TUSC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.74541108
2neutrophil activation involved in immune response (GO:0002283)5.04618284
3ribosomal small subunit assembly (GO:0000028)5.02585384
4positive regulation by symbiont of host defense response (GO:0052509)4.62732506
5modulation by symbiont of host defense response (GO:0052031)4.62732506
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62732506
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62732506
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.62732506
9modulation by symbiont of host immune response (GO:0052553)4.62732506
10viral transcription (GO:0019083)4.60096927
11translational termination (GO:0006415)4.37360355
12antigen processing and presentation via MHC class Ib (GO:0002475)4.22475765
13glycoside metabolic process (GO:0016137)4.21166012
14respiratory burst (GO:0045730)4.11347059
15Arp2/3 complex-mediated actin nucleation (GO:0034314)4.01204466
16outer ear morphogenesis (GO:0042473)3.93362841
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.92519689
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87815282
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87815282
20DNA deamination (GO:0045006)3.86358076
21protein targeting to ER (GO:0045047)3.83954186
22kidney mesenchyme development (GO:0072074)3.81250463
23cotranslational protein targeting to membrane (GO:0006613)3.80580891
24translational elongation (GO:0006414)3.77459527
25production of molecular mediator involved in inflammatory response (GO:0002532)3.76565110
26cellular response to zinc ion (GO:0071294)3.75605585
27lipopolysaccharide biosynthetic process (GO:0009103)3.67238348
28lipopolysaccharide metabolic process (GO:0008653)3.66665680
29negative regulation of erythrocyte differentiation (GO:0045647)3.66096217
30regulation of glucocorticoid metabolic process (GO:0031943)3.65994396
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.63045908
32protein localization to endoplasmic reticulum (GO:0070972)3.62383463
33lymph vessel development (GO:0001945)3.61427136
34heme biosynthetic process (GO:0006783)3.57379474
35positive regulation of B cell differentiation (GO:0045579)3.53475516
36response to interferon-beta (GO:0035456)3.48719196
37immunoglobulin mediated immune response (GO:0016064)3.48411205
38phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.39345531
39ribosomal small subunit biogenesis (GO:0042274)3.35636609
40protein heterotrimerization (GO:0070208)3.35318062
41embryonic skeletal joint morphogenesis (GO:0060272)3.34504519
42erythrocyte maturation (GO:0043249)3.32939542
43megakaryocyte development (GO:0035855)3.32455874
44macrophage activation involved in immune response (GO:0002281)3.27901003
45cellular response to thyroid hormone stimulus (GO:0097067)3.25760982
46viral life cycle (GO:0019058)3.25563951
47response to host immune response (GO:0052572)3.25505281
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25505281
49regulation of interferon-beta biosynthetic process (GO:0045357)3.25416427
50response to peptidoglycan (GO:0032494)3.24103575
51CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.23666656
52cellular protein complex disassembly (GO:0043624)3.23612732
53heme metabolic process (GO:0042168)3.21354874
54antigen processing and presentation of endogenous antigen (GO:0019883)3.21301717
55response to interferon-alpha (GO:0035455)3.18090612
56defense response to protozoan (GO:0042832)3.15009915
57regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14076935
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13937831
59regulation of erythrocyte differentiation (GO:0045646)3.13863001
60endothelium development (GO:0003158)3.11913983
61execution phase of apoptosis (GO:0097194)3.10312624
62definitive hemopoiesis (GO:0060216)3.08026208
63desmosome organization (GO:0002934)3.07829025
64embryonic heart tube development (GO:0035050)3.06330292
65regulation of T-helper 1 cell differentiation (GO:0045625)3.04793790
66endosome to melanosome transport (GO:0035646)3.04670712
67endosome to pigment granule transport (GO:0043485)3.04670712
68regulation of apoptotic process involved in morphogenesis (GO:1902337)3.03936497
69adenine nucleotide transport (GO:0051503)3.03061496
70NIK/NF-kappaB signaling (GO:0038061)3.02868150
71regulation of glomerular filtration (GO:0003093)3.02723093
72angiogenesis involved in wound healing (GO:0060055)3.00241350
73response to type I interferon (GO:0034340)3.00018625
74reactive oxygen species biosynthetic process (GO:1903409)2.99303271
75myeloid dendritic cell differentiation (GO:0043011)2.98722549
76metanephric mesenchyme development (GO:0072075)2.97155618
77hydrogen peroxide biosynthetic process (GO:0050665)2.96981181
78translational initiation (GO:0006413)2.96916244
79cellular response to type I interferon (GO:0071357)2.96568121
80type I interferon signaling pathway (GO:0060337)2.96568121
81establishment of tissue polarity (GO:0007164)2.96019213
82establishment of planar polarity (GO:0001736)2.96019213
83middle ear morphogenesis (GO:0042474)2.95941746
84neutrophil activation (GO:0042119)2.95505914
85granulocyte activation (GO:0036230)2.95434602
86leukocyte degranulation (GO:0043299)2.93922331
87porphyrin-containing compound biosynthetic process (GO:0006779)2.92801575
88response to host (GO:0075136)2.92393574
89response to host defenses (GO:0052200)2.92393574
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92393574
91regulation of necroptotic process (GO:0060544)2.92056120
92seminiferous tubule development (GO:0072520)2.91572206
93cell migration involved in heart development (GO:0060973)2.91471363
94response to fungus (GO:0009620)2.91178535
95response to protozoan (GO:0001562)2.90973909
963-UTR-mediated mRNA stabilization (GO:0070935)2.89900511
97cellular response to arsenic-containing substance (GO:0071243)2.89528248
98protein complex disassembly (GO:0043241)2.87241717
99myeloid cell activation involved in immune response (GO:0002275)2.86194017
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85069474
101myeloid dendritic cell activation (GO:0001773)2.82735957
102positive regulation of gamma-delta T cell activation (GO:0046645)2.81572058
103negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.81011977
104lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78789773
105proximal/distal pattern formation (GO:0009954)2.78484379
106response to thyroid hormone (GO:0097066)2.78402701
107response to muramyl dipeptide (GO:0032495)2.77396061
108actin nucleation (GO:0045010)2.76485860
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76204944
110positive regulation of odontogenesis (GO:0042482)2.75484967
111protoporphyrinogen IX metabolic process (GO:0046501)2.75324201
112extracellular fibril organization (GO:0043206)2.73826304
113regulation of B cell differentiation (GO:0045577)2.72657203
114heart trabecula formation (GO:0060347)2.71699562
115peptidyl-proline hydroxylation (GO:0019511)2.71483810
116positive regulation of interferon-alpha production (GO:0032727)2.71236135
117T cell apoptotic process (GO:0070231)2.68781027
118macromolecular complex disassembly (GO:0032984)2.67692863
119protein retention in ER lumen (GO:0006621)2.67196680
120N-acetylneuraminate metabolic process (GO:0006054)2.67016530
121diaphragm development (GO:0060539)2.65490023
122protein targeting to membrane (GO:0006612)2.64939044
123positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.63795526
124fusion of sperm to egg plasma membrane (GO:0007342)2.62720053
125cellular response to interferon-beta (GO:0035458)2.62100009
126regulation of early endosome to late endosome transport (GO:2000641)2.62087546
127purine ribonucleotide transport (GO:0015868)2.60273771
128activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.58694404
129mature B cell differentiation (GO:0002335)2.58681066
130granulocyte differentiation (GO:0030851)2.58221129
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58150563
132positive regulation of actin filament depolymerization (GO:0030836)2.57951281
133cochlea morphogenesis (GO:0090103)2.57689622
134epithelial cell maturation (GO:0002070)2.56407364
135vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.56286251
136endocardial cushion morphogenesis (GO:0003203)2.54861826
137organ induction (GO:0001759)2.54302062
138prostaglandin biosynthetic process (GO:0001516)2.50655028
139prostanoid biosynthetic process (GO:0046457)2.50655028
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49287680
141hemidesmosome assembly (GO:0031581)2.48999785
142skeletal muscle organ development (GO:0060538)2.44790528
143embryonic forelimb morphogenesis (GO:0035115)2.44364247
144pattern specification involved in kidney development (GO:0061004)2.43132908
145virion attachment to host cell (GO:0019062)2.40883861
146adhesion of symbiont to host cell (GO:0044650)2.40883861
147muscle cell fate commitment (GO:0042693)2.40178316
148purine nucleotide transport (GO:0015865)2.40161884
149positive regulation of p38MAPK cascade (GO:1900745)2.39644796
150outflow tract septum morphogenesis (GO:0003148)2.38845095
151regulation of organ formation (GO:0003156)2.36796093
152epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.35076633
153Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34920326
154gap junction assembly (GO:0016264)2.34612323
155pharyngeal system development (GO:0060037)2.34501018
156collagen fibril organization (GO:0030199)2.34323013
157morphogenesis of embryonic epithelium (GO:0016331)2.31937119
158endothelial cell chemotaxis (GO:0035767)2.27830638
159lateral sprouting from an epithelium (GO:0060601)2.26830559
160glandular epithelial cell differentiation (GO:0002067)2.25445102
161trabecula formation (GO:0060343)2.25176095
162positive regulation of metanephros development (GO:0072216)2.25067655
163mesenchyme morphogenesis (GO:0072132)2.24211989
164regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23748527
165heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.22179417
166fibril organization (GO:0097435)2.20881635
167protein maturation by protein folding (GO:0022417)2.20025015
168regulation of establishment of planar polarity (GO:0090175)2.19999423
169negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.19862984
170vascular endothelial growth factor signaling pathway (GO:0038084)2.19722204
171thyroid gland development (GO:0030878)2.19152877
172maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.19054163
173heparan sulfate proteoglycan metabolic process (GO:0030201)2.17916362
174lymphangiogenesis (GO:0001946)2.17399344
175epithelial cell differentiation involved in kidney development (GO:0035850)2.15595023
176negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.15261795
177cranial nerve morphogenesis (GO:0021602)2.14753508
178adhesion of symbiont to host (GO:0044406)2.11170436
179cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.11091714
180axon extension (GO:0048675)2.10731665
181regulation of mesenchymal cell apoptotic process (GO:2001053)2.10728385
182regulation of mammary gland epithelial cell proliferation (GO:0033599)2.10174906
183protein hydroxylation (GO:0018126)2.09943741
184tooth mineralization (GO:0034505)2.09018000
185embryonic skeletal system morphogenesis (GO:0048704)2.08459975
186aggressive behavior (GO:0002118)2.07057957
187positive regulation of protein depolymerization (GO:1901881)2.06830152
188chaperone-mediated protein transport (GO:0072321)2.06119682
189synaptic vesicle docking involved in exocytosis (GO:0016081)2.05600336
190positive regulation of glomerulus development (GO:0090193)2.05521953
191ventricular septum morphogenesis (GO:0060412)2.05111110
192regulation of p38MAPK cascade (GO:1900744)2.04190430
193negative regulation of embryonic development (GO:0045992)2.03718909
194negative regulation of catenin import into nucleus (GO:0035414)2.03113047
195microtubule severing (GO:0051013)2.01671841
196non-canonical Wnt signaling pathway (GO:0035567)2.01445309
197uterus development (GO:0060065)2.00801454
198postsynaptic membrane organization (GO:0001941)2.00529050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.19261758
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.11707272
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.78474042
4SCL_19346495_ChIP-Seq_HPC-7_Human3.73335605
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.61042215
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48993967
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.45806017
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39306146
9EED_16625203_ChIP-ChIP_MESCs_Mouse3.32520409
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.13716124
11PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.04702851
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.96973109
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.96973109
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96563973
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93108624
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.88226268
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80093928
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.78777155
19E2F7_22180533_ChIP-Seq_HELA_Human2.75953549
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74454510
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72853934
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69517131
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65346218
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64685241
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.63014618
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60609665
27TP53_20018659_ChIP-ChIP_R1E_Mouse2.55569788
28* VDR_21846776_ChIP-Seq_THP-1_Human2.55247853
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.50833710
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50655493
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.49684642
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.47749804
33ZNF263_19887448_ChIP-Seq_K562_Human2.39905930
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39163040
35* CBX2_27304074_Chip-Seq_ESCs_Mouse2.38272527
36RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31753102
37BRD4_27068464_Chip-Seq_AML-cells_Mouse2.30597374
38* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29985259
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29723247
40ESR2_21235772_ChIP-Seq_MCF-7_Human2.28979069
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26971114
42MYC_22102868_ChIP-Seq_BL_Human2.21926109
43ERG_21242973_ChIP-ChIP_JURKAT_Human2.21487186
44SPI1_23547873_ChIP-Seq_NB4_Human2.20336728
45GATA1_22383799_ChIP-Seq_G1ME_Mouse2.19182576
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17338576
47EZH2_27294783_Chip-Seq_ESCs_Mouse2.16820921
48* VDR_24763502_ChIP-Seq_THP-1_Human2.12223633
49RUNX1_22412390_ChIP-Seq_EML_Mouse2.08580651
50RNF2_27304074_Chip-Seq_ESCs_Mouse2.07357153
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06888786
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06628641
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04315565
54EGR1_19374776_ChIP-ChIP_THP-1_Human2.03681386
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01387366
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.00699052
57STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00056711
58TCF7_22412390_ChIP-Seq_EML_Mouse1.98284391
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96856335
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94284115
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93593910
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88522680
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88282884
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86507627
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79911911
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.78578017
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78033385
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.76134749
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75157930
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75116702
71RACK7_27058665_Chip-Seq_MCF-7_Human1.74413125
72MAF_26560356_Chip-Seq_TH1_Human1.72564179
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71772780
74MYB_26560356_Chip-Seq_TH2_Human1.69033021
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67979368
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67022239
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.66430975
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.66153040
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.65827044
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.64093601
81KDM2B_26808549_Chip-Seq_K562_Human1.59900330
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57318842
83* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53036862
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52726069
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52466800
86UTX_26944678_Chip-Seq_JUKART_Human1.51356561
87* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51321001
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51180720
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.50658399
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50545973
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50521455
92* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50200656
93CTCF_27219007_Chip-Seq_Bcells_Human1.50139322
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50077345
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.50002217
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46927997
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43830643
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43215764
99* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41218059
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39980445
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39506485
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39270451
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35145234
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33567224
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32463761
106MYB_26560356_Chip-Seq_TH1_Human1.29737760
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29077560
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.28309551
109CLOCK_20551151_ChIP-Seq_293T_Human1.27959585
110LXR_22292898_ChIP-Seq_THP-1_Human1.27898502
111SA1_22415368_ChIP-Seq_MEFs_Mouse1.27414731
112GATA1_22025678_ChIP-Seq_K562_Human1.27404662
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26357881
114TET1_21490601_ChIP-Seq_MESCs_Mouse1.23857479
115PU_27001747_Chip-Seq_BMDM_Mouse1.22669022
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20834304
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20520207
118SMC3_22415368_ChIP-Seq_MEFs_Mouse1.19683550
119* ELK3_25401928_ChIP-Seq_HUVEC_Human1.19442724
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19210558
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19047491
122* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17988368
123SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17365157
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17341524
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16999315
126* RNF2_27304074_Chip-Seq_NSC_Mouse1.16921572
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16362818
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15842563
129XRN2_22483619_ChIP-Seq_HELA_Human1.14356217
130TP53_22127205_ChIP-Seq_IMR90_Human1.14068746
131SPI1_23127762_ChIP-Seq_K562_Human1.14041922
132MAF_26560356_Chip-Seq_TH2_Human1.14040506
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12683647
134VDR_23849224_ChIP-Seq_CD4+_Human1.12664801
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12659993
136KDM2B_26808549_Chip-Seq_DND41_Human1.11878586
137GATA1_19941826_ChIP-Seq_K562_Human1.11476752
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10326954
139KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10134259
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08962750
141* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08348107
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07771883
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07597882
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07269340
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06859075
146EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06730154
147TFEB_21752829_ChIP-Seq_HELA_Human1.06467065
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06409412
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06390777
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05802657
151CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05760962
152MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04811781
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03701323
154DCP1A_22483619_ChIP-Seq_HELA_Human1.03111952
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03106321
156MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01639519
157ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00546003
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99687410
159SA1_27219007_Chip-Seq_ERYTHROID_Human0.99315322
160P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98720124
161* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98472475
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97453212
163KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95083648
164* E2F1_21310950_ChIP-Seq_MCF-7_Human0.94975901
165TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94769964
166ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94176605
167EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93924302
168KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93809848
169GATA2_19941826_ChIP-Seq_K562_Human0.93202623
170PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92976765
171MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92526502
172BCL6_27268052_Chip-Seq_Bcells_Human0.92135902
173SOX3_22085726_ChIP-Seq_NPCs_Mouse0.91770590
174NCOR1_26117541_ChIP-Seq_K562_Human0.91742800
175ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91732666
176EP300_21415370_ChIP-Seq_HL-1_Mouse0.91501807
177* CREB1_26743006_Chip-Seq_LNCaP_Human0.91392161
178GATA3_27048872_Chip-Seq_THYMUS_Human0.91143679
179CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90605669
180SMC4_20622854_ChIP-Seq_HELA_Human0.90191239
181ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90146292
182P68_20966046_ChIP-Seq_HELA_Human0.87969431
183DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87742566
184SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87269740
185* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86506136
186* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86459902
187SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86318590
188KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84606514
189NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84101326
190CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82491377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.99219425
2MP0003436_decreased_susceptibility_to3.33264348
3MP0001835_abnormal_antigen_presentation3.14153063
4MP0005623_abnormal_meninges_morphology3.03814232
5MP0005464_abnormal_platelet_physiology3.02963393
6MP0003303_peritoneal_inflammation3.01742923
7MP0008438_abnormal_cutaneous_collagen2.98391225
8MP0009785_altered_susceptibility_to2.91972583
9MP0003656_abnormal_erythrocyte_physiolo2.75094870
10MP0002419_abnormal_innate_immunity2.63624911
11MP0005025_abnormal_response_to2.56037549
12MP0005397_hematopoietic_system_phenotyp2.52823527
13MP0001545_abnormal_hematopoietic_system2.52823527
14MP0005174_abnormal_tail_pigmentation2.46597610
15MP0004510_myositis2.44697586
16MP0005000_abnormal_immune_tolerance2.41823158
17MP0003705_abnormal_hypodermis_morpholog2.37861152
18MP0005058_abnormal_lysosome_morphology2.35495096
19MP0003724_increased_susceptibility_to2.35257475
20MP0004147_increased_porphyrin_level2.35215551
21MP0009278_abnormal_bone_marrow2.30003928
22MP0000537_abnormal_urethra_morphology2.25814028
23MP0000685_abnormal_immune_system2.21874460
24MP0000013_abnormal_adipose_tissue2.20689572
25MP0003283_abnormal_digestive_organ2.18201240
26MP0002452_abnormal_antigen_presenting2.15255146
27MP0005275_abnormal_skin_tensile2.14846352
28MP0000049_abnormal_middle_ear2.12822612
29MP0010368_abnormal_lymphatic_system2.12483930
30MP0002148_abnormal_hypersensitivity_rea2.11856172
31MP0003172_abnormal_lysosome_physiology2.10089783
32MP0009250_abnormal_appendicular_skeleto2.07720703
33MP0002234_abnormal_pharynx_morphology2.06427978
34MP0005503_abnormal_tendon_morphology2.06078623
35MP0004808_abnormal_hematopoietic_stem2.05105812
36MP0001188_hyperpigmentation2.01368508
37MP0004858_abnormal_nervous_system2.00449741
38MP0002420_abnormal_adaptive_immunity1.99289716
39MP0005257_abnormal_intraocular_pressure1.99230005
40MP0001819_abnormal_immune_cell1.98024358
41MP0002723_abnormal_immune_serum1.97536189
42MP0009053_abnormal_anal_canal1.95696334
43MP0002396_abnormal_hematopoietic_system1.93162167
44MP0002398_abnormal_bone_marrow1.93019606
45MP0000678_abnormal_parathyroid_gland1.85423943
46MP0000490_abnormal_crypts_of1.84883269
47MP0000343_altered_response_to1.82007919
48MP0000465_gastrointestinal_hemorrhage1.81875656
49MP0004272_abnormal_basement_membrane1.80800957
50MP0001800_abnormal_humoral_immune1.79502078
51MP0009780_abnormal_chondrocyte_physiolo1.78067325
52MP0005671_abnormal_response_to1.77897651
53MP0005367_renal/urinary_system_phenotyp1.76601846
54MP0000516_abnormal_urinary_system1.76601846
55MP0002249_abnormal_larynx_morphology1.74760261
56MP0009333_abnormal_splenocyte_physiolog1.72691399
57MP0002405_respiratory_system_inflammati1.70649160
58MP0000681_abnormal_thyroid_gland1.69752473
59MP0001542_abnormal_bone_strength1.68453677
60MP0000762_abnormal_tongue_morphology1.68263285
61MP0000716_abnormal_immune_system1.65080836
62MP0006082_CNS_inflammation1.64537211
63MP0000534_abnormal_ureter_morphology1.63243744
64MP0004859_abnormal_synaptic_plasticity1.61741636
65MP0000462_abnormal_digestive_system1.60692637
66MP0001790_abnormal_immune_system1.59375048
67MP0005387_immune_system_phenotype1.59375048
68MP0002796_impaired_skin_barrier1.59319739
69MP0000566_synostosis1.57060734
70MP0001533_abnormal_skeleton_physiology1.56870980
71MP0008469_abnormal_protein_level1.56836027
72MP0005084_abnormal_gallbladder_morpholo1.56662836
73MP0002429_abnormal_blood_cell1.55987255
74MP0001845_abnormal_inflammatory_respons1.55496654
75MP0005646_abnormal_pituitary_gland1.55148428
76MP0010030_abnormal_orbit_morphology1.54758082
77MP0000689_abnormal_spleen_morphology1.52983066
78MP0005501_abnormal_skin_physiology1.50907242
79MP0003075_altered_response_to1.50345194
80MP0003186_abnormal_redox_activity1.49914179
81MP0002722_abnormal_immune_system1.48997682
82MP0000751_myopathy1.48413085
83MP0001853_heart_inflammation1.46712027
84MP0000579_abnormal_nail_morphology1.45394262
85MP0006054_spinal_hemorrhage1.41609035
86MP0010155_abnormal_intestine_physiology1.41302840
87MP0005409_darkened_coat_color1.40885419
88MP0003183_abnormal_peptide_metabolism1.40074534
89MP0000858_altered_metastatic_potential1.39879451
90MP0009764_decreased_sensitivity_to1.39284385
91MP0003942_abnormal_urinary_system1.35292926
92MP0005508_abnormal_skeleton_morphology1.33814267
93MP0005595_abnormal_vascular_smooth1.30112339
94MP0003448_altered_tumor_morphology1.27456564
95MP0003300_gastrointestinal_ulcer1.26870764
96MP0005083_abnormal_biliary_tract1.26098946
97MP0001346_abnormal_lacrimal_gland1.24461187
98MP0000003_abnormal_adipose_tissue1.23999690
99MP0010771_integument_phenotype1.23120345
100MP0009379_abnormal_foot_pigmentation1.22516179
101MP0009384_cardiac_valve_regurgitation1.21790569
102MP0000750_abnormal_muscle_regeneration1.20880762
103MP0005166_decreased_susceptibility_to1.19001403
104MP0010234_abnormal_vibrissa_follicle1.18618232
105MP0003329_amyloid_beta_deposits1.15689358
106MP0003191_abnormal_cellular_cholesterol1.15489135
107MP0009840_abnormal_foam_cell1.15211875
108MP0001958_emphysema1.14886661
109MP0002932_abnormal_joint_morphology1.14828592
110MP0002060_abnormal_skin_morphology1.13258695
111MP0000778_abnormal_nervous_system1.12351203
112MP0002736_abnormal_nociception_after1.11052651
113MP0010352_gastrointestinal_tract_polyps1.10813488
114MP0002177_abnormal_outer_ear1.10116194
115MP0005410_abnormal_fertilization1.04514510
116MP0000383_abnormal_hair_follicle1.04228416
117MP0003385_abnormal_body_wall1.02854324
118MP0002735_abnormal_chemical_nociception1.02658935
119MP0000467_abnormal_esophagus_morphology1.01555409
120MP0004947_skin_inflammation0.99252820
121MP0002998_abnormal_bone_remodeling0.98845870
122MP0003634_abnormal_glial_cell0.97209370
123MP0001881_abnormal_mammary_gland0.96644138
124MP0000767_abnormal_smooth_muscle0.96141595
125MP0010678_abnormal_skin_adnexa0.95979267
126MP0009763_increased_sensitivity_to0.95137415
127MP0002166_altered_tumor_susceptibility0.94984234
128MP0006036_abnormal_mitochondrial_physio0.94737308
129MP0002909_abnormal_adrenal_gland0.92634360
130MP0000733_abnormal_muscle_development0.91243055
131MP0002282_abnormal_trachea_morphology0.91081175
132MP0000703_abnormal_thymus_morphology0.90918129
133MP0002095_abnormal_skin_pigmentation0.90721856
134MP0005670_abnormal_white_adipose0.90155454
135MP0003866_abnormal_defecation0.90096262
136MP0005076_abnormal_cell_differentiation0.89151437
137MP0004885_abnormal_endolymph0.89094742
138MP0004270_analgesia0.88052049
139MP0002006_tumorigenesis0.88027266
140MP0005375_adipose_tissue_phenotype0.87904305
141MP0002693_abnormal_pancreas_physiology0.87249297
142MP0003828_pulmonary_edema0.87134291
143MP0004185_abnormal_adipocyte_glucose0.86794971
144MP0005197_abnormal_uvea_morphology0.86324168
145MP0003315_abnormal_perineum_morphology0.85322144
146MP0002098_abnormal_vibrissa_morphology0.83914171
147MP0002295_abnormal_pulmonary_circulatio0.83506061
148MP0005319_abnormal_enzyme/_coenzyme0.82894455
149MP0002896_abnormal_bone_mineralization0.82021086
150MP0000015_abnormal_ear_pigmentation0.81781750
151MP0003123_paternal_imprinting0.81646390
152MP0001440_abnormal_grooming_behavior0.81553029
153MP0002160_abnormal_reproductive_system0.81504418
154MP0001968_abnormal_touch/_nociception0.80819606
155MP0002019_abnormal_tumor_incidence0.80752463
156MP0000598_abnormal_liver_morphology0.78682469
157MP0001299_abnormal_eye_distance/0.78649011
158MP0001348_abnormal_lacrimal_gland0.78099071
159MP0002116_abnormal_craniofacial_bone0.77944969
160MP0000371_diluted_coat_color0.77864219
161MP0001851_eye_inflammation0.77554096
162MP0003453_abnormal_keratinocyte_physiol0.77499815
163MP0008775_abnormal_heart_ventricle0.77093741
164MP0001502_abnormal_circadian_rhythm0.76086937
165MP0000569_abnormal_digit_pigmentation0.75847167
166MP0001663_abnormal_digestive_system0.75738290
167MP0001879_abnormal_lymphatic_vessel0.75019235
168MP0005310_abnormal_salivary_gland0.74554654
169MP0009115_abnormal_fat_cell0.74381866
170MP0002114_abnormal_axial_skeleton0.73841732
171MP0005408_hypopigmentation0.72880181
172MP0004130_abnormal_muscle_cell0.72037041
173MP0003137_abnormal_impulse_conducting0.71976905
174MP0001905_abnormal_dopamine_level0.71226860
175MP0005390_skeleton_phenotype0.70865424
176MP0003795_abnormal_bone_structure0.70384308
177MP0002233_abnormal_nose_morphology0.70044530
178MP0005334_abnormal_fat_pad0.68553847
179MP0005636_abnormal_mineral_homeostasis0.68407076
180MP0005164_abnormal_response_to0.68247580
181MP0002108_abnormal_muscle_morphology0.68073770
182MP0003755_abnormal_palate_morphology0.67742455
183MP0000749_muscle_degeneration0.67468112
184MP0000428_abnormal_craniofacial_morphol0.67156514
185MP0003279_aneurysm0.67140543
186MP0000313_abnormal_cell_death0.66737253
187MP0003943_abnormal_hepatobiliary_system0.66503221
188MP0005167_abnormal_blood-brain_barrier0.66472925
189MP0000163_abnormal_cartilage_morphology0.64514647
190MP0005666_abnormal_adipose_tissue0.64028217
191MP0002127_abnormal_cardiovascular_syste0.63987164
192MP0004087_abnormal_muscle_fiber0.63932257

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.74608791
2Petechiae (HP:0000967)4.53328272
3Recurrent abscess formation (HP:0002722)4.46865013
4Eczematoid dermatitis (HP:0000976)4.28825849
5Recurrent gram-negative bacterial infections (HP:0005420)4.20049927
6Recurrent bacterial skin infections (HP:0005406)4.11759036
7Atrophic scars (HP:0001075)4.01405820
8Abnormality of cells of the erythroid lineage (HP:0012130)3.99803698
9Abnormal number of erythroid precursors (HP:0012131)3.88897541
10Prolonged bleeding time (HP:0003010)3.87888373
11Premature rupture of membranes (HP:0001788)3.83567203
12Elevated erythrocyte sedimentation rate (HP:0003565)3.73083854
13Thrombocytosis (HP:0001894)3.70482115
14Increased cerebral lipofuscin (HP:0011813)3.61192960
15Abnormality of macrophages (HP:0004311)3.56272818
16Abnormal platelet function (HP:0011869)3.51546622
17Impaired platelet aggregation (HP:0003540)3.51546622
18Myositis (HP:0100614)3.48261439
19Menorrhagia (HP:0000132)3.44745638
20Protrusio acetabuli (HP:0003179)3.35345148
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.33697242
22Short middle phalanx of the 5th finger (HP:0004220)3.31038667
23Dysostosis multiplex (HP:0000943)3.30744992
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.13780083
25Mediastinal lymphadenopathy (HP:0100721)3.06999354
26Cellulitis (HP:0100658)3.06863997
27Vacuolated lymphocytes (HP:0001922)3.04246201
28Morphological abnormality of the middle ear (HP:0008609)3.03688683
29Interstitial pulmonary disease (HP:0006530)3.02168443
30Epistaxis (HP:0000421)2.99518671
31Pallor (HP:0000980)2.93832784
32Orchitis (HP:0100796)2.92924790
33Hypercortisolism (HP:0001578)2.91684199
34Double outlet right ventricle (HP:0001719)2.87903475
35Congenital malformation of the right heart (HP:0011723)2.87903475
36Nasal polyposis (HP:0100582)2.85855731
37Fragile skin (HP:0001030)2.85508459
38Aplastic anemia (HP:0001915)2.83412924
39Hyperparathyroidism (HP:0000843)2.76324564
40Genu recurvatum (HP:0002816)2.75693850
41Poor head control (HP:0002421)2.75687367
42Purpura (HP:0000979)2.74962947
43Urinary glycosaminoglycan excretion (HP:0003541)2.74454126
44Mucopolysacchariduria (HP:0008155)2.74454126
45Abnormality of T cell physiology (HP:0011840)2.72031676
46Recurrent skin infections (HP:0001581)2.68301385
47Urticaria (HP:0001025)2.66126511
48Fatigue (HP:0012378)2.65483850
49Ankle contracture (HP:0006466)2.65296843
50Abnormality of the nasal mucosa (HP:0000433)2.61975756
51Meningitis (HP:0001287)2.58063052
52Obstructive lung disease (HP:0006536)2.57645099
53Chronic obstructive pulmonary disease (HP:0006510)2.57645099
54Gingival bleeding (HP:0000225)2.57437502
55Progressive neurologic deterioration (HP:0002344)2.56567840
56Recurrent fungal infections (HP:0002841)2.55894761
57Abnormality of glycolipid metabolism (HP:0010969)2.54485913
58Abnormality of liposaccharide metabolism (HP:0010968)2.54485913
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.54485913
60Abnormal platelet volume (HP:0011876)2.50825486
61Hallux valgus (HP:0001822)2.50275833
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45880393
63Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.45203624
64Increased serum ferritin (HP:0003281)2.44267463
65Abnormality of polysaccharide metabolism (HP:0011012)2.43924804
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43924804
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43924804
68Recurrent viral infections (HP:0004429)2.42293241
69Deviation of the hallux (HP:0010051)2.42212044
70Peritonitis (HP:0002586)2.41057832
71Pulmonary infiltrates (HP:0002113)2.39743441
72Reticulocytopenia (HP:0001896)2.34659782
73Hypoplastic left heart (HP:0004383)2.33606638
74Abnormal umbilical cord blood vessels (HP:0011403)2.32774255
75Single umbilical artery (HP:0001195)2.32774255
76Abnormality of the fetal cardiovascular system (HP:0010948)2.32774255
77Increased mean platelet volume (HP:0011877)2.32659407
78Gingivitis (HP:0000230)2.32632409
79Autoimmune thrombocytopenia (HP:0001973)2.32350177
80Neonatal short-limb short stature (HP:0008921)2.31049573
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.30947310
82Papilledema (HP:0001085)2.29379718
83Hydroureter (HP:0000072)2.28898446
84Neurofibrillary tangles (HP:0002185)2.28631792
85Abnormality of the umbilical cord (HP:0010881)2.28053011
86Disinhibition (HP:0000734)2.28016412
87Periodontitis (HP:0000704)2.26492293
88Ulnar bowing (HP:0003031)2.25932289
89Albinism (HP:0001022)2.25927484
90Broad distal phalanx of finger (HP:0009836)2.25502856
91Axonal loss (HP:0003447)2.21747535
92Nausea (HP:0002018)2.20847846
93Aplasia involving bones of the upper limbs (HP:0009823)2.20158204
94Aplasia of the phalanges of the hand (HP:0009802)2.20158204
95Aplasia involving bones of the extremities (HP:0009825)2.20158204
96Concave nail (HP:0001598)2.19925416
97Abnormality of reticulocytes (HP:0004312)2.19776244
98Abnormality of the distal phalanges of the toes (HP:0010182)2.19320959
99Tetraparesis (HP:0002273)2.18586482
100Vertebral compression fractures (HP:0002953)2.18108333
101Neoplasm of head and neck (HP:0012288)2.16802025
102Esophageal neoplasm (HP:0100751)2.16802025
103Exertional dyspnea (HP:0002875)2.16795491
104Shallow orbits (HP:0000586)2.14868841
105Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.13815181
106Macrocytic anemia (HP:0001972)2.13084065
107Cerebral inclusion bodies (HP:0100314)2.11857821
108Reticulocytosis (HP:0001923)2.11404254
109IgM deficiency (HP:0002850)2.10924075
110Short clavicles (HP:0000894)2.10836131
111Hyperthyroidism (HP:0000836)2.10179840
112Elbow flexion contracture (HP:0002987)2.09654909
113Poikilocytosis (HP:0004447)2.09448289
114Soft skin (HP:0000977)2.09194736
115Selective tooth agenesis (HP:0001592)2.08179211
116Coronal craniosynostosis (HP:0004440)2.07317142
117Basal ganglia calcification (HP:0002135)2.06793778
118Abnormality of dentin (HP:0010299)2.06220775
119Type 1 muscle fiber predominance (HP:0003803)2.05674009
120Infantile muscular hypotonia (HP:0008947)2.05232019
121Abnormality of the phalanges of the 5th finger (HP:0004213)2.05061239
122Mildly elevated creatine phosphokinase (HP:0008180)2.05005720
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04621696
124Wormian bones (HP:0002645)2.04189724
125Polycythemia (HP:0001901)2.04173097
126Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03936858
127Short nail (HP:0001799)2.03489931
128Atrioventricular block (HP:0001678)2.03412007
129Slender long bone (HP:0003100)2.03404367
130Hyporeflexia of lower limbs (HP:0002600)2.03088385
131Abnormality of iron homeostasis (HP:0011031)2.01704507
132Vasculitis (HP:0002633)2.00960243
133Hypoplasia of the iris (HP:0007676)2.00876570
134Pili torti (HP:0003777)2.00058099
135Aplasia/Hypoplasia of the clavicles (HP:0006710)1.98436617
136Reduced antithrombin III activity (HP:0001976)1.95373208
137Bone cyst (HP:0012062)1.93711851
138Gastrointestinal stroma tumor (HP:0100723)1.93665956
139Bulbar palsy (HP:0001283)1.91850543
140Hypoplastic heart (HP:0001961)1.91619824
141Microcytic anemia (HP:0001935)1.90072692
142Down-sloping shoulders (HP:0200021)1.89560267
143Bladder diverticulum (HP:0000015)1.88842909
144Ragged-red muscle fibers (HP:0003200)1.88384725
145Absent phalangeal crease (HP:0006109)1.88139622
146Unilateral renal agenesis (HP:0000122)1.87692973
147Chronic mucocutaneous candidiasis (HP:0002728)1.87545602
148Recurrent cutaneous fungal infections (HP:0011370)1.87545602
149Stridor (HP:0010307)1.87154739
150Optic neuritis (HP:0100653)1.86275862
151Retrobulbar optic neuritis (HP:0100654)1.86275862
152Chronic otitis media (HP:0000389)1.86075882
153Spinal rigidity (HP:0003306)1.85049389
154Pathologic fracture (HP:0002756)1.83607060
155Loss of speech (HP:0002371)1.82783536
156Abnormal atrioventricular conduction (HP:0005150)1.82597708
157Episodic fever (HP:0001954)1.82379584
158Multiple enchondromatosis (HP:0005701)1.81739447
159J-shaped sella turcica (HP:0002680)1.81255499
160Thoracic kyphosis (HP:0002942)1.81022522
161Abnormality of T cells (HP:0002843)1.80650192
162Nuclear cataract (HP:0100018)1.79926033
163Asymmetric septal hypertrophy (HP:0001670)1.79747336
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78583433
165Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78583433
166Recurrent bronchitis (HP:0002837)1.77752077
167Growth hormone excess (HP:0000845)1.77341041
168Pulmonary artery stenosis (HP:0004415)1.76886699
169Failure to thrive in infancy (HP:0001531)1.75656106
170Hypotrichosis (HP:0001006)1.75612485
171Multiple lipomas (HP:0001012)1.74262159
172Abnormality of the middle phalanges of the toes (HP:0010183)1.73094480
173Hyperextensible skin (HP:0000974)1.72952685
174Transposition of the great arteries (HP:0001669)1.71594358
175Abnormal connection of the cardiac segments (HP:0011545)1.71594358
176Abnormal ventriculo-arterial connection (HP:0011563)1.71594358
177Venous abnormality (HP:0002624)1.71273077
178Muscle fiber splitting (HP:0003555)1.70534183
179Abnormality of the phalanges of the hallux (HP:0010057)1.70307993
180Abnormal finger flexion creases (HP:0006143)1.70249734
181Turricephaly (HP:0000262)1.69486992
182Congenital glaucoma (HP:0001087)1.66519290
183Knee flexion contracture (HP:0006380)1.65653802
184Abnormality of the lower motor neuron (HP:0002366)1.65124435
185Delayed gross motor development (HP:0002194)1.64775840
186Long toe (HP:0010511)1.64738643
187Increased variability in muscle fiber diameter (HP:0003557)1.64038059
188Nonimmune hydrops fetalis (HP:0001790)1.63644151
189Abnormality of the parathyroid morphology (HP:0011766)1.63172840
190Natal tooth (HP:0000695)1.63136129
191Cubitus valgus (HP:0002967)1.62209551
192Joint stiffness (HP:0001387)1.61756888
193Venous insufficiency (HP:0005293)1.61691462
194Maternal diabetes (HP:0009800)1.61036708
195Limb dystonia (HP:0002451)1.59187949
196Heart block (HP:0012722)1.58950515
197Mitral regurgitation (HP:0001653)1.55777016
198Adrenal overactivity (HP:0002717)1.55079992
199Insulin-resistant diabetes mellitus (HP:0000831)1.54793384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.57725882
2ERN13.65038268
3PIM22.85246297
4RIPK42.69019316
5EEF2K2.68835260
6KIT2.66859847
7EPHB22.60945387
8MUSK2.55238712
9TBK12.49326710
10MAP4K12.30362489
11TESK12.17947211
12TAOK32.05872202
13TRIB32.01833234
14IKBKE1.98012650
15PRKD31.94103595
16TYK21.92987002
17PNCK1.92169318
18DDR21.91792114
19ACVR1B1.87865400
20SCYL21.86712261
21LIMK11.86286998
22LATS21.79532385
23RPS6KA41.76806709
24IRAK41.73008376
25IRAK31.70473452
26PKN21.68632608
27NTRK11.66653214
28BTK1.64739713
29DYRK31.64503259
30TEC1.64370292
31EPHA21.59594866
32MARK11.56941740
33CASK1.55874337
34PIM11.54247630
35TAOK11.50950296
36PHKG21.50078166
37PHKG11.50078166
38DMPK1.47542543
39ABL21.43084849
40GRK11.42479783
41TGFBR11.37581741
42RIPK11.36347684
43LRRK21.35130581
44BLK1.34059139
45IKBKB1.33866299
46SYK1.33788131
47PTK21.33542910
48TAOK21.30561654
49MAP3K91.27488957
50MAP3K101.26696836
51BMX1.24481387
52TTN1.21856298
53MAPK71.19097720
54JAK31.19047432
55LMTK21.15031762
56PDGFRA1.12472490
57ZAP701.11329848
58CSF1R1.10047740
59MYLK1.09710845
60MAPKAPK31.07947966
61TESK21.06413556
62SIK11.02839361
63MAP3K61.00447870
64MAPK121.00031141
65STK240.99624879
66PAK20.98957847
67PBK0.98747832
68NEK20.98054531
69CDK190.97784285
70FLT30.96448447
71STK100.95646090
72MAP2K20.95354582
73MAP3K110.95237564
74MATK0.94315233
75STK160.93365597
76CAMK2B0.92626670
77JAK20.91747817
78MAP3K140.90103211
79BMPR1B0.90020023
80GRK60.89439700
81DYRK1B0.87932499
82CAMK2G0.87838110
83PAK60.87282416
84CLK10.86867001
85DAPK10.86842288
86ROCK20.86499299
87MAP2K40.85843703
88LYN0.82662190
89TGFBR20.82278807
90AURKA0.81755761
91HIPK20.80927751
92MAP2K10.80709976
93PRKD20.78934243
94PTK60.78730399
95AKT20.77490855
96PDK20.77104880
97RPS6KC10.75660000
98RPS6KL10.75660000
99BRAF0.74409856
100JAK10.73832343
101CAMK2D0.73573788
102DAPK30.73139815
103CDK40.72191442
104MAPK150.71813231
105MAP3K120.71469981
106RAF10.71223996
107ARAF0.70452846
108MET0.70091486
109HCK0.70069728
110CDK60.69227053
111MAP3K50.68357430
112MAPK110.68020007
113VRK10.66868922
114PRKG20.66709538
115MINK10.66546571
116PRKCG0.66369016
117PDK10.66304763
118MOS0.65684077
119CSNK1G20.65048380
120RPS6KB20.64951177
121CHUK0.64160769
122LCK0.62834081
123DAPK20.60709849
124EPHA40.60515654
125MAP3K30.60134975
126MAPKAPK20.60091357
127MAP3K10.59534353
128FES0.58395949
129GSK3A0.57605334
130TIE10.56611950
131SIK20.55908760
132KDR0.54537407
133PLK20.54122849
134SRPK10.52914385
135MARK30.52278470
136MST1R0.52122492
137MAPKAPK50.51774310
138TLK10.51664961
139VRK20.51445311
140MAP2K30.51062251
141IRAK20.50669476
142CDK90.50581569
143CSNK1G30.50512019
144ADRBK10.50054554
145MTOR0.49264630
146WEE10.49234814
147PDPK10.48520785
148CDC70.47687411
149RPS6KA20.45707519
150PRKD10.45323025
151UHMK10.44225057
152MAP2K60.44157240
153NEK90.43892757
154CAMK2A0.42619886
155CSK0.42261568
156CDK11A0.42135219
157RPS6KA10.41942547
158PRKCE0.41578207
159TXK0.41214564
160EGFR0.40695110
161RPS6KA60.40432287
162PAK40.39107374
163BCKDK0.37796589
164ILK0.36766090
165TRPM70.34791591
166STK40.34199864
167PRKCD0.29642980
168PDK30.27432628

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.56125797
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.48685515
3Leishmaniasis_Homo sapiens_hsa051402.74808560
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.36093709
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25181072
6Osteoclast differentiation_Homo sapiens_hsa043802.24036223
7Fatty acid elongation_Homo sapiens_hsa000622.15740645
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10183744
9Legionellosis_Homo sapiens_hsa051342.01004834
10Vitamin B6 metabolism_Homo sapiens_hsa007501.98122673
11Tuberculosis_Homo sapiens_hsa051521.96042505
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.92896163
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.91887825
14DNA replication_Homo sapiens_hsa030301.84433347
15ECM-receptor interaction_Homo sapiens_hsa045121.81218959
16Acute myeloid leukemia_Homo sapiens_hsa052211.80752532
17B cell receptor signaling pathway_Homo sapiens_hsa046621.75602149
18Hepatitis B_Homo sapiens_hsa051611.74074559
19Lysosome_Homo sapiens_hsa041421.70892246
20Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.62936054
21Pertussis_Homo sapiens_hsa051331.58980798
22Apoptosis_Homo sapiens_hsa042101.56920552
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55685273
24Folate biosynthesis_Homo sapiens_hsa007901.55155907
25Measles_Homo sapiens_hsa051621.54462466
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53810505
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53302341
28Shigellosis_Homo sapiens_hsa051311.52619984
29Hematopoietic cell lineage_Homo sapiens_hsa046401.52609662
30Prion diseases_Homo sapiens_hsa050201.51453539
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48978395
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46898996
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44908449
34Herpes simplex infection_Homo sapiens_hsa051681.43081244
35TNF signaling pathway_Homo sapiens_hsa046681.42731302
36Sulfur relay system_Homo sapiens_hsa041221.39882600
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37981337
38Malaria_Homo sapiens_hsa051441.37903970
39Cocaine addiction_Homo sapiens_hsa050301.37494475
40Antigen processing and presentation_Homo sapiens_hsa046121.36974677
41Salmonella infection_Homo sapiens_hsa051321.34396945
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.34134242
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33901531
44Influenza A_Homo sapiens_hsa051641.33552417
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33213391
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32241778
47Synaptic vesicle cycle_Homo sapiens_hsa047211.31843263
48Phagosome_Homo sapiens_hsa041451.31180590
49Staphylococcus aureus infection_Homo sapiens_hsa051501.30258989
50Circadian entrainment_Homo sapiens_hsa047131.26865662
51Renin secretion_Homo sapiens_hsa049241.26125617
52Gap junction_Homo sapiens_hsa045401.23974822
53Toxoplasmosis_Homo sapiens_hsa051451.23284806
54Dilated cardiomyopathy_Homo sapiens_hsa054141.20938491
55Cardiac muscle contraction_Homo sapiens_hsa042601.20527474
56Sphingolipid metabolism_Homo sapiens_hsa006001.19856145
57Chronic myeloid leukemia_Homo sapiens_hsa052201.18528274
58Protein digestion and absorption_Homo sapiens_hsa049741.18171747
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.17895374
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13462370
61Platelet activation_Homo sapiens_hsa046111.13386825
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13228662
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11728762
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10529648
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10213995
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08564758
67Rheumatoid arthritis_Homo sapiens_hsa053231.08527877
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08436705
69Sulfur metabolism_Homo sapiens_hsa009201.08376962
70Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06257265
71Systemic lupus erythematosus_Homo sapiens_hsa053221.05263021
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04031319
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02555028
74Protein export_Homo sapiens_hsa030601.00815823
75Focal adhesion_Homo sapiens_hsa045100.99001581
76Dorso-ventral axis formation_Homo sapiens_hsa043200.98457804
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96808612
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.96547811
79Basal cell carcinoma_Homo sapiens_hsa052170.95487167
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94368865
81Other glycan degradation_Homo sapiens_hsa005110.92346051
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91109213
83Asthma_Homo sapiens_hsa053100.91072348
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90810570
85Hedgehog signaling pathway_Homo sapiens_hsa043400.89115106
86Arginine and proline metabolism_Homo sapiens_hsa003300.88063832
87Pentose phosphate pathway_Homo sapiens_hsa000300.87738757
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87087244
89mTOR signaling pathway_Homo sapiens_hsa041500.86739259
90Nicotine addiction_Homo sapiens_hsa050330.86695499
91Glutathione metabolism_Homo sapiens_hsa004800.85037770
92Viral carcinogenesis_Homo sapiens_hsa052030.84996486
93Oxidative phosphorylation_Homo sapiens_hsa001900.84929280
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83181288
95Alzheimers disease_Homo sapiens_hsa050100.81752279
96Selenocompound metabolism_Homo sapiens_hsa004500.81572041
97Parkinsons disease_Homo sapiens_hsa050120.80881629
98Axon guidance_Homo sapiens_hsa043600.80634457
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80161515
100N-Glycan biosynthesis_Homo sapiens_hsa005100.78598664
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78381262
102Homologous recombination_Homo sapiens_hsa034400.78092881
103Galactose metabolism_Homo sapiens_hsa000520.78023903
104Melanoma_Homo sapiens_hsa052180.77597185
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.77111990
106Type I diabetes mellitus_Homo sapiens_hsa049400.76792140
107Proteasome_Homo sapiens_hsa030500.76679889
108Vibrio cholerae infection_Homo sapiens_hsa051100.76080768
109Hepatitis C_Homo sapiens_hsa051600.74674335
110Amphetamine addiction_Homo sapiens_hsa050310.74343081
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.74207713
112Dopaminergic synapse_Homo sapiens_hsa047280.73884510
113Melanogenesis_Homo sapiens_hsa049160.73539045
114Graft-versus-host disease_Homo sapiens_hsa053320.73001343
115Long-term depression_Homo sapiens_hsa047300.72384437
116Hippo signaling pathway_Homo sapiens_hsa043900.71468011
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69968279
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69252228
119Insulin secretion_Homo sapiens_hsa049110.69220522
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69186770
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66718734
122Chemokine signaling pathway_Homo sapiens_hsa040620.66694504
123Huntingtons disease_Homo sapiens_hsa050160.66181053
124Pyrimidine metabolism_Homo sapiens_hsa002400.64655604
125Amoebiasis_Homo sapiens_hsa051460.63832409
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62957342
127Non-small cell lung cancer_Homo sapiens_hsa052230.61900722
128AMPK signaling pathway_Homo sapiens_hsa041520.61377641
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60828437
130p53 signaling pathway_Homo sapiens_hsa041150.60444644
131Thyroid cancer_Homo sapiens_hsa052160.60439870
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59757671
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.59485158
134Oxytocin signaling pathway_Homo sapiens_hsa049210.59289532
135Glutamatergic synapse_Homo sapiens_hsa047240.59285477
136Salivary secretion_Homo sapiens_hsa049700.58425830
137Small cell lung cancer_Homo sapiens_hsa052220.58092579
138Tight junction_Homo sapiens_hsa045300.56922757
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55906865
140cAMP signaling pathway_Homo sapiens_hsa040240.54147388
141Pancreatic cancer_Homo sapiens_hsa052120.53640598
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53150462
143VEGF signaling pathway_Homo sapiens_hsa043700.53002781
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52647312
145Base excision repair_Homo sapiens_hsa034100.52437007
146Viral myocarditis_Homo sapiens_hsa054160.51242749
147Mismatch repair_Homo sapiens_hsa034300.50900724
148Histidine metabolism_Homo sapiens_hsa003400.49351080
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48774901
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48527683
151Alcoholism_Homo sapiens_hsa050340.48300140
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.48298053
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48293432
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48126037
155Allograft rejection_Homo sapiens_hsa053300.47401418
156Ovarian steroidogenesis_Homo sapiens_hsa049130.47329723
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46540300
158Collecting duct acid secretion_Homo sapiens_hsa049660.45949025
159Peroxisome_Homo sapiens_hsa041460.45905394
160Bladder cancer_Homo sapiens_hsa052190.45601636
161Tyrosine metabolism_Homo sapiens_hsa003500.45600929
162Cholinergic synapse_Homo sapiens_hsa047250.45041157
163HIF-1 signaling pathway_Homo sapiens_hsa040660.44844444
164beta-Alanine metabolism_Homo sapiens_hsa004100.44224721
165Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44079737
166Leukocyte transendothelial migration_Homo sapiens_hsa046700.43856235
167TGF-beta signaling pathway_Homo sapiens_hsa043500.43774126
168Insulin signaling pathway_Homo sapiens_hsa049100.43767149
169Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43099273
170Central carbon metabolism in cancer_Homo sapiens_hsa052300.42996998
171Calcium signaling pathway_Homo sapiens_hsa040200.41925754
172Prolactin signaling pathway_Homo sapiens_hsa049170.41586403
173Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41497058
174Proteoglycans in cancer_Homo sapiens_hsa052050.40938630
175Phenylalanine metabolism_Homo sapiens_hsa003600.40732047

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »