TUFMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)4.94957499
2positive regulation of osteoblast proliferation (GO:0033690)4.56489618
3erythrocyte development (GO:0048821)4.51692360
4granulocyte differentiation (GO:0030851)4.38221859
5proteasome assembly (GO:0043248)4.31489234
6rRNA modification (GO:0000154)4.29123287
7oxidative phosphorylation (GO:0006119)4.19474359
8viral mRNA export from host cell nucleus (GO:0046784)4.19094666
9DNA deamination (GO:0045006)3.95638630
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91862136
11diterpenoid biosynthetic process (GO:0016102)3.85227312
12terpenoid biosynthetic process (GO:0016114)3.83319998
13negative regulation of bone mineralization (GO:0030502)3.80316269
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.65789423
15DNA topological change (GO:0006265)3.63505232
16centriole replication (GO:0007099)3.59351615
17regulation of translational fidelity (GO:0006450)3.56725308
18tRNA aminoacylation for protein translation (GO:0006418)3.52580869
19regulation of centriole replication (GO:0046599)3.52442614
20negative regulation of transcription regulatory region DNA binding (GO:2000678)3.50551575
21regulation of histone H3-K4 methylation (GO:0051569)3.49114741
22cellular response to thyroid hormone stimulus (GO:0097067)3.46575062
23positive regulation of viral genome replication (GO:0045070)3.45701088
24mitotic nuclear envelope reassembly (GO:0007084)3.45204453
25nuclear envelope reassembly (GO:0031468)3.45204453
26synapsis (GO:0007129)3.44638592
27amino acid activation (GO:0043038)3.41504828
28tRNA aminoacylation (GO:0043039)3.41504828
29platelet formation (GO:0030220)3.40417908
30DNA strand elongation involved in DNA replication (GO:0006271)3.39355258
31cytidine metabolic process (GO:0046087)3.35057852
32cytidine catabolic process (GO:0006216)3.35057852
33cytidine deamination (GO:0009972)3.35057852
34negative regulation of biomineral tissue development (GO:0070168)3.31721240
35DNA replication initiation (GO:0006270)3.31579822
36ribosomal small subunit assembly (GO:0000028)3.26783098
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23161250
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.23161250
39NADH dehydrogenase complex assembly (GO:0010257)3.23161250
40aerobic respiration (GO:0009060)3.22715229
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22691299
42pseudouridine synthesis (GO:0001522)3.21671818
43ribosome biogenesis (GO:0042254)3.21577984
44respiratory electron transport chain (GO:0022904)3.21198036
45DNA strand elongation (GO:0022616)3.20144157
46kinetochore assembly (GO:0051382)3.19897481
47positive regulation of erythrocyte differentiation (GO:0045648)3.19804828
48centriole assembly (GO:0098534)3.19373719
49rRNA methylation (GO:0031167)3.19309652
50tRNA modification (GO:0006400)3.18915688
51electron transport chain (GO:0022900)3.17243125
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16103771
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15286582
54detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.15096608
55negative regulation of fatty acid biosynthetic process (GO:0045717)3.09946807
56tRNA methylation (GO:0030488)3.09198940
57sensory perception of smell (GO:0007608)3.04835547
58maturation of SSU-rRNA (GO:0030490)3.03864155
59kinetochore organization (GO:0051383)3.01343214
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97750511
61mitotic nuclear envelope disassembly (GO:0007077)2.96937592
62positive regulation of ligase activity (GO:0051351)2.96320310
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95905876
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95905876
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94840654
66termination of RNA polymerase I transcription (GO:0006363)2.94226789
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93484660
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93484660
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93484660
70regulation of histone H3-K27 methylation (GO:0061085)2.92832555
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92531090
72negative regulation of ligase activity (GO:0051352)2.92531090
73regulation of cellular amino acid metabolic process (GO:0006521)2.91635175
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91488699
75positive regulation of histone H3-K4 methylation (GO:0051571)2.90498485
76protein complex biogenesis (GO:0070271)2.90048458
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90036290
78CENP-A containing nucleosome assembly (GO:0034080)2.89062362
79regulation of mitochondrial translation (GO:0070129)2.88509918
80protoporphyrinogen IX biosynthetic process (GO:0006782)2.88500923
81energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88432884
82ATP synthesis coupled proton transport (GO:0015986)2.88432884
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87469218
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87469218
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86523763
86signal transduction involved in DNA damage checkpoint (GO:0072422)2.86523763
87protoporphyrinogen IX metabolic process (GO:0046501)2.86019299
88mitochondrial calcium ion transport (GO:0006851)2.84834941
89DNA unwinding involved in DNA replication (GO:0006268)2.84586930
90regulation of ubiquitin-protein transferase activity (GO:0051438)2.84009210
91tetrahydrofolate metabolic process (GO:0046653)2.83746150
92telomere maintenance via semi-conservative replication (GO:0032201)2.83271736
93response to thyroid hormone (GO:0097066)2.83222009
94pyrimidine ribonucleoside catabolic process (GO:0046133)2.83072612
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.81250058
96formation of translation preinitiation complex (GO:0001731)2.80949730
97mitochondrial respiratory chain complex assembly (GO:0033108)2.80035456
98isoprenoid biosynthetic process (GO:0008299)2.78695496
99telomere maintenance via recombination (GO:0000722)2.74958173
100Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73590668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.86849483
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29179963
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55651105
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.48563591
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13622982
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09487857
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.06871769
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.04802443
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98269356
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.81511353
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80404265
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79987438
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75836405
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62410766
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.61095634
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54413001
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.38012074
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33813789
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.28726555
20VDR_23849224_ChIP-Seq_CD4+_Human2.26782710
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26715968
22DCP1A_22483619_ChIP-Seq_HELA_Human2.21650353
23GABP_19822575_ChIP-Seq_HepG2_Human2.21592683
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16801629
25FOXP3_21729870_ChIP-Seq_TREG_Human2.07903555
26XRN2_22483619_ChIP-Seq_HELA_Human2.07302187
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06629171
28NCOR1_26117541_ChIP-Seq_K562_Human2.02231053
29ELK1_19687146_ChIP-ChIP_HELA_Human1.99465736
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95833958
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91921661
32KDM5A_27292631_Chip-Seq_BREAST_Human1.91337300
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82268890
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72035328
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71281972
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70126412
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69586209
38TTF2_22483619_ChIP-Seq_HELA_Human1.68463364
39GATA1_22025678_ChIP-Seq_K562_Human1.66220513
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62407456
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59632199
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58369044
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.57614852
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52958203
45CIITA_25753668_ChIP-Seq_RAJI_Human1.50750619
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45374787
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45346696
48VDR_22108803_ChIP-Seq_LS180_Human1.44170763
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42420433
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.41912482
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40967685
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.40302955
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36731359
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36178909
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.32304557
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32154527
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31055031
58GATA1_19941826_ChIP-Seq_K562_Human1.29098434
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28906669
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26888454
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25488736
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24242635
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22772415
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19270893
65CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14854923
66MAF_26560356_Chip-Seq_TH2_Human1.10875380
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09427938
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08985575
69ZNF263_19887448_ChIP-Seq_K562_Human1.07010460
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.05998982
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04527582
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02633805
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02252533
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00789902
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99983230
76NOTCH1_21737748_ChIP-Seq_TLL_Human0.99105936
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99002154
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.98534941
79SPI1_23547873_ChIP-Seq_NB4_Human0.98148280
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98050052
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97509553
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95558647
83STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94459208
84SPI1_23127762_ChIP-Seq_K562_Human0.93662992
85MYC_18940864_ChIP-ChIP_HL60_Human0.89009443
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88816174
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87631270
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87199728
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86102357
90E2F1_20622854_ChIP-Seq_HELA_Human0.85339398
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84260002
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83695856
93GATA2_19941826_ChIP-Seq_K562_Human0.83575708
94TFEB_21752829_ChIP-Seq_HELA_Human0.83055512
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82752114
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.81947781
97MYB_26560356_Chip-Seq_TH2_Human0.81540837
98STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80615761
99MYB_26560356_Chip-Seq_TH1_Human0.78631780
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.78124153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system4.98956140
2MP0004147_increased_porphyrin_level4.65731801
3MP0008995_early_reproductive_senescence3.67495441
4MP0003111_abnormal_nucleus_morphology3.62977408
5MP0003786_premature_aging3.60620842
6MP0001661_extended_life_span3.04262644
7MP0005360_urolithiasis2.98535837
8MP0010094_abnormal_chromosome_stability2.95028709
9MP0001873_stomach_inflammation2.90237216
10MP0004957_abnormal_blastocyst_morpholog2.81102854
11MP0008058_abnormal_DNA_repair2.74086236
12MP0003693_abnormal_embryo_hatching2.72017561
13MP0006036_abnormal_mitochondrial_physio2.65043314
14MP0001545_abnormal_hematopoietic_system2.54933345
15MP0005397_hematopoietic_system_phenotyp2.54933345
16MP0010307_abnormal_tumor_latency2.41663199
17MP0005083_abnormal_biliary_tract2.26131478
18MP0000678_abnormal_parathyroid_gland2.26023670
19MP0003656_abnormal_erythrocyte_physiolo2.12629034
20MP0008007_abnormal_cellular_replicative1.96596795
21MP0005646_abnormal_pituitary_gland1.94623010
22MP0009333_abnormal_splenocyte_physiolog1.93895206
23MP0008875_abnormal_xenobiotic_pharmacok1.90464191
24MP0008872_abnormal_physiological_respon1.87820279
25MP0001764_abnormal_homeostasis1.87690629
26MP0008932_abnormal_embryonic_tissue1.71820034
27MP0005636_abnormal_mineral_homeostasis1.69493129
28MP0003077_abnormal_cell_cycle1.68073700
29MP0001529_abnormal_vocalization1.64552205
30MP0005671_abnormal_response_to1.60741655
31MP0006035_abnormal_mitochondrial_morpho1.60580429
32MP0008057_abnormal_DNA_replication1.54674282
33MP0003718_maternal_effect1.54079123
34MP0000372_irregular_coat_pigmentation1.52316001
35MP0009697_abnormal_copulation1.37328811
36MP0000313_abnormal_cell_death1.31970692
37MP0000703_abnormal_thymus_morphology1.30572606
38MP0002210_abnormal_sex_determination1.18289922
39MP0001929_abnormal_gametogenesis1.18050354
40MP0002722_abnormal_immune_system1.15390819
41MP0002019_abnormal_tumor_incidence1.15177278
42MP0000358_abnormal_cell_content/1.14236356
43MP0002398_abnormal_bone_marrow1.13440879
44MP0004145_abnormal_muscle_electrophysio1.10561707
45MP0001502_abnormal_circadian_rhythm1.09936521
46MP0001697_abnormal_embryo_size1.04794111
47MP0008770_decreased_survivor_rate0.98314183
48MP0003186_abnormal_redox_activity0.97881461
49MP0001881_abnormal_mammary_gland0.96668657
50MP0005410_abnormal_fertilization0.95302893
51MP0000350_abnormal_cell_proliferation0.92550991
52MP0003646_muscle_fatigue0.88511906
53MP0002080_prenatal_lethality0.87914423
54MP0002429_abnormal_blood_cell0.87807853
55MP0000689_abnormal_spleen_morphology0.87136697
56MP0005365_abnormal_bile_salt0.86665700
57MP0002877_abnormal_melanocyte_morpholog0.85871922
58MP0001853_heart_inflammation0.84793299
59MP0003763_abnormal_thymus_physiology0.84158295
60MP0001145_abnormal_male_reproductive0.83419856
61MP0005584_abnormal_enzyme/coenzyme_acti0.81505687
62MP0003806_abnormal_nucleotide_metabolis0.79141642
63MP0003698_abnormal_male_reproductive0.78701499
64MP0002269_muscular_atrophy0.78437176
65MP0005332_abnormal_amino_acid0.78185664
66MP0001730_embryonic_growth_arrest0.77397808
67MP0000613_abnormal_salivary_gland0.76757011
68MP0000653_abnormal_sex_gland0.76664092
69MP0003137_abnormal_impulse_conducting0.75893737
70MP0000716_abnormal_immune_system0.72781670
71MP0003699_abnormal_female_reproductive0.72553441
72MP0003959_abnormal_lean_body0.71617027
73MP0001119_abnormal_female_reproductive0.69081065
74MP0005451_abnormal_body_composition0.68857948
75MP0001243_abnormal_dermal_layer0.67927882
76MP0000747_muscle_weakness0.67698313
77MP0002160_abnormal_reproductive_system0.67117578
78MP0002095_abnormal_skin_pigmentation0.65611332
79MP0002396_abnormal_hematopoietic_system0.65260163
80MP0001919_abnormal_reproductive_system0.64804984
81MP0004134_abnormal_chest_morphology0.63815035
82MP0001191_abnormal_skin_condition0.63710387
83MP0006072_abnormal_retinal_apoptosis0.62838669
84MP0005389_reproductive_system_phenotype0.61167683
85MP0000598_abnormal_liver_morphology0.61001435
86MP0000609_abnormal_liver_physiology0.59932890
87MP0005171_absent_coat_pigmentation0.59703307
88MP0008877_abnormal_DNA_methylation0.59349366
89MP0009931_abnormal_skin_appearance0.59185040
90MP0009785_altered_susceptibility_to0.59083024
91MP0006292_abnormal_olfactory_placode0.57408540
92MP0004808_abnormal_hematopoietic_stem0.56712077
93MP0002086_abnormal_extraembryonic_tissu0.55935945
94MP0001727_abnormal_embryo_implantation0.55866813
95MP0005380_embryogenesis_phenotype0.55155625
96MP0001672_abnormal_embryogenesis/_devel0.55155625
97MP0002161_abnormal_fertility/fecundity0.55120077
98MP0004947_skin_inflammation0.52486104
99MP0002420_abnormal_adaptive_immunity0.51984849
100MP0001819_abnormal_immune_cell0.50854709

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)5.50404545
2Acute necrotizing encephalopathy (HP:0006965)4.91220986
3Reticulocytosis (HP:0001923)4.82998254
4Acanthocytosis (HP:0001927)4.63982946
5Abnormal mitochondria in muscle tissue (HP:0008316)4.50373747
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.47829432
7Acute encephalopathy (HP:0006846)4.32215075
8Truncus arteriosus (HP:0001660)4.03421387
9Progressive macrocephaly (HP:0004481)3.96425375
10Abnormality of reticulocytes (HP:0004312)3.95205438
11Mitochondrial inheritance (HP:0001427)3.94298449
12Hepatocellular necrosis (HP:0001404)3.93986134
13Polycythemia (HP:0001901)3.93941070
14Hyperthyroidism (HP:0000836)3.88681709
15Abnormal gallbladder physiology (HP:0012438)3.85055386
16Cholecystitis (HP:0001082)3.85055386
17Birth length less than 3rd percentile (HP:0003561)3.82785844
18Increased CSF lactate (HP:0002490)3.73539747
19Aplastic anemia (HP:0001915)3.54775030
20Cerebral edema (HP:0002181)3.51953114
21Hepatic necrosis (HP:0002605)3.42773799
22Poikilocytosis (HP:0004447)3.32167452
23Seborrheic dermatitis (HP:0001051)3.27685555
24Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.16495643
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10212157
26Chromsome breakage (HP:0040012)3.04124974
27Petechiae (HP:0000967)3.02787865
28Abnormality of cochlea (HP:0000375)2.89509091
29Short 5th finger (HP:0009237)2.85249802
30Hypertensive crisis (HP:0100735)2.85083200
31Duodenal stenosis (HP:0100867)2.84409464
32Small intestinal stenosis (HP:0012848)2.84409464
33Brushfield spots (HP:0001088)2.81899898
34Abnormality of DNA repair (HP:0003254)2.80562012
35Type I transferrin isoform profile (HP:0003642)2.79860117
36Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.77368385
37Abnormal number of erythroid precursors (HP:0012131)2.77189188
38Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.76570763
39Breech presentation (HP:0001623)2.76279328
40Entropion (HP:0000621)2.72837487
41Pallor (HP:0000980)2.71468643
42Upper limb muscle weakness (HP:0003484)2.68005905
43Complete atrioventricular canal defect (HP:0001674)2.67939395
44Atelectasis (HP:0100750)2.62309805
45Abnormality of the renal collecting system (HP:0004742)2.60672612
46Hypoparathyroidism (HP:0000829)2.59144315
47Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.58661856
48Duplicated collecting system (HP:0000081)2.58090522
49Abnormality of homocysteine metabolism (HP:0010919)2.54398479
50Homocystinuria (HP:0002156)2.54398479
51Abnormality of dental color (HP:0011073)2.49376735
52Abnormality of the phalanges of the 5th finger (HP:0004213)2.45941863
53Abnormal platelet function (HP:0011869)2.43931690
54Impaired platelet aggregation (HP:0003540)2.43931690
55Overlapping toe (HP:0001845)2.41726214
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39320486
57Abnormal protein N-linked glycosylation (HP:0012347)2.39320486
58Abnormal protein glycosylation (HP:0012346)2.39320486
59Abnormal glycosylation (HP:0012345)2.39320486
60Septate vagina (HP:0001153)2.39242068
61Abnormality of cells of the erythroid lineage (HP:0012130)2.33251137
62Hypoplastic iliac wings (HP:0002866)2.32618315
63Aplasia/Hypoplasia of the earlobes (HP:0009906)2.31656920
64Facial hemangioma (HP:0000329)2.30894908
65Broad palm (HP:0001169)2.29245794
66Optic disc pallor (HP:0000543)2.28561760
67Respiratory failure (HP:0002878)2.27313783
68Abnormality of pyrimidine metabolism (HP:0004353)2.24272317
69Morphological abnormality of the inner ear (HP:0011390)2.20814851
70Increased serum lactate (HP:0002151)2.20409952
71Pancytopenia (HP:0001876)2.20271367
72Abnormality of the tricuspid valve (HP:0001702)2.19770930
73Hypoproteinemia (HP:0003075)2.19708337
74Ileus (HP:0002595)2.18718557
75Abnormality of the duodenum (HP:0002246)2.18103619
76Lactic acidosis (HP:0003128)2.17728857
77Protruding tongue (HP:0010808)2.13147867
78Abnormality of the preputium (HP:0100587)2.10096991
79Reticulocytopenia (HP:0001896)2.09865051
80Poikiloderma (HP:0001029)2.08969500
81Atrioventricular canal defect (HP:0006695)2.07945157
82Macrocytic anemia (HP:0001972)2.04773510
83Oral leukoplakia (HP:0002745)2.03241845
84Horseshoe kidney (HP:0000085)2.02465448
85Obstructive lung disease (HP:0006536)2.02132523
86Chronic obstructive pulmonary disease (HP:0006510)2.02132523
87Aplasia/Hypoplasia of the thymus (HP:0010515)2.01617453
88Increased serum pyruvate (HP:0003542)2.00338584
89Exercise intolerance (HP:0003546)1.99598942
90Leukodystrophy (HP:0002415)1.99429479
91Myelodysplasia (HP:0002863)1.99213606
92Deep palmar crease (HP:0006191)1.98133900
93Severe combined immunodeficiency (HP:0004430)1.96970039
94Nonimmune hydrops fetalis (HP:0001790)1.95975926
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.95833902
96Broad alveolar ridges (HP:0000187)1.95521524
97Abnormality of glycolysis (HP:0004366)1.94877129
98Hypoplasia of the pons (HP:0012110)1.94521596
99Increased hepatocellular lipid droplets (HP:0006565)1.90254797
100Self-mutilation (HP:0000742)1.86869578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.13713713
2PLK43.79118828
3CLK13.33885044
4TXK3.13250602
5RIPK43.07918815
6CDK123.00192114
7BUB12.78407341
8BRSK22.72974838
9EIF2AK12.61992061
10MST42.40851277
11NME12.40341510
12SRPK12.38699675
13CDK82.14817808
14CDC72.14701074
15BMPR22.12089780
16TTK1.86092466
17BRSK11.82584493
18MAP4K21.80147441
19WEE11.67463019
20KDR1.57098919
21WNK41.53780913
22MAP2K31.50707312
23MAP2K61.48742685
24CCNB11.48730427
25CHEK21.44612357
26FLT31.43742521
27ATR1.40474810
28NUAK11.31671393
29NTRK11.22891967
30RAF11.21407576
31ZAK1.19912053
32BCKDK1.14437215
33EEF2K1.13957035
34NEK11.09441729
35NEK21.06270572
36AKT30.97238520
37NTRK30.96763422
38MAPKAPK50.96510478
39TESK20.94078415
40ERN10.91685122
41TSSK60.91032746
42NME20.90631787
43MAP3K20.89561800
44EPHA30.88611765
45SCYL20.88472462
46RPS6KA50.85884884
47CHEK10.84779897
48MATK0.81793801
49PLK10.78868960
50ADRBK20.78834888
51PTK60.76834668
52ALK0.75674627
53MAP3K120.75570242
54AURKB0.72800885
55STK40.71914774
56PBK0.71794692
57MARK30.70902371
58AURKA0.69929773
59EIF2AK30.68416300
60EPHA20.66339303
61CSNK2A20.66285613
62KSR20.65723047
63TNK20.65577788
64ILK0.63542736
65PAK10.63018660
66VRK10.62966308
67IRAK30.62767320
68ATM0.60035923
69CDK40.59991764
70ITK0.59307256
71MAP3K70.58039561
72MYLK0.56914439
73MAP3K80.56439439
74TEC0.56287200
75MAPK120.55763574
76VRK20.55587811
77BTK0.53745549
78CDK20.51257478
79ZAP700.51149580
80MAP2K40.51070335
81INSRR0.50953331
82CDK10.50424439
83JAK20.49120981
84TLK10.47990271
85PRKCI0.46124220
86CSNK2A10.45935016
87BMX0.45429468
88TAOK30.44729843
89JAK30.44408356
90PIK3CG0.41916177
91SYK0.39903937
92IRAK10.39353503
93EPHB10.38646802
94MAPK130.38023346
95MAPK30.36788940
96CDK30.35714387
97PLK20.33967338
98TRPM70.33192469
99PLK30.33148458
100MKNK10.32218218

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.10891462
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.89165653
3One carbon pool by folate_Homo sapiens_hsa006703.54793795
4DNA replication_Homo sapiens_hsa030303.28427428
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26102971
6Homologous recombination_Homo sapiens_hsa034402.86761555
7Mismatch repair_Homo sapiens_hsa034302.70119535
8Oxidative phosphorylation_Homo sapiens_hsa001902.55669717
9Fanconi anemia pathway_Homo sapiens_hsa034602.52720886
10Spliceosome_Homo sapiens_hsa030402.41815642
11Parkinsons disease_Homo sapiens_hsa050122.41813953
12RNA polymerase_Homo sapiens_hsa030202.39563265
13Nucleotide excision repair_Homo sapiens_hsa034202.31059893
14Ribosome_Homo sapiens_hsa030102.22822633
15RNA transport_Homo sapiens_hsa030132.22107840
16Steroid biosynthesis_Homo sapiens_hsa001002.04806567
17Basal transcription factors_Homo sapiens_hsa030222.04803828
18Base excision repair_Homo sapiens_hsa034101.97586450
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.95574964
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79425322
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77892880
22Huntingtons disease_Homo sapiens_hsa050161.69727463
23Primary immunodeficiency_Homo sapiens_hsa053401.66827083
24RNA degradation_Homo sapiens_hsa030181.63087099
25Pyruvate metabolism_Homo sapiens_hsa006201.52708949
26Biosynthesis of amino acids_Homo sapiens_hsa012301.52368695
27Cell cycle_Homo sapiens_hsa041101.51491581
28Olfactory transduction_Homo sapiens_hsa047401.50961479
29Non-homologous end-joining_Homo sapiens_hsa034501.45644590
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41345362
31Protein export_Homo sapiens_hsa030601.37451671
32Selenocompound metabolism_Homo sapiens_hsa004501.23734330
33mRNA surveillance pathway_Homo sapiens_hsa030151.23197716
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23118965
35Butanoate metabolism_Homo sapiens_hsa006501.22624390
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22397277
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20731696
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.16524461
39Pyrimidine metabolism_Homo sapiens_hsa002401.16416312
40Alzheimers disease_Homo sapiens_hsa050101.16362021
41Carbon metabolism_Homo sapiens_hsa012001.13583048
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13481017
43Fructose and mannose metabolism_Homo sapiens_hsa000510.92332773
44Salmonella infection_Homo sapiens_hsa051320.91355333
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89162153
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80166077
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79545062
48Arginine biosynthesis_Homo sapiens_hsa002200.76083120
49N-Glycan biosynthesis_Homo sapiens_hsa005100.74664848
50Purine metabolism_Homo sapiens_hsa002300.74115618
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72390438
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71829489
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70479450
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65564258
55T cell receptor signaling pathway_Homo sapiens_hsa046600.65505378
56Pentose phosphate pathway_Homo sapiens_hsa000300.62777182
57Metabolic pathways_Homo sapiens_hsa011000.60580037
58Glutathione metabolism_Homo sapiens_hsa004800.57832276
59Shigellosis_Homo sapiens_hsa051310.56865465
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56495445
61p53 signaling pathway_Homo sapiens_hsa041150.54424019
62Antigen processing and presentation_Homo sapiens_hsa046120.53832416
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.52477311
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52102074
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51362388
66Fatty acid metabolism_Homo sapiens_hsa012120.50428302
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49221512
68Propanoate metabolism_Homo sapiens_hsa006400.48066393
69Nitrogen metabolism_Homo sapiens_hsa009100.43860918
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42920378
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42790562
72Cardiac muscle contraction_Homo sapiens_hsa042600.41917971
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37910603
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36300576
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36005099
76Oocyte meiosis_Homo sapiens_hsa041140.35821576
77Epstein-Barr virus infection_Homo sapiens_hsa051690.35031388
78Other glycan degradation_Homo sapiens_hsa005110.33625072
79Measles_Homo sapiens_hsa051620.32904334
80Linoleic acid metabolism_Homo sapiens_hsa005910.32735971
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30105056
82VEGF signaling pathway_Homo sapiens_hsa043700.27631642
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.27450940
84HIF-1 signaling pathway_Homo sapiens_hsa040660.25898328
85Fat digestion and absorption_Homo sapiens_hsa049750.23871521
86Viral carcinogenesis_Homo sapiens_hsa052030.22621357
87Graft-versus-host disease_Homo sapiens_hsa053320.22239672
88Hematopoietic cell lineage_Homo sapiens_hsa046400.22053824
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18394423
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.18347409
91Rheumatoid arthritis_Homo sapiens_hsa053230.18259790
92Lysine degradation_Homo sapiens_hsa003100.17682557
93Ether lipid metabolism_Homo sapiens_hsa005650.16834184
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16297692
95ABC transporters_Homo sapiens_hsa020100.15299268
96Retinol metabolism_Homo sapiens_hsa008300.15045732
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.13013605
98Chemical carcinogenesis_Homo sapiens_hsa052040.11347532
99Mineral absorption_Homo sapiens_hsa049780.10311665
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09610336

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