TUNAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene produces a spliced long non-coding RNA that may play a role in maintaining pluripotency and the neural differentiation of embryonic stem cells. Expression of this lncRNA in the caudate nucleus of brains from Huntington's Disease patients has been found to decrease as the disease progresses. It has also been suggested that this transcript may play a role in the progression of breast cancer. Alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.92997120
2polyketide metabolic process (GO:0030638)6.92997120
3doxorubicin metabolic process (GO:0044598)6.92997120
4synaptic vesicle maturation (GO:0016188)5.90389654
5vocalization behavior (GO:0071625)5.39374460
6proline transport (GO:0015824)5.18798145
7regulation of posttranscriptional gene silencing (GO:0060147)5.18272813
8regulation of gene silencing by miRNA (GO:0060964)5.18272813
9regulation of gene silencing by RNA (GO:0060966)5.18272813
10neuron cell-cell adhesion (GO:0007158)4.99395821
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.92334614
12locomotory exploration behavior (GO:0035641)4.85687740
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73416515
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.72421819
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.49927507
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41956155
17aminoglycoside antibiotic metabolic process (GO:0030647)4.32850956
18regulation of glutamate receptor signaling pathway (GO:1900449)4.29918194
19synaptic vesicle exocytosis (GO:0016079)4.16913896
20glutamate secretion (GO:0014047)4.15817373
21protein localization to synapse (GO:0035418)4.10482112
22glutamate receptor signaling pathway (GO:0007215)4.04888485
23synaptic transmission, glutamatergic (GO:0035249)4.03961963
24exploration behavior (GO:0035640)4.03451830
25regulation of synaptic vesicle exocytosis (GO:2000300)4.02337538
26response to pheromone (GO:0019236)3.96563265
27cerebellar granule cell differentiation (GO:0021707)3.90086954
28neurotransmitter secretion (GO:0007269)3.85522162
29neuron-neuron synaptic transmission (GO:0007270)3.72420432
30dendritic spine morphogenesis (GO:0060997)3.71968456
31pyrimidine nucleobase catabolic process (GO:0006208)3.71496663
32regulation of synaptic vesicle transport (GO:1902803)3.68496672
33gamma-aminobutyric acid transport (GO:0015812)3.64561858
34positive regulation of synapse maturation (GO:0090129)3.53111287
35neurotransmitter transport (GO:0006836)3.52873624
36maintenance of protein location in nucleus (GO:0051457)3.51815062
37auditory behavior (GO:0031223)3.51814290
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51418424
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50003936
40somite rostral/caudal axis specification (GO:0032525)3.49768147
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49496390
42pre-miRNA processing (GO:0031054)3.47079585
43cerebellar Purkinje cell differentiation (GO:0021702)3.42359964
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42137874
45postsynaptic membrane organization (GO:0001941)3.42052135
46calcium-mediated signaling using intracellular calcium source (GO:0035584)3.39957475
47layer formation in cerebral cortex (GO:0021819)3.35680692
48long-term memory (GO:0007616)3.31311412
49transmission of nerve impulse (GO:0019226)3.30176924
50neuron recognition (GO:0008038)3.29130542
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.28241479
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27815719
53single strand break repair (GO:0000012)3.26476035
54behavioral fear response (GO:0001662)3.26111374
55behavioral defense response (GO:0002209)3.26111374
56response to auditory stimulus (GO:0010996)3.25428487
57ventricular system development (GO:0021591)3.25121847
58nucleobase catabolic process (GO:0046113)3.23329202
59neuromuscular process controlling posture (GO:0050884)3.16647578
60startle response (GO:0001964)3.15513706
61regulation of neuronal synaptic plasticity (GO:0048168)3.13875284
62regulation of synapse structural plasticity (GO:0051823)3.13063326
63regulation of neurotransmitter levels (GO:0001505)3.11185615
64righting reflex (GO:0060013)3.10484452
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09938665
66phenol-containing compound catabolic process (GO:0019336)3.09860515
67neuronal action potential propagation (GO:0019227)3.09579154
68histone H4-K12 acetylation (GO:0043983)3.07018513
69histone H4-K5 acetylation (GO:0043981)3.06087704
70histone H4-K8 acetylation (GO:0043982)3.06087704
71central nervous system projection neuron axonogenesis (GO:0021952)3.04375185
72presynaptic membrane assembly (GO:0097105)3.03502065
73cell migration in hindbrain (GO:0021535)3.02801154
74neurotransmitter uptake (GO:0001504)3.02442241
75regulation of response to osmotic stress (GO:0047484)3.02212084
76neurotransmitter-gated ion channel clustering (GO:0072578)3.01977624
77response to dietary excess (GO:0002021)3.01924136
78synaptic vesicle docking involved in exocytosis (GO:0016081)3.01472564
79regulation of mammary gland epithelial cell proliferation (GO:0033599)3.00489393
80positive regulation of synapse assembly (GO:0051965)3.00448756
81fear response (GO:0042596)2.99103703
82regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98872185
83cell differentiation in hindbrain (GO:0021533)2.98670325
84positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98505693
85behavioral response to nicotine (GO:0035095)2.98052846
86regulation of synapse maturation (GO:0090128)2.97763717
87regulation of postsynaptic membrane potential (GO:0060078)2.96611644
88paraxial mesoderm development (GO:0048339)2.94352570
89regulation of respiratory system process (GO:0044065)2.93609735
90axonal fasciculation (GO:0007413)2.92844763
91kidney morphogenesis (GO:0060993)2.92715134
92synaptic vesicle endocytosis (GO:0048488)2.91736080
93regulation of MHC class I biosynthetic process (GO:0045343)2.90074106
94presynaptic membrane organization (GO:0097090)2.89120518
95cellular potassium ion homeostasis (GO:0030007)2.88990091
96synapse assembly (GO:0007416)2.87529180
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85876678
98regulation of cilium movement (GO:0003352)2.84362116
99membrane hyperpolarization (GO:0060081)2.83667259
100water-soluble vitamin biosynthetic process (GO:0042364)2.83418007
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.83130171
102response to histamine (GO:0034776)2.82837685
103negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81987330
104negative regulation of translation, ncRNA-mediated (GO:0040033)2.81987330
105regulation of translation, ncRNA-mediated (GO:0045974)2.81987330
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81580842
107negative regulation of epidermis development (GO:0045683)2.81506960
108DNA double-strand break processing (GO:0000729)2.80855563
109serotonin metabolic process (GO:0042428)2.79709402
110regulation of cell fate specification (GO:0042659)2.79581959
111positive regulation of membrane potential (GO:0045838)2.79566511
112atrial cardiac muscle cell action potential (GO:0086014)2.79540282
113mitochondrion distribution (GO:0048311)2.78540690
114L-serine metabolic process (GO:0006563)2.78135919
115dendrite morphogenesis (GO:0048813)2.77231761
116synapse organization (GO:0050808)2.77188530
117mechanosensory behavior (GO:0007638)2.73639041
118negative regulation of telomerase activity (GO:0051974)2.72709473
119DNA damage response, detection of DNA damage (GO:0042769)2.67587091
120chaperone-mediated protein transport (GO:0072321)2.65840434
121regulation of meiosis I (GO:0060631)2.63232159
122establishment of protein localization to mitochondrial membrane (GO:0090151)2.63148490
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58807599
124L-alpha-amino acid transmembrane transport (GO:1902475)2.58096148
125establishment of integrated proviral latency (GO:0075713)2.54157641
126chromatin remodeling at centromere (GO:0031055)2.53820213
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52171926
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.52171926
129negative regulation of gene silencing (GO:0060969)2.50399720
130inner ear receptor cell development (GO:0060119)2.49713978
131regulation of gene silencing (GO:0060968)2.48721846
132histone exchange (GO:0043486)2.48571852
133glycerophospholipid catabolic process (GO:0046475)2.47107528
134respiratory chain complex IV assembly (GO:0008535)2.45429716
135regulation of mitochondrial translation (GO:0070129)2.45301692
136ncRNA catabolic process (GO:0034661)2.43289249
137regulation of cell fate commitment (GO:0010453)2.40296468
138innervation (GO:0060384)2.40243591
139regulation of helicase activity (GO:0051095)2.39603021
140regulation of mesoderm development (GO:2000380)2.38487746
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.38155904
142nodal signaling pathway (GO:0038092)2.37441544
143protein complex biogenesis (GO:0070271)2.36159870
144DNA replication checkpoint (GO:0000076)2.34528080
145regulation of histone H3-K9 methylation (GO:0051570)2.34332969
146lung-associated mesenchyme development (GO:0060484)2.32537034
147mitochondrial respiratory chain complex assembly (GO:0033108)2.31824916
148CENP-A containing nucleosome assembly (GO:0034080)2.31387803
149DNA replication-dependent nucleosome organization (GO:0034723)2.27697757
150DNA replication-dependent nucleosome assembly (GO:0006335)2.27697757
151cytochrome complex assembly (GO:0017004)2.25460392
152positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.22474773
153positive regulation of neurotransmitter transport (GO:0051590)2.22172505
154regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.21413064
155regulation of mitotic spindle checkpoint (GO:1903504)2.21413064
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.21398353
157regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.18915633
158cell fate commitment involved in formation of primary germ layer (GO:0060795)2.17812657
159cochlea development (GO:0090102)2.15958375
160regulation of calcium ion-dependent exocytosis (GO:0017158)2.15109879
161nonmotile primary cilium assembly (GO:0035058)2.13329888
162positive regulation of histone H3-K4 methylation (GO:0051571)2.11422876
163retinal cone cell development (GO:0046549)2.10687021
164membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.10622257
165intraciliary transport (GO:0042073)2.10055992
166positive regulation of SMAD protein import into nucleus (GO:0060391)2.07093200
167exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.05887503
168regulation of neurotransmitter uptake (GO:0051580)2.05223234
169reflex (GO:0060004)2.05085497
170regulation of chromatin silencing (GO:0031935)2.04358904
171insulin secretion (GO:0030073)2.02792651
172mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.02640222
173inositol phosphate catabolic process (GO:0071545)2.02534664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60823462
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.35636157
3GBX2_23144817_ChIP-Seq_PC3_Human3.03333271
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95265106
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89006487
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88907772
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.82371030
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.82371030
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.82371030
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82300214
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74160764
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74160764
13REST_21632747_ChIP-Seq_MESCs_Mouse2.60638328
14ZNF274_21170338_ChIP-Seq_K562_Hela2.57360121
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56576716
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.48198968
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41496768
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35964229
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.34915904
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32921851
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28040051
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24576279
23FUS_26573619_Chip-Seq_HEK293_Human2.22878494
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18391332
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.16987234
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.11161451
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.10371714
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07879746
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06850810
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.04510775
31RNF2_27304074_Chip-Seq_NSC_Mouse2.03764294
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01526536
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97774994
34IGF1R_20145208_ChIP-Seq_DFB_Human1.97490872
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97453311
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93529583
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.92990820
38EWS_26573619_Chip-Seq_HEK293_Human1.92396787
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91028290
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.85972706
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85002479
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83778607
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79096548
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76791387
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64396216
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63996958
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.63985542
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.63978362
49DROSHA_22980978_ChIP-Seq_HELA_Human1.62773006
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62509848
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.58780751
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.58504680
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.58097627
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.57269556
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.55217831
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.54363362
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.53541544
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52299317
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45557447
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44431142
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.43876086
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.43440496
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.40480526
64E2F7_22180533_ChIP-Seq_HELA_Human1.40156363
65MYC_18940864_ChIP-ChIP_HL60_Human1.37353491
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36919649
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35851805
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35611199
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35363137
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34623170
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.34406791
72SMAD4_21799915_ChIP-Seq_A2780_Human1.30851391
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28339679
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26551333
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26475877
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25842334
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24759855
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24541710
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24454293
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24201469
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21839359
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.21532931
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20217943
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.19060804
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18974572
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18461509
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17527035
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17456377
89CBP_20019798_ChIP-Seq_JUKART_Human1.17456377
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14149085
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13531459
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13391761
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13353894
94MYC_18555785_ChIP-Seq_MESCs_Mouse1.12815701
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12803148
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.12092112
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11487114
98TP53_22573176_ChIP-Seq_HFKS_Human1.11360270
99AR_19668381_ChIP-Seq_PC3_Human1.11074272
100STAT3_23295773_ChIP-Seq_U87_Human1.10962047
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10619783
102E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10616487
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10340038
104AR_21572438_ChIP-Seq_LNCaP_Human1.09785984
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08838126
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.08153954
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08007450
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07802362
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07802362
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07715363
111TCF4_23295773_ChIP-Seq_U87_Human1.07045909
112SMAD3_21741376_ChIP-Seq_ESCs_Human1.06119814
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05555217
114E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04484524
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04260121
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03606502
117ELK1_19687146_ChIP-ChIP_HELA_Human1.03230331
118P300_19829295_ChIP-Seq_ESCs_Human1.03157202
119TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02850188
120AR_25329375_ChIP-Seq_VCAP_Human1.02776169
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02290519
122SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02285241
123IRF1_19129219_ChIP-ChIP_H3396_Human1.01987551
124ETS1_20019798_ChIP-Seq_JURKAT_Human1.01290067
125VDR_22108803_ChIP-Seq_LS180_Human1.00477684
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99188674
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98609150
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.97983592
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97398655
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97296495
131POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95532865
132KDM2B_26808549_Chip-Seq_K562_Human0.95368561
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95310550
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95160152
135AHR_22903824_ChIP-Seq_MCF-7_Human0.95021027
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.94957939
137TCF4_22108803_ChIP-Seq_LS180_Human0.94569762
138TAF15_26573619_Chip-Seq_HEK293_Human0.94545852
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92356699
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92177501
141ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91825625
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91689186
143SOX2_19829295_ChIP-Seq_ESCs_Human0.91634636
144NANOG_19829295_ChIP-Seq_ESCs_Human0.91634636
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.91506415
146DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90792115
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90722778
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90187261
149CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90062008
150BCAT_22108803_ChIP-Seq_LS180_Human0.89909100
151TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89761899
152TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89165801
153RUNX2_22187159_ChIP-Seq_PCA_Human0.89049592
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88939847
155SOX9_26525672_Chip-Seq_HEART_Mouse0.88772744
156YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87911722
157POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86760678
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86451486
159TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85354548
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.83989371
161PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83121649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.46247913
2MP0003880_abnormal_central_pattern4.23199141
3MP0003122_maternal_imprinting3.42888548
4MP0008877_abnormal_DNA_methylation3.36079266
5MP0003635_abnormal_synaptic_transmissio3.23499810
6MP0006292_abnormal_olfactory_placode3.02201355
7MP0009046_muscle_twitch2.99907117
8MP0005423_abnormal_somatic_nervous2.88030107
9MP0002063_abnormal_learning/memory/cond2.67909862
10MP0009745_abnormal_behavioral_response2.67099569
11MP0004858_abnormal_nervous_system2.66029735
12MP0002572_abnormal_emotion/affect_behav2.65146442
13MP0006276_abnormal_autonomic_nervous2.56526678
14MP0002064_seizures2.56227055
15MP0004270_analgesia2.55209349
16MP0001486_abnormal_startle_reflex2.55141764
17MP0005394_taste/olfaction_phenotype2.50432525
18MP0005499_abnormal_olfactory_system2.50432525
19MP0001501_abnormal_sleep_pattern2.20866363
20MP0002272_abnormal_nervous_system2.19818402
21MP0003787_abnormal_imprinting2.11902384
22MP0001968_abnormal_touch/_nociception2.10795337
23MP0002734_abnormal_mechanical_nocicepti2.09888227
24MP0002184_abnormal_innervation2.05086609
25MP0003890_abnormal_embryonic-extraembry1.95708779
26MP0001440_abnormal_grooming_behavior1.91158727
27MP0003121_genomic_imprinting1.87617613
28MP0000778_abnormal_nervous_system1.84433504
29MP0002733_abnormal_thermal_nociception1.79977819
30MP0005645_abnormal_hypothalamus_physiol1.77789914
31MP0002163_abnormal_gland_morphology1.77102897
32MP0002067_abnormal_sensory_capabilities1.76354017
33MP0004142_abnormal_muscle_tone1.68737562
34MP0002557_abnormal_social/conspecific_i1.65682350
35MP0003011_delayed_dark_adaptation1.63938180
36MP0002837_dystrophic_cardiac_calcinosis1.60346908
37MP0001970_abnormal_pain_threshold1.57230719
38MP0005379_endocrine/exocrine_gland_phen1.52856151
39MP0001293_anophthalmia1.52611298
40MP0000955_abnormal_spinal_cord1.50827424
41MP0002938_white_spotting1.50792905
42MP0002735_abnormal_chemical_nociception1.50071226
43MP0008961_abnormal_basal_metabolism1.48528342
44MP0002736_abnormal_nociception_after1.46205688
45MP0002909_abnormal_adrenal_gland1.45660175
46MP0003567_abnormal_fetal_cardiomyocyte1.43668762
47MP0003938_abnormal_ear_development1.43505862
48MP0008058_abnormal_DNA_repair1.42735710
49MP0002254_reproductive_system_inflammat1.41835272
50MP0003119_abnormal_digestive_system1.39887266
51MP0005386_behavior/neurological_phenoty1.39130232
52MP0004924_abnormal_behavior1.39130232
53MP0002332_abnormal_exercise_endurance1.35820234
54MP0005257_abnormal_intraocular_pressure1.33716330
55MP0001529_abnormal_vocalization1.32772163
56MP0003718_maternal_effect1.32724093
57MP0002882_abnormal_neuron_morphology1.31773062
58MP0001905_abnormal_dopamine_level1.31010696
59MP0001485_abnormal_pinna_reflex1.27392873
60MP0008569_lethality_at_weaning1.26917520
61MP0003693_abnormal_embryo_hatching1.25936955
62MP0004811_abnormal_neuron_physiology1.25752651
63MP0002066_abnormal_motor_capabilities/c1.19329365
64MP0001984_abnormal_olfaction1.18995569
65MP0003937_abnormal_limbs/digits/tail_de1.17739951
66MP0004885_abnormal_endolymph1.17107062
67MP0004147_increased_porphyrin_level1.16881882
68MP0000372_irregular_coat_pigmentation1.16603595
69MP0003137_abnormal_impulse_conducting1.13566313
70MP0003195_calcinosis1.13430362
71MP0002822_catalepsy1.13113502
72MP0005075_abnormal_melanosome_morpholog1.12242595
73MP0009672_abnormal_birth_weight1.11914102
74MP0003123_paternal_imprinting1.11902524
75MP0002277_abnormal_respiratory_mucosa1.11487903
76MP0001188_hyperpigmentation1.11037491
77MP0003878_abnormal_ear_physiology1.10482783
78MP0005377_hearing/vestibular/ear_phenot1.10482783
79MP0002752_abnormal_somatic_nervous1.10044227
80MP0003183_abnormal_peptide_metabolism1.09520684
81MP0003941_abnormal_skin_development1.09170836
82MP0005646_abnormal_pituitary_gland1.08257899
83MP0008057_abnormal_DNA_replication1.07883401
84MP0006035_abnormal_mitochondrial_morpho1.06345492
85MP0000631_abnormal_neuroendocrine_gland1.06045831
86MP0008872_abnormal_physiological_respon1.06014420
87MP0004742_abnormal_vestibular_system1.05276185
88MP0004957_abnormal_blastocyst_morpholog1.03933519
89MP0002152_abnormal_brain_morphology1.03395152
90MP0001963_abnormal_hearing_physiology1.01469432
91MP0003879_abnormal_hair_cell1.01412940
92MP0002160_abnormal_reproductive_system1.00734135
93MP0000678_abnormal_parathyroid_gland0.99957135
94MP0002090_abnormal_vision0.98297921
95MP0010094_abnormal_chromosome_stability0.98158755
96MP0000569_abnormal_digit_pigmentation0.97628596
97MP0001348_abnormal_lacrimal_gland0.95475908
98MP0010386_abnormal_urinary_bladder0.94644107
99MP0008789_abnormal_olfactory_epithelium0.93906733
100MP0005551_abnormal_eye_electrophysiolog0.92851872
101MP0003283_abnormal_digestive_organ0.92404872
102MP0001299_abnormal_eye_distance/0.91891390
103MP0005084_abnormal_gallbladder_morpholo0.91403947
104MP0002653_abnormal_ependyma_morphology0.91295756
105MP0004264_abnormal_extraembryonic_tissu0.90416278
106MP0003861_abnormal_nervous_system0.89282543
107MP0004133_heterotaxia0.89192364
108MP0000026_abnormal_inner_ear0.88219388
109MP0003698_abnormal_male_reproductive0.85576275
110MP0005253_abnormal_eye_physiology0.85341079
111MP0002751_abnormal_autonomic_nervous0.85274427
112MP0000049_abnormal_middle_ear0.85143735
113MP0002229_neurodegeneration0.85098593
114MP0002210_abnormal_sex_determination0.83988659
115MP0002233_abnormal_nose_morphology0.83070940
116MP0004085_abnormal_heartbeat0.82529276
117MP0002697_abnormal_eye_size0.78800880
118MP0001502_abnormal_circadian_rhythm0.77944701
119MP0002234_abnormal_pharynx_morphology0.77333819
120MP0004043_abnormal_pH_regulation0.77055131
121MP0004145_abnormal_muscle_electrophysio0.76904365
122MP0009780_abnormal_chondrocyte_physiolo0.76594678
123MP0002069_abnormal_eating/drinking_beha0.75951977
124MP0003136_yellow_coat_color0.74969171
125MP0003632_abnormal_nervous_system0.69556809
126MP0002102_abnormal_ear_morphology0.69119730
127MP0006072_abnormal_retinal_apoptosis0.68819296
128MP0002127_abnormal_cardiovascular_syste0.66044867
129MP0003329_amyloid_beta_deposits0.65098857
130MP0002081_perinatal_lethality0.63383867
131MP0002114_abnormal_axial_skeleton0.63304902
132MP0003633_abnormal_nervous_system0.63079588
133MP0002638_abnormal_pupillary_reflex0.62236199

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.22759009
2Focal motor seizures (HP:0011153)5.17519322
3Focal seizures (HP:0007359)4.44609976
4Abnormality of the lower motor neuron (HP:0002366)4.37413432
5Febrile seizures (HP:0002373)4.32678058
6Epileptic encephalopathy (HP:0200134)4.20213291
7Hyperventilation (HP:0002883)4.15398094
8Hepatoblastoma (HP:0002884)4.06930976
9Visual hallucinations (HP:0002367)3.88905999
10Myokymia (HP:0002411)3.63450187
11Progressive cerebellar ataxia (HP:0002073)3.62589715
12Amyotrophic lateral sclerosis (HP:0007354)3.53797719
13Colon cancer (HP:0003003)3.43784239
14Horizontal nystagmus (HP:0000666)3.43747722
15Dialeptic seizures (HP:0011146)3.43591041
16Atonic seizures (HP:0010819)3.40354110
17Hypochromic microcytic anemia (HP:0004840)3.36484105
18Absence seizures (HP:0002121)3.26583413
19Hyperinsulinemic hypoglycemia (HP:0000825)3.08345527
20Amblyopia (HP:0000646)3.07675316
21Generalized tonic-clonic seizures (HP:0002069)3.04242176
22Hypoglycemic seizures (HP:0002173)2.96323968
23Hemiparesis (HP:0001269)2.95426215
24Septo-optic dysplasia (HP:0100842)2.93656955
25Excessive salivation (HP:0003781)2.74773494
26Drooling (HP:0002307)2.74773494
27Rib fusion (HP:0000902)2.72479034
28Broad-based gait (HP:0002136)2.65118236
29Action tremor (HP:0002345)2.63492790
30Abnormality of the corticospinal tract (HP:0002492)2.63254224
31Intestinal atresia (HP:0011100)2.59867414
32Hypoplasia of the fovea (HP:0007750)2.53256388
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.53256388
34Generalized hypotonia (HP:0001290)2.52904213
35Bifid tongue (HP:0010297)2.49115908
36Optic nerve hypoplasia (HP:0000609)2.44565730
37Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.42572835
38Absent speech (HP:0001344)2.40466306
39Hypoglycemic coma (HP:0001325)2.40368632
40Pancreatic cysts (HP:0001737)2.33496250
41Status epilepticus (HP:0002133)2.31528533
42Dysdiadochokinesis (HP:0002075)2.30841464
43Ependymoma (HP:0002888)2.30756967
44Hyperglycinemia (HP:0002154)2.29584759
45Supranuclear gaze palsy (HP:0000605)2.29471082
46Gait imbalance (HP:0002141)2.28680977
47Inability to walk (HP:0002540)2.28388748
48Nephroblastoma (Wilms tumor) (HP:0002667)2.28055686
49Failure to thrive in infancy (HP:0001531)2.26577897
50Astrocytoma (HP:0009592)2.23615824
51Abnormality of the astrocytes (HP:0100707)2.23615824
52Medial flaring of the eyebrow (HP:0010747)2.23550808
53Anomalous pulmonary venous return (HP:0010772)2.23546016
54Pancreatic fibrosis (HP:0100732)2.23342772
55Aqueductal stenosis (HP:0002410)2.22401261
56Partial duplication of thumb phalanx (HP:0009944)2.22177827
57Pancreatic islet-cell hyperplasia (HP:0004510)2.19445527
58Neoplasm of the heart (HP:0100544)2.18455755
59Neoplasm of the adrenal cortex (HP:0100641)2.18140059
60Mutism (HP:0002300)2.15617899
61Vaginal atresia (HP:0000148)2.14377249
62Genital tract atresia (HP:0001827)2.13328061
63Embryonal renal neoplasm (HP:0011794)2.11751942
64Nephronophthisis (HP:0000090)2.11369078
65Testicular atrophy (HP:0000029)2.10300390
66Abnormality of the pancreatic islet cells (HP:0006476)2.08449823
67Abnormality of endocrine pancreas physiology (HP:0012093)2.08449823
68Oligodactyly (hands) (HP:0001180)2.07399465
69Tetraplegia (HP:0002445)2.05461661
70Congenital primary aphakia (HP:0007707)2.03898731
71Depression (HP:0000716)2.03815018
72Epileptiform EEG discharges (HP:0011182)2.03301122
73Hyperglycinuria (HP:0003108)2.02240893
74Abnormality of the fovea (HP:0000493)2.02117832
75Acute necrotizing encephalopathy (HP:0006965)2.01886769
76Open mouth (HP:0000194)2.00991794
77True hermaphroditism (HP:0010459)1.99385628
78Increased hepatocellular lipid droplets (HP:0006565)1.98894373
79Abnormality of abdominal situs (HP:0011620)1.98118802
80Abdominal situs inversus (HP:0003363)1.98118802
81Lipid accumulation in hepatocytes (HP:0006561)1.98006015
82Neoplasm of striated muscle (HP:0009728)1.96760477
83Genetic anticipation (HP:0003743)1.96540097
84EEG with generalized epileptiform discharges (HP:0011198)1.96464052
85Protruding tongue (HP:0010808)1.94901752
86Pendular nystagmus (HP:0012043)1.94704852
87Abnormality of the pubic bones (HP:0003172)1.94428924
88Hypsarrhythmia (HP:0002521)1.93092673
89Gaze-evoked nystagmus (HP:0000640)1.91239081
90Limb dystonia (HP:0002451)1.89502528
91Abnormality of the pulmonary veins (HP:0011718)1.88884861
92Abnormality of glycine metabolism (HP:0010895)1.88500456
93Abnormality of serine family amino acid metabolism (HP:0010894)1.88500456
94Poor eye contact (HP:0000817)1.88380606
95Maternal diabetes (HP:0009800)1.87482426
96Partial duplication of the phalanx of hand (HP:0009999)1.87091431
97Acute encephalopathy (HP:0006846)1.86359374
98Nephrogenic diabetes insipidus (HP:0009806)1.85935661
99Dysmetria (HP:0001310)1.85703292
100Nasolacrimal duct obstruction (HP:0000579)1.84978487
101Abnormality of the labia minora (HP:0012880)1.84775149
102Generalized myoclonic seizures (HP:0002123)1.84619017
103Broad foot (HP:0001769)1.84034491
104Labial hypoplasia (HP:0000066)1.83590263
105Absent septum pellucidum (HP:0001331)1.83435097
106Dyschromatopsia (HP:0007641)1.82961358
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82754314
108Type II lissencephaly (HP:0007260)1.82472381
109Molar tooth sign on MRI (HP:0002419)1.82389058
110Abnormality of midbrain morphology (HP:0002418)1.82389058
111Abnormal eating behavior (HP:0100738)1.80197347
112Gastrointestinal atresia (HP:0002589)1.79908515
113Progressive macrocephaly (HP:0004481)1.79361076
114Abnormal hair whorl (HP:0010721)1.79089010
115Abnormality of ocular smooth pursuit (HP:0000617)1.78930673
116Poor suck (HP:0002033)1.76960371
117Rectovaginal fistula (HP:0000143)1.76042879
118Rectal fistula (HP:0100590)1.76042879
119Hypoplastic female external genitalia (HP:0012815)1.75208793
120Hypogonadotrophic hypogonadism (HP:0000044)1.75048403
121Tented upper lip vermilion (HP:0010804)1.74692261
122Meckel diverticulum (HP:0002245)1.74378318
123Ankle clonus (HP:0011448)1.74135432
124Sensory axonal neuropathy (HP:0003390)1.73764743
125Absent eyebrow (HP:0002223)1.73707019
126Sclerocornea (HP:0000647)1.73506294
127Ketoacidosis (HP:0001993)1.73473288
128Abnormality of the ileum (HP:0001549)1.72496621
129Shawl scrotum (HP:0000049)1.72368754
130Abnormality of the salivary glands (HP:0010286)1.71209055
131Poor coordination (HP:0002370)1.71015120
132Abnormality of chromosome segregation (HP:0002916)1.70932201
133Periauricular skin pits (HP:0100277)1.70865448
134Preauricular pit (HP:0004467)1.70865448
135Abnormality of the lacrimal duct (HP:0011481)1.68991434
136Chronic hepatic failure (HP:0100626)1.68959709
137Malignant neoplasm of the central nervous system (HP:0100836)1.68886204
138Polyphagia (HP:0002591)1.68640717
139Abnormality of salivation (HP:0100755)1.68628676
140Renal duplication (HP:0000075)1.68235116
141Abnormality of the metopic suture (HP:0005556)1.67659982
142Abnormality of the septum pellucidum (HP:0007375)1.67503482
143Hypomagnesemia (HP:0002917)1.66812076
144Symptomatic seizures (HP:0011145)1.66745676
145Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66635397
146Progressive external ophthalmoplegia (HP:0000590)1.66326014
147Increased CSF lactate (HP:0002490)1.66157748
148Impaired social interactions (HP:0000735)1.66138417
149Abnormal social behavior (HP:0012433)1.66138417
150Macroglossia (HP:0000158)1.65802687
151Anencephaly (HP:0002323)1.65677897
152Diplopia (HP:0000651)1.65351411
153Abnormality of binocular vision (HP:0011514)1.65351411
154Carpal bone hypoplasia (HP:0001498)1.65156047
155Abnormal mitochondria in muscle tissue (HP:0008316)1.65104823
156Abnormality of the phalanges of the hallux (HP:0010057)1.64999838
157Bradykinesia (HP:0002067)1.64478919
158Methylmalonic acidemia (HP:0002912)1.64426946
159Mitochondrial inheritance (HP:0001427)1.64403382
160Lissencephaly (HP:0001339)1.63876187
161Specific learning disability (HP:0001328)1.63823624
162Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.63161281
163Aplasia/hypoplasia of the uterus (HP:0008684)1.62877920
164Glioma (HP:0009733)1.62427549
165Cerebellar dysplasia (HP:0007033)1.62365708
166Enlarged penis (HP:0000040)1.62113705
167Anophthalmia (HP:0000528)1.61222242
168Abnormality of the renal medulla (HP:0100957)1.61004702
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60658444
170Scrotal hypoplasia (HP:0000046)1.60231307
171Spastic tetraparesis (HP:0001285)1.59885375
172Abnormal ciliary motility (HP:0012262)1.59882177
173Truncal ataxia (HP:0002078)1.59673250
174Supernumerary spleens (HP:0009799)1.59376250
175Atrophy/Degeneration involving motor neurons (HP:0007373)1.59347627
176Deeply set eye (HP:0000490)1.59258232
177Humeroradial synostosis (HP:0003041)1.59029023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK54.52240840
2CDK123.90650631
3NTRK33.71536804
4MARK13.30997075
5FRK2.72585049
6MAP3K92.67306892
7ADRBK22.66648849
8MAP2K42.56504764
9MAP3K42.51348875
10GRK62.49129977
11NTRK22.41315342
12TYRO32.20746381
13MAP2K72.16524152
14CDC72.11536733
15EPHA42.08536192
16GRK12.05865818
17MINK12.05795392
18GRK72.02880676
19CASK2.02022641
20MAP3K122.00820812
21ZAK1.98057071
22NTRK11.88910833
23TAF11.77783170
24WNK11.76103784
25PINK11.75712050
26MKNK21.75004785
27PLK31.68607996
28FGFR21.67823160
29STK38L1.67493155
30BMPR1B1.66580746
31TSSK61.63878213
32TRIM281.59334824
33PAK61.54044165
34SIK21.52364172
35MKNK11.50104846
36SIK31.48129564
37MAP4K21.46047311
38SRPK11.42008165
39CSNK1G11.40097937
40MAPK131.38781590
41MARK21.36597081
42PASK1.31978471
43NUAK11.28680622
44LATS21.28281790
45CAMK41.26296506
46CSNK1G31.22461045
47PRKCG1.19655563
48CAMK1G1.18261105
49RIPK41.15419184
50AKT31.14583085
51TNIK1.13653990
52MAPK71.13107488
53PRPF4B1.12532881
54WNK41.12438471
55VRK21.12295513
56STK381.11635361
57CDK51.07659612
58CDK191.06307993
59MATK1.06279265
60STK31.03986708
61PNCK1.03795756
62UHMK11.02893027
63CAMK1D1.01722010
64CSF1R1.01338607
65MOS1.00914303
66INSRR1.00703489
67STK160.97188523
68ALK0.96879235
69ADRBK10.96857260
70PLK20.95538922
71BUB10.94595731
72PLK40.94585213
73EIF2AK30.93253712
74KSR10.93114482
75CSNK1A1L0.93107295
76PRKCE0.88613487
77PLK10.87553091
78DAPK20.86799894
79CDK180.84552246
80DYRK1A0.84427981
81TTK0.83771832
82NLK0.83288761
83PHKG20.82117508
84PHKG10.82117508
85CDK150.80625200
86VRK10.78489808
87DYRK30.78383117
88CAMK2A0.77408760
89CAMK10.76826044
90DAPK10.75189407
91DYRK20.73726227
92CDK140.73238941
93MST40.72045514
94ATM0.70442363
95CDK11A0.70333435
96PRKG20.69659489
97FES0.66546706
98FGFR10.64495350
99PAK30.64375614
100CAMKK10.64301917
101LATS10.64017585
102NEK20.63440182
103CSNK1A10.62723757
104ACVR1B0.62482552
105BRSK10.60722195
106MAP2K60.60658064
107BCR0.59683309
108MAPK120.59572637
109MAPK100.58428233
110ATR0.57277037
111OXSR10.54460504
112MAP3K70.53988464
113STK390.53696766
114HIPK20.53626908
115PRKDC0.53189565
116WNK30.53058706
117SGK4940.52550818
118SGK2230.52550818
119ERN10.51830075
120CSNK1D0.50776339
121FGFR30.48797540
122TIE10.48355351
123CDK30.48175899
124NEK10.47347322
125STK110.47304774
126PRKCH0.47112600
127SGK20.46507379
128TNK20.45466566
129RPS6KA30.45404921
130BRSK20.44980247
131AKT20.44295675
132BMPR20.44272774
133CAMK2B0.43692341
134CHEK20.43057101
135PRKACA0.42491983
136TGFBR20.42369948
137CSNK1E0.42210848
138SGK10.41303362
139NME10.40310302
140MAP3K100.39352432
141CSNK1G20.39246482
142DAPK30.38846338
143PRKACB0.37806107
144ERBB30.35455600
145PRKD30.35103156
146PKN10.34253386
147CAMKK20.33737855
148PRKACG0.33381327
149GSK3B0.33267018
150FYN0.31526300
151CDC42BPA0.30276408
152NEK60.28838519
153PRKCZ0.27982676
154PRKG10.27276223

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.43031132
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02209435
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.00434449
4GABAergic synapse_Homo sapiens_hsa047272.97792269
5Glutamatergic synapse_Homo sapiens_hsa047242.81852045
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62383285
7Long-term potentiation_Homo sapiens_hsa047202.44217566
8Taste transduction_Homo sapiens_hsa047422.36630056
9Circadian entrainment_Homo sapiens_hsa047132.36175529
10Morphine addiction_Homo sapiens_hsa050322.33855537
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33042374
12Protein export_Homo sapiens_hsa030602.27660666
13Serotonergic synapse_Homo sapiens_hsa047262.23122754
14Oxidative phosphorylation_Homo sapiens_hsa001902.15879857
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.15479759
16Olfactory transduction_Homo sapiens_hsa047402.08965587
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08197845
18Amphetamine addiction_Homo sapiens_hsa050312.06880986
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02721368
20Salivary secretion_Homo sapiens_hsa049702.01779775
21Dopaminergic synapse_Homo sapiens_hsa047282.01591299
22Long-term depression_Homo sapiens_hsa047301.97403604
23Basal transcription factors_Homo sapiens_hsa030221.88300711
24Selenocompound metabolism_Homo sapiens_hsa004501.81174781
25Vitamin B6 metabolism_Homo sapiens_hsa007501.78269649
26Parkinsons disease_Homo sapiens_hsa050121.76403051
27RNA polymerase_Homo sapiens_hsa030201.75330429
28Non-homologous end-joining_Homo sapiens_hsa034501.65514686
29Calcium signaling pathway_Homo sapiens_hsa040201.65218771
30Butanoate metabolism_Homo sapiens_hsa006501.64131073
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59194199
32Mismatch repair_Homo sapiens_hsa034301.56473626
33Insulin secretion_Homo sapiens_hsa049111.56003960
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.55334109
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53906966
36Renin secretion_Homo sapiens_hsa049241.51569420
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50255391
38Cholinergic synapse_Homo sapiens_hsa047251.49927828
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49496755
40RNA degradation_Homo sapiens_hsa030181.46879516
41Cocaine addiction_Homo sapiens_hsa050301.46737197
42Oxytocin signaling pathway_Homo sapiens_hsa049211.45708553
43Propanoate metabolism_Homo sapiens_hsa006401.45370366
44RNA transport_Homo sapiens_hsa030131.42230587
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39937024
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.39827702
47Axon guidance_Homo sapiens_hsa043601.39507586
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39192277
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39124368
50Huntingtons disease_Homo sapiens_hsa050161.38500981
51Gastric acid secretion_Homo sapiens_hsa049711.34508324
52Ribosome_Homo sapiens_hsa030101.33911925
53Homologous recombination_Homo sapiens_hsa034401.33421150
54Collecting duct acid secretion_Homo sapiens_hsa049661.33234664
55GnRH signaling pathway_Homo sapiens_hsa049121.32977296
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29791764
57cAMP signaling pathway_Homo sapiens_hsa040241.23931037
58Fanconi anemia pathway_Homo sapiens_hsa034601.23823207
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23259815
60Gap junction_Homo sapiens_hsa045401.21441779
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18386079
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17615627
63Steroid biosynthesis_Homo sapiens_hsa001001.16329728
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13042269
65Phototransduction_Homo sapiens_hsa047441.12726085
66Cardiac muscle contraction_Homo sapiens_hsa042601.12283919
67Proteasome_Homo sapiens_hsa030501.09784075
68Phospholipase D signaling pathway_Homo sapiens_hsa040721.07283056
69Spliceosome_Homo sapiens_hsa030401.06844473
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04283661
71One carbon pool by folate_Homo sapiens_hsa006701.03921182
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03586032
73Choline metabolism in cancer_Homo sapiens_hsa052311.00698384
74DNA replication_Homo sapiens_hsa030300.99498272
75beta-Alanine metabolism_Homo sapiens_hsa004100.94228226
76Melanogenesis_Homo sapiens_hsa049160.92545660
77Folate biosynthesis_Homo sapiens_hsa007900.91380760
78Pyruvate metabolism_Homo sapiens_hsa006200.90903638
79ErbB signaling pathway_Homo sapiens_hsa040120.90676740
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90113296
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.88014761
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87491551
83Inositol phosphate metabolism_Homo sapiens_hsa005620.86315389
84Base excision repair_Homo sapiens_hsa034100.85743018
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85598535
86Estrogen signaling pathway_Homo sapiens_hsa049150.82917184
87Fructose and mannose metabolism_Homo sapiens_hsa000510.82587327
88Purine metabolism_Homo sapiens_hsa002300.81222362
89Ovarian steroidogenesis_Homo sapiens_hsa049130.80873422
90Tight junction_Homo sapiens_hsa045300.80344287
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79891476
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78282991
93mTOR signaling pathway_Homo sapiens_hsa041500.77555267
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76324775
95Type II diabetes mellitus_Homo sapiens_hsa049300.75132612
96Regulation of autophagy_Homo sapiens_hsa041400.74239991
97Wnt signaling pathway_Homo sapiens_hsa043100.72650962
98MAPK signaling pathway_Homo sapiens_hsa040100.71935459
99Oocyte meiosis_Homo sapiens_hsa041140.71378319
100Fatty acid elongation_Homo sapiens_hsa000620.71047849
101Glioma_Homo sapiens_hsa052140.70037583
102Ras signaling pathway_Homo sapiens_hsa040140.69950172
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69619541
104Tryptophan metabolism_Homo sapiens_hsa003800.69547286
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69395761
106Dorso-ventral axis formation_Homo sapiens_hsa043200.68516138
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68272784
108Hedgehog signaling pathway_Homo sapiens_hsa043400.66246963
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65237250
110Rap1 signaling pathway_Homo sapiens_hsa040150.65040151
111Dilated cardiomyopathy_Homo sapiens_hsa054140.64928790
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64599842
113Vibrio cholerae infection_Homo sapiens_hsa051100.63343233
114Metabolic pathways_Homo sapiens_hsa011000.61474408
115Arginine and proline metabolism_Homo sapiens_hsa003300.60387006
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60261100
117Cell cycle_Homo sapiens_hsa041100.59803036
118Pyrimidine metabolism_Homo sapiens_hsa002400.58941501
119Nucleotide excision repair_Homo sapiens_hsa034200.57563928
120Fatty acid metabolism_Homo sapiens_hsa012120.55142747
121Linoleic acid metabolism_Homo sapiens_hsa005910.54974675
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54751561
123African trypanosomiasis_Homo sapiens_hsa051430.53337268
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52899296
125Circadian rhythm_Homo sapiens_hsa047100.52827174
126Peroxisome_Homo sapiens_hsa041460.51569074
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51188780
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.49713215
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49482613
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46531901
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45053000
132Nitrogen metabolism_Homo sapiens_hsa009100.44258121
133Alcoholism_Homo sapiens_hsa050340.42922427
134Pancreatic secretion_Homo sapiens_hsa049720.42512598
135Basal cell carcinoma_Homo sapiens_hsa052170.42501018
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42484332
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42418389
138Thyroid hormone synthesis_Homo sapiens_hsa049180.41729092
139Ether lipid metabolism_Homo sapiens_hsa005650.41396706
140VEGF signaling pathway_Homo sapiens_hsa043700.40195892
141Type I diabetes mellitus_Homo sapiens_hsa049400.40003518
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.39738505
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.38806446
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38299471
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38157144
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36929045
147Alzheimers disease_Homo sapiens_hsa050100.36853447
148mRNA surveillance pathway_Homo sapiens_hsa030150.35218469
149Non-small cell lung cancer_Homo sapiens_hsa052230.34489783
150Arachidonic acid metabolism_Homo sapiens_hsa005900.33894379
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33547642
152Galactose metabolism_Homo sapiens_hsa000520.32771426
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32079985
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31386672
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30923775
156Hippo signaling pathway_Homo sapiens_hsa043900.30552167
157Endometrial cancer_Homo sapiens_hsa052130.23872430
158Endocytosis_Homo sapiens_hsa041440.23703154
159Colorectal cancer_Homo sapiens_hsa052100.23594509

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