

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication checkpoint (GO:0000076) | 4.94957499 |
| 2 | positive regulation of osteoblast proliferation (GO:0033690) | 4.56489618 |
| 3 | erythrocyte development (GO:0048821) | 4.51692360 |
| 4 | granulocyte differentiation (GO:0030851) | 4.38221859 |
| 5 | proteasome assembly (GO:0043248) | 4.31489234 |
| 6 | rRNA modification (GO:0000154) | 4.29123287 |
| 7 | oxidative phosphorylation (GO:0006119) | 4.19474359 |
| 8 | viral mRNA export from host cell nucleus (GO:0046784) | 4.19094666 |
| 9 | DNA deamination (GO:0045006) | 3.95638630 |
| 10 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.91862136 |
| 11 | diterpenoid biosynthetic process (GO:0016102) | 3.85227312 |
| 12 | terpenoid biosynthetic process (GO:0016114) | 3.83319998 |
| 13 | negative regulation of bone mineralization (GO:0030502) | 3.80316269 |
| 14 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.65789423 |
| 15 | DNA topological change (GO:0006265) | 3.63505232 |
| 16 | centriole replication (GO:0007099) | 3.59351615 |
| 17 | regulation of translational fidelity (GO:0006450) | 3.56725308 |
| 18 | tRNA aminoacylation for protein translation (GO:0006418) | 3.52580869 |
| 19 | regulation of centriole replication (GO:0046599) | 3.52442614 |
| 20 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 3.50551575 |
| 21 | regulation of histone H3-K4 methylation (GO:0051569) | 3.49114741 |
| 22 | cellular response to thyroid hormone stimulus (GO:0097067) | 3.46575062 |
| 23 | positive regulation of viral genome replication (GO:0045070) | 3.45701088 |
| 24 | mitotic nuclear envelope reassembly (GO:0007084) | 3.45204453 |
| 25 | nuclear envelope reassembly (GO:0031468) | 3.45204453 |
| 26 | synapsis (GO:0007129) | 3.44638592 |
| 27 | amino acid activation (GO:0043038) | 3.41504828 |
| 28 | tRNA aminoacylation (GO:0043039) | 3.41504828 |
| 29 | platelet formation (GO:0030220) | 3.40417908 |
| 30 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.39355258 |
| 31 | cytidine metabolic process (GO:0046087) | 3.35057852 |
| 32 | cytidine catabolic process (GO:0006216) | 3.35057852 |
| 33 | cytidine deamination (GO:0009972) | 3.35057852 |
| 34 | negative regulation of biomineral tissue development (GO:0070168) | 3.31721240 |
| 35 | DNA replication initiation (GO:0006270) | 3.31579822 |
| 36 | ribosomal small subunit assembly (GO:0000028) | 3.26783098 |
| 37 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.23161250 |
| 38 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.23161250 |
| 39 | NADH dehydrogenase complex assembly (GO:0010257) | 3.23161250 |
| 40 | aerobic respiration (GO:0009060) | 3.22715229 |
| 41 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.22691299 |
| 42 | pseudouridine synthesis (GO:0001522) | 3.21671818 |
| 43 | ribosome biogenesis (GO:0042254) | 3.21577984 |
| 44 | respiratory electron transport chain (GO:0022904) | 3.21198036 |
| 45 | DNA strand elongation (GO:0022616) | 3.20144157 |
| 46 | kinetochore assembly (GO:0051382) | 3.19897481 |
| 47 | positive regulation of erythrocyte differentiation (GO:0045648) | 3.19804828 |
| 48 | centriole assembly (GO:0098534) | 3.19373719 |
| 49 | rRNA methylation (GO:0031167) | 3.19309652 |
| 50 | tRNA modification (GO:0006400) | 3.18915688 |
| 51 | electron transport chain (GO:0022900) | 3.17243125 |
| 52 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.16103771 |
| 53 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.15286582 |
| 54 | detection of chemical stimulus involved in sensory perception of smell (GO:0050911) | 3.15096608 |
| 55 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.09946807 |
| 56 | tRNA methylation (GO:0030488) | 3.09198940 |
| 57 | sensory perception of smell (GO:0007608) | 3.04835547 |
| 58 | maturation of SSU-rRNA (GO:0030490) | 3.03864155 |
| 59 | kinetochore organization (GO:0051383) | 3.01343214 |
| 60 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.97750511 |
| 61 | mitotic nuclear envelope disassembly (GO:0007077) | 2.96937592 |
| 62 | positive regulation of ligase activity (GO:0051351) | 2.96320310 |
| 63 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.95905876 |
| 64 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.95905876 |
| 65 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.94840654 |
| 66 | termination of RNA polymerase I transcription (GO:0006363) | 2.94226789 |
| 67 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.93484660 |
| 68 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.93484660 |
| 69 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.93484660 |
| 70 | regulation of histone H3-K27 methylation (GO:0061085) | 2.92832555 |
| 71 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.92531090 |
| 72 | negative regulation of ligase activity (GO:0051352) | 2.92531090 |
| 73 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.91635175 |
| 74 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.91488699 |
| 75 | positive regulation of histone H3-K4 methylation (GO:0051571) | 2.90498485 |
| 76 | protein complex biogenesis (GO:0070271) | 2.90048458 |
| 77 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.90036290 |
| 78 | CENP-A containing nucleosome assembly (GO:0034080) | 2.89062362 |
| 79 | regulation of mitochondrial translation (GO:0070129) | 2.88509918 |
| 80 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 2.88500923 |
| 81 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.88432884 |
| 82 | ATP synthesis coupled proton transport (GO:0015986) | 2.88432884 |
| 83 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.87469218 |
| 84 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.87469218 |
| 85 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.86523763 |
| 86 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.86523763 |
| 87 | protoporphyrinogen IX metabolic process (GO:0046501) | 2.86019299 |
| 88 | mitochondrial calcium ion transport (GO:0006851) | 2.84834941 |
| 89 | DNA unwinding involved in DNA replication (GO:0006268) | 2.84586930 |
| 90 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.84009210 |
| 91 | tetrahydrofolate metabolic process (GO:0046653) | 2.83746150 |
| 92 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.83271736 |
| 93 | response to thyroid hormone (GO:0097066) | 2.83222009 |
| 94 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.83072612 |
| 95 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.81250058 |
| 96 | formation of translation preinitiation complex (GO:0001731) | 2.80949730 |
| 97 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.80035456 |
| 98 | isoprenoid biosynthetic process (GO:0008299) | 2.78695496 |
| 99 | telomere maintenance via recombination (GO:0000722) | 2.74958173 |
| 100 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.73590668 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.86849483 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.29179963 |
| 3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.55651105 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.48563591 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.13622982 |
| 6 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.09487857 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.06871769 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.04802443 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.98269356 |
| 10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.81511353 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.80404265 |
| 12 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.79987438 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.75836405 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.62410766 |
| 15 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.61095634 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.54413001 |
| 17 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 2.38012074 |
| 18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.33813789 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.28726555 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.26782710 |
| 21 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.26715968 |
| 22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.21650353 |
| 23 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.21592683 |
| 24 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.16801629 |
| 25 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.07903555 |
| 26 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.07302187 |
| 27 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.06629171 |
| 28 | NCOR1_26117541_ChIP-Seq_K562_Human | 2.02231053 |
| 29 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.99465736 |
| 30 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.95833958 |
| 31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.91921661 |
| 32 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.91337300 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.82268890 |
| 34 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.72035328 |
| 35 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.71281972 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.70126412 |
| 37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.69586209 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.68463364 |
| 39 | GATA1_22025678_ChIP-Seq_K562_Human | 1.66220513 |
| 40 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.62407456 |
| 41 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.59632199 |
| 42 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.58369044 |
| 43 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.57614852 |
| 44 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52958203 |
| 45 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.50750619 |
| 46 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.45374787 |
| 47 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.45346696 |
| 48 | VDR_22108803_ChIP-Seq_LS180_Human | 1.44170763 |
| 49 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.42420433 |
| 50 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.41912482 |
| 51 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.40967685 |
| 52 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.40302955 |
| 53 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.36731359 |
| 54 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.36178909 |
| 55 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.32304557 |
| 56 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.32154527 |
| 57 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31055031 |
| 58 | GATA1_19941826_ChIP-Seq_K562_Human | 1.29098434 |
| 59 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.28906669 |
| 60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.26888454 |
| 61 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.25488736 |
| 62 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.24242635 |
| 63 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.22772415 |
| 64 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.19270893 |
| 65 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.14854923 |
| 66 | MAF_26560356_Chip-Seq_TH2_Human | 1.10875380 |
| 67 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.09427938 |
| 68 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.08985575 |
| 69 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.07010460 |
| 70 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.05998982 |
| 71 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.04527582 |
| 72 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.02633805 |
| 73 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.02252533 |
| 74 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00789902 |
| 75 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99983230 |
| 76 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.99105936 |
| 77 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.99002154 |
| 78 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.98534941 |
| 79 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.98148280 |
| 80 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.98050052 |
| 81 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97509553 |
| 82 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95558647 |
| 83 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.94459208 |
| 84 | SPI1_23127762_ChIP-Seq_K562_Human | 0.93662992 |
| 85 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.89009443 |
| 86 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.88816174 |
| 87 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.87631270 |
| 88 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.87199728 |
| 89 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.86102357 |
| 90 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.85339398 |
| 91 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.84260002 |
| 92 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.83695856 |
| 93 | GATA2_19941826_ChIP-Seq_K562_Human | 0.83575708 |
| 94 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.83055512 |
| 95 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.82752114 |
| 96 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.81947781 |
| 97 | MYB_26560356_Chip-Seq_TH2_Human | 0.81540837 |
| 98 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.80615761 |
| 99 | MYB_26560356_Chip-Seq_TH1_Human | 0.78631780 |
| 100 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.78124153 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002132_abnormal_respiratory_system | 4.98956140 |
| 2 | MP0004147_increased_porphyrin_level | 4.65731801 |
| 3 | MP0008995_early_reproductive_senescence | 3.67495441 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.62977408 |
| 5 | MP0003786_premature_aging | 3.60620842 |
| 6 | MP0001661_extended_life_span | 3.04262644 |
| 7 | MP0005360_urolithiasis | 2.98535837 |
| 8 | MP0010094_abnormal_chromosome_stability | 2.95028709 |
| 9 | MP0001873_stomach_inflammation | 2.90237216 |
| 10 | MP0004957_abnormal_blastocyst_morpholog | 2.81102854 |
| 11 | MP0008058_abnormal_DNA_repair | 2.74086236 |
| 12 | MP0003693_abnormal_embryo_hatching | 2.72017561 |
| 13 | MP0006036_abnormal_mitochondrial_physio | 2.65043314 |
| 14 | MP0001545_abnormal_hematopoietic_system | 2.54933345 |
| 15 | MP0005397_hematopoietic_system_phenotyp | 2.54933345 |
| 16 | MP0010307_abnormal_tumor_latency | 2.41663199 |
| 17 | MP0005083_abnormal_biliary_tract | 2.26131478 |
| 18 | MP0000678_abnormal_parathyroid_gland | 2.26023670 |
| 19 | MP0003656_abnormal_erythrocyte_physiolo | 2.12629034 |
| 20 | MP0008007_abnormal_cellular_replicative | 1.96596795 |
| 21 | MP0005646_abnormal_pituitary_gland | 1.94623010 |
| 22 | MP0009333_abnormal_splenocyte_physiolog | 1.93895206 |
| 23 | MP0008875_abnormal_xenobiotic_pharmacok | 1.90464191 |
| 24 | MP0008872_abnormal_physiological_respon | 1.87820279 |
| 25 | MP0001764_abnormal_homeostasis | 1.87690629 |
| 26 | MP0008932_abnormal_embryonic_tissue | 1.71820034 |
| 27 | MP0005636_abnormal_mineral_homeostasis | 1.69493129 |
| 28 | MP0003077_abnormal_cell_cycle | 1.68073700 |
| 29 | MP0001529_abnormal_vocalization | 1.64552205 |
| 30 | MP0005671_abnormal_response_to | 1.60741655 |
| 31 | MP0006035_abnormal_mitochondrial_morpho | 1.60580429 |
| 32 | MP0008057_abnormal_DNA_replication | 1.54674282 |
| 33 | MP0003718_maternal_effect | 1.54079123 |
| 34 | MP0000372_irregular_coat_pigmentation | 1.52316001 |
| 35 | MP0009697_abnormal_copulation | 1.37328811 |
| 36 | MP0000313_abnormal_cell_death | 1.31970692 |
| 37 | MP0000703_abnormal_thymus_morphology | 1.30572606 |
| 38 | MP0002210_abnormal_sex_determination | 1.18289922 |
| 39 | MP0001929_abnormal_gametogenesis | 1.18050354 |
| 40 | MP0002722_abnormal_immune_system | 1.15390819 |
| 41 | MP0002019_abnormal_tumor_incidence | 1.15177278 |
| 42 | MP0000358_abnormal_cell_content/ | 1.14236356 |
| 43 | MP0002398_abnormal_bone_marrow | 1.13440879 |
| 44 | MP0004145_abnormal_muscle_electrophysio | 1.10561707 |
| 45 | MP0001502_abnormal_circadian_rhythm | 1.09936521 |
| 46 | MP0001697_abnormal_embryo_size | 1.04794111 |
| 47 | MP0008770_decreased_survivor_rate | 0.98314183 |
| 48 | MP0003186_abnormal_redox_activity | 0.97881461 |
| 49 | MP0001881_abnormal_mammary_gland | 0.96668657 |
| 50 | MP0005410_abnormal_fertilization | 0.95302893 |
| 51 | MP0000350_abnormal_cell_proliferation | 0.92550991 |
| 52 | MP0003646_muscle_fatigue | 0.88511906 |
| 53 | MP0002080_prenatal_lethality | 0.87914423 |
| 54 | MP0002429_abnormal_blood_cell | 0.87807853 |
| 55 | MP0000689_abnormal_spleen_morphology | 0.87136697 |
| 56 | MP0005365_abnormal_bile_salt | 0.86665700 |
| 57 | MP0002877_abnormal_melanocyte_morpholog | 0.85871922 |
| 58 | MP0001853_heart_inflammation | 0.84793299 |
| 59 | MP0003763_abnormal_thymus_physiology | 0.84158295 |
| 60 | MP0001145_abnormal_male_reproductive | 0.83419856 |
| 61 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.81505687 |
| 62 | MP0003806_abnormal_nucleotide_metabolis | 0.79141642 |
| 63 | MP0003698_abnormal_male_reproductive | 0.78701499 |
| 64 | MP0002269_muscular_atrophy | 0.78437176 |
| 65 | MP0005332_abnormal_amino_acid | 0.78185664 |
| 66 | MP0001730_embryonic_growth_arrest | 0.77397808 |
| 67 | MP0000613_abnormal_salivary_gland | 0.76757011 |
| 68 | MP0000653_abnormal_sex_gland | 0.76664092 |
| 69 | MP0003137_abnormal_impulse_conducting | 0.75893737 |
| 70 | MP0000716_abnormal_immune_system | 0.72781670 |
| 71 | MP0003699_abnormal_female_reproductive | 0.72553441 |
| 72 | MP0003959_abnormal_lean_body | 0.71617027 |
| 73 | MP0001119_abnormal_female_reproductive | 0.69081065 |
| 74 | MP0005451_abnormal_body_composition | 0.68857948 |
| 75 | MP0001243_abnormal_dermal_layer | 0.67927882 |
| 76 | MP0000747_muscle_weakness | 0.67698313 |
| 77 | MP0002160_abnormal_reproductive_system | 0.67117578 |
| 78 | MP0002095_abnormal_skin_pigmentation | 0.65611332 |
| 79 | MP0002396_abnormal_hematopoietic_system | 0.65260163 |
| 80 | MP0001919_abnormal_reproductive_system | 0.64804984 |
| 81 | MP0004134_abnormal_chest_morphology | 0.63815035 |
| 82 | MP0001191_abnormal_skin_condition | 0.63710387 |
| 83 | MP0006072_abnormal_retinal_apoptosis | 0.62838669 |
| 84 | MP0005389_reproductive_system_phenotype | 0.61167683 |
| 85 | MP0000598_abnormal_liver_morphology | 0.61001435 |
| 86 | MP0000609_abnormal_liver_physiology | 0.59932890 |
| 87 | MP0005171_absent_coat_pigmentation | 0.59703307 |
| 88 | MP0008877_abnormal_DNA_methylation | 0.59349366 |
| 89 | MP0009931_abnormal_skin_appearance | 0.59185040 |
| 90 | MP0009785_altered_susceptibility_to | 0.59083024 |
| 91 | MP0006292_abnormal_olfactory_placode | 0.57408540 |
| 92 | MP0004808_abnormal_hematopoietic_stem | 0.56712077 |
| 93 | MP0002086_abnormal_extraembryonic_tissu | 0.55935945 |
| 94 | MP0001727_abnormal_embryo_implantation | 0.55866813 |
| 95 | MP0005380_embryogenesis_phenotype | 0.55155625 |
| 96 | MP0001672_abnormal_embryogenesis/_devel | 0.55155625 |
| 97 | MP0002161_abnormal_fertility/fecundity | 0.55120077 |
| 98 | MP0004947_skin_inflammation | 0.52486104 |
| 99 | MP0002420_abnormal_adaptive_immunity | 0.51984849 |
| 100 | MP0001819_abnormal_immune_cell | 0.50854709 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Short middle phalanx of the 5th finger (HP:0004220) | 5.50404545 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.91220986 |
| 3 | Reticulocytosis (HP:0001923) | 4.82998254 |
| 4 | Acanthocytosis (HP:0001927) | 4.63982946 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.50373747 |
| 6 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 4.47829432 |
| 7 | Acute encephalopathy (HP:0006846) | 4.32215075 |
| 8 | Truncus arteriosus (HP:0001660) | 4.03421387 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.96425375 |
| 10 | Abnormality of reticulocytes (HP:0004312) | 3.95205438 |
| 11 | Mitochondrial inheritance (HP:0001427) | 3.94298449 |
| 12 | Hepatocellular necrosis (HP:0001404) | 3.93986134 |
| 13 | Polycythemia (HP:0001901) | 3.93941070 |
| 14 | Hyperthyroidism (HP:0000836) | 3.88681709 |
| 15 | Abnormal gallbladder physiology (HP:0012438) | 3.85055386 |
| 16 | Cholecystitis (HP:0001082) | 3.85055386 |
| 17 | Birth length less than 3rd percentile (HP:0003561) | 3.82785844 |
| 18 | Increased CSF lactate (HP:0002490) | 3.73539747 |
| 19 | Aplastic anemia (HP:0001915) | 3.54775030 |
| 20 | Cerebral edema (HP:0002181) | 3.51953114 |
| 21 | Hepatic necrosis (HP:0002605) | 3.42773799 |
| 22 | Poikilocytosis (HP:0004447) | 3.32167452 |
| 23 | Seborrheic dermatitis (HP:0001051) | 3.27685555 |
| 24 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 3.16495643 |
| 25 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.10212157 |
| 26 | Chromsome breakage (HP:0040012) | 3.04124974 |
| 27 | Petechiae (HP:0000967) | 3.02787865 |
| 28 | Abnormality of cochlea (HP:0000375) | 2.89509091 |
| 29 | Short 5th finger (HP:0009237) | 2.85249802 |
| 30 | Hypertensive crisis (HP:0100735) | 2.85083200 |
| 31 | Duodenal stenosis (HP:0100867) | 2.84409464 |
| 32 | Small intestinal stenosis (HP:0012848) | 2.84409464 |
| 33 | Brushfield spots (HP:0001088) | 2.81899898 |
| 34 | Abnormality of DNA repair (HP:0003254) | 2.80562012 |
| 35 | Type I transferrin isoform profile (HP:0003642) | 2.79860117 |
| 36 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.77368385 |
| 37 | Abnormal number of erythroid precursors (HP:0012131) | 2.77189188 |
| 38 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 2.76570763 |
| 39 | Breech presentation (HP:0001623) | 2.76279328 |
| 40 | Entropion (HP:0000621) | 2.72837487 |
| 41 | Pallor (HP:0000980) | 2.71468643 |
| 42 | Upper limb muscle weakness (HP:0003484) | 2.68005905 |
| 43 | Complete atrioventricular canal defect (HP:0001674) | 2.67939395 |
| 44 | Atelectasis (HP:0100750) | 2.62309805 |
| 45 | Abnormality of the renal collecting system (HP:0004742) | 2.60672612 |
| 46 | Hypoparathyroidism (HP:0000829) | 2.59144315 |
| 47 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 2.58661856 |
| 48 | Duplicated collecting system (HP:0000081) | 2.58090522 |
| 49 | Abnormality of homocysteine metabolism (HP:0010919) | 2.54398479 |
| 50 | Homocystinuria (HP:0002156) | 2.54398479 |
| 51 | Abnormality of dental color (HP:0011073) | 2.49376735 |
| 52 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.45941863 |
| 53 | Abnormal platelet function (HP:0011869) | 2.43931690 |
| 54 | Impaired platelet aggregation (HP:0003540) | 2.43931690 |
| 55 | Overlapping toe (HP:0001845) | 2.41726214 |
| 56 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.39320486 |
| 57 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.39320486 |
| 58 | Abnormal protein glycosylation (HP:0012346) | 2.39320486 |
| 59 | Abnormal glycosylation (HP:0012345) | 2.39320486 |
| 60 | Septate vagina (HP:0001153) | 2.39242068 |
| 61 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.33251137 |
| 62 | Hypoplastic iliac wings (HP:0002866) | 2.32618315 |
| 63 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.31656920 |
| 64 | Facial hemangioma (HP:0000329) | 2.30894908 |
| 65 | Broad palm (HP:0001169) | 2.29245794 |
| 66 | Optic disc pallor (HP:0000543) | 2.28561760 |
| 67 | Respiratory failure (HP:0002878) | 2.27313783 |
| 68 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.24272317 |
| 69 | Morphological abnormality of the inner ear (HP:0011390) | 2.20814851 |
| 70 | Increased serum lactate (HP:0002151) | 2.20409952 |
| 71 | Pancytopenia (HP:0001876) | 2.20271367 |
| 72 | Abnormality of the tricuspid valve (HP:0001702) | 2.19770930 |
| 73 | Hypoproteinemia (HP:0003075) | 2.19708337 |
| 74 | Ileus (HP:0002595) | 2.18718557 |
| 75 | Abnormality of the duodenum (HP:0002246) | 2.18103619 |
| 76 | Lactic acidosis (HP:0003128) | 2.17728857 |
| 77 | Protruding tongue (HP:0010808) | 2.13147867 |
| 78 | Abnormality of the preputium (HP:0100587) | 2.10096991 |
| 79 | Reticulocytopenia (HP:0001896) | 2.09865051 |
| 80 | Poikiloderma (HP:0001029) | 2.08969500 |
| 81 | Atrioventricular canal defect (HP:0006695) | 2.07945157 |
| 82 | Macrocytic anemia (HP:0001972) | 2.04773510 |
| 83 | Oral leukoplakia (HP:0002745) | 2.03241845 |
| 84 | Horseshoe kidney (HP:0000085) | 2.02465448 |
| 85 | Obstructive lung disease (HP:0006536) | 2.02132523 |
| 86 | Chronic obstructive pulmonary disease (HP:0006510) | 2.02132523 |
| 87 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.01617453 |
| 88 | Increased serum pyruvate (HP:0003542) | 2.00338584 |
| 89 | Exercise intolerance (HP:0003546) | 1.99598942 |
| 90 | Leukodystrophy (HP:0002415) | 1.99429479 |
| 91 | Myelodysplasia (HP:0002863) | 1.99213606 |
| 92 | Deep palmar crease (HP:0006191) | 1.98133900 |
| 93 | Severe combined immunodeficiency (HP:0004430) | 1.96970039 |
| 94 | Nonimmune hydrops fetalis (HP:0001790) | 1.95975926 |
| 95 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.95833902 |
| 96 | Broad alveolar ridges (HP:0000187) | 1.95521524 |
| 97 | Abnormality of glycolysis (HP:0004366) | 1.94877129 |
| 98 | Hypoplasia of the pons (HP:0012110) | 1.94521596 |
| 99 | Increased hepatocellular lipid droplets (HP:0006565) | 1.90254797 |
| 100 | Self-mutilation (HP:0000742) | 1.86869578 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PDK2 | 4.13713713 |
| 2 | PLK4 | 3.79118828 |
| 3 | CLK1 | 3.33885044 |
| 4 | TXK | 3.13250602 |
| 5 | RIPK4 | 3.07918815 |
| 6 | CDK12 | 3.00192114 |
| 7 | BUB1 | 2.78407341 |
| 8 | BRSK2 | 2.72974838 |
| 9 | EIF2AK1 | 2.61992061 |
| 10 | MST4 | 2.40851277 |
| 11 | NME1 | 2.40341510 |
| 12 | SRPK1 | 2.38699675 |
| 13 | CDK8 | 2.14817808 |
| 14 | CDC7 | 2.14701074 |
| 15 | BMPR2 | 2.12089780 |
| 16 | TTK | 1.86092466 |
| 17 | BRSK1 | 1.82584493 |
| 18 | MAP4K2 | 1.80147441 |
| 19 | WEE1 | 1.67463019 |
| 20 | KDR | 1.57098919 |
| 21 | WNK4 | 1.53780913 |
| 22 | MAP2K3 | 1.50707312 |
| 23 | MAP2K6 | 1.48742685 |
| 24 | CCNB1 | 1.48730427 |
| 25 | CHEK2 | 1.44612357 |
| 26 | FLT3 | 1.43742521 |
| 27 | ATR | 1.40474810 |
| 28 | NUAK1 | 1.31671393 |
| 29 | NTRK1 | 1.22891967 |
| 30 | RAF1 | 1.21407576 |
| 31 | ZAK | 1.19912053 |
| 32 | BCKDK | 1.14437215 |
| 33 | EEF2K | 1.13957035 |
| 34 | NEK1 | 1.09441729 |
| 35 | NEK2 | 1.06270572 |
| 36 | AKT3 | 0.97238520 |
| 37 | NTRK3 | 0.96763422 |
| 38 | MAPKAPK5 | 0.96510478 |
| 39 | TESK2 | 0.94078415 |
| 40 | ERN1 | 0.91685122 |
| 41 | TSSK6 | 0.91032746 |
| 42 | NME2 | 0.90631787 |
| 43 | MAP3K2 | 0.89561800 |
| 44 | EPHA3 | 0.88611765 |
| 45 | SCYL2 | 0.88472462 |
| 46 | RPS6KA5 | 0.85884884 |
| 47 | CHEK1 | 0.84779897 |
| 48 | MATK | 0.81793801 |
| 49 | PLK1 | 0.78868960 |
| 50 | ADRBK2 | 0.78834888 |
| 51 | PTK6 | 0.76834668 |
| 52 | ALK | 0.75674627 |
| 53 | MAP3K12 | 0.75570242 |
| 54 | AURKB | 0.72800885 |
| 55 | STK4 | 0.71914774 |
| 56 | PBK | 0.71794692 |
| 57 | MARK3 | 0.70902371 |
| 58 | AURKA | 0.69929773 |
| 59 | EIF2AK3 | 0.68416300 |
| 60 | EPHA2 | 0.66339303 |
| 61 | CSNK2A2 | 0.66285613 |
| 62 | KSR2 | 0.65723047 |
| 63 | TNK2 | 0.65577788 |
| 64 | ILK | 0.63542736 |
| 65 | PAK1 | 0.63018660 |
| 66 | VRK1 | 0.62966308 |
| 67 | IRAK3 | 0.62767320 |
| 68 | ATM | 0.60035923 |
| 69 | CDK4 | 0.59991764 |
| 70 | ITK | 0.59307256 |
| 71 | MAP3K7 | 0.58039561 |
| 72 | MYLK | 0.56914439 |
| 73 | MAP3K8 | 0.56439439 |
| 74 | TEC | 0.56287200 |
| 75 | MAPK12 | 0.55763574 |
| 76 | VRK2 | 0.55587811 |
| 77 | BTK | 0.53745549 |
| 78 | CDK2 | 0.51257478 |
| 79 | ZAP70 | 0.51149580 |
| 80 | MAP2K4 | 0.51070335 |
| 81 | INSRR | 0.50953331 |
| 82 | CDK1 | 0.50424439 |
| 83 | JAK2 | 0.49120981 |
| 84 | TLK1 | 0.47990271 |
| 85 | PRKCI | 0.46124220 |
| 86 | CSNK2A1 | 0.45935016 |
| 87 | BMX | 0.45429468 |
| 88 | TAOK3 | 0.44729843 |
| 89 | JAK3 | 0.44408356 |
| 90 | PIK3CG | 0.41916177 |
| 91 | SYK | 0.39903937 |
| 92 | IRAK1 | 0.39353503 |
| 93 | EPHB1 | 0.38646802 |
| 94 | MAPK13 | 0.38023346 |
| 95 | MAPK3 | 0.36788940 |
| 96 | CDK3 | 0.35714387 |
| 97 | PLK2 | 0.33967338 |
| 98 | TRPM7 | 0.33192469 |
| 99 | PLK3 | 0.33148458 |
| 100 | MKNK1 | 0.32218218 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.10891462 |
| 2 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 3.89165653 |
| 3 | One carbon pool by folate_Homo sapiens_hsa00670 | 3.54793795 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.28427428 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.26102971 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 2.86761555 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.70119535 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.55669717 |
| 9 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.52720886 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.41815642 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.41813953 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.39563265 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.31059893 |
| 14 | Ribosome_Homo sapiens_hsa03010 | 2.22822633 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 2.22107840 |
| 16 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.04806567 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 2.04803828 |
| 18 | Base excision repair_Homo sapiens_hsa03410 | 1.97586450 |
| 19 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.95574964 |
| 20 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.79425322 |
| 21 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.77892880 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.69727463 |
| 23 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.66827083 |
| 24 | RNA degradation_Homo sapiens_hsa03018 | 1.63087099 |
| 25 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.52708949 |
| 26 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.52368695 |
| 27 | Cell cycle_Homo sapiens_hsa04110 | 1.51491581 |
| 28 | Olfactory transduction_Homo sapiens_hsa04740 | 1.50961479 |
| 29 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.45644590 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.41345362 |
| 31 | Protein export_Homo sapiens_hsa03060 | 1.37451671 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.23734330 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.23197716 |
| 34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.23118965 |
| 35 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.22624390 |
| 36 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.22397277 |
| 37 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.20731696 |
| 38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.16524461 |
| 39 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.16416312 |
| 40 | Alzheimers disease_Homo sapiens_hsa05010 | 1.16362021 |
| 41 | Carbon metabolism_Homo sapiens_hsa01200 | 1.13583048 |
| 42 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.13481017 |
| 43 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.92332773 |
| 44 | Salmonella infection_Homo sapiens_hsa05132 | 0.91355333 |
| 45 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.89162153 |
| 46 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.80166077 |
| 47 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.79545062 |
| 48 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.76083120 |
| 49 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.74664848 |
| 50 | Purine metabolism_Homo sapiens_hsa00230 | 0.74115618 |
| 51 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.72390438 |
| 52 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.71829489 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.70479450 |
| 54 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.65564258 |
| 55 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.65505378 |
| 56 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.62777182 |
| 57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60580037 |
| 58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.57832276 |
| 59 | Shigellosis_Homo sapiens_hsa05131 | 0.56865465 |
| 60 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.56495445 |
| 61 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.54424019 |
| 62 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.53832416 |
| 63 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.52477311 |
| 64 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.52102074 |
| 65 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.51362388 |
| 66 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.50428302 |
| 67 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.49221512 |
| 68 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.48066393 |
| 69 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.43860918 |
| 70 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.42920378 |
| 71 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.42790562 |
| 72 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.41917971 |
| 73 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.37910603 |
| 74 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.36300576 |
| 75 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.36005099 |
| 76 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.35821576 |
| 77 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.35031388 |
| 78 | Other glycan degradation_Homo sapiens_hsa00511 | 0.33625072 |
| 79 | Measles_Homo sapiens_hsa05162 | 0.32904334 |
| 80 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.32735971 |
| 81 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.30105056 |
| 82 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.27631642 |
| 83 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.27450940 |
| 84 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.25898328 |
| 85 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.23871521 |
| 86 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.22621357 |
| 87 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.22239672 |
| 88 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.22053824 |
| 89 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.18394423 |
| 90 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.18347409 |
| 91 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.18259790 |
| 92 | Lysine degradation_Homo sapiens_hsa00310 | 0.17682557 |
| 93 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.16834184 |
| 94 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.16297692 |
| 95 | ABC transporters_Homo sapiens_hsa02010 | 0.15299268 |
| 96 | Retinol metabolism_Homo sapiens_hsa00830 | 0.15045732 |
| 97 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.13013605 |
| 98 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.11347532 |
| 99 | Mineral absorption_Homo sapiens_hsa04978 | 0.10311665 |
| 100 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.09610336 |

