron differentiation (GO:0021522)2.30780809
152mitotic G2/M transition checkpoint (GO:0044818)2.30734574
153mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.30507661
154B cell homeostasis (GO:0001782)2.30090677
155synapsis (GO:0007129)2.29852756
156regulation of B cell receptor signaling pathway (GO:0050855)2.29345075
157regulation of rhodopsin mediated signaling pathway (GO:0022400)2.27344194
158regulation of neurotransmitter uptake (GO:0051580)2.24644734
159neuronal action potential (GO:0019228)2.24547434
160rRNA methylation (GO:0031167)2.24226574
161establishment of protein localization to mitochondrial membrane (GO:0090151)2.24110576
162cell proliferation in forebrain (GO:0021846)2.24025022
163positive regulation of histone H3-K4 methylation (GO:0051571)2.23559352
164regulation of action potential (GO:0098900)2.23392873
165regulation of meiosis I (GO:0060631)2.22871883
166rRNA catabolic process (GO:0016075)2.22535258
167membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.22508040
168epithelial cilium movement (GO:0003351)2.21794181
169nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.20837924
170amino acid salvage (GO:0043102)2.20752303
171L-methionine salvage (GO:0071267)2.20752303
172L-methionine biosynthetic process (GO:0071265)2.20752303
173rhodopsin mediated signaling pathway (GO:0016056)2.20496368
174protein K11-linked deubiquitination (GO:0035871)2.19995664
175tryptophan metabolic process (GO:0006568)2.19754171
176regulation of cilium movement (GO:0003352)2.19050878
177exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.18973609
178protein neddylation (GO:0045116)2.18696817
179cilium organization (GO:0044782)2.18561625
180ATP synthesis coupled proton transport (GO:0015986)2.18202530
181energy coupled proton transport, down electrochemical gradient (GO:0015985)2.18202530
182regulation of hexokinase activity (GO:1903299)2.18190560
183regulation of glucokinase activity (GO:0033131)2.18190560
184RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.17601181
185dopamine transport (GO:0015872)2.17460201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.84268848
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.43511524
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.06121976
4ZNF274_21170338_ChIP-Seq_K562_Hela3.28352061
5EZH2_22144423_ChIP-Seq_EOC_Human2.93071591
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89804493
7VDR_22108803_ChIP-Seq_LS180_Human2.78653767
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76686621
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74463719
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.70184671
11GBX2_23144817_ChIP-Seq_PC3_Human2.60972641
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.33945008
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.33028881
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.31990759
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.30344956
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28790903
17IGF1R_20145208_ChIP-Seq_DFB_Human2.26834362
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24663140
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.23772852
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22862351
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20592061
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.17012612
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11803289
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11478698
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04074623
26ELK1_19687146_ChIP-ChIP_HELA_Human2.03922947
27E2F7_22180533_ChIP-Seq_HELA_Human11.0431635
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93685436
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89586335
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88747104
31GATA1_22025678_ChIP-Seq_K562_Human1.78705959
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75964430
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75710335
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.75248208
35EWS_26573619_Chip-Seq_HEK293_Human1.74932344
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70914555
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70287012
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.69872979
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69779916
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68911701
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.65851617
42TP53_22573176_ChIP-Seq_HFKS_Human1.65392867
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65382493
44FOXP3_21729870_ChIP-Seq_TREG_Human1.61227029
45IRF1_19129219_ChIP-ChIP_H3396_Human1.60781200
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59350308
47* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58925566
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.57731911
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.55758547
50FUS_26573619_Chip-Seq_HEK293_Human1.55706714
51P300_19829295_ChIP-Seq_ESCs_Human1.54321674
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54052795
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52694005
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51116704
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48698682
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48294673
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47875088
58ER_23166858_ChIP-Seq_MCF-7_Human1.47590782
59VDR_23849224_ChIP-Seq_CD4+_Human1.46630755
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45109792
61RNF2_27304074_Chip-Seq_NSC_Mouse1.42534046
62* REST_21632747_ChIP-Seq_MESCs_Mouse1.41916838
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41345833
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41123207
65MYB_26560356_Chip-Seq_TH1_Human1.38413497
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37158331
67STAT3_23295773_ChIP-Seq_U87_Human1.35614920
68MYB_26560356_Chip-Seq_TH2_Human1.34264139
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32512297
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31903463
71CIITA_25753668_ChIP-Seq_RAJI_Human1.31892528
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31045168
73CBP_20019798_ChIP-Seq_JUKART_Human1.31045168
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30441293
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.30213742
76SPI1_23547873_ChIP-Seq_NB4_Human1.29770224
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29089576
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28877729
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28566128
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27201091
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26577709
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24182588
83SMAD4_21799915_ChIP-Seq_A2780_Human1.24007093
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23837814
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.23527067
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23407324
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21479498
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.20838715
89TCF4_23295773_ChIP-Seq_U87_Human1.20627977
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17534512
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17534512
92AR_25329375_ChIP-Seq_VCAP_Human1.17211929
93TTF2_22483619_ChIP-Seq_HELA_Human1.17165814
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16706382
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.16688502
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16186892
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15953241
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15530746
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15169481
100RUNX_20019798_ChIP-Seq_JUKART_Human1.13392333
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13083247
102CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11467235
103NCOR_22424771_ChIP-Seq_293T_Human1.10890008
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09028656
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08777913
106REST_18959480_ChIP-ChIP_MESCs_Mouse1.08258927
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07466198
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07296426
109AR_21909140_ChIP-Seq_LNCAP_Human1.06794428
110MYC_18940864_ChIP-ChIP_HL60_Human1.05463742
111* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04985390
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04391488
113FOXA1_25329375_ChIP-Seq_VCAP_Human1.04391488
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04064917
115DCP1A_22483619_ChIP-Seq_HELA_Human1.02644960
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02239233
117MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02197862
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01693038
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.01386828
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01264332
121* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00991424
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00925131
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00915269
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00844409
125HOXB7_26014856_ChIP-Seq_BT474_Human1.00077016
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00017493
127PU_27001747_Chip-Seq_BMDM_Mouse1.00004351
128NANOG_19829295_ChIP-Seq_ESCs_Human0.98841242
129SOX2_19829295_ChIP-Seq_ESCs_Human0.98841242
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98504933
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98369741
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98294846
133TCF4_22108803_ChIP-Seq_LS180_Human0.97498998
134BCAT_22108803_ChIP-Seq_LS180_Human0.97441323
135GATA3_21878914_ChIP-Seq_MCF-7_Human0.97319660
136EZH2_27304074_Chip-Seq_ESCs_Mouse0.97220727
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.96287051
138RUNX2_22187159_ChIP-Seq_PCA_Human0.95829385
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.94894751
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93472517
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92930150
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.92274145
143AR_20517297_ChIP-Seq_VCAP_Human0.92251088
144JUN_21703547_ChIP-Seq_K562_Human0.90797838
145IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90603970
146CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90449083
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90379472
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90345019
149SRF_21415370_ChIP-Seq_HL-1_Mouse0.88849124
150CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87991992
151GABP_17652178_ChIP-ChIP_JURKAT_Human0.86494789
152HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86493372
153TFEB_21752829_ChIP-Seq_HELA_Human0.83136934
154XRN2_22483619_ChIP-Seq_HELA_Human0.82811232
155SCL_19346495_ChIP-Seq_HPC-7_Human0.80859150
156MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80072207
157MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79185520
158VDR_21846776_ChIP-Seq_THP-1_Human0.78894311
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78836051
160TAF15_26573619_Chip-Seq_HEK293_Human0.78557128
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78329441
162KDM5A_27292631_Chip-Seq_BREAST_Human0.77513474
163BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76467763
164* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76050873
165FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75183394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.65257639
2MP0010094_abnormal_chromosome_stability3.47142864
3MP0000569_abnormal_digit_pigmentation3.25676882
4MP0008058_abnormal_DNA_repair2.82740188
5MP0003111_abnormal_nucleus_morphology2.75344187
6MP0009697_abnormal_copulation2.68896283
7MP0003693_abnormal_embryo_hatching2.64206653
8MP0008007_abnormal_cellular_replicative2.56668410
9MP0005646_abnormal_pituitary_gland2.29129963
10MP0003077_abnormal_cell_cycle2.23734921
11MP0002396_abnormal_hematopoietic_system2.22270147
12MP0001968_abnormal_touch/_nociception2.19925615
13MP0003763_abnormal_thymus_physiology2.16893343
14MP0005671_abnormal_response_to2.01818794
15MP0005174_abnormal_tail_pigmentation2.00588439
16MP0001835_abnormal_antigen_presentation1.99667744
17MP0006292_abnormal_olfactory_placode1.99572834
18MP0006072_abnormal_retinal_apoptosis1.97202096
19MP0005551_abnormal_eye_electrophysiolog1.95448999
20MP0008877_abnormal_DNA_methylation1.94210090
21MP0003183_abnormal_peptide_metabolism1.92700010
22MP0002234_abnormal_pharynx_morphology1.92442749
23MP0001800_abnormal_humoral_immune1.92106995
24MP0002398_abnormal_bone_marrow1.80907575
25MP0010307_abnormal_tumor_latency1.78727107
26MP0003880_abnormal_central_pattern1.78536941
27MP0000631_abnormal_neuroendocrine_gland1.75456080
28MP0000703_abnormal_thymus_morphology1.73836354
29MP0002837_dystrophic_cardiac_calcinosis1.71202942
30MP0000015_abnormal_ear_pigmentation1.71141030
31MP0002452_abnormal_antigen_presenting1.69075965
32MP0009046_muscle_twitch1.68634433
33MP0009745_abnormal_behavioral_response1.63638208
34MP0005000_abnormal_immune_tolerance1.63599760
35MP0004808_abnormal_hematopoietic_stem1.63171948
36MP0002420_abnormal_adaptive_immunity1.61739590
37MP0002736_abnormal_nociception_after1.60284326
38MP0001819_abnormal_immune_cell1.59760625
39MP0000372_irregular_coat_pigmentation1.56383842
40MP0001790_abnormal_immune_system1.55654182
41MP0005387_immune_system_phenotype1.55654182
42MP0002723_abnormal_immune_serum1.53809949
43MP0003195_calcinosis1.53753011
44MP0003890_abnormal_embryonic-extraembry1.52529745
45MP0002272_abnormal_nervous_system1.52125476
46MP0004885_abnormal_endolymph1.51613411
47MP0001986_abnormal_taste_sensitivity1.49574739
48MP0001984_abnormal_olfaction1.48627775
49MP0003136_yellow_coat_color1.46130526
50MP0002722_abnormal_immune_system1.46064128
51MP0000689_abnormal_spleen_morphology1.46024999
52MP0000490_abnormal_crypts_of1.44275071
53MP0000716_abnormal_immune_system1.44166463
54MP0006276_abnormal_autonomic_nervous1.42314086
55MP0003646_muscle_fatigue1.41675238
56MP0008932_abnormal_embryonic_tissue1.41509358
57MP0005253_abnormal_eye_physiology1.41001080
58MP0001873_stomach_inflammation1.40712041
59MP0004142_abnormal_muscle_tone1.40390429
60MP0008872_abnormal_physiological_respon1.38765830
61MP0004957_abnormal_blastocyst_morpholog1.36825812
62MP0002006_tumorigenesis1.36437018
63MP0000685_abnormal_immune_system1.36177498
64MP0002095_abnormal_skin_pigmentation1.34920060
65MP0003718_maternal_effect1.34847354
66MP0004133_heterotaxia1.33863166
67MP0002876_abnormal_thyroid_physiology1.33248128
68MP0001485_abnormal_pinna_reflex1.32872439
69MP0002163_abnormal_gland_morphology1.31965032
70MP0002429_abnormal_blood_cell1.31842069
71MP0003786_premature_aging1.31062310
72MP0004043_abnormal_pH_regulation1.30937398
73MP0000371_diluted_coat_color1.30118936
74MP0003122_maternal_imprinting1.29809722
75MP0003943_abnormal_hepatobiliary_system1.28517088
76MP0001529_abnormal_vocalization1.28281642
77MP0000427_abnormal_hair_cycle1.28005767
78MP0002557_abnormal_social/conspecific_i1.27528351
79MP0002419_abnormal_innate_immunity1.27268661
80MP0003121_genomic_imprinting1.26515752
81MP0002928_abnormal_bile_duct1.25039472
82MP0000350_abnormal_cell_proliferation1.24961039
83MP0003436_decreased_susceptibility_to1.24107645
84MP0002277_abnormal_respiratory_mucosa1.23550968
85MP0002148_abnormal_hypersensitivity_rea1.18692392
86MP0005410_abnormal_fertilization1.16802124
87MP0009333_abnormal_splenocyte_physiolog1.16313726
88MP0002572_abnormal_emotion/affect_behav1.15661017
89MP0002064_seizures1.15577035
90MP0003698_abnormal_male_reproductive1.15522038
91MP0003635_abnormal_synaptic_transmissio1.14686231
92MP0005171_absent_coat_pigmentation1.14042813
93MP0005187_abnormal_penis_morphology1.13621036
94MP0004145_abnormal_muscle_electrophysio1.12596903
95MP0003937_abnormal_limbs/digits/tail_de1.12550345
96MP0002735_abnormal_chemical_nociception1.12139754
97MP0004742_abnormal_vestibular_system1.11901822
98MP0001929_abnormal_gametogenesis1.10578382
99MP0009785_altered_susceptibility_to1.09861966
100MP0002653_abnormal_ependyma_morphology1.09649825
101MP0002405_respiratory_system_inflammati1.09240323
102MP0005645_abnormal_hypothalamus_physiol1.08483871
103MP0000313_abnormal_cell_death1.08339811
104MP0002166_altered_tumor_susceptibility1.07931197
105MP0001486_abnormal_startle_reflex1.07839132
106MP0002063_abnormal_learning/memory/cond1.07346153
107MP0002075_abnormal_coat/hair_pigmentati1.07262406
108MP0005379_endocrine/exocrine_gland_phen1.06026204
109MP0003119_abnormal_digestive_system1.05990295
110MP0000778_abnormal_nervous_system1.03736971
111MP0003787_abnormal_imprinting1.03020175
112MP0005423_abnormal_somatic_nervous1.02159237
113MP0005075_abnormal_melanosome_morpholog1.02056372
114MP0002184_abnormal_innervation1.01223008
115MP0005386_behavior/neurological_phenoty1.01030696
116MP0004924_abnormal_behavior1.01030696
117MP0005025_abnormal_response_to1.00081460
118MP0002019_abnormal_tumor_incidence0.98500826
119MP0010030_abnormal_orbit_morphology0.97628874
120MP0001293_anophthalmia0.97470096
121MP0002822_catalepsy0.94861385
122MP0001502_abnormal_circadian_rhythm0.94594093
123MP0002160_abnormal_reproductive_system0.93849122
124MP0000566_synostosis0.93525760
125MP0001286_abnormal_eye_development0.93362306
126MP0000653_abnormal_sex_gland0.93242045
127MP0001970_abnormal_pain_threshold0.92871192
128MP0002733_abnormal_thermal_nociception0.92543954
129MP0002067_abnormal_sensory_capabilities0.91824390
130MP0002210_abnormal_sex_determination0.90228579
131MP0001851_eye_inflammation0.90155453
132MP0006035_abnormal_mitochondrial_morpho0.89954889
133MP0000858_altered_metastatic_potential0.89853164
134MP0001188_hyperpigmentation0.88689365
135MP0001905_abnormal_dopamine_level0.88025502
136MP0000049_abnormal_middle_ear0.87744186
137MP0001944_abnormal_pancreas_morphology0.87376569
138MP0002752_abnormal_somatic_nervous0.85886057
139MP0001186_pigmentation_phenotype0.85557577
140MP0002102_abnormal_ear_morphology0.84975224
141MP0008789_abnormal_olfactory_epithelium0.84881091
142MP0004381_abnormal_hair_follicle0.84007271
143MP0004947_skin_inflammation0.83792795
144MP0010386_abnormal_urinary_bladder0.83603518
145MP0008995_early_reproductive_senescence0.83288941
146MP0005389_reproductive_system_phenotype0.81628334
147MP0003283_abnormal_digestive_organ0.81592809
148MP0003123_paternal_imprinting0.81058465
149MP0005195_abnormal_posterior_eye0.80924650
150MP0001845_abnormal_inflammatory_respons0.78737052
151MP0004147_increased_porphyrin_level0.78589963
152MP0002938_white_spotting0.76204137
153MP0002138_abnormal_hepatobiliary_system0.74739790
154MP0005409_darkened_coat_color0.74617178
155MP0001119_abnormal_female_reproductive0.74430020
156MP0001672_abnormal_embryogenesis/_devel0.72584162
157MP0005380_embryogenesis_phenotype0.72584162
158MP0002009_preneoplasia0.72235285
159MP0002638_abnormal_pupillary_reflex0.71916483
160MP0010155_abnormal_intestine_physiology0.71902029
161MP0000465_gastrointestinal_hemorrhage0.71834312
162MP0001145_abnormal_male_reproductive0.71590428
163MP0003172_abnormal_lysosome_physiology0.69966140
164MP0003724_increased_susceptibility_to0.69950248
165MP0005499_abnormal_olfactory_system0.68900386
166MP0005394_taste/olfaction_phenotype0.68900386
167MP0003984_embryonic_growth_retardation0.67549003
168MP0001853_heart_inflammation0.66964441

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.88169991
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.76977321
3Abnormality of the fingertips (HP:0001211)3.64313776
4Pancreatic fibrosis (HP:0100732)3.63715097
5Abnormality of chromosome stability (HP:0003220)3.35993311
6Ectopic kidney (HP:0000086)3.35937409
7Abnormality of the renal cortex (HP:0011035)3.07755277
8Abnormality of DNA repair (HP:0003254)3.01032117
9Abnormality of the renal medulla (HP:0100957)2.89793352
10Aplasia/Hypoplasia of the uvula (HP:0010293)2.75027728
11Chronic hepatic failure (HP:0100626)2.73669023
12Abnormal hair whorl (HP:0010721)2.72580285
13Attenuation of retinal blood vessels (HP:0007843)2.72108938
14Type II lissencephaly (HP:0007260)2.71666007
15Pendular nystagmus (HP:0012043)2.71238510
16Abnormality of B cell number (HP:0010975)2.70893074
17B lymphocytopenia (HP:0010976)2.70893074
18Abnormality of the columella (HP:0009929)2.63343970
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.62508997
20Meckel diverticulum (HP:0002245)2.60389518
21T lymphocytopenia (HP:0005403)2.58929128
22Cystic liver disease (HP:0006706)2.54891610
23Abnormality of the labia minora (HP:0012880)2.51716342
24Duplicated collecting system (HP:0000081)2.51430214
25Abnormality of the preputium (HP:0100587)2.48852364
26Abnormality of T cell number (HP:0011839)2.48802630
27Clubbing of toes (HP:0100760)2.48647502
28Medial flaring of the eyebrow (HP:0010747)2.46863603
29Reticulocytopenia (HP:0001896)2.46302228
30Volvulus (HP:0002580)2.44941438
31Tubulointerstitial nephritis (HP:0001970)2.43300215
32Abnormality of the ileum (HP:0001549)2.43230841
33Abnormality of the renal collecting system (HP:0004742)2.38800816
34Short middle phalanx of the 5th finger (HP:0004220)2.38449951
35Renal cortical cysts (HP:0000803)2.33749915
36Myelodysplasia (HP:0002863)2.33690248
37Optic nerve coloboma (HP:0000588)2.33642248
38Recurrent viral infections (HP:0004429)2.32229299
39Abnormality of the nasal septum (HP:0000419)2.31844688
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30878103
41Abnormality of alanine metabolism (HP:0010916)2.30878103
42Hyperalaninemia (HP:0003348)2.30878103
43Molar tooth sign on MRI (HP:0002419)2.28631705
44Abnormality of midbrain morphology (HP:0002418)2.28631705
45Truncal obesity (HP:0001956)2.25238602
46Gaze-evoked nystagmus (HP:0000640)2.23793708
47Patellar aplasia (HP:0006443)2.23244464
48Acute necrotizing encephalopathy (HP:0006965)2.19495447
49Cerebellar dysplasia (HP:0007033)2.17663447
50Tubular atrophy (HP:0000092)2.17318739
51Polydipsia (HP:0001959)2.17285229
52Abnormal drinking behavior (HP:0030082)2.17285229
53Lip pit (HP:0100267)2.17003112
54Nephroblastoma (Wilms tumor) (HP:0002667)2.16685836
55Sclerocornea (HP:0000647)2.16397366
56Aplasia/Hypoplasia of the patella (HP:0006498)2.15715565
57Abnormality of the carotid arteries (HP:0005344)2.15566322
58Birth length less than 3rd percentile (HP:0003561)2.15396234
59Lissencephaly (HP:0001339)2.15127713
60Acute myeloid leukemia (HP:0004808)2.11570998
61Anal stenosis (HP:0002025)2.10740200
62Methylmalonic acidemia (HP:0002912)2.10066271
63Abnormal biliary tract physiology (HP:0012439)2.09356562
64Bile duct proliferation (HP:0001408)2.09356562
65Increased CSF lactate (HP:0002490)2.08817270
66Hypoplasia of the pons (HP:0012110)2.08783779
67Protruding tongue (HP:0010808)2.08575623
68Recurrent sinusitis (HP:0011108)2.07069828
69Abnormality of the pons (HP:0007361)2.06681514
70Acute lymphatic leukemia (HP:0006721)2.06540366
71Agnosia (HP:0010524)2.06387391
72Recurrent cutaneous fungal infections (HP:0011370)2.05672875
73Chronic mucocutaneous candidiasis (HP:0002728)2.05672875
74Recurrent fungal infections (HP:0002841)2.05615217
75Acute encephalopathy (HP:0006846)2.05459146
76Abnormality of the incisor (HP:0000676)2.03874864
77Abnormality of incisor morphology (HP:0011063)2.03470558
78Abnormal number of incisors (HP:0011064)2.02892512
79Bony spicule pigmentary retinopathy (HP:0007737)2.02656889
80Neoplasm of the adrenal cortex (HP:0100641)2.01862914
81Deep philtrum (HP:0002002)2.01712421
82Oligodactyly (hands) (HP:0001180)2.01106786
83Progressive macrocephaly (HP:0004481)2.00877991
84Mitochondrial inheritance (HP:0001427)2.00676102
85Progressive cerebellar ataxia (HP:0002073)2.00572073
86Colon cancer (HP:0003003)2.00483837
87Hypothermia (HP:0002045)1.99949267
88Mediastinal lymphadenopathy (HP:0100721)1.99776007
89Optic neuritis (HP:0100653)1.98803966
90Retrobulbar optic neuritis (HP:0100654)1.98803966
91Large for gestational age (HP:0001520)1.98656629
92Intestinal atresia (HP:0011100)1.98231475
93Duodenal stenosis (HP:0100867)1.97483164
94Small intestinal stenosis (HP:0012848)1.97483164
95Abnormal rod and cone electroretinograms (HP:0008323)1.97048939
96Embryonal renal neoplasm (HP:0011794)1.97015438
97Anencephaly (HP:0002323)1.96561599
98Severe combined immunodeficiency (HP:0004430)1.96561508
99Hyperventilation (HP:0002883)1.95708058
100Recurrent abscess formation (HP:0002722)1.95001737
101Congenital sensorineural hearing impairment (HP:0008527)1.94956761
102Panhypogammaglobulinemia (HP:0003139)1.93792572
103Abolished electroretinogram (ERG) (HP:0000550)1.93649405
104Encephalitis (HP:0002383)1.93378303
105Thyroiditis (HP:0100646)1.93345313
106Gait imbalance (HP:0002141)1.92479534
107Chronic diarrhea (HP:0002028)1.92053639
108Abnormal mitochondria in muscle tissue (HP:0008316)1.91915589
109Aplasia/Hypoplasia of the earlobes (HP:0009906)1.90971818
110Hepatic necrosis (HP:0002605)1.90776868
111Furrowed tongue (HP:0000221)1.89916443
112Abnormality of T cells (HP:0002843)1.89687046
113Congenital stationary night blindness (HP:0007642)1.88559220
114Absent frontal sinuses (HP:0002688)1.87239549
115Hepatocellular necrosis (HP:0001404)1.86653651
1163-Methylglutaconic aciduria (HP:0003535)1.86290810
117Small hand (HP:0200055)1.85842461
118Long eyelashes (HP:0000527)1.85576521
119Sloping forehead (HP:0000340)1.85505190
120Recurrent pneumonia (HP:0006532)1.85320921
121Eosinophilia (HP:0001880)1.84992812
122Nephrogenic diabetes insipidus (HP:0009806)1.84907281
123True hermaphroditism (HP:0010459)1.84172601
124Congenital primary aphakia (HP:0007707)1.84133937
125Absent thumb (HP:0009777)1.82075263
126Impulsivity (HP:0100710)1.81935083
127IgM deficiency (HP:0002850)1.80723750
128Lymphoma (HP:0002665)1.79999172
129Meningitis (HP:0001287)1.79971898
130Severe muscular hypotonia (HP:0006829)1.79588718
131Polyuria (HP:0000103)1.79527946
132Prominent nose (HP:0000448)1.79379649
133Postaxial foot polydactyly (HP:0001830)1.78677999
134Ketoacidosis (HP:0001993)1.78216887
135Abnormal number of erythroid precursors (HP:0012131)1.78144425
136Optic nerve hypoplasia (HP:0000609)1.78060371
137Febrile seizures (HP:0002373)1.76816022
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.76698443
139Rib fusion (HP:0000902)1.76506373
140Pachygyria (HP:0001302)1.76346963
141Methylmalonic aciduria (HP:0012120)1.75962618
142Chorioretinal atrophy (HP:0000533)1.75961097
143Asplenia (HP:0001746)1.75366624
144Congenital hepatic fibrosis (HP:0002612)1.74318254
145Abnormality of the duodenum (HP:0002246)1.73540135
146Chronic obstructive pulmonary disease (HP:0006510)1.73267391
147Obstructive lung disease (HP:0006536)1.73267391
148Broad-based gait (HP:0002136)1.73234248
149Triphalangeal thumb (HP:0001199)1.72386025
150Increased serum lactate (HP:0002151)1.72120323
151Long nose (HP:0003189)1.71031431
152Supernumerary spleens (HP:0009799)1.70944678
153Male pseudohermaphroditism (HP:0000037)1.70838882
154Hemiparesis (HP:0001269)1.70135760
155Pancreatic cysts (HP:0001737)1.70100527
156Preaxial hand polydactyly (HP:0001177)1.70002332
157Decreased central vision (HP:0007663)1.69362674
158Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68856894
159Hyperglycinemia (HP:0002154)1.68523042
160Ketosis (HP:0001946)1.68335409
161Bone marrow hypocellularity (HP:0005528)1.67805994
162Nephronophthisis (HP:0000090)1.67514958
163Medulloblastoma (HP:0002885)1.66260136
164Poikiloderma (HP:0001029)1.65843600
165Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64645334
166Retinal dysplasia (HP:0007973)1.63840130
167Lymphopenia (HP:0001888)1.63752235
168Median cleft lip (HP:0000161)1.63692804
169Periodontitis (HP:0000704)1.63238813
170Optic disc pallor (HP:0000543)1.63062080
171Thyroid-stimulating hormone excess (HP:0002925)1.62778387
172IgG deficiency (HP:0004315)1.62765462
173Granulocytopenia (HP:0001913)1.62686374
174Recurrent bacterial skin infections (HP:0005406)1.62052166
175Keratoconjunctivitis sicca (HP:0001097)1.62008586
176Heterotopia (HP:0002282)1.61651723
177Abnormality of homocysteine metabolism (HP:0010919)1.60106086
178Homocystinuria (HP:0002156)1.60106086
179Genital tract atresia (HP:0001827)1.60049534
180Gastrointestinal atresia (HP:0002589)1.59499872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.23591101
2CDC73.83993327
3BRD43.28724420
4SRPK12.98374525
5MKNK22.93093201
6ADRBK22.62710223
7TXK2.54948326
8ACVR1B2.41325817
9CDK122.41137265
10WNK42.39522408
11IRAK42.37114579
12MKNK12.34454651
13PNCK2.34206356
14ZAK2.17226367
15TLK12.13401117
16MAP3K142.12461141
17WNK32.09646160
18YES12.03869013
19TRIM281.93596425
20TNIK1.93130570
21MAP3K131.87979039
22ATR1.87124012
23MAP4K11.87080648
24BLK1.82668943
25MAP4K21.82354945
26NEK21.78192900
27RPS6KA41.77996925
28MAP3K41.75033398
29NEK91.64495451
30MAPK131.57730661
31JAK31.49867625
32CASK1.49407450
33BRSK21.46287422
34FGFR21.44164055
35BMPR1B1.41859188
36STK391.40811363
37PLK41.38125566
38WEE11.36758442
39PINK11.35892912
40TGFBR11.35757312
41IKBKB1.29576497
42VRK21.27120278
43MARK11.27048536
44PAK31.21805755
45CLK11.21748491
46DYRK31.21451558
47PHKG21.20370873
48PHKG11.20370873
49VRK11.18878290
50IKBKE1.18008530
51CDK31.17180603
52KIT1.14783984
53PLK21.14173145
54CSNK1G11.13282829
55STK161.12637898
56AURKB1.12633033
57SGK21.09362588
58NTRK31.07624761
59EPHA31.05757340
60OXSR11.04853517
61EIF2AK21.03117709
62CSNK1G31.01712139
63TAF11.01238747
64CSNK1G21.01152132
65TBK10.99956760
66ZAP700.99334015
67ATM0.99078086
68DYRK20.97582037
69PASK0.97178612
70PLK10.96388737
71IRAK30.95907822
72PRKCG0.95528354
73EPHA40.94287550
74CDK70.92419438
75TGFBR20.91799391
76PLK30.91799169
77CHEK10.91059647
78DAPK20.90578877
79NUAK10.88147600
80MELK0.87745335
81RPS6KA50.87560460
82TEC0.87528903
83STK40.86242983
84SYK0.85900716
85LCK0.84850668
86SIK30.81978139
87CCNB10.81857902
88CSNK1A1L0.80596871
89TAOK30.79787625
90CDK40.79326129
91CHUK0.79112202
92EIF2AK30.78702814
93MAP2K70.78599429
94CAMK1G0.78492206
95ERBB30.78278898
96AKT30.77868936
97MAP2K30.76967058
98ADRBK10.75515401
99NTRK20.74657747
100IRAK20.74233556
101INSRR0.74146101
102BUB10.73487677
103LYN0.73434290
104STK100.73125245
105FLT30.72901482
106CDK80.70786892
107MUSK0.70629444
108CDK60.70511200
109DYRK1A0.70030905
110BTK0.69560270
111IRAK10.69485000
112PRKCE0.68303573
113CDK90.67858037
114CHEK20.67609035
115NME10.67038098
116ITK0.66842842
117STK38L0.65065665
118EIF2AK10.63099517
119NEK10.63063267
120MINK10.62212681
121CSNK1E0.61533966
122GRK10.60930729
123SIK20.60649305
124PIM10.60273389
125BCKDK0.60255682
126MAP3K100.60011918
127BCR0.59752063
128NLK0.59662561
129SGK30.59502727
130TYK20.58816778
131RPS6KB10.57882778
132CDK20.56669192
133STK110.56530696
134FGFR30.55382872
135STK30.53878485
136LATS10.51224297
137MAPKAPK50.51159843
138CDK10.50832075
139CAMK1D0.50048853
140CSNK1A10.49727387
141WNK10.48559775
142CAMKK20.48051445
143JAK10.47380680
144TTK0.46862526
145MST40.46803925
146CAMK2A0.45777434
147PRKAA10.44845132
148MAPK70.43828530
149RPS6KA60.42522789
150AKT10.42380646
151BRSK10.42050378
152CSNK1D0.42008540
153PRKCI0.41902820
154PRPF4B0.41078595
155MAP3K70.40997384
156PRKACA0.39831909
157MAP2K60.39690998
158TSSK60.38971235
159PRKDC0.38525052
160RPS6KC10.37024568
161RPS6KL10.37024568

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.59531916
2Homologous recombination_Homo sapiens_hsa034403.52212475
3Fanconi anemia pathway_Homo sapiens_hsa034603.20365850
4Mismatch repair_Homo sapiens_hsa034302.99406076
5Non-homologous end-joining_Homo sapiens_hsa034502.93857973
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.72146632
7Base excision repair_Homo sapiens_hsa034102.62606044
8One carbon pool by folate_Homo sapiens_hsa006702.38116770
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34225299
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.28127638
11Primary immunodeficiency_Homo sapiens_hsa053402.14297974
12Protein export_Homo sapiens_hsa030602.13510069
13Oxidative phosphorylation_Homo sapiens_hsa001902.10535022
14Cell cycle_Homo sapiens_hsa041102.10369608
15Butanoate metabolism_Homo sapiens_hsa006502.07008050
16Spliceosome_Homo sapiens_hsa030402.04294010
17Nucleotide excision repair_Homo sapiens_hsa034201.99833069
18Nitrogen metabolism_Homo sapiens_hsa009101.99257951
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.97392216
20Nicotine addiction_Homo sapiens_hsa050331.97380716
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83174515
22Herpes simplex infection_Homo sapiens_hsa051681.79881770
23Parkinsons disease_Homo sapiens_hsa050121.74814095
24Systemic lupus erythematosus_Homo sapiens_hsa053221.72972644
25Measles_Homo sapiens_hsa051621.71791675
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67118249
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61761204
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56874589
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.54323092
30Basal transcription factors_Homo sapiens_hsa030221.53581465
31Linoleic acid metabolism_Homo sapiens_hsa005911.52398675
32RNA degradation_Homo sapiens_hsa030181.50942388
33Allograft rejection_Homo sapiens_hsa053301.49956614
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48532546
35p53 signaling pathway_Homo sapiens_hsa041151.48140451
36RNA transport_Homo sapiens_hsa030131.47342063
37Hematopoietic cell lineage_Homo sapiens_hsa046401.46999281
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44849520
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42146734
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40724360
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40376520
42Sulfur relay system_Homo sapiens_hsa041221.39121524
43mRNA surveillance pathway_Homo sapiens_hsa030151.38338950
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36573087
45Autoimmune thyroid disease_Homo sapiens_hsa053201.36489620
46Leishmaniasis_Homo sapiens_hsa051401.36476506
47Graft-versus-host disease_Homo sapiens_hsa053321.35407187
48Pyrimidine metabolism_Homo sapiens_hsa002401.34630726
49Propanoate metabolism_Homo sapiens_hsa006401.32299902
50Huntingtons disease_Homo sapiens_hsa050161.29972166
51Lysine degradation_Homo sapiens_hsa003101.25690569
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24308332
53Insulin secretion_Homo sapiens_hsa049111.21430831
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20105164
55T cell receptor signaling pathway_Homo sapiens_hsa046601.18984377
56Olfactory transduction_Homo sapiens_hsa047401.18858157
57Taste transduction_Homo sapiens_hsa047421.17659541
58Tryptophan metabolism_Homo sapiens_hsa003801.12140859
59Epstein-Barr virus infection_Homo sapiens_hsa051691.10588247
60Ether lipid metabolism_Homo sapiens_hsa005651.10451360
61Influenza A_Homo sapiens_hsa051641.10434419
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10039417
63Viral carcinogenesis_Homo sapiens_hsa052031.09328558
64Antigen processing and presentation_Homo sapiens_hsa046121.08717364
65Morphine addiction_Homo sapiens_hsa050321.07709678
66Osteoclast differentiation_Homo sapiens_hsa043801.07678754
67Hepatitis B_Homo sapiens_hsa051611.07364264
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06632592
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05912793
70RNA polymerase_Homo sapiens_hsa030201.05380371
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04252372
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03203298
73Cysteine and methionine metabolism_Homo sapiens_hsa002701.02650739
74Type I diabetes mellitus_Homo sapiens_hsa049401.02547209
75B cell receptor signaling pathway_Homo sapiens_hsa046621.02208167
76TNF signaling pathway_Homo sapiens_hsa046681.02030531
77Alzheimers disease_Homo sapiens_hsa050101.01828773
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01421522
79Cardiac muscle contraction_Homo sapiens_hsa042601.01106272
80HTLV-I infection_Homo sapiens_hsa051660.98923724
81MicroRNAs in cancer_Homo sapiens_hsa052060.93116933
82Apoptosis_Homo sapiens_hsa042100.91666011
83GABAergic synapse_Homo sapiens_hsa047270.91114301
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.90146335
85Peroxisome_Homo sapiens_hsa041460.89504338
86Circadian entrainment_Homo sapiens_hsa047130.87661310
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85872308
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84455736
89Asthma_Homo sapiens_hsa053100.82513421
90Legionellosis_Homo sapiens_hsa051340.80689969
91Prostate cancer_Homo sapiens_hsa052150.80633482
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78702228
93Proteasome_Homo sapiens_hsa030500.77879123
94Glutamatergic synapse_Homo sapiens_hsa047240.77632515
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76724360
96ABC transporters_Homo sapiens_hsa020100.75866319
97Steroid biosynthesis_Homo sapiens_hsa001000.74393992
98Serotonergic synapse_Homo sapiens_hsa047260.72933602
99Fatty acid elongation_Homo sapiens_hsa000620.71786888
100Small cell lung cancer_Homo sapiens_hsa052220.71419593
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71249880
102Chronic myeloid leukemia_Homo sapiens_hsa052200.69980498
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69621440
104Fatty acid metabolism_Homo sapiens_hsa012120.68796820
105Metabolic pathways_Homo sapiens_hsa011000.68018707
106Regulation of autophagy_Homo sapiens_hsa041400.67871973
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67818636
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67613112
109Ribosome_Homo sapiens_hsa030100.66838665
110Pancreatic cancer_Homo sapiens_hsa052120.66154515
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.63956927
112Tuberculosis_Homo sapiens_hsa051520.63859991
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63305403
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.61953611
115Alcoholism_Homo sapiens_hsa050340.61873376
116Acute myeloid leukemia_Homo sapiens_hsa052210.61553656
117Purine metabolism_Homo sapiens_hsa002300.61260424
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60853810
119Collecting duct acid secretion_Homo sapiens_hsa049660.60203852
120Toxoplasmosis_Homo sapiens_hsa051450.59703718
121Dopaminergic synapse_Homo sapiens_hsa047280.57018153
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55578536
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54313520
124Calcium signaling pathway_Homo sapiens_hsa040200.54086435
125Shigellosis_Homo sapiens_hsa051310.53169864
126Retinol metabolism_Homo sapiens_hsa008300.53022948
127Folate biosynthesis_Homo sapiens_hsa007900.52599043
128Circadian rhythm_Homo sapiens_hsa047100.50384015
129Sulfur metabolism_Homo sapiens_hsa009200.49696078
130FoxO signaling pathway_Homo sapiens_hsa040680.49354922
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48987312
132Melanoma_Homo sapiens_hsa052180.48480281
133Fat digestion and absorption_Homo sapiens_hsa049750.48324488
134Phototransduction_Homo sapiens_hsa047440.48234454
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48097630
136Colorectal cancer_Homo sapiens_hsa052100.48001109
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47899570
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47499705
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47277359
140Caffeine metabolism_Homo sapiens_hsa002320.47141206
141Amphetamine addiction_Homo sapiens_hsa050310.46650255
142Ovarian steroidogenesis_Homo sapiens_hsa049130.46309544
143Long-term depression_Homo sapiens_hsa047300.45983160
144Salivary secretion_Homo sapiens_hsa049700.45979432
145Malaria_Homo sapiens_hsa051440.45835379
146Hedgehog signaling pathway_Homo sapiens_hsa043400.45395542
147Pyruvate metabolism_Homo sapiens_hsa006200.44651439
148Cocaine addiction_Homo sapiens_hsa050300.44257157
149beta-Alanine metabolism_Homo sapiens_hsa004100.44218788
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43975630
151Hepatitis C_Homo sapiens_hsa051600.43883657
152Pertussis_Homo sapiens_hsa051330.43848084
153Inositol phosphate metabolism_Homo sapiens_hsa005620.43755396
154Synaptic vesicle cycle_Homo sapiens_hsa047210.43438129
155Selenocompound metabolism_Homo sapiens_hsa004500.43334546
156Glycerolipid metabolism_Homo sapiens_hsa005610.43324318
157Staphylococcus aureus infection_Homo sapiens_hsa051500.39716253
158Chemokine signaling pathway_Homo sapiens_hsa040620.38028652
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36941491
160TGF-beta signaling pathway_Homo sapiens_hsa043500.36906962
161Adherens junction_Homo sapiens_hsa045200.32996677
162Oocyte meiosis_Homo sapiens_hsa041140.31070825
163Non-small cell lung cancer_Homo sapiens_hsa052230.30652329
164Vitamin B6 metabolism_Homo sapiens_hsa007500.29239172
165MAPK signaling pathway_Homo sapiens_hsa040100.28907399
166Viral myocarditis_Homo sapiens_hsa054160.28075581
167Notch signaling pathway_Homo sapiens_hsa043300.26789926
168Pathways in cancer_Homo sapiens_hsa052000.26638153
169Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26467778
170Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26233417
171Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22361851

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