TUT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)4.66687898
2maturation of SSU-rRNA (GO:0030490)4.53156412
3proline biosynthetic process (GO:0006561)4.47635390
4nucleobase biosynthetic process (GO:0046112)4.46687156
5ribosomal small subunit assembly (GO:0000028)4.46357752
6DNA deamination (GO:0045006)4.28270220
7DNA unwinding involved in DNA replication (GO:0006268)4.19203872
8folic acid-containing compound biosynthetic process (GO:0009396)4.17574800
9IMP biosynthetic process (GO:0006188)4.13900207
10purine nucleobase biosynthetic process (GO:0009113)4.08338380
11DNA strand elongation involved in DNA replication (GO:0006271)4.05839684
12peptidyl-arginine omega-N-methylation (GO:0035247)4.05178164
13DNA replication initiation (GO:0006270)4.02730456
14mitotic nuclear envelope disassembly (GO:0007077)4.01149942
15ribosome biogenesis (GO:0042254)3.95214321
16protein localization to kinetochore (GO:0034501)3.92914181
17formation of translation preinitiation complex (GO:0001731)3.92665443
18nuclear pore organization (GO:0006999)3.89353018
19DNA strand elongation (GO:0022616)3.86507097
20DNA replication checkpoint (GO:0000076)3.83780552
21telomere maintenance via semi-conservative replication (GO:0032201)3.78284003
22nuclear pore complex assembly (GO:0051292)3.75597670
23IMP metabolic process (GO:0046040)3.67674785
24membrane disassembly (GO:0030397)3.67610124
25nuclear envelope disassembly (GO:0051081)3.67610124
26proline metabolic process (GO:0006560)3.64125037
27ribosome assembly (GO:0042255)3.57311694
28ribonucleoprotein complex biogenesis (GO:0022613)3.55985537
29protein localization to chromosome, centromeric region (GO:0071459)3.53602906
30regulation of chromatin binding (GO:0035561)3.52993635
31DNA replication-dependent nucleosome assembly (GO:0006335)3.51345570
32DNA replication-dependent nucleosome organization (GO:0034723)3.51345570
33pentose metabolic process (GO:0019321)3.49556605
34N-acetylneuraminate metabolic process (GO:0006054)3.47980070
35activation of Rac GTPase activity (GO:0032863)3.46359434
36peptidyl-histidine modification (GO:0018202)3.45751488
37negative regulation of DNA-templated transcription, elongation (GO:0032785)3.43690686
38mitotic metaphase plate congression (GO:0007080)3.41144405
39serine family amino acid biosynthetic process (GO:0009070)3.39001691
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.38445786
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.38445786
42viral transcription (GO:0019083)3.37021628
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.34022468
44translational termination (GO:0006415)3.30726128
45regulation of mammary gland epithelial cell proliferation (GO:0033599)3.29892250
46telomere maintenance via recombination (GO:0000722)3.26732326
47ribosomal large subunit biogenesis (GO:0042273)3.26603060
48peptidyl-arginine methylation (GO:0018216)3.25630496
49peptidyl-arginine N-methylation (GO:0035246)3.25630496
50rRNA processing (GO:0006364)3.24694095
51DNA duplex unwinding (GO:0032508)3.24013862
52translational elongation (GO:0006414)3.23015664
53DNA geometric change (GO:0032392)3.22832845
54cellular response to virus (GO:0098586)3.20906145
55translational initiation (GO:0006413)3.16956098
56DNA topological change (GO:0006265)3.15846235
57spliceosomal snRNP assembly (GO:0000387)3.15590786
58ribosomal small subunit biogenesis (GO:0042274)3.14305289
59rRNA metabolic process (GO:0016072)3.14196712
60mitotic sister chromatid segregation (GO:0000070)3.13721086
61histone arginine methylation (GO:0034969)3.12602318
62pentose-phosphate shunt (GO:0006098)3.10058848
63telomere maintenance via telomere lengthening (GO:0010833)3.09780508
64energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07475003
65ATP synthesis coupled proton transport (GO:0015986)3.07475003
66mitotic chromosome condensation (GO:0007076)3.07315036
673-UTR-mediated mRNA stabilization (GO:0070935)3.05876326
68mitotic recombination (GO:0006312)3.05605556
69viral mRNA export from host cell nucleus (GO:0046784)3.05048076
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03879078
71tRNA modification (GO:0006400)3.02025987
72negative regulation of RNA splicing (GO:0033119)2.99289979
73modulation by virus of host process (GO:0019054)2.97845068
74histone H2A acetylation (GO:0043968)2.97011560
75tRNA methylation (GO:0030488)2.96033176
76regulation of histone H3-K9 methylation (GO:0051570)2.94176144
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93493021
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91985879
79nuclear envelope organization (GO:0006998)2.91775001
80peptidyl-lysine dimethylation (GO:0018027)2.91372385
81GDP-mannose metabolic process (GO:0019673)2.91372026
82chromatin remodeling at centromere (GO:0031055)2.91310613
83metaphase plate congression (GO:0051310)2.91056679
84ncRNA 3-end processing (GO:0043628)2.91046729
85pore complex assembly (GO:0046931)2.89862785
86regulation of translational fidelity (GO:0006450)2.88512597
87negative regulation of erythrocyte differentiation (GO:0045647)2.87917802
88heterochromatin organization (GO:0070828)2.87055654
89folic acid metabolic process (GO:0046655)2.86894759
90Golgi transport vesicle coating (GO:0048200)2.86576460
91COPI coating of Golgi vesicle (GO:0048205)2.86576460
92sister chromatid segregation (GO:0000819)2.85656762
93cellular response to interleukin-4 (GO:0071353)2.85449972
94regulation of spindle organization (GO:0090224)2.85054907
95NADPH regeneration (GO:0006740)2.84315254
96viral life cycle (GO:0019058)2.84115965
97nucleosome disassembly (GO:0006337)2.83650491
98protein-DNA complex disassembly (GO:0032986)2.83650491
99spliceosomal tri-snRNP complex assembly (GO:0000244)2.82724512
100pseudouridine synthesis (GO:0001522)2.82281705
101DNA conformation change (GO:0071103)2.82240567
102mitotic nuclear envelope reassembly (GO:0007084)2.82139491
103nuclear envelope reassembly (GO:0031468)2.82139491
104pteridine-containing compound biosynthetic process (GO:0042559)2.81221786
105negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81109138
106apoptotic process involved in morphogenesis (GO:0060561)2.80659968
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.80314985
108protein targeting to ER (GO:0045047)2.80234316
109cotranslational protein targeting to membrane (GO:0006613)2.79653121
110RNA splicing, via transesterification reactions (GO:0000375)2.79415463
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.79243885
112mRNA splicing, via spliceosome (GO:0000398)2.79243885
113histone H4 deacetylation (GO:0070933)2.79083412
114mitotic G1/S transition checkpoint (GO:0044819)2.78469364
115rRNA modification (GO:0000154)2.78228178
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.78208598
117protein complex disassembly (GO:0043241)2.78114845
118dosage compensation (GO:0007549)2.77933808
119postreplication repair (GO:0006301)2.77597900
120* snRNA metabolic process (GO:0016073)2.77329288
121translesion synthesis (GO:0019985)2.77074212
122* snRNA processing (GO:0016180)2.77017476
123maturation of 5.8S rRNA (GO:0000460)2.76389366
124CENP-A containing nucleosome assembly (GO:0034080)2.75972906
125negative regulation of histone methylation (GO:0031061)2.75290367
126tRNA aminoacylation for protein translation (GO:0006418)2.72716215
127chromosome condensation (GO:0030261)2.72556611
128spliceosomal complex assembly (GO:0000245)2.72002866
129regulation of posttranscriptional gene silencing (GO:0060147)2.71841739
130regulation of gene silencing by miRNA (GO:0060964)2.71841739
131regulation of gene silencing by RNA (GO:0060966)2.71841739
132DNA replication-independent nucleosome assembly (GO:0006336)2.71241209
133DNA replication-independent nucleosome organization (GO:0034724)2.71241209
134negative regulation of mRNA processing (GO:0050686)2.70713126
135intracellular estrogen receptor signaling pathway (GO:0030520)2.70311202
136RNA export from nucleus (GO:0006405)2.69959841
1372-oxoglutarate metabolic process (GO:0006103)2.69944987
138transcription from mitochondrial promoter (GO:0006390)2.69154343
139negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68619962
140negative regulation of chromosome segregation (GO:0051985)2.68394343
141attachment of spindle microtubules to kinetochore (GO:0008608)2.66490151
142mRNA transport (GO:0051028)2.66300113
143kinetochore organization (GO:0051383)2.65978942
144termination of RNA polymerase II transcription (GO:0006369)2.65529837
145mRNA export from nucleus (GO:0006406)2.64975858
146cellular protein complex disassembly (GO:0043624)2.64788231
147establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63459465
148regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63097599
149negative regulation of phagocytosis (GO:0050765)2.62064571
150positive regulation of receptor biosynthetic process (GO:0010870)2.61740507
151modulation by symbiont of host cellular process (GO:0044068)2.61527508
152protein insertion into membrane (GO:0051205)2.60859414
153glucose catabolic process (GO:0006007)2.60211149
154UV protection (GO:0009650)2.59716333
155biotin metabolic process (GO:0006768)2.58610489
156glucose 6-phosphate metabolic process (GO:0051156)2.58205899
157mitochondrial DNA metabolic process (GO:0032042)2.57688929
158negative regulation of cell size (GO:0045792)2.57245099
159positive regulation of histone deacetylation (GO:0031065)2.56572235
160macromolecular complex disassembly (GO:0032984)2.56317186
161mannose metabolic process (GO:0006013)2.54366897
162mitochondrial fusion (GO:0008053)2.50745316
163response to interleukin-4 (GO:0070670)2.50652948
164mitochondrial RNA metabolic process (GO:0000959)2.45061559
165negative regulation of telomerase activity (GO:0051974)2.44798386
166mitotic G1 DNA damage checkpoint (GO:0031571)2.44231387
167negative regulation of viral release from host cell (GO:1902187)2.42881158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36161824
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.96209818
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67188974
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.16990453
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93493094
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82663319
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68548142
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68077498
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62402912
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57649001
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.53149379
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50225814
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.49475335
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47127405
15* MYC_22102868_ChIP-Seq_BL_Human2.40974265
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34514211
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.30816862
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30487903
19* XRN2_22483619_ChIP-Seq_HELA_Human2.24547251
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12381027
21LXR_22292898_ChIP-Seq_THP-1_Human2.11474975
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.07842075
23* VDR_23849224_ChIP-Seq_CD4+_Human2.01748411
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96803872
25* FOXP3_21729870_ChIP-Seq_TREG_Human1.88289359
26* GABP_19822575_ChIP-Seq_HepG2_Human1.87897773
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87695626
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86638401
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.82654383
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82320666
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82274679
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78882188
33* P68_20966046_ChIP-Seq_HELA_Human1.78615903
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78412222
35* DCP1A_22483619_ChIP-Seq_HELA_Human1.77694836
36* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76336676
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75500546
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.74397137
39* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73092506
40CIITA_25753668_ChIP-Seq_RAJI_Human1.71733861
41* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69939171
42AR_21909140_ChIP-Seq_LNCAP_Human1.65632360
43* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63694478
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61739426
45ZNF263_19887448_ChIP-Seq_K562_Human1.61134543
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60392946
47RACK7_27058665_Chip-Seq_MCF-7_Human1.59585332
48KDM5A_27292631_Chip-Seq_BREAST_Human1.55855578
49* TTF2_22483619_ChIP-Seq_HELA_Human1.54937893
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.54772535
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54717678
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53452355
53* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51778845
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.50622514
55* MAF_26560356_Chip-Seq_TH2_Human1.49324456
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48555042
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48136233
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47389125
59VDR_21846776_ChIP-Seq_THP-1_Human1.46931907
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43573836
61KDM2B_26808549_Chip-Seq_DND41_Human1.40905280
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40718523
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40652732
64* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40533694
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.40448024
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39920937
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38895369
68* BCL6_27268052_Chip-Seq_Bcells_Human1.38015992
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.36422334
70* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35952644
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35302842
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34879615
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34252459
74* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32775031
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32333232
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31526810
77* BCOR_27268052_Chip-Seq_Bcells_Human1.31233042
78TFEB_21752829_ChIP-Seq_HELA_Human1.30357834
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29715304
80ELK1_19687146_ChIP-ChIP_HELA_Human1.29606174
81* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29251642
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.28784783
83NCOR1_26117541_ChIP-Seq_K562_Human1.28337994
84* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28036536
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26850245
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26694929
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26587305
88* FOXP1_21924763_ChIP-Seq_HESCs_Human1.25702823
89* SRF_21415370_ChIP-Seq_HL-1_Mouse1.25396121
90VDR_24763502_ChIP-Seq_THP-1_Human1.24995200
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23593479
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23049728
93SMC4_20622854_ChIP-Seq_HELA_Human1.22999149
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22904677
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22388385
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.22128706
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22108167
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21282285
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18820355
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16675357
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.15650481
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15492475
103TP63_19390658_ChIP-ChIP_HaCaT_Human1.14699799
104* PHF8_20622854_ChIP-Seq_HELA_Human1.13972709
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13736283
106* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13353808
107E2F1_20622854_ChIP-Seq_HELA_Human1.10475778
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09125630
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08911829
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.08859219
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07815222
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07310910
113CREB1_26743006_Chip-Seq_LNCaP_Human1.06963385
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06920565
115* CTCF_21964334_Chip-Seq_Bcells_Human1.06672027
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06016609
117RARA_24833708_ChIP-Seq_LIVER_Mouse1.05552695
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04314744
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03628362
120* SPI1_23547873_ChIP-Seq_NB4_Human1.02984817
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02581663
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99988876
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99613374
124* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97273582
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96979364
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95592274
127UTX_26944678_Chip-Seq_JUKART_Human0.94911653
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92528692
129SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90468375
130* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90443884
131* MAF_26560356_Chip-Seq_TH1_Human0.89952738
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88711170
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88295335
134MYB_26560356_Chip-Seq_TH1_Human0.87475048
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86061077
136TCF7_22412390_ChIP-Seq_EML_Mouse0.85856519
137NANOG_21062744_ChIP-ChIP_HESCs_Human0.84633765
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83894228
139* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83379258
140ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82636350
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82180918
142MYB_26560356_Chip-Seq_TH2_Human0.81332115
143RUNX1_22412390_ChIP-Seq_EML_Mouse0.81057950
144CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80983193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.71522777
2MP0003111_abnormal_nucleus_morphology4.10794154
3MP0010094_abnormal_chromosome_stability4.04644817
4MP0004957_abnormal_blastocyst_morpholog3.98545014
5MP0008057_abnormal_DNA_replication3.78300025
6MP0003077_abnormal_cell_cycle3.58576218
7MP0005451_abnormal_body_composition3.44051213
8MP0005058_abnormal_lysosome_morphology3.21425120
9MP0008058_abnormal_DNA_repair2.93014931
10MP0002396_abnormal_hematopoietic_system2.64523102
11MP0008007_abnormal_cellular_replicative2.58330114
12MP0001730_embryonic_growth_arrest2.41833087
13MP0010352_gastrointestinal_tract_polyps2.39100005
14MP0004858_abnormal_nervous_system2.22212259
15MP0002254_reproductive_system_inflammat2.13706305
16MP0004233_abnormal_muscle_weight2.12912191
17MP0000350_abnormal_cell_proliferation2.11989339
18MP0003786_premature_aging2.05030349
19MP0010307_abnormal_tumor_latency2.04793676
20MP0008877_abnormal_DNA_methylation2.00606810
21MP0003763_abnormal_thymus_physiology1.99168736
22MP0008932_abnormal_embryonic_tissue1.91592290
23MP0004808_abnormal_hematopoietic_stem1.90338536
24MP0008260_abnormal_autophagy1.88829077
25MP0000490_abnormal_crypts_of1.86507853
26MP0009333_abnormal_splenocyte_physiolog1.84689220
27MP0003123_paternal_imprinting1.79851691
28MP0001672_abnormal_embryogenesis/_devel1.73612478
29MP0005380_embryogenesis_phenotype1.73612478
30MP0009840_abnormal_foam_cell1.69287541
31MP0001697_abnormal_embryo_size1.66114347
32MP0005083_abnormal_biliary_tract1.63567366
33MP0001545_abnormal_hematopoietic_system1.62250962
34MP0005397_hematopoietic_system_phenotyp1.62250962
35MP0002080_prenatal_lethality1.61562241
36MP0003984_embryonic_growth_retardation1.61355006
37MP0002019_abnormal_tumor_incidence1.57998147
38MP0002088_abnormal_embryonic_growth/wei1.57795997
39MP0002398_abnormal_bone_marrow1.57553091
40MP0000313_abnormal_cell_death1.50921364
41MP0005076_abnormal_cell_differentiation1.50736427
42MP0004185_abnormal_adipocyte_glucose1.50072479
43MP0000689_abnormal_spleen_morphology1.49796706
44MP0000703_abnormal_thymus_morphology1.48544895
45MP0002653_abnormal_ependyma_morphology1.46452593
46MP0002722_abnormal_immune_system1.45559219
47MP0003806_abnormal_nucleotide_metabolis1.44639368
48MP0005501_abnormal_skin_physiology1.41120478
49MP0002086_abnormal_extraembryonic_tissu1.40509322
50MP0002085_abnormal_embryonic_tissue1.39763943
51MP0002084_abnormal_developmental_patter1.36288148
52MP0000678_abnormal_parathyroid_gland1.35659004
53MP0003303_peritoneal_inflammation1.34448598
54MP0002210_abnormal_sex_determination1.33124386
55MP0004197_abnormal_fetal_growth/weight/1.31418528
56MP0004381_abnormal_hair_follicle1.31082521
57MP0003172_abnormal_lysosome_physiology1.30706014
58MP0003646_muscle_fatigue1.30532916
59MP0001929_abnormal_gametogenesis1.26565738
60MP0002132_abnormal_respiratory_system1.25501114
61MP0005360_urolithiasis1.22917926
62MP0002249_abnormal_larynx_morphology1.20897338
63MP0002429_abnormal_blood_cell1.20059360
64MP0000750_abnormal_muscle_regeneration1.19814857
65MP0001145_abnormal_male_reproductive1.18123705
66MP0001661_extended_life_span1.15142609
67MP0006035_abnormal_mitochondrial_morpho1.14510154
68MP0010030_abnormal_orbit_morphology1.14002951
69MP0006054_spinal_hemorrhage1.11850010
70MP0000716_abnormal_immune_system1.11671836
71MP0009278_abnormal_bone_marrow1.11157176
72MP0001800_abnormal_humoral_immune1.10303176
73MP0003191_abnormal_cellular_cholesterol1.07735548
74MP0003890_abnormal_embryonic-extraembry1.07226485
75MP0000685_abnormal_immune_system1.06753813
76MP0003718_maternal_effect1.06606965
77MP0001293_anophthalmia1.06105546
78MP0003705_abnormal_hypodermis_morpholog1.04483270
79MP0000858_altered_metastatic_potential1.01882211
80MP0005666_abnormal_adipose_tissue1.00637320
81MP0004264_abnormal_extraembryonic_tissu0.99713290
82MP0000653_abnormal_sex_gland0.98228276
83MP0008875_abnormal_xenobiotic_pharmacok0.95990307
84MP0000358_abnormal_cell_content/0.94325425
85MP0001849_ear_inflammation0.93646222
86MP0002089_abnormal_postnatal_growth/wei0.93527984
87MP0009672_abnormal_birth_weight0.93054298
88MP0009053_abnormal_anal_canal0.92451462
89MP0002420_abnormal_adaptive_immunity0.90744605
90MP0001915_intracranial_hemorrhage0.90134281
91MP0005171_absent_coat_pigmentation0.89465049
92MP0000609_abnormal_liver_physiology0.89373778
93MP0002452_abnormal_antigen_presenting0.88765272
94MP0001819_abnormal_immune_cell0.88045170
95MP0005023_abnormal_wound_healing0.87668958
96MP0002405_respiratory_system_inflammati0.85475055
97MP0002723_abnormal_immune_serum0.84909861
98MP0000477_abnormal_intestine_morphology0.84849382
99MP0008995_early_reproductive_senescence0.84520442
100MP0005075_abnormal_melanosome_morpholog0.84492317
101MP0005025_abnormal_response_to0.83702473
102MP0005365_abnormal_bile_salt0.83546777
103MP0003121_genomic_imprinting0.83063005
104MP0005671_abnormal_response_to0.82977084
105MP0001873_stomach_inflammation0.82197223
106MP0000747_muscle_weakness0.81478161
107MP0005384_cellular_phenotype0.81095397
108MP0002139_abnormal_hepatobiliary_system0.81076912
109MP0003453_abnormal_keratinocyte_physiol0.80812252
110MP0005621_abnormal_cell_physiology0.79825239
111MP0004133_heterotaxia0.78299713
112MP0001835_abnormal_antigen_presentation0.77536065
113MP0010155_abnormal_intestine_physiology0.77133239
114MP0001119_abnormal_female_reproductive0.76954991
115MP0002970_abnormal_white_adipose0.76940899
116MP0003119_abnormal_digestive_system0.76405622
117MP0005410_abnormal_fertilization0.75785080
118MP0000598_abnormal_liver_morphology0.75759918
119MP0004947_skin_inflammation0.74052072
120MP0002877_abnormal_melanocyte_morpholog0.72744017
121MP0002092_abnormal_eye_morphology0.72266008
122MP0000751_myopathy0.72249001
123MP0003878_abnormal_ear_physiology0.71824395
124MP0005377_hearing/vestibular/ear_phenot0.71824395
125MP0005375_adipose_tissue_phenotype0.71739410
126MP0003315_abnormal_perineum_morphology0.70844614
127MP0000465_gastrointestinal_hemorrhage0.70534191
128MP0002111_abnormal_tail_morphology0.70403942
129MP0006292_abnormal_olfactory_placode0.70005303
130MP0003698_abnormal_male_reproductive0.69619521
131MP0009931_abnormal_skin_appearance0.69325340
132MP0003186_abnormal_redox_activity0.69184360
133MP0001764_abnormal_homeostasis0.69009406
134MP0005330_cardiomyopathy0.68760561
135MP0002160_abnormal_reproductive_system0.68380182
136MP0000003_abnormal_adipose_tissue0.68118050
137MP0003566_abnormal_cell_adhesion0.67817970
138MP0003436_decreased_susceptibility_to0.67582470
139MP0005266_abnormal_metabolism0.67466500
140MP0003943_abnormal_hepatobiliary_system0.66887069
141MP0003567_abnormal_fetal_cardiomyocyte0.65590204
142MP0003221_abnormal_cardiomyocyte_apopto0.64247488
143MP0002161_abnormal_fertility/fecundity0.62487125
144MP0003866_abnormal_defecation0.61694418
145MP0006036_abnormal_mitochondrial_physio0.61632239

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)4.19101001
2Degeneration of anterior horn cells (HP:0002398)4.19101001
3Reticulocytopenia (HP:0001896)4.03546320
4Progressive muscle weakness (HP:0003323)4.00998161
5Hyperacusis (HP:0010780)3.75405846
6Ragged-red muscle fibers (HP:0003200)3.70897903
7Ependymoma (HP:0002888)3.58758658
8Birth length less than 3rd percentile (HP:0003561)3.50908298
9Hemorrhage of the eye (HP:0011885)3.48351357
10Aplastic anemia (HP:0001915)3.37263571
11Testicular atrophy (HP:0000029)3.37168355
12Abnormality of cells of the erythroid lineage (HP:0012130)3.30474335
13Abnormal number of erythroid precursors (HP:0012131)3.29961939
14Cholecystitis (HP:0001082)3.27746407
15Abnormal gallbladder physiology (HP:0012438)3.27746407
16Reticulocytosis (HP:0001923)3.23653570
17Thrombocytosis (HP:0001894)3.16362199
1811 pairs of ribs (HP:0000878)3.07927454
19Carpal bone hypoplasia (HP:0001498)3.03999804
20Broad distal phalanx of finger (HP:0009836)3.00542854
21Rhabdomyosarcoma (HP:0002859)2.94177219
22Selective tooth agenesis (HP:0001592)2.90907371
23Medulloblastoma (HP:0002885)2.90469115
24Myelodysplasia (HP:0002863)2.89164334
25Urethral obstruction (HP:0000796)2.88857871
26Microvesicular hepatic steatosis (HP:0001414)2.87928112
27Absent thumb (HP:0009777)2.85925348
28Chromsome breakage (HP:0040012)2.80220309
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74474876
30Oral leukoplakia (HP:0002745)2.74430413
31Truncus arteriosus (HP:0001660)2.70068684
32Colon cancer (HP:0003003)2.69601801
33Basal cell carcinoma (HP:0002671)2.66716145
34Breast hypoplasia (HP:0003187)2.66248993
35Progressive external ophthalmoplegia (HP:0000590)2.64342155
36Increased serum ferritin (HP:0003281)2.62551798
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62444408
38Impulsivity (HP:0100710)2.61017406
39IgM deficiency (HP:0002850)2.60950970
40Agnosia (HP:0010524)2.59991771
41Abnormality of glycolysis (HP:0004366)2.58855345
42Patellar aplasia (HP:0006443)2.52042899
43Seborrheic dermatitis (HP:0001051)2.49742499
44Abnormality of chromosome stability (HP:0003220)2.49415474
45Recurrent bronchitis (HP:0002837)2.46418571
46Meckel diverticulum (HP:0002245)2.42135992
47Annular pancreas (HP:0001734)2.41708005
48Cholelithiasis (HP:0001081)2.40777210
49J-shaped sella turcica (HP:0002680)2.39885092
50Insomnia (HP:0100785)2.39070510
51Deep venous thrombosis (HP:0002625)2.38942433
52Abnormality of the ileum (HP:0001549)2.38352070
53Hypertensive crisis (HP:0100735)2.37892376
54Abnormality of the preputium (HP:0100587)2.37420644
55Abnormality of pyrimidine metabolism (HP:0004353)2.37199212
56Spinal muscular atrophy (HP:0007269)2.37162425
57Abnormality of the aortic arch (HP:0012303)2.36536450
58Multiple enchondromatosis (HP:0005701)2.35458857
59Cerebral hypomyelination (HP:0006808)2.34350178
60Aplasia/Hypoplasia of the patella (HP:0006498)2.31129732
61Cutaneous melanoma (HP:0012056)2.30135715
62Pallor (HP:0000980)2.29573423
63Myopathic facies (HP:0002058)2.28263412
64Long palpebral fissure (HP:0000637)2.27522196
65Neoplasm of striated muscle (HP:0009728)2.27127544
66Neoplasm of the pancreas (HP:0002894)2.25362930
67Rough bone trabeculation (HP:0100670)2.24900120
68Renovascular hypertension (HP:0100817)2.23571422
69Astrocytoma (HP:0009592)2.23506534
70Abnormality of the astrocytes (HP:0100707)2.23506534
71Colitis (HP:0002583)2.23222869
72Missing ribs (HP:0000921)2.22258550
73Increased serum pyruvate (HP:0003542)2.21892720
74Macrocytic anemia (HP:0001972)2.20346102
75Trismus (HP:0000211)2.20309951
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20205979
77Nasal polyposis (HP:0100582)2.20178542
78Amaurosis fugax (HP:0100576)2.19568090
79Bone marrow hypocellularity (HP:0005528)2.15918800
80Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15533776
81Abnormality of T cell physiology (HP:0011840)2.14205323
82Atrophy/Degeneration involving motor neurons (HP:0007373)2.13112434
83Cafe-au-lait spot (HP:0000957)2.12955365
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.12550431
85Lymphoma (HP:0002665)2.12082116
86Tongue fasciculations (HP:0001308)2.12029568
87Slow saccadic eye movements (HP:0000514)2.11853707
88Thoracic kyphosis (HP:0002942)2.11766125
89Flattened epiphyses (HP:0003071)2.10645984
90Abnormality of alanine metabolism (HP:0010916)2.10224790
91Hyperalaninemia (HP:0003348)2.10224790
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10224790
93Abnormality of T cells (HP:0002843)2.09530803
94Abnormal trabecular bone morphology (HP:0100671)2.08307309
95Back pain (HP:0003418)2.06347168
96Glioma (HP:0009733)2.06201634
97Squamous cell carcinoma (HP:0002860)2.05769152
98Poikiloderma (HP:0001029)2.05435815
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04348282
100Microretrognathia (HP:0000308)2.02342703
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02115982
102Pancytopenia (HP:0001876)2.01479711
103Brushfield spots (HP:0001088)2.00140140
104Self-mutilation (HP:0000742)2.00044015
105Thin bony cortex (HP:0002753)1.99825749
106Pseudobulbar signs (HP:0002200)1.99747162
107Premature ovarian failure (HP:0008209)1.99170341
108Abnormality of the nasal mucosa (HP:0000433)1.98924560
109Abnormality of the gallbladder (HP:0005264)1.98223088
110Abnormality of the thoracic spine (HP:0100711)1.97057973
111Distal upper limb amyotrophy (HP:0007149)1.96975722
112Upper limb amyotrophy (HP:0009129)1.96975722
113Abnormal gallbladder morphology (HP:0012437)1.95599510
114Sloping forehead (HP:0000340)1.95510136
115Prominent nose (HP:0000448)1.94232178
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.93763813
117Pointed chin (HP:0000307)1.92711672
118Atelectasis (HP:0100750)1.92656562
119Abnormality of reticulocytes (HP:0004312)1.92033691
120Premature skin wrinkling (HP:0100678)1.91437476
121Overriding aorta (HP:0002623)1.89830757
122Nonimmune hydrops fetalis (HP:0001790)1.89791278
123Small intestinal stenosis (HP:0012848)1.89686400
124Duodenal stenosis (HP:0100867)1.89686400
125Increased muscle lipid content (HP:0009058)1.87789672
126Gastrointestinal inflammation (HP:0004386)1.85856499
127Muscle fibrillation (HP:0010546)1.85781840
128Ectopic kidney (HP:0000086)1.85524022
129Bowel incontinence (HP:0002607)1.85481125
130Cellular immunodeficiency (HP:0005374)1.85343578
131Broad palm (HP:0001169)1.85191642
132Premature graying of hair (HP:0002216)1.84937291
133Delayed epiphyseal ossification (HP:0002663)1.84445206
134Abnormal lung lobation (HP:0002101)1.84403879
135Elfin facies (HP:0004428)1.82931898
136Absent radius (HP:0003974)1.81996640
137Panhypogammaglobulinemia (HP:0003139)1.81914078
138Facial hemangioma (HP:0000329)1.80049892
139Secondary amenorrhea (HP:0000869)1.79555296
140Cerebral palsy (HP:0100021)1.78991685
141Abnormal large intestine physiology (HP:0012700)1.78444991
142Freckling (HP:0001480)1.78218505
143Abnormality of DNA repair (HP:0003254)1.78152382
144T lymphocytopenia (HP:0005403)1.77947744
145Horseshoe kidney (HP:0000085)1.77726149
146Bronchitis (HP:0012387)1.77706624
147Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76994464
148Abnormality of the calcaneus (HP:0008364)1.76327651
149Increased connective tissue (HP:0009025)1.74172062
150Male infertility (HP:0003251)1.74043998
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.73496483
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73223699
153Absent epiphyses (HP:0010577)1.73223699
154Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.73128222
155Partial agenesis of the corpus callosum (HP:0001338)1.72600404
156Cellulitis (HP:0100658)1.72367004
157Easy fatigability (HP:0003388)1.71266578
158Abnormal spermatogenesis (HP:0008669)1.71041587
159Abnormality of the fingertips (HP:0001211)1.70801981
160Abnormality of iron homeostasis (HP:0011031)1.70765617
161Broad face (HP:0000283)1.70724184
162External ophthalmoplegia (HP:0000544)1.70604881
163Abnormality of the carotid arteries (HP:0005344)1.70215871
164Increased cerebral lipofuscin (HP:0011813)1.69522612
165Aplasia/hypoplasia of the humerus (HP:0006507)1.69213445
166Recurrent viral infections (HP:0004429)1.69181769
167Cleft eyelid (HP:0000625)1.68987319
168Hyperammonemia (HP:0001987)1.68985121
169Abnormality of the duodenum (HP:0002246)1.68882699
170Personality changes (HP:0000751)1.68764813
171Pustule (HP:0200039)1.67693771
172Tracheoesophageal fistula (HP:0002575)1.67078721
173Abnormality of the lower motor neuron (HP:0002366)1.66424335
174High pitched voice (HP:0001620)1.66124554
175Spina bifida occulta (HP:0003298)1.65137270
176Diaphragmatic weakness (HP:0009113)1.65117022
177Duplicated collecting system (HP:0000081)1.64961976
178Abnormality of the motor neurons (HP:0002450)1.64723208
179Optic nerve coloboma (HP:0000588)1.61836322
180Hand muscle atrophy (HP:0009130)1.61574872
181Paralysis (HP:0003470)1.60816683
182Polygenic inheritance (HP:0010982)1.59750482
183Rib fusion (HP:0000902)1.59014099
184Fasciculations (HP:0002380)1.58930015
185Obstructive lung disease (HP:0006536)1.58727843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.89340779
2BUB13.74729404
3CDC73.41361278
4WEE13.28231940
5PRPF4B2.77536352
6NEK22.76998082
7EEF2K2.76065034
8PASK2.67068818
9TAOK22.63488247
10SIK12.49988338
11BRSK22.31548412
12PKN22.31232169
13CDK122.21758310
14MAP4K12.18665028
15TSSK62.17945029
16NME22.11368893
17FLT32.05979203
18VRK22.04217079
19MAP3K101.99731607
20IRAK31.99248154
21SRPK11.86252749
22EIF2AK11.82513884
23RPS6KB21.80839745
24TTK1.79369106
25ACVR1B1.69849261
26STK101.67710134
27* ATR1.67623058
28NEK11.61060920
29PLK11.57697981
30CDK71.54724678
31TGFBR11.54445113
32RPS6KA41.46446067
33EIF2AK31.43728050
34TESK21.40032557
35PDK41.39161416
36PDK31.39161416
37BRSK11.38071393
38DYRK31.37810473
39CDK41.35815162
40TRIB31.34932761
41IRAK41.34774444
42PRKD31.33164057
43AURKB1.29533662
44TLK11.28063720
45EPHA21.27747336
46DAPK21.26655732
47PLK41.26518343
48CHEK11.22577353
49TBK11.22034628
50LRRK21.21490004
51SIK21.20336754
52VRK11.19720681
53PIM21.18992088
54STK161.18648228
55ZAP701.16949891
56CDC42BPA1.16334874
57PIM11.14893438
58CHEK21.14590257
59MAP3K81.12322709
60PTK61.09745531
61SIK31.06737188
62PLK31.06566483
63SCYL21.05486447
64JAK31.04982472
65PRKD21.04960946
66ERN11.03366947
67MKNK11.00982385
68CDK81.00524815
69PAK41.00084556
70TESK10.99554760
71WNK40.97596330
72GRK60.95524085
73MAPKAPK30.93001445
74BCKDK0.88471414
75MAP2K60.86721945
76AKT30.85153105
77MAP3K30.83458328
78CDK20.82446035
79BLK0.81065221
80TNK20.80187990
81ATM0.79327695
82IRAK20.79241981
83ALK0.78404705
84BMX0.78221670
85AURKA0.77722993
86BTK0.77538136
87MAP3K110.76728611
88CSF1R0.72547488
89MAPK150.71359832
90MTOR0.71310048
91CCNB10.71174209
92LIMK10.70844585
93CSNK2A20.69801241
94MAP2K30.68882558
95EPHB10.66685248
96KIT0.66212289
97TEC0.66023432
98BRAF0.64484875
99NME10.64176407
100CLK10.64015877
101RPS6KC10.62424387
102RPS6KL10.62424387
103ICK0.62083856
104RPS6KA60.61809262
105TXK0.60675585
106MKNK20.60476351
107TAOK10.60172797
108PDPK10.57573586
109RIPK40.57341400
110CDK90.54033820
111CSNK2A10.53399364
112MAP3K10.53221269
113IRAK10.53071504
114ITK0.52590687
115STK38L0.52306636
116STK40.52155983
117BRD40.51342713
118PAK10.49310213
119MARK20.47952664
120PDK20.47178381
121MELK0.46626065
122CDK10.46614354
123CHUK0.45610074
124MAP2K20.44890637
125DAPK30.43271381
126HIPK20.42654343
127MARK30.42624062
128NEK90.42487387
129KDR0.40647790
130FGFR40.40308584
131PRKCI0.39924711
132MAPK110.39555924
133MAP3K130.38653893
134RPS6KA50.36293814
135RPS6KA10.36192510
136AKT20.35692445
137CDK60.35501219
138TYK20.35363199
139RPS6KA20.35307928
140IKBKB0.35119286
141MAP3K70.33667212
142STK30.33472425
143NLK0.33072846
144ZAK0.33015450
145SYK0.31939114
146DYRK1B0.31685572

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46911659
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78480108
3Mismatch repair_Homo sapiens_hsa034303.75225993
4Spliceosome_Homo sapiens_hsa030403.22098237
5Base excision repair_Homo sapiens_hsa034103.12677607
6RNA transport_Homo sapiens_hsa030133.07692529
7One carbon pool by folate_Homo sapiens_hsa006702.88885807
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.85720446
9Ribosome_Homo sapiens_hsa030102.84264585
10Other glycan degradation_Homo sapiens_hsa005112.70623644
11Homologous recombination_Homo sapiens_hsa034402.62061293
12RNA polymerase_Homo sapiens_hsa030202.58954857
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49470572
14Nucleotide excision repair_Homo sapiens_hsa034202.44792364
15Cell cycle_Homo sapiens_hsa041102.37674912
16Proteasome_Homo sapiens_hsa030502.36272537
17Pyrimidine metabolism_Homo sapiens_hsa002402.14707892
18Fanconi anemia pathway_Homo sapiens_hsa034602.02215114
19Non-homologous end-joining_Homo sapiens_hsa034501.88773911
20Basal transcription factors_Homo sapiens_hsa030221.84955583
21RNA degradation_Homo sapiens_hsa030181.83652061
22Selenocompound metabolism_Homo sapiens_hsa004501.80032797
23mRNA surveillance pathway_Homo sapiens_hsa030151.74906394
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.64759845
25Phenylalanine metabolism_Homo sapiens_hsa003601.53351657
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.43863605
27Antigen processing and presentation_Homo sapiens_hsa046121.40056426
28p53 signaling pathway_Homo sapiens_hsa041151.39158052
29Pentose phosphate pathway_Homo sapiens_hsa000301.34858489
30Sulfur relay system_Homo sapiens_hsa041221.34638117
31Biosynthesis of amino acids_Homo sapiens_hsa012301.33658335
32Primary immunodeficiency_Homo sapiens_hsa053401.24975469
33Epstein-Barr virus infection_Homo sapiens_hsa051691.19536854
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.14019998
35Arginine biosynthesis_Homo sapiens_hsa002201.11022112
36Purine metabolism_Homo sapiens_hsa002301.06968662
37Herpes simplex infection_Homo sapiens_hsa051681.05169761
38Thyroid cancer_Homo sapiens_hsa052161.04159150
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04133843
40Arginine and proline metabolism_Homo sapiens_hsa003301.04019781
41Viral carcinogenesis_Homo sapiens_hsa052031.03795314
42Folate biosynthesis_Homo sapiens_hsa007901.01765211
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.96349730
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95352730
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93737246
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92235879
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88295759
48Legionellosis_Homo sapiens_hsa051340.87011142
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86390200
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83450124
51Carbon metabolism_Homo sapiens_hsa012000.83332205
52Systemic lupus erythematosus_Homo sapiens_hsa053220.81890795
53HTLV-I infection_Homo sapiens_hsa051660.80606923
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80277967
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78432372
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75380600
57N-Glycan biosynthesis_Homo sapiens_hsa005100.74796803
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74615329
59Tyrosine metabolism_Homo sapiens_hsa003500.70999424
60Fructose and mannose metabolism_Homo sapiens_hsa000510.70106239
61VEGF signaling pathway_Homo sapiens_hsa043700.70080724
62Oocyte meiosis_Homo sapiens_hsa041140.67758717
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66579479
64Lysosome_Homo sapiens_hsa041420.65920120
65Vitamin B6 metabolism_Homo sapiens_hsa007500.63316934
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.61912045
67Acute myeloid leukemia_Homo sapiens_hsa052210.61617397
68Galactose metabolism_Homo sapiens_hsa000520.61576363
69Protein export_Homo sapiens_hsa030600.60439968
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60248592
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59584325
72Measles_Homo sapiens_hsa051620.59525659
73Apoptosis_Homo sapiens_hsa042100.55019653
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54916469
75Prion diseases_Homo sapiens_hsa050200.53142322
76Small cell lung cancer_Homo sapiens_hsa052220.51950595
77Endometrial cancer_Homo sapiens_hsa052130.51398639
78Insulin signaling pathway_Homo sapiens_hsa049100.50939935
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.50836220
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50550850
81Pancreatic cancer_Homo sapiens_hsa052120.49984451
82Histidine metabolism_Homo sapiens_hsa003400.48916349
83Hepatitis C_Homo sapiens_hsa051600.45971397
84Notch signaling pathway_Homo sapiens_hsa043300.45869166
85Inositol phosphate metabolism_Homo sapiens_hsa005620.45651691
86Chronic myeloid leukemia_Homo sapiens_hsa052200.44100494
87Shigellosis_Homo sapiens_hsa051310.43451700
88Lysine degradation_Homo sapiens_hsa003100.42103994
89Steroid biosynthesis_Homo sapiens_hsa001000.41335162
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41167600
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41020031
92Hepatitis B_Homo sapiens_hsa051610.40963681
93Fatty acid metabolism_Homo sapiens_hsa012120.40089553
94MicroRNAs in cancer_Homo sapiens_hsa052060.39800944
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39608658
96HIF-1 signaling pathway_Homo sapiens_hsa040660.38941338
97Glutathione metabolism_Homo sapiens_hsa004800.38348160
98Influenza A_Homo sapiens_hsa051640.37141487
99mTOR signaling pathway_Homo sapiens_hsa041500.36935568
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36213614
101B cell receptor signaling pathway_Homo sapiens_hsa046620.36084166
102Fatty acid elongation_Homo sapiens_hsa000620.35880065
103Insulin resistance_Homo sapiens_hsa049310.34350125
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33258318
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.33132839
106Pyruvate metabolism_Homo sapiens_hsa006200.32014637
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.31768838
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31746340
109Colorectal cancer_Homo sapiens_hsa052100.31187312
110Bladder cancer_Homo sapiens_hsa052190.30741710
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.30567700
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29684823
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29611099
114Hematopoietic cell lineage_Homo sapiens_hsa046400.27070550
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26363697
116T cell receptor signaling pathway_Homo sapiens_hsa046600.25096431
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.25095740
118Non-small cell lung cancer_Homo sapiens_hsa052230.19917080
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19029592
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15828375
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13719218
122Metabolic pathways_Homo sapiens_hsa011000.13091729
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11512433
124Alcoholism_Homo sapiens_hsa050340.09499648
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08858476
126TGF-beta signaling pathway_Homo sapiens_hsa043500.08725629
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08567848
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08530377
129Pathways in cancer_Homo sapiens_hsa052000.07267197
130AMPK signaling pathway_Homo sapiens_hsa041520.07137025

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