TULP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)3.99483186
2lateral sprouting from an epithelium (GO:0060601)3.96679078
3protein localization to kinetochore (GO:0034501)3.37095597
4mitotic sister chromatid segregation (GO:0000070)3.33917648
5regulation of timing of cell differentiation (GO:0048505)3.24687971
6sister chromatid segregation (GO:0000819)3.20289742
7regulation of development, heterochronic (GO:0040034)3.14890905
8regulation of nuclear cell cycle DNA replication (GO:0033262)3.10710019
9notochord development (GO:0030903)3.08492113
10metaphase plate congression (GO:0051310)3.07231656
11mitotic chromosome condensation (GO:0007076)3.02069013
12CENP-A containing nucleosome assembly (GO:0034080)3.02032465
13ventricular cardiac muscle cell development (GO:0055015)2.99232885
14protein localization to chromosome, centromeric region (GO:0071459)2.98934227
15chromatin remodeling at centromere (GO:0031055)2.98653276
16regulation of spindle organization (GO:0090224)2.98185874
17centriole assembly (GO:0098534)2.95896941
18protein K6-linked ubiquitination (GO:0085020)2.93549351
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93265613
20piRNA metabolic process (GO:0034587)2.92116561
21regulation of non-canonical Wnt signaling pathway (GO:2000050)2.85538312
22regulation of DNA endoreduplication (GO:0032875)2.85089564
23mesenchymal cell differentiation involved in renal system development (GO:2001012)2.81633461
24mesenchymal cell differentiation involved in kidney development (GO:0072161)2.81633461
25protein localization to chromosome (GO:0034502)2.81558286
26mitotic sister chromatid cohesion (GO:0007064)2.81517284
27female gonad development (GO:0008585)2.78956080
28centriole replication (GO:0007099)2.75074264
29negative regulation of DNA-dependent DNA replication (GO:2000104)2.74967433
30DNA integration (GO:0015074)2.73610189
31metanephric mesenchyme development (GO:0072075)2.73320299
32synapsis (GO:0007129)2.72989361
33replicative senescence (GO:0090399)2.72258479
34attachment of spindle microtubules to kinetochore (GO:0008608)2.68613408
35regulation of acrosome reaction (GO:0060046)2.68440158
36regulation of meiosis I (GO:0060631)2.68292231
37kinetochore assembly (GO:0051382)2.66687263
38histone H2A acetylation (GO:0043968)2.64401294
39establishment of chromosome localization (GO:0051303)2.63695944
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.62813827
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.62813827
42positive regulation of mitotic sister chromatid separation (GO:1901970)2.62813827
43meiotic cell cycle (GO:0051321)2.62066919
44cell proliferation in forebrain (GO:0021846)2.60331279
45microtubule depolymerization (GO:0007019)2.56905405
46extracellular negative regulation of signal transduction (GO:1900116)2.55891136
47extracellular regulation of signal transduction (GO:1900115)2.55891136
48regulation of mitotic spindle organization (GO:0060236)2.55726533
49establishment of integrated proviral latency (GO:0075713)2.54659315
50maturation of 5.8S rRNA (GO:0000460)2.52416493
51negative regulation of chondrocyte differentiation (GO:0032331)2.50586792
52kidney mesenchyme development (GO:0072074)2.49111368
53myoblast migration (GO:0051451)2.48592839
54DNA unwinding involved in DNA replication (GO:0006268)2.48218451
55proteasome assembly (GO:0043248)2.48172277
56positive regulation of chromosome segregation (GO:0051984)2.48005641
57planar cell polarity pathway involved in neural tube closure (GO:0090179)2.47785090
58bone trabecula formation (GO:0060346)2.46579257
59histone exchange (GO:0043486)2.46515119
60DNA replication checkpoint (GO:0000076)2.45416947
61negative regulation of keratinocyte proliferation (GO:0010839)2.45335666
62regulation of glomerulus development (GO:0090192)2.44910026
63regulation of mesoderm development (GO:2000380)2.42991616
64outer ear morphogenesis (GO:0042473)2.42105138
65bone remodeling (GO:0046849)2.37749281
66kinetochore organization (GO:0051383)2.37394567
67mesenchymal-epithelial cell signaling (GO:0060638)2.35269793
68mitotic spindle organization (GO:0007052)2.33809919
69meiotic chromosome segregation (GO:0045132)2.33461115
70spindle checkpoint (GO:0031577)2.33345004
71embryonic cranial skeleton morphogenesis (GO:0048701)2.32372181
72kidney morphogenesis (GO:0060993)2.31933967
73response to X-ray (GO:0010165)2.31691559
74regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31552478
75chromosome organization involved in meiosis (GO:0070192)2.30301078
76hippo signaling (GO:0035329)2.29447329
77negative regulation of myoblast differentiation (GO:0045662)2.28357203
78DNA strand elongation involved in DNA replication (GO:0006271)2.26720197
79regulation of keratinocyte proliferation (GO:0010837)2.26246524
80middle ear morphogenesis (GO:0042474)2.25742920
81cell differentiation involved in metanephros development (GO:0072202)2.25638194
82cranial nerve morphogenesis (GO:0021602)2.25631409
83positive regulation of gastrulation (GO:2000543)2.25630148
84DNA strand elongation (GO:0022616)2.25409079
85mesonephros development (GO:0001823)2.25360590
86regulation of helicase activity (GO:0051095)2.25176306
87nonmotile primary cilium assembly (GO:0035058)2.24933518
88regulation of male gonad development (GO:2000018)2.24107438
89daunorubicin metabolic process (GO:0044597)2.23228650
90polyketide metabolic process (GO:0030638)2.23228650
91doxorubicin metabolic process (GO:0044598)2.23228650
92L-serine metabolic process (GO:0006563)2.22886119
93retinal cone cell development (GO:0046549)2.22711587
94somatic stem cell division (GO:0048103)2.22113305
95DNA replication-independent nucleosome assembly (GO:0006336)2.21768012
96DNA replication-independent nucleosome organization (GO:0034724)2.21768012
97regulation of chromosome segregation (GO:0051983)2.20841778
98glomerulus development (GO:0032835)2.20555634
99regulation of gene silencing by RNA (GO:0060966)2.19785341
100regulation of posttranscriptional gene silencing (GO:0060147)2.19785341
101regulation of gene silencing by miRNA (GO:0060964)2.19785341
102resolution of meiotic recombination intermediates (GO:0000712)2.19626111
103mesenchymal cell differentiation (GO:0048762)2.19064013
104limb bud formation (GO:0060174)2.18495950
105positive regulation of DNA-dependent DNA replication (GO:2000105)2.17622903
106fibroblast migration (GO:0010761)2.17507131
107spindle assembly involved in mitosis (GO:0090307)2.17119667
108cranial suture morphogenesis (GO:0060363)2.16356298
109regulation of cilium movement (GO:0003352)2.15795568
110specification of organ identity (GO:0010092)2.15423133
111mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.15385157
112* embryonic digit morphogenesis (GO:0042733)2.15366803
113mitotic metaphase plate congression (GO:0007080)2.15134987
114epithelial cilium movement (GO:0003351)2.14952700
115DNA methylation involved in gamete generation (GO:0043046)2.14628458
116cellular response to gamma radiation (GO:0071480)2.14497892
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.14202902
118chondrocyte proliferation (GO:0035988)2.13884894
119cochlea morphogenesis (GO:0090103)2.13839009
120craniofacial suture morphogenesis (GO:0097094)2.13751991
121epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.13671911
122embryonic foregut morphogenesis (GO:0048617)2.13469978
123developmental pigmentation (GO:0048066)2.13458414
124preassembly of GPI anchor in ER membrane (GO:0016254)2.13382174
125regulation of DNA methylation (GO:0044030)2.13034702
126somite development (GO:0061053)2.13033423
127regulation of centrosome cycle (GO:0046605)2.12825359
128negative regulation of androgen receptor signaling pathway (GO:0060766)2.12660459
129chromosome segregation (GO:0007059)2.12153208
130regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.11913451
131Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.11079567
132cell fate commitment involved in formation of primary germ layer (GO:0060795)2.10834438
133regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.10563579
134retinal ganglion cell axon guidance (GO:0031290)2.10093269
135type B pancreatic cell proliferation (GO:0044342)2.09388247
136binding of sperm to zona pellucida (GO:0007339)2.09051561
137regulation of somitogenesis (GO:0014807)2.08480222
138sequestering of extracellular ligand from receptor (GO:0035581)2.08223321
139regulation of integrin-mediated signaling pathway (GO:2001044)2.07672773
140regulation of centriole replication (GO:0046599)2.07348249
141urogenital system development (GO:0001655)2.06846653
142negative regulation of leukocyte chemotaxis (GO:0002689)2.06810452
143establishment of skin barrier (GO:0061436)2.06682258
144regulation of cell proliferation involved in kidney development (GO:1901722)2.06599481
145cilium morphogenesis (GO:0060271)2.06185859
146regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.05632451
147presynaptic membrane assembly (GO:0097105)2.05632300
148cullin deneddylation (GO:0010388)2.05253436
149neural crest cell development (GO:0014032)2.04810932
150mitotic spindle checkpoint (GO:0071174)2.04597795
151synaptonemal complex assembly (GO:0007130)2.04311586
152telomere maintenance via telomerase (GO:0007004)2.03997114
153G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.03892171
154negative regulation of osteoblast proliferation (GO:0033689)2.03820474
155regulation of telomere maintenance via telomerase (GO:0032210)2.03209119
156non-canonical Wnt signaling pathway (GO:0035567)2.02959264
157regulation of establishment of planar polarity (GO:0090175)2.02794738
158radial glial cell differentiation (GO:0060019)2.02654619
159DNA synthesis involved in DNA repair (GO:0000731)2.02385684
160regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.02378305
161regulation of mitotic metaphase/anaphase transition (GO:0030071)2.02378305
162embryonic forelimb morphogenesis (GO:0035115)2.02374079
163tongue development (GO:0043586)2.02071760
164protein polyglutamylation (GO:0018095)2.01870392
165maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.01847057
166convergent extension (GO:0060026)2.01449765
167sister chromatid cohesion (GO:0007062)2.01253556
168establishment of planar polarity (GO:0001736)2.01137372
169establishment of tissue polarity (GO:0007164)2.01137372
170intraciliary transport (GO:0042073)2.00833933
171single strand break repair (GO:0000012)2.00797227
172histone H4-K12 acetylation (GO:0043983)2.00391208
173head development (GO:0060322)1.99883398
174DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla1.99021590
175DNA double-strand break processing (GO:0000729)1.98473442
176axon extension involved in axon guidance (GO:0048846)1.98292974
177neuron projection extension involved in neuron projection guidance (GO:1902284)1.98292974
178DNA damage response, detection of DNA damage (GO:0042769)1.98232898
179regulation of mitotic sister chromatid segregation (GO:0033047)1.97900629
180regulation of sister chromatid segregation (GO:0033045)1.97900629
181regulation of mitotic sister chromatid separation (GO:0010965)1.97900629
182retina vasculature morphogenesis in camera-type eye (GO:0061299)1.97487582
183DNA replication-dependent nucleosome organization (GO:0034723)1.96642984
184DNA replication-dependent nucleosome assembly (GO:0006335)1.96642984
185cerebral cortex radially oriented cell migration (GO:0021799)1.95479354
186replication fork processing (GO:0031297)1.95032389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_19390658_ChIP-ChIP_HaCaT_Human3.07310223
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71170897
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.59525015
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51675523
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51675523
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51675523
7AR_21909140_ChIP-Seq_LNCAP_Human2.41598151
8E2F7_22180533_ChIP-Seq_HELA_Human2.31679133
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.29950705
10GBX2_23144817_ChIP-Seq_PC3_Human2.27814255
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23331155
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20405887
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13369391
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10998596
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03390840
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99035731
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.95529255
18ZNF274_21170338_ChIP-Seq_K562_Hela1.91025577
19FUS_26573619_Chip-Seq_HEK293_Human1.88736802
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88558959
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86317359
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.86270761
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85216811
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.81026561
25ELK1_19687146_ChIP-ChIP_HELA_Human1.78466895
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77987284
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74845286
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.72370601
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.71072710
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70274171
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68838080
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66098931
33EWS_26573619_Chip-Seq_HEK293_Human1.64501966
34RNF2_27304074_Chip-Seq_NSC_Mouse1.61385509
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.59285503
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.56793324
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56402335
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54487743
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53910738
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52444044
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.51532357
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.50417889
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50070095
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44883972
45EZH2_22144423_ChIP-Seq_EOC_Human1.43356903
46IGF1R_20145208_ChIP-Seq_DFB_Human1.43308705
47* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42121591
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39591480
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38995093
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37699856
51* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37196942
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.37154534
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37013214
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36538087
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34989532
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34470430
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34453451
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34123031
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.33804947
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.32349812
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31693330
62* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31522074
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.31230233
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.30997556
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30817618
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30539719
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29936917
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29254743
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29164096
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28986765
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28847339
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28222931
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.26500648
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25565432
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23712722
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23444480
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.22992078
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22775770
79* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22407417
80CJUN_26792858_Chip-Seq_BT549_Human1.20843951
81BRD4_25478319_ChIP-Seq_HGPS_Human1.20653674
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20241059
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.20142461
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19259957
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.18131095
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18098058
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17971677
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17696522
89SOX9_26525672_Chip-Seq_HEART_Mouse1.17687620
90LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17547046
91SMAD4_21799915_ChIP-Seq_A2780_Human1.17521379
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17127831
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16993776
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14819984
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.14624174
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.14480410
97P300_19829295_ChIP-Seq_ESCs_Human1.13468665
98P300_18555785_Chip-Seq_ESCs_Mouse1.13175236
99P53_22387025_ChIP-Seq_ESCs_Mouse1.13154057
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.13105167
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12889730
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.12082281
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.11298069
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09841069
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09442568
106TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08722245
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08332940
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08332940
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07978552
110TP53_18474530_ChIP-ChIP_U2OS_Human1.07836658
111TP53_20018659_ChIP-ChIP_R1E_Mouse1.07581283
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07024241
113ZFX_18555785_Chip-Seq_ESCs_Mouse1.06486669
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.06350353
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06228430
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05844057
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.05610913
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.04367312
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03844906
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03767667
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01579279
122IRF1_19129219_ChIP-ChIP_H3396_Human1.01358867
123TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01165287
124SOX17_20123909_ChIP-Seq_XEN_Mouse1.00900260
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00201727
126FOXM1_23109430_ChIP-Seq_U2OS_Human1.00164931
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98807467
128MYC_18555785_ChIP-Seq_MESCs_Mouse0.98597223
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98207141
130RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98176294
131EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98176294
132JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97136680
133DCP1A_22483619_ChIP-Seq_HELA_Human0.96949766
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96246172
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95980810
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.95833584
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.95744374
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95719998
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95367545
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95185071
141ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94658607
142NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94574216
143JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94470310
144FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93751584
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93573411
146KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93204522
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91678582
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90490768
149MYC_18940864_ChIP-ChIP_HL60_Human0.90463567
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88482489
151FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87888356
152AR_25329375_ChIP-Seq_VCAP_Human0.85703983
153MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85538616
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85318533
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84943425
156MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84874738
157* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84869251
158VDR_22108803_ChIP-Seq_LS180_Human0.84705053
159GATA1_26923725_Chip-Seq_HPCs_Mouse0.84247324
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83769910
161ETS1_20019798_ChIP-Seq_JURKAT_Human0.83268964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.59344479
2MP0000566_synostosis3.39580921
3MP0005171_absent_coat_pigmentation3.05390388
4MP0003136_yellow_coat_color2.83857057
5MP0006292_abnormal_olfactory_placode2.82423696
6MP0010030_abnormal_orbit_morphology2.58044406
7MP0003878_abnormal_ear_physiology2.17679288
8MP0005377_hearing/vestibular/ear_phenot2.17679288
9MP0005499_abnormal_olfactory_system2.12803659
10MP0005394_taste/olfaction_phenotype2.12803659
11MP0005503_abnormal_tendon_morphology2.07982501
12MP0000049_abnormal_middle_ear2.06378487
13MP0001188_hyperpigmentation1.97140846
14MP0010368_abnormal_lymphatic_system1.93101247
15MP0002938_white_spotting1.90878234
16MP0002249_abnormal_larynx_morphology1.85339011
17MP0003937_abnormal_limbs/digits/tail_de1.81669721
18MP0000372_irregular_coat_pigmentation1.70185018
19MP0001485_abnormal_pinna_reflex1.67252023
20MP0009250_abnormal_appendicular_skeleto1.65449637
21MP0001346_abnormal_lacrimal_gland1.60701270
22MP0005257_abnormal_intraocular_pressure1.59849197
23MP0003755_abnormal_palate_morphology1.54198674
24MP0008058_abnormal_DNA_repair1.53802885
25MP0002277_abnormal_respiratory_mucosa1.50531605
26MP0006054_spinal_hemorrhage1.49663563
27MP0000762_abnormal_tongue_morphology1.47622983
28MP0002234_abnormal_pharynx_morphology1.46202930
29MP0009780_abnormal_chondrocyte_physiolo1.45524935
30MP0008057_abnormal_DNA_replication1.44705338
31MP0001293_anophthalmia1.44373391
32MP0004133_heterotaxia1.43300661
33MP0005508_abnormal_skeleton_morphology1.42578361
34MP0002233_abnormal_nose_morphology1.40463100
35MP0003111_abnormal_nucleus_morphology1.39918578
36MP0008438_abnormal_cutaneous_collagen1.38139828
37MP0010094_abnormal_chromosome_stability1.38123553
38MP0002116_abnormal_craniofacial_bone1.36426473
39MP0003942_abnormal_urinary_system1.35574562
40MP0005623_abnormal_meninges_morphology1.35439426
41* MP0000432_abnormal_head_morphology1.35147699
42MP0003938_abnormal_ear_development1.34866636
43MP0002102_abnormal_ear_morphology1.33163356
44MP0000749_muscle_degeneration1.29263084
45MP0003385_abnormal_body_wall1.27774326
46MP0008007_abnormal_cellular_replicative1.26044879
47MP0004381_abnormal_hair_follicle1.25075011
48MP0002932_abnormal_joint_morphology1.24595394
49MP0000428_abnormal_craniofacial_morphol1.24328365
50MP0000026_abnormal_inner_ear1.23057674
51MP0002177_abnormal_outer_ear1.21549541
52MP0001986_abnormal_taste_sensitivity1.19785313
53MP0002282_abnormal_trachea_morphology1.15759455
54MP0004957_abnormal_blastocyst_morpholog1.13145207
55MP0001879_abnormal_lymphatic_vessel1.12671015
56MP0003950_abnormal_plasma_membrane1.12487681
57* MP0001286_abnormal_eye_development1.12429574
58MP0005367_renal/urinary_system_phenotyp1.12169155
59MP0000516_abnormal_urinary_system1.12169155
60MP0008789_abnormal_olfactory_epithelium1.10184184
61MP0009384_cardiac_valve_regurgitation1.09929719
62MP0003786_premature_aging1.09900902
63MP0003890_abnormal_embryonic-extraembry1.08513544
64MP0002084_abnormal_developmental_patter1.08199375
65MP0001984_abnormal_olfaction1.08033399
66MP0005275_abnormal_skin_tensile1.07332487
67MP0008932_abnormal_embryonic_tissue1.06221254
68MP0003121_genomic_imprinting1.05488661
69* MP0002085_abnormal_embryonic_tissue1.05451864
70MP0005248_abnormal_Harderian_gland1.05273462
71MP0003119_abnormal_digestive_system1.04969064
72MP0000647_abnormal_sebaceous_gland1.04934653
73MP0004272_abnormal_basement_membrane1.04258938
74MP0000678_abnormal_parathyroid_gland1.04016045
75MP0005395_other_phenotype1.02908919
76MP0003718_maternal_effect1.02832772
77MP0003787_abnormal_imprinting1.02303791
78MP0000631_abnormal_neuroendocrine_gland1.01544941
79MP0002111_abnormal_tail_morphology1.01495652
80MP0000613_abnormal_salivary_gland1.00054077
81MP0004885_abnormal_endolymph0.98552186
82* MP0002109_abnormal_limb_morphology0.98356919
83MP0002653_abnormal_ependyma_morphology0.95854993
84* MP0002114_abnormal_axial_skeleton0.95852977
85MP0003279_aneurysm0.95512566
86MP0003077_abnormal_cell_cycle0.95479747
87MP0005409_darkened_coat_color0.95132834
88* MP0003935_abnormal_craniofacial_develop0.94971425
89MP0003186_abnormal_redox_activity0.94058783
90MP0000537_abnormal_urethra_morphology0.94015381
91MP0003693_abnormal_embryo_hatching0.92700172
92MP0002108_abnormal_muscle_morphology0.92611680
93MP0005646_abnormal_pituitary_gland0.92225406
94MP0002163_abnormal_gland_morphology0.91223651
95MP0000383_abnormal_hair_follicle0.90575941
96MP0002697_abnormal_eye_size0.90370277
97MP0008995_early_reproductive_senescence0.89874449
98MP0004233_abnormal_muscle_weight0.89316153
99MP0001186_pigmentation_phenotype0.89246770
100MP0001929_abnormal_gametogenesis0.88560519
101MP0005408_hypopigmentation0.87986196
102* MP0003861_abnormal_nervous_system0.87536225
103MP0000534_abnormal_ureter_morphology0.86583635
104MP0002751_abnormal_autonomic_nervous0.85867730
105MP0000778_abnormal_nervous_system0.85237105
106MP0003936_abnormal_reproductive_system0.83826213
107MP0003705_abnormal_hypodermis_morpholog0.82980792
108MP0001963_abnormal_hearing_physiology0.82826471
109MP0008877_abnormal_DNA_methylation0.81869838
110MP0003315_abnormal_perineum_morphology0.81833534
111MP0000653_abnormal_sex_gland0.81316116
112MP0005380_embryogenesis_phenotype0.81309614
113MP0001672_abnormal_embryogenesis/_devel0.81309614
114MP0000427_abnormal_hair_cycle0.81214769
115MP0000579_abnormal_nail_morphology0.80317966
116MP0002095_abnormal_skin_pigmentation0.80098324
117MP0001299_abnormal_eye_distance/0.79983543
118MP0000163_abnormal_cartilage_morphology0.79884183
119MP0002210_abnormal_sex_determination0.79674049
120MP0004742_abnormal_vestibular_system0.79549048
121MP0006072_abnormal_retinal_apoptosis0.79340130
122MP0002098_abnormal_vibrissa_morphology0.78934366
123MP0002075_abnormal_coat/hair_pigmentati0.78731742
124MP0005197_abnormal_uvea_morphology0.78439988
125MP0002160_abnormal_reproductive_system0.78301438
126MP0002295_abnormal_pulmonary_circulatio0.78112638
127MP0000569_abnormal_digit_pigmentation0.77667642
128MP0005187_abnormal_penis_morphology0.77652904
129MP0000015_abnormal_ear_pigmentation0.77006913
130MP0001119_abnormal_female_reproductive0.76996695
131MP0001542_abnormal_bone_strength0.75827063
132MP0010678_abnormal_skin_adnexa0.74910415
133MP0010234_abnormal_vibrissa_follicle0.74098610
134MP0005253_abnormal_eye_physiology0.73812302
135MP0001697_abnormal_embryo_size0.73736911
136MP0005391_vision/eye_phenotype0.72967013

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.66257021
2Chromsome breakage (HP:0040012)3.38267953
3Abnormality of the renal collecting system (HP:0004742)2.69922361
4Ankle contracture (HP:0006466)2.64059229
5Duplicated collecting system (HP:0000081)2.63989841
6Popliteal pterygium (HP:0009756)2.57599828
7Abnormality of dentin (HP:0010299)2.53891497
8Septo-optic dysplasia (HP:0100842)2.47290864
9Soft skin (HP:0000977)2.47068903
10Shallow orbits (HP:0000586)2.43449073
11Morphological abnormality of the middle ear (HP:0008609)2.35973244
12Ectopic kidney (HP:0000086)2.30443169
13Abnormality of the nasal septum (HP:0000419)2.28697932
14Abnormality of cochlea (HP:0000375)2.28597607
15Aplasia of the phalanges of the hand (HP:0009802)2.27246110
16Aplasia involving bones of the extremities (HP:0009825)2.27246110
17Aplasia involving bones of the upper limbs (HP:0009823)2.27246110
18Aplasia/Hypoplasia of the tongue (HP:0010295)2.25203121
19True hermaphroditism (HP:0010459)2.23222626
20Microglossia (HP:0000171)2.22418515
21Abnormality of incisor morphology (HP:0011063)2.18434690
22Bifid tongue (HP:0010297)2.13681428
23Bell-shaped thorax (HP:0001591)2.12578955
24Median cleft lip (HP:0000161)2.10804233
25Cutaneous finger syndactyly (HP:0010554)2.09008127
26Cutaneous syndactyly (HP:0012725)2.06613117
27Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05992014
28Selective tooth agenesis (HP:0001592)2.05150825
29Fibular aplasia (HP:0002990)2.04941906
30Supernumerary spleens (HP:0009799)2.04516199
31Short tibia (HP:0005736)2.04107407
32Protrusio acetabuli (HP:0003179)2.03456214
33Lip pit (HP:0100267)2.03261639
34Tubulointerstitial nephritis (HP:0001970)2.01876585
35Meckel diverticulum (HP:0002245)2.01580525
36Absent forearm bone (HP:0003953)2.01579576
37Aplasia involving forearm bones (HP:0009822)2.01579576
38Morphological abnormality of the inner ear (HP:0011390)2.01077632
39Preaxial hand polydactyly (HP:0001177)1.98683754
40Aplasia of the musculature (HP:0100854)1.98605593
41Abnormality of the columella (HP:0009929)1.97943230
42Increased nuchal translucency (HP:0010880)1.97640407
43Absent radius (HP:0003974)1.97301658
44Pancreatic fibrosis (HP:0100732)1.97024358
45Short middle phalanx of the 5th finger (HP:0004220)1.96796969
46Abnormal lung lobation (HP:0002101)1.96241370
47Abnormality of the ileum (HP:0001549)1.94261794
48Congenital primary aphakia (HP:0007707)1.94214897
49White forelock (HP:0002211)1.93758408
50Adrenal hypoplasia (HP:0000835)1.93365514
51Abnormality of midbrain morphology (HP:0002418)1.92312043
52Molar tooth sign on MRI (HP:0002419)1.92312043
53Abnormality of the incisor (HP:0000676)1.91942198
54Aplasia/Hypoplasia of the uvula (HP:0010293)1.90491842
55Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90163511
56Neonatal short-limb short stature (HP:0008921)1.89688712
57Medial flaring of the eyebrow (HP:0010747)1.89338116
58Abnormal ciliary motility (HP:0012262)1.89041716
59Facial cleft (HP:0002006)1.86743305
60Pancreatic cysts (HP:0001737)1.86242955
61Abnormality of the parietal bone (HP:0002696)1.86197557
62Abnormality of molar (HP:0011077)1.86028192
63Abnormality of molar morphology (HP:0011070)1.86028192
64Aplasia cutis congenita (HP:0001057)1.85628142
65Nasolacrimal duct obstruction (HP:0000579)1.85457816
66Abnormality of the preputium (HP:0100587)1.85384892
67Patchy hypopigmentation of hair (HP:0011365)1.84802269
68Synostosis of carpal bones (HP:0005048)1.83363333
69Gait imbalance (HP:0002141)1.82599415
70Wrist flexion contracture (HP:0001239)1.82502425
71Absent septum pellucidum (HP:0001331)1.81610710
72Abnormality of the lacrimal duct (HP:0011481)1.81603340
73Abnormality of the nasolacrimal system (HP:0000614)1.81566372
74Aplasia/Hypoplasia of the fovea (HP:0008060)1.81555828
75Hypoplasia of the fovea (HP:0007750)1.81555828
76Facial hemangioma (HP:0000329)1.81158599
77Oligodactyly (hands) (HP:0001180)1.80538598
78Duplication of thumb phalanx (HP:0009942)1.76873253
79Abnormality of the phalanges of the 5th finger (HP:0004213)1.76766187
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.76562712
81Abnormality of the middle phalanges of the toes (HP:0010183)1.76437144
82Genital tract atresia (HP:0001827)1.76213960
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75894297
84Absent epiphyses (HP:0010577)1.75894297
85Optic nerve hypoplasia (HP:0000609)1.75336591
86Follicular hyperkeratosis (HP:0007502)1.74863240
87Pterygium (HP:0001059)1.74729215
88Abnormality of the labia minora (HP:0012880)1.73907308
89Abnormality of secondary sexual hair (HP:0009888)1.73853360
90Abnormality of the axillary hair (HP:0100134)1.73853360
91Sex reversal (HP:0012245)1.73835939
92Abnormal sex determination (HP:0012244)1.73835939
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73550028
94Nephrogenic diabetes insipidus (HP:0009806)1.73427102
95Supernumerary bones of the axial skeleton (HP:0009144)1.73416588
96Osteomalacia (HP:0002749)1.73143603
97Conical tooth (HP:0000698)1.72798737
98Calcaneovalgus deformity (HP:0001848)1.72198635
99Oligodactyly (HP:0012165)1.71947898
100Patellar aplasia (HP:0006443)1.71795889
101Abnormality of the dental root (HP:0006486)1.71555452
102Taurodontia (HP:0000679)1.71555452
103Abnormality of permanent molar morphology (HP:0011071)1.71555452
104Rib fusion (HP:0000902)1.71527811
105Occipital encephalocele (HP:0002085)1.70720923
106Abnormality of the septum pellucidum (HP:0007375)1.70264728
107Postaxial foot polydactyly (HP:0001830)1.70195474
108Abnormal number of incisors (HP:0011064)1.69237851
109Volvulus (HP:0002580)1.67720370
110Clubbing of toes (HP:0100760)1.67337257
111Abnormality of the proximal phalanges of the hand (HP:0009834)1.64894703
112Abnormal respiratory motile cilium physiology (HP:0012261)1.63996914
113Long nose (HP:0003189)1.63640461
114Vascular tortuosity (HP:0004948)1.63629168
115Supernumerary ribs (HP:0005815)1.63532756
116Mesomelia (HP:0003027)1.63258490
117Abnormality of the labia (HP:0000058)1.62319363
118Abdominal situs inversus (HP:0003363)1.62264825
119Abnormality of abdominal situs (HP:0011620)1.62264825
120Congenital sensorineural hearing impairment (HP:0008527)1.61864760
121Mixed hearing impairment (HP:0000410)1.61602103
122Cortical dysplasia (HP:0002539)1.60951892
123Small intestinal stenosis (HP:0012848)1.60587138
124Duodenal stenosis (HP:0100867)1.60587138
125Postaxial hand polydactyly (HP:0001162)1.60316535
126Aplasia/Hypoplasia of the patella (HP:0006498)1.59684276
127Intestinal atresia (HP:0011100)1.59665944
128Vaginal atresia (HP:0000148)1.59606989
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59224647
130Abnormality of the dental pulp (HP:0006479)1.58952880
131Onycholysis (HP:0001806)1.58898847
132Nephroblastoma (Wilms tumor) (HP:0002667)1.58739301
133Rhinitis (HP:0012384)1.58735716
134Hypoplastic labia majora (HP:0000059)1.56920953
135Broad foot (HP:0001769)1.56420618
136Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.55968933
137Premature rupture of membranes (HP:0001788)1.55623553
138Synostosis involving the elbow (HP:0003938)1.55120605
139Humeroradial synostosis (HP:0003041)1.55120605
140Deformed tarsal bones (HP:0008119)1.55040103
141Embryonal renal neoplasm (HP:0011794)1.54905753
142Triphalangeal thumb (HP:0001199)1.54808811
143Carpal synostosis (HP:0009702)1.54780865
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.54714337
145Limited hip movement (HP:0008800)1.53836868
146Carpal bone hypoplasia (HP:0001498)1.53470820
147Breech presentation (HP:0001623)1.53011502
148Coronal craniosynostosis (HP:0004440)1.52042986
149Aortic dissection (HP:0002647)1.51501628
150Abnormality of chromosome stability (HP:0003220)1.51282372
151Astigmatism (HP:0000483)1.49894630
152Small epiphyses (HP:0010585)1.48891120
153Abnormality of the duodenum (HP:0002246)1.48018946
154Abnormality of the labia majora (HP:0012881)1.46032026
155Nephronophthisis (HP:0000090)1.45081816
156Hypoplastic female external genitalia (HP:0012815)1.42887413
157Arterial tortuosity (HP:0005116)1.42877850
158Hydroureter (HP:0000072)1.42477789
159Dandy-Walker malformation (HP:0001305)1.42163874
160Retinal dysplasia (HP:0007973)1.40799753
161Abnormal respiratory epithelium morphology (HP:0012253)1.40777874
162Abnormal respiratory motile cilium morphology (HP:0005938)1.40777874
163Spinal rigidity (HP:0003306)1.40337830
164Dental crowding (HP:0000678)1.40226131
165Delayed gross motor development (HP:0002194)1.40036201
166Abnormality of the fovea (HP:0000493)1.38717162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.65909281
2MUSK3.40404990
3ZAK3.36839151
4STK38L3.26323110
5PLK42.89044444
6IRAK32.56809577
7SRPK12.52871833
8MKNK22.49822609
9EPHA22.35763976
10NEK12.16923562
11MKNK12.16216038
12TRIM282.14771001
13LATS22.07310010
14PRPF4B2.01742146
15EIF2AK11.94101319
16CASK1.92666253
17BRD41.92477222
18NEK61.80698572
19TTK1.74775180
20CDK121.67915425
21TNIK1.65735231
22MAP4K21.61280978
23VRK21.60454834
24LIMK11.53754295
25DDR21.52759168
26BRSK21.52471799
27STK161.50473519
28IRAK21.49626605
29BUB11.49277372
30EIF2AK21.47958118
31IRAK11.47062016
32BRSK11.46290364
33WNK31.44104805
34BMPR1B1.42592634
35CHEK21.42212900
36CDC71.39005727
37PTK21.38144246
38CDK81.37691296
39CDK71.32744674
40VRK11.32717689
41STK31.28842155
42IRAK41.26946915
43TLK11.25321840
44FGFR21.25239821
45EPHA31.23131095
46MST41.15518327
47AKT31.14545596
48CDK31.14349343
49NEK21.14118009
50PLK31.13530056
51YES11.13247554
52MAP3K121.10598626
53BMPR21.09917391
54ATR1.08910276
55CCNB11.07169340
56MYLK1.06380802
57TGFBR11.04050506
58PRKD21.03562454
59NUAK11.02846655
60DYRK21.01461074
61TSSK61.00917425
62TIE10.98022466
63PLK10.95986615
64FRK0.90291425
65PAK40.89645225
66ERBB30.88496240
67PDGFRA0.88429721
68DMPK0.87390653
69MAPK130.85355985
70EPHA40.84827159
71ADRBK20.84776639
72PNCK0.83541796
73ATM0.82356658
74MELK0.79799122
75NLK0.76922544
76CSNK1G30.75715015
77CDC42BPA0.75150310
78FER0.73330549
79TAF10.71322156
80STK40.70840572
81PLK20.70111308
82PAK30.69106782
83CSNK1G20.68712192
84BCR0.67667498
85RPS6KA50.66615155
86CHEK10.66359898
87CLK10.63896978
88SIK30.63473100
89PRKCE0.62466639
90GRK10.62264184
91AURKB0.62234792
92TRPM70.61674970
93LMTK20.61072984
94MAPK150.60627455
95INSRR0.58334557
96EPHB20.57762915
97CDK90.57420866
98PRKCI0.56343822
99WEE10.55547769
100SGK20.55408961
101TESK10.55383280
102AURKA0.55123426
103FGFR10.54161237
104MAPK70.51389020
105DYRK30.51232452
106MINK10.50818063
107ILK0.49971261
108PASK0.47870203
109MET0.45877875
110STK380.45822717
111BRAF0.45552164
112CDK10.45530714
113ERBB40.44819788
114TAOK20.44170611
115ROCK10.43395570
116NTRK10.42523872
117MAPKAPK30.42397125
118STK390.42199791
119PBK0.42086823
120CSNK1G10.41103447
121PAK20.40624595
122CHUK0.40515190
123PRKDC0.40450884
124CDK20.40350915
125GSK3B0.39082563
126ROCK20.38981341
127EIF2AK30.38904679
128RPS6KB20.37912556
129AKT10.37746662
130MAPK140.37394597
131MARK10.36724468
132CSNK1A1L0.35290532
133OXSR10.34269613
134WNK10.34086767
135NTRK30.32526350
136CSNK1A10.30647457
137IKBKB0.29203978

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.79652935
2RNA polymerase_Homo sapiens_hsa030202.41713163
3Homologous recombination_Homo sapiens_hsa034402.31946454
4Mismatch repair_Homo sapiens_hsa034302.17278906
5Basal transcription factors_Homo sapiens_hsa030222.13301435
6Basal cell carcinoma_Homo sapiens_hsa052172.05006809
7Non-homologous end-joining_Homo sapiens_hsa034502.03438014
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95287402
9DNA replication_Homo sapiens_hsa030301.92181432
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86939218
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85937328
12Nucleotide excision repair_Homo sapiens_hsa034201.81827641
13Spliceosome_Homo sapiens_hsa030401.73252685
14Cell cycle_Homo sapiens_hsa041101.69960003
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69579197
16Fatty acid elongation_Homo sapiens_hsa000621.65989645
17Hedgehog signaling pathway_Homo sapiens_hsa043401.64495639
18RNA degradation_Homo sapiens_hsa030181.57255518
19p53 signaling pathway_Homo sapiens_hsa041151.55015683
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50985038
21Propanoate metabolism_Homo sapiens_hsa006401.46432306
22Base excision repair_Homo sapiens_hsa034101.44224915
23Hippo signaling pathway_Homo sapiens_hsa043901.43953108
24Sphingolipid metabolism_Homo sapiens_hsa006001.39761856
25mRNA surveillance pathway_Homo sapiens_hsa030151.36460038
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36054684
27Oocyte meiosis_Homo sapiens_hsa041141.34427730
28RNA transport_Homo sapiens_hsa030131.34265439
29ECM-receptor interaction_Homo sapiens_hsa045121.32011932
30Pyrimidine metabolism_Homo sapiens_hsa002401.28149478
31Wnt signaling pathway_Homo sapiens_hsa043101.27566953
32TGF-beta signaling pathway_Homo sapiens_hsa043501.27020136
33Ribosome_Homo sapiens_hsa030101.26196378
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24883171
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.23824401
36Folate biosynthesis_Homo sapiens_hsa007901.21896792
37Notch signaling pathway_Homo sapiens_hsa043301.17652751
38Arachidonic acid metabolism_Homo sapiens_hsa005901.16644724
39MicroRNAs in cancer_Homo sapiens_hsa052061.09685350
40Lysine degradation_Homo sapiens_hsa003101.08757941
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07120587
42Melanoma_Homo sapiens_hsa052181.05157053
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04783620
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04432421
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04001023
46Ether lipid metabolism_Homo sapiens_hsa005651.03866182
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02559520
48Selenocompound metabolism_Homo sapiens_hsa004500.97074466
49Phototransduction_Homo sapiens_hsa047440.96816176
50Protein export_Homo sapiens_hsa030600.96580495
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95205845
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95053645
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94217859
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93702463
55Purine metabolism_Homo sapiens_hsa002300.92436211
56Pyruvate metabolism_Homo sapiens_hsa006200.92379561
57Adherens junction_Homo sapiens_hsa045200.89604549
58Axon guidance_Homo sapiens_hsa043600.89096496
59One carbon pool by folate_Homo sapiens_hsa006700.88640339
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86917463
61Taste transduction_Homo sapiens_hsa047420.86889381
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86595948
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86283782
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85243527
65Small cell lung cancer_Homo sapiens_hsa052220.84829167
66Autoimmune thyroid disease_Homo sapiens_hsa053200.83604004
67Vitamin B6 metabolism_Homo sapiens_hsa007500.82598024
68Pathways in cancer_Homo sapiens_hsa052000.81403346
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80040690
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78254269
71Glutathione metabolism_Homo sapiens_hsa004800.77069644
72Circadian rhythm_Homo sapiens_hsa047100.74406489
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73863304
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73441693
75Prostate cancer_Homo sapiens_hsa052150.73291845
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72852306
77Protein digestion and absorption_Homo sapiens_hsa049740.71666697
78Melanogenesis_Homo sapiens_hsa049160.69906107
79HTLV-I infection_Homo sapiens_hsa051660.69834087
80Ovarian steroidogenesis_Homo sapiens_hsa049130.69466356
81N-Glycan biosynthesis_Homo sapiens_hsa005100.68305373
82Herpes simplex infection_Homo sapiens_hsa051680.67305151
83Linoleic acid metabolism_Homo sapiens_hsa005910.65711573
84Tight junction_Homo sapiens_hsa045300.65384787
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65364661
86Malaria_Homo sapiens_hsa051440.62450581
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61021402
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60682154
89Serotonergic synapse_Homo sapiens_hsa047260.60452283
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60000335
91Butanoate metabolism_Homo sapiens_hsa006500.59491829
92Biosynthesis of amino acids_Homo sapiens_hsa012300.58889063
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58772386
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.58278932
95Arginine and proline metabolism_Homo sapiens_hsa003300.58019963
96Steroid biosynthesis_Homo sapiens_hsa001000.57415091
97Proteasome_Homo sapiens_hsa030500.56403569
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54755206
99beta-Alanine metabolism_Homo sapiens_hsa004100.54735058
100Epstein-Barr virus infection_Homo sapiens_hsa051690.54442107
101Sulfur metabolism_Homo sapiens_hsa009200.54234257
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53859465
103Focal adhesion_Homo sapiens_hsa045100.53722065
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53446578
105Nicotine addiction_Homo sapiens_hsa050330.52601495
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51711011
107Ras signaling pathway_Homo sapiens_hsa040140.51669308
108Other glycan degradation_Homo sapiens_hsa005110.51159115
109Mineral absorption_Homo sapiens_hsa049780.50826953
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49519700
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48880159
112Parkinsons disease_Homo sapiens_hsa050120.47490127
113Graft-versus-host disease_Homo sapiens_hsa053320.47417118
114Regulation of autophagy_Homo sapiens_hsa041400.46321162
115Gap junction_Homo sapiens_hsa045400.45906844
116Metabolic pathways_Homo sapiens_hsa011000.45546615
117Proteoglycans in cancer_Homo sapiens_hsa052050.44740272
118Rheumatoid arthritis_Homo sapiens_hsa053230.44655567
119Caffeine metabolism_Homo sapiens_hsa002320.44464849
120Colorectal cancer_Homo sapiens_hsa052100.43466610
121Asthma_Homo sapiens_hsa053100.42154106
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.41853024
123Oxidative phosphorylation_Homo sapiens_hsa001900.41120019
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41081038
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41004181
126Hematopoietic cell lineage_Homo sapiens_hsa046400.40436826
127Huntingtons disease_Homo sapiens_hsa050160.39904718
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38068920
129Rap1 signaling pathway_Homo sapiens_hsa040150.37958310
130Bladder cancer_Homo sapiens_hsa052190.35667699
131ErbB signaling pathway_Homo sapiens_hsa040120.35566010
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35463963
133Thyroid cancer_Homo sapiens_hsa052160.35164687
134Sulfur relay system_Homo sapiens_hsa041220.33964354
135Viral carcinogenesis_Homo sapiens_hsa052030.33959336
136Vibrio cholerae infection_Homo sapiens_hsa051100.33482289
137Allograft rejection_Homo sapiens_hsa053300.33019264
138Dilated cardiomyopathy_Homo sapiens_hsa054140.32596657
139Cocaine addiction_Homo sapiens_hsa050300.32363093
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32072051
141Choline metabolism in cancer_Homo sapiens_hsa052310.31208999
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31071303
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.30795325

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