TWF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)5.09244538
2negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.87926512
3cell adhesion mediated by integrin (GO:0033627)4.83896495
4desmosome organization (GO:0002934)4.68927343
5hemidesmosome assembly (GO:0031581)4.43248884
6regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.24500199
7signal peptide processing (GO:0006465)4.24481082
8COPII vesicle coating (GO:0048208)4.23606105
9regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)4.19040115
10ganglion development (GO:0061548)4.04559833
11negative regulation of signal transduction by p53 class mediator (GO:1901797)3.95944985
12skin morphogenesis (GO:0043589)3.77441578
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.72217056
14hepatocyte apoptotic process (GO:0097284)3.71927812
15neutrophil activation involved in immune response (GO:0002283)3.64926223
16regulation of dendritic cell antigen processing and presentation (GO:0002604)3.56406773
17protein retention in ER lumen (GO:0006621)3.52377936
18centriole replication (GO:0007099)3.51440881
19vesicle coating (GO:0006901)3.37302850
20protein localization to endosome (GO:0036010)3.31581640
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.28205370
22superoxide anion generation (GO:0042554)3.24886178
23centriole assembly (GO:0098534)3.24496653
24COPI coating of Golgi vesicle (GO:0048205)3.23985711
25Golgi transport vesicle coating (GO:0048200)3.23985711
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22653731
27nuclear pore complex assembly (GO:0051292)3.19207204
28cellular response to gamma radiation (GO:0071480)3.17922570
29intraciliary transport (GO:0042073)3.16802880
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14977678
31notochord development (GO:0030903)3.13866485
32dendritic cell chemotaxis (GO:0002407)3.11848276
33ER overload response (GO:0006983)3.11566953
34neural crest cell development (GO:0014032)3.08321920
35negative regulation of mast cell activation (GO:0033004)3.07758242
36regulation of interleukin-8 secretion (GO:2000482)3.06515497
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04473675
38peptide catabolic process (GO:0043171)3.04035522
39dosage compensation (GO:0007549)3.03127350
40hydrogen peroxide biosynthetic process (GO:0050665)3.01889622
41negative regulation of chondrocyte differentiation (GO:0032331)3.01296533
42UDP-N-acetylglucosamine metabolic process (GO:0006047)3.01147070
43removal of superoxide radicals (GO:0019430)2.99658986
44cellular response to superoxide (GO:0071451)2.99658986
45cellular response to oxygen radical (GO:0071450)2.99658986
46bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99563238
47protein hydroxylation (GO:0018126)2.99312705
48negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.96708745
49neural tube formation (GO:0001841)2.94218418
50production of molecular mediator involved in inflammatory response (GO:0002532)2.93493731
51positive regulation of actin filament depolymerization (GO:0030836)2.92666652
52paraxial mesoderm development (GO:0048339)2.91671091
53regulation of transforming growth factor beta2 production (GO:0032909)2.91577800
54dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.88448072
55myoblast migration (GO:0051451)2.87712872
56nucleotide transmembrane transport (GO:1901679)2.86816277
57ribosome assembly (GO:0042255)2.85364875
58regulation of metalloenzyme activity (GO:0048552)2.85182595
59negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.84713558
60regulation of mitotic spindle organization (GO:0060236)2.83003480
61nuclear pore organization (GO:0006999)2.82894470
62peptidyl-proline hydroxylation (GO:0019511)2.82734809
63epithelial cell-cell adhesion (GO:0090136)2.78234266
64nucleotide-sugar biosynthetic process (GO:0009226)2.77130146
65retina vasculature morphogenesis in camera-type eye (GO:0061299)2.76983747
66midgut development (GO:0007494)2.75276850
67regulation of chemokine secretion (GO:0090196)2.74529976
68mammary gland epithelial cell proliferation (GO:0033598)2.72674740
69reactive oxygen species biosynthetic process (GO:1903409)2.69365998
70cellular response to virus (GO:0098586)2.68925777
71branching involved in mammary gland duct morphogenesis (GO:0060444)2.68885247
72neutrophil activation (GO:0042119)2.66786533
73hippo signaling (GO:0035329)2.66681742
74nucleobase-containing small molecule interconversion (GO:0015949)2.66295680
75regulation of early endosome to late endosome transport (GO:2000641)2.66078768
76phagocytosis, engulfment (GO:0006911)2.65656851
77cellular response to vitamin (GO:0071295)2.64357460
78cellular protein complex localization (GO:0034629)2.64091903
79membrane budding (GO:0006900)2.63987131
80mesodermal cell differentiation (GO:0048333)2.63695769
81intestinal epithelial cell development (GO:0060576)2.63528150
82regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.63423873
83positive regulation of T cell migration (GO:2000406)2.63082221
84natural killer cell mediated immunity (GO:0002228)2.62700297
85natural killer cell mediated cytotoxicity (GO:0042267)2.62700297
86negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.62331305
87keratinocyte proliferation (GO:0043616)2.62258552
88regulation of glucokinase activity (GO:0033131)2.61847938
89regulation of hexokinase activity (GO:1903299)2.61847938
90cellular response to vitamin D (GO:0071305)2.60950158
91negative regulation of anoikis (GO:2000811)2.60683900
92cyclooxygenase pathway (GO:0019371)2.60484806
93iron ion import (GO:0097286)2.59804222
94eosinophil chemotaxis (GO:0048245)2.59675547
95negative regulation of protein localization to plasma membrane (GO:1903077)2.58709386
96positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.58429233
97negative regulation of keratinocyte proliferation (GO:0010839)2.57630213
98positive regulation of monocyte chemotaxis (GO:0090026)2.57176110
99positive regulation of megakaryocyte differentiation (GO:0045654)2.57154430
100myelin assembly (GO:0032288)2.57071503
101dendritic cell migration (GO:0036336)2.56484031
102snRNA transcription (GO:0009301)2.55802529
103regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.55468370
104negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.54925001
105energy homeostasis (GO:0097009)2.54696185
106regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)2.54292771
107poly(A)+ mRNA export from nucleus (GO:0016973)2.54262893
108cornea development in camera-type eye (GO:0061303)2.54130880
109somite development (GO:0061053)2.53224373
110cell-substrate junction assembly (GO:0007044)2.51828270
111bone remodeling (GO:0046849)2.51826926
112membrane protein ectodomain proteolysis (GO:0006509)2.49878290
113sympathetic nervous system development (GO:0048485)2.49637590
114mitotic cytokinesis (GO:0000281)2.49236318
115tight junction assembly (GO:0070830)2.49192772
116regulation of double-strand break repair via homologous recombination (GO:0010569)2.48425930
117regulation of transforming growth factor beta1 production (GO:0032908)2.48141514
118regulation of RIG-I signaling pathway (GO:0039535)2.47445083
119gap junction assembly (GO:0016264)2.47101145
120inner ear receptor cell differentiation (GO:0060113)2.46706384
121cell differentiation involved in metanephros development (GO:0072202)2.45443656
122mitotic sister chromatid cohesion (GO:0007064)2.45210837
123negative regulation of glycogen biosynthetic process (GO:0045719)2.45029117
124regulation of T cell chemotaxis (GO:0010819)2.44082259
125positive regulation of T cell chemotaxis (GO:0010820)2.44082259
126mitochondrial calcium ion transport (GO:0006851)2.44030883
127negative regulation of viral genome replication (GO:0045071)2.43661440
128modulation by virus of host process (GO:0019054)2.43653871
129lipoxygenase pathway (GO:0019372)2.43457654
130inflammatory response to antigenic stimulus (GO:0002437)2.43433986
131chondrocyte proliferation (GO:0035988)2.42278970
132diterpenoid biosynthetic process (GO:0016102)2.41527742
133granulocyte activation (GO:0036230)2.40363746
134cytoskeleton-dependent cytokinesis (GO:0061640)2.40230516
135positive regulation of lymphocyte migration (GO:2000403)2.39102332
136endodermal cell differentiation (GO:0035987)2.38645196
137positive regulation of cellular amide metabolic process (GO:0034250)2.38241057
138regulation of integrin-mediated signaling pathway (GO:2001044)2.37541068
139wound healing, spreading of epidermal cells (GO:0035313)2.37234379
140muscle cell migration (GO:0014812)2.36360301
141regulation of anoikis (GO:2000209)2.35448667
142olfactory bulb development (GO:0021772)2.35107581
143response to peptidoglycan (GO:0032494)2.35031307
144endothelial cell morphogenesis (GO:0001886)2.34283886
145mesenchymal cell development (GO:0014031)2.34180699
146activation of Rac GTPase activity (GO:0032863)2.33461418
147regulation of sister chromatid cohesion (GO:0007063)2.33047083
148collagen fibril organization (GO:0030199)2.32511059
149regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.32222733
150regulation of cardioblast differentiation (GO:0051890)2.32167792
151metanephric mesenchyme development (GO:0072075)2.31995143
152negative regulation of response to DNA damage stimulus (GO:2001021)2.31397407
153positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.31220380
154substrate-dependent cell migration (GO:0006929)2.30681549
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.29645260
156negative regulation of stem cell proliferation (GO:2000647)2.29477523
157eosinophil migration (GO:0072677)2.29474399
158actin filament depolymerization (GO:0030042)2.29463127
159positive regulation of interferon-alpha production (GO:0032727)2.29283886
160regulation of G0 to G1 transition (GO:0070316)2.29260828
161negative regulation of systemic arterial blood pressure (GO:0003085)2.29030568
162hypotonic response (GO:0006971)2.28958834
163positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.28203242
164regulation of protein localization to plasma membrane (GO:1903076)2.27874813
165extracellular negative regulation of signal transduction (GO:1900116)2.26900917
166extracellular regulation of signal transduction (GO:1900115)2.26900917
167Notch signaling involved in heart development (GO:0061314)2.26687785
168modulation by symbiont of host cellular process (GO:0044068)2.26547878
169response to superoxide (GO:0000303)2.26229215
170protein localization to microtubule (GO:0035372)2.26174629
171regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.25504596
172hepatocyte differentiation (GO:0070365)2.25500537
173ER to Golgi vesicle-mediated transport (GO:0006888)2.25462141
174proline biosynthetic process (GO:0006561)2.25386311
175regulation of spindle organization (GO:0090224)2.24602373
176pore complex assembly (GO:0046931)2.23829711
177positive regulation of glycoprotein metabolic process (GO:1903020)2.23590490
178membrane raft organization (GO:0031579)2.23511883
179cell-cell junction assembly (GO:0007043)2.23026407
180endoplasmic reticulum unfolded protein response (GO:0030968)2.22692477
181protein heterotetramerization (GO:0051290)2.22309669
182activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.21374146
183regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.20546764
184regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.20518845
185protein N-linked glycosylation via asparagine (GO:0018279)2.20446090
186positive regulation of protein localization to plasma membrane (GO:1903078)2.20188858
187mitotic chromosome condensation (GO:0007076)2.19281467
188peptidyl-asparagine modification (GO:0018196)2.18211655
189ER-nucleus signaling pathway (GO:0006984)2.18036132
190protein complex localization (GO:0031503)2.16495586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.85026802
2AR_21909140_ChIP-Seq_LNCAP_Human3.73116178
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.23824940
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.17583574
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.09003239
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.06484271
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98252227
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.78597878
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71417720
10CLOCK_20551151_ChIP-Seq_293T_Human2.66632480
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62541555
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.58234183
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56403647
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.38883736
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36977202
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.32920301
17ZNF263_19887448_ChIP-Seq_K562_Human2.31787997
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.22871445
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.21671062
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15783799
21ELK1_19687146_ChIP-ChIP_HELA_Human1.99889363
22* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96600563
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96027580
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94885777
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94244356
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.92056612
27FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.91377523
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.90643466
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.90441611
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.87629091
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86512711
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85835865
33CJUN_26792858_Chip-Seq_BT549_Human1.81678027
34VDR_22108803_ChIP-Seq_LS180_Human1.80437756
35EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.75335636
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74875912
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.71444416
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.67064099
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65497294
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64277993
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63881296
42SOX2_20726797_ChIP-Seq_SW620_Human1.63344518
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63105843
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61773165
45* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60381099
46* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60381099
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.59267529
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57195338
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57127569
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55832436
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.55696791
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.55436991
53* FOXO3_23340844_ChIP-Seq_DLD1_Human1.53678595
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51989932
55E2F7_22180533_ChIP-Seq_HELA_Human1.51988419
56IGF1R_20145208_ChIP-Seq_DFB_Human1.50096961
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.49607842
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48875577
59* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.47158546
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46884394
61ATF3_27146783_Chip-Seq_COLON_Human1.43461271
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42788957
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41194377
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.41169238
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40947913
66GATA6_25053715_ChIP-Seq_YYC3_Human1.40466813
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.39169623
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37935951
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36752226
70GATA3_24758297_ChIP-Seq_MCF-7_Human1.35154579
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.33133995
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31878468
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31205755
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31187885
75BRD4_25478319_ChIP-Seq_HGPS_Human1.30645342
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29856055
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.29491059
78CHD1_26751641_Chip-Seq_LNCaP_Human1.29411880
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29336815
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28125405
81TFEB_21752829_ChIP-Seq_HELA_Human1.27975531
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27757291
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27527538
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27090860
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26646113
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25281122
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25281122
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25227738
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25064073
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24656646
91GATA4_25053715_ChIP-Seq_YYC3_Human1.23910391
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23237625
93TP53_18474530_ChIP-ChIP_U2OS_Human1.22968834
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22880483
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22625257
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.22218428
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.22151904
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21780150
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21736797
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20817219
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.20432602
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20347649
103DCP1A_22483619_ChIP-Seq_HELA_Human1.19388365
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.19311194
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19166614
106P53_22387025_ChIP-Seq_ESCs_Mouse1.18865527
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18847643
108MYC_18555785_ChIP-Seq_MESCs_Mouse1.18568667
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18053260
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17943440
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17116981
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16655141
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.16118147
114ELF5_23300383_ChIP-Seq_T47D_Human1.15209447
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13647391
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11021045
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10558361
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09885543
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08840193
120GF1B_26923725_Chip-Seq_HPCs_Mouse1.08060648
121NMYC_18555785_Chip-Seq_ESCs_Mouse1.07909938
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07711111
123AHR_22903824_ChIP-Seq_MCF-7_Human1.07700784
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.07286948
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05940528
126P300_18555785_Chip-Seq_ESCs_Mouse1.05811677
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05665001
128ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04051188
129ZFX_18555785_Chip-Seq_ESCs_Mouse1.03258337
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02560377
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02456329
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00955740
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.00696834
134* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00653472
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00632884
136P300_19829295_ChIP-Seq_ESCs_Human1.00411117
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99576837
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98910276
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.98816962
140* TP63_23658742_ChIP-Seq_EP156T_Human0.98487521
141TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97622330
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97399848
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97182524
144PU1_27457419_Chip-Seq_LIVER_Mouse0.96369530
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.96078125
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95787339
147* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.95469648
148FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94598319
149ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94216653
150RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93280109
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93096394
152ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92974357
153ELK1_22589737_ChIP-Seq_MCF10A_Human0.92126631
154SOX2_18555785_Chip-Seq_ESCs_Mouse0.92039288
155* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92026243
156PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91860872
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90842113
158GATA2_21666600_ChIP-Seq_HMVEC_Human0.90756329
159CDX2_22108803_ChIP-Seq_LS180_Human0.90693739
160TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90583845
161STAT1_17558387_ChIP-Seq_HELA_Human0.90449562
162TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90372465
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89797617
164ER_23166858_ChIP-Seq_MCF-7_Human0.89623412
165SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89276981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.66068059
2MP0008789_abnormal_olfactory_epithelium3.91882828
3MP0010352_gastrointestinal_tract_polyps3.66996421
4MP0002877_abnormal_melanocyte_morpholog3.65519327
5MP0003787_abnormal_imprinting3.44211874
6MP0009780_abnormal_chondrocyte_physiolo3.15036842
7MP0003705_abnormal_hypodermis_morpholog3.11542119
8MP0008438_abnormal_cutaneous_collagen3.01334516
9MP0005499_abnormal_olfactory_system2.89057059
10MP0005394_taste/olfaction_phenotype2.89057059
11MP0005503_abnormal_tendon_morphology2.79996432
12MP0005171_absent_coat_pigmentation2.57525827
13MP0004782_abnormal_surfactant_physiolog2.50739305
14MP0005257_abnormal_intraocular_pressure2.50002543
15MP0008007_abnormal_cellular_replicative2.31667862
16MP0010678_abnormal_skin_adnexa2.27033344
17MP0003950_abnormal_plasma_membrane2.14122030
18MP0002148_abnormal_hypersensitivity_rea2.08105072
19MP0002876_abnormal_thyroid_physiology2.06424554
20MP0006054_spinal_hemorrhage2.05084433
21MP0002796_impaired_skin_barrier2.02119056
22MP0009697_abnormal_copulation1.92943934
23MP0000537_abnormal_urethra_morphology1.92027230
24MP0001542_abnormal_bone_strength1.90154496
25MP0010030_abnormal_orbit_morphology1.89140482
26MP0005408_hypopigmentation1.85700283
27MP0005623_abnormal_meninges_morphology1.84343756
28MP0010386_abnormal_urinary_bladder1.82698065
29MP0002009_preneoplasia1.80425739
30MP0002160_abnormal_reproductive_system1.78646613
31MP0003186_abnormal_redox_activity1.78166566
32MP0003195_calcinosis1.75929429
33MP0005275_abnormal_skin_tensile1.72758423
34MP0003941_abnormal_skin_development1.71308340
35MP0000516_abnormal_urinary_system1.63772597
36MP0005367_renal/urinary_system_phenotyp1.63772597
37MP0008877_abnormal_DNA_methylation1.63363562
38MP0000566_synostosis1.62123184
39MP0005501_abnormal_skin_physiology1.62081227
40MP0000762_abnormal_tongue_morphology1.61916866
41MP0003091_abnormal_cell_migration1.61239438
42MP0000372_irregular_coat_pigmentation1.56748473
43MP0008058_abnormal_DNA_repair1.56653967
44MP0003191_abnormal_cellular_cholesterol1.56294688
45MP0003878_abnormal_ear_physiology1.53633555
46MP0005377_hearing/vestibular/ear_phenot1.53633555
47MP0002896_abnormal_bone_mineralization1.53451351
48MP0005023_abnormal_wound_healing1.50154939
49MP0001835_abnormal_antigen_presentation1.49565574
50MP0005645_abnormal_hypothalamus_physiol1.46082984
51MP0003453_abnormal_keratinocyte_physiol1.42725093
52MP0004134_abnormal_chest_morphology1.41756234
53MP0005409_darkened_coat_color1.40493329
54MP0000579_abnormal_nail_morphology1.38821429
55MP0001346_abnormal_lacrimal_gland1.35276593
56MP0000049_abnormal_middle_ear1.34963978
57MP0003279_aneurysm1.33357838
58MP0001216_abnormal_epidermal_layer1.33222885
59MP0005360_urolithiasis1.32736835
60MP0009053_abnormal_anal_canal1.32300233
61MP0002163_abnormal_gland_morphology1.31046469
62MP0003121_genomic_imprinting1.30378046
63MP0002233_abnormal_nose_morphology1.29374997
64MP0002098_abnormal_vibrissa_morphology1.28103555
65MP0002277_abnormal_respiratory_mucosa1.26572382
66MP0005508_abnormal_skeleton_morphology1.26162024
67MP0001177_atelectasis1.25455976
68MP0004957_abnormal_blastocyst_morpholog1.24740960
69MP0005248_abnormal_Harderian_gland1.23028119
70MP0000383_abnormal_hair_follicle1.22802768
71MP0009250_abnormal_appendicular_skeleto1.22015920
72MP0002751_abnormal_autonomic_nervous1.21020273
73MP0000627_abnormal_mammary_gland1.19896461
74MP0000427_abnormal_hair_cycle1.19872340
75MP0000467_abnormal_esophagus_morphology1.19836468
76MP0003868_abnormal_feces_composition1.19779463
77MP0000538_abnormal_urinary_bladder1.19759641
78MP0005197_abnormal_uvea_morphology1.17565264
79MP0005389_reproductive_system_phenotype1.16717431
80MP0004233_abnormal_muscle_weight1.16460162
81MP0005084_abnormal_gallbladder_morpholo1.15480615
82MP0003943_abnormal_hepatobiliary_system1.11920546
83MP0000377_abnormal_hair_follicle1.11461125
84MP0000013_abnormal_adipose_tissue1.10262645
85MP0009785_altered_susceptibility_to1.09664979
86MP0001119_abnormal_female_reproductive1.06220942
87MP0000678_abnormal_parathyroid_gland1.04279170
88MP0001243_abnormal_dermal_layer1.04205475
89MP0003806_abnormal_nucleotide_metabolis1.04156095
90MP0001188_hyperpigmentation1.03813640
91MP0001849_ear_inflammation1.02854609
92MP0002132_abnormal_respiratory_system1.02621211
93MP0005390_skeleton_phenotype1.02382657
94MP0001299_abnormal_eye_distance/1.01932682
95MP0001984_abnormal_olfaction1.01232153
96MP0003786_premature_aging1.00357209
97MP0000462_abnormal_digestive_system0.99974455
98MP0010771_integument_phenotype0.99661939
99MP0008932_abnormal_embryonic_tissue0.98836201
100MP0001324_abnormal_eye_pigmentation0.96997610
101MP0006292_abnormal_olfactory_placode0.96710619
102MP0000015_abnormal_ear_pigmentation0.96026824
103MP0002938_white_spotting0.95221137
104MP0002295_abnormal_pulmonary_circulatio0.94777685
105MP0002060_abnormal_skin_morphology0.94203003
106MP0009840_abnormal_foam_cell0.93259835
107MP0005076_abnormal_cell_differentiation0.93051818
108MP0001186_pigmentation_phenotype0.93050357
109MP0000733_abnormal_muscle_development0.92982344
110MP0010368_abnormal_lymphatic_system0.91035279
111MP0000003_abnormal_adipose_tissue0.90526859
112MP0000163_abnormal_cartilage_morphology0.90356233
113MP0002115_abnormal_skeleton_extremities0.89105191
114MP0000681_abnormal_thyroid_gland0.88389339
115MP0003755_abnormal_palate_morphology0.88366809
116MP0000534_abnormal_ureter_morphology0.88335270
117MP0001286_abnormal_eye_development0.88259337
118MP0010307_abnormal_tumor_latency0.88186953
119MP0009384_cardiac_valve_regurgitation0.87887381
120MP0002697_abnormal_eye_size0.86925424
121MP0001986_abnormal_taste_sensitivity0.86339178
122MP0001666_abnormal_nutrient_absorption0.86099833
123MP0000647_abnormal_sebaceous_gland0.84846141
124MP0000767_abnormal_smooth_muscle0.84799590
125MP0005085_abnormal_gallbladder_physiolo0.82591269
126MP0005187_abnormal_penis_morphology0.82581492
127MP0004264_abnormal_extraembryonic_tissu0.82549273
128MP0004185_abnormal_adipocyte_glucose0.82495039
129MP0003942_abnormal_urinary_system0.81913753
130MP0001881_abnormal_mammary_gland0.81080952
131MP0001958_emphysema0.80977777
132MP0002084_abnormal_developmental_patter0.80961897
133MP0003385_abnormal_body_wall0.80885791
134MP0002092_abnormal_eye_morphology0.80417715
135MP0003077_abnormal_cell_cycle0.80257983
136MP0000613_abnormal_salivary_gland0.79567239
137MP0002086_abnormal_extraembryonic_tissu0.78983124
138MP0000371_diluted_coat_color0.78601856
139MP0005621_abnormal_cell_physiology0.78522752
140MP0004272_abnormal_basement_membrane0.77931271
141MP0000350_abnormal_cell_proliferation0.77892422
142MP0002419_abnormal_innate_immunity0.77773553
143MP0005310_abnormal_salivary_gland0.77686083
144MP0000432_abnormal_head_morphology0.77659620
145MP0005379_endocrine/exocrine_gland_phen0.76982326
146MP0002138_abnormal_hepatobiliary_system0.76367223
147MP0003183_abnormal_peptide_metabolism0.76243701
148MP0001533_abnormal_skeleton_physiology0.76203045
149MP0004133_heterotaxia0.75826810
150MP0001879_abnormal_lymphatic_vessel0.75801607
151MP0003566_abnormal_cell_adhesion0.75460598
152MP0001730_embryonic_growth_arrest0.75026265
153MP0003436_decreased_susceptibility_to0.74879168
154MP0000858_altered_metastatic_potential0.73968220
155MP0005193_abnormal_anterior_eye0.73898040
156MP0003724_increased_susceptibility_to0.73840629
157MP0002168_other_aberrant_phenotype0.73473325
158MP0002006_tumorigenesis0.73429101
159MP0001175_abnormal_lung_morphology0.73384393
160MP0003795_abnormal_bone_structure0.73210617
161MP0003693_abnormal_embryo_hatching0.72959948
162MP0001672_abnormal_embryogenesis/_devel0.71969945
163MP0005380_embryogenesis_phenotype0.71969945
164MP0001915_intracranial_hemorrhage0.70853950
165MP0003937_abnormal_limbs/digits/tail_de0.70367406
166MP0005165_increased_susceptibility_to0.68639308
167MP0008057_abnormal_DNA_replication0.67920647
168MP0003984_embryonic_growth_retardation0.67095297
169MP0002088_abnormal_embryonic_growth/wei0.64621029
170MP0001697_abnormal_embryo_size0.64532130
171MP0003315_abnormal_perineum_morphology0.64304377
172MP0004858_abnormal_nervous_system0.64254528

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.71213703
2Hypothermia (HP:0002045)4.10805202
3Syringomyelia (HP:0003396)3.98408219
4Spinal cord lesions (HP:0100561)3.98408219
5Protrusio acetabuli (HP:0003179)3.78526506
6Asymmetry of the thorax (HP:0001555)3.71339924
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.47791645
8Osteolytic defects of the hand bones (HP:0009699)3.47791645
9True hermaphroditism (HP:0010459)3.40056310
10Arterial tortuosity (HP:0005116)3.30333208
11Vascular tortuosity (HP:0004948)3.22896003
12Atrophic scars (HP:0001075)3.17923795
13Abnormality of the anterior horn cell (HP:0006802)3.11062730
14Degeneration of anterior horn cells (HP:0002398)3.11062730
15Pancreatic fibrosis (HP:0100732)3.04940173
16Cervical subluxation (HP:0003308)2.88970569
17Ankle contracture (HP:0006466)2.87381946
18Cardiovascular calcification (HP:0011915)2.86046877
19Abnormality of dentin (HP:0010299)2.81296528
20Palpebral edema (HP:0100540)2.78945314
21Short nail (HP:0001799)2.69602227
22Termporal pattern (HP:0011008)2.65059796
23Insidious onset (HP:0003587)2.65059796
24Vertebral compression fractures (HP:0002953)2.61369605
25Vascular calcification (HP:0004934)2.59313738
26Thyroid carcinoma (HP:0002890)2.59000919
27Aortic dissection (HP:0002647)2.58493851
28Right ventricular cardiomyopathy (HP:0011663)2.57600260
29Mitral stenosis (HP:0001718)2.55102672
30Follicular hyperkeratosis (HP:0007502)2.52681128
31Xerostomia (HP:0000217)2.52290613
32Occipital encephalocele (HP:0002085)2.50561070
33Abnormality of the intervertebral disk (HP:0005108)2.48654506
34Adrenal hypoplasia (HP:0000835)2.44685842
35Osteomalacia (HP:0002749)2.44179054
36Curly hair (HP:0002212)2.41555569
37Mesomelia (HP:0003027)2.38285727
38Median cleft lip (HP:0000161)2.35801048
39Alveolar cell carcinoma (HP:0006519)2.35718832
40Lip pit (HP:0100267)2.35035837
41Deep philtrum (HP:0002002)2.32411252
42Ankyloglossia (HP:0010296)2.30528232
43Cystic hygroma (HP:0000476)2.30197663
44Microglossia (HP:0000171)2.28921813
45Conjugated hyperbilirubinemia (HP:0002908)2.27896280
46Papillary thyroid carcinoma (HP:0002895)2.25789010
47Flat acetabular roof (HP:0003180)2.25246828
48Fragile skin (HP:0001030)2.24700465
49Natal tooth (HP:0000695)2.24387894
50Pancreatic cysts (HP:0001737)2.23954425
51Pulmonary artery stenosis (HP:0004415)2.19061873
52Tetraparesis (HP:0002273)2.15890371
53Medial flaring of the eyebrow (HP:0010747)2.15331015
54Abnormality of oral frenula (HP:0000190)2.14797878
55Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.14461646
56Facial cleft (HP:0002006)2.14441102
57Onycholysis (HP:0001806)2.13762171
58Postaxial foot polydactyly (HP:0001830)2.13104071
59Pterygium (HP:0001059)2.11632533
60Pili torti (HP:0003777)2.10520019
61Abnormality of incisor morphology (HP:0011063)2.10163198
62Type I transferrin isoform profile (HP:0003642)2.10060261
63Patchy hypopigmentation of hair (HP:0011365)2.09463690
64Subacute progressive viral hepatitis (HP:0006572)2.08803314
65White forelock (HP:0002211)2.08501618
66Cutaneous melanoma (HP:0012056)2.08257449
67Alopecia of scalp (HP:0002293)2.07707979
68Abnormal auditory evoked potentials (HP:0006958)2.07282096
69Abnormality of the frontal sinuses (HP:0002687)2.07163588
70Prostate neoplasm (HP:0100787)2.07066640
71Vacuolated lymphocytes (HP:0001922)2.06491990
72Abnormality of the distal phalanges of the toes (HP:0010182)2.06096934
73Nephrogenic diabetes insipidus (HP:0009806)2.05746737
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.05221758
75Hypoplasia of the fovea (HP:0007750)2.05221758
76Intrahepatic cholestasis (HP:0001406)2.03246079
77Systemic lupus erythematosus (HP:0002725)2.02998098
78Epiphyseal dysplasia (HP:0002656)2.02694919
79Congenital primary aphakia (HP:0007707)2.02032766
80Congenital sensorineural hearing impairment (HP:0008527)2.01892453
81Elbow flexion contracture (HP:0002987)2.01094483
82Beaking of vertebral bodies (HP:0004568)2.01043036
83Ulnar bowing (HP:0003031)2.00593245
84Abnormality of the umbilical cord (HP:0010881)2.00125516
85Abnormality of the acetabulum (HP:0003170)1.99895261
86Wormian bones (HP:0002645)1.98560903
87Prolonged neonatal jaundice (HP:0006579)1.98484723
88Slow-growing hair (HP:0002217)1.98204065
89Abnormality of hair growth rate (HP:0011363)1.98204065
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.95906074
91Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95427877
92Neoplasm of the tracheobronchial system (HP:0100552)1.95053935
93Preaxial hand polydactyly (HP:0001177)1.94980430
94Abnormality of nail color (HP:0100643)1.94226960
95Bladder diverticulum (HP:0000015)1.94176322
96Progressive sensorineural hearing impairment (HP:0000408)1.94108097
97Plantar hyperkeratosis (HP:0007556)1.93193215
98Spinal cord compression (HP:0002176)1.93071192
99Abnormality of the fetal cardiovascular system (HP:0010948)1.90449294
100Abnormal umbilical cord blood vessels (HP:0011403)1.90449294
101Single umbilical artery (HP:0001195)1.90449294
102Hypoplastic scapulae (HP:0000882)1.89903574
103Aplasia/Hypoplasia of the scapulae (HP:0006713)1.89903574
104Renal tubular acidosis (HP:0001947)1.89063898
105Tongue fasciculations (HP:0001308)1.88955510
106Absent eyebrow (HP:0002223)1.88580388
107Advanced eruption of teeth (HP:0006288)1.87952633
108Full cheeks (HP:0000293)1.87490037
109Autoimmune thrombocytopenia (HP:0001973)1.86475191
110Spinal rigidity (HP:0003306)1.86434252
111Congenital hepatic fibrosis (HP:0002612)1.84712739
112Soft skin (HP:0000977)1.84252825
113Selective tooth agenesis (HP:0001592)1.83643021
114Meningioma (HP:0002858)1.82306229
115Back pain (HP:0003418)1.82140531
116Cystic liver disease (HP:0006706)1.81717709
117Aortic aneurysm (HP:0004942)1.81531905
118Neonatal short-limb short stature (HP:0008921)1.81475167
119Gait imbalance (HP:0002141)1.81188642
120Recurrent abscess formation (HP:0002722)1.80360530
121Patent foramen ovale (HP:0001655)1.80317909
122Abnormalities of placenta or umbilical cord (HP:0001194)1.80153619
123Deviation of the thumb (HP:0009603)1.79189005
124Hypokinesia (HP:0002375)1.78894627
125Palmoplantar hyperkeratosis (HP:0000972)1.78768315
126Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.77799080
127Spinal muscular atrophy (HP:0007269)1.77651829
128Vitreoretinal degeneration (HP:0000655)1.76562490
129Micronodular cirrhosis (HP:0001413)1.76425307
130Fat malabsorption (HP:0002630)1.76403192
131Metaphyseal dysplasia (HP:0100255)1.75901775
132Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75799201
133Palmar hyperkeratosis (HP:0010765)1.75754223
134Poor coordination (HP:0002370)1.75401533
13511 pairs of ribs (HP:0000878)1.74816215
136Neoplasm of the adrenal cortex (HP:0100641)1.74679412
137Long toe (HP:0010511)1.74219270
138Flat capital femoral epiphysis (HP:0003370)1.73675934
139Abnormality of the phalanges of the 5th finger (HP:0004213)1.73498164
140Aortic valve stenosis (HP:0001650)1.72988023
141Submucous cleft hard palate (HP:0000176)1.72809807
142Abnormality of the fovea (HP:0000493)1.72610564
143Vertebral hypoplasia (HP:0008417)1.72430757
144Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72430757
145Thick nail (HP:0001805)1.71501882
146Recurrent pneumonia (HP:0006532)1.71382813
147Bell-shaped thorax (HP:0001591)1.70786891
148Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.70663927
149Abnormality of the nasal septum (HP:0000419)1.70553816
150Abnormality of the metopic suture (HP:0005556)1.70397356
151Irregular epiphyses (HP:0010582)1.69730378
152Reduced subcutaneous adipose tissue (HP:0003758)1.69587183
153Absent frontal sinuses (HP:0002688)1.69386521
154Eczematoid dermatitis (HP:0000976)1.68597231
155Heterochromia iridis (HP:0001100)1.68319073
156Mildly elevated creatine phosphokinase (HP:0008180)1.67908017
157Vertebral arch anomaly (HP:0008438)1.67369044
158Reduced antithrombin III activity (HP:0001976)1.67084533
159Abnormality of carpal bone ossification (HP:0006257)1.66745817
160Bilateral sensorineural hearing impairment (HP:0008619)1.66536142
161Short middle phalanx of the 5th finger (HP:0004220)1.65586083
162Recurrent bacterial skin infections (HP:0005406)1.65399674
163Relative macrocephaly (HP:0004482)1.62477547
164Congenital glaucoma (HP:0001087)1.62438278
165Upper limb amyotrophy (HP:0009129)1.62282901
166Distal upper limb amyotrophy (HP:0007149)1.62282901
167Autoamputation (HP:0001218)1.60634532
168Focal segmental glomerulosclerosis (HP:0000097)1.60457151
169Milia (HP:0001056)1.60301682
170Unilateral renal agenesis (HP:0000122)1.60273546
171Abnormal hair laboratory examination (HP:0003328)1.60026983
172Hypopigmentation of the fundus (HP:0007894)1.59800660
173Breech presentation (HP:0001623)1.57600781
174Hydroxyprolinuria (HP:0003080)1.56628600
175Abnormality of proline metabolism (HP:0010907)1.56628600
176Freckling (HP:0001480)1.56551121
177Hand muscle atrophy (HP:0009130)1.55776322
178Hypobetalipoproteinemia (HP:0003563)1.55219221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.71819100
2MAP3K143.95879895
3PLK43.77361996
4ZAK3.66157812
5SIK33.58750637
6NEK93.44133809
7AKT33.05130581
8FRK2.87980239
9STK38L2.74942172
10SCYL22.72959606
11PAK42.34970513
12MAP3K122.33738453
13PDGFRA2.23516509
14* ERBB32.17476458
15PRPF4B2.17034521
16IRAK42.08610553
17MKNK12.07842005
18PLK22.06047849
19PTK22.05746873
20LATS22.03832170
21MST41.95400734
22SGK21.89293909
23BCR1.85885257
24NEK11.81692307
25YES11.80735914
26IRAK31.76937983
27TSSK61.75517549
28BMPR1B1.73882442
29TRPM71.71831153
30CHUK1.68296617
31STK241.62681515
32PBK1.58867779
33WEE11.52678352
34NUAK11.50892667
35SRPK11.47436151
36PLK31.47357245
37TESK11.42757407
38TRIM281.42308210
39PIM21.40365507
40INSRR1.38982626
41LMTK21.38408887
42STK391.32228739
43TTK1.30184587
44MAP3K21.29757447
45MKNK21.26321210
46EIF2AK21.23065131
47IKBKB1.22411541
48EPHA21.22155321
49SGK4941.17864507
50SGK2231.17864507
51NME21.15178446
52NEK61.13395285
53CASK1.11692008
54TRIB31.10840696
55STK31.05574525
56SGK30.98974626
57IKBKE0.97452439
58NTRK10.96549917
59PAK20.95614973
60EIF2AK10.94320144
61TXK0.94160435
62PDK20.94117687
63FGFR30.93220892
64RIPK10.92104857
65ICK0.91312010
66PIK3CG0.89454536
67KSR10.89404264
68BRSK10.86106506
69MAP3K30.84931806
70EIF2AK30.84864579
71RPS6KA40.83426930
72EPHB10.82211701
73SIK10.81893179
74BRAF0.81329980
75LIMK10.76582510
76ILK0.75833418
77RPS6KB20.73656759
78RPS6KB10.73208616
79STK380.73191649
80EPHA30.72397021
81DDR20.71828067
82MARK30.71403500
83PIM10.71052420
84TEC0.69289002
85PASK0.69167368
86PDGFRB0.69100862
87TTN0.68594577
88MOS0.68147844
89ABL20.67937357
90RPS6KL10.67884946
91RPS6KC10.67884946
92MAPKAPK20.66877095
93RPS6KA60.66449541
94IRAK10.65679897
95LATS10.65565371
96CDK80.64659192
97PKN20.63789625
98PRKCE0.63344501
99ROCK20.63093609
100MYLK0.62984808
101NLK0.62868102
102RPS6KA20.60050859
103ARAF0.59974630
104STK40.59332413
105EEF2K0.59313115
106FGFR10.59082684
107PNCK0.58877600
108KSR20.58386542
109PTK60.57668966
110AKT20.56536105
111CDK70.56035495
112JAK30.55898677
113MELK0.54438082
114MAP3K90.52336848
115PRKCI0.51886582
116BRSK20.51623398
117AURKB0.51267051
118FER0.51089512
119PLK10.48949389
120MAP3K80.46275519
121MAPK150.45452179
122MAPKAPK30.44903786
123STK100.43988189
124VRK10.43543510
125PRKCD0.42453370
126MAPK130.42121327
127MTOR0.40832375
128CDK90.40710423
129TGFBR20.40662485
130ADRBK20.40571237
131FGFR40.40505237
132CDK30.39874658
133MAP2K10.38472783
134BUB10.37671681
135ATR0.36676263
136GRK10.36143800
137PRKG20.36022735
138MET0.34834705
139GSK3A0.34655459
140CDC42BPA0.34442464
141CAMK2D0.34074504
142CSNK2A10.32962250
143CLK10.32632875
144DYRK20.32608036
145ERBB40.31979353
146CAMK2G0.31717205
147TBK10.30523504
148CSNK1A1L0.30482496
149TNK20.29548825
150PINK10.28931558
151NEK20.28703687
152PRKD30.28307514
153BLK0.27796683
154EPHB20.26840130
155TIE10.26583032
156MAPK30.26409338
157TGFBR10.23658403
158CDK60.22739022
159RPS6KA50.20248789

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.72464684
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26479152
3Proteasome_Homo sapiens_hsa030502.08655643
4Legionellosis_Homo sapiens_hsa051342.03052116
5Arachidonic acid metabolism_Homo sapiens_hsa005901.99360642
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91335248
7Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87235155
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.87072270
9Vitamin B6 metabolism_Homo sapiens_hsa007501.82352054
10SNARE interactions in vesicular transport_Homo sapiens_hsa041301.76875144
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.72202696
12Sulfur metabolism_Homo sapiens_hsa009201.71058972
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70186350
14Graft-versus-host disease_Homo sapiens_hsa053321.58759511
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56954332
16Non-homologous end-joining_Homo sapiens_hsa034501.55540932
17Rheumatoid arthritis_Homo sapiens_hsa053231.54811669
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.54624013
19Proteoglycans in cancer_Homo sapiens_hsa052051.52716939
20Phagosome_Homo sapiens_hsa041451.49796878
21Small cell lung cancer_Homo sapiens_hsa052221.46411009
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46106707
23One carbon pool by folate_Homo sapiens_hsa006701.45795915
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43148726
25Focal adhesion_Homo sapiens_hsa045101.41814464
26N-Glycan biosynthesis_Homo sapiens_hsa005101.36498389
27Pentose phosphate pathway_Homo sapiens_hsa000301.35748337
28Bladder cancer_Homo sapiens_hsa052191.35258204
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34013073
30Allograft rejection_Homo sapiens_hsa053301.30967899
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.30525649
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30289595
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27570043
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.25452079
35Other glycan degradation_Homo sapiens_hsa005111.24640996
36Base excision repair_Homo sapiens_hsa034101.20905204
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18928221
38RNA polymerase_Homo sapiens_hsa030201.17966256
39Fructose and mannose metabolism_Homo sapiens_hsa000511.17769279
40Leishmaniasis_Homo sapiens_hsa051401.17377018
41Tight junction_Homo sapiens_hsa045301.16252499
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15761817
43Biosynthesis of amino acids_Homo sapiens_hsa012301.15428941
44Fatty acid elongation_Homo sapiens_hsa000621.14499435
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13583236
46Galactose metabolism_Homo sapiens_hsa000521.12240390
47Arginine biosynthesis_Homo sapiens_hsa002201.10885374
48Adherens junction_Homo sapiens_hsa045201.09055451
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08818615
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08479456
51TNF signaling pathway_Homo sapiens_hsa046681.07705969
52Pertussis_Homo sapiens_hsa051331.07536586
53Vibrio cholerae infection_Homo sapiens_hsa051101.06685182
54Malaria_Homo sapiens_hsa051441.06674930
55Carbon metabolism_Homo sapiens_hsa012001.06372634
56Basal transcription factors_Homo sapiens_hsa030221.06270582
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05862208
58Apoptosis_Homo sapiens_hsa042101.04092532
59Influenza A_Homo sapiens_hsa051641.03379660
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03304557
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.03176288
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02320284
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02261226
64Steroid biosynthesis_Homo sapiens_hsa001001.02163259
65Type I diabetes mellitus_Homo sapiens_hsa049401.00986527
66Homologous recombination_Homo sapiens_hsa034401.00979832
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.98169765
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96099540
69Staphylococcus aureus infection_Homo sapiens_hsa051500.95959448
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95054235
71Glutathione metabolism_Homo sapiens_hsa004800.94833832
72Prostate cancer_Homo sapiens_hsa052150.94614384
73Lysosome_Homo sapiens_hsa041420.94273701
74TGF-beta signaling pathway_Homo sapiens_hsa043500.92189104
75Pancreatic cancer_Homo sapiens_hsa052120.92173624
76Autoimmune thyroid disease_Homo sapiens_hsa053200.91815306
77Pyruvate metabolism_Homo sapiens_hsa006200.91104046
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91028026
79Herpes simplex infection_Homo sapiens_hsa051680.91006622
80MicroRNAs in cancer_Homo sapiens_hsa052060.90170495
81Pyrimidine metabolism_Homo sapiens_hsa002400.90146361
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89793447
83Thyroid cancer_Homo sapiens_hsa052160.89585183
84Starch and sucrose metabolism_Homo sapiens_hsa005000.89325045
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89311856
86Protein digestion and absorption_Homo sapiens_hsa049740.88726479
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.88070405
88p53 signaling pathway_Homo sapiens_hsa041150.87945299
89Measles_Homo sapiens_hsa051620.87559107
90Renal cell carcinoma_Homo sapiens_hsa052110.87340380
91Hepatitis C_Homo sapiens_hsa051600.87241014
92Prolactin signaling pathway_Homo sapiens_hsa049170.85904238
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85324331
94Renin-angiotensin system_Homo sapiens_hsa046140.84379850
95Chronic myeloid leukemia_Homo sapiens_hsa052200.84230104
96Sphingolipid metabolism_Homo sapiens_hsa006000.83987665
97Cell cycle_Homo sapiens_hsa041100.82777991
98Purine metabolism_Homo sapiens_hsa002300.80626246
99Fanconi anemia pathway_Homo sapiens_hsa034600.80521866
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80464530
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.80223026
102RNA degradation_Homo sapiens_hsa030180.79750956
103Melanoma_Homo sapiens_hsa052180.79594234
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79019956
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78820463
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.78312737
107Tuberculosis_Homo sapiens_hsa051520.77005494
108Chemical carcinogenesis_Homo sapiens_hsa052040.76415272
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75846235
110Circadian rhythm_Homo sapiens_hsa047100.75313196
111Arginine and proline metabolism_Homo sapiens_hsa003300.74353336
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73722755
113Notch signaling pathway_Homo sapiens_hsa043300.73214400
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73011673
115Endometrial cancer_Homo sapiens_hsa052130.72907175
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72663423
117Epstein-Barr virus infection_Homo sapiens_hsa051690.72035692
118Amoebiasis_Homo sapiens_hsa051460.70121062
119Inositol phosphate metabolism_Homo sapiens_hsa005620.70037335
120Mismatch repair_Homo sapiens_hsa034300.69674380
121Phenylalanine metabolism_Homo sapiens_hsa003600.69623830
122Asthma_Homo sapiens_hsa053100.69520169
123FoxO signaling pathway_Homo sapiens_hsa040680.68973559
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68673062
125Shigellosis_Homo sapiens_hsa051310.68417970
126Toxoplasmosis_Homo sapiens_hsa051450.68268417
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67963064
128Hippo signaling pathway_Homo sapiens_hsa043900.66321866
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66233956
130Mineral absorption_Homo sapiens_hsa049780.66229187
131Prion diseases_Homo sapiens_hsa050200.64091747
132Peroxisome_Homo sapiens_hsa041460.63236294
133Tyrosine metabolism_Homo sapiens_hsa003500.62813493
134ECM-receptor interaction_Homo sapiens_hsa045120.62189578
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62117418
136RNA transport_Homo sapiens_hsa030130.61750515
137Nucleotide excision repair_Homo sapiens_hsa034200.61440321
138DNA replication_Homo sapiens_hsa030300.61360185
139Folate biosynthesis_Homo sapiens_hsa007900.59466446
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.59449411
141Pathways in cancer_Homo sapiens_hsa052000.59274158
142Hematopoietic cell lineage_Homo sapiens_hsa046400.58148099
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58098398
144Salmonella infection_Homo sapiens_hsa051320.57087030
145Histidine metabolism_Homo sapiens_hsa003400.56569097
146Fatty acid metabolism_Homo sapiens_hsa012120.55885833
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.55282448
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55147224
149Hepatitis B_Homo sapiens_hsa051610.54648044
150Glioma_Homo sapiens_hsa052140.54034256
151Antigen processing and presentation_Homo sapiens_hsa046120.53871030
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53774719
153Caffeine metabolism_Homo sapiens_hsa002320.53399888
154PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53384028
155Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53306221
156Colorectal cancer_Homo sapiens_hsa052100.49725927
157Endocytosis_Homo sapiens_hsa041440.49687307
158Fatty acid biosynthesis_Homo sapiens_hsa000610.49306007
159Propanoate metabolism_Homo sapiens_hsa006400.48038281
160Thyroid hormone synthesis_Homo sapiens_hsa049180.47761579
161AMPK signaling pathway_Homo sapiens_hsa041520.43267247

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