TVP23B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)8.54381522
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.76122605
3protein retention in ER lumen (GO:0006621)7.03854182
4COPII vesicle coating (GO:0048208)6.22134005
5protein maturation by protein folding (GO:0022417)5.98983419
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.71773840
7peptide hormone processing (GO:0016486)5.45117162
8endocrine pancreas development (GO:0031018)5.40961593
9ER overload response (GO:0006983)5.39106354
10water-soluble vitamin biosynthetic process (GO:0042364)4.84226151
11exocrine pancreas development (GO:0031017)4.82521837
12sequestering of metal ion (GO:0051238)4.80271770
13cellular ketone body metabolic process (GO:0046950)4.43609315
14glandular epithelial cell differentiation (GO:0002067)4.41020313
15mesenchymal cell differentiation involved in kidney development (GO:0072161)4.40022105
16mesenchymal cell differentiation involved in renal system development (GO:2001012)4.40022105
17nucleotide transmembrane transport (GO:1901679)4.35874483
18regulation of type B pancreatic cell apoptotic process (GO:2000674)4.29981280
19ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.29113341
20regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.24651718
21type B pancreatic cell development (GO:0003323)4.24515003
22ER to Golgi vesicle-mediated transport (GO:0006888)4.20360572
23ketone body metabolic process (GO:1902224)4.15172302
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.11869979
25vesicle coating (GO:0006901)4.09814084
26protein N-linked glycosylation via asparagine (GO:0018279)4.09653014
27peptidyl-asparagine modification (GO:0018196)4.01838337
28GDP-mannose metabolic process (GO:0019673)3.94322041
29positive regulation of nuclease activity (GO:0032075)3.92111957
30respiratory chain complex IV assembly (GO:0008535)3.90755925
31positive regulation of insulin secretion (GO:0032024)3.85283001
32sphingosine metabolic process (GO:0006670)3.84869011
33protein N-linked glycosylation (GO:0006487)3.77406982
34intra-Golgi vesicle-mediated transport (GO:0006891)3.76355865
35toxin metabolic process (GO:0009404)3.76031384
36cellular response to unfolded protein (GO:0034620)3.65881683
37endoplasmic reticulum unfolded protein response (GO:0030968)3.65278466
383-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.63878953
39purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.63878953
40platelet dense granule organization (GO:0060155)3.63416365
41UDP-N-acetylglucosamine metabolic process (GO:0006047)3.63268535
42regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.62514684
43cellular response to topologically incorrect protein (GO:0035967)3.61374178
44regulation of nuclease activity (GO:0032069)3.60247066
45glandular epithelial cell development (GO:0002068)3.56784727
46sphingoid metabolic process (GO:0046519)3.56368328
47diol metabolic process (GO:0034311)3.47778234
48negative regulation of glycoprotein biosynthetic process (GO:0010561)3.44903000
49nucleotide-sugar biosynthetic process (GO:0009226)3.42417505
50relaxation of smooth muscle (GO:0044557)3.41774718
51ER-nucleus signaling pathway (GO:0006984)3.39211589
52dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.35853556
53protein localization to cilium (GO:0061512)3.35305283
54positive regulation of glycolytic process (GO:0045821)3.34310339
55cytochrome complex assembly (GO:0017004)3.30919478
56lactate metabolic process (GO:0006089)3.30085905
57regulation of mitochondrial translation (GO:0070129)3.27684057
58peptide metabolic process (GO:0006518)3.24560872
59regulation of insulin secretion (GO:0050796)3.23494758
60L-phenylalanine catabolic process (GO:0006559)3.20530428
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.20530428
62nucleotide-sugar metabolic process (GO:0009225)3.20523350
63cell redox homeostasis (GO:0045454)3.20093244
64insulin secretion (GO:0030073)3.19361239
65cullin deneddylation (GO:0010388)3.16249669
66response to endoplasmic reticulum stress (GO:0034976)3.16210349
67peptide catabolic process (GO:0043171)3.15794383
68protein localization to Golgi apparatus (GO:0034067)3.15533907
69cellular zinc ion homeostasis (GO:0006882)3.12985512
70positive regulation of peptide hormone secretion (GO:0090277)3.11990752
71negative regulation of neurological system process (GO:0031645)3.11033021
72proteasome assembly (GO:0043248)3.05562256
73regulation of hexokinase activity (GO:1903299)3.05466050
74regulation of glucokinase activity (GO:0033131)3.05466050
75protein deneddylation (GO:0000338)3.04330880
76positive regulation of protein autophosphorylation (GO:0031954)3.04007913
77mannosylation (GO:0097502)3.02642830
78negative regulation of execution phase of apoptosis (GO:1900118)3.01536572
79response to unfolded protein (GO:0006986)3.00605382
80response to topologically incorrect protein (GO:0035966)2.99912172
81columnar/cuboidal epithelial cell development (GO:0002066)2.99751513
82regulation of peptide hormone secretion (GO:0090276)2.99161716
83protein neddylation (GO:0045116)2.99142370
84positive regulation of peptide secretion (GO:0002793)2.98684386
85response to pheromone (GO:0019236)2.96558986
86protein complex biogenesis (GO:0070271)2.94890087
87inositol phosphate catabolic process (GO:0071545)2.93245344
88regulation of peptide secretion (GO:0002791)2.92126442
89branched-chain amino acid catabolic process (GO:0009083)2.91057650
90negative regulation of glycoprotein metabolic process (GO:1903019)2.90458266
91response to redox state (GO:0051775)2.89586284
92response to misfolded protein (GO:0051788)2.88474199
93rRNA catabolic process (GO:0016075)2.88322990
94keratinocyte development (GO:0003334)2.87297041
95positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.86012162
96dopamine biosynthetic process (GO:0042416)2.85812906
97chaperone-mediated protein folding (GO:0061077)2.85224686
98prenylation (GO:0097354)2.85081414
99protein prenylation (GO:0018342)2.85081414
100negative regulation of JUN kinase activity (GO:0043508)2.84214852
101positive regulation of actin filament depolymerization (GO:0030836)2.82900393
102nucleotide transport (GO:0006862)2.82838102
103intraciliary transport (GO:0042073)2.82080046
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81734747
105positive regulation of meiosis (GO:0045836)2.81597815
106Golgi vesicle transport (GO:0048193)2.81262449
107regulation of meiosis I (GO:0060631)2.80780747
108nitric oxide mediated signal transduction (GO:0007263)2.80325144
109inositol phosphate dephosphorylation (GO:0046855)2.78847924
110phosphorylated carbohydrate dephosphorylation (GO:0046838)2.78847924
111catecholamine biosynthetic process (GO:0042423)2.78681776
112catechol-containing compound biosynthetic process (GO:0009713)2.78681776
1134-hydroxyproline metabolic process (GO:0019471)2.78674584
114regulation of oxidative phosphorylation (GO:0002082)2.78567598
115piRNA metabolic process (GO:0034587)2.78475620
116negative regulation of complement activation (GO:0045916)2.78090713
117polyol catabolic process (GO:0046174)2.72230166
118regulation of hormone secretion (GO:0046883)2.71463167
119behavioral response to nicotine (GO:0035095)2.70418980
120regulation of penile erection (GO:0060405)2.69784049
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69066343
122L-phenylalanine metabolic process (GO:0006558)2.69066343
123regulation of glucocorticoid secretion (GO:2000849)2.68785332
124preassembly of GPI anchor in ER membrane (GO:0016254)2.67884072
125positive regulation of hormone secretion (GO:0046887)2.67281851
126proline biosynthetic process (GO:0006561)2.64651191
127pteridine-containing compound biosynthetic process (GO:0042559)2.62625389
128magnesium ion transport (GO:0015693)2.62420433
129positive regulation of meiotic cell cycle (GO:0051446)2.62413090
130DNA deamination (GO:0045006)2.62354995
131mitochondrial respiratory chain complex assembly (GO:0033108)2.61311776
132misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.60949105
133pyrimidine-containing compound transmembrane transport (GO:0072531)2.60428391
134axoneme assembly (GO:0035082)2.59295449
135C-terminal protein lipidation (GO:0006501)2.58820024
136cellular response to vitamin D (GO:0071305)2.58343945
137maintenance of protein localization in organelle (GO:0072595)2.57961156
138protein autoprocessing (GO:0016540)2.57041410
139S-adenosylmethionine metabolic process (GO:0046500)2.56553812
140regulation of Golgi to plasma membrane protein transport (GO:0042996)2.56006127
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55731841
142peptidyl-histidine modification (GO:0018202)2.55586626
143fucose metabolic process (GO:0006004)2.55484583
144L-ascorbic acid metabolic process (GO:0019852)2.55465415
145regulation of cilium movement (GO:0003352)2.55420153
146lipid particle organization (GO:0034389)2.54615147
147zinc ion transport (GO:0006829)2.54131333
148adenosine metabolic process (GO:0046085)2.52642361
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51584272
150adaptation of signaling pathway (GO:0023058)2.50839893
151xenobiotic catabolic process (GO:0042178)2.48084897
152protein K11-linked deubiquitination (GO:0035871)2.46576413
153negative regulation of protein activation cascade (GO:2000258)2.45868329
154negative regulation of acute inflammatory response (GO:0002674)2.44149230
155fucose catabolic process (GO:0019317)2.43656539
156L-fucose metabolic process (GO:0042354)2.43656539
157L-fucose catabolic process (GO:0042355)2.43656539
158C-terminal protein amino acid modification (GO:0018410)2.41616950
159negative regulation of hormone biosynthetic process (GO:0032353)2.41093043
160establishment of protein localization to mitochondrial membrane (GO:0090151)2.39627731
161mitochondrial respiratory chain complex I assembly (GO:0032981)2.37318275
162NADH dehydrogenase complex assembly (GO:0010257)2.37318275
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.37318275
164artery smooth muscle contraction (GO:0014824)2.37286295
165mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.36976878
166cilium morphogenesis (GO:0060271)2.36793805
167dopamine transport (GO:0015872)2.36598282
168photoreceptor cell maintenance (GO:0045494)2.35506071
169regulation of cellular amino acid metabolic process (GO:0006521)2.35083928
170GPI anchor metabolic process (GO:0006505)2.34907290
171somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.34301305
172somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.34301305
173isotype switching (GO:0045190)2.34301305
174vitamin biosynthetic process (GO:0009110)2.33477797
175negative regulation of telomere maintenance (GO:0032205)2.33312336
176inositol phosphate-mediated signaling (GO:0048016)2.30513403
177COPI coating of Golgi vesicle (GO:0048205)10.1554951
178Golgi transport vesicle coating (GO:0048200)10.1554951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.27300953
2PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.33135224
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.59893493
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52374131
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18397749
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.08369855
7GATA1_22025678_ChIP-Seq_K562_Human2.86906888
8ZNF274_21170338_ChIP-Seq_K562_Hela2.68150159
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62136602
10DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.60992540
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46061054
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.39105747
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.33417404
14GBX2_23144817_ChIP-Seq_PC3_Human2.30724064
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29136320
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25756255
17EWS_26573619_Chip-Seq_HEK293_Human2.21150167
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06781238
19FUS_26573619_Chip-Seq_HEK293_Human2.06419930
20TAF15_26573619_Chip-Seq_HEK293_Human2.02412248
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00768873
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00108816
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.94911086
24P300_19829295_ChIP-Seq_ESCs_Human1.93133248
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.87289451
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87131212
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82449114
28ELK1_19687146_ChIP-ChIP_HELA_Human1.77527284
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75603225
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74489926
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73163028
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71840000
33VDR_22108803_ChIP-Seq_LS180_Human1.71737083
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70752294
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70050314
36ER_23166858_ChIP-Seq_MCF-7_Human1.65964912
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.65713154
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.65150016
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.59052958
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58188346
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57774687
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57750501
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.57609638
44SMAD4_21799915_ChIP-Seq_A2780_Human1.55547844
45IGF1R_20145208_ChIP-Seq_DFB_Human1.55099806
46VDR_23849224_ChIP-Seq_CD4+_Human1.52606854
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52158514
48BCAT_22108803_ChIP-Seq_LS180_Human1.51760228
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50191470
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48512608
51FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.47955715
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47684383
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47242748
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45704212
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45339214
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44416897
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43381613
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.42489418
59CDX2_22108803_ChIP-Seq_LS180_Human1.41309624
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40735700
61CBP_20019798_ChIP-Seq_JUKART_Human1.40735700
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.39370536
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.39355884
64SOX2_20726797_ChIP-Seq_SW620_Human1.37344397
65REST_19997604_ChIP-ChIP_NEURONS_Mouse1.36921788
66AR_25329375_ChIP-Seq_VCAP_Human1.35976421
67GABP_19822575_ChIP-Seq_HepG2_Human1.35668823
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33732970
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32034998
70STAT3_23295773_ChIP-Seq_U87_Human1.31563597
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.31079152
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30377367
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28924031
74TP53_22573176_ChIP-Seq_HFKS_Human1.28090406
75ERG_20517297_ChIP-Seq_VCAP_Human1.28038854
76P53_22387025_ChIP-Seq_ESCs_Mouse1.27399530
77TFEB_21752829_ChIP-Seq_HELA_Human1.27021996
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26968683
79DCP1A_22483619_ChIP-Seq_HELA_Human1.26697325
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.26643525
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25735760
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25212781
83FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25070250
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24771519
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23726487
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.22526390
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21916776
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20513373
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.20139739
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19074096
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19074096
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18727967
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18393881
94TCF4_22108803_ChIP-Seq_LS180_Human1.18160936
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.18101602
96AR_20517297_ChIP-Seq_VCAP_Human1.17224592
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17172956
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.16370247
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16341156
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.16011122
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.15965950
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15516171
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15485250
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15390218
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14614992
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.14381460
107PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14260706
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13982579
109TCF4_23295773_ChIP-Seq_U87_Human1.13917138
110P300_18555785_Chip-Seq_ESCs_Mouse1.13762210
111LXR_22158963_ChIP-Seq_LIVER_Mouse1.13405887
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.11482761
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09397346
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09396151
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08845004
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07780912
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.07326746
118SOX17_20123909_ChIP-Seq_XEN_Mouse1.07131555
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06645346
120HTT_18923047_ChIP-ChIP_STHdh_Human1.05609731
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02888701
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02235589
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.02203529
124CJUN_26792858_Chip-Seq_BT549_Human1.01437501
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01083411
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00144321
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00009869
128ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99814074
129FOXP3_21729870_ChIP-Seq_TREG_Human0.99366813
130PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98432095
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.98350581
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97945684
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.97905590
134CLOCK_20551151_ChIP-Seq_293T_Human0.96581735
135THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94258551
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93297662
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89950296
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.89943249
139FOXA1_25329375_ChIP-Seq_VCAP_Human0.88880589
140FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88880589
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88513519
142NANOG_19829295_ChIP-Seq_ESCs_Human0.87479974
143SOX2_19829295_ChIP-Seq_ESCs_Human0.87479974
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86253053
145GATA4_25053715_ChIP-Seq_YYC3_Human0.85611312
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84498373
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83061478
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.82139165
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81741069
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81636882
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.81404127
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.81236259
153SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81205784
154TAL1_26923725_Chip-Seq_HPCs_Mouse0.80906108
155SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79776736
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79634380
157TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79392077
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78615759
159TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78484679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue4.16952760
2MP0004043_abnormal_pH_regulation3.97449730
3MP0003195_calcinosis3.93815378
4MP0002877_abnormal_melanocyte_morpholog3.83833893
5MP0010386_abnormal_urinary_bladder3.83196893
6MP0003183_abnormal_peptide_metabolism3.51288873
7MP0005379_endocrine/exocrine_gland_phen3.45750792
8MP0009780_abnormal_chondrocyte_physiolo3.38834350
9MP0002693_abnormal_pancreas_physiology3.34045050
10MP0001944_abnormal_pancreas_morphology3.20709156
11MP0005220_abnormal_exocrine_pancreas2.96183060
12MP0000678_abnormal_parathyroid_gland2.87148710
13MP0002102_abnormal_ear_morphology2.85434633
14MP0002909_abnormal_adrenal_gland2.69885417
15MP0003283_abnormal_digestive_organ2.69544792
16MP0010234_abnormal_vibrissa_follicle2.46364195
17MP0005646_abnormal_pituitary_gland2.37413947
18MP0002837_dystrophic_cardiac_calcinosis2.27333510
19MP0008877_abnormal_DNA_methylation2.26638743
20MP0006054_spinal_hemorrhage2.24737506
21MP0003950_abnormal_plasma_membrane2.24386933
22MP0005365_abnormal_bile_salt2.24200965
23MP0000427_abnormal_hair_cycle2.19258129
24MP0006072_abnormal_retinal_apoptosis2.13978863
25MP0002638_abnormal_pupillary_reflex2.11996682
26MP0001986_abnormal_taste_sensitivity2.09205499
27MP0002139_abnormal_hepatobiliary_system2.07443930
28MP0000569_abnormal_digit_pigmentation2.01845415
29MP0003806_abnormal_nucleotide_metabolis1.96459911
30MP0005408_hypopigmentation1.94266318
31MP0003122_maternal_imprinting1.89898617
32MP0004264_abnormal_extraembryonic_tissu1.83650587
33MP0001666_abnormal_nutrient_absorption1.82325337
34MP0002876_abnormal_thyroid_physiology1.80365219
35MP0002078_abnormal_glucose_homeostasis1.78918877
36MP0010678_abnormal_skin_adnexa1.77901715
37MP0005084_abnormal_gallbladder_morpholo1.77800708
38MP0000516_abnormal_urinary_system1.75810040
39MP0005367_renal/urinary_system_phenotyp1.75810040
40MP0003868_abnormal_feces_composition1.75207082
41MP0000003_abnormal_adipose_tissue1.73563028
42MP0005551_abnormal_eye_electrophysiolog1.69799779
43MP0008058_abnormal_DNA_repair1.69613555
44MP0005058_abnormal_lysosome_morphology1.62969225
45MP0000613_abnormal_salivary_gland1.61881250
46MP0005645_abnormal_hypothalamus_physiol1.59034132
47MP0005636_abnormal_mineral_homeostasis1.58059281
48MP0002090_abnormal_vision1.55463103
49MP0009643_abnormal_urine_homeostasis1.54416558
50MP0002896_abnormal_bone_mineralization1.52793167
51MP0003786_premature_aging1.51934388
52MP0002163_abnormal_gland_morphology1.49513289
53MP0002254_reproductive_system_inflammat1.48758654
54MP0001765_abnormal_ion_homeostasis1.47219903
55MP0008872_abnormal_physiological_respon1.44662519
56MP0010329_abnormal_lipoprotein_level1.42210499
57MP0003186_abnormal_redox_activity1.39526259
58MP0000383_abnormal_hair_follicle1.38097223
59MP0004215_abnormal_myocardial_fiber1.35018733
60MP0002138_abnormal_hepatobiliary_system1.33014057
61MP0000462_abnormal_digestive_system1.32922876
62MP0003172_abnormal_lysosome_physiology1.31642458
63MP0005171_absent_coat_pigmentation1.28869612
64MP0004147_increased_porphyrin_level1.27907379
65MP0003718_maternal_effect1.25340834
66MP0003953_abnormal_hormone_level1.21330747
67MP0009046_muscle_twitch1.20904889
68MP0001756_abnormal_urination1.18885478
69MP0005174_abnormal_tail_pigmentation1.18185756
70MP0004782_abnormal_surfactant_physiolog1.16848787
71MP0001764_abnormal_homeostasis1.14093419
72MP0001270_distended_abdomen1.13250737
73MP0000631_abnormal_neuroendocrine_gland1.12524882
74MP0005085_abnormal_gallbladder_physiolo1.10964194
75MP0002295_abnormal_pulmonary_circulatio1.08271557
76MP0009384_cardiac_valve_regurgitation1.07118654
77MP0002160_abnormal_reproductive_system1.06811911
78MP0000230_abnormal_systemic_arterial1.06567479
79MP0006036_abnormal_mitochondrial_physio1.06162946
80MP0000639_abnormal_adrenal_gland1.05345924
81MP0005389_reproductive_system_phenotype1.05327423
82MP0001664_abnormal_digestion1.04266053
83MP0005332_abnormal_amino_acid1.03822696
84MP0000372_irregular_coat_pigmentation1.02874644
85MP0000538_abnormal_urinary_bladder1.02331775
86MP0000163_abnormal_cartilage_morphology1.01904219
87MP0005075_abnormal_melanosome_morpholog1.01684794
88MP0000681_abnormal_thyroid_gland0.98039072
89MP0008875_abnormal_xenobiotic_pharmacok0.96882974
90MP0002928_abnormal_bile_duct0.96160664
91MP0010307_abnormal_tumor_latency0.95809501
92MP0009697_abnormal_copulation0.95246140
93MP0000358_abnormal_cell_content/0.94992105
94MP0003959_abnormal_lean_body0.94989031
95MP0002938_white_spotting0.94281676
96MP0006035_abnormal_mitochondrial_morpho0.94226187
97MP0004084_abnormal_cardiac_muscle0.93796083
98MP0005410_abnormal_fertilization0.93595201
99MP0005535_abnormal_body_temperature0.93585450
100MP0005253_abnormal_eye_physiology0.93541360
101MP0010352_gastrointestinal_tract_polyps0.92902541
102MP0005395_other_phenotype0.90665713
103MP0001873_stomach_inflammation0.89060844
104MP0003795_abnormal_bone_structure0.87768061
105MP0004019_abnormal_vitamin_homeostasis0.87568203
106MP0004142_abnormal_muscle_tone0.86487490
107MP0003252_abnormal_bile_duct0.84830737
108MP0005083_abnormal_biliary_tract0.84211828
109MP0002095_abnormal_skin_pigmentation0.81898372
110MP0000647_abnormal_sebaceous_gland0.80742164
111MP0002168_other_aberrant_phenotype0.80258119
112MP0001905_abnormal_dopamine_level0.80225984
113MP0001542_abnormal_bone_strength0.79576856
114MP0003045_fibrosis0.79158527
115MP0002933_joint_inflammation0.78728951
116MP0002736_abnormal_nociception_after0.76876551
117MP0002234_abnormal_pharynx_morphology0.76042948
118MP0000371_diluted_coat_color0.74864711
119MP0002118_abnormal_lipid_homeostasis0.71807702
120MP0001929_abnormal_gametogenesis0.68498560
121MP0004133_heterotaxia0.68068467
122MP0001299_abnormal_eye_distance/0.67548208
123MP0003724_increased_susceptibility_to0.67113069
124MP0000653_abnormal_sex_gland0.65332376
125MP0003136_yellow_coat_color0.64281625
126MP0002115_abnormal_skeleton_extremities0.63545292
127MP0003011_delayed_dark_adaptation0.63279704
128MP0005448_abnormal_energy_balance0.63226938
129MP0008004_abnormal_stomach_pH0.62890361
130MP0002098_abnormal_vibrissa_morphology0.61909654
131MP0004134_abnormal_chest_morphology0.61236912
132MP0001984_abnormal_olfaction0.61155010
133MP0001661_extended_life_span0.60166977
134MP0001502_abnormal_circadian_rhythm0.57577374
135MP0009642_abnormal_blood_homeostasis0.56439584
136MP0005310_abnormal_salivary_gland0.55537831
137MP0001919_abnormal_reproductive_system0.54440806
138MP0002751_abnormal_autonomic_nervous0.52699419
139MP0001186_pigmentation_phenotype0.52357950
140MP0002177_abnormal_outer_ear0.52337437
141MP0001881_abnormal_mammary_gland0.50775295
142MP0005508_abnormal_skeleton_morphology0.49379108
143MP0006292_abnormal_olfactory_placode0.45961883

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.78326721
2Hypoglycemic seizures (HP:0002173)5.68572684
3Symptomatic seizures (HP:0011145)5.64903235
4Hypoglycemic coma (HP:0001325)5.52909095
5Generalized aminoaciduria (HP:0002909)4.77930587
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.37577233
7Asymmetry of the thorax (HP:0001555)4.09020810
8Insulin-resistant diabetes mellitus (HP:0000831)3.74936601
9Ketoacidosis (HP:0001993)3.68267899
10Abnormality of the pancreatic islet cells (HP:0006476)3.63091074
11Abnormality of endocrine pancreas physiology (HP:0012093)3.63091074
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.60360293
13Abnormality of the intrinsic pathway (HP:0010989)3.58019908
14Pancreatic islet-cell hyperplasia (HP:0004510)3.57228043
15Hyperglycemia (HP:0003074)3.55927741
16Abnormal pancreas size (HP:0012094)3.51816146
17Hypothermia (HP:0002045)3.38025734
18Large for gestational age (HP:0001520)3.37778531
19Renal cortical cysts (HP:0000803)3.36627882
20Unilateral renal agenesis (HP:0000122)3.36022313
21Abnormal protein glycosylation (HP:0012346)3.26608585
22Abnormal glycosylation (HP:0012345)3.26608585
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.26608585
24Abnormal protein N-linked glycosylation (HP:0012347)3.26608585
25Abnormality of calcium-phosphate metabolism (HP:0100530)3.26160760
26Type I transferrin isoform profile (HP:0003642)3.16632322
27Late onset (HP:0003584)3.00086467
28Abnormality of the renal cortex (HP:0011035)3.00060707
29Fibular aplasia (HP:0002990)2.90153545
30Flat capital femoral epiphysis (HP:0003370)2.87567645
31Pancreatic cysts (HP:0001737)2.85858156
32Conjugated hyperbilirubinemia (HP:0002908)2.85538245
33Methylmalonic acidemia (HP:0002912)2.84331276
34Fibular hypoplasia (HP:0003038)2.78729683
35Tongue fasciculations (HP:0001308)2.76253738
36Dysostosis multiplex (HP:0000943)2.75024276
37Pheochromocytoma (HP:0002666)2.73390159
38Epiphyseal dysplasia (HP:0002656)2.66836350
39Congenital, generalized hypertrichosis (HP:0004540)2.60921927
40Neoplasm of the adrenal cortex (HP:0100641)2.60339630
41Protuberant abdomen (HP:0001538)2.55360140
423-Methylglutaconic aciduria (HP:0003535)2.50108754
43Neuroendocrine neoplasm (HP:0100634)2.49315091
44Gait imbalance (HP:0002141)2.49079692
45Irregular vertebral endplates (HP:0003301)2.45828893
46Ketosis (HP:0001946)2.45750680
47Thoracolumbar scoliosis (HP:0002944)2.45566795
48Glycosuria (HP:0003076)2.45296044
49Abnormality of urine glucose concentration (HP:0011016)2.45296044
50Neoplasm of the adrenal gland (HP:0100631)2.43726903
51Molar tooth sign on MRI (HP:0002419)2.43050805
52Abnormality of midbrain morphology (HP:0002418)2.43050805
53Urinary glycosaminoglycan excretion (HP:0003541)2.42897984
54Mucopolysacchariduria (HP:0008155)2.42897984
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42662718
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42662718
57Abnormality of the fovea (HP:0000493)2.39338156
58Nephrogenic diabetes insipidus (HP:0009806)2.39198285
59Progressive neurologic deterioration (HP:0002344)2.38209549
60Methylmalonic aciduria (HP:0012120)2.35439086
61Hypoplasia of the fovea (HP:0007750)2.34441559
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.34441559
63Aplasia/Hypoplasia of the macula (HP:0008059)2.33752141
64Abnormal tarsal ossification (HP:0008369)2.33256847
65Increased CSF lactate (HP:0002490)2.33166306
66Hepatic necrosis (HP:0002605)2.32563043
67Beaking of vertebral bodies (HP:0004568)2.31214436
68Hypokalemia (HP:0002900)2.29508601
69Acute necrotizing encephalopathy (HP:0006965)2.28792994
70Tubulointerstitial nephritis (HP:0001970)2.28101395
71True hermaphroditism (HP:0010459)2.26651953
72Nephronophthisis (HP:0000090)2.26508370
73Gout (HP:0001997)2.26230238
74Agitation (HP:0000713)2.26157854
75Abnormal mitochondria in muscle tissue (HP:0008316)2.25907884
76Decreased circulating renin level (HP:0003351)2.25547511
77Osteomalacia (HP:0002749)2.24834868
78Abnormality of the vertebral endplates (HP:0005106)2.23360215
79Hypomagnesemia (HP:0002917)2.23188984
80Vacuolated lymphocytes (HP:0001922)2.18522162
81Hyperphosphatemia (HP:0002905)2.18235819
82Conjunctival hamartoma (HP:0100780)2.17757653
83Palpitations (HP:0001962)2.17289576
84Insulin resistance (HP:0000855)2.16142900
85Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15642814
86Abdominal distention (HP:0003270)2.15041725
87Progressive inability to walk (HP:0002505)2.14758050
88Muscle fibrillation (HP:0010546)2.14673623
89Abnormality of polysaccharide metabolism (HP:0011012)2.14176977
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14176977
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14176977
92Aplasia/Hypoplasia affecting the retina (HP:0008061)2.13746114
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11662222
94Furrowed tongue (HP:0000221)2.11539156
95Hamartoma of the eye (HP:0010568)2.09108767
96Acute encephalopathy (HP:0006846)2.08848435
97Abnormality of methionine metabolism (HP:0010901)2.08303224
98Abnormality of the common coagulation pathway (HP:0010990)2.08011166
99Chronic bronchitis (HP:0004469)2.06867971
100Disproportionate short-trunk short stature (HP:0003521)2.06237516
101Reduced antithrombin III activity (HP:0001976)2.05451544
102Abnormal albumin level (HP:0012116)2.05269482
103Hypoalbuminemia (HP:0003073)2.05269482
104Metaphyseal irregularity (HP:0003025)2.03942382
105Delayed gross motor development (HP:0002194)2.02198949
106Dysautonomia (HP:0002459)2.02086059
107Limb hypertonia (HP:0002509)2.01438838
108Abnormal drinking behavior (HP:0030082)2.00608252
109Polydipsia (HP:0001959)2.00608252
110Bilateral microphthalmos (HP:0007633)1.99656722
111Abnormality of the renal medulla (HP:0100957)1.99466067
112Abolished electroretinogram (ERG) (HP:0000550)1.99401723
113Abnormal foot bone ossification (HP:0010675)1.97605035
114Delayed epiphyseal ossification (HP:0002663)1.96776622
115Congenital stationary night blindness (HP:0007642)1.96032340
116Irregular epiphyses (HP:0010582)1.95467287
117Hyperphosphaturia (HP:0003109)1.94977732
118Abnormality of purine metabolism (HP:0004352)1.94949443
119Metaphyseal dysplasia (HP:0100255)1.94906692
120Aplasia/Hypoplasia of the fibula (HP:0006492)1.94602547
121Proximal tubulopathy (HP:0000114)1.94539171
122Genital tract atresia (HP:0001827)1.93420322
123Attenuation of retinal blood vessels (HP:0007843)1.93320117
124Hyperparathyroidism (HP:0000843)1.92058575
125Prolonged partial thromboplastin time (HP:0003645)1.92058253
126Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90885328
127Abnormality of fatty-acid metabolism (HP:0004359)1.90596943
128Abnormality of the anterior horn cell (HP:0006802)1.90080003
129Degeneration of anterior horn cells (HP:0002398)1.90080003
130Gaze-evoked nystagmus (HP:0000640)1.87462478
131Delayed closure of the anterior fontanelle (HP:0001476)1.86678918
132Respiratory failure (HP:0002878)1.86585109
133Tubular atrophy (HP:0000092)1.84949396
134Abnormality of renal resorption (HP:0011038)1.84209015
135Vaginal atresia (HP:0000148)1.83522428
136Hepatocellular necrosis (HP:0001404)1.83502139
137Enlarged epiphyses (HP:0010580)1.81494916
138Fair hair (HP:0002286)1.80769322
139Medial flaring of the eyebrow (HP:0010747)1.80393199
140Epiphyseal stippling (HP:0010655)1.80350270
141Progressive macrocephaly (HP:0004481)1.79727025
142Abnormality of macular pigmentation (HP:0008002)1.79072952
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.78828355
144Intestinal atresia (HP:0011100)1.77833545
145Mitochondrial inheritance (HP:0001427)1.77069171
146Abnormal epiphyseal ossification (HP:0010656)1.76336086
147Hyperactive renin-angiotensin system (HP:0000841)1.74699972
148Hepatoblastoma (HP:0002884)1.74413588
149EEG with generalized epileptiform discharges (HP:0011198)1.74219399
150Intrahepatic cholestasis (HP:0001406)1.72442524
151Muscular hypotonia of the trunk (HP:0008936)1.71116976
152Abnormality of vitamin B metabolism (HP:0004340)1.69303959
153Hypoplasia of the uterus (HP:0000013)1.68831242
154Pancreatic fibrosis (HP:0100732)1.68482524
155Aplasia/hypoplasia of the uterus (HP:0008684)1.68155435
156Epileptiform EEG discharges (HP:0011182)1.67907211
157Hypsarrhythmia (HP:0002521)1.67899355
158Congenital primary aphakia (HP:0007707)1.67461640
159Exocrine pancreatic insufficiency (HP:0001738)1.66476119
160Retinal atrophy (HP:0001105)1.66180408
161Abnormal pupillary function (HP:0007686)1.63660842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.71900167
2MAPK154.53683314
3PASK4.44519690
4FRK3.91201657
5MAP4K22.82434354
6EIF2AK32.76663927
7WNK42.57185095
8WNK32.35968806
9ACVR1B2.34126078
10TAOK32.30537212
11FLT32.25739041
12IRAK32.04789200
13PIK3CG2.04444409
14BCKDK2.02954014
15ZAK1.98471949
16MAP3K21.94713191
17TRIM281.92580347
18STK161.90211485
19PRKD31.85285420
20EIF2AK11.80934052
21TAF11.79816174
22MAP3K121.77937552
23AKT31.77920933
24FGFR21.74400079
25HIPK21.67647930
26VRK21.65999469
27MKNK21.59672377
28IRAK11.48536534
29IRAK21.44978939
30BRSK21.44668786
31BCR1.42090929
32NME11.41704526
33STK38L1.41248085
34MET1.40959638
35ERN11.39557351
36PINK11.25678747
37BMPR1B1.25120966
38BMPR21.24216219
39MAP3K31.19935676
40NTRK11.15745788
41TRPM71.14731897
42TESK11.11876211
43BRAF1.11594176
44MAP3K41.10847568
45VRK11.10628794
46STK31.05358478
47TEC1.02341769
48IRAK41.01642559
49NUAK11.01142107
50CDK80.98895383
51ERBB30.96920972
52CAMKK20.93870369
53MST40.91773541
54CSNK1G20.91674626
55EPHA20.89625982
56NEK60.89356698
57ARAF0.87536159
58TNIK0.86392829
59PTK2B0.84587722
60UHMK10.84300713
61ERBB40.84271659
62EPHA30.83513490
63PTK20.82764770
64PRKCE0.82741211
65PHKG10.82169448
66PHKG20.82169448
67MYLK0.80236904
68NEK10.76283629
69LIMK10.76270252
70MAPKAPK50.76173990
71PRKG20.75233150
72PRKCG0.74846039
73MKNK10.73079983
74MAP2K60.72197510
75PAK30.71373706
76STK390.71087918
77BUB10.70403999
78CSNK1A1L0.70288835
79ADRBK20.68417065
80PRKCI0.66343275
81DAPK20.66044116
82MAP2K20.63402573
83MST1R0.61889116
84CAMK2D0.61821254
85FGFR30.60961493
86IGF1R0.60662844
87FER0.59173334
88PDK20.58726758
89NLK0.58055165
90ITK0.57552607
91EIF2AK20.57198498
92ADRBK10.57134614
93KDR0.56861733
94ZAP700.56741749
95PTK60.53682479
96TXK0.52885019
97PBK0.51833738
98STK240.51595165
99NEK90.51099212
100OXSR10.50715504
101DAPK10.50347443
102SCYL20.49407484
103TSSK60.49279044
104IKBKB0.48776454
105PLK10.47408966
106CAMK2B0.47174330
107CASK0.46653091
108PRKAA20.46518426
109GRK50.44339712
110PLK30.43684396
111MAPKAPK30.43432762
112GRK10.43352340
113DYRK1A0.41927647
114PRKCH0.41159415
115JAK30.39949264
116WEE10.39772378
117RPS6KB10.39546180
118PLK20.39090847
119MAP3K10.38733092
120MELK0.38044024
121GSK3A0.37870806
122ILK0.37649348
123CSNK1G30.37546912
124MUSK0.37479467
125PDK30.36320099
126PDK40.36320099
127MAP2K70.34096521
128CSNK1A10.33174010
129DYRK30.32757604
130MAPK130.32665311
131CDC42BPA0.32539581
132PRKAA10.32390961
133MOS0.32233248
134PRKACA0.32059548
135SGK2230.31967941
136SGK4940.31967941
137CAMK2A0.31048653
138TLK10.30540545
139DYRK20.29548405
140TTK0.29448113
141PRKG10.29357016
142DYRK1B0.29309502
143TIE10.28780060
144MAP2K10.28726093
145CSNK1G10.28539926

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030607.43671423
2Maturity onset diabetes of the young_Homo sapiens_hsa049506.77964106
3Sulfur metabolism_Homo sapiens_hsa009204.33278732
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.26122554
5Vibrio cholerae infection_Homo sapiens_hsa051102.42748794
6N-Glycan biosynthesis_Homo sapiens_hsa005102.24857032
7Folate biosynthesis_Homo sapiens_hsa007901.93171498
8SNARE interactions in vesicular transport_Homo sapiens_hsa041301.83744200
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77055037
10Insulin secretion_Homo sapiens_hsa049111.74299034
11Nitrogen metabolism_Homo sapiens_hsa009101.69443299
12Fatty acid elongation_Homo sapiens_hsa000621.66308791
13Oxidative phosphorylation_Homo sapiens_hsa001901.61704249
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61472775
15Selenocompound metabolism_Homo sapiens_hsa004501.59110975
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56011956
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55785709
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44684582
19Vitamin B6 metabolism_Homo sapiens_hsa007501.44004359
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37362233
21Regulation of autophagy_Homo sapiens_hsa041401.34026771
22Other glycan degradation_Homo sapiens_hsa005111.32284752
23Galactose metabolism_Homo sapiens_hsa000521.27905425
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25758556
25Tryptophan metabolism_Homo sapiens_hsa003801.25198738
26Lysosome_Homo sapiens_hsa041421.25119565
27Non-homologous end-joining_Homo sapiens_hsa034501.24809189
28RNA degradation_Homo sapiens_hsa030181.24143788
29Phototransduction_Homo sapiens_hsa047441.20675531
30Butanoate metabolism_Homo sapiens_hsa006501.20085412
31Homologous recombination_Homo sapiens_hsa034401.19098810
32Linoleic acid metabolism_Homo sapiens_hsa005911.17678240
33Collecting duct acid secretion_Homo sapiens_hsa049661.17154007
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16597288
35Sphingolipid metabolism_Homo sapiens_hsa006001.15568418
36Type I diabetes mellitus_Homo sapiens_hsa049401.11520168
37Histidine metabolism_Homo sapiens_hsa003401.11157527
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10902075
39Starch and sucrose metabolism_Homo sapiens_hsa005001.10008383
40Peroxisome_Homo sapiens_hsa041461.02246930
41Parkinsons disease_Homo sapiens_hsa050121.01644640
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01482736
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01131854
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00143913
45Tyrosine metabolism_Homo sapiens_hsa003500.99730697
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97651625
47Mineral absorption_Homo sapiens_hsa049780.96086445
48Phenylalanine metabolism_Homo sapiens_hsa003600.93528559
49Propanoate metabolism_Homo sapiens_hsa006400.93519257
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93462923
51Steroid biosynthesis_Homo sapiens_hsa001000.92583098
52Fatty acid degradation_Homo sapiens_hsa000710.91259937
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87986207
54One carbon pool by folate_Homo sapiens_hsa006700.86008128
55Caffeine metabolism_Homo sapiens_hsa002320.85792308
56Arachidonic acid metabolism_Homo sapiens_hsa005900.84418963
57Ether lipid metabolism_Homo sapiens_hsa005650.81965914
58Cocaine addiction_Homo sapiens_hsa050300.79924392
59Proteasome_Homo sapiens_hsa030500.78370419
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.77344024
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76860606
62Alzheimers disease_Homo sapiens_hsa050100.76748474
63Pyruvate metabolism_Homo sapiens_hsa006200.74286583
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74053972
65Protein digestion and absorption_Homo sapiens_hsa049740.73857347
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71082850
67Metabolic pathways_Homo sapiens_hsa011000.71073909
68Fatty acid metabolism_Homo sapiens_hsa012120.70260980
69Pancreatic secretion_Homo sapiens_hsa049720.69196677
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68890662
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67460691
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67373847
73Glycerolipid metabolism_Homo sapiens_hsa005610.66230827
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64547416
75Fat digestion and absorption_Homo sapiens_hsa049750.64186546
76Fructose and mannose metabolism_Homo sapiens_hsa000510.61960396
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60780855
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59144086
79Circadian rhythm_Homo sapiens_hsa047100.59126085
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58963966
81Thyroid hormone synthesis_Homo sapiens_hsa049180.58184193
82Arginine and proline metabolism_Homo sapiens_hsa003300.56124291
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55161840
84p53 signaling pathway_Homo sapiens_hsa041150.55161818
85Fanconi anemia pathway_Homo sapiens_hsa034600.54206736
86Huntingtons disease_Homo sapiens_hsa050160.53898928
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53629800
88Phagosome_Homo sapiens_hsa041450.53602438
89TGF-beta signaling pathway_Homo sapiens_hsa043500.52330801
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.51645919
91Vitamin digestion and absorption_Homo sapiens_hsa049770.50798018
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48772607
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46892676
94Nucleotide excision repair_Homo sapiens_hsa034200.45506913
95Rheumatoid arthritis_Homo sapiens_hsa053230.45207060
96Renin-angiotensin system_Homo sapiens_hsa046140.44786669
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44237000
98Type II diabetes mellitus_Homo sapiens_hsa049300.44203211
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43428373
100GABAergic synapse_Homo sapiens_hsa047270.42198366
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39921529
102Salivary secretion_Homo sapiens_hsa049700.39670713
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39510794
104beta-Alanine metabolism_Homo sapiens_hsa004100.39390439
105Glutathione metabolism_Homo sapiens_hsa004800.39209002
106Olfactory transduction_Homo sapiens_hsa047400.37580993
107Legionellosis_Homo sapiens_hsa051340.36665154
108RNA transport_Homo sapiens_hsa030130.36514034
109ABC transporters_Homo sapiens_hsa020100.31510869
110Chemical carcinogenesis_Homo sapiens_hsa052040.31292717
111Glucagon signaling pathway_Homo sapiens_hsa049220.30723045
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30013061
113Basal transcription factors_Homo sapiens_hsa030220.29993493
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.27574480
115RNA polymerase_Homo sapiens_hsa030200.25935031
116Retinol metabolism_Homo sapiens_hsa008300.25428192
117Prion diseases_Homo sapiens_hsa050200.24627881
118Purine metabolism_Homo sapiens_hsa002300.24469088
119Amphetamine addiction_Homo sapiens_hsa050310.24377739
120Serotonergic synapse_Homo sapiens_hsa047260.24296424
121Pyrimidine metabolism_Homo sapiens_hsa002400.23466133
122Antigen processing and presentation_Homo sapiens_hsa046120.22425880
123Synaptic vesicle cycle_Homo sapiens_hsa047210.22061482
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21285829
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.21142944
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.20316065
127Ovarian steroidogenesis_Homo sapiens_hsa049130.19931894
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18341494

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