TULP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tubby-like gene family (TULPs). Members of this family have been identified in plants, vertebrates, and invertebrates. TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. The protein encoded by this gene is thought to play a role in the physiology of photoreceptors. Mutations in this gene are associated with recessive juvenile retinitis pigmentosa and Leber congenital amaurosis-15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)9.23750436
2rhodopsin mediated signaling pathway (GO:0016056)9.01935840
3* photoreceptor cell maintenance (GO:0045494)6.98398584
4retinal cone cell development (GO:0046549)6.97987477
5photoreceptor cell differentiation (GO:0046530)6.76872476
6eye photoreceptor cell differentiation (GO:0001754)6.76872476
7* photoreceptor cell development (GO:0042461)6.35192729
8* eye photoreceptor cell development (GO:0042462)6.17752839
9axon ensheathment in central nervous system (GO:0032291)5.51889549
10central nervous system myelination (GO:0022010)5.51889549
11* detection of light stimulus involved in sensory perception (GO:0050962)5.40234801
12* detection of light stimulus involved in visual perception (GO:0050908)5.40234801
13retinal rod cell development (GO:0046548)5.19661091
14* phototransduction (GO:0007602)5.07160659
15presynaptic membrane assembly (GO:0097105)5.02526279
16phototransduction, visible light (GO:0007603)4.96412216
17* detection of light stimulus (GO:0009583)4.91984136
18* detection of visible light (GO:0009584)4.85744983
19GMP metabolic process (GO:0046037)4.82228763
20* visual perception (GO:0007601)4.74455281
21* sensory perception of light stimulus (GO:0050953)4.73058371
22presynaptic membrane organization (GO:0097090)4.50594086
23DNA deamination (GO:0045006)4.39807886
24positive regulation of guanylate cyclase activity (GO:0031284)4.30572767
25cellular response to ATP (GO:0071318)4.27805580
26fatty acid elongation (GO:0030497)4.27702709
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.25048683
28regulation of mitotic spindle checkpoint (GO:1903504)4.25048683
29mannosylation (GO:0097502)3.90840435
30regulation of guanylate cyclase activity (GO:0031282)3.90653034
31negative regulation of response to food (GO:0032096)3.90645056
32negative regulation of appetite (GO:0032099)3.90645056
33protein-chromophore linkage (GO:0018298)3.89220422
34nonmotile primary cilium assembly (GO:0035058)3.82025120
35* retina development in camera-type eye (GO:0060041)3.77261734
36RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.67620768
37* detection of external stimulus (GO:0009581)3.66430276
38positive regulation of vascular permeability (GO:0043117)3.62915252
39retina layer formation (GO:0010842)3.62491129
40* detection of abiotic stimulus (GO:0009582)3.61908034
41regulation of appetite (GO:0032098)3.60636703
42cornea development in camera-type eye (GO:0061303)3.48028278
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46841252
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.42927731
45histone H3-K4 trimethylation (GO:0080182)3.42842745
46negative regulation of neurotransmitter secretion (GO:0046929)3.39156819
47import into cell (GO:0098657)3.36452548
48cellular response to light stimulus (GO:0071482)3.32834257
49reciprocal DNA recombination (GO:0035825)3.32188154
50reciprocal meiotic recombination (GO:0007131)3.32188154
51replication fork processing (GO:0031297)3.29452655
52regulation of feeding behavior (GO:0060259)3.28629293
53long-chain fatty acid biosynthetic process (GO:0042759)3.25990553
54myelination (GO:0042552)3.25491712
55short-term memory (GO:0007614)3.24479455
56cellular ketone body metabolic process (GO:0046950)3.24216465
57axon ensheathment (GO:0008366)3.22631591
58ensheathment of neurons (GO:0007272)3.22631591
59peptidyl-histidine modification (GO:0018202)3.22166671
60L-fucose catabolic process (GO:0042355)3.22111092
61fucose catabolic process (GO:0019317)3.22111092
62L-fucose metabolic process (GO:0042354)3.22111092
63response to pheromone (GO:0019236)3.15698085
64positive regulation of protein homodimerization activity (GO:0090073)3.13747957
65platelet dense granule organization (GO:0060155)3.13736774
66pseudouridine synthesis (GO:0001522)3.09844331
67negative regulation of neurotransmitter transport (GO:0051589)3.09586047
68DNA strand renaturation (GO:0000733)3.08892111
69negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.08391613
70negative regulation of digestive system process (GO:0060457)3.08256923
71L-amino acid import (GO:0043092)3.05583164
72rRNA catabolic process (GO:0016075)3.03809381
73metallo-sulfur cluster assembly (GO:0031163)3.01203891
74iron-sulfur cluster assembly (GO:0016226)3.01203891
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00142602
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99499841
77postsynaptic membrane organization (GO:0001941)2.98159625
78neuron remodeling (GO:0016322)2.97409162
79indolalkylamine metabolic process (GO:0006586)2.96888320
80regulation of cGMP metabolic process (GO:0030823)2.93750576
81ketone body metabolic process (GO:1902224)2.93088695
82protein localization to synapse (GO:0035418)2.93017627
83negative regulation of thymocyte apoptotic process (GO:0070244)2.91867035
84cell fate commitment involved in formation of primary germ layer (GO:0060795)2.91525231
85regulation of spindle checkpoint (GO:0090231)2.91046891
86drinking behavior (GO:0042756)2.90665083
87cell morphogenesis involved in neuron differentiation (GO:0048667)2.89349937
88response to redox state (GO:0051775)2.89240804
89protein heterotetramerization (GO:0051290)2.88747043
90neuron cell-cell adhesion (GO:0007158)2.88513539
91regulation of voltage-gated calcium channel activity (GO:1901385)2.87195908
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86865881
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.86865881
94regulation of translation, ncRNA-mediated (GO:0045974)2.86865881
95tryptophan catabolic process (GO:0006569)2.85608894
96indole-containing compound catabolic process (GO:0042436)2.85608894
97indolalkylamine catabolic process (GO:0046218)2.85608894
98oligodendrocyte differentiation (GO:0048709)2.84494468
99startle response (GO:0001964)2.83403755
100nucleotide transmembrane transport (GO:1901679)2.82825038
101aldehyde catabolic process (GO:0046185)2.82499479
102positive regulation of histone H3-K4 methylation (GO:0051571)2.81538819
103meiotic chromosome segregation (GO:0045132)2.81212177
104estrogen biosynthetic process (GO:0006703)2.80697121
105mitochondrial RNA metabolic process (GO:0000959)2.80455413
106regulation of response to food (GO:0032095)2.78010276
107tryptophan metabolic process (GO:0006568)2.77967635
108regulation of hexokinase activity (GO:1903299)2.75960837
109regulation of glucokinase activity (GO:0033131)2.75960837
110limb bud formation (GO:0060174)2.74336324
111response to interferon-beta (GO:0035456)2.72594706
112histone mRNA catabolic process (GO:0071044)2.72047275
113regulation of catecholamine metabolic process (GO:0042069)2.71804504
114regulation of dopamine metabolic process (GO:0042053)2.71804504
115protein polyglutamylation (GO:0018095)2.71501704
116behavioral response to nicotine (GO:0035095)2.70580238
117* sensory perception (GO:0007600)2.69852269
118regulation of mesoderm development (GO:2000380)2.67074354
119peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.66726613
120GPI anchor biosynthetic process (GO:0006506)2.66672534
121ncRNA catabolic process (GO:0034661)2.66315727
122purinergic nucleotide receptor signaling pathway (GO:0035590)2.64608637
123preassembly of GPI anchor in ER membrane (GO:0016254)2.64598040
124positive regulation of defense response to virus by host (GO:0002230)2.63871615
125transcription from RNA polymerase III promoter (GO:0006383)2.63183953
126positive regulation of calcium ion import (GO:0090280)2.62924885
127membrane hyperpolarization (GO:0060081)2.61844183
128negative regulation of protein localization to cell surface (GO:2000009)2.61174920
129neural tube formation (GO:0001841)2.60590275
130carnitine transmembrane transport (GO:1902603)2.59560617
131positive regulation of cGMP biosynthetic process (GO:0030828)2.59084894
132double-strand break repair via homologous recombination (GO:0000724)2.58531231
133righting reflex (GO:0060013)2.58227734
134recombinational repair (GO:0000725)2.58205564
135apical protein localization (GO:0045176)2.58187644
136protein K11-linked deubiquitination (GO:0035871)2.58056818
137organic cation transport (GO:0015695)2.58024907
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.57967154
139multicellular organism reproduction (GO:0032504)2.56743629
140amino-acid betaine transport (GO:0015838)2.56511388
141carnitine transport (GO:0015879)2.56511388
142GPI anchor metabolic process (GO:0006505)2.56006992
143negative regulation of multicellular organism growth (GO:0040015)2.54328756
144regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.52556966
145appendage development (GO:0048736)2.52501039
146limb development (GO:0060173)2.52501039
147positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52492790
148respiratory chain complex IV assembly (GO:0008535)2.50598126
149positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.49698676
150regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.49698676
151negative regulation of response to nutrient levels (GO:0032108)2.48224947
152negative regulation of response to extracellular stimulus (GO:0032105)2.48224947
153positive regulation of action potential (GO:0045760)2.47857841
154cerebral cortex radially oriented cell migration (GO:0021799)2.46373343
155regulation of cGMP biosynthetic process (GO:0030826)2.44216606
156spinal cord motor neuron differentiation (GO:0021522)2.44084118
157auditory receptor cell stereocilium organization (GO:0060088)2.43598490
158cranial nerve structural organization (GO:0021604)2.43413493
159positive regulation of protein sumoylation (GO:0033235)2.43389800
160mannose metabolic process (GO:0006013)2.43199997
161interleukin-6-mediated signaling pathway (GO:0070102)2.42696588
162membrane assembly (GO:0071709)2.41179782
163cytidine metabolic process (GO:0046087)2.39813718
164cytidine catabolic process (GO:0006216)2.39813718
165cytidine deamination (GO:0009972)2.39813718
166regulation of posttranscriptional gene silencing (GO:0060147)2.38696240
167regulation of gene silencing by miRNA (GO:0060964)2.38696240
168regulation of gene silencing by RNA (GO:0060966)2.38696240
169positive regulation of oligodendrocyte differentiation (GO:0048714)2.37728153
170negative regulation of DNA-dependent DNA replication (GO:2000104)2.37555629
171kynurenine metabolic process (GO:0070189)2.37543393
172* neuron development (GO:0048666)2.37293397
173negative regulation of transcription regulatory region DNA binding (GO:2000678)2.37130353
174magnesium ion transport (GO:0015693)2.35888696
175regulation of somitogenesis (GO:0014807)2.34148112
176regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.32369339
177positive regulation of cGMP metabolic process (GO:0030825)2.32365713
178peptidyl-tyrosine autophosphorylation (GO:0038083)2.31861016
179amino acid import (GO:0043090)2.30764809
180Golgi to plasma membrane protein transport (GO:0043001)2.30617439
181water-soluble vitamin biosynthetic process (GO:0042364)2.30511005
182axoneme assembly (GO:0035082)2.29816120
183response to epinephrine (GO:0071871)2.29455609
184establishment of mitochondrion localization (GO:0051654)2.29403552
185negative regulation of synaptic transmission, GABAergic (GO:0032229)2.27919878
186adult walking behavior (GO:0007628)2.27287213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.96185985
2GBX2_23144817_ChIP-Seq_PC3_Human3.77217618
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.58085411
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07608339
5ZNF274_21170338_ChIP-Seq_K562_Hela2.90800559
6EZH2_22144423_ChIP-Seq_EOC_Human2.88907275
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.80854974
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.62101852
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25319753
10EWS_26573619_Chip-Seq_HEK293_Human2.21039513
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19702291
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17457924
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12219816
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09517892
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.05583846
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04991252
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03803076
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01707420
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01675211
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.99945176
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.95792130
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88533716
23VDR_22108803_ChIP-Seq_LS180_Human1.87790065
24* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86729813
25* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86729813
26TAF15_26573619_Chip-Seq_HEK293_Human1.85705520
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85324597
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85046743
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81637224
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79113888
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.78361778
32TP53_22573176_ChIP-Seq_HFKS_Human1.78286502
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77918559
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.75376558
35* EZH2_27294783_Chip-Seq_ESCs_Mouse1.74730157
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74341856
37* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73801529
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71994915
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71384053
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70769115
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69826377
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69467988
43* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69458371
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68315025
45CBP_20019798_ChIP-Seq_JUKART_Human1.68315025
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66403678
47BCAT_22108803_ChIP-Seq_LS180_Human1.66376599
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64626706
49* RNF2_27304074_Chip-Seq_ESCs_Mouse1.63461666
50* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62513425
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62219093
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61112991
53P300_19829295_ChIP-Seq_ESCs_Human1.60788525
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60751219
55ER_23166858_ChIP-Seq_MCF-7_Human1.59765477
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.59567898
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.59229223
58DROSHA_22980978_ChIP-Seq_HELA_Human1.58368859
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57485707
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55687644
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.55061076
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.55061076
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54249543
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54167449
65MYC_18940864_ChIP-ChIP_HL60_Human1.53106920
66VDR_23849224_ChIP-Seq_CD4+_Human1.50728302
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.48114535
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47976299
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46945083
70AR_21572438_ChIP-Seq_LNCaP_Human1.46878343
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.46595384
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46415265
73SMAD4_21799915_ChIP-Seq_A2780_Human1.46352828
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44991239
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42344712
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.41726488
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.41675432
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40106189
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.39194271
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.36554851
81P300_18555785_Chip-Seq_ESCs_Mouse1.34769581
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.34255528
83FUS_26573619_Chip-Seq_HEK293_Human1.34170151
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33966553
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33227852
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32249780
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32200597
88P53_22387025_ChIP-Seq_ESCs_Mouse1.31954763
89RNF2_27304074_Chip-Seq_NSC_Mouse1.31463499
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30526652
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29487491
92* WDR5_24793694_ChIP-Seq_LNCAP_Human1.28371289
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26694045
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.26534988
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26407353
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.26173292
97STAT3_23295773_ChIP-Seq_U87_Human1.24963035
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24535921
99AR_20517297_ChIP-Seq_VCAP_Human1.22935309
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22546886
101FOXP3_21729870_ChIP-Seq_TREG_Human1.22442450
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21727650
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.21721574
104HOXB7_26014856_ChIP-Seq_BT474_Human1.21578935
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.21107804
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.20816128
107TCF4_22108803_ChIP-Seq_LS180_Human1.20707700
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19783160
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19557122
110NFYB_21822215_ChIP-Seq_K562_Human1.19500363
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19362240
112ELK1_19687146_ChIP-ChIP_HELA_Human1.18769979
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18767944
114NANOG_19829295_ChIP-Seq_ESCs_Human1.18602993
115SOX2_19829295_ChIP-Seq_ESCs_Human1.18602993
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17779728
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17779728
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16973801
119ETV1_20927104_ChIP-Seq_GIST48_Human1.16337050
120NMYC_18555785_Chip-Seq_ESCs_Mouse1.15943605
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15628270
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14963997
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.14033016
124SCL_19346495_ChIP-Seq_HPC-7_Human1.13743103
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13227616
126* NCOR_22424771_ChIP-Seq_293T_Human1.13202703
127PHF8_20622853_ChIP-Seq_HELA_Human1.13111737
128GATA1_22025678_ChIP-Seq_K562_Human1.12822090
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.12389091
130HNFA_21074721_ChIP-Seq_CACO-2_Human1.12281521
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12206006
132EST1_17652178_ChIP-ChIP_JURKAT_Human1.12034982
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12017661
134REST_21632747_ChIP-Seq_MESCs_Mouse1.11097238
135TCF4_23295773_ChIP-Seq_U87_Human1.10759664
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.10445517
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09652774
138CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09335691
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09314255
140RBPJ_21746931_ChIP-Seq_IB4_Human1.08756257
141IGF1R_20145208_ChIP-Seq_DFB_Human1.08572262
142ZFX_18555785_Chip-Seq_ESCs_Mouse1.08364091
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07994294
144CTCF_18555785_Chip-Seq_ESCs_Mouse1.07324315
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.06929634
146GATA3_26560356_Chip-Seq_TH2_Human1.06891847
147ARNT_22903824_ChIP-Seq_MCF-7_Human1.06863735
148CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06806358
149CDX2_22108803_ChIP-Seq_LS180_Human1.06513310
150NFYA_21822215_ChIP-Seq_K562_Human1.06481320
151SMAD3_21741376_ChIP-Seq_HESCs_Human1.05822106
152JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05721978
153GATA6_21074721_ChIP-Seq_CACO-2_Human1.04666044
154RUNX2_22187159_ChIP-Seq_PCA_Human1.04412181
155PU1_27457419_Chip-Seq_LIVER_Mouse1.03954256
156SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03827735
157TBL1_22424771_ChIP-Seq_293T_Human1.03572252
158SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03253577
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02845307
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02502560
161POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02053595
162SMAD4_21741376_ChIP-Seq_EPCs_Human1.01961114
163TAF2_19829295_ChIP-Seq_ESCs_Human1.01771165
164TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00153580
165GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00003176
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99640784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog6.38544999
2MP0003011_delayed_dark_adaptation5.86658306
3MP0003950_abnormal_plasma_membrane4.32432588
4* MP0005253_abnormal_eye_physiology4.24953114
5* MP0006072_abnormal_retinal_apoptosis3.90587533
6MP0005409_darkened_coat_color3.33642180
7MP0003880_abnormal_central_pattern3.18141602
8MP0003136_yellow_coat_color2.97678239
9* MP0005195_abnormal_posterior_eye2.79626394
10MP0006292_abnormal_olfactory_placode2.67255413
11MP0008877_abnormal_DNA_methylation2.62152025
12MP0009697_abnormal_copulation2.50491367
13MP0005423_abnormal_somatic_nervous2.49143381
14MP0002638_abnormal_pupillary_reflex2.29390872
15MP0002396_abnormal_hematopoietic_system2.19982024
16* MP0002229_neurodegeneration2.18062838
17* MP0001324_abnormal_eye_pigmentation2.11900776
18MP0001986_abnormal_taste_sensitivity2.11831669
19MP0001486_abnormal_startle_reflex2.11390575
20* MP0005391_vision/eye_phenotype2.04457241
21MP0000920_abnormal_myelination2.00523876
22MP0008057_abnormal_DNA_replication1.98575062
23MP0003693_abnormal_embryo_hatching1.96272085
24MP0001188_hyperpigmentation1.91436035
25* MP0002752_abnormal_somatic_nervous1.87875087
26MP0004742_abnormal_vestibular_system1.84799395
27MP0004381_abnormal_hair_follicle1.82427055
28MP0008872_abnormal_physiological_respon1.80157077
29MP0005171_absent_coat_pigmentation1.79075150
30MP0004270_analgesia1.74788515
31MP0004142_abnormal_muscle_tone1.72421905
32MP0004885_abnormal_endolymph1.68285596
33MP0002876_abnormal_thyroid_physiology1.65494220
34MP0002736_abnormal_nociception_after1.64416647
35MP0008007_abnormal_cellular_replicative1.62277298
36MP0002272_abnormal_nervous_system1.61213117
37MP0009780_abnormal_chondrocyte_physiolo1.61128665
38MP0000013_abnormal_adipose_tissue1.57082788
39MP0002234_abnormal_pharynx_morphology1.55513527
40MP0001835_abnormal_antigen_presentation1.55381238
41MP0001529_abnormal_vocalization1.51984820
42MP0002822_catalepsy1.50479716
43MP0001502_abnormal_circadian_rhythm1.46984403
44MP0000778_abnormal_nervous_system1.45942062
45MP0005671_abnormal_response_to1.45309799
46* MP0002882_abnormal_neuron_morphology1.42923783
47MP0003315_abnormal_perineum_morphology1.40788584
48MP0002090_abnormal_vision1.39050561
49MP0000566_synostosis1.36343846
50MP0004133_heterotaxia1.36247357
51MP0004145_abnormal_muscle_electrophysio1.36093234
52MP0010094_abnormal_chromosome_stability1.35200212
53MP0003195_calcinosis1.33818898
54MP0002102_abnormal_ear_morphology1.33452699
55MP0008875_abnormal_xenobiotic_pharmacok1.33300762
56MP0008058_abnormal_DNA_repair1.32997031
57MP0001963_abnormal_hearing_physiology1.32693323
58MP0001873_stomach_inflammation1.30948991
59MP0002064_seizures1.30207050
60MP0001905_abnormal_dopamine_level1.28695617
61MP0002254_reproductive_system_inflammat1.28129549
62MP0002837_dystrophic_cardiac_calcinosis1.26947162
63MP0005174_abnormal_tail_pigmentation1.22415916
64MP0005389_reproductive_system_phenotype1.22413485
65MP0000462_abnormal_digestive_system1.20380010
66MP0004147_increased_porphyrin_level1.17518986
67MP0003878_abnormal_ear_physiology1.16748622
68MP0005377_hearing/vestibular/ear_phenot1.16748622
69MP0001485_abnormal_pinna_reflex1.16710048
70MP0003252_abnormal_bile_duct1.15953620
71MP0002734_abnormal_mechanical_nocicepti1.15648904
72MP0003718_maternal_effect1.15090576
73MP0003634_abnormal_glial_cell1.14699614
74MP0009745_abnormal_behavioral_response1.14594791
75MP0001919_abnormal_reproductive_system1.14014656
76MP0009046_muscle_twitch1.11452037
77MP0000026_abnormal_inner_ear1.10427206
78MP0002067_abnormal_sensory_capabilities1.08231734
79MP0003646_muscle_fatigue1.06883469
80MP0001984_abnormal_olfaction1.06863277
81MP0000427_abnormal_hair_cycle1.02816234
82MP0003943_abnormal_hepatobiliary_system1.02412819
83MP0000631_abnormal_neuroendocrine_gland1.01143755
84MP0003567_abnormal_fetal_cardiomyocyte1.00783082
85MP0001440_abnormal_grooming_behavior0.98704920
86MP0003635_abnormal_synaptic_transmissio0.98493018
87MP0010678_abnormal_skin_adnexa0.95622944
88MP0005647_abnormal_sex_gland0.94916006
89MP0000372_irregular_coat_pigmentation0.93903232
90MP0003938_abnormal_ear_development0.93628029
91MP0000015_abnormal_ear_pigmentation0.91057825
92MP0004808_abnormal_hematopoietic_stem0.88741316
93MP0005499_abnormal_olfactory_system0.87839633
94MP0005394_taste/olfaction_phenotype0.87839633
95MP0006276_abnormal_autonomic_nervous0.87787927
96MP0005646_abnormal_pituitary_gland0.87312196
97MP0002572_abnormal_emotion/affect_behav0.86717688
98MP0001501_abnormal_sleep_pattern0.86305709
99MP0001764_abnormal_homeostasis0.86276548
100MP0008789_abnormal_olfactory_epithelium0.85847373
101MP0003638_abnormal_response/metabolism_0.83848555
102MP0005075_abnormal_melanosome_morpholog0.83728154
103MP0005257_abnormal_intraocular_pressure0.82901436
104MP0005410_abnormal_fertilization0.82464515
105MP0001929_abnormal_gametogenesis0.82038722
106MP0003045_fibrosis0.80994827
107MP0003698_abnormal_male_reproductive0.80093650
108MP0002557_abnormal_social/conspecific_i0.79785030
109MP0004924_abnormal_behavior0.79722894
110MP0005386_behavior/neurological_phenoty0.79722894
111MP0003690_abnormal_glial_cell0.79260813
112MP0003937_abnormal_limbs/digits/tail_de0.79049828
113MP0001177_atelectasis0.74728272
114MP0008775_abnormal_heart_ventricle0.74049136
115MP0001661_extended_life_span0.73974465
116MP0005367_renal/urinary_system_phenotyp0.73474370
117MP0000516_abnormal_urinary_system0.73474370
118MP0002653_abnormal_ependyma_morphology0.73154399
119MP0004019_abnormal_vitamin_homeostasis0.72945415
120MP0005645_abnormal_hypothalamus_physiol0.72877579
121MP0003385_abnormal_body_wall0.72700910
122MP0003186_abnormal_redox_activity0.72567056
123MP0003787_abnormal_imprinting0.72499562
124MP0004859_abnormal_synaptic_plasticity0.72083078
125MP0001346_abnormal_lacrimal_gland0.71897618
126MP0001968_abnormal_touch/_nociception0.71794754
127MP0004043_abnormal_pH_regulation0.71708281
128MP0010386_abnormal_urinary_bladder0.70278479
129MP0002163_abnormal_gland_morphology0.69806288
130MP0000049_abnormal_middle_ear0.69168113
131MP0001119_abnormal_female_reproductive0.68711591
132MP0001970_abnormal_pain_threshold0.68686851
133MP0002160_abnormal_reproductive_system0.68524293
134MP0002277_abnormal_respiratory_mucosa0.67241051
135MP0000653_abnormal_sex_gland0.67217505
136MP0008569_lethality_at_weaning0.66717491
137MP0000678_abnormal_parathyroid_gland0.66185961
138MP0002009_preneoplasia0.65617867
139MP0005197_abnormal_uvea_morphology0.65300764
140MP0003786_premature_aging0.65169059
141MP0002184_abnormal_innervation0.65080030
142MP0005332_abnormal_amino_acid0.64924014
143MP0000470_abnormal_stomach_morphology0.64632089
144MP0009250_abnormal_appendicular_skeleto0.63095108
145MP0004084_abnormal_cardiac_muscle0.62589770
146MP0001286_abnormal_eye_development0.62483328
147MP0009643_abnormal_urine_homeostasis0.62003973
148MP0002066_abnormal_motor_capabilities/c0.61766859
149MP0006036_abnormal_mitochondrial_physio0.61478433
150MP0002166_altered_tumor_susceptibility0.61391567
151MP0002063_abnormal_learning/memory/cond0.59512750
152MP0002751_abnormal_autonomic_nervous0.59472164
153MP0000383_abnormal_hair_follicle0.56902692
154MP0005379_endocrine/exocrine_gland_phen0.56594684
155MP0002938_white_spotting0.55797768
156MP0002735_abnormal_chemical_nociception0.55256552

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.68634096
2Absent rod-and cone-mediated responses on ERG (HP:0007688)8.16426008
3Bony spicule pigmentary retinopathy (HP:0007737)7.80694028
4Abnormal rod and cone electroretinograms (HP:0008323)7.70382846
5Chorioretinal atrophy (HP:0000533)6.34693794
6Pigmentary retinal degeneration (HP:0001146)5.89302256
7Abnormality of macular pigmentation (HP:0008002)5.80356744
8Attenuation of retinal blood vessels (HP:0007843)5.69938805
9Abolished electroretinogram (ERG) (HP:0000550)5.69651339
10Decreased central vision (HP:0007663)5.63298564
11Pendular nystagmus (HP:0012043)5.54550525
12Dyschromatopsia (HP:0007641)5.52850468
13Central scotoma (HP:0000603)5.29412976
14Increased corneal curvature (HP:0100692)4.84758366
15Keratoconus (HP:0000563)4.84758366
16Cone-rod dystrophy (HP:0000548)4.82125751
17Scotoma (HP:0000575)4.58131279
18* Photophobia (HP:0000613)4.09935524
19Severe visual impairment (HP:0001141)3.97683857
20Macular degeneration (HP:0000608)3.66047580
21* Type II diabetes mellitus (HP:0005978)3.64673916
22Congenital sensorineural hearing impairment (HP:0008527)3.62781763
23* Retinitis pigmentosa (HP:0000510)3.43514573
24Vitreoretinal degeneration (HP:0000655)3.19939877
25Intestinal atresia (HP:0011100)3.06300823
26Abnormality of the phalanges of the 2nd finger (HP:0009541)3.05563649
27Choroideremia (HP:0001139)2.87879630
28Constricted visual fields (HP:0001133)2.82854213
29Supernumerary spleens (HP:0009799)2.79350388
30Thyroiditis (HP:0100646)2.76150540
31Progressive visual loss (HP:0000529)2.70896432
32Dry hair (HP:0011359)2.69772104
33Parakeratosis (HP:0001036)2.65023400
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.55066199
35Molar tooth sign on MRI (HP:0002419)2.54975108
36Abnormality of midbrain morphology (HP:0002418)2.54975108
37Abnormality of the renal cortex (HP:0011035)2.53955362
38* Optic disc pallor (HP:0000543)2.52581294
39Medial flaring of the eyebrow (HP:0010747)2.51174138
40Renal cortical cysts (HP:0000803)2.50986654
41Asplenia (HP:0001746)2.50614566
42Subcapsular cataract (HP:0000523)2.46572552
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.43836642
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43836642
45Gait imbalance (HP:0002141)2.40543451
46Renal Fanconi syndrome (HP:0001994)2.38973868
47Type II lissencephaly (HP:0007260)2.38769499
48Abnormality of B cell number (HP:0010975)2.37108916
49Congenital primary aphakia (HP:0007707)2.35301417
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32164726
51Nephronophthisis (HP:0000090)2.31773129
52Abnormal drinking behavior (HP:0030082)2.30910952
53Polydipsia (HP:0001959)2.30910952
54Tubulointerstitial nephritis (HP:0001970)2.30889951
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30265370
56Generalized aminoaciduria (HP:0002909)2.27431202
57Prostate neoplasm (HP:0100787)2.26044042
58True hermaphroditism (HP:0010459)2.25983413
59IgG deficiency (HP:0004315)2.23961472
60Methylmalonic acidemia (HP:0002912)2.23600675
61Severe combined immunodeficiency (HP:0004430)2.22542937
62Nephrogenic diabetes insipidus (HP:0009806)2.19479017
63Panhypogammaglobulinemia (HP:0003139)2.19096025
64Increased IgM level (HP:0003496)2.18502118
65Hypophosphatemic rickets (HP:0004912)2.17200559
66Posterior subcapsular cataract (HP:0007787)2.13655903
67Depressed nasal tip (HP:0000437)2.13025485
68Septo-optic dysplasia (HP:0100842)2.10248361
69Aplasia/Hypoplasia involving the musculature (HP:0001460)2.07894803
70Congenital hepatic fibrosis (HP:0002612)2.07302517
71Failure to thrive in infancy (HP:0001531)2.06627455
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.05361322
73Vaginal atresia (HP:0000148)2.04275589
74Autoimmune thrombocytopenia (HP:0001973)2.03714446
75Stomatitis (HP:0010280)1.99982507
76Pancreatic fibrosis (HP:0100732)1.99470283
77Genital tract atresia (HP:0001827)1.97504716
78B lymphocytopenia (HP:0010976)1.96062152
79Median cleft lip (HP:0000161)1.90920519
80Carpal bone hypoplasia (HP:0001498)1.90727585
81Abnormality of the renal collecting system (HP:0004742)1.90360286
82Absent septum pellucidum (HP:0001331)1.89876149
83Peripheral hypomyelination (HP:0007182)1.89875507
84Metabolic alkalosis (HP:0200114)1.89511102
85Aplasia/Hypoplasia of the lens (HP:0008063)1.89242590
86Progressive inability to walk (HP:0002505)1.88521080
87Postaxial foot polydactyly (HP:0001830)1.86675925
88Mitochondrial inheritance (HP:0001427)1.86608914
89Aplasia/Hypoplasia of the tibia (HP:0005772)1.86273296
90Short tibia (HP:0005736)1.85546461
91Fair hair (HP:0002286)1.85081035
92Abnormality of the prostate (HP:0008775)1.84222769
93Chromsome breakage (HP:0040012)1.83562692
94Polyuria (HP:0000103)1.83107210
95Chronic hepatic failure (HP:0100626)1.81707760
96Abnormality of eosinophils (HP:0001879)1.80893309
97Aplasia/Hypoplasia of the fovea (HP:0008060)1.80292119
98Hypoplasia of the fovea (HP:0007750)1.80292119
99Chronic mucocutaneous candidiasis (HP:0002728)1.79699349
100Recurrent cutaneous fungal infections (HP:0011370)1.79699349
101Abnormality of homocysteine metabolism (HP:0010919)1.79678060
102Homocystinuria (HP:0002156)1.79678060
103Stomach cancer (HP:0012126)1.79108183
104Increased CSF lactate (HP:0002490)1.78759671
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.78091307
106Absent/shortened dynein arms (HP:0200106)1.78091307
107Abnormality of T cell physiology (HP:0011840)1.78022582
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77487855
109Abnormality of alanine metabolism (HP:0010916)1.77487855
110Hyperalaninemia (HP:0003348)1.77487855
111Pancreatic cysts (HP:0001737)1.77329809
112Poor coordination (HP:0002370)1.76807557
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.74965692
114Sclerocornea (HP:0000647)1.74692118
115Cystic liver disease (HP:0006706)1.74565749
116Delayed puberty (HP:0000823)1.74348242
117Febrile seizures (HP:0002373)1.71896899
118Abnormality of the costochondral junction (HP:0000919)1.71633310
119* Wide nasal bridge (HP:0000431)1.71503022
120Septate vagina (HP:0001153)1.71466420
121Broad-based gait (HP:0002136)1.71169626
122Cerebellar dysplasia (HP:0007033)1.70545113
123Epileptic encephalopathy (HP:0200134)1.70418983
124Autoimmune hemolytic anemia (HP:0001890)1.69953289
125Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.69184524
126Abnormality of the phalanges of the 5th finger (HP:0004213)1.68187961
127Patchy hypopigmentation of hair (HP:0011365)1.67206007
128Abnormality of the septum pellucidum (HP:0007375)1.66592064
129Alacrima (HP:0000522)1.61212437
130White forelock (HP:0002211)1.60057425
131Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.59313342
132Focal motor seizures (HP:0011153)1.56588534
133Retinal atrophy (HP:0001105)1.56173728
134Optic nerve hypoplasia (HP:0000609)1.55623389
135Nonprogressive disorder (HP:0003680)1.55460042
136Scanning speech (HP:0002168)1.53526575
137Gaze-evoked nystagmus (HP:0000640)1.53239770
138Abnormality of the fovea (HP:0000493)1.52933020
139Onion bulb formation (HP:0003383)1.52510297
140Corneal dystrophy (HP:0001131)1.50301967
141Confusion (HP:0001289)1.49004671
142Progressive cerebellar ataxia (HP:0002073)1.48920044
143Sensory axonal neuropathy (HP:0003390)1.48409662
144Astigmatism (HP:0000483)1.48334077
145Abnormality of the corticospinal tract (HP:0002492)1.48329305
146Chin dimple (HP:0010751)1.47247273
147Anomalous pulmonary venous return (HP:0010772)1.46676617
148Split foot (HP:0001839)1.44950669
149Abnormality of the renal medulla (HP:0100957)1.44775361
150Anencephaly (HP:0002323)1.42393845
151Thyroid-stimulating hormone excess (HP:0002925)1.41623498
152Slow saccadic eye movements (HP:0000514)1.40764565
153Abnormal ciliary motility (HP:0012262)1.40084342
154Cupped ear (HP:0000378)1.39744338
155Neurofibrillary tangles (HP:0002185)1.39710413
156Partial agenesis of the corpus callosum (HP:0001338)1.37725148
157Absent speech (HP:0001344)1.35567915
158Dysmetria (HP:0001310)1.35209986
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.33068345
160Abnormality of dental color (HP:0011073)1.32769956
161* Optic atrophy (HP:0000648)1.32190065
162Decreased lacrimation (HP:0000633)1.32124120
163Abnormality of the vitamin B12 metabolism (HP:0004341)1.31574635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT34.02138548
2FRK3.90971275
3TNIK3.88309294
4CASK3.65147672
5GRK13.36599746
6STK393.21722716
7PBK3.13443072
8MUSK2.66954270
9MAP4K22.58707028
10INSRR2.27104375
11VRK12.24722177
12OXSR12.23842303
13VRK22.14772443
14IRAK22.07018963
15MAP3K92.04407876
16PKN12.02052735
17CDK82.00813680
18KIT1.93523006
19ZAK1.87479892
20BMPR1B1.84869026
21BCKDK1.77626891
22PDK21.74689623
23NEK61.72805874
24ACVR1B1.70654450
25PIK3CA1.66582845
26PLK41.66114822
27MKNK21.63180354
28TAF11.60462871
29CLK11.57329812
30WNK11.54227707
31PRKG21.48105834
32PNCK1.47399350
33WNK41.45349157
34IKBKE1.36533210
35CDK31.35015359
36STK161.34736727
37EPHB11.33732950
38PRKD21.30419214
39GRK61.28738404
40PRPF4B1.20101882
41TGFBR11.17977210
42GRK71.15852412
43KDR1.15526024
44STK31.14297302
45NUAK11.10340587
46CAMK2D1.10036498
47BCR1.08724291
48SCYL21.08067661
49TBK11.07830079
50SGK2231.06790457
51SGK4941.06790457
52WNK31.06727294
53PLK21.06599319
54IRAK11.05152401
55BRD41.04752974
56IRAK41.04057894
57MAPKAPK51.03649715
58OBSCN1.02976345
59MAPK151.02206084
60TXK1.01840522
61CSF1R1.01288422
62CSNK1A1L1.00498960
63YES10.99939947
64EIF2AK30.99458603
65MAPK130.97589255
66MST40.96369222
67TRIM280.95790502
68ADRBK20.91395168
69MKNK10.88991940
70MARK20.86922456
71CAMK1G0.86884506
72PLK30.85107424
73CAMK2B0.84943915
74MAP2K70.82904941
75DMPK0.81870449
76TTK0.81000674
77TLK10.79924475
78CDK190.79200694
79CSNK1G10.78991627
80CSNK1G30.78741060
81UHMK10.78075157
82MAPK70.77010467
83CAMK2A0.75418388
84PINK10.75301662
85RPS6KA50.74130499
86BMPR20.74032948
87PIM20.74019151
88FGR0.73295635
89HIPK20.71055265
90PIM10.70402423
91BRSK20.69217492
92MAP3K70.69186897
93STK110.68722319
94MARK10.68408621
95PRKCI0.67051350
96PRKCE0.65748043
97EIF2AK20.64112332
98NME10.63653569
99CHEK20.63344991
100AKT30.63142272
101RPS6KA40.63141156
102ATR0.61110868
103CCNB10.60602320
104DYRK20.59748206
105MET0.59166732
106ADRBK10.58251898
107SRPK10.58125138
108PRKG10.56724853
109CDK90.56719906
110CSNK1G20.55535029
111PRKCQ0.55116810
112DYRK1A0.54214936
113EPHA40.54101956
114IKBKB0.53511275
115PRKD10.52895833
116MAP3K140.50612200
117ATM0.49367543
118ROCK20.48525684
119NLK0.47790087
120TAOK30.47776245
121FES0.47654716
122CAMK10.45309420
123TEC0.44410448
124CSNK1D0.44235844
125CDC70.43194175
126PDPK10.42893821
127FER0.42755578
128CAMK2G0.42509747
129NTRK30.41606053
130BLK0.41297167
131MST1R0.41015490
132PIK3CG0.40800941
133STK240.39164805
134SIK20.39103062
135MAPK120.39017353
136DYRK30.38706764
137RPS6KB20.38198103
138EPHA30.37929071
139PRKACA0.37899987
140PRKAA20.37121340
141SGK20.36945118
142EPHB20.36592506
143SIK30.36511004
144AURKB0.35591116
145BTK0.35193243
146SGK10.35160405
147TNK20.34147902
148STK40.34024339
149MARK30.34007263
150PLK10.33564804
151TESK20.31977341
152MAP2K60.31087608
153FGFR20.31084448
154ERBB40.30048829
155PRKCH0.29179272
156LCK0.28876334
157LYN0.27870908

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.75230917
2Primary immunodeficiency_Homo sapiens_hsa053402.63261148
3Steroid biosynthesis_Homo sapiens_hsa001002.42209012
4One carbon pool by folate_Homo sapiens_hsa006702.39315716
5Basal transcription factors_Homo sapiens_hsa030222.38458174
6Fanconi anemia pathway_Homo sapiens_hsa034602.33879454
7RNA polymerase_Homo sapiens_hsa030202.31892248
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15015511
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.12037194
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09980100
11Butanoate metabolism_Homo sapiens_hsa006502.01453827
12Phototransduction_Homo sapiens_hsa0474410.8012842
13Fatty acid elongation_Homo sapiens_hsa000621.89111234
14RNA degradation_Homo sapiens_hsa030181.88807813
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86154127
16Ether lipid metabolism_Homo sapiens_hsa005651.86068659
17Systemic lupus erythematosus_Homo sapiens_hsa053221.75943638
18Nicotine addiction_Homo sapiens_hsa050331.73293372
19Selenocompound metabolism_Homo sapiens_hsa004501.67671794
20Propanoate metabolism_Homo sapiens_hsa006401.65280224
21Nitrogen metabolism_Homo sapiens_hsa009101.61117306
22Serotonergic synapse_Homo sapiens_hsa047261.60863550
23Nucleotide excision repair_Homo sapiens_hsa034201.51209659
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48674870
25Sphingolipid metabolism_Homo sapiens_hsa006001.48525983
26Glutamatergic synapse_Homo sapiens_hsa047241.47311139
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46006393
28GABAergic synapse_Homo sapiens_hsa047271.45348898
29Mismatch repair_Homo sapiens_hsa034301.44659909
30Vitamin B6 metabolism_Homo sapiens_hsa007501.38727708
31Morphine addiction_Homo sapiens_hsa050321.36166425
32Proteasome_Homo sapiens_hsa030501.33313618
33Tryptophan metabolism_Homo sapiens_hsa003801.28587954
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27882388
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26065696
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.25124699
37Caffeine metabolism_Homo sapiens_hsa002321.19728645
38Circadian entrainment_Homo sapiens_hsa047131.17386633
39Antigen processing and presentation_Homo sapiens_hsa046121.17006450
40Mineral absorption_Homo sapiens_hsa049781.16980281
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11390939
42Axon guidance_Homo sapiens_hsa043601.09418662
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08194470
44Type I diabetes mellitus_Homo sapiens_hsa049401.06030142
45Linoleic acid metabolism_Homo sapiens_hsa005911.04625285
46Cholinergic synapse_Homo sapiens_hsa047251.03882890
47Pyrimidine metabolism_Homo sapiens_hsa002401.03182963
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02513416
49Oxidative phosphorylation_Homo sapiens_hsa001901.02119388
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01789683
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00696578
52Circadian rhythm_Homo sapiens_hsa047100.98838813
53Vitamin digestion and absorption_Homo sapiens_hsa049770.98552983
54Base excision repair_Homo sapiens_hsa034100.96778524
55Retinol metabolism_Homo sapiens_hsa008300.96329777
56Olfactory transduction_Homo sapiens_hsa047400.94075196
57Regulation of autophagy_Homo sapiens_hsa041400.93723170
58Cocaine addiction_Homo sapiens_hsa050300.92153619
59Taste transduction_Homo sapiens_hsa047420.90555264
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89363710
61Autoimmune thyroid disease_Homo sapiens_hsa053200.89261973
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89211114
63Synaptic vesicle cycle_Homo sapiens_hsa047210.86147367
64Chemical carcinogenesis_Homo sapiens_hsa052040.83686499
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82893932
66Protein export_Homo sapiens_hsa030600.82640102
67Sulfur metabolism_Homo sapiens_hsa009200.82117539
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81856164
69Dopaminergic synapse_Homo sapiens_hsa047280.80767867
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79877212
71Arachidonic acid metabolism_Homo sapiens_hsa005900.78329157
72Salivary secretion_Homo sapiens_hsa049700.77599092
73ABC transporters_Homo sapiens_hsa020100.76440596
74N-Glycan biosynthesis_Homo sapiens_hsa005100.74349844
75RNA transport_Homo sapiens_hsa030130.73563173
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73101045
77Cardiac muscle contraction_Homo sapiens_hsa042600.72687676
78DNA replication_Homo sapiens_hsa030300.71492515
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.71394418
80Insulin secretion_Homo sapiens_hsa049110.70825989
81Rheumatoid arthritis_Homo sapiens_hsa053230.70676232
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.70234019
83Fatty acid degradation_Homo sapiens_hsa000710.69083246
84Fatty acid metabolism_Homo sapiens_hsa012120.68950095
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67848319
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67663769
87Sulfur relay system_Homo sapiens_hsa041220.67330867
88Alzheimers disease_Homo sapiens_hsa050100.67262085
89Ras signaling pathway_Homo sapiens_hsa040140.67129060
90Long-term depression_Homo sapiens_hsa047300.64227703
91Peroxisome_Homo sapiens_hsa041460.63979437
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63645833
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.63245953
94cAMP signaling pathway_Homo sapiens_hsa040240.61921817
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61886251
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61349195
97Amphetamine addiction_Homo sapiens_hsa050310.60059100
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59049090
99Metabolic pathways_Homo sapiens_hsa011000.58180995
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.57612022
101Choline metabolism in cancer_Homo sapiens_hsa052310.57339971
102Calcium signaling pathway_Homo sapiens_hsa040200.55492575
103Histidine metabolism_Homo sapiens_hsa003400.55417093
104Collecting duct acid secretion_Homo sapiens_hsa049660.55039558
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54650732
106Graft-versus-host disease_Homo sapiens_hsa053320.54086730
107Ovarian steroidogenesis_Homo sapiens_hsa049130.52709077
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.52294970
109Fat digestion and absorption_Homo sapiens_hsa049750.50957253
110Pancreatic secretion_Homo sapiens_hsa049720.50705253
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50321247
112Inositol phosphate metabolism_Homo sapiens_hsa005620.49315921
113Renin secretion_Homo sapiens_hsa049240.48595824
114Hematopoietic cell lineage_Homo sapiens_hsa046400.48056814
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47812874
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47639749
117Wnt signaling pathway_Homo sapiens_hsa043100.47056441
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46947496
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46664281
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44836103
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.43471645
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.43126276
123Other glycan degradation_Homo sapiens_hsa005110.42390563
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.41423328
125Allograft rejection_Homo sapiens_hsa053300.41106334
126Tight junction_Homo sapiens_hsa045300.40252300
127Oxytocin signaling pathway_Homo sapiens_hsa049210.38346461
128Dilated cardiomyopathy_Homo sapiens_hsa054140.36980699
129Gastric acid secretion_Homo sapiens_hsa049710.36731235
130Asthma_Homo sapiens_hsa053100.36300034
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35378547
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34874123
133Glycerolipid metabolism_Homo sapiens_hsa005610.34569154
134Folate biosynthesis_Homo sapiens_hsa007900.34402344
135Malaria_Homo sapiens_hsa051440.34344465
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.34300703
137Parkinsons disease_Homo sapiens_hsa050120.31868392
138Non-homologous end-joining_Homo sapiens_hsa034500.31705997
139Chemokine signaling pathway_Homo sapiens_hsa040620.31684737
140MAPK signaling pathway_Homo sapiens_hsa040100.31337745
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31074504
142beta-Alanine metabolism_Homo sapiens_hsa004100.31000067
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30693265
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30438464
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30357295
146Purine metabolism_Homo sapiens_hsa002300.29945134
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29378520
148Huntingtons disease_Homo sapiens_hsa050160.28823089
149African trypanosomiasis_Homo sapiens_hsa051430.28739352
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28093494
151Dorso-ventral axis formation_Homo sapiens_hsa043200.27336396
152Alcoholism_Homo sapiens_hsa050340.27057795
153Hedgehog signaling pathway_Homo sapiens_hsa043400.26276674
154Fatty acid biosynthesis_Homo sapiens_hsa000610.25988946
155TGF-beta signaling pathway_Homo sapiens_hsa043500.25686129
156Herpes simplex infection_Homo sapiens_hsa051680.25148453

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