TULP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.06403288
2central nervous system myelination (GO:0022010)3.93449660
3axon ensheathment in central nervous system (GO:0032291)3.93449660
4dendrite morphogenesis (GO:0048813)3.80215747
5layer formation in cerebral cortex (GO:0021819)3.64279977
6nucleobase catabolic process (GO:0046113)3.58542150
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.54771669
8synaptic vesicle maturation (GO:0016188)3.54069366
9locomotory exploration behavior (GO:0035641)3.53525492
10dendritic spine morphogenesis (GO:0060997)3.52809892
11axonal fasciculation (GO:0007413)3.51058262
12neuron cell-cell adhesion (GO:0007158)3.50510307
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36185237
14neuron recognition (GO:0008038)3.35019628
15startle response (GO:0001964)3.20376099
16negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18631072
17cell migration in hindbrain (GO:0021535)3.16930760
18negative regulation of dendrite development (GO:2000171)3.14799616
19vocalization behavior (GO:0071625)3.12490029
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11489537
21protein K11-linked deubiquitination (GO:0035871)3.10413431
22atrial cardiac muscle cell action potential (GO:0086014)3.07387684
23behavioral response to nicotine (GO:0035095)3.03482858
24establishment of nucleus localization (GO:0040023)2.97709988
25regulation of hexokinase activity (GO:1903299)2.96901219
26regulation of glucokinase activity (GO:0033131)2.96901219
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.95991230
28cytoskeletal anchoring at plasma membrane (GO:0007016)2.95194222
29glycosphingolipid biosynthetic process (GO:0006688)2.95132397
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90321121
31neurotransmitter-gated ion channel clustering (GO:0072578)2.87364504
32ionotropic glutamate receptor signaling pathway (GO:0035235)2.86157003
33cerebellar granule cell differentiation (GO:0021707)2.85415129
34regulation of synaptic vesicle exocytosis (GO:2000300)2.85092687
35proline transport (GO:0015824)2.84872119
36response to pheromone (GO:0019236)2.84823313
37neural tube formation (GO:0001841)2.84555719
38cerebellar Purkinje cell differentiation (GO:0021702)2.82467089
39central nervous system projection neuron axonogenesis (GO:0021952)2.79918866
40keratinocyte development (GO:0003334)2.78759917
41sympathetic nervous system development (GO:0048485)2.78172378
42presynaptic membrane organization (GO:0097090)2.78009050
43inositol phosphate catabolic process (GO:0071545)2.75388055
44neuronal ion channel clustering (GO:0045161)2.75338315
45myelination (GO:0042552)2.74794933
46glial cell proliferation (GO:0014009)2.74674198
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73453869
48establishment of protein localization to Golgi (GO:0072600)2.72858682
49ensheathment of neurons (GO:0007272)2.72745225
50axon ensheathment (GO:0008366)2.72745225
51transmission of nerve impulse (GO:0019226)2.72372690
52apical protein localization (GO:0045176)2.72305507
53neuronal action potential (GO:0019228)2.71860003
54presynaptic membrane assembly (GO:0097105)2.70788334
55protein localization to cilium (GO:0061512)2.70704202
56negative regulation of neurotransmitter secretion (GO:0046929)2.69628748
57L-amino acid import (GO:0043092)2.68938793
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67669954
59regulation of axon extension involved in axon guidance (GO:0048841)2.67341301
60cerebral cortex radially oriented cell migration (GO:0021799)2.66663844
61regulation of axon guidance (GO:1902667)2.66595991
62membrane depolarization during action potential (GO:0086010)2.66214347
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64033242
64synaptic vesicle exocytosis (GO:0016079)2.63701803
65nerve growth factor signaling pathway (GO:0038180)2.62132229
66protein localization to synapse (GO:0035418)2.62033900
67asymmetric protein localization (GO:0008105)2.61914097
68cornea development in camera-type eye (GO:0061303)2.61678975
69cerebellar Purkinje cell layer development (GO:0021680)2.61124167
70glutamate secretion (GO:0014047)2.60709746
71neuronal action potential propagation (GO:0019227)2.60158386
72kidney morphogenesis (GO:0060993)2.59814951
73plasma membrane repair (GO:0001778)2.58110203
74protein polyglutamylation (GO:0018095)2.57480689
75neuromuscular process controlling balance (GO:0050885)2.57442919
76reflex (GO:0060004)2.56928070
77serotonin metabolic process (GO:0042428)2.56539881
78regulation of glutamate receptor signaling pathway (GO:1900449)2.56222662
79exploration behavior (GO:0035640)2.56160267
80positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.54826498
81adult walking behavior (GO:0007628)2.52131666
82establishment of mitochondrion localization (GO:0051654)2.51637023
83protein targeting to Golgi (GO:0000042)2.51633094
84synaptic transmission, glutamatergic (GO:0035249)2.51534373
85negative regulation of neurotransmitter transport (GO:0051589)2.49692110
86action potential (GO:0001508)2.49472362
87regulation of neuronal synaptic plasticity (GO:0048168)2.48926066
88regulation of synapse structural plasticity (GO:0051823)2.48515591
89glutamate receptor signaling pathway (GO:0007215)2.47874276
90dendritic spine organization (GO:0097061)2.47748217
91righting reflex (GO:0060013)2.46846236
92C4-dicarboxylate transport (GO:0015740)2.46786017
93synaptic vesicle endocytosis (GO:0048488)2.46579857
94negative regulation of axonogenesis (GO:0050771)2.45620830
95regulation of dendritic spine morphogenesis (GO:0061001)2.45280581
96synapse organization (GO:0050808)2.45111251
97cellular potassium ion homeostasis (GO:0030007)2.44855183
98organelle transport along microtubule (GO:0072384)2.43256357
99regulation of action potential (GO:0098900)2.43076975
100primary amino compound metabolic process (GO:1901160)2.42529202
101positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42408530
102axon extension (GO:0048675)2.41722845
103neuromuscular junction development (GO:0007528)2.41063789
104central nervous system neuron axonogenesis (GO:0021955)2.40842422
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40435365
106synaptic vesicle docking involved in exocytosis (GO:0016081)2.39571584
107vesicle transport along microtubule (GO:0047496)2.39537138
108retinal ganglion cell axon guidance (GO:0031290)2.39048807
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.38116683
110neuron-neuron synaptic transmission (GO:0007270)2.37470825
111postsynaptic membrane organization (GO:0001941)2.37351814
112innervation (GO:0060384)2.37236120
113retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37082902
114mating behavior (GO:0007617)2.36753077
115neuron projection morphogenesis (GO:0048812)2.36520330
116glycine transport (GO:0015816)2.36196164
117peripheral nervous system axon ensheathment (GO:0032292)2.35425903
118myelination in peripheral nervous system (GO:0022011)2.35425903
119ketone body metabolic process (GO:1902224)2.35363263
120cell differentiation in hindbrain (GO:0021533)2.34972169
121auditory behavior (GO:0031223)2.34939889
122regulation of synaptic vesicle transport (GO:1902803)2.34530467
123photoreceptor cell differentiation (GO:0046530)2.33910275
124eye photoreceptor cell differentiation (GO:0001754)2.33910275
125calcium ion-dependent exocytosis (GO:0017156)2.33614823
126behavioral response to ethanol (GO:0048149)2.33220875
127neuromuscular synaptic transmission (GO:0007274)2.33087308
128camera-type eye morphogenesis (GO:0048593)2.32819247
129synapse assembly (GO:0007416)2.32615725
130calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32390491
131negative regulation of axon extension (GO:0030517)2.32000009
132positive regulation of glycolytic process (GO:0045821)2.31451894
133detection of light stimulus involved in sensory perception (GO:0050962)2.31126006
134detection of light stimulus involved in visual perception (GO:0050908)2.31126006
135regulation of dendritic spine development (GO:0060998)2.30662940
136acrosome reaction (GO:0007340)2.30168510
137gamma-aminobutyric acid transport (GO:0015812)2.29945015
138intraciliary transport (GO:0042073)2.29521776
139limb bud formation (GO:0060174)2.29381878
140activation of protein kinase A activity (GO:0034199)2.29381658
141positive regulation of synapse assembly (GO:0051965)2.28845314
142negative regulation of axon guidance (GO:1902668)2.28457414
143protein localization to Golgi apparatus (GO:0034067)2.27304663
144cytoplasmic mRNA processing body assembly (GO:0033962)2.26950886
145regulation of neuron migration (GO:2001222)2.25705265
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.25694562
147regulation of long-term neuronal synaptic plasticity (GO:0048169)2.25251352
148myelin maintenance (GO:0043217)2.25188032
149somite development (GO:0061053)2.25064552
150insulin secretion (GO:0030073)2.24845569
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.24810775
152negative regulation of translation, ncRNA-mediated (GO:0040033)2.24810775
153regulation of translation, ncRNA-mediated (GO:0045974)2.24810775
154negative regulation of catenin import into nucleus (GO:0035414)2.24794579
155neurotransmitter secretion (GO:0007269)2.24766030
156neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.24676608
157long-term memory (GO:0007616)2.24544527
158prepulse inhibition (GO:0060134)2.24432100
159negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.24215325
160regulation of sarcomere organization (GO:0060297)2.23585219
161positive regulation of potassium ion transport (GO:0043268)2.23439522
162spinal cord development (GO:0021510)2.22592150
163regulation of postsynaptic membrane potential (GO:0060078)2.22271388
164positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.22013595
165regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.21591213
166appendage development (GO:0048736)2.20998504
167limb development (GO:0060173)2.20998504
168multicellular organismal signaling (GO:0035637)2.20761005
169retinal cone cell development (GO:0046549)2.20048678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.47836696
2GBX2_23144817_ChIP-Seq_PC3_Human2.88554012
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75964645
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48946893
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42138049
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38452270
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35827246
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35827246
9FUS_26573619_Chip-Seq_HEK293_Human2.28748363
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.16020437
11DROSHA_22980978_ChIP-Seq_HELA_Human2.11941181
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11838702
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06267123
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06244336
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05511623
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05193541
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03760006
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03074816
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00287564
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.00171333
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.96157933
22VDR_22108803_ChIP-Seq_LS180_Human1.95656292
23* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90062884
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86268705
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82794434
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81626205
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80444870
28EWS_26573619_Chip-Seq_HEK293_Human1.77495902
29AR_21572438_ChIP-Seq_LNCaP_Human1.74970601
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.73715729
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72948350
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70817784
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69477611
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62989180
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59394360
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58898526
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.58816497
38* REST_21632747_ChIP-Seq_MESCs_Mouse1.58579034
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57561808
40CBP_20019798_ChIP-Seq_JUKART_Human1.57561808
41* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55184645
42* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51036000
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49301582
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48812344
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48562014
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45859708
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44646592
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.44329558
49* BCAT_22108803_ChIP-Seq_LS180_Human1.43810056
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43750701
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.42910361
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42474896
53AHR_22903824_ChIP-Seq_MCF-7_Human1.41520198
54ZNF274_21170338_ChIP-Seq_K562_Hela1.40904616
55SMAD4_21799915_ChIP-Seq_A2780_Human1.38879690
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38500217
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38113397
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37781036
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37426313
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.37417495
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36396525
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.35548887
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35464780
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35464780
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35368676
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34904755
67STAT3_23295773_ChIP-Seq_U87_Human1.31370360
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31115695
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30964442
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.30497481
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30329168
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30236631
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.29684606
74TP53_16413492_ChIP-PET_HCT116_Human1.29275525
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.29137037
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27346501
77TCF4_22108803_ChIP-Seq_LS180_Human1.27268232
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.27215084
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27033157
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.26912583
81IGF1R_20145208_ChIP-Seq_DFB_Human1.26533989
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.25951639
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.24570523
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24085636
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22895492
86P53_22387025_ChIP-Seq_ESCs_Mouse1.22790338
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22680049
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22623271
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.21190097
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20631230
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.19299270
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.18645489
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18102272
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.17172882
95AR_19668381_ChIP-Seq_PC3_Human1.16900048
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13539160
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13346075
98* REST_18959480_ChIP-ChIP_MESCs_Mouse1.13302578
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.12590939
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12519513
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.11260492
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10653143
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10228485
104NANOG_19829295_ChIP-Seq_ESCs_Human1.09840650
105SOX2_19829295_ChIP-Seq_ESCs_Human1.09840650
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.08652518
107KDM2B_26808549_Chip-Seq_K562_Human1.08638206
108TCF4_23295773_ChIP-Seq_U87_Human1.08458185
109* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08382314
110KDM2B_26808549_Chip-Seq_REH_Human1.07716392
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07247925
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06695133
113CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06358018
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.06296186
115P300_19829295_ChIP-Seq_ESCs_Human1.05707434
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05481391
117TP53_18474530_ChIP-ChIP_U2OS_Human1.05227586
118* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05059734
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04774337
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04544275
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04032232
122* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02852405
123ISL1_27105846_Chip-Seq_CPCs_Mouse1.02608014
124ERG_21242973_ChIP-ChIP_JURKAT_Human1.02589106
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.02419773
126ER_23166858_ChIP-Seq_MCF-7_Human1.02360681
127AR_25329375_ChIP-Seq_VCAP_Human1.02008217
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01603509
129FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01005718
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00660371
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00611768
132CDX2_22108803_ChIP-Seq_LS180_Human0.99786985
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99531405
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99531405
135TAF15_26573619_Chip-Seq_HEK293_Human0.99225146
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.98909583
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97744800
138BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97482236
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.95314969
140* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95112466
141RUNX2_22187159_ChIP-Seq_PCA_Human0.93840967
142P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93794746
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.91805443
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91541188
145RNF2_27304074_Chip-Seq_NSC_Mouse0.91057754
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.90562120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.73739575
2MP0004270_analgesia3.24589994
3MP0002102_abnormal_ear_morphology2.77555632
4MP0003880_abnormal_central_pattern2.51970739
5MP0003635_abnormal_synaptic_transmissio2.45321301
6MP0001299_abnormal_eye_distance/2.30478389
7MP0000778_abnormal_nervous_system2.28085375
8MP0000569_abnormal_digit_pigmentation2.27968349
9MP0005423_abnormal_somatic_nervous2.27155161
10MP0009780_abnormal_chondrocyte_physiolo2.25121546
11MP0002822_catalepsy2.07180228
12MP0009046_muscle_twitch1.98498375
13MP0008877_abnormal_DNA_methylation1.96366003
14MP0001486_abnormal_startle_reflex1.95937450
15MP0002063_abnormal_learning/memory/cond1.95796288
16MP0002837_dystrophic_cardiac_calcinosis1.91759292
17MP0002734_abnormal_mechanical_nocicepti1.89154988
18MP0000920_abnormal_myelination1.85192816
19MP0000372_irregular_coat_pigmentation1.84853870
20MP0002064_seizures1.84254386
21MP0008438_abnormal_cutaneous_collagen1.84193353
22MP0002638_abnormal_pupillary_reflex1.82143677
23MP0005623_abnormal_meninges_morphology1.81875733
24MP0009745_abnormal_behavioral_response1.81191191
25MP0005253_abnormal_eye_physiology1.78960372
26MP0003195_calcinosis1.72070834
27MP0006276_abnormal_autonomic_nervous1.71934839
28MP0002272_abnormal_nervous_system1.67704288
29MP0003283_abnormal_digestive_organ1.67598712
30MP0004885_abnormal_endolymph1.67070776
31MP0002184_abnormal_innervation1.62695603
32MP0002736_abnormal_nociception_after1.61986237
33MP0002572_abnormal_emotion/affect_behav1.57424900
34MP0000955_abnormal_spinal_cord1.50525729
35MP0005174_abnormal_tail_pigmentation1.49405678
36MP0004742_abnormal_vestibular_system1.48806637
37MP0006072_abnormal_retinal_apoptosis1.46875595
38MP0008569_lethality_at_weaning1.46773248
39MP0002938_white_spotting1.45832578
40MP0000427_abnormal_hair_cycle1.42454966
41MP0003787_abnormal_imprinting1.42405515
42MP0004145_abnormal_muscle_electrophysio1.42323334
43MP0004858_abnormal_nervous_system1.38568231
44MP0002882_abnormal_neuron_morphology1.38404339
45MP0003646_muscle_fatigue1.37556268
46MP0003890_abnormal_embryonic-extraembry1.37092118
47MP0000751_myopathy1.35370794
48MP0004811_abnormal_neuron_physiology1.35316826
49MP0002067_abnormal_sensory_capabilities1.34219826
50MP0003634_abnormal_glial_cell1.34098824
51MP0000537_abnormal_urethra_morphology1.33223832
52MP0003121_genomic_imprinting1.32432910
53MP0005503_abnormal_tendon_morphology1.32198559
54MP0001440_abnormal_grooming_behavior1.30864203
55MP0005408_hypopigmentation1.30714813
56MP0003329_amyloid_beta_deposits1.30495708
57MP0005171_absent_coat_pigmentation1.28810962
58MP0002751_abnormal_autonomic_nervous1.28783785
59MP0002557_abnormal_social/conspecific_i1.26417193
60MP0002909_abnormal_adrenal_gland1.25335696
61MP0000015_abnormal_ear_pigmentation1.24824143
62MP0005075_abnormal_melanosome_morpholog1.24043893
63MP0003385_abnormal_body_wall1.23715965
64MP0003690_abnormal_glial_cell1.22603712
65MP0001986_abnormal_taste_sensitivity1.21729666
66MP0000534_abnormal_ureter_morphology1.20640996
67MP0002234_abnormal_pharynx_morphology1.20018666
68MP0001529_abnormal_vocalization1.18802897
69MP0004924_abnormal_behavior1.18745172
70MP0005386_behavior/neurological_phenoty1.18745172
71MP0004133_heterotaxia1.18341541
72MP0000013_abnormal_adipose_tissue1.18218657
73MP0000647_abnormal_sebaceous_gland1.17525859
74MP0009250_abnormal_appendicular_skeleto1.16533258
75MP0000733_abnormal_muscle_development1.15593143
76MP0001188_hyperpigmentation1.15189851
77MP0001968_abnormal_touch/_nociception1.14019702
78MP0005187_abnormal_penis_morphology1.13643813
79MP0002152_abnormal_brain_morphology1.12480475
80MP0004134_abnormal_chest_morphology1.11769991
81MP0005645_abnormal_hypothalamus_physiol1.11527610
82MP0004142_abnormal_muscle_tone1.11014986
83MP0002733_abnormal_thermal_nociception1.10629617
84MP0003122_maternal_imprinting1.10561119
85MP0001177_atelectasis1.10440877
86MP0003045_fibrosis1.10359773
87MP0002066_abnormal_motor_capabilities/c1.08543919
88MP0001970_abnormal_pain_threshold1.08319015
89MP0003755_abnormal_palate_morphology1.06259273
90MP0003950_abnormal_plasma_membrane1.05824556
91MP0000631_abnormal_neuroendocrine_gland1.04593595
92MP0005275_abnormal_skin_tensile1.03801329
93MP0004215_abnormal_myocardial_fiber1.03771376
94MP0000462_abnormal_digestive_system1.02963170
95MP0002896_abnormal_bone_mineralization1.02711981
96MP0002095_abnormal_skin_pigmentation1.02211034
97MP0003937_abnormal_limbs/digits/tail_de1.01246553
98MP0005646_abnormal_pituitary_gland1.00849986
99MP0005367_renal/urinary_system_phenotyp1.00655398
100MP0000516_abnormal_urinary_system1.00655398
101MP0010030_abnormal_orbit_morphology1.00126567
102MP0000428_abnormal_craniofacial_morphol0.99855939
103MP0002108_abnormal_muscle_morphology0.99796325
104MP0003136_yellow_coat_color0.99366578
105MP0000383_abnormal_hair_follicle0.99240917
106MP0001346_abnormal_lacrimal_gland0.98530688
107MP0004043_abnormal_pH_regulation0.97765286
108MP0005248_abnormal_Harderian_gland0.96978789
109MP0000003_abnormal_adipose_tissue0.96454318
110MP0003632_abnormal_nervous_system0.94969272
111MP0003861_abnormal_nervous_system0.94687222
112MP0002090_abnormal_vision0.94612854
113MP0004233_abnormal_muscle_weight0.93506653
114MP0004085_abnormal_heartbeat0.93427981
115MP0003011_delayed_dark_adaptation0.92285330
116MP0001984_abnormal_olfaction0.91959079
117MP0003091_abnormal_cell_migration0.91872979
118MP0002160_abnormal_reproductive_system0.91807727
119MP0000579_abnormal_nail_morphology0.91537826
120MP0001501_abnormal_sleep_pattern0.90772510
121MP0002876_abnormal_thyroid_physiology0.90501117
122MP0001485_abnormal_pinna_reflex0.89758234
123MP0010234_abnormal_vibrissa_follicle0.89692434
124MP0002233_abnormal_nose_morphology0.89395899
125MP0002735_abnormal_chemical_nociception0.88187477
126MP0005257_abnormal_intraocular_pressure0.88078294
127MP0002752_abnormal_somatic_nervous0.87584664
128MP0003119_abnormal_digestive_system0.87419127
129MP0004147_increased_porphyrin_level0.87202742
130MP0001905_abnormal_dopamine_level0.87074547
131MP0001958_emphysema0.86351249
132MP0002229_neurodegeneration0.85765308
133MP0003633_abnormal_nervous_system0.85692282
134MP0005551_abnormal_eye_electrophysiolog0.85288444
135MP0005195_abnormal_posterior_eye0.84494570
136MP0003631_nervous_system_phenotype0.84295818
137MP0003942_abnormal_urinary_system0.84294398
138MP0001502_abnormal_circadian_rhythm0.83880990
139MP0000747_muscle_weakness0.83578156
140MP0001849_ear_inflammation0.82836860
141MP0001324_abnormal_eye_pigmentation0.82275464
142MP0010678_abnormal_skin_adnexa0.80549792
143MP0003137_abnormal_impulse_conducting0.80463662
144MP0010386_abnormal_urinary_bladder0.80224283
145MP0005391_vision/eye_phenotype0.78411364
146MP0002116_abnormal_craniofacial_bone0.77591413

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.11226430
2Degeneration of the lateral corticospinal tracts (HP:0002314)3.01515803
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.01515803
4Action tremor (HP:0002345)3.01213828
5Abnormality of the corticospinal tract (HP:0002492)3.00597954
6Myokymia (HP:0002411)2.93034863
7Chronic hepatic failure (HP:0100626)2.86989322
8Shallow orbits (HP:0000586)2.86116825
9Insidious onset (HP:0003587)2.85342187
10Termporal pattern (HP:0011008)2.85342187
11Hypothermia (HP:0002045)2.82813954
12Pancreatic cysts (HP:0001737)2.80573839
13Focal motor seizures (HP:0011153)2.80024101
14Nephronophthisis (HP:0000090)2.76626842
15Focal seizures (HP:0007359)2.73470525
16Supranuclear gaze palsy (HP:0000605)2.72583336
17Epileptiform EEG discharges (HP:0011182)2.61534253
18Ankle clonus (HP:0011448)2.59886624
19Intestinal atresia (HP:0011100)2.59552248
20Macroorchidism (HP:0000053)2.58679866
21Bell-shaped thorax (HP:0001591)2.58594016
22EEG with generalized epileptiform discharges (HP:0011198)2.54212582
23Neoplasm of the adrenal cortex (HP:0100641)2.50647510
24Neurofibrillary tangles (HP:0002185)2.50448643
25Dialeptic seizures (HP:0011146)2.48603163
26Hypsarrhythmia (HP:0002521)2.47869344
27Congenital stationary night blindness (HP:0007642)2.47419115
28Progressive cerebellar ataxia (HP:0002073)2.46390938
29Pancreatic fibrosis (HP:0100732)2.46284668
30Megalencephaly (HP:0001355)2.45362595
31Inability to walk (HP:0002540)2.43726664
32Aqueductal stenosis (HP:0002410)2.42485035
33Abnormality of the renal medulla (HP:0100957)2.41147066
34Aplasia involving bones of the extremities (HP:0009825)2.39191014
35Aplasia involving bones of the upper limbs (HP:0009823)2.39191014
36Aplasia of the phalanges of the hand (HP:0009802)2.39191014
37Abnormality of the labia minora (HP:0012880)2.38313083
38Premature rupture of membranes (HP:0001788)2.37654818
39Medial flaring of the eyebrow (HP:0010747)2.35064149
40True hermaphroditism (HP:0010459)2.32822368
41Broad metatarsal (HP:0001783)2.27620228
42Abnormality of the astrocytes (HP:0100707)2.26069898
43Astrocytoma (HP:0009592)2.26069898
44Abnormality of midbrain morphology (HP:0002418)2.25047460
45Molar tooth sign on MRI (HP:0002419)2.25047460
46Buphthalmos (HP:0000557)2.24137238
47Abnormality of the renal cortex (HP:0011035)2.23472793
48Fair hair (HP:0002286)2.21814084
49Oligodactyly (hands) (HP:0001180)2.20591462
50Spastic gait (HP:0002064)2.18158660
51Generalized hypopigmentation of hair (HP:0011358)2.17714232
52Gait imbalance (HP:0002141)2.16029299
53Limb dystonia (HP:0002451)2.15519366
54Tubulointerstitial nephritis (HP:0001970)2.15093943
55Coronal craniosynostosis (HP:0004440)2.13325523
56Cerebral inclusion bodies (HP:0100314)2.12564651
57Excessive salivation (HP:0003781)2.11230414
58Drooling (HP:0002307)2.11230414
59Genital tract atresia (HP:0001827)2.07412766
60Lower limb amyotrophy (HP:0007210)2.06548303
61Difficulty running (HP:0009046)2.06114827
62Turricephaly (HP:0000262)2.05801571
63Progressive inability to walk (HP:0002505)2.05698621
64Lissencephaly (HP:0001339)2.05686657
65Hamartoma of the eye (HP:0010568)2.03913420
66Amblyopia (HP:0000646)2.03798912
67Onion bulb formation (HP:0003383)2.03745056
68Thyroiditis (HP:0100646)2.02939910
69Renal cortical cysts (HP:0000803)2.02762962
70Alacrima (HP:0000522)2.02306468
71Dysmetria (HP:0001310)2.01632200
72Urinary urgency (HP:0000012)1.99688783
73Genetic anticipation (HP:0003743)1.99105493
74Intention tremor (HP:0002080)1.98774316
75Overgrowth (HP:0001548)1.98392286
76Generalized tonic-clonic seizures (HP:0002069)1.96854475
77Lower limb muscle weakness (HP:0007340)1.96275765
78Aplasia/Hypoplasia of the fovea (HP:0008060)1.96113370
79Hypoplasia of the fovea (HP:0007750)1.96113370
80Congenital sensorineural hearing impairment (HP:0008527)1.96015717
81Type II lissencephaly (HP:0007260)1.95950205
82Vaginal atresia (HP:0000148)1.95600817
83Broad-based gait (HP:0002136)1.95427319
84Protruding tongue (HP:0010808)1.95277865
85Absence seizures (HP:0002121)1.94438819
86Methylmalonic acidemia (HP:0002912)1.94271999
87Infantile muscular hypotonia (HP:0008947)1.94170128
88Urinary bladder sphincter dysfunction (HP:0002839)1.93297467
89Scapular winging (HP:0003691)1.93195030
90Congenital primary aphakia (HP:0007707)1.92171243
91Hyporeflexia of lower limbs (HP:0002600)1.90680794
92Truncal ataxia (HP:0002078)1.89700104
93Optic nerve hypoplasia (HP:0000609)1.89697259
94Widely spaced teeth (HP:0000687)1.85435566
95Labial hypoplasia (HP:0000066)1.85092685
96Glioma (HP:0009733)1.85033522
97Epileptic encephalopathy (HP:0200134)1.84535642
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.83825234
99Dysdiadochokinesis (HP:0002075)1.83659701
100Pachygyria (HP:0001302)1.82885339
101Bladder diverticulum (HP:0000015)1.82607617
102Hemiparesis (HP:0001269)1.82521213
103Abnormality of the fovea (HP:0000493)1.82508608
104Nephrogenic diabetes insipidus (HP:0009806)1.82397890
105Hypoplastic labia majora (HP:0000059)1.81379679
106Volvulus (HP:0002580)1.81103410
107Overriding aorta (HP:0002623)1.80621280
108Papillary thyroid carcinoma (HP:0002895)1.79595052
109Abnormality of macular pigmentation (HP:0008002)1.77787283
110Gaze-evoked nystagmus (HP:0000640)1.77705439
111Neuroendocrine neoplasm (HP:0100634)1.75983451
112Congenital glaucoma (HP:0001087)1.75577693
113Agitation (HP:0000713)1.74984670
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74610399
115Bronchomalacia (HP:0002780)1.73935494
116Atonic seizures (HP:0010819)1.73658826
117Anteriorly placed anus (HP:0001545)1.73588866
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73551090
119Blue irides (HP:0000635)1.72737695
120Cystic liver disease (HP:0006706)1.72047405
121Scanning speech (HP:0002168)1.71410720
122Abnormality of vitamin B metabolism (HP:0004340)1.71303132
123Akinesia (HP:0002304)1.70557799
124Ketoacidosis (HP:0001993)1.70346897
125Poor coordination (HP:0002370)1.70180704
126Decreased motor nerve conduction velocity (HP:0003431)1.68892725
127Thyroid carcinoma (HP:0002890)1.68680768
128Atrophic scars (HP:0001075)1.68373501
129Impaired vibration sensation in the lower limbs (HP:0002166)1.67970349
130Hypoplastic ischia (HP:0003175)1.67088410
131Visual hallucinations (HP:0002367)1.67047759
132Abnormality of the labia majora (HP:0012881)1.66206664
133Decreased lacrimation (HP:0000633)1.66199427
134Pendular nystagmus (HP:0012043)1.65795995
135Febrile seizures (HP:0002373)1.65661391
136Calf muscle hypertrophy (HP:0008981)1.65575810
137Gastrointestinal atresia (HP:0002589)1.65155204
138Specific learning disability (HP:0001328)1.64919230
139Abnormality of the metopic suture (HP:0005556)1.64782022
140Postaxial hand polydactyly (HP:0001162)1.64425129
141Broad ribs (HP:0000885)1.61528184
142Cerebellar dysplasia (HP:0007033)1.61514212
143Pheochromocytoma (HP:0002666)1.61478528
144Neoplasm of the adrenal gland (HP:0100631)1.61064245
145Renal hypoplasia (HP:0000089)1.61056470
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60341544
147Hammertoe (HP:0001765)1.60087161
148Peripheral hypomyelination (HP:0007182)1.60058178
149Insomnia (HP:0100785)1.60006229
150Fetal akinesia sequence (HP:0001989)1.59900489
151Aplasia/Hypoplasia of the brainstem (HP:0007362)1.59574342
152Hypoplasia of the brainstem (HP:0002365)1.59574342
153Ependymoma (HP:0002888)1.59171011
154Flat cornea (HP:0007720)1.59026537
155Increased corneal curvature (HP:0100692)1.56988405
156Vascular tortuosity (HP:0004948)1.56897522
157Neoplasm of the heart (HP:0100544)1.56889762
158Open mouth (HP:0000194)1.55938971
159Absent speech (HP:0001344)1.55193051
160Increased variability in muscle fiber diameter (HP:0003557)1.54010583
161Hepatoblastoma (HP:0002884)1.53590501
162Bowel diverticulosis (HP:0005222)1.53489001
163Abnormality of the ischium (HP:0003174)1.53055753
164Cerebral aneurysm (HP:0004944)1.52523926
165Arterial tortuosity (HP:0005116)1.52088426
166Depression (HP:0000716)1.52001798
167Bowel incontinence (HP:0002607)1.50977531
168Exotropia (HP:0000577)1.50798232
169Hypoventilation (HP:0002791)1.50172989
170Abnormality of salivation (HP:0100755)1.49514934
171Arnold-Chiari malformation (HP:0002308)1.48051961
172Protrusio acetabuli (HP:0003179)1.47798600
173Abnormal auditory evoked potentials (HP:0006958)1.46080039
174Prolonged QT interval (HP:0001657)1.45978364
175Cutaneous finger syndactyly (HP:0010554)1.45976088
176Intellectual disability, moderate (HP:0002342)1.45801758
177Narrow palate (HP:0000189)1.44471234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.54221905
2TRIM282.97585617
3MAP4K22.87101496
4NTRK32.74374657
5ICK2.42714712
6PINK12.42040693
7STK392.41805813
8PAK62.22136517
9PRKD32.19368015
10FGFR22.08079707
11DDR21.99869018
12WNK11.86836094
13NTRK11.85765419
14CAMK1G1.84846774
15AKT31.83600789
16NTRK21.77286023
17MAP3K41.74682086
18LATS11.70006686
19BMPR1B1.69521995
20MAP3K91.68701111
21PNCK1.59167002
22GRK11.56735237
23UHMK11.54040812
24PDGFRA1.51466188
25PAK31.49660586
26EPHA41.47200575
27OXSR11.47067211
28ACVR1B1.47020675
29TYRO31.45890947
30MINK11.45573314
31BCR1.39658597
32PHKG11.30919482
33PHKG21.30919482
34CSNK1A1L1.29820979
35EPHB11.29264565
36ADRBK21.26559998
37LIMK11.26044673
38DMPK1.24438003
39PKN11.21548668
40CDK51.18472555
41SGK4941.17481651
42SGK2231.17481651
43RIPK11.16924946
44MAP3K21.15608914
45OBSCN1.15466715
46CSNK1G21.14474505
47WNK41.12872362
48CASK1.11904261
49MARK21.10169132
50PRKCH1.09923845
51MAPK131.09323803
52NUAK11.08227591
53CAMKK11.08064382
54KSR11.05958957
55CAMK1D1.05210206
56PRKCG1.03018908
57EPHA31.01791761
58ERBB31.00531006
59TTN0.99037246
60STK38L0.98704201
61EPHB20.96019689
62DAPK20.94102109
63CAMK2B0.93064124
64STK380.90701230
65LATS20.90251820
66RET0.89252275
67NLK0.89051748
68PDGFRB0.88962928
69CSNK1G30.87827671
70FER0.86021198
71PTK20.85351429
72ROCK20.84779512
73CDC42BPA0.83560415
74TRIB30.82821487
75STK110.82700670
76MKNK20.82477814
77CAMK2D0.79334569
78CSNK1G10.78669891
79ZAK0.78075929
80CCNB10.75282939
81MET0.74326606
82CAMK2A0.73812817
83HIPK20.73521844
84MAPKAPK50.73187583
85CDK140.72566977
86TNIK0.72070241
87ROCK10.71026411
88CDK150.70980205
89NEK60.70935115
90CDK180.70243264
91CAMKK20.70066110
92SIK20.70057873
93MAP2K70.69394943
94PRPF4B0.67955265
95ALK0.67343317
96KSR20.66430295
97SGK10.66399691
98FGFR10.65980237
99PRKD10.64506069
100SGK30.63510143
101PRKCE0.61634885
102PAK20.61566412
103DYRK20.61512652
104MAP2K40.61266982
105PRKAA10.60766971
106CSNK1D0.59476589
107WNK30.58600300
108TAOK10.58015442
109CDK11A0.57219494
110MTOR0.57210496
111PTK60.57029764
112BRD40.56731298
113PLK20.56566725
114MAPK100.55759930
115ERBB20.55316444
116INSRR0.55121382
117SGK20.54721338
118LMTK20.54655392
119FRK0.54532239
120FYN0.53308983
121PRKCZ0.52351193
122CSNK1A10.51584573
123MUSK0.45354953
124CAMK10.45040721
125DYRK1A0.44457660
126PRKAA20.43558092
127EIF2AK30.43041379
128STK30.43027195
129SIK30.42957887
130ADRBK10.42490675
131PLK30.41331766
132PRKCI0.41085845
133PRKACA0.39830670
134PTK2B0.39740222
135CAMK40.37030454
136PIK3CA0.36997984
137PRKG10.36993830
138PRKACB0.35822760
139CDK30.35817593
140PDK20.34875774
141FGFR30.30979033
142PLK40.30867362
143RPS6KA30.30167217

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.52291860
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35092998
3Butanoate metabolism_Homo sapiens_hsa006502.08974547
4Nicotine addiction_Homo sapiens_hsa050332.05065893
5Axon guidance_Homo sapiens_hsa043601.90980475
6Glutamatergic synapse_Homo sapiens_hsa047241.88191357
7Circadian entrainment_Homo sapiens_hsa047131.87448922
8GABAergic synapse_Homo sapiens_hsa047271.84579799
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80677894
10Circadian rhythm_Homo sapiens_hsa047101.70503599
11Protein export_Homo sapiens_hsa030601.69041312
12Synaptic vesicle cycle_Homo sapiens_hsa047211.66636099
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66036078
14Morphine addiction_Homo sapiens_hsa050321.64072234
15Insulin secretion_Homo sapiens_hsa049111.63729290
16Dopaminergic synapse_Homo sapiens_hsa047281.59158767
17Cocaine addiction_Homo sapiens_hsa050301.58514326
18Long-term potentiation_Homo sapiens_hsa047201.57958628
19Amphetamine addiction_Homo sapiens_hsa050311.57615714
20Cholinergic synapse_Homo sapiens_hsa047251.56950088
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52852863
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51771371
23Olfactory transduction_Homo sapiens_hsa047401.48672424
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47832088
25Type II diabetes mellitus_Homo sapiens_hsa049301.47384599
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46064182
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45412479
28Salivary secretion_Homo sapiens_hsa049701.44198103
29Dorso-ventral axis formation_Homo sapiens_hsa043201.43668393
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42482433
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39611705
32Gastric acid secretion_Homo sapiens_hsa049711.37843455
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37612286
34Long-term depression_Homo sapiens_hsa047301.35102158
35Dilated cardiomyopathy_Homo sapiens_hsa054141.34596966
36GnRH signaling pathway_Homo sapiens_hsa049121.33283424
37ErbB signaling pathway_Homo sapiens_hsa040121.33246241
38Propanoate metabolism_Homo sapiens_hsa006401.33091775
39Gap junction_Homo sapiens_hsa045401.32760294
40Serotonergic synapse_Homo sapiens_hsa047261.32511691
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29808468
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27878580
43Taste transduction_Homo sapiens_hsa047421.27584043
44Glioma_Homo sapiens_hsa052141.25853444
45Renal cell carcinoma_Homo sapiens_hsa052111.25846736
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25486671
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25036127
48Oxytocin signaling pathway_Homo sapiens_hsa049211.24615885
49Renin secretion_Homo sapiens_hsa049241.23075139
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22618557
51Estrogen signaling pathway_Homo sapiens_hsa049151.20134753
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19777846
53Collecting duct acid secretion_Homo sapiens_hsa049661.18479103
54Linoleic acid metabolism_Homo sapiens_hsa005911.17876409
55Basal transcription factors_Homo sapiens_hsa030221.09329773
56cAMP signaling pathway_Homo sapiens_hsa040241.08680488
57Endometrial cancer_Homo sapiens_hsa052131.07437810
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.07326304
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06939657
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06661084
61Regulation of autophagy_Homo sapiens_hsa041401.06395254
62Tight junction_Homo sapiens_hsa045301.05674672
63ABC transporters_Homo sapiens_hsa020101.04887237
64Melanogenesis_Homo sapiens_hsa049161.01729188
65Focal adhesion_Homo sapiens_hsa045101.01460378
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.00560210
67Steroid biosynthesis_Homo sapiens_hsa001000.99727333
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99416952
69Hippo signaling pathway_Homo sapiens_hsa043900.98890514
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.98382021
71Hedgehog signaling pathway_Homo sapiens_hsa043400.97867446
72ECM-receptor interaction_Homo sapiens_hsa045120.96994192
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95636471
74Calcium signaling pathway_Homo sapiens_hsa040200.94838302
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94292540
76Basal cell carcinoma_Homo sapiens_hsa052170.92340462
77Wnt signaling pathway_Homo sapiens_hsa043100.91338343
78Choline metabolism in cancer_Homo sapiens_hsa052310.90864769
79Tryptophan metabolism_Homo sapiens_hsa003800.90588630
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89992044
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89394640
82Proteoglycans in cancer_Homo sapiens_hsa052050.88488336
83MAPK signaling pathway_Homo sapiens_hsa040100.87916157
84Ras signaling pathway_Homo sapiens_hsa040140.87437096
85Selenocompound metabolism_Homo sapiens_hsa004500.87305832
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86128230
87Endocytosis_Homo sapiens_hsa041440.81521601
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79504208
89Rap1 signaling pathway_Homo sapiens_hsa040150.78853017
90Phototransduction_Homo sapiens_hsa047440.78570278
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78188517
92Ovarian steroidogenesis_Homo sapiens_hsa049130.78019490
93Peroxisome_Homo sapiens_hsa041460.77944020
94Ether lipid metabolism_Homo sapiens_hsa005650.77114988
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77022943
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.76807120
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.76440797
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.76235271
99Oocyte meiosis_Homo sapiens_hsa041140.76228969
100Pancreatic secretion_Homo sapiens_hsa049720.75980480
101Thyroid hormone synthesis_Homo sapiens_hsa049180.75878887
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75721575
103mTOR signaling pathway_Homo sapiens_hsa041500.75334092
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74669542
105Sulfur metabolism_Homo sapiens_hsa009200.72603648
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71634414
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71541774
108Nitrogen metabolism_Homo sapiens_hsa009100.71323129
109Fatty acid biosynthesis_Homo sapiens_hsa000610.71175402
110Fat digestion and absorption_Homo sapiens_hsa049750.70871666
111Fanconi anemia pathway_Homo sapiens_hsa034600.70510619
112Adherens junction_Homo sapiens_hsa045200.70174263
113Colorectal cancer_Homo sapiens_hsa052100.70031881
114Oxidative phosphorylation_Homo sapiens_hsa001900.69163340
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68475172
116Chronic myeloid leukemia_Homo sapiens_hsa052200.65597676
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65401320
118Non-homologous end-joining_Homo sapiens_hsa034500.65359285
119Prostate cancer_Homo sapiens_hsa052150.65123859
120Cardiac muscle contraction_Homo sapiens_hsa042600.64042516
121MicroRNAs in cancer_Homo sapiens_hsa052060.64038927
122Inositol phosphate metabolism_Homo sapiens_hsa005620.63736106
123VEGF signaling pathway_Homo sapiens_hsa043700.62046457
124Caffeine metabolism_Homo sapiens_hsa002320.61665807
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60813855
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60776627
127Melanoma_Homo sapiens_hsa052180.60715518
128Amoebiasis_Homo sapiens_hsa051460.58674244
129Alcoholism_Homo sapiens_hsa050340.58169113
130beta-Alanine metabolism_Homo sapiens_hsa004100.58105119
131Retinol metabolism_Homo sapiens_hsa008300.57169386
132Histidine metabolism_Homo sapiens_hsa003400.56812060
133Vibrio cholerae infection_Homo sapiens_hsa051100.56719792
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56476195
135Glucagon signaling pathway_Homo sapiens_hsa049220.56040043
136Non-small cell lung cancer_Homo sapiens_hsa052230.55907469
137Mineral absorption_Homo sapiens_hsa049780.53755847
138Insulin signaling pathway_Homo sapiens_hsa049100.53269204
139Protein digestion and absorption_Homo sapiens_hsa049740.52906889
140Prolactin signaling pathway_Homo sapiens_hsa049170.52436512
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51959131
142Sphingolipid metabolism_Homo sapiens_hsa006000.50239236
143TGF-beta signaling pathway_Homo sapiens_hsa043500.49802548
144RNA degradation_Homo sapiens_hsa030180.48894879
145Chemical carcinogenesis_Homo sapiens_hsa052040.48402564
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47458354
147Vitamin digestion and absorption_Homo sapiens_hsa049770.47084795

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