TUSC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.16443235
2protein maturation by protein folding (GO:0022417)4.70510881
3glutamate secretion (GO:0014047)4.45428154
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.44707717
5synaptic vesicle exocytosis (GO:0016079)4.38568104
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30906699
7synaptic vesicle maturation (GO:0016188)4.30780973
8neuronal action potential propagation (GO:0019227)4.13562841
9GDP-mannose metabolic process (GO:0019673)4.02617063
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.00419527
112-deoxyribonucleotide biosynthetic process (GO:0009265)3.94388784
12deoxyribose phosphate biosynthetic process (GO:0046385)3.94388784
13regulation of synaptic vesicle exocytosis (GO:2000300)3.91632671
14lysine metabolic process (GO:0006553)3.81837317
15lysine catabolic process (GO:0006554)3.81837317
16negative regulation of microtubule polymerization (GO:0031115)3.81392288
17regulation of synaptic vesicle transport (GO:1902803)3.79779322
18mitochondrial calcium ion transport (GO:0006851)3.74222163
19metallo-sulfur cluster assembly (GO:0031163)3.70162369
20iron-sulfur cluster assembly (GO:0016226)3.70162369
21neurotransmitter secretion (GO:0007269)3.61187078
22peptidyl-arginine omega-N-methylation (GO:0035247)3.55393539
23protein insertion into membrane (GO:0051205)3.46760699
24guanosine-containing compound biosynthetic process (GO:1901070)3.44422150
25L-phenylalanine metabolic process (GO:0006558)3.43691153
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.43691153
27protein targeting to mitochondrion (GO:0006626)3.41707185
28regulation of synapse structural plasticity (GO:0051823)3.39183970
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.38610766
30succinate metabolic process (GO:0006105)3.34945020
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.31382675
32L-phenylalanine catabolic process (GO:0006559)3.31382675
33vocalization behavior (GO:0071625)3.31369875
34locomotory exploration behavior (GO:0035641)3.31167778
35establishment of protein localization to mitochondrion (GO:0072655)3.26634836
36positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.24828463
37negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.21499035
38regulation of neuronal synaptic plasticity (GO:0048168)3.19389031
39nucleotide salvage (GO:0043173)3.18404442
40NADH metabolic process (GO:0006734)3.17643317
41regulation of mitochondrial translation (GO:0070129)3.17080091
42purine nucleotide salvage (GO:0032261)3.16497016
43negative regulation of dendrite morphogenesis (GO:0050774)3.16385411
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15438182
45gamma-aminobutyric acid transport (GO:0015812)3.15091581
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13618324
47negative regulation of DNA-templated transcription, elongation (GO:0032785)3.11973063
48proline biosynthetic process (GO:0006561)3.11615513
49tricarboxylic acid cycle (GO:0006099)3.10522725
50pyrimidine nucleobase catabolic process (GO:0006208)3.08524737
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08058654
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07412587
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06893940
54aspartate family amino acid catabolic process (GO:0009068)3.06701593
55GTP biosynthetic process (GO:0006183)3.06645636
56negative regulation of necrotic cell death (GO:0060547)3.06114397
57positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05682114
58cysteine metabolic process (GO:0006534)3.05442272
59activation of protein kinase A activity (GO:0034199)3.03988240
60protein localization to mitochondrion (GO:0070585)3.03791062
61protein localization to synapse (GO:0035418)3.02735402
62histone arginine methylation (GO:0034969)3.00343605
63mitochondrial fusion (GO:0008053)2.99521442
64pyrimidine nucleoside salvage (GO:0043097)2.99517711
65pyrimidine-containing compound salvage (GO:0008655)2.99517711
66regulation of oxidative phosphorylation (GO:0002082)2.99376017
67cellular ketone body metabolic process (GO:0046950)2.98535326
68regulation of glutamate receptor signaling pathway (GO:1900449)2.96971824
69deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96750138
70oxaloacetate metabolic process (GO:0006107)2.95410219
71proline transport (GO:0015824)2.95355565
72protein retention in ER lumen (GO:0006621)2.88971482
732-oxoglutarate metabolic process (GO:0006103)2.88138335
74neuromuscular process controlling posture (GO:0050884)2.88108667
75exploration behavior (GO:0035640)2.87471736
76purine deoxyribonucleotide catabolic process (GO:0009155)2.86722655
77chaperone-mediated protein transport (GO:0072321)2.86432859
78positive regulation of mitochondrion organization (GO:0010822)2.86415464
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85760181
80UTP biosynthetic process (GO:0006228)2.85587293
81transferrin transport (GO:0033572)2.85085053
82energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84270189
83ATP synthesis coupled proton transport (GO:0015986)2.84270189
84cell communication by electrical coupling (GO:0010644)2.81573058
85negative regulation of dendrite development (GO:2000171)2.80417207
86positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.80335203
87neurotransmitter transport (GO:0006836)2.79548291
88regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.78408212
89regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.77651735
90retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77061636
91heme biosynthetic process (GO:0006783)2.76393963
92sodium ion export (GO:0071436)2.76008677
93nucleobase catabolic process (GO:0046113)2.75425871
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75160628
95regulation of neurotransmitter levels (GO:0001505)2.74539102
96CTP metabolic process (GO:0046036)2.74228016
97CTP biosynthetic process (GO:0006241)2.74228016
98COPI coating of Golgi vesicle (GO:0048205)2.74051423
99Golgi transport vesicle coating (GO:0048200)2.74051423
100nucleobase-containing small molecule interconversion (GO:0015949)2.73853708
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73014159
102establishment of protein localization to mitochondrial membrane (GO:0090151)2.71839314
103glutamate metabolic process (GO:0006536)2.71133560
104viral protein processing (GO:0019082)2.70470062
105peroxisome fission (GO:0016559)2.69605686
106virion assembly (GO:0019068)2.69337639
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69085119
108respiratory electron transport chain (GO:0022904)2.68883518
109deoxyribonucleotide catabolic process (GO:0009264)2.68796148
110ribosomal small subunit biogenesis (GO:0042274)2.68645216
111peptidyl-arginine methylation (GO:0018216)2.68105297
112peptidyl-arginine N-methylation (GO:0035246)2.68105297
113layer formation in cerebral cortex (GO:0021819)2.67933805
114pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.67690927
115negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67619618
116deoxyribonucleotide biosynthetic process (GO:0009263)2.67120201
117nucleoside salvage (GO:0043174)2.66535940
118regulation of release of cytochrome c from mitochondria (GO:0090199)2.66176574
119cellular modified amino acid catabolic process (GO:0042219)2.66032371
120negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65267352
121regulation of cellular respiration (GO:0043457)2.64968382
122pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.64944559
123glyoxylate metabolic process (GO:0046487)2.64442459
124electron transport chain (GO:0022900)2.64162158
1252-deoxyribonucleotide metabolic process (GO:0009394)2.62954746
126cellular potassium ion homeostasis (GO:0030007)2.61840327
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.61354626
128mitochondrion transport along microtubule (GO:0047497)2.61354626
129purine deoxyribonucleotide metabolic process (GO:0009151)2.61338023
130pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.60820192
131cell communication involved in cardiac conduction (GO:0086065)2.60552436
132positive regulation of TOR signaling (GO:0032008)2.59878212
133prostaglandin biosynthetic process (GO:0001516)2.59768470
134prostanoid biosynthetic process (GO:0046457)2.59768470
135detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.59222681
136detection of temperature stimulus involved in sensory perception (GO:0050961)2.59222681
137negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58740205
138establishment of viral latency (GO:0019043)2.58433717
139sulfur amino acid catabolic process (GO:0000098)2.58163467
140regulation of cellular amino acid metabolic process (GO:0006521)2.58035819
141regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.57665811
142dicarboxylic acid catabolic process (GO:0043649)2.57249825
143antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.56802856
144maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56768232
145regulation of sodium ion transmembrane transporter activity (GO:2000649)2.56570625
146phagosome maturation (GO:0090382)2.55491861
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55142762
148de novo posttranslational protein folding (GO:0051084)2.54952795
149negative regulation of myeloid cell apoptotic process (GO:0033033)2.54705683
150UTP metabolic process (GO:0046051)2.54526028
151alpha-linolenic acid metabolic process (GO:0036109)2.53951391
152endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.53252944
153aerobic respiration (GO:0009060)2.52745685
154purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.52598848
155regulation of mitochondrion organization (GO:0010821)2.52378011
156proteasome assembly (GO:0043248)2.52122267
157membrane depolarization during action potential (GO:0086010)2.52079190
158ferric iron transport (GO:0015682)2.51960883
159ketone body metabolic process (GO:1902224)2.50295538
160aromatic amino acid family catabolic process (GO:0009074)2.47715182
161positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.47707637
162ATP hydrolysis coupled proton transport (GO:0015991)2.47399621
163energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.47399621
164gluconeogenesis (GO:0006094)2.45626785
165positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45303483
166neuron cell-cell adhesion (GO:0007158)2.43136665
167membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42914226
168cell migration in hindbrain (GO:0021535)2.42745929
169calcium-mediated signaling using intracellular calcium source (GO:0035584)2.42650988
170establishment of mitochondrion localization (GO:0051654)2.42253455
171synaptic vesicle endocytosis (GO:0048488)2.42108600
172short-chain fatty acid metabolic process (GO:0046459)2.41427566
173neurotransmitter-gated ion channel clustering (GO:0072578)2.40240992
174oxidative phosphorylation (GO:0006119)2.38137595
175positive regulation of synapse maturation (GO:0090129)2.38061917
176mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.37889909
177kynurenine metabolic process (GO:0070189)2.36040349
178axon cargo transport (GO:0008088)2.35851280
179synaptic transmission, glutamatergic (GO:0035249)2.35814773
180hexose biosynthetic process (GO:0019319)2.35723341
181adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.35710282
182nucleoside diphosphate biosynthetic process (GO:0009133)2.34443158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.42040781
2EZH2_22144423_ChIP-Seq_EOC_Human3.96359008
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.88231637
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60248330
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.75708223
6REST_18959480_ChIP-ChIP_MESCs_Mouse2.73204494
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.65535632
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62096752
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55426582
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.53397085
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.46009076
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44000019
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38266191
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37591153
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37418858
16ZNF263_19887448_ChIP-Seq_K562_Human2.37383928
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37064575
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.36340759
19VDR_21846776_ChIP-Seq_THP-1_Human2.21130803
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17952160
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06572465
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06098301
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05265211
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99987113
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97844768
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97151248
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93492227
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89319141
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.89026167
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.88149511
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87441905
32* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87089354
33* XRN2_22483619_ChIP-Seq_HELA_Human1.84707173
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.81589038
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.79961763
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78778531
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73267868
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71109918
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69883546
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69777449
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69118829
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.68647227
43* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68462008
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.68373125
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.67438722
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66604445
47GABP_19822575_ChIP-Seq_HepG2_Human1.61170800
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59517607
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58600073
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56192571
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55603170
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55603170
53LXR_22292898_ChIP-Seq_THP-1_Human1.54638407
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53816182
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.53764177
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49226533
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48300463
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48055314
59MYC_22102868_ChIP-Seq_BL_Human1.47602036
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47457763
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46754010
62RACK7_27058665_Chip-Seq_MCF-7_Human1.45904032
63ZNF274_21170338_ChIP-Seq_K562_Hela1.45533159
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45127395
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44617350
66DROSHA_22980978_ChIP-Seq_HELA_Human1.44230621
67CTCF_27219007_Chip-Seq_Bcells_Human1.42312432
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42218595
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41034277
70DCP1A_22483619_ChIP-Seq_HELA_Human1.39763533
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39104645
72* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38476687
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38139455
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36957240
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35747165
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34984303
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34029116
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34008181
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32798538
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32004959
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31536956
82MAF_26560356_Chip-Seq_TH2_Human1.31248841
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29056835
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28469323
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27853570
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27183837
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27053858
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25112365
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24904682
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24660000
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24108137
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23215490
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.22922476
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.21217524
95* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21156939
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.20337608
97* GABP_17652178_ChIP-ChIP_JURKAT_Human1.19714025
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19585111
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19409393
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.18955874
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18526593
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18342835
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18121893
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17999967
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16820609
106GATA1_22025678_ChIP-Seq_K562_Human1.15890632
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14837494
108CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13984276
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.12879241
110* CTCF_20526341_ChIP-Seq_ESCs_Human1.12461295
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11702989
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11428878
113* PHF8_20622854_ChIP-Seq_HELA_Human1.11313926
114KDM2B_26808549_Chip-Seq_DND41_Human1.11126444
115CTCF_21964334_Chip-Seq_Bcells_Human1.09954413
116KDM2B_26808549_Chip-Seq_K562_Human1.09803479
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09613292
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08671033
119* ELF1_20517297_ChIP-Seq_JURKAT_Human1.08452798
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08359139
121* MAF_26560356_Chip-Seq_TH1_Human1.07840155
122* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07090727
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07037649
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06795578
125ETS1_21867929_ChIP-Seq_TH2_Mouse1.06644641
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06188002
127* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06144741
128TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05938337
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05679338
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04915586
131P68_20966046_ChIP-Seq_HELA_Human1.04725274
132* YY1_22570637_ChIP-Seq_MALME-3M_Human1.04396701
133NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04215823
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02147272
135* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01877619
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00835278
137SOX2_21211035_ChIP-Seq_LN229_Human0.98951531
138SMC4_20622854_ChIP-Seq_HELA_Human0.98937414
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.98365686
140CREB1_26743006_Chip-Seq_LNCaP_Human0.95523196
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.95366078
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95104522
143* BCL6_27268052_Chip-Seq_Bcells_Human0.94013486
144* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92371273
145GBX2_23144817_ChIP-Seq_PC3_Human0.92187124
146EGR1_19032775_ChIP-ChIP_M12_Human0.91826665
147* SA1_27219007_Chip-Seq_Bcells_Human0.89802977
148TAF2_19829295_ChIP-Seq_ESCs_Human0.89480665
149FOXP1_21924763_ChIP-Seq_HESCs_Human0.89219444
150EED_16625203_ChIP-ChIP_MESCs_Mouse0.86922725
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.86500076
152RING1B_27294783_Chip-Seq_ESCs_Mouse0.84183852
153SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83894647
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.81293998
155SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.80023935
156OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79343671
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78478772
158OCT4_20526341_ChIP-Seq_ESCs_Human0.78176343
159HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76489215
160ESR2_21235772_ChIP-Seq_MCF-7_Human0.76471346
161* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76450954
162* BCOR_27268052_Chip-Seq_Bcells_Human0.76031167
163KLF4_19829295_ChIP-Seq_ESCs_Human0.74956343
164CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74657614
165GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74020390
166OCT4_19829295_ChIP-Seq_ESCs_Human0.73505888
167CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72753288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.64167627
2MP0005451_abnormal_body_composition3.85720759
3MP0002139_abnormal_hepatobiliary_system3.84901163
4MP0004270_analgesia3.21299574
5MP0001968_abnormal_touch/_nociception3.11472560
6MP0008260_abnormal_autophagy3.00379257
7MP0003635_abnormal_synaptic_transmissio2.94299528
8MP0005058_abnormal_lysosome_morphology2.93973652
9MP0003880_abnormal_central_pattern2.82233889
10MP0005360_urolithiasis2.77866238
11MP0002736_abnormal_nociception_after2.60541399
12MP0002735_abnormal_chemical_nociception2.58570015
13MP0002822_catalepsy2.47647551
14MP0003329_amyloid_beta_deposits2.46581747
15MP0005085_abnormal_gallbladder_physiolo2.46369502
16MP0002063_abnormal_learning/memory/cond2.37637367
17MP0002837_dystrophic_cardiac_calcinosis2.35780452
18MP0002653_abnormal_ependyma_morphology2.35165206
19MP0005365_abnormal_bile_salt2.33800548
20MP0009745_abnormal_behavioral_response2.27751754
21MP0002734_abnormal_mechanical_nocicepti2.24147703
22MP0008875_abnormal_xenobiotic_pharmacok2.23794948
23MP0006276_abnormal_autonomic_nervous2.23764979
24MP0002064_seizures2.22013089
25MP0005083_abnormal_biliary_tract2.16946939
26MP0004858_abnormal_nervous_system2.15274117
27MP0002733_abnormal_thermal_nociception2.11828061
28MP0002909_abnormal_adrenal_gland2.07134698
29MP0003303_peritoneal_inflammation2.01750856
30MP0009046_muscle_twitch1.91659263
31MP0003436_decreased_susceptibility_to1.91502147
32MP0002272_abnormal_nervous_system1.89560377
33MP0002572_abnormal_emotion/affect_behav1.79113899
34MP0002132_abnormal_respiratory_system1.78787583
35MP0009333_abnormal_splenocyte_physiolog1.75906973
36MP0001970_abnormal_pain_threshold1.75581795
37MP0004147_increased_porphyrin_level1.74738398
38MP0003186_abnormal_redox_activity1.73922340
39MP0004510_myositis1.72638476
40MP0006036_abnormal_mitochondrial_physio1.70767352
41MP0003191_abnormal_cellular_cholesterol1.68030640
42MP0005671_abnormal_response_to1.62103844
43MP0005332_abnormal_amino_acid1.60366578
44MP0008872_abnormal_physiological_respon1.58880222
45MP0002163_abnormal_gland_morphology1.57203181
46MP0003656_abnormal_erythrocyte_physiolo1.54130713
47MP0001984_abnormal_olfaction1.53606578
48MP0010329_abnormal_lipoprotein_level1.52490241
49MP0003806_abnormal_nucleotide_metabolis1.49200654
50MP0009840_abnormal_foam_cell1.48882928
51MP0004811_abnormal_neuron_physiology1.48846709
52MP0004924_abnormal_behavior1.48062987
53MP0005386_behavior/neurological_phenoty1.48062987
54MP0009780_abnormal_chondrocyte_physiolo1.43956510
55MP0001346_abnormal_lacrimal_gland1.43186433
56MP0004043_abnormal_pH_regulation1.43159948
57MP0002067_abnormal_sensory_capabilities1.42915192
58MP0000604_amyloidosis1.42212763
59MP0003123_paternal_imprinting1.41837828
60MP0004233_abnormal_muscle_weight1.41163109
61MP0001666_abnormal_nutrient_absorption1.40949675
62MP0002148_abnormal_hypersensitivity_rea1.36076602
63MP0005535_abnormal_body_temperature1.35495932
64MP0001440_abnormal_grooming_behavior1.35315880
65MP0000751_myopathy1.33948802
66MP0001501_abnormal_sleep_pattern1.33161376
67MP0009785_altered_susceptibility_to1.32401259
68MP0005025_abnormal_response_to1.31139149
69MP0005423_abnormal_somatic_nervous1.30935068
70MP0009278_abnormal_bone_marrow1.29648399
71MP0000858_altered_metastatic_potential1.29162755
72MP0002184_abnormal_innervation1.28916674
73MP0006035_abnormal_mitochondrial_morpho1.27843436
74MP0003646_muscle_fatigue1.25998569
75MP0003172_abnormal_lysosome_physiology1.25637229
76MP0000678_abnormal_parathyroid_gland1.24120325
77MP0006082_CNS_inflammation1.23958790
78MP0000490_abnormal_crypts_of1.23046931
79MP0008569_lethality_at_weaning1.23015450
80MP0005166_decreased_susceptibility_to1.22156137
81MP0001486_abnormal_startle_reflex1.21993605
82MP0000343_altered_response_to1.20678206
83MP0005584_abnormal_enzyme/coenzyme_acti1.20348421
84MP0005464_abnormal_platelet_physiology1.20332974
85MP0001905_abnormal_dopamine_level1.20079431
86MP0003879_abnormal_hair_cell1.19450930
87MP0001529_abnormal_vocalization1.18699486
88* MP0005000_abnormal_immune_tolerance1.17301083
89MP0001348_abnormal_lacrimal_gland1.15623462
90MP0002557_abnormal_social/conspecific_i1.14721379
91MP0003633_abnormal_nervous_system1.13350890
92MP0003195_calcinosis1.11362073
93MP0005623_abnormal_meninges_morphology1.11317699
94MP0002118_abnormal_lipid_homeostasis1.10808153
95MP0000750_abnormal_muscle_regeneration1.10780423
96MP0002066_abnormal_motor_capabilities/c1.10762805
97MP0004885_abnormal_endolymph1.10053936
98MP0000955_abnormal_spinal_cord1.09868493
99MP0004130_abnormal_muscle_cell1.08276680
100MP0004142_abnormal_muscle_tone1.07281346
101MP0000358_abnormal_cell_content/1.06490002
102MP0002419_abnormal_innate_immunity1.02351767
103MP0004145_abnormal_muscle_electrophysio1.02046912
104MP0001835_abnormal_antigen_presentation1.01903608
105MP0000681_abnormal_thyroid_gland1.01684444
106MP0004215_abnormal_myocardial_fiber1.01613939
107MP0005636_abnormal_mineral_homeostasis1.00734540
108MP0001727_abnormal_embryo_implantation0.99748235
109MP0008874_decreased_physiological_sensi0.99526707
110MP0002420_abnormal_adaptive_immunity0.96619145
111MP0001819_abnormal_immune_cell0.94481666
112* MP0002723_abnormal_immune_serum0.94333851
113MP0005319_abnormal_enzyme/_coenzyme0.92327031
114MP0000747_muscle_weakness0.92015898
115MP0000685_abnormal_immune_system0.91906005
116MP0002078_abnormal_glucose_homeostasis0.89924586
117MP0008961_abnormal_basal_metabolism0.89135139
118MP0000013_abnormal_adipose_tissue0.88868005
119MP0003631_nervous_system_phenotype0.87994722
120MP0003634_abnormal_glial_cell0.86867697
121MP0002229_neurodegeneration0.86728330
122MP0004185_abnormal_adipocyte_glucose0.86470565
123MP0002882_abnormal_neuron_morphology0.86112093
124MP0005379_endocrine/exocrine_gland_phen0.84811910
125MP0000920_abnormal_myelination0.84660584
126MP0005084_abnormal_gallbladder_morpholo0.84185515
127MP0005394_taste/olfaction_phenotype0.84116569
128MP0005499_abnormal_olfactory_system0.84116569
129MP0000749_muscle_degeneration0.84085278
130MP0003252_abnormal_bile_duct0.83572664
131MP0010234_abnormal_vibrissa_follicle0.82508797
132MP0000778_abnormal_nervous_system0.81352313
133MP0003283_abnormal_digestive_organ0.81232259
134MP0002138_abnormal_hepatobiliary_system0.81149191
135MP0002277_abnormal_respiratory_mucosa0.80944134
136MP0002069_abnormal_eating/drinking_beha0.80889717
137MP0009643_abnormal_urine_homeostasis0.79538252
138MP0001765_abnormal_ion_homeostasis0.79119725
139MP0003693_abnormal_embryo_hatching0.78796111
140MP0008469_abnormal_protein_level0.78544944
141MP0005501_abnormal_skin_physiology0.78337209
142MP0002269_muscular_atrophy0.78215037
143MP0005165_increased_susceptibility_to0.78143263
144MP0002452_abnormal_antigen_presenting0.77789333
145* MP0002398_abnormal_bone_marrow0.76721183
146MP0004085_abnormal_heartbeat0.76378111
147MP0005646_abnormal_pituitary_gland0.76128362
148MP0008789_abnormal_olfactory_epithelium0.75960649
149MP0000465_gastrointestinal_hemorrhage0.75893674
150MP0004036_abnormal_muscle_relaxation0.75645996
151MP0005167_abnormal_blood-brain_barrier0.74506780
152MP0003137_abnormal_impulse_conducting0.74478130
153MP0005330_cardiomyopathy0.74266195
154MP0009764_decreased_sensitivity_to0.73664687
155MP0003868_abnormal_feces_composition0.73279161
156MP0003075_altered_response_to0.72621663
157MP0000759_abnormal_skeletal_muscle0.72129945
158MP0002876_abnormal_thyroid_physiology0.71889662
159MP0001764_abnormal_homeostasis0.71474515
160MP0001853_heart_inflammation0.71336661
161* MP0002429_abnormal_blood_cell0.71105617
162MP0001756_abnormal_urination0.71070885
163* MP0000716_abnormal_immune_system0.70957393

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.95710284
2Focal motor seizures (HP:0011153)4.12475583
3Visual hallucinations (HP:0002367)4.10333765
4Increased intramyocellular lipid droplets (HP:0012240)4.05102866
5Increased muscle lipid content (HP:0009058)3.81589256
6Pheochromocytoma (HP:0002666)3.56665264
7Abnormality of glycolipid metabolism (HP:0010969)3.47949217
8Abnormality of liposaccharide metabolism (HP:0010968)3.47949217
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.47949217
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32770796
11Neuroendocrine neoplasm (HP:0100634)3.32245448
12Gout (HP:0001997)3.27789496
13Focal seizures (HP:0007359)3.07322160
14Ketosis (HP:0001946)3.03390377
15Ketoacidosis (HP:0001993)2.96150565
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.95726382
17Exercise intolerance (HP:0003546)2.95093766
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94449216
19Abnormal mitochondria in muscle tissue (HP:0008316)2.85370073
20Acute encephalopathy (HP:0006846)2.81924375
21Ankle clonus (HP:0011448)2.80169575
22Poor eye contact (HP:0000817)2.75558910
23Absence seizures (HP:0002121)2.68597952
24Impaired social interactions (HP:0000735)2.67186313
25Abnormal social behavior (HP:0012433)2.67186313
26Microretrognathia (HP:0000308)2.66372555
27Hyperammonemia (HP:0001987)2.62004467
28Acute necrotizing encephalopathy (HP:0006965)2.60663096
29Abnormal gallbladder physiology (HP:0012438)2.60602544
30Cholecystitis (HP:0001082)2.60602544
31Anxiety (HP:0000739)2.60405879
32Supranuclear gaze palsy (HP:0000605)2.60250691
33Atonic seizures (HP:0010819)2.59382245
34Neuronal loss in central nervous system (HP:0002529)2.56782483
35Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53792251
36Hyperventilation (HP:0002883)2.51839613
37Mutism (HP:0002300)2.50951609
38Epileptic encephalopathy (HP:0200134)2.49871158
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49424710
40Hyperglycinemia (HP:0002154)2.49209250
41Myopathic facies (HP:0002058)2.49082759
42Nasal polyposis (HP:0100582)2.47902496
43Increased IgM level (HP:0003496)2.46884692
44Depression (HP:0000716)2.46396424
45Progressive muscle weakness (HP:0003323)2.45749776
46Hypertensive crisis (HP:0100735)2.42945925
47Increased hepatocellular lipid droplets (HP:0006565)2.42649925
48Cerebral edema (HP:0002181)2.41455387
49Generalized tonic-clonic seizures (HP:0002069)2.39176445
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38740203
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38740203
52Delusions (HP:0000746)2.38575298
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.38067791
54Testicular atrophy (HP:0000029)2.36698365
55Progressive neurologic deterioration (HP:0002344)2.35829361
56Renal Fanconi syndrome (HP:0001994)2.34285128
57Hepatic necrosis (HP:0002605)2.33144679
58Dialeptic seizures (HP:0011146)2.31834226
59Hepatocellular necrosis (HP:0001404)2.30774789
60Neoplasm of the peripheral nervous system (HP:0100007)2.30622565
61Cholelithiasis (HP:0001081)2.26311988
62Hyperglycinuria (HP:0003108)2.26197926
63Lipid accumulation in hepatocytes (HP:0006561)2.25759593
64Action tremor (HP:0002345)2.24455585
65Focal dystonia (HP:0004373)2.24151885
66Distal lower limb muscle weakness (HP:0009053)2.23403974
67Abnormality of the nasal mucosa (HP:0000433)2.22602836
68Urinary urgency (HP:0000012)2.22323321
69Lactic acidosis (HP:0003128)2.22108071
70Abnormality of the lower motor neuron (HP:0002366)2.22078277
71Ventricular fibrillation (HP:0001663)2.21886121
72Impaired vibration sensation in the lower limbs (HP:0002166)2.21556415
73Vertebral compression fractures (HP:0002953)2.21439873
74Craniofacial dystonia (HP:0012179)2.21213509
75Mitochondrial inheritance (HP:0001427)2.20938376
76Global brain atrophy (HP:0002283)2.19904727
77Abnormal eating behavior (HP:0100738)2.19430140
78Myoglobinuria (HP:0002913)2.19347223
79Status epilepticus (HP:0002133)2.19279197
80Increased serum lactate (HP:0002151)2.18580756
81Exercise-induced myalgia (HP:0003738)2.17933007
82Ragged-red muscle fibers (HP:0003200)2.17511502
83Cerebral hypomyelination (HP:0006808)2.17458559
84Microvesicular hepatic steatosis (HP:0001414)2.16949367
85Progressive macrocephaly (HP:0004481)2.16590837
86Neonatal onset (HP:0003623)2.15679592
87Growth hormone excess (HP:0000845)2.14661414
88Abnormal gallbladder morphology (HP:0012437)2.14048067
89Upper motor neuron abnormality (HP:0002127)2.13842760
90Progressive inability to walk (HP:0002505)2.12967372
91Obstructive lung disease (HP:0006536)2.12784131
92Chronic obstructive pulmonary disease (HP:0006510)2.12784131
93Xanthomatosis (HP:0000991)2.12210191
94Abnormality of glycine metabolism (HP:0010895)2.11366528
95Abnormality of serine family amino acid metabolism (HP:0010894)2.11366528
96Loss of speech (HP:0002371)2.11120369
97Degeneration of anterior horn cells (HP:0002398)2.11028578
98Abnormality of the anterior horn cell (HP:0006802)2.11028578
993-Methylglutaconic aciduria (HP:0003535)2.10777721
100Hypobetalipoproteinemia (HP:0003563)2.10726682
101Respiratory failure (HP:0002878)2.10693238
102Respiratory difficulties (HP:0002880)2.09401138
103Delayed CNS myelination (HP:0002188)2.09094539
104Lethargy (HP:0001254)2.08951930
105Petechiae (HP:0000967)2.08205952
106Torticollis (HP:0000473)2.08020603
107Hyperlipoproteinemia (HP:0010980)2.06309062
108Diminished motivation (HP:0000745)2.06285612
109Abnormality of the motor neurons (HP:0002450)2.05830857
110Abnormal neuron morphology (HP:0012757)2.05830857
111Hypsarrhythmia (HP:0002521)2.04148329
112Metabolic acidosis (HP:0001942)2.03584719
113Rhabdomyolysis (HP:0003201)2.03573181
114Intrahepatic cholestasis (HP:0001406)2.02821647
115Myotonia (HP:0002486)2.02672704
116Poor suck (HP:0002033)2.02583963
117EEG with generalized epileptiform discharges (HP:0011198)2.02415863
118Increased CSF lactate (HP:0002490)2.01538466
119Epileptiform EEG discharges (HP:0011182)2.01236463
120Abnormality of fatty-acid metabolism (HP:0004359)2.01179407
121Purpura (HP:0000979)2.01157496
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00698964
123Abnormality of the Achilles tendon (HP:0005109)2.00499838
124Palpitations (HP:0001962)2.00173150
125Achilles tendon contracture (HP:0001771)1.99850731
126Impaired pain sensation (HP:0007328)1.98954304
127Abnormality of pain sensation (HP:0010832)1.98954304
128Hand muscle atrophy (HP:0009130)1.98459697
129Truncal ataxia (HP:0002078)1.96494358
130Muscular hypotonia of the trunk (HP:0008936)1.96147689
131Febrile seizures (HP:0002373)1.95180078
132Apathy (HP:0000741)1.94461294
133Emotional lability (HP:0000712)1.92996949
134Abnormality of macrophages (HP:0004311)1.92529818
135Polyphagia (HP:0002591)1.91796347
136Upper limb amyotrophy (HP:0009129)1.90728463
137Distal upper limb amyotrophy (HP:0007149)1.90728463
138Bradykinesia (HP:0002067)1.90018543
139Deep venous thrombosis (HP:0002625)1.89910491
140Tetraplegia (HP:0002445)1.89834454
141Athetosis (HP:0002305)1.89264949
142Dysphonia (HP:0001618)1.89169848
143Progressive microcephaly (HP:0000253)1.89166160
144Oligomenorrhea (HP:0000876)1.88813872
145Multiple enchondromatosis (HP:0005701)1.87488503
146Late onset (HP:0003584)1.85967162
147Mediastinal lymphadenopathy (HP:0100721)1.84632457
148Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84449691
149Dicarboxylic aciduria (HP:0003215)1.84449691
150Hyperbilirubinemia (HP:0002904)1.84211830
151Fatigue (HP:0012378)1.84099761
152Spastic gait (HP:0002064)1.84076576
153Abnormality of the vocal cords (HP:0008777)1.83864568
154Unsteady gait (HP:0002317)1.83819559
155Amblyopia (HP:0000646)1.83392645
156Hypoglycemic coma (HP:0001325)1.83354003
157Progressive cerebellar ataxia (HP:0002073)1.83138605
158Atrophy/Degeneration involving motor neurons (HP:0007373)1.82502053
159Hepatosplenomegaly (HP:0001433)1.82410647
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.81501544
161Abnormal respiratory motile cilium physiology (HP:0012261)1.79741719
162Neurofibrillary tangles (HP:0002185)1.79631947
163Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79613053
164Truncus arteriosus (HP:0001660)1.79295553
165Hyperthyroidism (HP:0000836)1.79165892
166Amyloidosis (HP:0011034)1.77656069
167Abnormal respiratory motile cilium morphology (HP:0005938)1.74837500
168Abnormal respiratory epithelium morphology (HP:0012253)1.74837500
169Dementia (HP:0000726)1.73494716
170Gliosis (HP:0002171)1.72919887
171Dysostosis multiplex (HP:0000943)1.72259645
172Abnormality of glycolysis (HP:0004366)1.72013766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.03241206
2NME23.77285769
3MAP3K93.75168210
4NTRK33.31482462
5LMTK23.29013864
6MINK13.07767221
7MAP3K123.00613275
8MAP3K42.72550351
9MAP2K42.65549306
10DAPK22.62172375
11BCKDK2.60569134
12KSR22.54553438
13MARK12.50766384
14PIM22.30574113
15NTRK12.25451679
16MAP2K72.24821573
17EPHA42.20342431
18TAOK22.12422917
19SCYL21.99409932
20VRK21.89457155
21DAPK11.88045944
22PRPF4B1.84562663
23ARAF1.84389458
24KSR11.83861615
25IRAK31.77550276
26MAP3K21.76732683
27KDR1.75310464
28PINK11.75045341
29SMG11.70926256
30CDK191.62826990
31NEK11.62203940
32GRK51.61016107
33STK161.57101100
34NME11.56330526
35PHKG21.49558202
36PHKG11.49558202
37RIPK41.41667914
38PAK61.39338035
39CDK51.36793673
40SIK31.34387097
41TBK11.28609280
42MAP4K11.25432639
43CAMKK11.23495979
44EIF2AK11.22795417
45MAP3K111.21572932
46NTRK21.19976421
47RET1.16658392
48PRKCG1.12695753
49MAP2K31.11987958
50PRKD31.11725571
51TLK11.07400640
52AURKA1.03350694
53TRIB31.02217557
54UHMK11.01872016
55WNK40.99894020
56BUB10.99837165
57FES0.98551831
58MAP2K10.96171691
59STK380.95053609
60DYRK1B0.93472267
61MAP3K30.91775294
62LATS20.90652916
63MAP3K10.89249964
64SRPK10.87476036
65PAK40.87132195
66PRKD20.86557630
67DAPK30.86049062
68LIMK10.84704940
69LRRK20.82309273
70MAP2K60.82244900
71PAK10.81457469
72CSNK1G30.81148947
73CDK140.78788639
74GRK60.77664862
75CDK180.77396655
76MAPKAPK30.76839534
77RAF10.76739538
78MATK0.76024489
79PDPK10.75328374
80TAOK10.74340445
81SGK2230.74150266
82SGK4940.74150266
83PDK30.69706225
84PDK40.69706225
85CDK150.69489386
86CAMK2G0.69251266
87CAMKK20.68992827
88PDK10.65371167
89MARK20.62557348
90PRKCH0.62104371
91CDK11A0.61967638
92PKN10.61846678
93SIK20.61458430
94PTK2B0.60525222
95ILK0.60509901
96EPHA20.60335822
97PRKCZ0.60094621
98BRAF0.59330548
99ABL20.59262699
100ICK0.59230456
101TYK20.57506019
102CAMK2A0.57482788
103MAP3K50.57362891
104PLK20.57147212
105MAPK130.54362786
106CSK0.53867577
107PRKG20.52550519
108IRAK20.51785113
109CSNK1G20.51643422
110PAK30.51077666
111PKN20.50697085
112MAP2K20.50520434
113CAMK2B0.50489015
114CSNK1A1L0.48627561
115IRAK40.47534664
116OXSR10.47387270
117ERN10.47360879
118AKT20.46931032
119CAMK10.44693485
120TESK10.44529671
121MAP3K70.43474617
122WNK30.43345360
123STK240.42686296
124MAPK120.42481860
125MOS0.42406352
126RPS6KA20.42192908
127CAMK2D0.39444169
128MAP3K130.39338790
129CCNB10.38584649
130PRKACG0.38455891
131MAP3K80.37540481
132FGR0.36505006
133STK110.35096534
134TRIM280.34861760
135FER0.34814049
136PBK0.34728479
137PRKCD0.33945202
138MAPKAPK50.33906737
139DYRK1A0.32639410
140PRKCI0.32325455
141BCR0.32255950
142PNCK0.31526093
143MYLK0.31304263
144DYRK20.30213844
145EPHB10.29871248
146TNK20.26116958

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.19362178
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98228146
3Synaptic vesicle cycle_Homo sapiens_hsa047212.88787157
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.82362518
5Ribosome_Homo sapiens_hsa030102.34488368
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29973117
7Nitrogen metabolism_Homo sapiens_hsa009102.20342707
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13160529
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05764212
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04830890
11Oxidative phosphorylation_Homo sapiens_hsa001901.99156118
12Parkinsons disease_Homo sapiens_hsa050121.96198696
13Butanoate metabolism_Homo sapiens_hsa006501.94468577
14Base excision repair_Homo sapiens_hsa034101.93879024
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.87828789
16Olfactory transduction_Homo sapiens_hsa047401.85849668
17Propanoate metabolism_Homo sapiens_hsa006401.83151992
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76793461
19Arginine biosynthesis_Homo sapiens_hsa002201.76455652
20DNA replication_Homo sapiens_hsa030301.74373565
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65092616
22Pyruvate metabolism_Homo sapiens_hsa006201.64768925
23Nicotine addiction_Homo sapiens_hsa050331.59998518
24GABAergic synapse_Homo sapiens_hsa047271.56082675
25Cardiac muscle contraction_Homo sapiens_hsa042601.53278905
26Collecting duct acid secretion_Homo sapiens_hsa049661.52520703
27Long-term potentiation_Homo sapiens_hsa047201.51615862
28Other glycan degradation_Homo sapiens_hsa005111.51091592
29Fatty acid degradation_Homo sapiens_hsa000711.49687558
30Fatty acid elongation_Homo sapiens_hsa000621.46854449
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45676485
32Pyrimidine metabolism_Homo sapiens_hsa002401.43648065
33Alzheimers disease_Homo sapiens_hsa050101.42207596
34Carbon metabolism_Homo sapiens_hsa012001.41546876
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41536582
36Bile secretion_Homo sapiens_hsa049761.39440002
37Insulin secretion_Homo sapiens_hsa049111.36950294
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35121296
39RNA polymerase_Homo sapiens_hsa030201.35036472
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34048214
41Circadian entrainment_Homo sapiens_hsa047131.33941213
42Vitamin B6 metabolism_Homo sapiens_hsa007501.32928946
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32655277
44Dopaminergic synapse_Homo sapiens_hsa047281.31856711
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31160101
46Amphetamine addiction_Homo sapiens_hsa050311.30416992
47Shigellosis_Homo sapiens_hsa051311.23854092
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18263918
49Lysosome_Homo sapiens_hsa041421.17301446
50Salmonella infection_Homo sapiens_hsa051321.16784944
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.15930249
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15803820
53Tryptophan metabolism_Homo sapiens_hsa003801.14320091
54Fatty acid metabolism_Homo sapiens_hsa012121.13569501
55Sulfur metabolism_Homo sapiens_hsa009201.12886085
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09410002
57Glutamatergic synapse_Homo sapiens_hsa047241.09095986
58Spliceosome_Homo sapiens_hsa030401.08763876
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07317428
60Biosynthesis of amino acids_Homo sapiens_hsa012301.07298050
61Peroxisome_Homo sapiens_hsa041461.05797140
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05674660
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.05381732
64Sulfur relay system_Homo sapiens_hsa041221.04906643
65Morphine addiction_Homo sapiens_hsa050321.04651668
66Huntingtons disease_Homo sapiens_hsa050161.01957374
67Gastric acid secretion_Homo sapiens_hsa049711.01708954
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00677160
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96074629
70Salivary secretion_Homo sapiens_hsa049700.94213938
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94074335
72Mismatch repair_Homo sapiens_hsa034300.92677352
73Vibrio cholerae infection_Homo sapiens_hsa051100.91762658
74Endocytosis_Homo sapiens_hsa041440.91646730
75Glutathione metabolism_Homo sapiens_hsa004800.90560082
76beta-Alanine metabolism_Homo sapiens_hsa004100.89808271
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87963391
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87560127
79Cholinergic synapse_Homo sapiens_hsa047250.87557595
80Rheumatoid arthritis_Homo sapiens_hsa053230.86824730
81Taste transduction_Homo sapiens_hsa047420.85302244
82Primary immunodeficiency_Homo sapiens_hsa053400.85000971
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84568769
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82768392
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81043017
86PPAR signaling pathway_Homo sapiens_hsa033200.80131570
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.79715258
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79265881
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.72729449
90Starch and sucrose metabolism_Homo sapiens_hsa005000.72581389
91Phagosome_Homo sapiens_hsa041450.70316454
92Cocaine addiction_Homo sapiens_hsa050300.70215470
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69900703
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68973470
95Folate biosynthesis_Homo sapiens_hsa007900.67541554
96Epstein-Barr virus infection_Homo sapiens_hsa051690.67111423
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65850651
98Phenylalanine metabolism_Homo sapiens_hsa003600.64996780
99Oxytocin signaling pathway_Homo sapiens_hsa049210.63985457
100Glycerolipid metabolism_Homo sapiens_hsa005610.63486241
101Glucagon signaling pathway_Homo sapiens_hsa049220.63388172
102Pancreatic secretion_Homo sapiens_hsa049720.63364373
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62946029
104Fat digestion and absorption_Homo sapiens_hsa049750.61927360
105Gap junction_Homo sapiens_hsa045400.60954620
106Calcium signaling pathway_Homo sapiens_hsa040200.60403250
107Renin secretion_Homo sapiens_hsa049240.59752637
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59685597
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57917584
110Apoptosis_Homo sapiens_hsa042100.57887696
111GnRH signaling pathway_Homo sapiens_hsa049120.57203727
112Fructose and mannose metabolism_Homo sapiens_hsa000510.56999972
113Insulin signaling pathway_Homo sapiens_hsa049100.56668887
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56093772
115N-Glycan biosynthesis_Homo sapiens_hsa005100.54655366
116Tuberculosis_Homo sapiens_hsa051520.54315716
117Type II diabetes mellitus_Homo sapiens_hsa049300.52822651
118Prion diseases_Homo sapiens_hsa050200.51741601
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50124523
120Long-term depression_Homo sapiens_hsa047300.49905874
121Galactose metabolism_Homo sapiens_hsa000520.49187381
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48045761
123Osteoclast differentiation_Homo sapiens_hsa043800.47117585
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46997908
125Purine metabolism_Homo sapiens_hsa002300.46092569
126Serotonergic synapse_Homo sapiens_hsa047260.45956795
127Pentose phosphate pathway_Homo sapiens_hsa000300.45215263
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44950457
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.44675184
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43989269
131Estrogen signaling pathway_Homo sapiens_hsa049150.40460107
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40396307
133Nucleotide excision repair_Homo sapiens_hsa034200.40384708
134Tyrosine metabolism_Homo sapiens_hsa003500.40322655
135VEGF signaling pathway_Homo sapiens_hsa043700.39963537
136Oocyte meiosis_Homo sapiens_hsa041140.38702268
137Arginine and proline metabolism_Homo sapiens_hsa003300.37509420
138Regulation of autophagy_Homo sapiens_hsa041400.36384658
139Metabolic pathways_Homo sapiens_hsa011000.35826667
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35810587
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35722759
142Chemical carcinogenesis_Homo sapiens_hsa052040.35496340
143Legionellosis_Homo sapiens_hsa051340.35133950
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35089366
145Herpes simplex infection_Homo sapiens_hsa051680.33222159
146Viral myocarditis_Homo sapiens_hsa054160.32252114
147Leishmaniasis_Homo sapiens_hsa051400.31549668
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30866897
149Allograft rejection_Homo sapiens_hsa053300.30459251
150Autoimmune thyroid disease_Homo sapiens_hsa053200.30201643
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.29056350
152Bladder cancer_Homo sapiens_hsa052190.28927985
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28489398
154Antigen processing and presentation_Homo sapiens_hsa046120.25990290
155Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25651686
156Alcoholism_Homo sapiens_hsa050340.22709063

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