TUSC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68014954
2synaptic vesicle exocytosis (GO:0016079)5.19118525
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11303772
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99848452
5synaptic vesicle maturation (GO:0016188)4.94743687
6vocalization behavior (GO:0071625)4.78290455
7neuron cell-cell adhesion (GO:0007158)4.74733370
8regulation of synaptic vesicle exocytosis (GO:2000300)4.73602151
9protein localization to synapse (GO:0035418)4.67597765
10glutamate secretion (GO:0014047)4.63242897
11regulation of glutamate receptor signaling pathway (GO:1900449)4.50590213
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.49765808
13locomotory exploration behavior (GO:0035641)4.48999409
14regulation of synaptic vesicle transport (GO:1902803)4.21952399
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.16762222
16layer formation in cerebral cortex (GO:0021819)4.03162919
17neuron recognition (GO:0008038)3.94702459
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.89378406
19exploration behavior (GO:0035640)3.88013103
20regulation of synapse structural plasticity (GO:0051823)3.87229263
21regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85872551
22regulation of neuronal synaptic plasticity (GO:0048168)3.82984766
23neuronal action potential propagation (GO:0019227)3.81009302
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80354108
25neurotransmitter secretion (GO:0007269)3.76758111
26glutamate receptor signaling pathway (GO:0007215)3.69369817
27epithelial cilium movement (GO:0003351)3.68137660
28synaptic transmission, glutamatergic (GO:0035249)3.63087111
29synaptic vesicle endocytosis (GO:0048488)3.60539635
30dendritic spine morphogenesis (GO:0060997)3.60438625
31axonal fasciculation (GO:0007413)3.57872302
32cilium movement (GO:0003341)3.55555296
33proline transport (GO:0015824)3.54770079
34neurotransmitter-gated ion channel clustering (GO:0072578)3.54608662
35neuron-neuron synaptic transmission (GO:0007270)3.54547854
36positive regulation of synapse maturation (GO:0090129)3.47814252
37pyrimidine nucleobase catabolic process (GO:0006208)3.47705543
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44328133
39innervation (GO:0060384)3.43242669
40axonemal dynein complex assembly (GO:0070286)3.42878169
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39815003
42activation of protein kinase A activity (GO:0034199)3.39039559
43postsynaptic membrane organization (GO:0001941)3.35673415
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.34663400
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31172943
46regulation of vesicle fusion (GO:0031338)3.29914829
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.25851549
48long-term synaptic potentiation (GO:0060291)3.23983402
49regulation of postsynaptic membrane potential (GO:0060078)3.23070089
50cellular potassium ion homeostasis (GO:0030007)3.22442248
51intraciliary transport (GO:0042073)3.20322624
52positive regulation of membrane potential (GO:0045838)3.18701399
53regulation of synaptic plasticity (GO:0048167)3.17874162
54response to auditory stimulus (GO:0010996)3.17715123
55detection of calcium ion (GO:0005513)3.16385712
56regulation of dendritic spine morphogenesis (GO:0061001)3.16349593
57transmission of nerve impulse (GO:0019226)3.16148159
58regulation of neurotransmitter secretion (GO:0046928)3.15585655
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11670519
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09841564
61adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.09439782
62response to histamine (GO:0034776)3.09143222
63auditory behavior (GO:0031223)3.08739300
64presynaptic membrane assembly (GO:0097105)3.08327685
65neurotransmitter transport (GO:0006836)3.08037012
66behavioral defense response (GO:0002209)3.08016399
67behavioral fear response (GO:0001662)3.08016399
68dendrite morphogenesis (GO:0048813)3.05341635
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05335978
70long-term memory (GO:0007616)3.04028140
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03026817
72synapse assembly (GO:0007416)3.02659117
73nucleobase catabolic process (GO:0046113)3.02417891
74retinal ganglion cell axon guidance (GO:0031290)2.99911911
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98962843
76calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.98950129
77fear response (GO:0042596)2.98751517
78negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95112018
79positive regulation of neurotransmitter secretion (GO:0001956)2.94940764
80vesicle transport along microtubule (GO:0047496)2.93592608
81nonmotile primary cilium assembly (GO:0035058)2.93452131
82response to pheromone (GO:0019236)2.90631687
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90323381
84regulation of neurotransmitter transport (GO:0051588)2.89784481
85dopamine receptor signaling pathway (GO:0007212)2.89660813
86establishment of synaptic vesicle localization (GO:0097480)2.88135083
87synaptic vesicle transport (GO:0048489)2.88135083
88regulation of glutamate secretion (GO:0014048)2.88043073
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87678777
90mating behavior (GO:0007617)2.87641092
91dendritic spine organization (GO:0097061)2.87584923
92positive regulation of synapse assembly (GO:0051965)2.85637440
93cell communication by electrical coupling (GO:0010644)2.85624961
94regulation of female receptivity (GO:0045924)2.85412379
95female mating behavior (GO:0060180)2.82316614
96regulation of neurotransmitter levels (GO:0001505)2.81804127
97gamma-aminobutyric acid transport (GO:0015812)2.81499919
98axoneme assembly (GO:0035082)2.81473515
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81042014
100positive regulation of neurotransmitter transport (GO:0051590)2.80585560
101membrane depolarization (GO:0051899)2.79715694
102positive regulation of synaptic transmission (GO:0050806)2.79483367
103presynaptic membrane organization (GO:0097090)2.79184746
104synaptic transmission (GO:0007268)2.78591754
105membrane depolarization during action potential (GO:0086010)2.78456833
106establishment of vesicle localization (GO:0051650)2.77895425
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.77576038
108regulation of calcium ion-dependent exocytosis (GO:0017158)2.77468738
109synapse organization (GO:0050808)2.77164657
110regulation of synapse maturation (GO:0090128)2.76925462
111cell migration in hindbrain (GO:0021535)2.76857894
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70978070
113negative regulation of axon guidance (GO:1902668)2.70425020
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.70125043
115axon extension involved in axon guidance (GO:0048846)2.70125043
116protein localization to cilium (GO:0061512)2.69610734
117regulation of cilium movement (GO:0003352)2.68523289
118cilium assembly (GO:0042384)2.68353214
119cilium organization (GO:0044782)2.65783965
120left/right pattern formation (GO:0060972)2.65536784
121cilium or flagellum-dependent cell motility (GO:0001539)2.63522188
122paraxial mesoderm development (GO:0048339)2.62604894
123ganglion development (GO:0061548)2.58532849
124positive regulation of mitochondrial fission (GO:0090141)2.52829473
125cilium morphogenesis (GO:0060271)2.52555248
126axon extension (GO:0048675)2.37854505
127establishment of nucleus localization (GO:0040023)2.33052311
128microtubule bundle formation (GO:0001578)2.32985079
129negative regulation of axon extension involved in axon guidance (GO:0048843)2.32812592
130regulation of axon guidance (GO:1902667)2.30364276
131establishment of planar polarity (GO:0001736)2.23985462
132establishment of tissue polarity (GO:0007164)2.23985462
133cellular component assembly involved in morphogenesis (GO:0010927)2.22937386
134appendage development (GO:0048736)2.22719048
135limb development (GO:0060173)2.22719048
136motile cilium assembly (GO:0044458)2.17842767
137mechanosensory behavior (GO:0007638)2.16292327
138smoothened signaling pathway (GO:0007224)2.15244211
139inner ear receptor cell development (GO:0060119)2.14944120
140cytoskeleton-dependent intracellular transport (GO:0030705)2.14845561
141neurofilament cytoskeleton organization (GO:0060052)2.13841469
142protein polyglutamylation (GO:0018095)2.13463840
143microtubule-based transport (GO:0010970)2.12140765
144establishment of mitochondrion localization (GO:0051654)2.11027001
145olfactory bulb development (GO:0021772)2.10686591
146regulation of type B pancreatic cell apoptotic process (GO:2000674)2.10567172
147microtubule-based movement (GO:0007018)2.08957222
148neuronal ion channel clustering (GO:0045161)2.07674969
149homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.07338173
150regulation of microtubule-based movement (GO:0060632)2.06890495
151determination of bilateral symmetry (GO:0009855)2.05704709
152establishment or maintenance of monopolar cell polarity (GO:0061339)2.05697782
153establishment of monopolar cell polarity (GO:0061162)2.05697782
154behavioral response to nicotine (GO:0035095)2.05658848
155substrate-independent telencephalic tangential migration (GO:0021826)2.03409871
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.03409871
157glycosphingolipid biosynthetic process (GO:0006688)2.03253697
158apical protein localization (GO:0045176)2.02980065
159brain morphogenesis (GO:0048854)2.02643885
160short-term memory (GO:0007614)2.02634502
161regulation of axon extension involved in axon guidance (GO:0048841)2.02455387
162chemosensory behavior (GO:0007635)2.02164902
163determination of left/right symmetry (GO:0007368)2.02008094
164regulation of synapse assembly (GO:0051963)2.01694540
165response to dietary excess (GO:0002021)2.01652359
166specification of symmetry (GO:0009799)1.99813773
167negative chemotaxis (GO:0050919)1.98968068
168cerebellum development (GO:0021549)1.98299355
169establishment of melanosome localization (GO:0032401)1.97930945
170body morphogenesis (GO:0010171)1.96249664
171glycerophospholipid catabolic process (GO:0046475)1.95295126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.03594656
2GBX2_23144817_ChIP-Seq_PC3_Human3.60146394
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12606851
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00962437
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00214768
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68149421
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.66834703
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65411892
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.64534624
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63089104
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63089104
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58660098
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55255872
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52073214
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48074550
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46861203
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44575099
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.39296718
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27735386
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.26177118
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.26025225
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24595824
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24543568
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.15771519
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.13957386
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06478725
27DROSHA_22980978_ChIP-Seq_HELA_Human2.05469338
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96374512
29TAF15_26573619_Chip-Seq_HEK293_Human1.86960771
30ZNF274_21170338_ChIP-Seq_K562_Hela1.84318624
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81456196
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81082043
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77690118
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71906260
35AR_21572438_ChIP-Seq_LNCaP_Human1.67195160
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.66633813
37SMAD4_21799915_ChIP-Seq_A2780_Human1.64919970
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62967506
39IGF1R_20145208_ChIP-Seq_DFB_Human1.57265485
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.55377494
41* P300_19829295_ChIP-Seq_ESCs_Human1.54871567
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54087497
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49937011
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48492872
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47208045
46* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46059867
47EWS_26573619_Chip-Seq_HEK293_Human1.45436060
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.44739062
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.44061599
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43519788
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40566493
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38991694
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38653848
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36193859
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.35934149
56RNF2_27304074_Chip-Seq_NSC_Mouse1.35890783
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35009523
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.34270771
59AR_25329375_ChIP-Seq_VCAP_Human1.33978214
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33271483
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.31989435
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.31107316
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30281030
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29972715
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28253248
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.26138445
67VDR_22108803_ChIP-Seq_LS180_Human1.23444453
68STAT3_23295773_ChIP-Seq_U87_Human1.21254311
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21138754
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18661807
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18243270
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17676486
73FUS_26573619_Chip-Seq_HEK293_Human1.15029915
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13411936
75* AR_19668381_ChIP-Seq_PC3_Human1.13193432
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13004207
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.11194905
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.08668712
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.08423598
80JUN_21703547_ChIP-Seq_K562_Human1.08093060
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07551145
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06965884
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.06064692
84* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04496104
85AHR_22903824_ChIP-Seq_MCF-7_Human1.04337234
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03405143
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03278440
88* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03220123
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03032127
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02060656
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.02032462
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.01977580
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01774726
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01005047
95SMAD3_21741376_ChIP-Seq_ESCs_Human1.00250661
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00177842
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99961955
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98785406
99SOX9_26525672_Chip-Seq_HEART_Mouse0.98743228
100* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98601018
101* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98024001
102* TCF4_23295773_ChIP-Seq_U87_Human0.97804285
103* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96939178
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96877292
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.96186920
106TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96073409
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95734782
108TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94646291
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94464143
110* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94240701
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93255842
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93255842
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93042888
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92204831
115TP53_18474530_ChIP-ChIP_U2OS_Human0.92145203
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91853855
117BCAT_22108803_ChIP-Seq_LS180_Human0.91728907
118* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90860861
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89756305
120REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89620721
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.89293571
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.88836702
123ER_23166858_ChIP-Seq_MCF-7_Human0.88529718
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88163165
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87944234
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87857559
127* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87286710
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86873301
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86344592
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85738691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56634168
2MP0003880_abnormal_central_pattern4.81785779
3MP0003635_abnormal_synaptic_transmissio3.83847668
4MP0004270_analgesia3.33532054
5MP0002063_abnormal_learning/memory/cond3.20470201
6MP0009745_abnormal_behavioral_response3.02868570
7MP0001968_abnormal_touch/_nociception2.97407093
8MP0002064_seizures2.75719675
9MP0002572_abnormal_emotion/affect_behav2.67237776
10MP0002734_abnormal_mechanical_nocicepti2.57210801
11MP0002736_abnormal_nociception_after2.43597858
12MP0006276_abnormal_autonomic_nervous2.37491527
13MP0009046_muscle_twitch2.34743665
14MP0009780_abnormal_chondrocyte_physiolo2.33336238
15MP0002735_abnormal_chemical_nociception2.30972036
16MP0002272_abnormal_nervous_system2.26675697
17MP0005423_abnormal_somatic_nervous2.25200114
18MP0001984_abnormal_olfaction2.19138439
19MP0002822_catalepsy2.16136232
20MP0001486_abnormal_startle_reflex2.15463943
21MP0002733_abnormal_thermal_nociception2.15178080
22MP0003122_maternal_imprinting2.12615470
23MP0001440_abnormal_grooming_behavior2.10933677
24MP0002909_abnormal_adrenal_gland2.09128128
25MP0002184_abnormal_innervation2.07831215
26MP0000778_abnormal_nervous_system2.00107044
27MP0001970_abnormal_pain_threshold1.99151444
28MP0001501_abnormal_sleep_pattern1.98349733
29MP0005645_abnormal_hypothalamus_physiol1.87840704
30MP0003329_amyloid_beta_deposits1.87331765
31MP0002067_abnormal_sensory_capabilities1.83471070
32MP0002557_abnormal_social/conspecific_i1.83038389
33MP0004133_heterotaxia1.82098212
34MP0004858_abnormal_nervous_system1.81996974
35MP0001529_abnormal_vocalization1.81679094
36MP0005646_abnormal_pituitary_gland1.77945930
37MP0010386_abnormal_urinary_bladder1.77235818
38MP0005386_behavior/neurological_phenoty1.69980791
39MP0004924_abnormal_behavior1.69980791
40MP0004811_abnormal_neuron_physiology1.67498699
41MP0000955_abnormal_spinal_cord1.52509897
42MP0001502_abnormal_circadian_rhythm1.51778916
43MP0000013_abnormal_adipose_tissue1.45366181
44MP0002882_abnormal_neuron_morphology1.41963616
45MP0003937_abnormal_limbs/digits/tail_de1.40484671
46MP0003879_abnormal_hair_cell1.38556425
47MP0005248_abnormal_Harderian_gland1.38209460
48MP0001905_abnormal_dopamine_level1.33831726
49MP0003283_abnormal_digestive_organ1.30191961
50MP0008569_lethality_at_weaning1.29086105
51MP0002066_abnormal_motor_capabilities/c1.28362328
52MP0003890_abnormal_embryonic-extraembry1.27516908
53MP0004272_abnormal_basement_membrane1.26982986
54MP0010030_abnormal_orbit_morphology1.21200224
55MP0002638_abnormal_pupillary_reflex1.20104937
56MP0002837_dystrophic_cardiac_calcinosis1.18811899
57MP0003941_abnormal_skin_development1.17539318
58MP0000631_abnormal_neuroendocrine_gland1.17396734
59MP0003942_abnormal_urinary_system1.15788590
60MP0003787_abnormal_imprinting1.14932325
61MP0002938_white_spotting1.14611185
62MP0002233_abnormal_nose_morphology1.13303587
63MP0002152_abnormal_brain_morphology1.12632029
64MP0002102_abnormal_ear_morphology1.11445465
65MP0006072_abnormal_retinal_apoptosis1.06638750
66MP0010234_abnormal_vibrissa_follicle1.06116546
67MP0004885_abnormal_endolymph1.05813295
68MP0000566_synostosis1.04693985
69MP0001188_hyperpigmentation1.04038301
70MP0008877_abnormal_DNA_methylation1.02640790
71MP0003119_abnormal_digestive_system1.00685930
72MP0003633_abnormal_nervous_system1.00636713
73MP0005551_abnormal_eye_electrophysiolog0.98711352
74MP0003755_abnormal_palate_morphology0.98348829
75MP0005394_taste/olfaction_phenotype0.98104323
76MP0005499_abnormal_olfactory_system0.98104323
77MP0002697_abnormal_eye_size0.97970030
78MP0001944_abnormal_pancreas_morphology0.96924034
79MP0000462_abnormal_digestive_system0.96805182
80MP0002160_abnormal_reproductive_system0.95286047
81MP0000537_abnormal_urethra_morphology0.94943925
82MP0002069_abnormal_eating/drinking_beha0.94092492
83MP0004142_abnormal_muscle_tone0.93468239
84MP0002234_abnormal_pharynx_morphology0.92930229
85MP0000751_myopathy0.92118097
86MP0003385_abnormal_body_wall0.89994471
87MP0000049_abnormal_middle_ear0.89296573
88MP0004145_abnormal_muscle_electrophysio0.87693421
89MP0000579_abnormal_nail_morphology0.87086283
90MP0005503_abnormal_tendon_morphology0.87076311
91MP0002752_abnormal_somatic_nervous0.86814296
92MP0003634_abnormal_glial_cell0.86443489
93MP0003631_nervous_system_phenotype0.85951691
94MP0001299_abnormal_eye_distance/0.84257029
95MP0003183_abnormal_peptide_metabolism0.83589676
96MP0000639_abnormal_adrenal_gland0.83397916
97MP0000647_abnormal_sebaceous_gland0.83395298
98MP0008438_abnormal_cutaneous_collagen0.82750413
99MP0002163_abnormal_gland_morphology0.82679760
100MP0005623_abnormal_meninges_morphology0.82486651
101MP0002229_neurodegeneration0.81729338
102MP0002928_abnormal_bile_duct0.80638360
103MP0001293_anophthalmia0.79357365
104MP0001664_abnormal_digestion0.78549835
105MP0002876_abnormal_thyroid_physiology0.78325202
106MP0001963_abnormal_hearing_physiology0.77855252
107MP0005391_vision/eye_phenotype0.77615337
108MP0004085_abnormal_heartbeat0.76798740
109MP0008961_abnormal_basal_metabolism0.76535745
110MP0001286_abnormal_eye_development0.75708167
111MP0004742_abnormal_vestibular_system0.75551612
112MP0005535_abnormal_body_temperature0.74664424
113MP0002653_abnormal_ependyma_morphology0.74657459
114MP0003011_delayed_dark_adaptation0.74340076
115MP0003121_genomic_imprinting0.72062125
116MP0000538_abnormal_urinary_bladder0.71892621
117MP0005379_endocrine/exocrine_gland_phen0.71731208
118MP0002090_abnormal_vision0.71323140
119MP0000604_amyloidosis0.71296187
120MP0004233_abnormal_muscle_weight0.71035730
121MP0003861_abnormal_nervous_system0.68012037
122MP0001177_atelectasis0.67315139
123MP0005187_abnormal_penis_morphology0.65665111
124MP0002751_abnormal_autonomic_nervous0.65475595
125MP0000534_abnormal_ureter_morphology0.64541934
126MP0006292_abnormal_olfactory_placode0.61983603
127MP0008789_abnormal_olfactory_epithelium0.60435831
128MP0005253_abnormal_eye_physiology0.60140421
129MP0000026_abnormal_inner_ear0.59866806
130MP0008872_abnormal_physiological_respon0.59013680
131MP0003123_paternal_imprinting0.58692944
132MP0003632_abnormal_nervous_system0.58454816
133MP0001943_abnormal_respiration0.57809236
134MP0004215_abnormal_myocardial_fiber0.56735276

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.31152690
2Myokymia (HP:0002411)5.56669483
3Visual hallucinations (HP:0002367)4.93944780
4Focal seizures (HP:0007359)4.81033333
5Epileptic encephalopathy (HP:0200134)4.28558170
6Atonic seizures (HP:0010819)4.25197223
7Absence seizures (HP:0002121)3.76800976
8Febrile seizures (HP:0002373)3.64144617
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.46268445
10Supranuclear gaze palsy (HP:0000605)3.43642801
11Generalized tonic-clonic seizures (HP:0002069)3.37821176
12Dialeptic seizures (HP:0011146)3.31746948
13Pancreatic fibrosis (HP:0100732)3.23042914
14Abnormal respiratory epithelium morphology (HP:0012253)3.19685226
15Abnormal respiratory motile cilium morphology (HP:0005938)3.19685226
16Progressive cerebellar ataxia (HP:0002073)3.16396484
17Poor eye contact (HP:0000817)3.03912361
18Amblyopia (HP:0000646)3.01210373
19True hermaphroditism (HP:0010459)2.99396657
20Occipital encephalocele (HP:0002085)2.97279261
21Depression (HP:0000716)2.91288852
22Broad-based gait (HP:0002136)2.90013578
23Limb dystonia (HP:0002451)2.88551387
24Ankle clonus (HP:0011448)2.84062141
25Hyperventilation (HP:0002883)2.81743927
26Congenital malformation of the right heart (HP:0011723)2.81469328
27Double outlet right ventricle (HP:0001719)2.81469328
28Anxiety (HP:0000739)2.78923309
29Cerebral inclusion bodies (HP:0100314)2.77899793
30Action tremor (HP:0002345)2.71166833
31Excessive salivation (HP:0003781)2.70758408
32Drooling (HP:0002307)2.70758408
33Truncal ataxia (HP:0002078)2.70573783
34Epileptiform EEG discharges (HP:0011182)2.70079526
35Gait imbalance (HP:0002141)2.69924705
36Papilledema (HP:0001085)2.66675171
37Nephronophthisis (HP:0000090)2.64084645
38EEG with generalized epileptiform discharges (HP:0011198)2.63305347
39Mutism (HP:0002300)2.61785119
40Neurofibrillary tangles (HP:0002185)2.61620672
41Agitation (HP:0000713)2.60687618
42Molar tooth sign on MRI (HP:0002419)2.60588244
43Abnormality of midbrain morphology (HP:0002418)2.60588244
44Pancreatic cysts (HP:0001737)2.56814783
45Abnormal social behavior (HP:0012433)2.56476177
46Impaired social interactions (HP:0000735)2.56476177
47Abnormal eating behavior (HP:0100738)2.56261541
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55502227
49Pheochromocytoma (HP:0002666)2.54642064
50Impaired vibration sensation in the lower limbs (HP:0002166)2.51615630
51Polyphagia (HP:0002591)2.49420389
52Progressive inability to walk (HP:0002505)2.44584832
53Hypsarrhythmia (HP:0002521)2.43331850
54Failure to thrive in infancy (HP:0001531)2.41487683
55Retinal dysplasia (HP:0007973)2.35727020
56Torticollis (HP:0000473)2.29907739
57Hypoventilation (HP:0002791)2.28812208
58Hemiparesis (HP:0001269)2.28172576
59Hyperinsulinemic hypoglycemia (HP:0000825)2.27892140
60Congenital primary aphakia (HP:0007707)2.24601181
61Neuroendocrine neoplasm (HP:0100634)2.24309878
62Abdominal situs inversus (HP:0003363)2.23535653
63Abnormality of abdominal situs (HP:0011620)2.23535653
64Termporal pattern (HP:0011008)2.21877031
65Insidious onset (HP:0003587)2.21877031
66Medial flaring of the eyebrow (HP:0010747)2.20768041
67Urinary urgency (HP:0000012)2.20659643
68Postaxial hand polydactyly (HP:0001162)2.20078723
69Dysmetria (HP:0001310)2.18201906
70Cystic liver disease (HP:0006706)2.17668546
71Dysdiadochokinesis (HP:0002075)2.17301594
72Megalencephaly (HP:0001355)2.15834115
73Postaxial foot polydactyly (HP:0001830)2.15093644
74Intestinal atresia (HP:0011100)2.14706118
75Inability to walk (HP:0002540)2.13067681
76Urinary bladder sphincter dysfunction (HP:0002839)2.11925544
77Focal dystonia (HP:0004373)2.10489918
78Impaired smooth pursuit (HP:0007772)2.09005863
79Spastic gait (HP:0002064)2.08406294
80Gaze-evoked nystagmus (HP:0000640)2.07700388
81Nephrogenic diabetes insipidus (HP:0009806)2.06685421
82Menstrual irregularities (HP:0000858)2.05270834
83Abnormality of the renal medulla (HP:0100957)2.04972141
84Abnormality of the lower motor neuron (HP:0002366)2.04534648
85Hypoplasia of the brainstem (HP:0002365)2.02489259
86Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02489259
87Poor coordination (HP:0002370)2.02149825
88Absent speech (HP:0001344)2.01749478
89Bradykinesia (HP:0002067)2.01649417
90Postural instability (HP:0002172)2.01167895
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.00636311
92Abnormality of dentin (HP:0010299)1.99842035
93Specific learning disability (HP:0001328)1.99105910
94Hypoglycemic seizures (HP:0002173)1.99096823
95Stereotypic behavior (HP:0000733)1.98671535
96Delusions (HP:0000746)1.96705144
97Labial hypoplasia (HP:0000066)1.96678756
98Type II lissencephaly (HP:0007260)1.96160812
99Lissencephaly (HP:0001339)1.95483183
100Abnormal ciliary motility (HP:0012262)1.95047550
101Sclerocornea (HP:0000647)1.94141636
102Craniofacial dystonia (HP:0012179)1.93799508
103Abnormality of binocular vision (HP:0011514)1.93435948
104Diplopia (HP:0000651)1.93435948
105Amyotrophic lateral sclerosis (HP:0007354)1.93353106
106Lower limb muscle weakness (HP:0007340)1.93210698
107Abnormal respiratory motile cilium physiology (HP:0012261)1.93128374
108Anencephaly (HP:0002323)1.92009518
109Shoulder girdle muscle weakness (HP:0003547)1.90900075
110Vaginal atresia (HP:0000148)1.90819042
111Genital tract atresia (HP:0001827)1.90001107
112Bifid tongue (HP:0010297)1.89178469
113Abnormality of salivation (HP:0100755)1.83886977
114Chronic bronchitis (HP:0004469)1.82864757
115Insomnia (HP:0100785)1.82739268
116Decreased testicular size (HP:0008734)1.81381123
117Hyperthyroidism (HP:0000836)1.81103186
118Scanning speech (HP:0002168)1.81053075
119Hypercortisolism (HP:0001578)1.80748219
120Poor suck (HP:0002033)1.79446538
121Abnormality of the corticospinal tract (HP:0002492)1.78606646
122Gait ataxia (HP:0002066)1.77579629
123Abnormality of calcium-phosphate metabolism (HP:0100530)1.76695452
124Fetal akinesia sequence (HP:0001989)1.76413902
125Hypoplastic female external genitalia (HP:0012815)1.75434923
126Enlarged penis (HP:0000040)1.75426952
127Abnormality of the labia minora (HP:0012880)1.75034478
128Narrow forehead (HP:0000341)1.74799615
129Absent/shortened dynein arms (HP:0200106)1.74324802
130Dynein arm defect of respiratory motile cilia (HP:0012255)1.74324802
131Exotropia (HP:0000577)1.74291172
132Hypoglycemic coma (HP:0001325)1.73647876
133Psychosis (HP:0000709)1.73242726
134Aplasia/Hypoplasia of the lens (HP:0008063)1.73004524
135Broad foot (HP:0001769)1.71938186
136Abnormality of ocular smooth pursuit (HP:0000617)1.71491317
137Rhinitis (HP:0012384)1.71267854
138Preaxial hand polydactyly (HP:0001177)1.67849583
139Chronic hepatic failure (HP:0100626)1.67130577
140Tubular atrophy (HP:0000092)1.65120500
141Micropenis (HP:0000054)1.61886166
142Hepatoblastoma (HP:0002884)1.61299383
143Anophthalmia (HP:0000528)1.61267223
144Delayed gross motor development (HP:0002194)1.61236734
145Cutaneous finger syndactyly (HP:0010554)1.59764006
146Male pseudohermaphroditism (HP:0000037)1.59613171
147Left ventricular hypertrophy (HP:0001712)1.51631767
148Cortical dysplasia (HP:0002539)1.50530719
149Short tibia (HP:0005736)1.50045606
150Congenital hepatic fibrosis (HP:0002612)1.49690669
151Prominent nasal bridge (HP:0000426)1.49614928
152Spastic tetraplegia (HP:0002510)1.49355318
153Abnormal pancreas size (HP:0012094)1.49322998
154Tubulointerstitial nephritis (HP:0001970)1.49127276
155Furrowed tongue (HP:0000221)1.47541180
156Short foot (HP:0001773)1.46232153
157Renal hypoplasia (HP:0000089)1.45418209
158Abnormality of the labia (HP:0000058)1.42741700
159Muscular hypotonia of the trunk (HP:0008936)1.41648197
160Sleep apnea (HP:0010535)1.41475068
161Hand muscle atrophy (HP:0009130)1.41370229
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.40773416
163Buphthalmos (HP:0000557)1.40273302
164Pachygyria (HP:0001302)1.40135157
165Chorioretinal coloboma (HP:0000567)1.39750950
166Aganglionic megacolon (HP:0002251)1.39455110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.38822794
2EPHA44.16137360
3MAP3K93.96230338
4MARK13.42428819
5MINK12.73348192
6MAP3K42.71724613
7MAP3K122.40808243
8MAP2K72.37275143
9KSR12.25150189
10KSR22.22345537
11DAPK22.18621819
12PAK62.13695757
13TRIM282.13577098
14NTRK22.09543916
15CASK2.07297083
16ARAF1.97803454
17FRK1.97713242
18PRKD31.96648644
19NTRK11.87676822
20RIPK41.79023813
21PLK21.76355562
22CSNK1G11.69033111
23EPHA31.67083691
24PNCK1.66387431
25MAP2K41.62706310
26DAPK11.61136835
27MAPK131.59462334
28UHMK11.58434201
29CSNK1A1L1.55972378
30EPHB21.55307965
31DYRK31.51922985
32FGFR21.47557543
33CDK51.46513620
34GRK51.45143243
35SIK31.43371696
36PRPF4B1.37970008
37CAMKK11.37058924
38MAP3K21.32346277
39STK38L1.30889097
40PAK31.21471191
41SIK21.19683967
42PRKCG1.16129453
43BCR1.15779725
44CAMKK21.15023351
45PHKG21.15012708
46PHKG11.15012708
47MAP4K21.06703103
48CAMK2A1.03895515
49MAP3K131.03486804
50TNIK1.01019837
51LATS20.99617186
52BMPR20.98516065
53CDK180.98392521
54WNK30.97775533
55CDK140.96845493
56GRK10.94487683
57FER0.91923878
58STK160.89547082
59CDK150.88801438
60PTK2B0.88295733
61RAF10.88120578
62CSNK1G20.85490521
63CDK190.84560107
64TYRO30.83946075
65RET0.83252513
66CAMK2B0.82237701
67DYRK1A0.82135225
68LATS10.80809128
69PTK20.80604403
70CDK11A0.74568418
71STK380.73416552
72BRAF0.71177573
73BMPR1B0.71131497
74MKNK20.70195649
75AKT30.69427378
76ERBB30.68527592
77DYRK20.67169936
78PRKCE0.65768441
79PLK30.64031680
80MAP2K10.62244826
81NME10.61869075
82CCNB10.61115813
83MET0.60319600
84PRKCH0.59261611
85SCYL20.59151879
86INSRR0.58764768
87MYLK0.57437635
88MOS0.57293683
89SGK4940.57274474
90SGK2230.57274474
91DYRK1B0.57126127
92LIMK10.56664306
93MAP3K10.55741548
94BCKDK0.55682248
95MAPK150.55631400
96FES0.54959594
97STK30.54578968
98RPS6KA40.54391297
99EPHB10.51893147
100SRPK10.51670911
101LMTK20.50970142
102ADRBK20.50704146
103CAMK2D0.50666394
104MKNK10.50664497
105MAP3K60.48003379
106ROCK20.47905503
107ADRBK10.46955759
108OXSR10.46466308
109FGR0.46212589
110MARK20.46041539
111PASK0.45484617
112PRKAA10.45187929
113PLK10.44969700
114SGK10.44932232
115CAMK10.44883959
116CSNK1E0.44073920
117CSNK1A10.43527589
118PRKCZ0.43381776
119PKN20.41913394
120CAMK2G0.41613302
121STK110.41227047
122TSSK60.39566162
123MST40.39365593
124PRKACA0.38792340
125GRK70.38670532
126CSNK1G30.38641520
127STK240.37698634
128AKT20.36655134
129TIE10.36189963
130CAMK1G0.35421973
131TAOK10.34711191
132RPS6KA20.34328868
133PINK10.34121434
134FYN0.33173405
135RPS6KA30.32476595
136DDR20.32313804
137WNK40.32151174
138SGK20.31110746
139TESK10.30395250
140HIPK20.29379046
141DAPK30.29371426
142MAPK100.28585380
143CDC42BPA0.27936838

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42973420
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27919865
3Olfactory transduction_Homo sapiens_hsa047402.78629635
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58458463
5GABAergic synapse_Homo sapiens_hsa047272.56063675
6Circadian entrainment_Homo sapiens_hsa047132.53068347
7Long-term potentiation_Homo sapiens_hsa047202.45848184
8Amphetamine addiction_Homo sapiens_hsa050312.41983595
9Morphine addiction_Homo sapiens_hsa050322.41085774
10Protein export_Homo sapiens_hsa030602.30922629
11Glutamatergic synapse_Homo sapiens_hsa047242.28629985
12Insulin secretion_Homo sapiens_hsa049112.23753877
13Dopaminergic synapse_Homo sapiens_hsa047282.23386296
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20009458
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02746182
16Collecting duct acid secretion_Homo sapiens_hsa049661.95739760
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91591286
18Taste transduction_Homo sapiens_hsa047421.91501560
19Salivary secretion_Homo sapiens_hsa049701.89028329
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87717078
21Steroid biosynthesis_Homo sapiens_hsa001001.86251599
22Serotonergic synapse_Homo sapiens_hsa047261.85622417
23Cholinergic synapse_Homo sapiens_hsa047251.85442309
24Cocaine addiction_Homo sapiens_hsa050301.82915430
25Gastric acid secretion_Homo sapiens_hsa049711.72208686
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71992299
27Renin secretion_Homo sapiens_hsa049241.69027287
28Vibrio cholerae infection_Homo sapiens_hsa051101.68073478
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64433671
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53960836
31Oxytocin signaling pathway_Homo sapiens_hsa049211.52419584
32Long-term depression_Homo sapiens_hsa047301.51830080
33Folate biosynthesis_Homo sapiens_hsa007901.49507771
34Gap junction_Homo sapiens_hsa045401.40493978
35Calcium signaling pathway_Homo sapiens_hsa040201.40383863
36GnRH signaling pathway_Homo sapiens_hsa049121.39938153
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36448497
38Butanoate metabolism_Homo sapiens_hsa006501.33832563
39Hippo signaling pathway_Homo sapiens_hsa043901.25354342
40Axon guidance_Homo sapiens_hsa043601.23150667
41Vitamin B6 metabolism_Homo sapiens_hsa007501.21360194
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20512376
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20166411
44Basal cell carcinoma_Homo sapiens_hsa052171.17884838
45Estrogen signaling pathway_Homo sapiens_hsa049151.17870612
46Cardiac muscle contraction_Homo sapiens_hsa042601.14554556
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13354900
48cAMP signaling pathway_Homo sapiens_hsa040241.12983028
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10171087
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09038423
51Melanogenesis_Homo sapiens_hsa049161.08256393
52Fatty acid elongation_Homo sapiens_hsa000621.02818003
53Type II diabetes mellitus_Homo sapiens_hsa049301.01843765
54Phototransduction_Homo sapiens_hsa047441.01425702
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99007023
56Tight junction_Homo sapiens_hsa045300.98908699
57Glioma_Homo sapiens_hsa052140.98392180
58Oocyte meiosis_Homo sapiens_hsa041140.97103360
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95250344
60Propanoate metabolism_Homo sapiens_hsa006400.94358010
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93351967
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92266825
63ErbB signaling pathway_Homo sapiens_hsa040120.91041751
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.90718172
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89977996
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89633609
67Oxidative phosphorylation_Homo sapiens_hsa001900.89562824
68Thyroid hormone synthesis_Homo sapiens_hsa049180.84473879
69Pancreatic secretion_Homo sapiens_hsa049720.84457424
70Alzheimers disease_Homo sapiens_hsa050100.84025592
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80329015
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73199624
73Parkinsons disease_Homo sapiens_hsa050120.72300862
74Alcoholism_Homo sapiens_hsa050340.71367466
75Dilated cardiomyopathy_Homo sapiens_hsa054140.71087059
76Type I diabetes mellitus_Homo sapiens_hsa049400.70161669
77Sulfur metabolism_Homo sapiens_hsa009200.69446145
78Selenocompound metabolism_Homo sapiens_hsa004500.69292810
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69141448
80ECM-receptor interaction_Homo sapiens_hsa045120.68437529
81beta-Alanine metabolism_Homo sapiens_hsa004100.68339239
82Sphingolipid metabolism_Homo sapiens_hsa006000.67702152
83Dorso-ventral axis formation_Homo sapiens_hsa043200.67172531
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.66688683
85Glucagon signaling pathway_Homo sapiens_hsa049220.65867343
86* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63329109
87Prion diseases_Homo sapiens_hsa050200.63307881
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.62527725
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61827054
90VEGF signaling pathway_Homo sapiens_hsa043700.61070086
91Choline metabolism in cancer_Homo sapiens_hsa052310.60971206
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60617057
93MAPK signaling pathway_Homo sapiens_hsa040100.60272715
94Protein digestion and absorption_Homo sapiens_hsa049740.59394591
95Adherens junction_Homo sapiens_hsa045200.58579219
96Ras signaling pathway_Homo sapiens_hsa040140.58507019
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58248630
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58095482
99Fatty acid metabolism_Homo sapiens_hsa012120.56820100
100TGF-beta signaling pathway_Homo sapiens_hsa043500.55744235
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55533013
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55133317
103Glutathione metabolism_Homo sapiens_hsa004800.54914509
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54219344
105Circadian rhythm_Homo sapiens_hsa047100.54076642
106Peroxisome_Homo sapiens_hsa041460.54063571
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53878581
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52970433
109Wnt signaling pathway_Homo sapiens_hsa043100.52827326
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52331937
111Rap1 signaling pathway_Homo sapiens_hsa040150.51805844
112Arginine and proline metabolism_Homo sapiens_hsa003300.51702986
113Regulation of autophagy_Homo sapiens_hsa041400.51612958
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51319950
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51212140
116Basal transcription factors_Homo sapiens_hsa030220.50824627
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50338887
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49421993
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48703524
120Endometrial cancer_Homo sapiens_hsa052130.48690127
121Huntingtons disease_Homo sapiens_hsa050160.48568642
122Renal cell carcinoma_Homo sapiens_hsa052110.48402761
123* Metabolic pathways_Homo sapiens_hsa011000.48343307
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46870524
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.46639541
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45957991
127Pyruvate metabolism_Homo sapiens_hsa006200.44515959
128AMPK signaling pathway_Homo sapiens_hsa041520.44472579
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.44235846
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43519671
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43074306
132Rheumatoid arthritis_Homo sapiens_hsa053230.42000595
133Phagosome_Homo sapiens_hsa041450.41864026
134Ovarian steroidogenesis_Homo sapiens_hsa049130.41802151
135Endocytosis_Homo sapiens_hsa041440.41687295
136Colorectal cancer_Homo sapiens_hsa052100.40945771
137mTOR signaling pathway_Homo sapiens_hsa041500.38150056
138Inositol phosphate metabolism_Homo sapiens_hsa005620.37190687
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37053097
140Insulin signaling pathway_Homo sapiens_hsa049100.36271190
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33948223
142Hedgehog signaling pathway_Homo sapiens_hsa043400.31184737
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30977304
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30110935
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26302609

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