TULP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TULP2 is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this family have been identified in plants, vertebrates, and invertebrates. The TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.96691253
2axonemal dynein complex assembly (GO:0070286)9.94320344
3cilium or flagellum-dependent cell motility (GO:0001539)9.91984032
4spermatid development (GO:0007286)9.70320889
5motile cilium assembly (GO:0044458)9.26582932
6reproduction (GO:0000003)9.24544198
7regulation of cilium movement (GO:0003352)8.83874998
8cilium movement (GO:0003341)8.15150923
9piRNA metabolic process (GO:0034587)8.04027909
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.59059089
11male meiosis (GO:0007140)7.52095759
12synaptonemal complex organization (GO:0070193)7.46116281
13single fertilization (GO:0007338)7.43847122
14receptor recycling (GO:0001881)7.38999056
15synaptonemal complex assembly (GO:0007130)7.31192424
16sperm capacitation (GO:0048240)7.20445481
17negative regulation of inclusion body assembly (GO:0090084)6.86894588
18spermatogenesis (GO:0007283)6.66212431
19male gamete generation (GO:0048232)6.63848844
20fertilization (GO:0009566)6.35028881
21organic cation transport (GO:0015695)6.32870640
22microtubule depolymerization (GO:0007019)6.18218707
23gamete generation (GO:0007276)6.10961574
24regulation of inclusion body assembly (GO:0090083)5.73967450
25germ cell development (GO:0007281)5.56808566
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.49446324
27phosphatidylethanolamine metabolic process (GO:0046337)5.41120765
28phosphatidylethanolamine biosynthetic process (GO:0006646)5.32083168
29DNA methylation involved in gamete generation (GO:0043046)5.25530543
30male meiosis I (GO:0007141)5.23102086
31ventricular system development (GO:0021591)5.21727827
32regulation of microtubule-based movement (GO:0060632)5.16882593
33one-carbon compound transport (GO:0019755)5.04231437
34calcium ion-dependent exocytosis (GO:0017156)5.02735958
35chromosome organization involved in meiosis (GO:0070192)4.99440934
36cell recognition (GO:0008037)4.90728275
37microtubule severing (GO:0051013)4.89536748
38left/right pattern formation (GO:0060972)4.86996756
39multicellular organismal reproductive process (GO:0048609)4.82326325
40seminiferous tubule development (GO:0072520)4.82203051
41chromosome condensation (GO:0030261)4.66953853
42DNA packaging (GO:0006323)4.51574383
43meiotic nuclear division (GO:0007126)4.48249988
44negative regulation of Rho protein signal transduction (GO:0035024)4.46249707
45glycerol ether metabolic process (GO:0006662)4.44113654
46establishment of protein localization to Golgi (GO:0072600)4.20669854
47meiosis I (GO:0007127)4.17802941
48spermatid nucleus differentiation (GO:0007289)4.12864040
49ether metabolic process (GO:0018904)4.09239903
50genitalia morphogenesis (GO:0035112)4.00331383
51protein targeting to Golgi (GO:0000042)3.95226816
52multicellular organismal development (GO:0007275)3.88131839
53chaperone-mediated protein complex assembly (GO:0051131)3.87225970
54response to pheromone (GO:0019236)3.85760928
55notochord development (GO:0030903)3.81163792
56protein localization to cilium (GO:0061512)3.77187191
57meiotic cell cycle (GO:0051321)3.74841881
58trophoblast giant cell differentiation (GO:0060707)3.69019938
59protein polyglutamylation (GO:0018095)3.64817403
60retrograde transport, vesicle recycling within Golgi (GO:0000301)3.64740827
61monoubiquitinated protein deubiquitination (GO:0035520)3.63470783
62cornea development in camera-type eye (GO:0061303)3.61973839
63regulation of spindle checkpoint (GO:0090231)3.61961987
64single strand break repair (GO:0000012)3.57924647
65cellular response to ATP (GO:0071318)3.52049209
66rRNA methylation (GO:0031167)3.50237473
67protein K11-linked deubiquitination (GO:0035871)3.37450999
68high-density lipoprotein particle remodeling (GO:0034375)3.36943837
69protein refolding (GO:0042026)3.36592694
70histamine secretion (GO:0001821)3.36235592
71protein prenylation (GO:0018342)3.28362363
72prenylation (GO:0097354)3.28362363
73phagocytosis, recognition (GO:0006910)3.23770344
74sequestering of actin monomers (GO:0042989)3.22474909
75sexual reproduction (GO:0019953)3.21092946
76sphingoid metabolic process (GO:0046519)3.17452296
77reverse cholesterol transport (GO:0043691)3.17422777
78negative regulation of gluconeogenesis (GO:0045721)3.14643240
79pyrimidine dimer repair (GO:0006290)3.14160541
80centriole replication (GO:0007099)3.13881608
81intraciliary transport (GO:0042073)3.10644807
82microtubule polymerization or depolymerization (GO:0031109)3.10044900
83nucleus organization (GO:0006997)3.07323375
84inositol phosphate-mediated signaling (GO:0048016)3.06118103
85TOR signaling (GO:0031929)3.05638936
86regulation of cell proliferation involved in kidney development (GO:1901722)3.04799930
87decidualization (GO:0046697)3.03162958
88organelle membrane fusion (GO:0090174)3.02474703
89protein localization to Golgi apparatus (GO:0034067)2.98793949
90meiotic cell cycle process (GO:1903046)2.97352107
91carnitine transport (GO:0015879)2.97206886
92amino-acid betaine transport (GO:0015838)2.97206886
93interferon-gamma secretion (GO:0072643)2.96013464
94gene silencing by RNA (GO:0031047)2.93867119
95chondrocyte proliferation (GO:0035988)2.93862197
96synapsis (GO:0007129)2.91288572
97cellular response to zinc ion (GO:0071294)2.90571065
98regulation of transcription involved in cell fate commitment (GO:0060850)2.90042142
99mitotic sister chromatid cohesion (GO:0007064)2.88772135
100regulation of axon regeneration (GO:0048679)2.87281890
101regulation of neuron projection regeneration (GO:0070570)2.87281890
102cilium organization (GO:0044782)2.86930285
103nucleoside diphosphate phosphorylation (GO:0006165)2.86081034
104glycolytic process (GO:0006096)2.85889487
105polyol catabolic process (GO:0046174)2.85385429
106regulation of energy homeostasis (GO:2000505)2.84403969
107protein-cofactor linkage (GO:0018065)2.83972323
108sphingosine metabolic process (GO:0006670)2.83835945
109RNA localization (GO:0006403)2.83229819
110positive regulation of macrophage activation (GO:0043032)2.82393375
111ovulation from ovarian follicle (GO:0001542)2.82378761
112negative regulation of organelle assembly (GO:1902116)2.80315641
113carnitine transmembrane transport (GO:1902603)2.79992012
114alditol metabolic process (GO:0019400)2.79198452
115microtubule-based movement (GO:0007018)2.76570869
116urogenital system development (GO:0001655)2.75961517
117cilium assembly (GO:0042384)2.75314522
118auditory receptor cell stereocilium organization (GO:0060088)2.75029616
119peptidyl-threonine dephosphorylation (GO:0035970)2.73698881
120eosinophil chemotaxis (GO:0048245)2.73259032
121negative regulation of chemokine production (GO:0032682)2.73125751
122axoneme assembly (GO:0035082)2.72201823
123negative regulation of androgen receptor signaling pathway (GO:0060766)2.71645065
124cyclic nucleotide catabolic process (GO:0009214)2.71491859
125histamine transport (GO:0051608)2.71183257
126ER overload response (GO:0006983)2.70722355
127cilium morphogenesis (GO:0060271)2.70091880
128protein hydroxylation (GO:0018126)2.69274546
129RNA destabilization (GO:0050779)2.68838122
130plasma lipoprotein particle assembly (GO:0034377)2.68809512
131GTP biosynthetic process (GO:0006183)2.68739505
132sphingomyelin metabolic process (GO:0006684)2.68243040
133cellular component assembly involved in morphogenesis (GO:0010927)2.67984759
134rRNA modification (GO:0000154)2.67630625
135nuclear pore complex assembly (GO:0051292)2.67583279
136regulation of meiosis I (GO:0060631)2.66700434
137regulation of acrosome reaction (GO:0060046)2.65295638
138left/right axis specification (GO:0070986)2.64924720
139lactate metabolic process (GO:0006089)2.63504565
140regulation of centriole replication (GO:0046599)2.62429954
141cAMP catabolic process (GO:0006198)2.62195954
142keratinocyte development (GO:0003334)2.61042508
143sex differentiation (GO:0007548)2.60092104
144positive regulation of protein homooligomerization (GO:0032464)2.57167538
145cellular biogenic amine catabolic process (GO:0042402)2.56298646
146amine catabolic process (GO:0009310)2.56298646
147regulation of cilium assembly (GO:1902017)2.55838767
148phospholipid efflux (GO:0033700)2.55191905
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54776794
150centriole assembly (GO:0098534)2.52811859
151regulation of T-helper 2 cell differentiation (GO:0045628)2.52423236
152nephron tubule morphogenesis (GO:0072078)2.52278324
153nephron epithelium morphogenesis (GO:0072088)2.52278324
154platelet dense granule organization (GO:0060155)2.51321211
155glomerular visceral epithelial cell development (GO:0072015)2.50787296
156mesenchymal-epithelial cell signaling (GO:0060638)2.49536899
157positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.49199001
158thyroid gland development (GO:0030878)2.48714145
159fusion of sperm to egg plasma membrane (GO:0007342)13.8075725
160sperm motility (GO:0030317)13.6171473
161cell wall macromolecule catabolic process (GO:0016998)11.8262276
162cell wall macromolecule metabolic process (GO:0044036)11.8262276
163acrosome reaction (GO:0007340)11.6783697
164sperm-egg recognition (GO:0035036)11.4789544
165acrosome assembly (GO:0001675)11.3263986
166multicellular organism reproduction (GO:0032504)10.9695884
167plasma membrane fusion (GO:0045026)10.4834183
168binding of sperm to zona pellucida (GO:0007339)10.4458530
169cell-cell recognition (GO:0009988)10.3419442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.48034876
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.70691866
3EZH2_22144423_ChIP-Seq_EOC_Human3.62458413
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.99467839
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.91369122
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84541191
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72730699
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67021128
9VDR_22108803_ChIP-Seq_LS180_Human2.43980588
10* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28233915
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11585058
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.07819437
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06119564
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.01402046
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.0117897
16BCAT_22108803_ChIP-Seq_LS180_Human1.99615843
17P300_19829295_ChIP-Seq_ESCs_Human1.97290082
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91368922
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88822261
20STAT1_17558387_ChIP-Seq_HELA_Human1.87196394
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84753414
22CJUN_26792858_Chip-Seq_BT549_Human1.82598268
23FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80028384
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77154511
25ZNF274_21170338_ChIP-Seq_K562_Hela1.76442941
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75675790
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75264835
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75205809
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72607030
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68153032
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65026190
32ER_23166858_ChIP-Seq_MCF-7_Human1.64882065
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.64147529
34GATA3_21867929_ChIP-Seq_CD8_Mouse1.58922000
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58811618
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58737291
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58237914
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.58237874
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58020845
40FUS_26573619_Chip-Seq_HEK293_Human1.55637260
41VDR_24787735_ChIP-Seq_THP-1_Human1.54974674
42MYC_19829295_ChIP-Seq_ESCs_Human1.53596314
43AR_25329375_ChIP-Seq_VCAP_Human1.52949546
44STAT3_23295773_ChIP-Seq_U87_Human1.49462285
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.47840432
46SOX2_19829295_ChIP-Seq_ESCs_Human1.47016849
47NANOG_19829295_ChIP-Seq_ESCs_Human1.47016849
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.46359179
49GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.45814845
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41993892
51FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41675002
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40819972
53GATA1_22025678_ChIP-Seq_K562_Human1.39899092
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.39551496
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39053256
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.38998993
57CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38010929
58SMAD4_21799915_ChIP-Seq_A2780_Human1.36393358
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36360146
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.36360146
61KDM2B_26808549_Chip-Seq_REH_Human1.36028133
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.36015752
63AR_21572438_ChIP-Seq_LNCaP_Human1.35813102
64P53_21459846_ChIP-Seq_SAOS-2_Human1.35599832
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34833576
66CBP_20019798_ChIP-Seq_JUKART_Human1.34833576
67TCF4_23295773_ChIP-Seq_U87_Human1.34636397
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34185796
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.33055462
70GBX2_23144817_ChIP-Seq_PC3_Human1.32603596
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32500458
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32478996
73CDX2_22108803_ChIP-Seq_LS180_Human1.32172063
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31964131
75TAF15_26573619_Chip-Seq_HEK293_Human1.30535554
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.30013126
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29734851
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28841657
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28787987
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.28063550
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.27713962
82GF1_26923725_Chip-Seq_HPCs_Mouse1.27327950
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.26723099
84RAD21_21589869_ChIP-Seq_MESCs_Mouse1.26443591
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.26309513
86HNFA_21074721_ChIP-Seq_CACO-2_Human1.25762069
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.24743938
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.24532461
89IGF1R_20145208_ChIP-Seq_DFB_Human1.24033110
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23822850
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23234969
92ETV1_20927104_ChIP-Seq_GIST48_Human1.22766799
93RBPJ_21746931_ChIP-Seq_IB4_Human1.22759106
94SMRT_27268052_Chip-Seq_Bcells_Human1.22160640
95TCF4_22108803_ChIP-Seq_LS180_Human1.22084280
96SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.21775084
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21019230
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19455473
99TP53_22573176_ChIP-Seq_HFKS_Human1.19245347
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.19135499
101PHF8_20622853_ChIP-Seq_HELA_Human1.19049228
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18296221
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17827208
104CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17278202
105HOXB7_26014856_ChIP-Seq_BT474_Human1.16917185
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16556596
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16207400
108EWS_26573619_Chip-Seq_HEK293_Human1.15379108
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.14901869
110TBL1_22424771_ChIP-Seq_293T_Human1.14061250
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13595759
112RUNX2_22187159_ChIP-Seq_PCA_Human1.13396856
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13305096
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12229250
115SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11974870
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.11502276
117TP63_23658742_ChIP-Seq_EP156T_Human1.11432516
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11384268
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11384268
120SPI1_26923725_Chip-Seq_HPCs_Mouse1.11378073
121* RAC3_21632823_ChIP-Seq_H3396_Human1.11153547
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10970360
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10842407
124NCOR_22424771_ChIP-Seq_293T_Human1.10839219
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.10668925
126AHR_22903824_ChIP-Seq_MCF-7_Human1.09842806
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09741818
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08868427
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08455211
130EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08356198
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.08167855
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07973277
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.07147821
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06773024
135DROSHA_22980978_ChIP-Seq_HELA_Human1.06771663
136MYC_27129775_Chip-Seq_CORNEA_Mouse1.06581656
137TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06264102
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05817432
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04462956
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04441158
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04372285
142ERG_20517297_ChIP-Seq_VCAP_Human1.03836131
143ESET_19884257_ChIP-Seq_ESCs_Mouse1.03405289
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02717184
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02502511
146RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01566888
147GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00751934
148RARA_24833708_ChIP-Seq_LIVER_Mouse1.00554980
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00194984
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.99964669
151OCT4_18555785_Chip-Seq_ESCs_Mouse0.99683642
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.99137486
153RNF2_27304074_Chip-Seq_NSC_Mouse0.99014261
154CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98357662
155SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97448339
156REST_21632747_ChIP-Seq_MESCs_Mouse0.97240896
157TET1_21451524_ChIP-Seq_MESCs_Mouse0.95428460
158JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95027779
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93498867
160PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93343126
161CTCF_20526341_ChIP-Seq_ESCs_Human0.93178908
162RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92327396
163NFYB_21822215_ChIP-Seq_K562_Human0.91415340
164OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91231374
165NANOG_20526341_ChIP-Seq_ESCs_Human0.90883947
166STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90332019
167FLI1_21867929_ChIP-Seq_CD8_Mouse0.90267306
168LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89562168
169KLF4_18555785_Chip-Seq_ESCs_Mouse0.88920886
170EZH2_27294783_Chip-Seq_NPCs_Mouse0.88550487
171P53_22387025_ChIP-Seq_ESCs_Mouse0.88513531
172GF1B_26923725_Chip-Seq_HPCs_Mouse0.87242942
173ELF1_20517297_ChIP-Seq_JURKAT_Human0.87093731
174BCOR_27268052_Chip-Seq_Bcells_Human0.86866916
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86349808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04290534
2MP0001929_abnormal_gametogenesis5.57585677
3MP0008877_abnormal_DNA_methylation4.43911113
4MP0002210_abnormal_sex_determination3.57588609
5MP0002161_abnormal_fertility/fecundity3.30820508
6MP0009840_abnormal_foam_cell3.11891475
7MP0002254_reproductive_system_inflammat3.09772794
8MP0001145_abnormal_male_reproductive3.03666044
9MP0005408_hypopigmentation3.00443607
10MP0005670_abnormal_white_adipose2.78462031
11MP0000653_abnormal_sex_gland2.63448102
12MP0006054_spinal_hemorrhage2.52514903
13MP0002653_abnormal_ependyma_morphology2.47441599
14MP0002837_dystrophic_cardiac_calcinosis2.46223823
15MP0003191_abnormal_cellular_cholesterol2.42480811
16MP0003718_maternal_effect2.41683632
17MP0005275_abnormal_skin_tensile2.30738193
18MP0004484_altered_response_of2.28985230
19MP0005503_abnormal_tendon_morphology2.27269037
20MP0005410_abnormal_fertilization16.0441696
21MP0001986_abnormal_taste_sensitivity1.98276107
22MP0000372_irregular_coat_pigmentation1.97634927
23MP0001879_abnormal_lymphatic_vessel1.78263967
24MP0003186_abnormal_redox_activity1.74163089
25MP0002160_abnormal_reproductive_system1.73389624
26MP0008995_early_reproductive_senescence1.61946267
27MP0008438_abnormal_cutaneous_collagen1.61118442
28MP0003136_yellow_coat_color1.60354303
29MP0002938_white_spotting1.57789014
30MP0003828_pulmonary_edema1.56670263
31MP0005171_absent_coat_pigmentation1.55183116
32MP0005623_abnormal_meninges_morphology1.48880529
33MP0001501_abnormal_sleep_pattern1.48014082
34MP0004215_abnormal_myocardial_fiber1.46538952
35MP0001756_abnormal_urination1.45615533
36MP0005310_abnormal_salivary_gland1.44873516
37MP0003878_abnormal_ear_physiology1.41739897
38MP0005377_hearing/vestibular/ear_phenot1.41739897
39MP0005395_other_phenotype1.37250920
40MP0010329_abnormal_lipoprotein_level1.37144672
41MP0003646_muscle_fatigue1.30096388
42MP0002127_abnormal_cardiovascular_syste1.27573878
43MP0010368_abnormal_lymphatic_system1.26286207
44MP0000516_abnormal_urinary_system1.25511805
45MP0005367_renal/urinary_system_phenotyp1.25511805
46MP0002282_abnormal_trachea_morphology1.23800784
47MP0005647_abnormal_sex_gland1.22276222
48MP0009764_decreased_sensitivity_to1.16089005
49MP0003195_calcinosis1.16052748
50MP0002108_abnormal_muscle_morphology1.15047233
51MP0008058_abnormal_DNA_repair1.14066052
52MP0008872_abnormal_physiological_respon1.11595928
53MP0004084_abnormal_cardiac_muscle1.10929765
54MP0010386_abnormal_urinary_bladder1.09839925
55MP0004233_abnormal_muscle_weight1.09689179
56MP0000470_abnormal_stomach_morphology1.09651262
57MP0005423_abnormal_somatic_nervous1.05206209
58MP0002168_other_aberrant_phenotype1.03742275
59MP0000371_diluted_coat_color1.02935628
60MP0001485_abnormal_pinna_reflex1.02031799
61MP0005164_abnormal_response_to0.99902942
62MP0002136_abnormal_kidney_physiology0.99207083
63MP0001765_abnormal_ion_homeostasis0.99055963
64MP0000015_abnormal_ear_pigmentation0.98879164
65MP0004510_myositis0.97123886
66MP0002060_abnormal_skin_morphology0.94722417
67MP0009643_abnormal_urine_homeostasis0.94041015
68MP0005167_abnormal_blood-brain_barrier0.93816272
69MP0005166_decreased_susceptibility_to0.90946958
70MP0005389_reproductive_system_phenotype0.88167334
71MP0008004_abnormal_stomach_pH0.86914619
72MP0000613_abnormal_salivary_gland0.86344738
73MP0005332_abnormal_amino_acid0.84888226
74MP0005084_abnormal_gallbladder_morpholo0.84255109
75MP0005508_abnormal_skeleton_morphology0.80534110
76MP0005360_urolithiasis0.77434747
77MP0003787_abnormal_imprinting0.76501006
78MP0010094_abnormal_chromosome_stability0.76055213
79MP0003115_abnormal_respiratory_system0.75682966
80MP0001666_abnormal_nutrient_absorption0.75494913
81MP0003786_premature_aging0.75134157
82MP0008057_abnormal_DNA_replication0.75008702
83MP0002693_abnormal_pancreas_physiology0.73751745
84MP0009278_abnormal_bone_marrow0.72370614
85MP0001984_abnormal_olfaction0.72251897
86MP0001191_abnormal_skin_condition0.71942228
87MP0001486_abnormal_startle_reflex0.71293590
88MP0001243_abnormal_dermal_layer0.70918586
89MP0002148_abnormal_hypersensitivity_rea0.69571561
90MP0000003_abnormal_adipose_tissue0.69409061
91MP0001545_abnormal_hematopoietic_system0.67565467
92MP0005397_hematopoietic_system_phenotyp0.67565467
93MP0000249_abnormal_blood_vessel0.65388276
94MP0002234_abnormal_pharynx_morphology0.64907402
95MP0005646_abnormal_pituitary_gland0.64205103
96MP0002075_abnormal_coat/hair_pigmentati0.63776587
97MP0008875_abnormal_xenobiotic_pharmacok0.63127815
98MP0003879_abnormal_hair_cell0.63013474
99MP0005666_abnormal_adipose_tissue0.62699718
100MP0001502_abnormal_circadian_rhythm0.60787229
101MP0003633_abnormal_nervous_system0.60756974
102MP0001849_ear_inflammation0.60655288
103MP0005379_endocrine/exocrine_gland_phen0.59915916
104MP0000343_altered_response_to0.59808427
105MP0008961_abnormal_basal_metabolism0.59541682
106MP0001764_abnormal_homeostasis0.58420114
107MP0003699_abnormal_female_reproductive0.56971425
108MP0001293_anophthalmia0.56830930
109MP0002928_abnormal_bile_duct0.54035154
110MP0003111_abnormal_nucleus_morphology0.53513705
111MP0000569_abnormal_digit_pigmentation0.53313306
112MP0001324_abnormal_eye_pigmentation0.52524599
113MP0009046_muscle_twitch0.51927672
114MP0005636_abnormal_mineral_homeostasis0.51013201
115MP0003011_delayed_dark_adaptation0.50657931
116MP0000534_abnormal_ureter_morphology0.50462853
117MP0004133_heterotaxia0.47675272
118MP0008007_abnormal_cellular_replicative0.46897793
119MP0001119_abnormal_female_reproductive0.46740256
120MP0005253_abnormal_eye_physiology0.46612725
121MP0009115_abnormal_fat_cell0.46455619
122MP0000358_abnormal_cell_content/0.45438538
123MP0002102_abnormal_ear_morphology0.43461362
124MP0005391_vision/eye_phenotype0.41380849
125MP0003942_abnormal_urinary_system0.38400699
126MP0004808_abnormal_hematopoietic_stem0.37130994
127MP0003045_fibrosis0.36329439
128MP0003950_abnormal_plasma_membrane0.32881513
129MP0002132_abnormal_respiratory_system0.30596422
130MP0002971_abnormal_brown_adipose0.29788376
131MP0003077_abnormal_cell_cycle0.29746658
132MP0002092_abnormal_eye_morphology0.29450514
133MP0002405_respiratory_system_inflammati0.28850350
134MP0004742_abnormal_vestibular_system0.28738039
135MP0004134_abnormal_chest_morphology0.27689829
136MP0002295_abnormal_pulmonary_circulatio0.27399746
137MP0002269_muscular_atrophy0.27320742
138MP0010307_abnormal_tumor_latency0.27134312
139MP0005375_adipose_tissue_phenotype0.26761110
140MP0003936_abnormal_reproductive_system0.26705123
141MP0004036_abnormal_muscle_relaxation0.26530867
142MP0001873_stomach_inflammation0.26254943
143MP0000685_abnormal_immune_system0.26014827
144MP0003315_abnormal_perineum_morphology0.25328363
145MP0005174_abnormal_tail_pigmentation0.25310222
146MP0000313_abnormal_cell_death0.22961999
147MP0001730_embryonic_growth_arrest0.22716646
148MP0000678_abnormal_parathyroid_gland0.22650755
149MP0006036_abnormal_mitochondrial_physio0.22457392
150MP0003329_amyloid_beta_deposits0.22137658
151MP0001348_abnormal_lacrimal_gland0.21172287
152MP0005551_abnormal_eye_electrophysiolog0.21148417
153MP0001661_extended_life_span0.21106028
154MP0002876_abnormal_thyroid_physiology0.19099315
155MP0001727_abnormal_embryo_implantation0.18068661
156MP0003943_abnormal_hepatobiliary_system0.16586967
157MP0005075_abnormal_melanosome_morpholog0.16450410
158MP0001851_eye_inflammation0.16120601
159MP0002169_no_abnormal_phenotype0.16019888
160MP0003948_abnormal_gas_homeostasis0.15947289
161MP0003861_abnormal_nervous_system0.15804843
162MP0002873_normal_phenotype0.15588871
163MP0002084_abnormal_developmental_patter0.15113270
164MP0004019_abnormal_vitamin_homeostasis0.14397231
165MP0001672_abnormal_embryogenesis/_devel0.14325564
166MP0005380_embryogenesis_phenotype0.14325564
167MP0003959_abnormal_lean_body0.13877606
168MP0006072_abnormal_retinal_apoptosis0.13067545
169MP0004264_abnormal_extraembryonic_tissu0.12882939
170MP0001919_abnormal_reproductive_system0.12256281
171MP0000049_abnormal_middle_ear0.10501589

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.05875057
2Abnormal respiratory epithelium morphology (HP:0012253)8.96313082
3Abnormal respiratory motile cilium morphology (HP:0005938)8.96313082
4Rhinitis (HP:0012384)7.39023123
5Abnormal ciliary motility (HP:0012262)7.15765296
6Chronic bronchitis (HP:0004469)7.00852439
7Infertility (HP:0000789)6.96766908
8Nasal polyposis (HP:0100582)6.38545395
9Severe visual impairment (HP:0001141)6.28554854
10Abnormality of the nasal mucosa (HP:0000433)5.28833831
11Male infertility (HP:0003251)5.15206357
12Bronchitis (HP:0012387)4.74705945
13Tongue fasciculations (HP:0001308)4.65198605
14Bronchiectasis (HP:0002110)4.40194805
15Nephronophthisis (HP:0000090)4.30843768
16Muscle fibrillation (HP:0010546)4.07690325
17Keratoconus (HP:0000563)3.99997841
18Increased corneal curvature (HP:0100692)3.99997841
19Abnormal rod and cone electroretinograms (HP:0008323)3.97427043
20Abnormal spermatogenesis (HP:0008669)3.96277822
21Attenuation of retinal blood vessels (HP:0007843)3.92727319
22Clumsiness (HP:0002312)3.57595410
23Pendular nystagmus (HP:0012043)3.51818231
24Abnormality of the renal medulla (HP:0100957)3.50315938
25Recurrent sinusitis (HP:0011108)3.38522814
26Tubulointerstitial nephritis (HP:0001970)3.35456669
27Recurrent otitis media (HP:0000403)3.25057481
28Abnormality of DNA repair (HP:0003254)3.24920628
29Recurrent bronchitis (HP:0002837)3.23941616
30Cone-rod dystrophy (HP:0000548)3.17405231
31Gonadotropin excess (HP:0000837)3.09926578
32Absent rod-and cone-mediated responses on ERG (HP:0007688)3.02982353
33Impulsivity (HP:0100710)2.99463101
34Abnormality of dental color (HP:0011073)2.95174750
35Hypoplastic ischia (HP:0003175)2.89351490
36Hypokinesia (HP:0002375)2.87469670
37Hyperlipoproteinemia (HP:0010980)2.76460372
38Azoospermia (HP:0000027)2.75407802
39Patent foramen ovale (HP:0001655)2.74122745
40Enlarged epiphyses (HP:0010580)2.70055273
41Tubulointerstitial abnormality (HP:0001969)2.68801182
42Congenital sensorineural hearing impairment (HP:0008527)2.65116346
43Hypoalphalipoproteinemia (HP:0003233)2.65032506
44Abnormality of the nasal septum (HP:0000419)2.64296065
45Chronic hepatic failure (HP:0100626)2.60905310
46Ectropion (HP:0000656)2.54985023
47Tubular atrophy (HP:0000092)2.54691562
48Hypoplastic left heart (HP:0004383)2.53354598
49Abnormality of midbrain morphology (HP:0002418)2.51420372
50Molar tooth sign on MRI (HP:0002419)2.51420372
51Amelogenesis imperfecta (HP:0000705)2.49672283
52Metaphyseal dysplasia (HP:0100255)2.48440070
53Abnormality of the ischium (HP:0003174)2.45697343
54Albinism (HP:0001022)2.42117847
55Follicular hyperkeratosis (HP:0007502)2.41324194
56Pancreatic cysts (HP:0001737)2.40175489
57Entropion (HP:0000621)2.36582981
58Bony spicule pigmentary retinopathy (HP:0007737)2.33728765
59Mesangial abnormality (HP:0001966)2.33201542
60Hypolipoproteinemia (HP:0010981)2.31965299
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.28751587
62Hypoplasia of the fovea (HP:0007750)2.28751587
63Medial flaring of the eyebrow (HP:0010747)2.28077522
64Congenital stationary night blindness (HP:0007642)2.17809106
65Hyperkalemia (HP:0002153)2.15253852
66Keratitis (HP:0000491)2.12764698
67Chorioretinal atrophy (HP:0000533)2.11845286
68Abnormal gallbladder physiology (HP:0012438)2.11635355
69Cholecystitis (HP:0001082)2.11635355
70Recurrent corneal erosions (HP:0000495)2.10526723
71Poikiloderma (HP:0001029)2.07463984
72Cerebellar dysplasia (HP:0007033)2.06118959
73Decreased central vision (HP:0007663)2.05513038
74Tubulointerstitial fibrosis (HP:0005576)2.04112534
75Hypoalbuminemia (HP:0003073)2.04096837
76Abnormal albumin level (HP:0012116)2.04096837
77Pigmentary retinal degeneration (HP:0001146)2.03768130
78Alopecia of scalp (HP:0002293)2.03716130
79Abnormality of the renal cortex (HP:0011035)2.02058094
80Postaxial foot polydactyly (HP:0001830)2.02057060
81Stage 5 chronic kidney disease (HP:0003774)2.00001067
82Dynein arm defect of respiratory motile cilia (HP:0012255)13.2205902
83Absent/shortened dynein arms (HP:0200106)13.2205902
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9144513
85Febrile seizures (HP:0002373)1.97994687
86Hypoplastic heart (HP:0001961)1.97241752
87Aplasia/Hypoplasia of the earlobes (HP:0009906)1.97051083
88Depressed nasal tip (HP:0000437)1.96595331
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.95986426
90Abolished electroretinogram (ERG) (HP:0000550)1.95729372
91Abnormality of the frontal sinuses (HP:0002687)1.95338070
92Neoplasm of the oral cavity (HP:0100649)1.95291477
93Dyschromatopsia (HP:0007641)1.95050954
94Photophobia (HP:0000613)1.94788666
95Renal dysplasia (HP:0000110)1.93223012
96Tetany (HP:0001281)1.91866017
97Congenital hepatic fibrosis (HP:0002612)1.89405642
98Spontaneous abortion (HP:0005268)1.88299186
99Abnormal biliary tract physiology (HP:0012439)1.85603455
100Bile duct proliferation (HP:0001408)1.85603455
101Short middle phalanx of the 5th finger (HP:0004220)1.83682124
102Squamous cell carcinoma (HP:0002860)1.81452195
103Spastic tetraparesis (HP:0001285)1.80624884
104Abnormality of incisor morphology (HP:0011063)1.78748304
105Astigmatism (HP:0000483)1.77570449
106Fibular hypoplasia (HP:0003038)1.74166255
107Glycosuria (HP:0003076)1.73294372
108Abnormality of urine glucose concentration (HP:0011016)1.73294372
109Lip pit (HP:0100267)1.72544046
110Upper limb muscle weakness (HP:0003484)1.71216049
111Heterotopia (HP:0002282)1.71202288
112Choroideremia (HP:0001139)1.70043100
113Abnormality of permanent molar morphology (HP:0011071)1.68835183
114Abnormality of the dental root (HP:0006486)1.68835183
115Taurodontia (HP:0000679)1.68835183
116Abnormality of the parathyroid morphology (HP:0011766)1.68808441
117Abnormality of the lower motor neuron (HP:0002366)1.68310595
118Anhidrosis (HP:0000970)1.67544459
119Bulbous nose (HP:0000414)1.67195608
120Poor eye contact (HP:0000817)1.65800862
121Abnormality of the fovea (HP:0000493)1.65686133
122Chronic sinusitis (HP:0011109)1.64890197
123Bell-shaped thorax (HP:0001591)1.63982197
124Abnormality of renal excretion (HP:0011036)1.63949289
125Abnormal drinking behavior (HP:0030082)1.63757250
126Polydipsia (HP:0001959)1.63757250
127Autoamputation (HP:0001218)1.63118291
128Short ribs (HP:0000773)1.61787840
129Ectopic kidney (HP:0000086)1.60760081
130Aplasia/Hypoplasia of the macula (HP:0008059)1.60661014
131Type II lissencephaly (HP:0007260)1.60653739
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58931845
133Cystic liver disease (HP:0006706)1.57908062
134Abnormality of molar morphology (HP:0011070)1.57905403
135Abnormality of molar (HP:0011077)1.57905403
136Abnormality of the dental pulp (HP:0006479)1.52922965
137Deformed sella turcica (HP:0002681)1.51643832
138Hemorrhage of the eye (HP:0011885)1.50402223
139Abnormality of dentin (HP:0010299)1.49258431
140Pancreatic fibrosis (HP:0100732)1.48056269
141Double outlet right ventricle (HP:0001719)1.46539009
142Congenital malformation of the right heart (HP:0011723)1.46539009
143Absent frontal sinuses (HP:0002688)1.46501350
144Facial cleft (HP:0002006)1.46097350
145Oculomotor apraxia (HP:0000657)1.44347312
146Postaxial hand polydactyly (HP:0001162)1.40952142
147True hermaphroditism (HP:0010459)1.39217695
148Abnormal urine output (HP:0012590)1.38503027
149J-shaped sella turcica (HP:0002680)1.37773444
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.34647961
151Male pseudohermaphroditism (HP:0000037)1.32462290
152Aplasia/Hypoplasia of the lens (HP:0008063)1.28930298
153Amyotrophic lateral sclerosis (HP:0007354)1.26151066
154Impaired proprioception (HP:0010831)1.24891509
155Nephropathy (HP:0000112)1.24878911
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.24520279
157Neurofibrillary tangles (HP:0002185)1.24337936
158Short thorax (HP:0010306)1.24097164
159Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.23186854
160Absent epiphyses (HP:0010577)1.23186854
161Microglossia (HP:0000171)1.20208896
162Supernumerary spleens (HP:0009799)1.19913625
163Easy fatigability (HP:0003388)1.19568247
164Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19223898
165Transposition of the great arteries (HP:0001669)1.18578260
166Abnormal connection of the cardiac segments (HP:0011545)1.18578260
167Abnormal ventriculo-arterial connection (HP:0011563)1.18578260
168Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.18333168
169Median cleft lip (HP:0000161)1.17702731
170Polyuria (HP:0000103)1.17376393
171Asymmetric septal hypertrophy (HP:0001670)1.16814924
172Macular degeneration (HP:0000608)1.15207936
173Broad distal phalanx of finger (HP:0009836)1.12582074
174Occipital encephalocele (HP:0002085)1.10667607
175Abnormality of the sella turcica (HP:0002679)1.10380496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.90126431
2PDK37.90126431
3TESK16.28511976
4PDK25.27503066
5PRKD35.18813760
6ICK4.57997270
7NUAK14.10220925
8FRK4.04374259
9MAP3K33.56991878
10TRIM282.87675570
11PIK3CG2.71030296
12ACVR1B2.50641200
13DDR22.33124597
14TLK12.26900617
15PNCK2.24105959
16PTK2B2.23113999
17SIK32.21547066
18WNK42.20008469
19STK392.08530466
20NEK21.91670860
21ADRBK21.89737643
22PBK1.87207514
23BMPR1B1.86411713
24INSRR1.77929262
25STK381.73399809
26DYRK1B1.66218592
27MST41.65721466
28PLK21.64007376
29NLK1.56276029
30EIF2AK31.46002625
31TEC1.44409708
32TNIK1.38735446
33LATS11.37276187
34FER1.33005544
35OXSR11.25494461
36CASK1.25092170
37PAK31.24347189
38TYRO31.24134271
39MAPK151.22737957
40TAOK21.21181216
41ZAK1.13255052
42BRD41.12937350
43DYRK31.07821403
44GRK11.05444226
45PDK11.02922721
46STK161.00451530
47MKNK20.94852694
48BMPR20.94217286
49STK110.93951358
50PHKG20.91724107
51PHKG10.91724107
52BLK0.89521202
53BCR0.88917640
54TAOK30.87330280
55KSR10.85168428
56PASK0.83455468
57WNK10.81881304
58ADRBK10.81342516
59IKBKB0.80359526
60MAP4K20.78133495
61DYRK1A0.75457232
62IRAK10.75184068
63STK30.74202994
64EEF2K0.73968267
65RIPK40.70488524
66GSK3A0.69094094
67TGFBR20.68319899
68PRKAA20.66464935
69LATS20.65893901
70ROCK10.65775771
71CAMK1G0.64934213
72CCNB10.61958413
73CHEK20.61897949
74TTK0.61758368
75EPHA30.61464962
76ITK0.61386601
77PDPK10.57864204
78TRPM70.57320711
79MAP2K60.57027754
80TXK0.54203954
81PINK10.51083576
82PRKCE0.49401848
83FGFR20.49123317
84WEE10.48918473
85CHEK10.45439506
86PAK10.45349090
87TESK20.45333736
88VRK10.43679294
89PAK40.43424945
90ATR0.41816782
91TAF10.41288466
92PAK20.40833933
93PLK40.40717159
94CDK120.39387515
95IRAK20.39136349
96ATM0.36336624
97MTOR0.36113790
98STK38L0.35562176
99PRKD10.33962302
100NEK60.32128493
101CDC42BPA0.31598556
102BRSK20.30279995
103FGFR30.30025164
104MARK20.28979907
105LMTK20.28710398
106GRK50.27743152
107MAP3K100.27255880
108CDC70.25142793
109MAPKAPK20.24649301
110CAMK2A0.24505810
111RPS6KA50.24185593
112MAP3K20.24033404
113NTRK20.23695368
114PLK30.23088250
115IGF1R0.22418185
116MAP2K10.21160134
117MAPKAPK50.20842609
118EIF2AK20.20256081
119PLK10.19283493
120PTK60.19107875
121STK100.18628155
122PRKCG0.17186960
123AKT30.17008958
124CLK10.16747874
125TIE10.15037288
126CDK60.14715081
127MARK30.14473675
128PKN10.14451461
129PRKAA10.14435441
130RPS6KB10.14191192
131MUSK0.13623731
132PIM10.11821533
133RPS6KA10.09302680
134PRKCQ0.09287816
135CDK40.09089970
136CSNK2A10.08838427
137GSK3B0.08489929
138PRKCZ0.07629484
139CDK20.06817147
140BRSK10.05975385
141MAPKAPK30.05970338
142CAMKK10.05604530
143CDK10.05361441
144CSF1R0.05279070
145WNK30.05270752
146EPHB10.03440960
147ZAP700.02983193
148CSNK1D0.02634877
149CSNK2A20.02549816
150PRKACB0.01095063
151PDGFRB0.01084355
152MAPK80.00601934
153AURKB0.00499777
154CSK0.00405287
155MAPK10.00344702
156MAP2K20.00112840
157PRKCD0.00067043
158YES1-0.0295107
159STK4-0.0288856
160AURKA-0.0254213
161TBK1-0.0189701
162PRKG1-0.0176436
163EGFR-0.0171902
164PRKG2-0.0155364
165CHUK-0.0141800
166PRKDC-0.0011543
167CDK7-0.0008415

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.44799274
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.36796541
3Vitamin B6 metabolism_Homo sapiens_hsa007503.77990849
4Pyruvate metabolism_Homo sapiens_hsa006203.51579408
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.31683725
6Linoleic acid metabolism_Homo sapiens_hsa005913.14195080
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.96586956
8Folate biosynthesis_Homo sapiens_hsa007902.86457575
9Caffeine metabolism_Homo sapiens_hsa002322.67360343
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.65018333
11Basal transcription factors_Homo sapiens_hsa030222.58460587
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.53837984
13Propanoate metabolism_Homo sapiens_hsa006402.53189083
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49847988
15Glucagon signaling pathway_Homo sapiens_hsa049222.49783806
16Sphingolipid metabolism_Homo sapiens_hsa006002.30320528
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17284555
18Carbohydrate digestion and absorption_Homo sapiens_hsa049732.16698504
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.14495229
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04110853
21Glycerolipid metabolism_Homo sapiens_hsa005612.02335189
22Selenocompound metabolism_Homo sapiens_hsa004501.96728358
23African trypanosomiasis_Homo sapiens_hsa051431.95222647
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93525877
25Fanconi anemia pathway_Homo sapiens_hsa034601.92893466
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.92793247
27PPAR signaling pathway_Homo sapiens_hsa033201.82707962
28Dorso-ventral axis formation_Homo sapiens_hsa043201.78150691
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.76104709
30Protein export_Homo sapiens_hsa030601.72939920
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.70927655
32Pentose phosphate pathway_Homo sapiens_hsa000301.70349623
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.66138347
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62511021
35p53 signaling pathway_Homo sapiens_hsa041151.60607651
36Antigen processing and presentation_Homo sapiens_hsa046121.56676504
37Fructose and mannose metabolism_Homo sapiens_hsa000511.55885826
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55330628
39Oocyte meiosis_Homo sapiens_hsa041141.53322937
40Arginine and proline metabolism_Homo sapiens_hsa003301.47498018
41Mineral absorption_Homo sapiens_hsa049781.43719169
42Ether lipid metabolism_Homo sapiens_hsa005651.39323553
43mRNA surveillance pathway_Homo sapiens_hsa030151.34469551
44Fatty acid degradation_Homo sapiens_hsa000711.34314666
45RNA transport_Homo sapiens_hsa030131.34011474
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31055721
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.26967029
48Complement and coagulation cascades_Homo sapiens_hsa046101.26273895
49Amphetamine addiction_Homo sapiens_hsa050311.25212275
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24466624
51Fat digestion and absorption_Homo sapiens_hsa049751.23242151
52Fatty acid metabolism_Homo sapiens_hsa012121.22259948
53Phototransduction_Homo sapiens_hsa047441.15555218
54Rheumatoid arthritis_Homo sapiens_hsa053231.13073772
55Ovarian steroidogenesis_Homo sapiens_hsa049131.12875415
56RNA polymerase_Homo sapiens_hsa030201.09732814
57Butanoate metabolism_Homo sapiens_hsa006501.08319710
58Carbon metabolism_Homo sapiens_hsa012001.06662313
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.05980403
60One carbon pool by folate_Homo sapiens_hsa006701.05726600
61Purine metabolism_Homo sapiens_hsa002301.04280667
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02860560
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01647405
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00162449
65Type I diabetes mellitus_Homo sapiens_hsa049400.99915772
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98583502
67Olfactory transduction_Homo sapiens_hsa047400.96693160
68Renin secretion_Homo sapiens_hsa049240.95869924
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95156233
70Glutathione metabolism_Homo sapiens_hsa004800.93853588
71Arachidonic acid metabolism_Homo sapiens_hsa005900.93266407
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91951394
73Hedgehog signaling pathway_Homo sapiens_hsa043400.91823557
74Cardiac muscle contraction_Homo sapiens_hsa042600.89760711
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88815588
76Homologous recombination_Homo sapiens_hsa034400.87799281
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85150591
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84162983
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83877531
80Legionellosis_Homo sapiens_hsa051340.81496054
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.80767087
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79619156
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79208350
84Chemical carcinogenesis_Homo sapiens_hsa052040.79093383
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.78836653
86Huntingtons disease_Homo sapiens_hsa050160.78775207
87Oxidative phosphorylation_Homo sapiens_hsa001900.78221570
88Nitrogen metabolism_Homo sapiens_hsa009100.77084735
89Melanoma_Homo sapiens_hsa052180.77027889
90Biosynthesis of amino acids_Homo sapiens_hsa012300.72984047
91Malaria_Homo sapiens_hsa051440.72133477
92Collecting duct acid secretion_Homo sapiens_hsa049660.66151058
93ABC transporters_Homo sapiens_hsa020100.65291848
94Graft-versus-host disease_Homo sapiens_hsa053320.62955354
95Estrogen signaling pathway_Homo sapiens_hsa049150.61363790
96Systemic lupus erythematosus_Homo sapiens_hsa053220.60040286
97Fatty acid elongation_Homo sapiens_hsa000620.58425570
98Thyroid hormone synthesis_Homo sapiens_hsa049180.57672726
99Staphylococcus aureus infection_Homo sapiens_hsa051500.57584674
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57183680
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56783873
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.56229819
103Renin-angiotensin system_Homo sapiens_hsa046140.54918965
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54730025
105Protein digestion and absorption_Homo sapiens_hsa049740.54101498
106Tryptophan metabolism_Homo sapiens_hsa003800.52982587
107Regulation of autophagy_Homo sapiens_hsa041400.52458699
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51890833
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47532034
110Tight junction_Homo sapiens_hsa045300.46885434
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46791093
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.45523258
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.44053220
114Prostate cancer_Homo sapiens_hsa052150.44010439
115Morphine addiction_Homo sapiens_hsa050320.43807274
116Glutamatergic synapse_Homo sapiens_hsa047240.43737672
117Inositol phosphate metabolism_Homo sapiens_hsa005620.43335959
118Type II diabetes mellitus_Homo sapiens_hsa049300.42840039
119MAPK signaling pathway_Homo sapiens_hsa040100.42725719
120TNF signaling pathway_Homo sapiens_hsa046680.41688127
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40713922
122Bile secretion_Homo sapiens_hsa049760.40508284
123Endocytosis_Homo sapiens_hsa041440.40025840
124Calcium signaling pathway_Homo sapiens_hsa040200.37980391
125Basal cell carcinoma_Homo sapiens_hsa052170.36799240
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35483734
127Allograft rejection_Homo sapiens_hsa053300.35240599
128Pancreatic secretion_Homo sapiens_hsa049720.34760199
129AMPK signaling pathway_Homo sapiens_hsa041520.33753075
130VEGF signaling pathway_Homo sapiens_hsa043700.33662729
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33411551
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33271850
133Long-term potentiation_Homo sapiens_hsa047200.32976046
134Insulin secretion_Homo sapiens_hsa049110.32708923
135cAMP signaling pathway_Homo sapiens_hsa040240.32217163
136Long-term depression_Homo sapiens_hsa047300.32003311
137Pyrimidine metabolism_Homo sapiens_hsa002400.31571699
138Metabolic pathways_Homo sapiens_hsa011000.30046218
139RNA degradation_Homo sapiens_hsa030180.29296458
140Vitamin digestion and absorption_Homo sapiens_hsa049770.29190627
141Toxoplasmosis_Homo sapiens_hsa051450.28499256
142B cell receptor signaling pathway_Homo sapiens_hsa046620.27170158
143Salivary secretion_Homo sapiens_hsa049700.24341354
144Sulfur metabolism_Homo sapiens_hsa009200.22635918
145Viral carcinogenesis_Homo sapiens_hsa052030.22571968
146Wnt signaling pathway_Homo sapiens_hsa043100.22559516
147Influenza A_Homo sapiens_hsa051640.21906051
148DNA replication_Homo sapiens_hsa030300.20390851
149Measles_Homo sapiens_hsa051620.18805854
150Sulfur relay system_Homo sapiens_hsa041220.17950932
151Gastric acid secretion_Homo sapiens_hsa049710.16568355
152Cell cycle_Homo sapiens_hsa041100.15961761
153Alcoholism_Homo sapiens_hsa050340.15422336
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.13498014
155Insulin resistance_Homo sapiens_hsa049310.12986665
156Taste transduction_Homo sapiens_hsa047420.12113636
157N-Glycan biosynthesis_Homo sapiens_hsa005100.11905058

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