TVP23A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane protein associated with the Golgi apparatus, which plays a crucial role in intracellular vesicular transport. The encoded protein is likely associated with the late (trans) Golgi compartments, which are involved in the delivery of secretory and membrane proteins to the endosome, lysosome or the plasma membrane. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.48495573
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.29622205
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.20731138
4synaptic vesicle exocytosis (GO:0016079)5.01184237
5vocalization behavior (GO:0071625)4.94989612
6behavioral response to nicotine (GO:0035095)4.93314415
7locomotory exploration behavior (GO:0035641)4.80999355
8regulation of synaptic vesicle exocytosis (GO:2000300)4.69267199
9protein localization to synapse (GO:0035418)4.67108851
10glutamate secretion (GO:0014047)4.63686111
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.63209232
12layer formation in cerebral cortex (GO:0021819)4.56016682
13neuron cell-cell adhesion (GO:0007158)4.54083100
14dendritic spine morphogenesis (GO:0060997)4.38524802
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.36718921
16regulation of synapse structural plasticity (GO:0051823)4.33690169
17regulation of glutamate receptor signaling pathway (GO:1900449)4.29170373
18pyrimidine nucleobase catabolic process (GO:0006208)4.28888088
19cell migration in hindbrain (GO:0021535)4.21657820
20axonal fasciculation (GO:0007413)4.19047002
21neuron recognition (GO:0008038)4.12321211
22exploration behavior (GO:0035640)4.01128410
23regulation of synaptic vesicle transport (GO:1902803)4.00957965
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.99497822
25neurotransmitter secretion (GO:0007269)3.88479971
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.88076807
27proline transport (GO:0015824)3.82153174
28dendrite morphogenesis (GO:0048813)3.81996798
29fucose catabolic process (GO:0019317)3.80124634
30L-fucose metabolic process (GO:0042354)3.80124634
31L-fucose catabolic process (GO:0042355)3.80124634
32regulation of neuronal synaptic plasticity (GO:0048168)3.74425418
33response to pheromone (GO:0019236)3.68967988
34central nervous system projection neuron axonogenesis (GO:0021952)3.65478941
35synaptic transmission, glutamatergic (GO:0035249)3.62862060
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62447495
37protein complex biogenesis (GO:0070271)3.60793077
38neuronal action potential propagation (GO:0019227)3.60066429
39protein-cofactor linkage (GO:0018065)3.59953710
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56256036
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.56256036
42NADH dehydrogenase complex assembly (GO:0010257)3.56256036
43retinal cone cell development (GO:0046549)3.54887744
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54125759
45negative regulation of microtubule polymerization (GO:0031115)3.51945848
46establishment of nucleus localization (GO:0040023)3.49255501
47neurotransmitter-gated ion channel clustering (GO:0072578)3.49125742
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49102326
49indolalkylamine metabolic process (GO:0006586)3.48880471
50response to auditory stimulus (GO:0010996)3.47268991
51synaptic vesicle endocytosis (GO:0048488)3.47183637
52mitochondrial respiratory chain complex assembly (GO:0033108)3.43492627
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.43188771
54water-soluble vitamin biosynthetic process (GO:0042364)3.42719675
55neuron-neuron synaptic transmission (GO:0007270)3.40947751
56cerebellar Purkinje cell layer development (GO:0021680)3.37922249
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36343000
58innervation (GO:0060384)3.36283442
59glutamate receptor signaling pathway (GO:0007215)3.36201559
60nucleobase catabolic process (GO:0046113)3.34276833
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32491091
62platelet dense granule organization (GO:0060155)3.30756110
63regulation of cilium movement (GO:0003352)3.30732796
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30226442
65detection of light stimulus involved in sensory perception (GO:0050962)3.29427594
66detection of light stimulus involved in visual perception (GO:0050908)3.29427594
67auditory behavior (GO:0031223)3.27180477
68ATP synthesis coupled proton transport (GO:0015986)3.24463710
69energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24463710
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24147539
71neuronal action potential (GO:0019228)3.20491206
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17904967
73cerebellar Purkinje cell differentiation (GO:0021702)3.15516577
74positive regulation of synapse maturation (GO:0090129)3.15355262
75neuromuscular process controlling balance (GO:0050885)3.13881384
76postsynaptic membrane organization (GO:0001941)3.13645304
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13497154
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13034017
79DNA double-strand break processing (GO:0000729)3.12929966
80nonmotile primary cilium assembly (GO:0035058)3.12212092
81synapse assembly (GO:0007416)3.10353348
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09579932
83regulation of neurotransmitter secretion (GO:0046928)3.07932767
84neurotransmitter transport (GO:0006836)3.07755768
85photoreceptor cell development (GO:0042461)3.06198200
86regulation of postsynaptic membrane potential (GO:0060078)3.05855647
87activation of protein kinase A activity (GO:0034199)3.05634215
88membrane hyperpolarization (GO:0060081)3.05605825
89membrane depolarization during action potential (GO:0086010)3.05344389
90negative regulation of dendrite development (GO:2000171)3.04291667
91DNA deamination (GO:0045006)3.04052490
92axon cargo transport (GO:0008088)3.03823835
93indole-containing compound catabolic process (GO:0042436)3.02665945
94indolalkylamine catabolic process (GO:0046218)3.02665945
95tryptophan catabolic process (GO:0006569)3.02665945
96cellular potassium ion homeostasis (GO:0030007)3.01413920
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00289225
98positive regulation of synapse assembly (GO:0051965)3.00270026
99respiratory chain complex IV assembly (GO:0008535)2.98591913
100protein localization to cilium (GO:0061512)2.98417821
101gamma-aminobutyric acid transport (GO:0015812)2.98339861
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97377045
103regulation of dendritic spine morphogenesis (GO:0061001)2.96634085
104transmission of nerve impulse (GO:0019226)2.96487016
105sodium ion export (GO:0071436)2.95974693
106preassembly of GPI anchor in ER membrane (GO:0016254)2.95290179
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93688895
108regulation of vesicle fusion (GO:0031338)2.93021243
109neuromuscular process controlling posture (GO:0050884)2.92081538
110cell communication by electrical coupling (GO:0010644)2.91569243
111clathrin coat assembly (GO:0048268)2.91537002
112positive regulation of membrane potential (GO:0045838)2.91119821
113neuronal ion channel clustering (GO:0045161)2.90174033
114neuromuscular process (GO:0050905)2.89937686
115vesicle transport along microtubule (GO:0047496)2.89747499
116long-term memory (GO:0007616)2.89131972
117kynurenine metabolic process (GO:0070189)2.88992252
118regulation of synaptic plasticity (GO:0048167)2.88973972
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88177939
120organelle transport along microtubule (GO:0072384)2.87804638
121regulation of synaptic transmission, glutamatergic (GO:0051966)2.87796640
122regulation of neurotransmitter levels (GO:0001505)2.87006142
123regulation of neurotransmitter transport (GO:0051588)2.85445807
124indole-containing compound metabolic process (GO:0042430)2.84474891
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83928341
126axon extension (GO:0048675)2.82483237
127cerebellar granule cell differentiation (GO:0021707)2.80974184
128protein polyglutamylation (GO:0018095)2.80704337
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80436733
130membrane depolarization (GO:0051899)2.80281090
131negative regulation of axon extension involved in axon guidance (GO:0048843)2.80092518
132negative regulation of telomere maintenance (GO:0032205)2.79690511
133long-term synaptic potentiation (GO:0060291)2.79401748
134dopamine receptor signaling pathway (GO:0007212)2.79221129
135retinal ganglion cell axon guidance (GO:0031290)2.78852372
136behavioral response to ethanol (GO:0048149)2.78337975
137negative regulation of axon guidance (GO:1902668)2.77842548
138startle response (GO:0001964)2.77527682
139establishment of synaptic vesicle localization (GO:0097480)2.77427121
140synaptic vesicle transport (GO:0048489)2.77427121
141presynaptic membrane assembly (GO:0097105)2.76030383
142piRNA metabolic process (GO:0034587)2.75902705
143serotonin metabolic process (GO:0042428)2.73092638
144inner ear receptor stereocilium organization (GO:0060122)2.72521741
145photoreceptor cell maintenance (GO:0045494)2.72481642
146eye photoreceptor cell development (GO:0042462)2.71173806
147synaptic transmission, cholinergic (GO:0007271)2.70769897
148tryptophan metabolic process (GO:0006568)2.67307414
149epithelial cilium movement (GO:0003351)2.65953665
150axoneme assembly (GO:0035082)2.65182045
151cilium morphogenesis (GO:0060271)2.64831550
152presynaptic membrane organization (GO:0097090)2.64817155
153cytochrome complex assembly (GO:0017004)2.63949299
154electron transport chain (GO:0022900)2.62870716
155sulfation (GO:0051923)2.62727510
156cornea development in camera-type eye (GO:0061303)2.60435166
157auditory receptor cell stereocilium organization (GO:0060088)2.60150057
158respiratory electron transport chain (GO:0022904)2.58462561
159mannosylation (GO:0097502)2.57764657
160nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57664741
161cilium organization (GO:0044782)2.56719893
162chaperone-mediated protein transport (GO:0072321)2.56712803
163anterograde synaptic vesicle transport (GO:0048490)2.55203361
164negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54943677
165cAMP catabolic process (GO:0006198)2.53523432
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53282575
167negative regulation of DNA-dependent DNA replication (GO:2000104)2.52122355
168regulation of action potential (GO:0098900)2.51609849
169male meiosis I (GO:0007141)2.50935981
170cilium assembly (GO:0042384)2.49061927
171neurofilament cytoskeleton organization (GO:0060052)2.48855559
172negative regulation of heart rate (GO:0010459)2.48032475
173protein neddylation (GO:0045116)2.47360190
174cellular ketone body metabolic process (GO:0046950)2.47130010
175signal peptide processing (GO:0006465)2.44752284
176neural tube formation (GO:0001841)2.44699200
177regulation of nuclear cell cycle DNA replication (GO:0033262)2.43981277
178DNA methylation involved in gamete generation (GO:0043046)2.42028919
179cilium or flagellum-dependent cell motility (GO:0001539)2.41295334
180recombinational repair (GO:0000725)2.40714490
181primary amino compound metabolic process (GO:1901160)2.40549747
182negative regulation of mast cell activation (GO:0033004)2.40201994
183double-strand break repair via homologous recombination (GO:0000724)2.39943738
184regulation of collateral sprouting (GO:0048670)2.39469746
185cilium movement (GO:0003341)2.38455647
186detection of mechanical stimulus involved in sensory perception (GO:0050974)2.34909852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.31245841
2GBX2_23144817_ChIP-Seq_PC3_Human3.39725376
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14524705
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12683859
5VDR_22108803_ChIP-Seq_LS180_Human3.06362250
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97187053
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80826722
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80826722
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.78864844
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77151948
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74962759
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58956717
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.56516454
14REST_21632747_ChIP-Seq_MESCs_Mouse2.55087548
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52902374
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52232988
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48482234
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47858700
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.47033411
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45031113
21DROSHA_22980978_ChIP-Seq_HELA_Human2.43030973
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40109280
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.39346620
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.37095884
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30732186
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.22569424
27FUS_26573619_Chip-Seq_HEK293_Human2.22058259
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14493227
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.11988141
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.11743809
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07363856
32EWS_26573619_Chip-Seq_HEK293_Human2.00711799
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96796391
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88373362
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87514824
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84026511
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81089139
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80070007
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75839690
40ER_23166858_ChIP-Seq_MCF-7_Human1.73511188
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71097556
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70117339
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.68439020
44TAF15_26573619_Chip-Seq_HEK293_Human1.68082599
45AR_21572438_ChIP-Seq_LNCaP_Human1.66901169
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66595603
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63683292
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59128214
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58390178
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.58384839
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56332595
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55103001
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54361464
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.52928085
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52841551
56BCAT_22108803_ChIP-Seq_LS180_Human1.52581695
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.51071789
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.50465937
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.49905274
60ZNF274_21170338_ChIP-Seq_K562_Hela1.49448762
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47381696
62SMAD4_21799915_ChIP-Seq_A2780_Human1.47182655
63RNF2_27304074_Chip-Seq_NSC_Mouse1.43723109
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42726397
65MYC_18940864_ChIP-ChIP_HL60_Human1.42625013
66TP53_22573176_ChIP-Seq_HFKS_Human1.41550625
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40504640
68CBP_20019798_ChIP-Seq_JUKART_Human1.39844773
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39844773
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.39438922
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37664778
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37541423
73P300_19829295_ChIP-Seq_ESCs_Human1.36795761
74IRF1_19129219_ChIP-ChIP_H3396_Human1.36529573
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31332543
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30972582
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.30712744
78IGF1R_20145208_ChIP-Seq_DFB_Human1.30703360
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29800582
80NANOG_19829295_ChIP-Seq_ESCs_Human1.28354146
81SOX2_19829295_ChIP-Seq_ESCs_Human1.28354146
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27573827
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.27171671
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.26872419
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26224613
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25314577
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23994393
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.23875617
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.23612794
90AR_19668381_ChIP-Seq_PC3_Human1.23248429
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.21780048
92AR_25329375_ChIP-Seq_VCAP_Human1.19891712
93TCF4_22108803_ChIP-Seq_LS180_Human1.19441981
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19135841
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18682829
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17513935
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17418979
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15174918
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14611286
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.14102837
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12083634
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11957114
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11767483
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11557029
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11421055
106STAT3_23295773_ChIP-Seq_U87_Human1.11005854
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09620387
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08934314
109P53_22387025_ChIP-Seq_ESCs_Mouse1.08877436
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08401157
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08319979
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.07244780
113TP53_20018659_ChIP-ChIP_R1E_Mouse1.06752593
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.06525594
115KDM2B_26808549_Chip-Seq_K562_Human1.06036482
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05361435
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.04219655
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03768060
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02760117
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02324225
121VDR_23849224_ChIP-Seq_CD4+_Human1.01867510
122NCOR_22424771_ChIP-Seq_293T_Human1.01840650
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01475562
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01285109
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01245459
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00330960
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00330960
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.99714839
129FOXA1_25329375_ChIP-Seq_VCAP_Human0.99449697
130FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99449697
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.99099252
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99050493
133ELK1_19687146_ChIP-ChIP_HELA_Human0.98540827
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.98114500
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96872616
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96715877
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95845615
138TCF4_23295773_ChIP-Seq_U87_Human0.95807491
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95367849
140ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95339375
141JUN_21703547_ChIP-Seq_K562_Human0.95112083
142RUNX2_22187159_ChIP-Seq_PCA_Human0.94117423
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.92387912
144ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92362399
145AHR_22903824_ChIP-Seq_MCF-7_Human0.91580948
146EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90886392
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90476359
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.90206286
149ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89277874
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86822467
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.86169432
152ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85755619
153TET1_21490601_ChIP-Seq_MESCs_Mouse0.85517264
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85473316
155ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84932844
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83504204
157POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83270570
158CTCF_27219007_Chip-Seq_Bcells_Human0.83073185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.36142917
2MP0003880_abnormal_central_pattern3.88855315
3MP0004270_analgesia3.70003270
4MP0003635_abnormal_synaptic_transmissio3.52578540
5MP0001968_abnormal_touch/_nociception3.39710234
6MP0002735_abnormal_chemical_nociception3.10903855
7MP0005423_abnormal_somatic_nervous3.05436134
8MP0002063_abnormal_learning/memory/cond2.93602269
9MP0002734_abnormal_mechanical_nocicepti2.87200615
10MP0008877_abnormal_DNA_methylation2.84358869
11MP0006276_abnormal_autonomic_nervous2.76216275
12MP0002736_abnormal_nociception_after2.74743602
13MP0009745_abnormal_behavioral_response2.68195690
14MP0002064_seizures2.58267870
15MP0005645_abnormal_hypothalamus_physiol2.53276231
16MP0000778_abnormal_nervous_system2.53120003
17MP0009046_muscle_twitch2.46340971
18MP0002733_abnormal_thermal_nociception2.39041807
19MP0002572_abnormal_emotion/affect_behav2.36521907
20MP0002184_abnormal_innervation2.29707084
21MP0002272_abnormal_nervous_system2.27889056
22MP0001486_abnormal_startle_reflex2.27694667
23MP0004858_abnormal_nervous_system2.22827195
24MP0006292_abnormal_olfactory_placode2.15093071
25MP0001970_abnormal_pain_threshold2.13225372
26MP0003122_maternal_imprinting2.09432408
27MP0003195_calcinosis2.07787147
28MP0001440_abnormal_grooming_behavior1.94046616
29MP0000569_abnormal_digit_pigmentation1.93100107
30MP0000372_irregular_coat_pigmentation1.90752457
31MP0004811_abnormal_neuron_physiology1.90024770
32MP0002067_abnormal_sensory_capabilities1.88936604
33MP0003136_yellow_coat_color1.87790945
34MP0003879_abnormal_hair_cell1.87095520
35MP0008872_abnormal_physiological_respon1.83354429
36MP0009780_abnormal_chondrocyte_physiolo1.75588891
37MP0002557_abnormal_social/conspecific_i1.74356121
38MP0000955_abnormal_spinal_cord1.74151536
39MP0006072_abnormal_retinal_apoptosis1.67158905
40MP0005253_abnormal_eye_physiology1.66614963
41MP0002882_abnormal_neuron_morphology1.61022368
42MP0001529_abnormal_vocalization1.59155871
43MP0001501_abnormal_sleep_pattern1.57422583
44MP0001984_abnormal_olfaction1.57370423
45MP0002938_white_spotting1.53565759
46MP0002837_dystrophic_cardiac_calcinosis1.50652601
47MP0002909_abnormal_adrenal_gland1.49314378
48MP0008569_lethality_at_weaning1.47981883
49MP0003329_amyloid_beta_deposits1.46793690
50MP0005386_behavior/neurological_phenoty1.45182531
51MP0004924_abnormal_behavior1.45182531
52MP0003787_abnormal_imprinting1.43338810
53MP0003011_delayed_dark_adaptation1.39590896
54MP0001348_abnormal_lacrimal_gland1.35305972
55MP0002066_abnormal_motor_capabilities/c1.34025036
56MP0001299_abnormal_eye_distance/1.31917410
57MP0008995_early_reproductive_senescence1.31184318
58MP0004043_abnormal_pH_regulation1.30735867
59MP0008875_abnormal_xenobiotic_pharmacok1.29163445
60MP0005646_abnormal_pituitary_gland1.27504056
61MP0002751_abnormal_autonomic_nervous1.25465773
62MP0002876_abnormal_thyroid_physiology1.24677509
63MP0001502_abnormal_circadian_rhythm1.22401557
64MP0002822_catalepsy1.22297135
65MP0002152_abnormal_brain_morphology1.22107618
66MP0005174_abnormal_tail_pigmentation1.17018271
67MP0004742_abnormal_vestibular_system1.16920742
68MP0005084_abnormal_gallbladder_morpholo1.13825449
69MP0003718_maternal_effect1.09600550
70MP0002752_abnormal_somatic_nervous1.08529390
71MP0002095_abnormal_skin_pigmentation1.08427619
72MP0003646_muscle_fatigue1.08399190
73MP0008058_abnormal_DNA_repair1.07946556
74MP0004145_abnormal_muscle_electrophysio1.06103885
75MP0004147_increased_porphyrin_level1.05363401
76MP0002653_abnormal_ependyma_morphology1.04591172
77MP0003121_genomic_imprinting1.03087621
78MP0000427_abnormal_hair_cycle1.02197143
79MP0003633_abnormal_nervous_system1.01269489
80MP0000631_abnormal_neuroendocrine_gland1.00631587
81MP0004885_abnormal_endolymph0.99719274
82MP0003283_abnormal_digestive_organ0.99671086
83MP0005195_abnormal_posterior_eye0.99603153
84MP0003634_abnormal_glial_cell0.99287245
85MP0005623_abnormal_meninges_morphology0.98085436
86MP0004142_abnormal_muscle_tone0.94883237
87MP0001905_abnormal_dopamine_level0.93701479
88MP0001485_abnormal_pinna_reflex0.92640551
89MP0005499_abnormal_olfactory_system0.91541908
90MP0005394_taste/olfaction_phenotype0.91541908
91MP0003861_abnormal_nervous_system0.90137936
92MP0001346_abnormal_lacrimal_gland0.89151962
93MP0002069_abnormal_eating/drinking_beha0.89146428
94MP0003631_nervous_system_phenotype0.88829854
95MP0002229_neurodegeneration0.88191373
96MP0001986_abnormal_taste_sensitivity0.87651426
97MP0001963_abnormal_hearing_physiology0.87138557
98MP0001177_atelectasis0.86004673
99MP0005410_abnormal_fertilization0.84999102
100MP0005551_abnormal_eye_electrophysiolog0.83949214
101MP0003890_abnormal_embryonic-extraembry0.83569356
102MP0003698_abnormal_male_reproductive0.82195170
103MP0005503_abnormal_tendon_morphology0.81458560
104MP0002102_abnormal_ear_morphology0.80057682
105MP0005171_absent_coat_pigmentation0.79306440
106MP0002928_abnormal_bile_duct0.77591762
107MP0000538_abnormal_urinary_bladder0.77496340
108MP0001764_abnormal_homeostasis0.77057453
109MP0000026_abnormal_inner_ear0.76390543
110MP0005389_reproductive_system_phenotype0.76337393
111MP0002160_abnormal_reproductive_system0.76297826
112MP0002277_abnormal_respiratory_mucosa0.74525480
113MP0000751_myopathy0.73448974
114MP0000534_abnormal_ureter_morphology0.73438471
115MP0004215_abnormal_myocardial_fiber0.72918147
116MP0003137_abnormal_impulse_conducting0.71409052
117MP0002638_abnormal_pupillary_reflex0.69561374
118MP0010386_abnormal_urinary_bladder0.69020168
119MP0004233_abnormal_muscle_weight0.68154636
120MP0001943_abnormal_respiration0.68124688
121MP0003385_abnormal_body_wall0.66380497
122MP0004085_abnormal_heartbeat0.66228422
123MP0000013_abnormal_adipose_tissue0.65964586
124MP0003632_abnormal_nervous_system0.64371957
125MP0008789_abnormal_olfactory_epithelium0.64050350
126MP0001188_hyperpigmentation0.63470006
127MP0008961_abnormal_basal_metabolism0.63182798
128MP0003123_paternal_imprinting0.60880341
129MP0002090_abnormal_vision0.59726025
130MP0002081_perinatal_lethality0.57381603
131MP0010030_abnormal_orbit_morphology0.57256375
132MP0002082_postnatal_lethality0.56802175
133MP0010770_preweaning_lethality0.56802175
134MP0010769_abnormal_survival0.56696494
135MP0004133_heterotaxia0.56241590

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.30849608
2Myokymia (HP:0002411)5.91333696
3Focal seizures (HP:0007359)5.16628913
4Visual hallucinations (HP:0002367)4.70095444
5Absence seizures (HP:0002121)4.19641847
6Pancreatic cysts (HP:0001737)4.09987341
7Pancreatic fibrosis (HP:0100732)3.92899940
8Epileptic encephalopathy (HP:0200134)3.91930871
9Febrile seizures (HP:0002373)3.80810323
10True hermaphroditism (HP:0010459)3.79831460
11Ankle clonus (HP:0011448)3.60737558
12Atonic seizures (HP:0010819)3.58509547
13Dialeptic seizures (HP:0011146)3.55955813
14Congenital stationary night blindness (HP:0007642)3.46895184
15Supranuclear gaze palsy (HP:0000605)3.37967760
16Molar tooth sign on MRI (HP:0002419)3.35938714
17Abnormality of midbrain morphology (HP:0002418)3.35938714
18Action tremor (HP:0002345)3.31830828
19Medial flaring of the eyebrow (HP:0010747)3.29785904
20Progressive cerebellar ataxia (HP:0002073)3.26192503
21Termporal pattern (HP:0011008)3.22788411
22Insidious onset (HP:0003587)3.22788411
23Nephronophthisis (HP:0000090)3.02708013
24Acute necrotizing encephalopathy (HP:0006965)3.00535416
25Generalized tonic-clonic seizures (HP:0002069)2.98370944
26Limb dystonia (HP:0002451)2.88043365
27Impaired vibration sensation in the lower limbs (HP:0002166)2.80964673
28Abnormality of the corticospinal tract (HP:0002492)2.77189430
29Spastic gait (HP:0002064)2.75903106
30Mitochondrial inheritance (HP:0001427)2.71216273
31Type II lissencephaly (HP:0007260)2.70966198
32Abnormality of the renal cortex (HP:0011035)2.70268006
33Urinary urgency (HP:0000012)2.70170902
34Depression (HP:0000716)2.69645203
35Agitation (HP:0000713)2.69391364
36Progressive macrocephaly (HP:0004481)2.68571569
37Stomach cancer (HP:0012126)2.67650751
38Abnormality of the lower motor neuron (HP:0002366)2.66999418
39Abolished electroretinogram (ERG) (HP:0000550)2.66902621
40Abnormality of the renal medulla (HP:0100957)2.66456628
41Truncal ataxia (HP:0002078)2.65700348
42Attenuation of retinal blood vessels (HP:0007843)2.61438678
43Hypoplasia of the brainstem (HP:0002365)2.59866322
44Aplasia/Hypoplasia of the brainstem (HP:0007362)2.59866322
45Acute encephalopathy (HP:0006846)2.59292937
46Mutism (HP:0002300)2.58363432
47Pheochromocytoma (HP:0002666)2.58298857
48Increased CSF lactate (HP:0002490)2.57049366
49Megalencephaly (HP:0001355)2.55487748
50Cystic liver disease (HP:0006706)2.55416839
51Congenital primary aphakia (HP:0007707)2.55323593
52Abnormal mitochondria in muscle tissue (HP:0008316)2.54295847
53Abnormality of the labia minora (HP:0012880)2.54233752
54Urinary bladder sphincter dysfunction (HP:0002839)2.53352977
55Excessive salivation (HP:0003781)2.52960850
56Drooling (HP:0002307)2.52960850
573-Methylglutaconic aciduria (HP:0003535)2.52822347
58Chronic hepatic failure (HP:0100626)2.50658044
59Abnormal eating behavior (HP:0100738)2.50590407
60Pendular nystagmus (HP:0012043)2.48803865
61Anencephaly (HP:0002323)2.48687065
62Polydipsia (HP:0001959)2.48381789
63Abnormal drinking behavior (HP:0030082)2.48381789
64Poor eye contact (HP:0000817)2.44956254
65Papilledema (HP:0001085)2.42869625
66Broad-based gait (HP:0002136)2.41436960
67Nephrogenic diabetes insipidus (HP:0009806)2.40144369
68Torticollis (HP:0000473)2.37126302
69Hypoventilation (HP:0002791)2.36432978
70Lower limb muscle weakness (HP:0007340)2.36016479
71Amblyopia (HP:0000646)2.33496053
72Inability to walk (HP:0002540)2.32721537
73Polyphagia (HP:0002591)2.31455371
74Sclerocornea (HP:0000647)2.29280973
75Genital tract atresia (HP:0001827)2.28813061
76Bony spicule pigmentary retinopathy (HP:0007737)2.28319857
77Genetic anticipation (HP:0003743)2.28134208
78Neuroendocrine neoplasm (HP:0100634)2.26973164
79Colon cancer (HP:0003003)2.26117271
80Amyotrophic lateral sclerosis (HP:0007354)2.23247993
81Hemiparesis (HP:0001269)2.23107561
82Intestinal atresia (HP:0011100)2.23083232
83Hypothermia (HP:0002045)2.21012532
84Hyperventilation (HP:0002883)2.20998166
85Progressive inability to walk (HP:0002505)2.20415503
86EEG with generalized epileptiform discharges (HP:0011198)2.20312031
87Epileptiform EEG discharges (HP:0011182)2.20000327
88Abnormal social behavior (HP:0012433)2.18782858
89Impaired social interactions (HP:0000735)2.18782858
90Vaginal atresia (HP:0000148)2.18559472
91Renal cortical cysts (HP:0000803)2.18170370
92Lissencephaly (HP:0001339)2.15911319
93Ulnar claw (HP:0001178)2.15764485
94Hypsarrhythmia (HP:0002521)2.15239750
95Anxiety (HP:0000739)2.14626187
96Specific learning disability (HP:0001328)2.13526022
97Aplasia/Hypoplasia of the tongue (HP:0010295)2.13355267
98Lipid accumulation in hepatocytes (HP:0006561)2.13266426
99Fetal akinesia sequence (HP:0001989)2.13154159
100Gait imbalance (HP:0002141)2.12723288
101Anosmia (HP:0000458)2.09929837
102Impaired pain sensation (HP:0007328)2.09131194
103Abnormality of pain sensation (HP:0010832)2.09131194
104Decreased central vision (HP:0007663)2.08890516
105Increased hepatocellular lipid droplets (HP:0006565)2.08693295
106Methylmalonic acidemia (HP:0002912)2.08213782
107Oligodactyly (hands) (HP:0001180)2.08132914
108Optic disc pallor (HP:0000543)2.07591816
109Pointed chin (HP:0000307)2.07448175
110Absent/shortened dynein arms (HP:0200106)2.05781005
111Dynein arm defect of respiratory motile cilia (HP:0012255)2.05781005
112Failure to thrive in infancy (HP:0001531)2.04536270
113Male pseudohermaphroditism (HP:0000037)2.03747827
114Narrow nasal bridge (HP:0000446)2.03711504
115Congenital hepatic fibrosis (HP:0002612)2.02629018
116Focal dystonia (HP:0004373)1.99929565
117Decreased circulating renin level (HP:0003351)1.97080040
118Hemiplegia (HP:0002301)1.96872444
119Furrowed tongue (HP:0000221)1.95806847
120Aqueductal stenosis (HP:0002410)1.95623010
121Retinal dysplasia (HP:0007973)1.94110537
122Occipital encephalocele (HP:0002085)1.93905778
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92874002
124Abnormal ciliary motility (HP:0012262)1.92780126
125Gaze-evoked nystagmus (HP:0000640)1.92625031
126Abnormal respiratory motile cilium morphology (HP:0005938)1.92313064
127Abnormal respiratory epithelium morphology (HP:0012253)1.92313064
128Hepatocellular necrosis (HP:0001404)1.91412398
129Hyperthyroidism (HP:0000836)1.91323555
130Dysdiadochokinesis (HP:0002075)1.91239197
131Methylmalonic aciduria (HP:0012120)1.91157085
132Optic nerve hypoplasia (HP:0000609)1.90880196
133Insomnia (HP:0100785)1.90704152
134Dysmetria (HP:0001310)1.89336970
135Polyuria (HP:0000103)1.89145634
136Neurofibrillary tangles (HP:0002185)1.88916057
137Morphological abnormality of the pyramidal tract (HP:0002062)1.88052424
138Congenital, generalized hypertrichosis (HP:0004540)1.87418187
139Craniofacial dystonia (HP:0012179)1.86598989
140Abnormal rod and cone electroretinograms (HP:0008323)1.86594631
141Abnormality of alanine metabolism (HP:0010916)1.85206713
142Hyperalaninemia (HP:0003348)1.85206713
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85206713
144Hypercortisolism (HP:0001578)1.83602369
145Postaxial foot polydactyly (HP:0001830)1.83114567
146Stereotypic behavior (HP:0000733)1.82835124
147Truncus arteriosus (HP:0001660)1.82557228
148Hepatic necrosis (HP:0002605)1.81916647
149Pachygyria (HP:0001302)1.80524965
150Abnormality of salivation (HP:0100755)1.80423468
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.79216890
152Clumsiness (HP:0002312)1.78707853
153Hammertoe (HP:0001765)1.78293600
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77857364
155Large eyes (HP:0001090)1.77628464
156Poor coordination (HP:0002370)1.77612387
157Postaxial hand polydactyly (HP:0001162)1.77102197
158Absent speech (HP:0001344)1.75788403
159Tubular atrophy (HP:0000092)1.75741149
160Akinesia (HP:0002304)1.75641908
161Clonus (HP:0002169)1.75499432
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75422198
163Postural instability (HP:0002172)1.74755811
164Bile duct proliferation (HP:0001408)1.74424102
165Abnormal biliary tract physiology (HP:0012439)1.74424102
166Renal Fanconi syndrome (HP:0001994)1.74238616
167Abnormality of calcium-phosphate metabolism (HP:0100530)1.73778200
168Increased corneal curvature (HP:0100692)1.73087677
169Keratoconus (HP:0000563)1.73087677
170Cerebral inclusion bodies (HP:0100314)1.72620150
171Neoplasm of the heart (HP:0100544)1.72606144
172Small hand (HP:0200055)1.72353712
173Sacral dimple (HP:0000960)1.66530058
174Exotropia (HP:0000577)1.65964537
175Generalized hypotonia (HP:0001290)1.65917078
176Annular pancreas (HP:0001734)1.65857454
177Degeneration of the lateral corticospinal tracts (HP:0002314)1.65049780
178Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65049780
179Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64477744
180Scanning speech (HP:0002168)1.64346257
181Apathy (HP:0000741)1.63559734
182Bradykinesia (HP:0002067)1.63117383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.61299593
2MARK14.46106223
3NTRK33.50862199
4MAP3K93.32774116
5MAP4K23.25141935
6BMPR1B3.18500809
7MINK13.12833859
8SIK32.99284389
9KSR12.72429022
10NTRK22.71421937
11ADRBK22.66041148
12MAP3K42.62724369
13ZAK2.54628648
14TLK12.53696766
15TAOK32.46321848
16EPHA42.31555068
17PAK62.31462221
18NUAK12.29853182
19INSRR2.27262212
20MAP2K72.20185427
21ACVR1B2.19754215
22MAP3K122.13858434
23PINK12.10450568
24KSR21.96562977
25MAPK131.88599359
26CASK1.83518938
27BCR1.83023448
28NTRK11.81876177
29ARAF1.79307908
30DAPK21.76083315
31PHKG21.71078814
32PHKG11.71078814
33GRK11.70077797
34UHMK11.63476766
35MAP2K41.61618746
36PRKD31.57251266
37MKNK21.50473871
38ERBB31.46893356
39CDK51.45320329
40FGFR21.44559777
41OXSR11.44400634
42CAMKK11.42157534
43LATS21.40033271
44DYRK21.35577026
45WNK41.34420108
46SIK21.34350250
47LIMK11.30472422
48TRIM281.29675802
49PAK31.29460390
50TYRO31.25620355
51PLK21.24632957
52LMTK21.20682426
53TXK1.15591040
54PRKCG1.14207798
55NME11.13894366
56CDK181.11997998
57VRK11.11508902
58GRK51.09377980
59STK391.06282836
60CDK141.03648741
61MAP3K20.98821224
62CDK150.97096691
63VRK20.95857774
64MKNK10.94485676
65SGK4940.93846578
66SGK2230.93846578
67DAPK10.91052929
68CSNK1G10.90197718
69STK38L0.89831564
70EPHB20.89165197
71IRAK20.85984768
72RET0.85589194
73CDK11A0.83982948
74FER0.82790032
75CSNK1G20.82677654
76MUSK0.82592454
77CAMKK20.81133876
78EIF2AK30.80936022
79TNIK0.79722621
80MST40.79386750
81PRPF4B0.77794700
82DYRK1A0.77387888
83TGFBR10.75676162
84RPS6KA20.75647251
85TAOK10.74379212
86TNK20.72486548
87BRSK20.72317051
88TIE10.71496225
89TAF10.71402029
90RAF10.71301356
91CAMK2A0.67764410
92MAPKAPK50.67452467
93CDK190.67065841
94PRKCE0.66120408
95PNCK0.65614482
96WNK30.65126610
97BRAF0.63005452
98EIF2AK20.62544115
99RPS6KA50.62171229
100PDGFRA0.62028365
101TEC0.60986625
102STK110.60385269
103PRKCZ0.60117931
104AKT30.59340003
105IKBKB0.58793110
106MAP3K130.58658096
107CAMK2B0.58565577
108PRKCH0.58412619
109CDC42BPA0.58381137
110SGK20.57940341
111MARK20.57721777
112NEK10.57253539
113CCNB10.54632355
114WEE10.54416146
115PLK30.53398031
116CAMK10.51543266
117CSNK1G30.51103732
118STK380.50478423
119CHUK0.50143685
120RIPK40.47969623
121PRKCQ0.47372309
122SGK10.47148308
123PRKACA0.46706938
124MAPK100.46508542
125PKN10.45505468
126MAP2K10.45485921
127ERBB20.44459106
128CSNK1A10.44097886
129NEK20.43576152
130CAMK1G0.43126593
131ROCK20.42961088
132CSNK1A1L0.42748117
133MAPK150.42519191
134MAP2K60.42262595
135FYN0.41305541
136DDR20.41246824
137CAMK40.41005656
138PLK40.40901816
139SCYL20.40528281
140SGK30.40313290
141PRKG10.40210333
142RPS6KA30.39997287
143CSNK1D0.39633554
144GRK70.39483343
145CDK30.39162737
146PTK2B0.36935199
147PRKCI0.36314656
148WNK10.36127074
149PRKACB0.35907604
150BRSK10.35497636
151FES0.35115271
152FGFR10.34874388
153DYRK30.34182464
154ADRBK10.31496858
155RIPK10.30545145

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34074821
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31227912
3Oxidative phosphorylation_Homo sapiens_hsa001903.27308426
4Olfactory transduction_Homo sapiens_hsa047402.72029698
5Parkinsons disease_Homo sapiens_hsa050122.62882662
6GABAergic synapse_Homo sapiens_hsa047272.53571202
7Protein export_Homo sapiens_hsa030602.49823407
8Circadian entrainment_Homo sapiens_hsa047132.42300522
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33873906
10Glutamatergic synapse_Homo sapiens_hsa047242.31986204
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25115250
12Morphine addiction_Homo sapiens_hsa050322.19948720
13Dopaminergic synapse_Homo sapiens_hsa047282.17503320
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.12276618
15Long-term potentiation_Homo sapiens_hsa047202.11948081
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10489579
17Amphetamine addiction_Homo sapiens_hsa050312.08326173
18Homologous recombination_Homo sapiens_hsa034402.02331421
19RNA polymerase_Homo sapiens_hsa030201.95986259
20Butanoate metabolism_Homo sapiens_hsa006501.93354334
21Insulin secretion_Homo sapiens_hsa049111.92959852
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.88408396
23Cholinergic synapse_Homo sapiens_hsa047251.85375932
24Linoleic acid metabolism_Homo sapiens_hsa005911.83653390
25Axon guidance_Homo sapiens_hsa043601.83491020
26Cocaine addiction_Homo sapiens_hsa050301.81714637
27Basal transcription factors_Homo sapiens_hsa030221.81638766
28Huntingtons disease_Homo sapiens_hsa050161.79055424
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78809956
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76354412
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75018390
32Salivary secretion_Homo sapiens_hsa049701.73755910
33Alzheimers disease_Homo sapiens_hsa050101.72005278
34Taste transduction_Homo sapiens_hsa047421.61969459
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61921388
36Serotonergic synapse_Homo sapiens_hsa047261.60812782
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57227638
38Gastric acid secretion_Homo sapiens_hsa049711.54507556
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54381545
40Long-term depression_Homo sapiens_hsa047301.52990081
41Nitrogen metabolism_Homo sapiens_hsa009101.49667368
42Gap junction_Homo sapiens_hsa045401.45020955
43Oxytocin signaling pathway_Homo sapiens_hsa049211.37743649
44GnRH signaling pathway_Homo sapiens_hsa049121.35808375
45Collecting duct acid secretion_Homo sapiens_hsa049661.35366924
46Tryptophan metabolism_Homo sapiens_hsa003801.33394707
47Renin secretion_Homo sapiens_hsa049241.33251647
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.31704252
49Asthma_Homo sapiens_hsa053101.30060574
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28404418
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28293201
52Calcium signaling pathway_Homo sapiens_hsa040201.23028154
53Fanconi anemia pathway_Homo sapiens_hsa034601.23015069
54ErbB signaling pathway_Homo sapiens_hsa040121.22673782
55Glioma_Homo sapiens_hsa052141.20186992
56Melanogenesis_Homo sapiens_hsa049161.20029164
57Ether lipid metabolism_Homo sapiens_hsa005651.19493762
58Vibrio cholerae infection_Homo sapiens_hsa051101.18999762
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15129628
60Propanoate metabolism_Homo sapiens_hsa006401.13283606
61Selenocompound metabolism_Homo sapiens_hsa004501.10594999
62RNA degradation_Homo sapiens_hsa030181.09801321
63Type II diabetes mellitus_Homo sapiens_hsa049301.09169881
64cAMP signaling pathway_Homo sapiens_hsa040241.07726319
65One carbon pool by folate_Homo sapiens_hsa006701.04658022
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04525128
67Caffeine metabolism_Homo sapiens_hsa002321.03850918
68Estrogen signaling pathway_Homo sapiens_hsa049151.02581729
69Regulation of autophagy_Homo sapiens_hsa041401.01730004
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00685639
71Oocyte meiosis_Homo sapiens_hsa041140.98034498
72Proteasome_Homo sapiens_hsa030500.97770269
73Chemical carcinogenesis_Homo sapiens_hsa052040.97104395
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.94363558
75Phototransduction_Homo sapiens_hsa047440.92858465
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91316553
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.89834678
78Ribosome_Homo sapiens_hsa030100.86588092
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85983925
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84544535
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84358601
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.82969364
83Endometrial cancer_Homo sapiens_hsa052130.82665181
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81824955
85Colorectal cancer_Homo sapiens_hsa052100.81304345
86Cardiac muscle contraction_Homo sapiens_hsa042600.80465530
87Peroxisome_Homo sapiens_hsa041460.79923022
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79689976
89MAPK signaling pathway_Homo sapiens_hsa040100.79063298
90Dorso-ventral axis formation_Homo sapiens_hsa043200.78719770
91Alcoholism_Homo sapiens_hsa050340.77481478
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.77147823
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77119774
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76190839
95Retinol metabolism_Homo sapiens_hsa008300.75729318
96Ras signaling pathway_Homo sapiens_hsa040140.72321203
97Choline metabolism in cancer_Homo sapiens_hsa052310.71771582
98Thyroid hormone synthesis_Homo sapiens_hsa049180.71387853
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.71314104
100Dilated cardiomyopathy_Homo sapiens_hsa054140.71140204
101Purine metabolism_Homo sapiens_hsa002300.70945057
102ABC transporters_Homo sapiens_hsa020100.70541496
103VEGF signaling pathway_Homo sapiens_hsa043700.70290980
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69783417
105Wnt signaling pathway_Homo sapiens_hsa043100.69524719
106Ovarian steroidogenesis_Homo sapiens_hsa049130.68223439
107Hedgehog signaling pathway_Homo sapiens_hsa043400.65426308
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65186613
109Rap1 signaling pathway_Homo sapiens_hsa040150.64824495
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.64597565
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63971110
112Hippo signaling pathway_Homo sapiens_hsa043900.63883088
113Arachidonic acid metabolism_Homo sapiens_hsa005900.63793283
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62440855
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62199853
116Graft-versus-host disease_Homo sapiens_hsa053320.62061860
117Type I diabetes mellitus_Homo sapiens_hsa049400.61349954
118Endocytosis_Homo sapiens_hsa041440.60657378
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59716318
120Rheumatoid arthritis_Homo sapiens_hsa053230.59113148
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59109098
122Metabolic pathways_Homo sapiens_hsa011000.58902588
123Basal cell carcinoma_Homo sapiens_hsa052170.58870401
124Allograft rejection_Homo sapiens_hsa053300.58807160
125Melanoma_Homo sapiens_hsa052180.58019472
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57130962
127Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56534599
128Renal cell carcinoma_Homo sapiens_hsa052110.55597142
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55478815
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55143422
131mTOR signaling pathway_Homo sapiens_hsa041500.55059696
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52963952
133Pyrimidine metabolism_Homo sapiens_hsa002400.52908743
134Autoimmune thyroid disease_Homo sapiens_hsa053200.51120558
135Steroid biosynthesis_Homo sapiens_hsa001000.50266006
136Insulin signaling pathway_Homo sapiens_hsa049100.49850338
137Pancreatic secretion_Homo sapiens_hsa049720.49529314
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48799157
139Primary immunodeficiency_Homo sapiens_hsa053400.48576762
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48230207
141Non-small cell lung cancer_Homo sapiens_hsa052230.47976616
142Non-homologous end-joining_Homo sapiens_hsa034500.47677792
143beta-Alanine metabolism_Homo sapiens_hsa004100.47542185
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47223918
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46760094
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46675482
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45918445
148Prion diseases_Homo sapiens_hsa050200.44447788
149Circadian rhythm_Homo sapiens_hsa047100.44002199
150Glucagon signaling pathway_Homo sapiens_hsa049220.43432139
151Glycerolipid metabolism_Homo sapiens_hsa005610.42156405
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40622797
153Phagosome_Homo sapiens_hsa041450.40296703
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39649417
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38712767
156Chemokine signaling pathway_Homo sapiens_hsa040620.38276449
157Folate biosynthesis_Homo sapiens_hsa007900.37925516
158Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36846464
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35391900
160Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35264921
161Mineral absorption_Homo sapiens_hsa049780.34096041
162Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33488553
163Nucleotide excision repair_Homo sapiens_hsa034200.32687961
164Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31254053
165Sulfur metabolism_Homo sapiens_hsa009200.29460336
166Vitamin digestion and absorption_Homo sapiens_hsa049770.29454031

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