TWF1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.73640245
2cytidine metabolic process (GO:0046087)6.90111508
3cytidine catabolic process (GO:0006216)6.90111508
4cytidine deamination (GO:0009972)6.90111508
5diterpenoid biosynthetic process (GO:0016102)6.04672581
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.52540660
7DNA deamination (GO:0045006)4.77078189
8terpenoid biosynthetic process (GO:0016114)4.67795527
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.67268469
10eosinophil chemotaxis (GO:0048245)4.39748661
11membrane raft organization (GO:0031579)4.13710444
12negative regulation of protein localization to cell surface (GO:2000009)3.99651477
13ER overload response (GO:0006983)3.99340461
14CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.91839558
15eosinophil migration (GO:0072677)3.86497103
16inositol phosphate-mediated signaling (GO:0048016)3.74384189
17regulation of transmission of nerve impulse (GO:0051969)3.62831588
18response to peptidoglycan (GO:0032494)3.52145783
19retinal metabolic process (GO:0042574)3.49792861
20interleukin-6-mediated signaling pathway (GO:0070102)3.44815369
21hemidesmosome assembly (GO:0031581)3.40329616
22xenobiotic catabolic process (GO:0042178)3.39300715
23mitotic cytokinesis (GO:0000281)3.37544024
24branch elongation of an epithelium (GO:0060602)3.36002780
25protein targeting to vacuole (GO:0006623)3.31898911
26protein targeting to lysosome (GO:0006622)3.31898911
27establishment of protein localization to vacuole (GO:0072666)3.31898911
28energy homeostasis (GO:0097009)3.30384273
29monocyte chemotaxis (GO:0002548)3.30241685
30positive regulation of type 2 immune response (GO:0002830)3.27974044
31positive regulation of bone remodeling (GO:0046852)3.23682118
32positive regulation of bone resorption (GO:0045780)3.23682118
33negative regulation of macroautophagy (GO:0016242)3.21264490
34ganglioside metabolic process (GO:0001573)3.19730414
35regulation of chemokine-mediated signaling pathway (GO:0070099)3.17432997
36artery smooth muscle contraction (GO:0014824)3.13440621
37cytoskeleton-dependent cytokinesis (GO:0061640)3.09838165
38response to lipoprotein particle (GO:0055094)3.08904713
39positive regulation of p38MAPK cascade (GO:1900745)3.08792902
40regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.07366066
41positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.07366066
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06201000
43protein localization to lysosome (GO:0061462)3.06069506
44protein localization to vacuole (GO:0072665)3.06069506
45decidualization (GO:0046697)3.02646556
46actin nucleation (GO:0045010)3.02280832
47centriole replication (GO:0007099)2.99987712
48Golgi to plasma membrane protein transport (GO:0043001)2.98279783
49T cell lineage commitment (GO:0002360)2.96287875
50regulation of axon regeneration (GO:0048679)2.94197347
51regulation of neuron projection regeneration (GO:0070570)2.94197347
52positive regulation of heat generation (GO:0031652)2.93968608
53response to caffeine (GO:0031000)2.93172327
54cellular response to ATP (GO:0071318)2.91519966
55regulation of collateral sprouting (GO:0048670)2.90504979
56regulation of MHC class I biosynthetic process (GO:0045343)2.87024305
57positive regulation of tissue remodeling (GO:0034105)2.83106121
58cullin deneddylation (GO:0010388)2.82156893
59intestinal epithelial cell development (GO:0060576)2.79117672
60pyrimidine nucleoside catabolic process (GO:0046135)2.77115649
61positive regulation of T-helper cell differentiation (GO:0045624)2.76958230
62response to xenobiotic stimulus (GO:0009410)2.75935660
63negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.75484202
64regulation of mononuclear cell migration (GO:0071675)2.75130424
65metaphase plate congression (GO:0051310)2.74228267
66tonic smooth muscle contraction (GO:0014820)2.72240069
67positive regulation of prostaglandin secretion (GO:0032308)2.72203301
68negative regulation of viral genome replication (GO:0045071)2.71674377
69negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.71597361
70indolalkylamine metabolic process (GO:0006586)2.71284001
71regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.71258730
72production of molecular mediator of immune response (GO:0002440)2.71232497
73proteasome assembly (GO:0043248)2.70811054
74mesenchymal-epithelial cell signaling (GO:0060638)2.68226469
75negative regulation of complement activation (GO:0045916)2.65966808
76neutrophil mediated immunity (GO:0002446)2.65839141
77natural killer cell activation involved in immune response (GO:0002323)2.65557348
78positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.65100621
79regulation of T-helper 1 cell differentiation (GO:0045625)2.63406329
80regulation of defense response to virus by host (GO:0050691)2.62753015
81response to vitamin D (GO:0033280)2.62284090
82regulation of fever generation (GO:0031620)2.61473742
83regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.60946553
84negative regulation of gluconeogenesis (GO:0045721)2.60872245
85response to pheromone (GO:0019236)2.60677865
86fibroblast migration (GO:0010761)2.60500900
87kynurenine metabolic process (GO:0070189)2.59971100
88protein targeting to Golgi (GO:0000042)2.58399389
89negative regulation of acute inflammatory response (GO:0002674)2.58002171
90positive regulation of acute inflammatory response (GO:0002675)2.57872080
91positive regulation of defense response to virus by host (GO:0002230)2.57853239
92negative regulation of nitric oxide biosynthetic process (GO:0045019)2.57067570
93spindle assembly involved in mitosis (GO:0090307)2.57037981
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.55678813
95regulation of T-helper 2 cell differentiation (GO:0045628)2.53684770
96establishment of protein localization to Golgi (GO:0072600)2.51974849
97positive regulation of calcium ion import (GO:0090280)2.51671355
98regulation of interferon-alpha production (GO:0032647)2.49924860
99negative regulation of cytokine biosynthetic process (GO:0042036)2.49423942
100establishment of chromosome localization (GO:0051303)2.48515206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.61508019
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.17093743
3IGF1R_20145208_ChIP-Seq_DFB_Human2.90593914
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.90565389
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.87019963
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76512855
7TP53_16413492_ChIP-PET_HCT116_Human2.73925532
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.65259678
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51181642
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36386169
11ELK1_19687146_ChIP-ChIP_HELA_Human2.27773768
12VDR_22108803_ChIP-Seq_LS180_Human2.09572179
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08938107
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.03335461
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00860559
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.99968497
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87551823
18TP53_18474530_ChIP-ChIP_U2OS_Human1.86816631
19CJUN_26792858_Chip-Seq_BT549_Human1.82523434
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78490115
21AHR_22903824_ChIP-Seq_MCF-7_Human1.77560680
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77358449
23GBX2_23144817_ChIP-Seq_PC3_Human1.74997716
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67547305
25P300_19829295_ChIP-Seq_ESCs_Human1.64329102
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.63820640
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.62552498
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62238847
29BCAT_22108803_ChIP-Seq_LS180_Human1.61919357
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60867003
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60853754
32TAF15_26573619_Chip-Seq_HEK293_Human1.60682889
33BRD4_25478319_ChIP-Seq_HGPS_Human1.59483981
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56429006
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56429006
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56256482
37JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54488028
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53910468
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.52540833
40EWS_26573619_Chip-Seq_HEK293_Human1.50452208
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50413938
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49989140
43JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48873656
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48622355
45SMAD4_21799915_ChIP-Seq_A2780_Human1.47881225
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45605468
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44110886
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42324398
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42324398
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.41393686
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.40370207
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.37171687
53CDX2_22108803_ChIP-Seq_LS180_Human1.33015237
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31602380
55TP63_23658742_ChIP-Seq_EP156T_Human1.30759549
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.30389569
57CBP_20019798_ChIP-Seq_JUKART_Human1.30357636
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30357636
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27733440
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26994471
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26984056
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26231041
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.26093368
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25421434
65FUS_26573619_Chip-Seq_HEK293_Human1.25069093
66AR_25329375_ChIP-Seq_VCAP_Human1.21665823
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21508241
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.20652277
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19004647
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18791325
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18451875
72STAT3_23295773_ChIP-Seq_U87_Human1.18117456
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17170751
74ER_23166858_ChIP-Seq_MCF-7_Human1.16738494
75NFYB_21822215_ChIP-Seq_K562_Human1.16027410
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.13992932
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13201633
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10435812
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08063752
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07730729
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07158756
82TBL1_22424771_ChIP-Seq_293T_Human1.07086617
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06815436
84AR_20517297_ChIP-Seq_VCAP_Human1.06146709
85PHF8_20622853_ChIP-Seq_HELA_Human1.04584659
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03054893
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.02790389
88SOX2_20726797_ChIP-Seq_SW620_Human1.01559855
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00012749
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.99693333
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98064281
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97606284
93HNFA_21074721_ChIP-Seq_CACO-2_Human0.97428264
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97388381
95SOX2_19829295_ChIP-Seq_ESCs_Human0.97356154
96NANOG_19829295_ChIP-Seq_ESCs_Human0.97356154
97GATA3_26560356_Chip-Seq_TH2_Human0.96151894
98TCF4_22108803_ChIP-Seq_LS180_Human0.95733823
99GATA4_25053715_ChIP-Seq_YYC3_Human0.94883640
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94810161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis8.53798742
2MP0006082_CNS_inflammation6.79950546
3MP0003950_abnormal_plasma_membrane4.02331444
4MP0000569_abnormal_digit_pigmentation3.36669162
5MP0003806_abnormal_nucleotide_metabolis3.29915759
6MP0004272_abnormal_basement_membrane2.99353642
7MP0009840_abnormal_foam_cell2.71156990
8MP0002332_abnormal_exercise_endurance2.60345781
9MP0009785_altered_susceptibility_to2.43096949
10MP0005408_hypopigmentation2.09155156
11MP0002148_abnormal_hypersensitivity_rea2.03533260
12MP0002163_abnormal_gland_morphology2.00615163
13MP0002139_abnormal_hepatobiliary_system1.99414544
14MP0005360_urolithiasis1.97236267
15MP0000920_abnormal_myelination1.80626943
16MP0002102_abnormal_ear_morphology1.77351510
17MP0003283_abnormal_digestive_organ1.77310301
18MP0009278_abnormal_bone_marrow1.74363746
19MP0002837_dystrophic_cardiac_calcinosis1.73637507
20MP0005084_abnormal_gallbladder_morpholo1.72590333
21MP0005379_endocrine/exocrine_gland_phen1.66061886
22MP0002254_reproductive_system_inflammat1.55209897
23MP0003252_abnormal_bile_duct1.53045762
24MP0010678_abnormal_skin_adnexa1.49640941
25MP0005164_abnormal_response_to1.49305199
26MP0002138_abnormal_hepatobiliary_system1.46780673
27MP0005023_abnormal_wound_healing1.45668283
28MP0005310_abnormal_salivary_gland1.42941441
29MP0000749_muscle_degeneration1.37310970
30MP0005387_immune_system_phenotype1.31966720
31MP0001790_abnormal_immune_system1.31966720
32MP0010386_abnormal_urinary_bladder1.30620076
33MP0000383_abnormal_hair_follicle1.26732706
34MP0003690_abnormal_glial_cell1.26176539
35MP0005000_abnormal_immune_tolerance1.24170590
36MP0005266_abnormal_metabolism1.23777800
37MP0005397_hematopoietic_system_phenotyp1.20126612
38MP0001545_abnormal_hematopoietic_system1.20126612
39MP0003091_abnormal_cell_migration1.20093934
40MP0005165_increased_susceptibility_to1.13231943
41MP0002877_abnormal_melanocyte_morpholog1.10227308
42MP0001501_abnormal_sleep_pattern1.09883763
43MP0005671_abnormal_response_to1.06826668
44MP0004883_abnormal_blood_vessel1.02728999
45MP0002277_abnormal_respiratory_mucosa1.02687826
46MP0010234_abnormal_vibrissa_follicle1.00402119
47MP0002168_other_aberrant_phenotype1.00337767
48MP0002269_muscular_atrophy0.97307337
49MP0000343_altered_response_to0.96566250
50MP0001873_stomach_inflammation0.96529777
51MP0000371_diluted_coat_color0.96292769
52MP0003045_fibrosis0.96082697
53MP0005332_abnormal_amino_acid0.95071441
54MP0008875_abnormal_xenobiotic_pharmacok0.94536604
55MP0003136_yellow_coat_color0.94114160
56MP0002006_tumorigenesis0.93956114
57MP0004947_skin_inflammation0.93537845
58MP0006054_spinal_hemorrhage0.92856430
59MP0001191_abnormal_skin_condition0.91813010
60MP0009053_abnormal_anal_canal0.89434495
61MP0005167_abnormal_blood-brain_barrier0.86314834
62MP0001835_abnormal_antigen_presentation0.85217050
63MP0005376_homeostasis/metabolism_phenot0.85172041
64MP0002734_abnormal_mechanical_nocicepti0.81231869
65MP0002095_abnormal_skin_pigmentation0.80866092
66MP0001845_abnormal_inflammatory_respons0.80565725
67MP0001800_abnormal_humoral_immune0.78375650
68MP0003724_increased_susceptibility_to0.78313197
69MP0009333_abnormal_splenocyte_physiolog0.78292507
70MP0002876_abnormal_thyroid_physiology0.76301027
71MP0002452_abnormal_antigen_presenting0.76178281
72MP0002166_altered_tumor_susceptibility0.75923971
73MP0002693_abnormal_pancreas_physiology0.75853506
74MP0002723_abnormal_immune_serum0.75811040
75MP0001243_abnormal_dermal_layer0.73932264
76MP0005595_abnormal_vascular_smooth0.73413144
77MP0002638_abnormal_pupillary_reflex0.73234116
78MP0000685_abnormal_immune_system0.72215005
79MP0002419_abnormal_innate_immunity0.69616507
80MP0002796_impaired_skin_barrier0.69062871
81MP0001346_abnormal_lacrimal_gland0.67291325
82MP0001529_abnormal_vocalization0.66238956
83MP0005166_decreased_susceptibility_to0.65875399
84MP0002136_abnormal_kidney_physiology0.65222845
85MP0002234_abnormal_pharynx_morphology0.65208556
86MP0005645_abnormal_hypothalamus_physiol0.64647449
87MP0002295_abnormal_pulmonary_circulatio0.63457241
88MP0001764_abnormal_homeostasis0.63251092
89MP0005647_abnormal_sex_gland0.62068562
90MP0005025_abnormal_response_to0.58358827
91MP0001905_abnormal_dopamine_level0.57999604
92MP0008469_abnormal_protein_level0.57782009
93MP0009764_decreased_sensitivity_to0.57064719
94MP0009643_abnormal_urine_homeostasis0.56974045
95MP0006035_abnormal_mitochondrial_morpho0.56914508
96MP0003453_abnormal_keratinocyte_physiol0.56874470
97MP0003303_peritoneal_inflammation0.56732217
98MP0000372_irregular_coat_pigmentation0.56186829
99MP0003633_abnormal_nervous_system0.55391849
100MP0009763_increased_sensitivity_to0.54988326

Predicted human phenotypes

RankGene SetZ-score
1Hyperkalemia (HP:0002153)5.57432672
2Urethral obstruction (HP:0000796)5.47976515
3Stenosis of the external auditory canal (HP:0000402)5.44626479
4Thick nail (HP:0001805)4.17243551
5Autoimmune hemolytic anemia (HP:0001890)3.92488781
6Increased IgM level (HP:0003496)3.79421584
7Autoimmune thrombocytopenia (HP:0001973)3.57747577
8Milia (HP:0001056)3.51110083
9Alopecia of scalp (HP:0002293)3.39169815
10Posterior subcapsular cataract (HP:0007787)3.36361046
11Supranuclear gaze palsy (HP:0000605)3.30875868
12Pancreatic cysts (HP:0001737)3.29919007
13Abnormality of liposaccharide metabolism (HP:0010968)3.26723065
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.26723065
15Abnormality of glycolipid metabolism (HP:0010969)3.26723065
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.23555519
17Mitral stenosis (HP:0001718)3.21940079
18Vascular calcification (HP:0004934)3.20819007
19Lip pit (HP:0100267)3.12437224
20Abnormality of midbrain morphology (HP:0002418)3.05185117
21Molar tooth sign on MRI (HP:0002419)3.05185117
22Type I transferrin isoform profile (HP:0003642)3.05126564
23Prolonged neonatal jaundice (HP:0006579)3.04233567
24Hyponatremia (HP:0002902)3.03667220
25Atonic seizures (HP:0010819)3.02452567
26Abnormality of T cell number (HP:0011839)2.92034842
27Cardiovascular calcification (HP:0011915)2.81659383
28Termporal pattern (HP:0011008)2.74038290
29Insidious onset (HP:0003587)2.74038290
30Prostate neoplasm (HP:0100787)2.73875021
31Exercise-induced muscle cramps (HP:0003710)2.62168677
32Abnormal protein glycosylation (HP:0012346)2.50858527
33Abnormal glycosylation (HP:0012345)2.50858527
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50858527
35Abnormal protein N-linked glycosylation (HP:0012347)2.50858527
36Glossoptosis (HP:0000162)2.48556465
37Azoospermia (HP:0000027)2.47682443
38Abnormality of macrophages (HP:0004311)2.44112490
39Abnormality of renal excretion (HP:0011036)2.44044068
40Vacuolated lymphocytes (HP:0001922)2.42131297
41Neurofibrillary tangles (HP:0002185)2.41932445
42Exocrine pancreatic insufficiency (HP:0001738)2.39830061
43Potter facies (HP:0002009)2.37398349
44Facial shape deformation (HP:0011334)2.37398349
45Hyperventilation (HP:0002883)2.35778211
46Bifid tongue (HP:0010297)2.32316473
47Tubular atrophy (HP:0000092)2.30879246
48Loss of speech (HP:0002371)2.27061514
49Intrahepatic cholestasis (HP:0001406)2.24433110
50Scanning speech (HP:0002168)2.23846984
51Abnormality of T cell physiology (HP:0011840)2.23781168
52Aplastic anemia (HP:0001915)2.23565612
53Volvulus (HP:0002580)2.23471029
54Abnormal auditory evoked potentials (HP:0006958)2.23088295
55Pheochromocytoma (HP:0002666)2.18209151
56Hypokinesia (HP:0002375)2.13876931
57Median cleft lip (HP:0000161)2.10523567
58Abnormality of sodium homeostasis (HP:0010931)2.10089930
59Parakeratosis (HP:0001036)2.06969166
60Reduced antithrombin III activity (HP:0001976)2.04565519
61Abnormality of potassium homeostasis (HP:0011042)2.02729315
62Late onset (HP:0003584)2.00759303
63Polydipsia (HP:0001959)1.99361320
64Abnormal drinking behavior (HP:0030082)1.99361320
65Horizontal nystagmus (HP:0000666)1.99219776
66Abnormal urine output (HP:0012590)1.99190753
67Febrile seizures (HP:0002373)1.98589325
68Tetraparesis (HP:0002273)1.97238347
69Hypothermia (HP:0002045)1.96547623
70Microretrognathia (HP:0000308)1.96147603
71Absent speech (HP:0001344)1.95994038
72Neuroendocrine neoplasm (HP:0100634)1.95716254
73Glycosuria (HP:0003076)1.95382021
74Abnormality of urine glucose concentration (HP:0011016)1.95382021
75Neonatal respiratory distress (HP:0002643)1.93142219
76Joint swelling (HP:0001386)1.92520181
77Choroideremia (HP:0001139)1.92229984
78J-shaped sella turcica (HP:0002680)1.90465587
79Increased CSF protein (HP:0002922)1.89208434
80Hypoplasia of dental enamel (HP:0006297)1.89026852
81Eosinophilia (HP:0001880)1.86367362
82Tubulointerstitial fibrosis (HP:0005576)1.84190040
83Fatigable weakness (HP:0003473)1.83499545
84Abnormality of the neuromuscular junction (HP:0003398)1.83499545
85Short chin (HP:0000331)1.82438184
86Pancreatic fibrosis (HP:0100732)1.81864921
87Zonular cataract (HP:0010920)1.81297934
88Bradycardia (HP:0001662)1.80401939
89Generalized hypopigmentation of hair (HP:0011358)1.80249159
90Cystic liver disease (HP:0006706)1.77923700
91Subcapsular cataract (HP:0000523)1.76541644
92Petechiae (HP:0000967)1.74312916
93Hyperglycemia (HP:0003074)1.73686820
94Hydroxyprolinuria (HP:0003080)1.71890302
95Abnormality of proline metabolism (HP:0010907)1.71890302
96T lymphocytopenia (HP:0005403)1.71684215
97Microvesicular hepatic steatosis (HP:0001414)1.70270570
98Abnormality of renal resorption (HP:0011038)1.69852047
99Progressive neurologic deterioration (HP:0002344)1.68283307
100Steatorrhea (HP:0002570)1.68128405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.92048797
2MAP3K124.67684058
3MST43.53504802
4MST1R3.17561636
5BCR3.04167256
6TNIK3.03736970
7BMPR22.80523692
8EIF2AK32.58163907
9ZAK2.54554994
10PDK22.43951956
11IRAK32.43057815
12CDK82.24982693
13SCYL22.23402495
14PLK22.14742353
15MYLK2.14465040
16PIK3CG1.99722316
17BRD41.97375182
18BMPR1B1.90488357
19TLK11.86367411
20MAP4K21.86276380
21ERBB31.72240117
22FRK1.52350877
23ACVR1B1.38893830
24DAPK31.35699081
25STK38L1.33112988
26MAP3K41.28818274
27VRK11.23141350
28MET1.14542428
29EIF2AK11.14331401
30ABL21.11792099
31VRK21.11490411
32IRAK21.10525815
33ADRBK21.08828360
34ERBB41.03004916
35EPHA20.99882202
36DAPK10.99402254
37TRPM70.99305151
38PAK40.94038416
39KDR0.91096925
40PBK0.87065567
41NEK90.84764245
42GRK10.83938940
43NEK10.83799412
44CLK10.82405648
45PDGFRB0.80190559
46TAF10.77652013
47MAP3K20.74134304
48ROCK10.73706508
49BRSK20.71890300
50MAP3K140.69574126
51GRK70.69497056
52PLK30.68612015
53IRAK40.68226639
54LATS20.66793349
55FER0.66692465
56IKBKB0.66097372
57NEK20.62593957
58MAP3K30.62590746
59WEE10.62456806
60LATS10.61765858
61PKN10.59423173
62STK100.58722077
63TBK10.57799636
64MELK0.57152965
65PRKCE0.51206332
66STK390.50386832
67MAPKAPK50.49912057
68STK30.49269676
69NUAK10.48577051
70ADRBK10.48460574
71BUB10.48344224
72CDK90.47733836
73LIMK10.47279071
74DAPK20.45752182
75PNCK0.41366116
76AURKA0.41131852
77TRIM280.40777375
78PRKG10.38355603
79TAOK20.38087549
80CSNK1G20.37360723
81PLK10.37095809
82KSR10.36973214
83MKNK10.36421320
84WNK30.34820369
85MAP2K70.33805187
86ILK0.33071731
87MKNK20.32245005
88MAP3K60.31919628
89RPS6KA50.30249786
90PRKCQ0.28639589
91RIPK10.28435320
92MAP3K50.27247915
93CAMKK20.26984300
94PRKCI0.26652054
95TESK20.24739641
96TESK10.24520625
97PAK30.23962174
98GSK3A0.23345941
99EIF2AK20.23066503
100CAMK2D0.22381504

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.55060401
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.89540328
3Renin-angiotensin system_Homo sapiens_hsa046142.75680711
4Proteasome_Homo sapiens_hsa030502.57906139
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.37590430
6African trypanosomiasis_Homo sapiens_hsa051432.34326415
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.28773952
8Graft-versus-host disease_Homo sapiens_hsa053322.26589512
9Rheumatoid arthritis_Homo sapiens_hsa053232.18199422
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17874416
11Legionellosis_Homo sapiens_hsa051342.01401866
12Type I diabetes mellitus_Homo sapiens_hsa049401.97357713
13Protein export_Homo sapiens_hsa030601.89976139
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82735546
15Malaria_Homo sapiens_hsa051441.82476481
16Allograft rejection_Homo sapiens_hsa053301.76558380
17Pertussis_Homo sapiens_hsa051331.57629426
18Sphingolipid metabolism_Homo sapiens_hsa006001.46554566
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45146649
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.44859138
21Autoimmune thyroid disease_Homo sapiens_hsa053201.41355392
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39961810
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37361182
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.35640771
25Measles_Homo sapiens_hsa051621.35314704
26Shigellosis_Homo sapiens_hsa051311.32680059
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27707567
28Oxidative phosphorylation_Homo sapiens_hsa001901.27012670
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.26219294
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24190650
31N-Glycan biosynthesis_Homo sapiens_hsa005101.24118834
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23266414
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21152918
34Tryptophan metabolism_Homo sapiens_hsa003801.20188266
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16038928
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15870708
37Mineral absorption_Homo sapiens_hsa049781.15557538
38Hematopoietic cell lineage_Homo sapiens_hsa046401.15219294
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11331265
40Glutathione metabolism_Homo sapiens_hsa004801.08275262
41p53 signaling pathway_Homo sapiens_hsa041151.06715583
42Salmonella infection_Homo sapiens_hsa051321.05641037
43Sulfur metabolism_Homo sapiens_hsa009201.05434562
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05178760
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05172504
46Asthma_Homo sapiens_hsa053101.04226311
47TNF signaling pathway_Homo sapiens_hsa046681.02450897
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00901991
49Lysosome_Homo sapiens_hsa041420.98713674
50Parkinsons disease_Homo sapiens_hsa050120.96891223
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96838753
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92062919
53Antigen processing and presentation_Homo sapiens_hsa046120.89473929
54Collecting duct acid secretion_Homo sapiens_hsa049660.89266377
55Regulation of autophagy_Homo sapiens_hsa041400.88587502
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86881553
57Starch and sucrose metabolism_Homo sapiens_hsa005000.85525150
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85162559
59Chemical carcinogenesis_Homo sapiens_hsa052040.82613660
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82398737
61Viral myocarditis_Homo sapiens_hsa054160.81981453
62Butanoate metabolism_Homo sapiens_hsa006500.81605169
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78052100
64Alzheimers disease_Homo sapiens_hsa050100.75398362
65Vibrio cholerae infection_Homo sapiens_hsa051100.75076679
66Influenza A_Homo sapiens_hsa051640.69465540
67Circadian rhythm_Homo sapiens_hsa047100.63870357
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62898204
69Herpes simplex infection_Homo sapiens_hsa051680.61011926
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.59406126
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.59327373
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.58853244
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58331828
74Primary immunodeficiency_Homo sapiens_hsa053400.55439932
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54895430
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53812316
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53175194
78Fatty acid elongation_Homo sapiens_hsa000620.51651326
79Retinol metabolism_Homo sapiens_hsa008300.51393033
80Basal transcription factors_Homo sapiens_hsa030220.48324884
81Tuberculosis_Homo sapiens_hsa051520.46777571
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.46497305
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43415549
84Systemic lupus erythematosus_Homo sapiens_hsa053220.43120513
85FoxO signaling pathway_Homo sapiens_hsa040680.42857116
86Huntingtons disease_Homo sapiens_hsa050160.42794375
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42296913
88Toxoplasmosis_Homo sapiens_hsa051450.40606354
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32590011
90Tight junction_Homo sapiens_hsa045300.32274215
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31799856
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30597217
93Hepatitis C_Homo sapiens_hsa051600.30469945
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30110111
95Adherens junction_Homo sapiens_hsa045200.29915373
96Complement and coagulation cascades_Homo sapiens_hsa046100.29768844
97ECM-receptor interaction_Homo sapiens_hsa045120.27018521
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24703957
99Vitamin B6 metabolism_Homo sapiens_hsa007500.24676016
100Dorso-ventral axis formation_Homo sapiens_hsa043200.23711692

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