ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	8.16935602
2	hormone catabolic process (GO:0042447)	8.03065810
3	tachykinin receptor signaling pathway (GO:0007217)	7.51989857
4	negative regulation of heart rate (GO:0010459)	6.74042281
5	thyroid hormone generation (GO:0006590)	6.50609695
6	positive regulation of digestive system process (GO:0060456)	6.14334659
7	regulation of action potential (GO:0098900)	5.72743713
8	positive regulation of synaptic transmission, GABAergic (GO:0032230)	5.62044471
9	thyroid hormone metabolic process (GO:0042403)	5.49043288
10	somite development (GO:0061053)	5.39412019
11	neuronal action potential propagation (GO:0019227)	5.31248423
12	response to pheromone (GO:0019236)	5.13944523
13	nonmotile primary cilium assembly (GO:0035058)	4.91384076
14	regulation of glucocorticoid secretion (GO:2000849)	4.55050550
15	cellular modified amino acid catabolic process (GO:0042219)	4.42725573
16	positive regulation of steroid hormone secretion (GO:2000833)	4.42048760
17	fatty acid elongation (GO:0030497)	4.40729531
18	retinal ganglion cell axon guidance (GO:0031290)	4.34872070
19	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	4.31982876
20	ectoderm development (GO:0007398)	4.23586328
21	C4-dicarboxylate transport (GO:0015740)	4.15641302
22	negative regulation of axon guidance (GO:1902668)	4.13684594
23	branched-chain amino acid catabolic process (GO:0009083)	4.07038382
24	limb bud formation (GO:0060174)	3.89308303
25	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.89264724
26	negative regulation of heart contraction (GO:0045822)	3.87682075
27	thalamus development (GO:0021794)	3.85702939
28	presynaptic membrane assembly (GO:0097105)	3.84532355
29	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.75351847
30	chaperone-mediated protein complex assembly (GO:0051131)	3.73690228
31	DNA integration (GO:0015074)	3.71344556
32	negative chemotaxis (GO:0050919)	3.67150578
33	embryonic foregut morphogenesis (GO:0048617)	3.62086920
34	regulation of corticosteroid hormone secretion (GO:2000846)	3.51577607
35	photoreceptor cell maintenance (GO:0045494)	3.48878602
36	prostate gland growth (GO:0060736)	3.37172756
37	positive regulation of renal sodium excretion (GO:0035815)	3.23880738
38	lung-associated mesenchyme development (GO:0060484)	3.20766265
39	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.12591337
40	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.11915512
41	cell proliferation involved in kidney development (GO:0072111)	3.11669585
42	presynaptic membrane organization (GO:0097090)	3.03981489
43	branched-chain amino acid metabolic process (GO:0009081)	3.02196115
44	intraciliary transport (GO:0042073)	3.01564391
45	protein neddylation (GO:0045116)	3.01142428
46	histone H2A acetylation (GO:0043968)	3.00929984
47	axon extension involved in axon guidance (GO:0048846)	2.99618457
48	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.99618457
49	retinal rod cell development (GO:0046548)	2.96764358
50	negative regulation of blood circulation (GO:1903523)	2.96122545
51	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.92370602
52	platelet dense granule organization (GO:0060155)	2.92065707
53	respiratory chain complex IV assembly (GO:0008535)	2.87363194
54	GTP biosynthetic process (GO:0006183)	2.86651039
55	water-soluble vitamin biosynthetic process (GO:0042364)	2.78528764
56	regulation of synaptic transmission, GABAergic (GO:0032228)	2.78270275
57	protein complex biogenesis (GO:0070271)	2.75003140
58	regulation of mesoderm development (GO:2000380)	2.74430332
59	DNA double-strand break processing (GO:0000729)	2.71259352
60	L-glutamate transport (GO:0015813)	2.69060226
61	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.62885453
62	cell proliferation involved in metanephros development (GO:0072203)	2.50321248
63	branch elongation of an epithelium (GO:0060602)	2.49448077
64	artery development (GO:0060840)	2.49248248
65	acidic amino acid transport (GO:0015800)	2.48233131
66	cranial nerve development (GO:0021545)	2.46544644
67	regulation of isotype switching to IgG isotypes (GO:0048302)	2.43999711
68	nucleobase catabolic process (GO:0046113)	2.43563019
69	neuromuscular synaptic transmission (GO:0007274)	2.43411780
70	auditory behavior (GO:0031223)	2.43341850
71	regulation of cilium movement (GO:0003352)	2.42776477
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.41759479
73	lung lobe morphogenesis (GO:0060463)	2.41418545
74	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.41307625
75	NADH dehydrogenase complex assembly (GO:0010257)	2.41307625
76	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.41307625
77	cytochrome complex assembly (GO:0017004)	2.40950623
78	nucleoside diphosphate phosphorylation (GO:0006165)	2.40046250
79	mitochondrial respiratory chain complex assembly (GO:0033108)	2.39390055
80	spinal cord motor neuron differentiation (GO:0021522)	2.39073069
81	regulation of digestive system process (GO:0044058)	2.38810198
82	regulation of steroid hormone secretion (GO:2000831)	2.36210001
83	astrocyte differentiation (GO:0048708)	2.32260429
84	pyrimidine nucleobase catabolic process (GO:0006208)	2.31647226
85	somite rostral/caudal axis specification (GO:0032525)	2.30908951
86	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.30790920
87	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.30790920
88	regulation of translation, ncRNA-mediated (GO:0045974)	2.30790920
89	lactate metabolic process (GO:0006089)	2.30674743
90	hormone biosynthetic process (GO:0042446)	2.30428475
91	glutamate receptor signaling pathway (GO:0007215)	2.29747604
92	neurotransmitter uptake (GO:0001504)	2.29148178
93	galactose catabolic process (GO:0019388)	2.28042805
94	regulation of axon guidance (GO:1902667)	2.27531487
95	regulation of renal sodium excretion (GO:0035813)	2.26559402
96	detection of calcium ion (GO:0005513)	2.26371235
97	retinal cone cell development (GO:0046549)	2.26236315
98	neurotransmitter biosynthetic process (GO:0042136)	2.26111837
99	signal peptide processing (GO:0006465)	2.24336066
100	phenol-containing compound catabolic process (GO:0019336)	10.8128919

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.34266556
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.32072263
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.29142471
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.99897532
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.89206783
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.82481035
7	EWS_26573619_Chip-Seq_HEK293_Human	2.80295758
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.74889526
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.71614504
10	FUS_26573619_Chip-Seq_HEK293_Human	2.50493351
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.45331347
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.37816939
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34539802
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30586377
15	P300_19829295_ChIP-Seq_ESCs_Human	2.24213955
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10741867
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.06878802
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.01105478
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.01083881
20	ZNF274_21170338_ChIP-Seq_K562_Hela	2.00610695
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.93759210
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.93139530
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92458840
24	VDR_22108803_ChIP-Seq_LS180_Human	1.85821098
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.78616255
26	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.78162803
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72761905
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.70377213
29	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.69661977
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68390511
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.66867053
32	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63428541
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61152687
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60059126
35	AR_25329375_ChIP-Seq_VCAP_Human	1.59808433
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.59359788
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57266626
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52650112
39	STAT3_23295773_ChIP-Seq_U87_Human	1.51204056
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.51034984
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50542993
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50542993
43	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49325864
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47567549
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46052151
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.41634870
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40564687
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40488331
49	TP53_18474530_ChIP-ChIP_U2OS_Human	1.36778732
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35967551
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34730692
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34509387
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33208068
54	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.32968145
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28372136
56	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.27540372
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.27142732
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27142732
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25586503
60	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.24744553
61	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.24181913
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24167958
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.23863062
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.23614694
65	EZH2_22144423_ChIP-Seq_EOC_Human	1.23101943
66	TCF4_23295773_ChIP-Seq_U87_Human	1.22490507
67	P53_22387025_ChIP-Seq_ESCs_Mouse	1.21769252
68	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.21618448
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21154892
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21028428
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20246544
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19878991
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19878991
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16667440
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16645064
76	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.16483798
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16240859
78	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.14184085
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14041481
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13169266
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12943606
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.11913706
83	SOX9_26525672_Chip-Seq_HEART_Mouse	1.10517128
84	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.10086703
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08757885
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08244171
87	P300_18555785_Chip-Seq_ESCs_Mouse	1.07413740
88	AHR_22903824_ChIP-Seq_MCF-7_Human	1.06169169
89	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.05321738
90	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.03559941
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03486656
92	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.01515166
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01509450
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00928884
95	JUN_21703547_ChIP-Seq_K562_Human	1.00767531
96	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.00702370
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00443184
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00295476
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99587059
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99187694

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010386_abnormal_urinary_bladder	5.56351952
2	MP0003283_abnormal_digestive_organ	4.19442548
3	MP0002234_abnormal_pharynx_morphology	3.74011548
4	MP0002102_abnormal_ear_morphology	3.24977926
5	MP0002736_abnormal_nociception_after	3.07256182
6	MP0003868_abnormal_feces_composition	3.02394209
7	MP0001984_abnormal_olfaction	2.93795379
8	MP0000383_abnormal_hair_follicle	2.45135404
9	MP0003122_maternal_imprinting	2.26447521
10	MP0001968_abnormal_touch/_nociception	2.20319600
11	MP0003195_calcinosis	2.14751450
12	MP0005646_abnormal_pituitary_gland	2.14218234
13	MP0008877_abnormal_DNA_methylation	2.13152246
14	MP0006292_abnormal_olfactory_placode	1.92088677
15	MP0004147_increased_porphyrin_level	1.92079254
16	MP0002272_abnormal_nervous_system	1.89945372
17	MP0006072_abnormal_retinal_apoptosis	1.84452154
18	MP0004859_abnormal_synaptic_plasticity	1.81238760
19	MP0003880_abnormal_central_pattern	1.75173415
20	MP0000569_abnormal_digit_pigmentation	1.74598064
21	MP0004142_abnormal_muscle_tone	1.72186514
22	MP0005367_renal/urinary_system_phenotyp	1.71288081
23	MP0000516_abnormal_urinary_system	1.71288081
24	MP0010678_abnormal_skin_adnexa	1.69591667
25	MP0009053_abnormal_anal_canal	1.67253168
26	MP0001529_abnormal_vocalization	1.66592044
27	MP0008789_abnormal_olfactory_epithelium	1.59762860
28	MP0003119_abnormal_digestive_system	1.57292051
29	MP0005084_abnormal_gallbladder_morpholo	1.56575358
30	MP0001486_abnormal_startle_reflex	1.54511668
31	MP0002233_abnormal_nose_morphology	1.52319345
32	MP0001970_abnormal_pain_threshold	1.49865740
33	MP0001501_abnormal_sleep_pattern	1.48253706
34	MP0003787_abnormal_imprinting	1.47623670
35	MP0009745_abnormal_behavioral_response	1.40129137
36	MP0006276_abnormal_autonomic_nervous	1.38625624
37	MP0005551_abnormal_eye_electrophysiolog	1.38227088
38	MP0003121_genomic_imprinting	1.37329413
39	MP0002751_abnormal_autonomic_nervous	1.36781225
40	MP0005253_abnormal_eye_physiology	1.36571351
41	MP0002572_abnormal_emotion/affect_behav	1.33844937
42	MP0003186_abnormal_redox_activity	1.33792080
43	MP0004885_abnormal_endolymph	1.30771608
44	MP0002282_abnormal_trachea_morphology	1.26817387
45	MP0003656_abnormal_erythrocyte_physiolo	1.25105567
46	MP0001293_anophthalmia	1.24104759
47	MP0001764_abnormal_homeostasis	1.20779628
48	MP0002064_seizures	1.18941939
49	MP0000566_synostosis	1.18375703
50	MP0000427_abnormal_hair_cycle	1.17415488
51	MP0008872_abnormal_physiological_respon	1.15877408
52	MP0000538_abnormal_urinary_bladder	1.15500190
53	MP0001905_abnormal_dopamine_level	1.14800974
54	MP0005499_abnormal_olfactory_system	1.14302968
55	MP0005394_taste/olfaction_phenotype	1.14302968
56	MP0003635_abnormal_synaptic_transmissio	1.11777227
57	MP0002653_abnormal_ependyma_morphology	1.11057016
58	MP0000631_abnormal_neuroendocrine_gland	1.10115939
59	MP0009046_muscle_twitch	1.07184893
60	MP0002063_abnormal_learning/memory/cond	1.04554488
61	MP0002184_abnormal_innervation	1.04146971
62	MP0002733_abnormal_thermal_nociception	1.03386070
63	MP0002735_abnormal_chemical_nociception	0.98605443
64	MP0005423_abnormal_somatic_nervous	0.97539856
65	MP0001756_abnormal_urination	0.95017902
66	MP0002557_abnormal_social/conspecific_i	0.94929039
67	MP0003567_abnormal_fetal_cardiomyocyte	0.90478359
68	MP0003937_abnormal_limbs/digits/tail_de	0.89494931
69	MP0002090_abnormal_vision	0.88603953
70	MP0003938_abnormal_ear_development	0.86564257
71	MP0003755_abnormal_palate_morphology	0.86249521
72	MP0006054_spinal_hemorrhage	0.85508105
73	MP0001963_abnormal_hearing_physiology	0.84988429
74	MP0000049_abnormal_middle_ear	0.83180990
75	MP0008569_lethality_at_weaning	0.82402034
76	MP0002067_abnormal_sensory_capabilities	0.81878845
77	MP0005167_abnormal_blood-brain_barrier	0.80977169
78	MP0000955_abnormal_spinal_cord	0.75604221
79	MP0005332_abnormal_amino_acid	0.75237051
80	MP0005391_vision/eye_phenotype	0.72568510
81	MP0004270_analgesia	0.72379046
82	MP0004133_heterotaxia	0.71961442
83	MP0004924_abnormal_behavior	0.71543159
84	MP0005386_behavior/neurological_phenoty	0.71543159
85	MP0006035_abnormal_mitochondrial_morpho	0.70682574
86	MP0008775_abnormal_heart_ventricle	0.70389511
87	MP0000613_abnormal_salivary_gland	0.67949520
88	MP0008058_abnormal_DNA_repair	0.65596744
89	MP0002752_abnormal_somatic_nervous	0.65361251
90	MP0005195_abnormal_posterior_eye	0.65015917
91	MP0000026_abnormal_inner_ear	0.63334959
92	MP0004019_abnormal_vitamin_homeostasis	0.62396250
93	MP0001485_abnormal_pinna_reflex	0.61827931
94	MP0005636_abnormal_mineral_homeostasis	0.60678207
95	MP0003879_abnormal_hair_cell	0.60669223
96	MP0005248_abnormal_Harderian_gland	0.60105563
97	MP0008995_early_reproductive_senescence	0.58873007
98	MP0000778_abnormal_nervous_system	0.58342407
99	MP0002734_abnormal_mechanical_nocicepti	0.58207670
100	MP0003698_abnormal_male_reproductive	0.56799894

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital primary aphakia (HP:0007707)	4.95898998
2	Gait imbalance (HP:0002141)	4.94105975
3	Medial flaring of the eyebrow (HP:0010747)	4.71187884
4	Nephrogenic diabetes insipidus (HP:0009806)	4.57980559
5	Intestinal atresia (HP:0011100)	3.95504820
6	Poor coordination (HP:0002370)	3.84769159
7	Vaginal atresia (HP:0000148)	3.80530205
8	Genital tract atresia (HP:0001827)	3.67313289
9	Hip dysplasia (HP:0001385)	3.46618256
10	Abnormality of the labia minora (HP:0012880)	3.37292684
11	Increased density of long bones (HP:0006392)	3.11527514
12	Cerebral edema (HP:0002181)	3.06211966
13	Acute encephalopathy (HP:0006846)	3.02668589
14	Broad foot (HP:0001769)	2.93163136
15	Acute necrotizing encephalopathy (HP:0006965)	2.90323578
16	Specific learning disability (HP:0001328)	2.83351706
17	Postaxial hand polydactyly (HP:0001162)	2.76664919
18	Hypomagnesemia (HP:0002917)	2.73574669
19	Hypothermia (HP:0002045)	2.73551482
20	Difficulty running (HP:0009046)	2.71462820
21	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.67773379
22	Methylmalonic acidemia (HP:0002912)	2.66165268
23	Large for gestational age (HP:0001520)	2.65678929
24	Methylmalonic aciduria (HP:0012120)	2.64975899
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.64777951
26	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.59550370
27	Progressive macrocephaly (HP:0004481)	2.56187289
28	Aplasia/Hypoplasia of the lens (HP:0008063)	2.52725111
29	Broad-based gait (HP:0002136)	2.52293254
30	Humeroradial synostosis (HP:0003041)	2.50258112
31	Synostosis involving the elbow (HP:0003938)	2.50258112
32	Sensorimotor neuropathy (HP:0007141)	2.48194893
33	Bilateral microphthalmos (HP:0007633)	2.42873452
34	Abolished electroretinogram (ERG) (HP:0000550)	2.39501308
35	Postaxial foot polydactyly (HP:0001830)	2.38972830
36	Spastic paraparesis (HP:0002313)	2.38410621
37	Decreased testicular size (HP:0008734)	2.37895375
38	Renal cortical cysts (HP:0000803)	2.31050935
39	Ketosis (HP:0001946)	2.30069902
40	Anophthalmia (HP:0000528)	2.27141310
41	Mesomelia (HP:0003027)	2.24439835
42	Rib fusion (HP:0000902)	2.19781184
43	Growth hormone deficiency (HP:0000824)	2.18801477
44	Mitochondrial inheritance (HP:0001427)	2.17705648
45	Left ventricular hypertrophy (HP:0001712)	2.17633654
46	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16703260
47	Increased CSF lactate (HP:0002490)	2.16058752
48	Short foot (HP:0001773)	2.14109348
49	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.13646766
50	Attenuation of retinal blood vessels (HP:0007843)	2.12350767
51	Hyperglycinemia (HP:0002154)	2.10431028
52	Nephronophthisis (HP:0000090)	2.09239731
53	Asthma (HP:0002099)	2.04384717
54	Generalized aminoaciduria (HP:0002909)	1.99979879
55	Chorioretinal atrophy (HP:0000533)	1.99584938
56	Short tibia (HP:0005736)	1.99362492
57	Albinism (HP:0001022)	1.99352733
58	Glycosuria (HP:0003076)	1.97916996
59	Abnormality of urine glucose concentration (HP:0011016)	1.97916996
60	Abnormality of macular pigmentation (HP:0008002)	1.97870466
61	Abnormality of methionine metabolism (HP:0010901)	1.97020749
62	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.94957310
63	Preaxial hand polydactyly (HP:0001177)	1.94181311
64	Calf muscle hypertrophy (HP:0008981)	1.93682701
65	Abnormal ciliary motility (HP:0012262)	1.92836556
66	Renal hypoplasia (HP:0000089)	1.92173331
67	Gastrointestinal atresia (HP:0002589)	1.92135516
68	Abnormality of magnesium homeostasis (HP:0004921)	1.85420829
69	Abnormal respiratory epithelium morphology (HP:0012253)	1.84219290
70	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84219290
71	Abnormality of the renal cortex (HP:0011035)	1.84153193
72	Bifid tongue (HP:0010297)	1.83279772
73	Pancreatic cysts (HP:0001737)	1.83201913
74	Colon cancer (HP:0003003)	1.83097562
75	Pancreatic islet-cell hyperplasia (HP:0004510)	1.83072908
76	Muscle hypertrophy of the lower extremities (HP:0008968)	1.82391841
77	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.81228445
78	Optic disc pallor (HP:0000543)	1.81192229
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80026887
80	Absent/shortened dynein arms (HP:0200106)	1.80026887
81	Dental crowding (HP:0000678)	1.79494238
82	Adrenal hypoplasia (HP:0000835)	1.77571780
83	Lethargy (HP:0001254)	1.75325456
84	Increased hepatocellular lipid droplets (HP:0006565)	1.75026138
85	Hepatic necrosis (HP:0002605)	1.73874977
86	Hemiparesis (HP:0001269)	1.73746442
87	Focal motor seizures (HP:0011153)	1.72747389
88	Hypoproteinemia (HP:0003075)	1.72734251
89	Panhypogammaglobulinemia (HP:0003139)	1.71375706
90	Abnormal number of incisors (HP:0011064)	1.71234385
91	True hermaphroditism (HP:0010459)	1.71219992
92	Proximal tubulopathy (HP:0000114)	1.69942167
93	Volvulus (HP:0002580)	1.68521767
94	Termporal pattern (HP:0011008)	1.68092914
95	Insidious onset (HP:0003587)	1.68092914
96	Papillary thyroid carcinoma (HP:0002895)	1.68022814
97	Abnormality of the renal medulla (HP:0100957)	1.67512445
98	Preaxial foot polydactyly (HP:0001841)	1.66155807
99	Retinitis pigmentosa (HP:0000510)	1.65210099
100	Curly hair (HP:0002212)	1.65148779

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.86597782
2	MAP3K4	3.64929759
3	FRK	3.50341279
4	TNIK	3.11327241
5	CASK	2.69090016
6	RPS6KA4	2.51042468
7	NUAK1	2.37439617
8	MAP2K7	2.28396597
9	ACVR1B	2.22126550
10	NTRK3	2.20920982
11	FER	2.20781397
12	AKT3	2.19869699
13	BMPR1B	2.19363957
14	MAPK13	2.08579366
15	DYRK3	2.00835960
16	ERBB3	1.96429198
17	ADRBK2	1.71546634
18	WNK3	1.62688457
19	SRPK1	1.51379483
20	SGK2	1.45784006
21	PRKCE	1.45591278
22	PLK2	1.43633938
23	CSNK1G2	1.37149005
24	EPHA4	1.35348737
25	MAPKAPK3	1.32895951
26	INSRR	1.30436537
27	PLK4	1.28902029
28	PAK3	1.24419855
29	CSNK1A1L	1.24112924
30	BCKDK	1.21770209
31	PINK1	1.18661547
32	GRK1	1.18132692
33	MST4	1.17284105
34	PRKCG	1.15566595
35	CSNK1G1	1.14793385
36	CSNK1G3	1.13253453
37	TRIM28	1.10115107
38	BCR	1.09639234
39	MKNK1	1.09622957
40	FES	1.08458441
41	CAMK2G	1.07698899
42	ZAK	1.00060239
43	BRD4	0.97949776
44	EPHA3	0.95639764
45	SGK223	0.95367411
46	SGK494	0.95367411
47	PLK3	0.93312186
48	DAPK1	0.91046694
49	PNCK	0.90287906
50	DYRK2	0.88685281
51	PKN1	0.82197251
52	CAMK1	0.81803657
53	FLT3	0.78271473
54	STK38L	0.73035856
55	DMPK	0.72197510
56	CSNK1A1	0.71891542
57	CAMK4	0.69026259
58	MKNK2	0.68165255
59	ATR	0.65490456
60	MAP2K4	0.64849380
61	MARK1	0.64619411
62	CDK3	0.64124324
63	CAMK2A	0.62893908
64	ROCK1	0.61117017
65	PRKCZ	0.60504332
66	PRKD1	0.59346095
67	STK24	0.59155842
68	STK39	0.58230981
69	FGFR2	0.58020001
70	PKN2	0.57762855
71	NME1	0.57066501
72	RPS6KA5	0.56517033
73	RAF1	0.56430558
74	TGFBR1	0.55725650
75	CAMK2B	0.55675690
76	NLK	0.54005873
77	ERBB2	0.52341206
78	ATM	0.49312968
79	PRKACA	0.49056153
80	PAK6	0.49002817
81	OXSR1	0.48854322
82	KSR1	0.48480263
83	VRK1	0.48380744
84	PRKACB	0.45722627
85	OBSCN	0.45536243
86	SGK3	0.44705636
87	TNK2	0.42181418
88	PRKG1	0.41818831
89	CAMK2D	0.40995482
90	PRKACG	0.39646825
91	MAP3K12	0.39374332
92	MATK	0.38205403
93	VRK2	0.36106999
94	TEC	0.35251171
95	MYLK	0.33907850
96	TSSK6	0.33481257
97	CHUK	0.33298487
98	TIE1	0.32698255
99	PLK1	0.32339700
100	UHMK1	0.31916026

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Propanoate metabolism_Homo sapiens_hsa00640	3.93453758
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.62310061
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	3.32855943
4	Nicotine addiction_Homo sapiens_hsa05033	3.22267509
5	Protein export_Homo sapiens_hsa03060	2.78494507
6	Proteasome_Homo sapiens_hsa03050	2.40630940
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.34489785
8	Fatty acid elongation_Homo sapiens_hsa00062	2.26244951
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.18990138
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.09288528
11	Tryptophan metabolism_Homo sapiens_hsa00380	1.97947097
12	Steroid biosynthesis_Homo sapiens_hsa00100	1.91424607
13	Regulation of autophagy_Homo sapiens_hsa04140	1.88768222
14	Butanoate metabolism_Homo sapiens_hsa00650	1.84287253
15	RNA polymerase_Homo sapiens_hsa03020	1.83021279
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.74390299
17	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.68930622
18	Homologous recombination_Homo sapiens_hsa03440	1.62389819
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.62117511
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.56967240
21	Cocaine addiction_Homo sapiens_hsa05030	1.47062347
22	Peroxisome_Homo sapiens_hsa04146	1.46723517
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.44430364
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.37072558
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.36141507
26	Taste transduction_Homo sapiens_hsa04742	1.30668254
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30507576
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.30451151
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.29572157
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.24327256
31	Parkinsons disease_Homo sapiens_hsa05012	1.22665307
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.21395741
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.21293838
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16893431
35	Phototransduction_Homo sapiens_hsa04744	1.16148372
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.14604345
37	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.14343292
38	Histidine metabolism_Homo sapiens_hsa00340	1.14152727
39	Circadian entrainment_Homo sapiens_hsa04713	1.04755998
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.03696029
41	Amphetamine addiction_Homo sapiens_hsa05031	1.01858300
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.00177888
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.98738451
44	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.98313993
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97552426
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95989654
47	Huntingtons disease_Homo sapiens_hsa05016	0.92830298
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.89152218
49	RNA degradation_Homo sapiens_hsa03018	0.88940239
50	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.87202493
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.86268590
52	Phenylalanine metabolism_Homo sapiens_hsa00360	0.86085225
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84937436
54	Long-term depression_Homo sapiens_hsa04730	0.84727241
55	Purine metabolism_Homo sapiens_hsa00230	0.80256160
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.79422756
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76915142
58	Insulin secretion_Homo sapiens_hsa04911	0.73020526
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.71770480
60	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.70517551
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69452264
62	Basal transcription factors_Homo sapiens_hsa03022	0.69410169
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67967170
64	Lysine degradation_Homo sapiens_hsa00310	0.67481700
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.66950056
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65934460
67	Nitrogen metabolism_Homo sapiens_hsa00910	0.65146075
68	Folate biosynthesis_Homo sapiens_hsa00790	0.64781538
69	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.63750346
70	Metabolic pathways_Homo sapiens_hsa01100	0.62657156
71	GABAergic synapse_Homo sapiens_hsa04727	0.62316234
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.61673841
73	Retinol metabolism_Homo sapiens_hsa00830	0.61629943
74	Olfactory transduction_Homo sapiens_hsa04740	0.61334967
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57769017
76	Caffeine metabolism_Homo sapiens_hsa00232	0.53048417
77	cAMP signaling pathway_Homo sapiens_hsa04024	0.52783915
78	Glutathione metabolism_Homo sapiens_hsa00480	0.50700231
79	Serotonergic synapse_Homo sapiens_hsa04726	0.50208934
80	Mismatch repair_Homo sapiens_hsa03430	0.44611525
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44355714
82	Sulfur relay system_Homo sapiens_hsa04122	0.44186433
83	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43042063
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.42982522
85	Fatty acid degradation_Homo sapiens_hsa00071	0.42197810
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41306680
87	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.41046068
88	RNA transport_Homo sapiens_hsa03013	0.40955348
89	Salivary secretion_Homo sapiens_hsa04970	0.39824578
90	Circadian rhythm_Homo sapiens_hsa04710	0.39757155
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38791296
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38266589
93	Alzheimers disease_Homo sapiens_hsa05010	0.37779262
94	Type II diabetes mellitus_Homo sapiens_hsa04930	0.36981083
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.35037148
96	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34637953
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34513295
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33444429
99	ABC transporters_Homo sapiens_hsa02010	0.32464852
100	Type I diabetes mellitus_Homo sapiens_hsa04940	0.30508840

TVP23CP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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