TUFM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)4.80171915
2regulation of translational fidelity (GO:0006450)4.65599748
3ribosomal small subunit biogenesis (GO:0042274)4.63925016
4tricarboxylic acid cycle (GO:0006099)4.62336604
5lysine metabolic process (GO:0006553)4.37476776
6lysine catabolic process (GO:0006554)4.37476776
7COPI coating of Golgi vesicle (GO:0048205)4.36658732
8Golgi transport vesicle coating (GO:0048200)4.36658732
9nucleobase biosynthetic process (GO:0046112)4.36640113
10purine nucleobase biosynthetic process (GO:0009113)4.26825829
11glycine metabolic process (GO:0006544)4.13773559
12NADH metabolic process (GO:0006734)4.10951606
13oxidative phosphorylation (GO:0006119)4.09208706
14protein maturation by protein folding (GO:0022417)4.04040170
15peptidyl-arginine omega-N-methylation (GO:0035247)4.01548137
16folic acid metabolic process (GO:0046655)4.01176742
17regulation of mitochondrial translation (GO:0070129)3.98340301
18folic acid-containing compound biosynthetic process (GO:0009396)3.97231223
19establishment of integrated proviral latency (GO:0075713)3.92882701
20formation of translation preinitiation complex (GO:0001731)3.92624229
21DNA deamination (GO:0045006)3.86593366
22nucleobase-containing small molecule interconversion (GO:0015949)3.77858870
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.76540248
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.74863089
252-oxoglutarate metabolic process (GO:0006103)3.71736936
26DNA strand elongation involved in DNA replication (GO:0006271)3.71339254
27DNA unwinding involved in DNA replication (GO:0006268)3.65455996
28serine family amino acid biosynthetic process (GO:0009070)3.58701599
29oxaloacetate metabolic process (GO:0006107)3.56594825
30regulation of translational termination (GO:0006449)3.49973719
31glyoxylate metabolic process (GO:0046487)3.49062663
32DNA strand elongation (GO:0022616)3.47627000
33ribosomal small subunit assembly (GO:0000028)3.47057024
34IMP biosynthetic process (GO:0006188)3.45042771
35histone arginine methylation (GO:0034969)3.41606331
36mitotic chromosome condensation (GO:0007076)3.38738871
37aspartate family amino acid catabolic process (GO:0009068)3.37179952
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36267407
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35744055
40ATP synthesis coupled proton transport (GO:0015986)3.35744055
41serine family amino acid metabolic process (GO:0009069)3.33998190
42maturation of SSU-rRNA (GO:0030490)3.33434816
43proline metabolic process (GO:0006560)3.31299145
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29931555
45GDP-mannose metabolic process (GO:0019673)3.25283711
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.24704592
47establishment of viral latency (GO:0019043)3.24638166
48telomere maintenance via semi-conservative replication (GO:0032201)3.24446654
49tricarboxylic acid metabolic process (GO:0072350)3.24207383
50DNA replication initiation (GO:0006270)3.23763297
51serine family amino acid catabolic process (GO:0009071)3.23072137
52viral mRNA export from host cell nucleus (GO:0046784)3.20516840
53cotranslational protein targeting to membrane (GO:0006613)3.20373128
54protein targeting to ER (GO:0045047)3.20257376
55NADPH regeneration (GO:0006740)3.17453457
56L-serine metabolic process (GO:0006563)3.15986095
57peptidyl-arginine methylation (GO:0018216)3.14116395
58peptidyl-arginine N-methylation (GO:0035246)3.14116395
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12463753
60IMP metabolic process (GO:0046040)3.10558174
61negative regulation of mRNA processing (GO:0050686)3.09743495
62ribosomal large subunit biogenesis (GO:0042273)3.07914612
63protein localization to endoplasmic reticulum (GO:0070972)3.07361683
64viral transcription (GO:0019083)3.07277605
65viral life cycle (GO:0019058)3.06813047
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06622759
67pteridine-containing compound biosynthetic process (GO:0042559)3.05203065
68amino acid activation (GO:0043038)3.04354006
69tRNA aminoacylation (GO:0043039)3.04354006
70translational termination (GO:0006415)3.03985818
71pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.00676231
72mitochondrial fusion (GO:0008053)2.99895047
73tetrahydrofolate metabolic process (GO:0046653)2.98561922
74L-phenylalanine metabolic process (GO:0006558)2.96683566
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96683566
76ribosome biogenesis (GO:0042254)2.96485768
77* translational elongation (GO:0006414)2.96379695
78branched-chain amino acid catabolic process (GO:0009083)2.95884139
79retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.94915934
80pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.94871724
81valine metabolic process (GO:0006573)2.94591024
82regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.93808629
83regulation of mammary gland epithelial cell proliferation (GO:0033599)2.93752018
84cysteine metabolic process (GO:0006534)2.93389421
85glucose catabolic process (GO:0006007)2.90513270
86translation (GO:0006412)2.89865186
87protein complex localization (GO:0031503)2.89758399
88negative regulation of RNA splicing (GO:0033119)2.89396906
89cellular component biogenesis (GO:0044085)2.89165247
90amino-acid betaine metabolic process (GO:0006577)2.88753677
91nuclear pore complex assembly (GO:0051292)2.88708821
92pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.88684962
93rRNA processing (GO:0006364)2.87725623
94cellular protein complex disassembly (GO:0043624)2.87260398
95mitotic recombination (GO:0006312)2.86941736
96mitotic sister chromatid segregation (GO:0000070)2.86076705
97translational initiation (GO:0006413)2.85287527
98mitotic nuclear envelope reassembly (GO:0007084)2.83628309
99nuclear envelope reassembly (GO:0031468)2.83628309
100folic acid-containing compound metabolic process (GO:0006760)2.83456041
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83455469
102rRNA transcription (GO:0009303)2.83388160
103regulation of translational elongation (GO:0006448)2.81534534
104fatty acid beta-oxidation (GO:0006635)2.81455585
105ribonucleoprotein complex biogenesis (GO:0022613)2.81321001
106guanosine-containing compound biosynthetic process (GO:1901070)2.80965613
107pentose metabolic process (GO:0019321)2.80747403
108protein targeting to mitochondrion (GO:0006626)2.80681216
109kynurenine metabolic process (GO:0070189)2.79213227
110protein retention in ER lumen (GO:0006621)2.78974734
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.77815400
112AMP metabolic process (GO:0046033)2.77397202
113aspartate family amino acid metabolic process (GO:0009066)2.77287446
114protein complex disassembly (GO:0043241)2.75350035
115ribosome assembly (GO:0042255)2.74926376
116monosaccharide biosynthetic process (GO:0046364)2.74893150
117branched-chain amino acid metabolic process (GO:0009081)2.74518687
118ubiquinone biosynthetic process (GO:0006744)2.72410735
119quinone biosynthetic process (GO:1901663)2.72410735
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71872297
121acetyl-CoA metabolic process (GO:0006084)2.70851682
122anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70655679
123sulfur amino acid biosynthetic process (GO:0000097)2.69833749
124regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69089976
125pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.68745745
126nucleoside salvage (GO:0043174)2.68644865
127telomere maintenance via recombination (GO:0000722)2.68462062
128one-carbon metabolic process (GO:0006730)2.67742474
129proteasome assembly (GO:0043248)2.66565230
130sarcomere organization (GO:0045214)2.66400136
131DNA replication checkpoint (GO:0000076)2.65886340
132carnitine metabolic process (GO:0009437)2.65734121
133succinate metabolic process (GO:0006105)2.63945634
134pentose-phosphate shunt (GO:0006098)2.63412379
135mitochondrial RNA metabolic process (GO:0000959)2.62835223
136spliceosomal snRNP assembly (GO:0000387)2.62717091
137regulation of cellular amino acid metabolic process (GO:0006521)2.61109877
138L-methionine salvage (GO:0071267)2.60179437
139L-methionine biosynthetic process (GO:0071265)2.60179437
140amino acid salvage (GO:0043102)2.60179437
141regulation of coenzyme metabolic process (GO:0051196)2.59926456
142regulation of cofactor metabolic process (GO:0051193)2.59926456
143pteridine-containing compound metabolic process (GO:0042558)2.59743046
144L-phenylalanine catabolic process (GO:0006559)2.59530566
145erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.59530566
146pseudouridine synthesis (GO:0001522)2.58745219
147negative regulation of ligase activity (GO:0051352)2.54939909
148negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54939909
149purine nucleoside monophosphate biosynthetic process (GO:0009127)2.54464117
150purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.54464117
151protein localization to kinetochore (GO:0034501)2.53987052
152regulation of acyl-CoA biosynthetic process (GO:0050812)2.53799208
153mitotic nuclear envelope disassembly (GO:0007077)2.52950813
154carnitine shuttle (GO:0006853)2.51704254
155galactose catabolic process (GO:0019388)2.50883801
156pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.50447716
157nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50208912
158L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49435064
159tRNA aminoacylation for protein translation (GO:0006418)2.49209797
160aspartate family amino acid biosynthetic process (GO:0009067)2.48986161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50636061
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.31876762
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.91699190
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.56839806
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.38498180
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90278269
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76262339
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73333297
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.62792842
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59007697
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57081258
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.53090849
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48464768
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.41656843
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.32067530
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18417415
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17077213
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16056535
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11813653
20XRN2_22483619_ChIP-Seq_HELA_Human2.11787810
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10543036
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06345471
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99799337
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.99093636
25AR_21909140_ChIP-Seq_LNCAP_Human1.98066843
26DCP1A_22483619_ChIP-Seq_HELA_Human1.86084703
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83504164
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82453869
29* GABP_19822575_ChIP-Seq_HepG2_Human1.77175394
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71510312
31* VDR_23849224_ChIP-Seq_CD4+_Human1.71420576
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71031090
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68798217
34FOXP3_21729870_ChIP-Seq_TREG_Human1.65955744
35* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65430737
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.61713729
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60671262
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.59816280
39MYC_22102868_ChIP-Seq_BL_Human1.58454194
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57717477
41CIITA_25753668_ChIP-Seq_RAJI_Human1.55695651
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53587017
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51811377
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51122429
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50482072
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49819777
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48847821
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47705200
49ZNF263_19887448_ChIP-Seq_K562_Human1.45546484
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41567463
51LXR_22292898_ChIP-Seq_THP-1_Human1.41263573
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40869894
53TTF2_22483619_ChIP-Seq_HELA_Human1.40806897
54* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38287155
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37791996
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35093526
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35049549
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34790930
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.34731329
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.33932121
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32273448
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30592759
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30325531
64RACK7_27058665_Chip-Seq_MCF-7_Human1.29327916
65* KDM5A_27292631_Chip-Seq_BREAST_Human1.28631062
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26944095
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26768493
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26219112
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.25301719
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25038797
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24804490
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.23726450
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23405078
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22352836
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22285920
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21548288
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21301875
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21042419
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20888687
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20726717
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20446633
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.19549347
83* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15611381
84P68_20966046_ChIP-Seq_HELA_Human1.11202216
85* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09907041
86VDR_21846776_ChIP-Seq_THP-1_Human1.08615753
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08318289
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05650049
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05450954
90* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04974732
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.04675097
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02808391
93* FOXP1_21924763_ChIP-Seq_HESCs_Human1.02404657
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02356892
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02089206
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00855518
97TFEB_21752829_ChIP-Seq_HELA_Human0.99988589
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99904647
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99853429
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99342157
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.99211832
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99070808
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97079315
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96682590
105CLOCK_20551151_ChIP-Seq_293T_Human0.96411212
106* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92074065
107ATF3_27146783_Chip-Seq_COLON_Human0.91611283
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90689523
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89117170
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87383646
111ELK1_19687146_ChIP-ChIP_HELA_Human0.86417699
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86235950
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85753171
114* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85219983
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84759852
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84606618
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84298634
118YY1_22570637_ChIP-Seq_MALME-3M_Human0.83588469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.47664841
2MP0005360_urolithiasis3.73830370
3MP0002139_abnormal_hepatobiliary_system3.55444381
4MP0003693_abnormal_embryo_hatching3.36665563
5MP0003646_muscle_fatigue2.94254991
6MP0005085_abnormal_gallbladder_physiolo2.93663869
7MP0004084_abnormal_cardiac_muscle2.81304930
8MP0002837_dystrophic_cardiac_calcinosis2.79247672
9MP0005365_abnormal_bile_salt2.66434771
10MP0004957_abnormal_blastocyst_morpholog2.65972919
11MP0006036_abnormal_mitochondrial_physio2.55098761
12MP0005058_abnormal_lysosome_morphology2.36670653
13MP0009840_abnormal_foam_cell2.29292848
14MP0003111_abnormal_nucleus_morphology2.27893901
15MP0002877_abnormal_melanocyte_morpholog2.20133339
16MP0005330_cardiomyopathy2.16489699
17MP0008260_abnormal_autophagy2.12616355
18MP0010094_abnormal_chromosome_stability2.09742046
19MP0003077_abnormal_cell_cycle2.05144294
20MP0005501_abnormal_skin_physiology2.02694964
21MP0004185_abnormal_adipocyte_glucose2.02258130
22MP0005332_abnormal_amino_acid1.99885934
23MP0004215_abnormal_myocardial_fiber1.98051395
24MP0008875_abnormal_xenobiotic_pharmacok1.94755710
25MP0003221_abnormal_cardiomyocyte_apopto1.93853586
26MP0003186_abnormal_redox_activity1.90833729
27MP0006035_abnormal_mitochondrial_morpho1.78175958
28MP0000751_myopathy1.76079652
29MP0001730_embryonic_growth_arrest1.75073627
30MP0002796_impaired_skin_barrier1.74650163
31MP0000678_abnormal_parathyroid_gland1.73283601
32MP0010234_abnormal_vibrissa_follicle1.70990644
33MP0003705_abnormal_hypodermis_morpholog1.67083452
34MP0002269_muscular_atrophy1.66601468
35MP0009379_abnormal_foot_pigmentation1.66275142
36MP0000749_muscle_degeneration1.64499981
37MP0004036_abnormal_muscle_relaxation1.63665404
38MP0001661_extended_life_span1.63261342
39MP0005083_abnormal_biliary_tract1.62142253
40MP0010030_abnormal_orbit_morphology1.60371270
41MP0005319_abnormal_enzyme/_coenzyme1.60160759
42MP0010329_abnormal_lipoprotein_level1.60075329
43MP0000750_abnormal_muscle_regeneration1.57243592
44MP0003567_abnormal_fetal_cardiomyocyte1.46979767
45MP0001849_ear_inflammation1.46438818
46MP0010352_gastrointestinal_tract_polyps1.45351778
47MP0003315_abnormal_perineum_morphology1.44180710
48MP0004087_abnormal_muscle_fiber1.42585033
49MP0010630_abnormal_cardiac_muscle1.39613466
50MP0003252_abnormal_bile_duct1.38346144
51MP0001544_abnormal_cardiovascular_syste1.36691028
52MP0005385_cardiovascular_system_phenoty1.36691028
53MP0000537_abnormal_urethra_morphology1.36503505
54MP0008775_abnormal_heart_ventricle1.34676277
55MP0003123_paternal_imprinting1.32439238
56MP0005266_abnormal_metabolism1.31739026
57MP0005670_abnormal_white_adipose1.31413773
58MP0000609_abnormal_liver_physiology1.29314930
59MP0003984_embryonic_growth_retardation1.27609180
60MP0001764_abnormal_homeostasis1.27178489
61MP0002088_abnormal_embryonic_growth/wei1.25457699
62MP0008932_abnormal_embryonic_tissue1.22854393
63MP0009643_abnormal_urine_homeostasis1.22329205
64MP0001672_abnormal_embryogenesis/_devel1.22095268
65MP0005380_embryogenesis_phenotype1.22095268
66MP0008058_abnormal_DNA_repair1.21828036
67MP0002396_abnormal_hematopoietic_system1.21508574
68MP0001666_abnormal_nutrient_absorption1.19772253
69MP0004858_abnormal_nervous_system1.18764588
70MP0006138_congestive_heart_failure1.15906682
71MP0005076_abnormal_cell_differentiation1.15064048
72MP0005451_abnormal_body_composition1.15052053
73MP0000747_muscle_weakness1.13835515
74MP0004233_abnormal_muscle_weight1.13194519
75MP0002972_abnormal_cardiac_muscle1.12253941
76MP0001727_abnormal_embryo_implantation1.11045642
77MP0002080_prenatal_lethality1.10707470
78MP0008007_abnormal_cellular_replicative1.10123304
79MP0008057_abnormal_DNA_replication1.09421648
80MP0000598_abnormal_liver_morphology1.09164318
81MP0003656_abnormal_erythrocyte_physiolo1.09017327
82MP0001881_abnormal_mammary_gland1.08867669
83MP0003191_abnormal_cellular_cholesterol1.08385709
84MP0000358_abnormal_cell_content/1.07408139
85MP0000350_abnormal_cell_proliferation1.07117854
86MP0001697_abnormal_embryo_size1.07032300
87MP0004130_abnormal_muscle_cell1.06061574
88MP0005584_abnormal_enzyme/coenzyme_acti1.04510485
89MP0005666_abnormal_adipose_tissue1.04201843
90MP0002089_abnormal_postnatal_growth/wei1.03581713
91MP0005408_hypopigmentation1.03055211
92MP0004782_abnormal_surfactant_physiolog0.99432777
93MP0004019_abnormal_vitamin_homeostasis0.97047464
94MP0003137_abnormal_impulse_conducting0.95571902
95MP0000003_abnormal_adipose_tissue0.94421468
96MP0003718_maternal_effect0.93825756
97MP0002084_abnormal_developmental_patter0.93660515
98MP0002106_abnormal_muscle_physiology0.92881626
99MP0005384_cellular_phenotype0.92619526
100MP0004147_increased_porphyrin_level0.92312256
101MP0002118_abnormal_lipid_homeostasis0.91201302
102MP0004264_abnormal_extraembryonic_tissu0.90954887
103MP0003453_abnormal_keratinocyte_physiol0.88143765
104MP0003195_calcinosis0.87658444
105MP0009672_abnormal_birth_weight0.87122805
106MP0002086_abnormal_extraembryonic_tissu0.85318046
107MP0000490_abnormal_crypts_of0.85261547
108MP0001853_heart_inflammation0.85098164
109MP0010307_abnormal_tumor_latency0.85071140
110MP0005620_abnormal_muscle_contractility0.84507110
111MP0005375_adipose_tissue_phenotype0.84337385
112MP0002249_abnormal_larynx_morphology0.84116375
113MP0001346_abnormal_lacrimal_gland0.83790787
114MP0000858_altered_metastatic_potential0.83661214
115MP0003566_abnormal_cell_adhesion0.83551419
116MP0006054_spinal_hemorrhage0.82669958
117MP0001873_stomach_inflammation0.81880176
118MP0009697_abnormal_copulation0.79035199
119MP0005636_abnormal_mineral_homeostasis0.78868432
120MP0005621_abnormal_cell_physiology0.78693276
121MP0002019_abnormal_tumor_incidence0.78426279
122MP0000313_abnormal_cell_death0.77623346
123MP0002127_abnormal_cardiovascular_syste0.76858130
124MP0000566_synostosis0.76809281
125MP0005376_homeostasis/metabolism_phenot0.76181870
126MP0009333_abnormal_splenocyte_physiolog0.75818654
127MP0002138_abnormal_hepatobiliary_system0.74997492
128MP0001756_abnormal_urination0.74499818
129MP0000759_abnormal_skeletal_muscle0.74326965
130MP0001216_abnormal_epidermal_layer0.73749364
131MP0000627_abnormal_mammary_gland0.73315468
132MP0000467_abnormal_esophagus_morphology0.72485386
133MP0004197_abnormal_fetal_growth/weight/0.71806353
134MP0000266_abnormal_heart_morphology0.71070856
135MP0003786_premature_aging0.70756594
136MP0002970_abnormal_white_adipose0.70052284
137MP0003828_pulmonary_edema0.69340857
138MP0004808_abnormal_hematopoietic_stem0.68736460
139MP0009278_abnormal_bone_marrow0.68081931
140MP0002060_abnormal_skin_morphology0.67044230
141MP0000477_abnormal_intestine_morphology0.65970887
142MP0003941_abnormal_skin_development0.65549701
143MP0002085_abnormal_embryonic_tissue0.65488442
144MP0009053_abnormal_anal_canal0.64722864

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)4.11561905
2Abnormal gallbladder physiology (HP:0012438)4.11561905
3Microvesicular hepatic steatosis (HP:0001414)4.06226202
4Hyperglycinuria (HP:0003108)3.97071621
5Rhabdomyolysis (HP:0003201)3.92855801
6Myoglobinuria (HP:0002913)3.78540461
7Hepatic necrosis (HP:0002605)3.73774081
8Abnormality of fatty-acid metabolism (HP:0004359)3.64812853
9* Hyperammonemia (HP:0001987)3.61325808
10Multiple enchondromatosis (HP:0005701)3.59770136
11Abnormality of glycolysis (HP:0004366)3.56716376
12Increased serum pyruvate (HP:0003542)3.56716376
13Dicarboxylic aciduria (HP:0003215)3.56057777
14Abnormality of dicarboxylic acid metabolism (HP:0010995)3.56057777
15Abnormality of glycine metabolism (HP:0010895)3.50189965
16Abnormality of serine family amino acid metabolism (HP:0010894)3.50189965
17Hyperglycinemia (HP:0002154)3.36005908
18Hypoglycemic coma (HP:0001325)3.34545941
19Hepatocellular necrosis (HP:0001404)3.23444334
20Hypobetalipoproteinemia (HP:0003563)3.22577087
21Cerebral edema (HP:0002181)3.17920223
22Ketosis (HP:0001946)3.17869565
23Ventricular tachycardia (HP:0004756)3.14177588
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.08658107
25Ragged-red muscle fibers (HP:0003200)3.05109371
26Exercise-induced muscle cramps (HP:0003710)3.04562107
27Nausea (HP:0002018)2.99472019
28Palpitations (HP:0001962)2.99057216
29Acute encephalopathy (HP:0006846)2.96891790
30Trismus (HP:0000211)2.93855473
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.93836037
32Sudden death (HP:0001699)2.93373639
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91956415
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91956415
35Abnormal mitochondria in muscle tissue (HP:0008316)2.91702910
36Abnormality of cells of the erythroid lineage (HP:0012130)2.91059909
37Ketoacidosis (HP:0001993)2.89634755
38Increased serum lactate (HP:0002151)2.88864637
39Abnormality of pyrimidine metabolism (HP:0004353)2.88395471
40Abnormal number of erythroid precursors (HP:0012131)2.88358599
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87699069
42Increased CSF lactate (HP:0002490)2.87522027
43Lethargy (HP:0001254)2.86564556
44Increased muscle lipid content (HP:0009058)2.85954256
45* Lactic acidosis (HP:0003128)2.79516632
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.77350070
47Acute necrotizing encephalopathy (HP:0006965)2.72029149
48Generalized aminoaciduria (HP:0002909)2.66606054
49Abnormality of serum amino acid levels (HP:0003112)2.65925215
50Gout (HP:0001997)2.60616678
51Hyperacusis (HP:0010780)2.60559651
52Mitochondrial inheritance (HP:0001427)2.59648685
53Oral leukoplakia (HP:0002745)2.54653282
54Rough bone trabeculation (HP:0100670)2.51852744
55Intrahepatic cholestasis (HP:0001406)2.48971697
56Lipoatrophy (HP:0100578)2.48593339
57Myopathic facies (HP:0002058)2.46928702
58Vertebral compression fractures (HP:0002953)2.46498052
59Xanthomatosis (HP:0000991)2.46402557
60Increased intramyocellular lipid droplets (HP:0012240)2.45832410
61CNS demyelination (HP:0007305)2.43143429
62Abnormality of alanine metabolism (HP:0010916)2.42370505
63Hyperalaninemia (HP:0003348)2.42370505
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42370505
65Centrally nucleated skeletal muscle fibers (HP:0003687)2.42099461
66Progressive external ophthalmoplegia (HP:0000590)2.40094061
67Hypolipoproteinemia (HP:0010981)2.39874430
68Type I transferrin isoform profile (HP:0003642)2.38748014
69Achilles tendon contracture (HP:0001771)2.37115065
70Progressive muscle weakness (HP:0003323)2.35559586
71Reticulocytopenia (HP:0001896)2.33773645
72Abnormality of the umbilical cord (HP:0010881)2.33147438
73Deep venous thrombosis (HP:0002625)2.32616647
74Spastic diplegia (HP:0001264)2.31923303
75Cholelithiasis (HP:0001081)2.28891376
76* Metabolic acidosis (HP:0001942)2.27849414
77Insomnia (HP:0100785)2.27185796
78Proximal tubulopathy (HP:0000114)2.25672490
79Lipid accumulation in hepatocytes (HP:0006561)2.25119927
80Testicular atrophy (HP:0000029)2.25061367
81Right ventricular cardiomyopathy (HP:0011663)2.24818319
82Respiratory failure (HP:0002878)2.24630489
83Selective tooth agenesis (HP:0001592)2.23450596
84Birth length less than 3rd percentile (HP:0003561)2.22571169
85Abnormal cartilage morphology (HP:0002763)2.22373067
86Abnormality of nucleobase metabolism (HP:0010932)2.20449809
87Late onset (HP:0003584)2.20302312
88Exercise intolerance (HP:0003546)2.18775874
89Conjunctival hamartoma (HP:0100780)2.17855694
90Dilated cardiomyopathy (HP:0001644)2.17678119
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15904345
92Abnormality of sulfur amino acid metabolism (HP:0004339)2.14323413
93Adenoma sebaceum (HP:0009720)2.13560356
94Angiofibromas (HP:0010615)2.13560356
95Abnormality of the Achilles tendon (HP:0005109)2.12719382
96Delayed CNS myelination (HP:0002188)2.11927569
97Exercise-induced myalgia (HP:0003738)2.11856498
98Truncus arteriosus (HP:0001660)2.11469040
99Cerebral hypomyelination (HP:0006808)2.11148675
100Muscle fiber splitting (HP:0003555)2.10913651
101Broad distal phalanx of finger (HP:0009836)2.09711041
102Seborrheic dermatitis (HP:0001051)2.09321683
103Reduced antithrombin III activity (HP:0001976)2.08453152
104Vomiting (HP:0002013)2.08069975
105Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07524593
106Abnormality of glutamine family amino acid metabolism (HP:0010902)2.07387475
107Microretrognathia (HP:0000308)2.05362643
108Abnormality of reticulocytes (HP:0004312)2.05225399
109Secondary amenorrhea (HP:0000869)2.03373752
110Spastic paraparesis (HP:0002313)2.01785806
111Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01735371
112Neoplasm of the adrenal gland (HP:0100631)2.01342533
113Macrocytic anemia (HP:0001972)2.00747364
114Esophageal neoplasm (HP:0100751)2.00687275
115Neoplasm of head and neck (HP:0012288)2.00687275
116Premature ovarian failure (HP:0008209)1.99641891
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99551776
118Progressive macrocephaly (HP:0004481)1.99001992
119Hyperbilirubinemia (HP:0002904)1.98364324
120Hypokinesia (HP:0002375)1.98298706
121Abnormality of urine glucose concentration (HP:0011016)1.95361578
122Glycosuria (HP:0003076)1.95361578
123Long palpebral fissure (HP:0000637)1.95199641
124Megaloblastic anemia (HP:0001889)1.94043993
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93437581
126Hyperuricemia (HP:0002149)1.92791821
127Increased purine levels (HP:0004368)1.92791821
128Abnormality of the gallbladder (HP:0005264)1.92456118
129Abnormality of methionine metabolism (HP:0010901)1.91149125
130Abnormal gallbladder morphology (HP:0012437)1.90965571
131Abnormal trabecular bone morphology (HP:0100671)1.90916083
132Proximal placement of thumb (HP:0009623)1.90844475
133Calf muscle hypertrophy (HP:0008981)1.90596788
134Distal lower limb muscle weakness (HP:0009053)1.89310453
135Reticulocytosis (HP:0001923)1.89167010
136Abnormality of the anterior horn cell (HP:0006802)1.89056986
137Degeneration of anterior horn cells (HP:0002398)1.89056986
138Premature skin wrinkling (HP:0100678)1.89020279
139Squamous cell carcinoma (HP:0002860)1.88519838
140Abnormalities of placenta or umbilical cord (HP:0001194)1.88222279
141Chromsome breakage (HP:0040012)1.86534084
142Abnormality of purine metabolism (HP:0004352)1.86476977
143Hypoalphalipoproteinemia (HP:0003233)1.86166014
144Deviation of the thumb (HP:0009603)1.84414564
145Abnormal protein N-linked glycosylation (HP:0012347)1.83926155
146Abnormal protein glycosylation (HP:0012346)1.83926155
147Abnormal glycosylation (HP:0012345)1.83926155
148Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83926155
149Back pain (HP:0003418)1.83792641
150Abnormality of the tricuspid valve (HP:0001702)1.83555317
151Abnormal umbilical cord blood vessels (HP:0011403)1.80341078
152Single umbilical artery (HP:0001195)1.80341078
153Abnormality of the fetal cardiovascular system (HP:0010948)1.80341078
154Hypertensive crisis (HP:0100735)1.79292949
155Entropion (HP:0000621)1.78334536
156Sparse eyelashes (HP:0000653)1.75820603
157Fasciculations (HP:0002380)1.74904845
158Pallor (HP:0000980)1.73940844
159Abnormality of the distal phalanges of the toes (HP:0010182)1.73052798
160Distal lower limb amyotrophy (HP:0008944)1.72959919
161Septate vagina (HP:0001153)1.72789350
162Hyperthyroidism (HP:0000836)1.71952434
163Upper limb amyotrophy (HP:0009129)1.71822700
164Distal upper limb amyotrophy (HP:0007149)1.71822700
165Pili torti (HP:0003777)1.70781791
166Increased connective tissue (HP:0009025)1.69927494
167Respiratory difficulties (HP:0002880)1.68567425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.40262327
2BUB13.89285268
3NEK13.76558411
4SMG13.33571515
5PKN23.33028511
6WEE13.22077741
7NME23.14267158
8VRK23.04487508
9EIF2AK12.87505236
10TRIB32.61294684
11PBK2.60237509
12PDK42.39171599
13PDK32.39171599
14IRAK32.32532657
15TTN2.13661215
16CDC72.11951798
17NEK21.99128127
18ICK1.92647153
19TSSK61.78747759
20KDR1.78484686
21ACVR1B1.73480851
22FLT31.71749302
23MAP2K31.60286571
24MST1R1.59463529
25ARAF1.57572052
26MAP3K101.51988811
27TESK21.48936281
28TTK1.47408730
29MYLK1.44789435
30MAP3K111.40905352
31OBSCN1.36157381
32EIF2AK31.35719172
33TGFBR11.34675765
34STK161.33855753
35EEF2K1.24347465
36PDK21.23659720
37RPS6KA41.20322533
38MAP3K81.19109700
39BRSK21.18904980
40CDK41.18063203
41ERN11.16738557
42LRRK21.14843411
43AURKB1.14693214
44PAK41.12849322
45PLK11.12771626
46DYRK31.11089413
47LMTK21.10517924
48RPS6KB21.10243324
49PASK1.09925359
50CDK121.07768725
51CCNB11.06019676
52TAOK21.05917039
53MAP3K31.05891841
54CDK71.04074095
55SCYL21.03187993
56SRPK11.02555227
57STK41.01253942
58PRPF4B0.99655762
59ILK0.98001773
60CDK80.94662145
61MAPKAPK30.94418476
62BRSK10.91963932
63AURKA0.88926106
64PIM20.88169026
65STK38L0.87930735
66ATR0.83339262
67EPHA20.82377767
68LIMK10.81360610
69DAPK10.74245004
70STK100.73300178
71MAP4K10.72197932
72NME10.72162040
73TESK10.70144689
74FGFR40.69566354
75MAP3K50.68367455
76CLK10.67877936
77STK240.67045718
78AKT20.63543486
79MAPK110.63253790
80PHKG10.60356789
81PHKG20.60356789
82MAP2K60.60062517
83PLK40.57472375
84CSNK2A20.57247401
85PRKD30.57086088
86CDK190.55236854
87ABL20.54564602
88VRK10.54256925
89CHEK10.53480834
90ZAP700.53347516
91CSNK2A10.52706890
92NEK90.52048391
93TIE10.51794931
94PINK10.51420328
95CDK11A0.50485591
96ZAK0.50215623
97RAF10.49098408
98DAPK30.48917794
99SIK10.48622101
100PAK10.48471057
101GRK60.47551616
102PLK30.47481623
103KSR20.45437774
104PTK20.44951790
105TYK20.44268180
106PTK60.44100230
107BRAF0.44036083
108TLK10.43474297
109CDK10.42975485
110TBK10.42301850
111CDK150.41811931
112CDK140.41535147
113MTOR0.40611687
114MAPKAPK50.40159534
115CDK180.37933251
116PRKCI0.37210746
117PIM10.37109777
118CSNK1G30.36562555
119CHEK20.36063267
120CDK20.35929385
121MET0.34827017
122MAP2K20.34768768
123CDK90.32735354
124ATM0.32481402
125BMX0.31148927
126ERBB40.30364963
127ALK0.29709052
128TAOK10.27158687
129FGFR10.25857448
130RPS6KC10.25718013

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.71266395
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.54487197
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90102917
4DNA replication_Homo sapiens_hsa030302.79877323
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75621335
6Proteasome_Homo sapiens_hsa030502.53513223
7Carbon metabolism_Homo sapiens_hsa012002.42691884
8Propanoate metabolism_Homo sapiens_hsa006402.28520889
9Fatty acid degradation_Homo sapiens_hsa000712.27328597
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16641091
11Ribosome_Homo sapiens_hsa030102.13619884
12Biosynthesis of amino acids_Homo sapiens_hsa012302.11776547
13Mismatch repair_Homo sapiens_hsa034302.09577719
14One carbon pool by folate_Homo sapiens_hsa006702.06183733
15Pyruvate metabolism_Homo sapiens_hsa006201.89355295
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83479144
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.82963004
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74801715
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73257103
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63824333
21RNA polymerase_Homo sapiens_hsa030201.61807481
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.58987537
23Base excision repair_Homo sapiens_hsa034101.56267796
24Pyrimidine metabolism_Homo sapiens_hsa002401.56232717
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.54786166
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.54509940
27Arginine biosynthesis_Homo sapiens_hsa002201.52839799
28Fatty acid metabolism_Homo sapiens_hsa012121.51572773
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50591302
30Selenocompound metabolism_Homo sapiens_hsa004501.49341599
31Sulfur relay system_Homo sapiens_hsa041221.48888417
32Tryptophan metabolism_Homo sapiens_hsa003801.48746049
33Parkinsons disease_Homo sapiens_hsa050121.48013469
34Spliceosome_Homo sapiens_hsa030401.47109645
35RNA transport_Homo sapiens_hsa030131.44560031
36Pentose phosphate pathway_Homo sapiens_hsa000301.43269444
37Folate biosynthesis_Homo sapiens_hsa007901.39620725
38Butanoate metabolism_Homo sapiens_hsa006501.38409810
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36001012
40Oxidative phosphorylation_Homo sapiens_hsa001901.31320555
41Nucleotide excision repair_Homo sapiens_hsa034201.24006457
42Peroxisome_Homo sapiens_hsa041461.22487177
43N-Glycan biosynthesis_Homo sapiens_hsa005101.18807766
44beta-Alanine metabolism_Homo sapiens_hsa004101.17630725
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14857965
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13619954
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12474984
48Homologous recombination_Homo sapiens_hsa034401.11344647
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08617308
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07132090
51PPAR signaling pathway_Homo sapiens_hsa033201.01196736
52Other glycan degradation_Homo sapiens_hsa005110.99577384
53Huntingtons disease_Homo sapiens_hsa050160.98698176
54Fructose and mannose metabolism_Homo sapiens_hsa000510.98641986
55Glutathione metabolism_Homo sapiens_hsa004800.98377276
56Phenylalanine metabolism_Homo sapiens_hsa003600.97979652
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97162119
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95649418
59Nitrogen metabolism_Homo sapiens_hsa009100.93275391
60Arginine and proline metabolism_Homo sapiens_hsa003300.90575704
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86405694
62Cell cycle_Homo sapiens_hsa041100.84631821
63Galactose metabolism_Homo sapiens_hsa000520.79705242
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79452351
65Fat digestion and absorption_Homo sapiens_hsa049750.79234799
66Starch and sucrose metabolism_Homo sapiens_hsa005000.77063926
67Vitamin B6 metabolism_Homo sapiens_hsa007500.75633675
68Steroid biosynthesis_Homo sapiens_hsa001000.74812308
69Cardiac muscle contraction_Homo sapiens_hsa042600.74696714
70Caffeine metabolism_Homo sapiens_hsa002320.71471771
71Fatty acid elongation_Homo sapiens_hsa000620.69568355
72Bladder cancer_Homo sapiens_hsa052190.68673432
73Purine metabolism_Homo sapiens_hsa002300.68605373
74Tyrosine metabolism_Homo sapiens_hsa003500.68234537
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66549739
76Chemical carcinogenesis_Homo sapiens_hsa052040.66164923
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65936943
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65724306
79Alzheimers disease_Homo sapiens_hsa050100.65622440
80Vibrio cholerae infection_Homo sapiens_hsa051100.65249411
81Metabolic pathways_Homo sapiens_hsa011000.64463778
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64312899
83RNA degradation_Homo sapiens_hsa030180.58738670
84Complement and coagulation cascades_Homo sapiens_hsa046100.55290665
85Lysine degradation_Homo sapiens_hsa003100.52113702
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49795866
87Histidine metabolism_Homo sapiens_hsa003400.43743670
88Chronic myeloid leukemia_Homo sapiens_hsa052200.40689287
89p53 signaling pathway_Homo sapiens_hsa041150.38544750
90Retinol metabolism_Homo sapiens_hsa008300.37722570
91Vitamin digestion and absorption_Homo sapiens_hsa049770.36047169
92Prion diseases_Homo sapiens_hsa050200.35803510
93Shigellosis_Homo sapiens_hsa051310.35163987
94Viral carcinogenesis_Homo sapiens_hsa052030.33975203
95mRNA surveillance pathway_Homo sapiens_hsa030150.33807382
96Sulfur metabolism_Homo sapiens_hsa009200.33732796
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.33364078
98Epstein-Barr virus infection_Homo sapiens_hsa051690.32422803
99Bile secretion_Homo sapiens_hsa049760.32036060
100Apoptosis_Homo sapiens_hsa042100.31404502
101Non-homologous end-joining_Homo sapiens_hsa034500.31300675
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30078254
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29750902
104Glycerolipid metabolism_Homo sapiens_hsa005610.29679711
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.29366661
106Acute myeloid leukemia_Homo sapiens_hsa052210.29245823
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28408985
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27251286
109Non-small cell lung cancer_Homo sapiens_hsa052230.26995186
110Legionellosis_Homo sapiens_hsa051340.26270182
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25387794
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24114663
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.23583602
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22869412
115Systemic lupus erythematosus_Homo sapiens_hsa053220.22767221
116Fanconi anemia pathway_Homo sapiens_hsa034600.22518557
117Thyroid cancer_Homo sapiens_hsa052160.22207150
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21107153
119Oocyte meiosis_Homo sapiens_hsa041140.20773684
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20330530
121Pancreatic cancer_Homo sapiens_hsa052120.20317587
122HTLV-I infection_Homo sapiens_hsa051660.19175123
123Basal transcription factors_Homo sapiens_hsa030220.19164023
124Viral myocarditis_Homo sapiens_hsa054160.16833528
125Insulin resistance_Homo sapiens_hsa049310.15652083

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