TWF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34093818
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34093818
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.28616976
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.28616976
5modulation by symbiont of host immune response (GO:0052553)4.28616976
6positive regulation by symbiont of host defense response (GO:0052509)4.28616976
7modulation by symbiont of host defense response (GO:0052031)4.28616976
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.28616976
9positive regulation of gamma-delta T cell activation (GO:0046645)4.25976275
10antigen processing and presentation of endogenous antigen (GO:0019883)3.95983957
11Arp2/3 complex-mediated actin nucleation (GO:0034314)3.94760856
12negative regulation of erythrocyte differentiation (GO:0045647)3.80527572
13ribosomal small subunit assembly (GO:0000028)3.76896119
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.76763026
15detection of other organism (GO:0098543)3.76135894
16detection of bacterium (GO:0016045)3.69331557
17cellular response to zinc ion (GO:0071294)3.66120821
18sarcomere organization (GO:0045214)3.65869318
19DNA deamination (GO:0045006)3.65572490
20regulation of mast cell degranulation (GO:0043304)3.64764383
21negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.63820700
22regulation of B cell receptor signaling pathway (GO:0050855)3.63577813
23muscle filament sliding (GO:0030049)3.63328086
24actin-myosin filament sliding (GO:0033275)3.63328086
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60964141
26macrophage activation involved in immune response (GO:0002281)3.57037064
27regulation of gamma-delta T cell differentiation (GO:0045586)3.45893053
28leukocyte aggregation (GO:0070486)3.41520536
29regulation of leukocyte degranulation (GO:0043300)3.36517001
30IMP metabolic process (GO:0046040)3.36437984
31DNA strand elongation involved in DNA replication (GO:0006271)3.34242685
32regulation of myeloid leukocyte mediated immunity (GO:0002886)3.31515635
33regulation of mast cell activation involved in immune response (GO:0033006)3.21557807
34telomere maintenance via semi-conservative replication (GO:0032201)3.19946792
35viral transcription (GO:0019083)3.17751297
36regulation of gamma-delta T cell activation (GO:0046643)3.16655302
37immunoglobulin mediated immune response (GO:0016064)3.15180051
38positive thymic T cell selection (GO:0045059)3.15008581
39detection of external biotic stimulus (GO:0098581)3.14849094
40IMP biosynthetic process (GO:0006188)3.14256571
41DNA strand elongation (GO:0022616)3.12664912
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11143404
43protein localization to endosome (GO:0036010)3.09961464
44granulocyte activation (GO:0036230)3.09183785
45regulation of interferon-beta biosynthetic process (GO:0045357)3.08976153
46neutrophil activation (GO:0042119)3.07801272
47DNA unwinding involved in DNA replication (GO:0006268)3.07351185
48positive regulation of B cell differentiation (GO:0045579)3.06687769
49regulation of superoxide anion generation (GO:0032928)3.04904434
50translational termination (GO:0006415)3.03271469
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98791397
52positive regulation of mast cell activation (GO:0033005)2.98088541
53negative regulation of phagocytosis (GO:0050765)2.97314854
54regulation of T cell tolerance induction (GO:0002664)2.93964116
55myeloid cell activation involved in immune response (GO:0002275)2.93750121
56amino sugar catabolic process (GO:0046348)2.91246958
57DNA replication initiation (GO:0006270)2.91035825
58translational elongation (GO:0006414)2.90581966
59regulation of B cell differentiation (GO:0045577)2.88437646
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86702985
61response to host immune response (GO:0052572)2.86702985
62negative regulation of cell killing (GO:0031342)2.85878616
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85878616
64B cell mediated immunity (GO:0019724)2.85731941
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84389916
66positive regulation of mast cell activation involved in immune response (GO:0033008)2.83096120
67positive regulation of mast cell degranulation (GO:0043306)2.83096120
68detection of biotic stimulus (GO:0009595)2.81518405
69glycosphingolipid catabolic process (GO:0046479)2.79724134
70positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.77610103
71response to muramyl dipeptide (GO:0032495)2.74661576
72positive regulation of leukocyte degranulation (GO:0043302)2.74429463
73myeloid dendritic cell differentiation (GO:0043011)2.74192286
74detection of molecule of bacterial origin (GO:0032490)2.73639393
75antigen processing and presentation via MHC class Ib (GO:0002475)2.73064222
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72857674
77response to host (GO:0075136)2.72857674
78response to host defenses (GO:0052200)2.72857674
79B cell receptor signaling pathway (GO:0050853)2.72476820
80heart contraction (GO:0060047)2.71817538
81heart process (GO:0003015)2.71817538
82actin nucleation (GO:0045010)2.69567084
83negative regulation of myeloid cell apoptotic process (GO:0033033)2.68728916
84telomere maintenance via recombination (GO:0000722)2.68640187
85regulation of interleukin-12 biosynthetic process (GO:0045075)2.67614632
86cellular response to thyroid hormone stimulus (GO:0097067)2.67505757
87regulation of relaxation of muscle (GO:1901077)2.67310389
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.65995204
89tricarboxylic acid cycle (GO:0006099)2.65556493
90T cell migration (GO:0072678)2.65230485
91negative regulation of leukocyte mediated immunity (GO:0002704)2.64920330
92regulation of regulated secretory pathway (GO:1903305)2.64906735
93myeloid dendritic cell activation (GO:0001773)2.64507326
94germinal center formation (GO:0002467)2.64274110
95regulation of defense response to virus by virus (GO:0050690)2.64035825
96positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.64009952
97regulation of mast cell activation (GO:0033003)2.63807045
98regulation of tolerance induction (GO:0002643)2.63183968
99negative thymic T cell selection (GO:0045060)2.62746926
100* barbed-end actin filament capping (GO:0051016)2.62587850
1013-UTR-mediated mRNA stabilization (GO:0070935)2.62249873
102formation of translation preinitiation complex (GO:0001731)2.61681271
103pinocytosis (GO:0006907)2.60567111
104negative T cell selection (GO:0043383)2.60203421
105respiratory burst (GO:0045730)2.58918991
106mannose metabolic process (GO:0006013)2.58862333
107type I interferon signaling pathway (GO:0060337)2.58700900
108cellular response to type I interferon (GO:0071357)2.58700900
109regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58632371
110regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.58412115
111regulation of response to interferon-gamma (GO:0060330)2.58370902
112cardiac myofibril assembly (GO:0055003)2.57483742
113negative regulation of innate immune response (GO:0045824)2.56753891
114myofibril assembly (GO:0030239)2.56664371
115regulation of antigen processing and presentation (GO:0002577)2.55786566
116actin-mediated cell contraction (GO:0070252)2.55615820
117thymic T cell selection (GO:0045061)2.54502044
118regulation of T-helper 2 cell differentiation (GO:0045628)2.54278197
119negative regulation of cytokine production involved in immune response (GO:0002719)2.53264892
120response to type I interferon (GO:0034340)2.52624284
121negative regulation of lymphocyte mediated immunity (GO:0002707)2.51975842
122regulation of dendritic cell antigen processing and presentation (GO:0002604)2.51509124
123cellular response to interferon-beta (GO:0035458)2.51247650
124interferon-gamma production (GO:0032609)2.50893141
125* positive regulation of lamellipodium assembly (GO:0010592)2.50770531
126positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49966036
127SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.49884209
128positive regulation of antigen processing and presentation (GO:0002579)2.49222965
129negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.48748968
130nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.48226684
131translational initiation (GO:0006413)2.47869020
132response to interleukin-15 (GO:0070672)2.46957190
133glycolipid catabolic process (GO:0019377)2.46710966
134macrophage activation (GO:0042116)2.45597632
135morphogenesis of an endothelium (GO:0003159)2.45320353
136endothelial tube morphogenesis (GO:0061154)2.45320353
137regulation of skeletal muscle contraction (GO:0014819)2.44686191
138regulation of necrotic cell death (GO:0010939)2.43966194
139regulation of interleukin-2 biosynthetic process (GO:0045076)2.43647679
140oxidative phosphorylation (GO:0006119)2.40583251
141maturation of SSU-rRNA (GO:0030490)2.40520731
142protein targeting to ER (GO:0045047)2.39590092
143ribosomal small subunit biogenesis (GO:0042274)2.39583332
144regulation of necroptotic process (GO:0060544)2.39545382
145mitotic recombination (GO:0006312)2.38278681
146cotranslational protein targeting to membrane (GO:0006613)2.38121017
147regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35566437
148viral life cycle (GO:0019058)2.34476741
149regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.34219589
150mast cell activation (GO:0045576)2.31662087
151telomere maintenance via telomere lengthening (GO:0010833)2.31338441
152cellular protein complex disassembly (GO:0043624)2.30900443
153T cell apoptotic process (GO:0070231)2.30601324
154positive T cell selection (GO:0043368)2.30402539
155establishment of protein localization to endoplasmic reticulum (GO:0072599)2.29880812
156NIK/NF-kappaB signaling (GO:0038061)2.29435879
157response to interferon-beta (GO:0035456)2.28750314
158cellular extravasation (GO:0045123)2.28684628
159DNA replication checkpoint (GO:0000076)2.27976205
160skeletal muscle contraction (GO:0003009)2.24059888
161response to peptidoglycan (GO:0032494)2.23524686
162sarcoplasmic reticulum calcium ion transport (GO:0070296)2.23356478
163negative regulation of necroptotic process (GO:0060546)2.23246415
164negative regulation of interleukin-12 production (GO:0032695)2.22329977
165protein localization to endoplasmic reticulum (GO:0070972)2.21661429
166neutrophil activation involved in immune response (GO:0002283)2.21180745
167interferon-gamma-mediated signaling pathway (GO:0060333)2.20897960
168T cell homeostasis (GO:0043029)2.20606712
169protein localization to kinetochore (GO:0034501)2.19983129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74925968
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44758014
3MYC_22102868_ChIP-Seq_BL_Human2.85053005
4VDR_21846776_ChIP-Seq_THP-1_Human2.56891560
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.52865181
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.48191373
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40034501
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.38586631
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.36356074
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34871348
11* LXR_22292898_ChIP-Seq_THP-1_Human2.29838546
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29731916
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27959045
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.22778178
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.22130157
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18132871
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07120915
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05150900
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04191851
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02500627
21* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97978471
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97789664
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95340221
24* MAF_26560356_Chip-Seq_TH1_Human1.94260701
25SPI1_23547873_ChIP-Seq_NB4_Human1.92289945
26SCL_19346495_ChIP-Seq_HPC-7_Human1.86731191
27CIITA_25753668_ChIP-Seq_RAJI_Human1.82626234
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82058336
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80516256
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78586885
31UTX_26944678_Chip-Seq_JUKART_Human1.75284179
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74864769
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73541342
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71372828
35MYB_26560356_Chip-Seq_TH2_Human1.69976163
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68373641
37* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67941933
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.67002448
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66986243
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65464571
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63610804
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.61743107
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.59041234
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58991368
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.58479839
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58225872
47XRN2_22483619_ChIP-Seq_HELA_Human1.57854571
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55854201
49* TCF7_22412390_ChIP-Seq_EML_Mouse1.55540774
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53263334
51VDR_23849224_ChIP-Seq_CD4+_Human1.53110467
52VDR_24763502_ChIP-Seq_THP-1_Human1.51973992
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49920860
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49361667
55MYB_26560356_Chip-Seq_TH1_Human1.46036406
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45736129
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45235764
58RACK7_27058665_Chip-Seq_MCF-7_Human1.44273857
59FOXP3_21729870_ChIP-Seq_TREG_Human1.42924689
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42235570
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41912285
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40468299
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39609105
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38398138
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38071558
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.37927867
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.37843149
68SPI1_23127762_ChIP-Seq_K562_Human1.37512411
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.36569826
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36230665
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35181562
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35015909
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35002091
74* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34697891
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34054095
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33824992
77* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33723373
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33573963
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32774393
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31374679
81* MAF_26560356_Chip-Seq_TH2_Human1.31216373
82BCOR_27268052_Chip-Seq_Bcells_Human1.30731533
83FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30247836
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29725541
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28484313
86* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28479565
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.28475485
88P68_20966046_ChIP-Seq_HELA_Human1.27569896
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25960595
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25107776
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24564667
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23260693
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.22991091
94KDM2B_26808549_Chip-Seq_DND41_Human1.22940556
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22171765
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21658836
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21082298
98* GABP_19822575_ChIP-Seq_HepG2_Human1.20469171
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.20460311
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20323914
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.18957087
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17704597
103* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17195607
104DCP1A_22483619_ChIP-Seq_HELA_Human1.16458515
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15724122
106* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15163757
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.15080591
108NCOR1_26117541_ChIP-Seq_K562_Human1.14377227
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13817510
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13043465
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12410363
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12218912
113STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11943420
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11042159
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10930135
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10598364
117RUNX_20019798_ChIP-Seq_JUKART_Human1.10359985
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10357865
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10349383
120* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09999483
121* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09291972
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09281066
123TFEB_21752829_ChIP-Seq_HELA_Human1.09177580
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06835189
125CTCF_26484167_Chip-Seq_Bcells_Mouse1.06677143
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05788548
127SRF_21415370_ChIP-Seq_HL-1_Mouse1.05475373
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04632629
129KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04468192
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03606388
131KDM2B_26808549_Chip-Seq_JURKAT_Human1.03363845
132SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03029548
133ZNF263_19887448_ChIP-Seq_K562_Human1.02420424
134ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01890355
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01241403
136BCL6_27268052_Chip-Seq_Bcells_Human1.01130752
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99957704
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99750598
139TTF2_22483619_ChIP-Seq_HELA_Human0.99304949
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98698563
141CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98238943
142* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96931062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.54155091
2MP0001835_abnormal_antigen_presentation2.98009484
3MP0002837_dystrophic_cardiac_calcinosis2.85536046
4MP0005451_abnormal_body_composition2.78617050
5MP0002396_abnormal_hematopoietic_system2.59022053
6MP0004084_abnormal_cardiac_muscle2.57408769
7MP0003763_abnormal_thymus_physiology2.50897779
8MP0000751_myopathy2.44426241
9MP0009840_abnormal_foam_cell2.43017244
10MP0005671_abnormal_response_to2.40404881
11MP0008260_abnormal_autophagy2.35324578
12MP0000685_abnormal_immune_system2.32319707
13MP0003436_decreased_susceptibility_to2.23416972
14MP0009785_altered_susceptibility_to2.21616788
15MP0003303_peritoneal_inflammation2.18594368
16MP0000749_muscle_degeneration2.16849241
17MP0001800_abnormal_humoral_immune2.05291652
18MP0002398_abnormal_bone_marrow1.97253306
19MP0002420_abnormal_adaptive_immunity1.97076170
20MP0001819_abnormal_immune_cell1.95654056
21MP0005000_abnormal_immune_tolerance1.94206901
22MP0003693_abnormal_embryo_hatching1.93334887
23MP0002452_abnormal_antigen_presenting1.92723065
24MP0005025_abnormal_response_to1.92409609
25MP0004036_abnormal_muscle_relaxation1.89875832
26MP0001853_heart_inflammation1.84077395
27MP0003075_altered_response_to1.83809663
28MP0004510_myositis1.82685606
29MP0005330_cardiomyopathy1.81845714
30MP0002723_abnormal_immune_serum1.81416101
31MP0003806_abnormal_nucleotide_metabolis1.80561260
32MP0009333_abnormal_splenocyte_physiolog1.79823256
33MP0002419_abnormal_innate_immunity1.77602734
34MP0000343_altered_response_to1.77053345
35MP0000750_abnormal_muscle_regeneration1.76105244
36MP0004087_abnormal_muscle_fiber1.73541448
37MP0002148_abnormal_hypersensitivity_rea1.73483578
38MP0004215_abnormal_myocardial_fiber1.72393165
39MP0005387_immune_system_phenotype1.72329851
40MP0001790_abnormal_immune_system1.72329851
41MP0004808_abnormal_hematopoietic_stem1.70426977
42MP0000716_abnormal_immune_system1.69650679
43MP0003828_pulmonary_edema1.67891801
44MP0002722_abnormal_immune_system1.65991556
45MP0000689_abnormal_spleen_morphology1.65506611
46MP0003077_abnormal_cell_cycle1.65309207
47MP0002106_abnormal_muscle_physiology1.65155878
48MP0002405_respiratory_system_inflammati1.62620820
49MP0003221_abnormal_cardiomyocyte_apopto1.61519021
50MP0010094_abnormal_chromosome_stability1.58812346
51MP0004957_abnormal_blastocyst_morpholog1.54595262
52MP0002429_abnormal_blood_cell1.53797921
53MP0000703_abnormal_thymus_morphology1.53462890
54MP0002998_abnormal_bone_remodeling1.51588532
55MP0005464_abnormal_platelet_physiology1.48994349
56MP0002269_muscular_atrophy1.48965880
57MP0000604_amyloidosis1.48009421
58MP0003705_abnormal_hypodermis_morpholog1.47996479
59MP0010630_abnormal_cardiac_muscle1.47907764
60MP0002166_altered_tumor_susceptibility1.46127932
61MP0001545_abnormal_hematopoietic_system1.43898740
62MP0005397_hematopoietic_system_phenotyp1.43898740
63MP0009278_abnormal_bone_marrow1.42999225
64MP0010352_gastrointestinal_tract_polyps1.40418157
65MP0000490_abnormal_crypts_of1.40241380
66MP0003111_abnormal_nucleus_morphology1.39467214
67MP0004145_abnormal_muscle_electrophysio1.38189507
68MP0004130_abnormal_muscle_cell1.33447041
69MP0001544_abnormal_cardiovascular_syste1.33066150
70MP0005385_cardiovascular_system_phenoty1.33066150
71MP0006036_abnormal_mitochondrial_physio1.33030607
72MP0010155_abnormal_intestine_physiology1.32163994
73MP0003279_aneurysm1.31821720
74MP0001873_stomach_inflammation1.31353314
75MP0000759_abnormal_skeletal_muscle1.31038989
76MP0000747_muscle_weakness1.29415293
77MP0009764_decreased_sensitivity_to1.27499824
78MP0000858_altered_metastatic_potential1.26651374
79MP0000465_gastrointestinal_hemorrhage1.25694374
80MP0005166_decreased_susceptibility_to1.25176068
81MP0002972_abnormal_cardiac_muscle1.22031914
82MP0002877_abnormal_melanocyte_morpholog1.21925509
83MP0008057_abnormal_DNA_replication1.20214950
84MP0001845_abnormal_inflammatory_respons1.15899163
85MP0002006_tumorigenesis1.13740402
86MP0006082_CNS_inflammation1.12637922
87MP0002019_abnormal_tumor_incidence1.12497236
88MP0005369_muscle_phenotype1.11668223
89MP0003566_abnormal_cell_adhesion1.09582457
90MP0005620_abnormal_muscle_contractility1.04155997
91MP0008058_abnormal_DNA_repair1.03627669
92MP0005058_abnormal_lysosome_morphology1.02682949
93MP0008007_abnormal_cellular_replicative1.01966129
94MP0008004_abnormal_stomach_pH1.01759505
95MP0003724_increased_susceptibility_to1.01295457
96MP0004484_altered_response_of1.01006548
97MP0001849_ear_inflammation0.99569777
98MP0008775_abnormal_heart_ventricle0.98787661
99MP0003567_abnormal_fetal_cardiomyocyte0.98667236
100MP0003448_altered_tumor_morphology0.98133266
101MP0005165_increased_susceptibility_to0.96150494
102MP0005390_skeleton_phenotype0.96080646
103MP0003866_abnormal_defecation0.95928371
104MP0008438_abnormal_cutaneous_collagen0.95367143
105MP0003183_abnormal_peptide_metabolism0.95056441
106MP0001851_eye_inflammation0.94531859
107MP0002132_abnormal_respiratory_system0.94120520
108MP0010307_abnormal_tumor_latency0.92499817
109MP0003172_abnormal_lysosome_physiology0.92441959
110MP0001533_abnormal_skeleton_physiology0.92360635
111MP0003329_amyloid_beta_deposits0.92227925
112MP0003300_gastrointestinal_ulcer0.92102333
113MP0003191_abnormal_cellular_cholesterol0.90742473
114MP0003453_abnormal_keratinocyte_physiol0.90684124
115MP0003091_abnormal_cell_migration0.89693259
116MP0006054_spinal_hemorrhage0.89322510
117MP0005310_abnormal_salivary_gland0.89037692
118MP0008469_abnormal_protein_level0.87981145
119MP0004947_skin_inflammation0.87468374
120MP0004858_abnormal_nervous_system0.86317394
121MP0001730_embryonic_growth_arrest0.86242702
122MP0009763_increased_sensitivity_to0.86111941
123MP0000313_abnormal_cell_death0.85581873
124MP0000350_abnormal_cell_proliferation0.84597605
125MP0003795_abnormal_bone_structure0.82889542
126MP0000249_abnormal_blood_vessel0.82876203
127MP0008874_decreased_physiological_sensi0.81011931
128MP0004233_abnormal_muscle_weight0.80786507
129MP0005023_abnormal_wound_healing0.80750240
130MP0002332_abnormal_exercise_endurance0.80170696
131MP0001958_emphysema0.77462420
132MP0005164_abnormal_response_to0.77058839
133MP0002933_joint_inflammation0.76567879
134MP0003656_abnormal_erythrocyte_physiolo0.75237948
135MP0004185_abnormal_adipocyte_glucose0.74749744
136MP0004883_abnormal_blood_vessel0.74270191
137MP0001542_abnormal_bone_strength0.73825583

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)4.29746800
2Abnormality of glycolipid metabolism (HP:0010969)4.29631422
3Abnormality of liposaccharide metabolism (HP:0010968)4.29631422
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.29631422
5Recurrent abscess formation (HP:0002722)4.04635451
6Muscle fiber inclusion bodies (HP:0100299)3.98316736
7Ventricular tachycardia (HP:0004756)3.93527015
8Exercise-induced myalgia (HP:0003738)3.86078600
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.78133983
10Elevated erythrocyte sedimentation rate (HP:0003565)3.74542394
11Eczematoid dermatitis (HP:0000976)3.69851531
12Calf muscle hypertrophy (HP:0008981)3.59683976
13Sudden death (HP:0001699)3.51917168
14Nemaline bodies (HP:0003798)3.50552897
15IgM deficiency (HP:0002850)3.49739682
16Muscle hypertrophy of the lower extremities (HP:0008968)3.39601595
17Myoglobinuria (HP:0002913)3.38992321
18Rhabdomyolysis (HP:0003201)3.24529100
19Subaortic stenosis (HP:0001682)3.21499473
20Abnormality of the left ventricular outflow tract (HP:0011103)3.21499473
21Asymmetric septal hypertrophy (HP:0001670)3.14935626
22Muscle fiber splitting (HP:0003555)3.09223091
23Purpura (HP:0000979)3.08530091
24Thrombocytosis (HP:0001894)3.05031269
25Recurrent bacterial skin infections (HP:0005406)3.03793263
26Vacuolated lymphocytes (HP:0001922)3.03702490
27Dysostosis multiplex (HP:0000943)3.03694502
28Myositis (HP:0100614)2.94908734
29Systemic lupus erythematosus (HP:0002725)2.86152813
30Recurrent fungal infections (HP:0002841)2.85609135
31Loss of speech (HP:0002371)2.84564133
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.82215580
33EMG: myopathic abnormalities (HP:0003458)2.79026976
34Recurrent viral infections (HP:0004429)2.78572923
35Chronic otitis media (HP:0000389)2.74583195
36Lipoatrophy (HP:0100578)2.74516272
37Orchitis (HP:0100796)2.71064097
38Ulnar deviation of the wrist (HP:0003049)2.65091163
39Amyloidosis (HP:0011034)2.65039140
40Hepatosplenomegaly (HP:0001433)2.64949016
41Progressive muscle weakness (HP:0003323)2.57709247
42Abnormality of the nasal mucosa (HP:0000433)2.57663221
43Vertebral compression fractures (HP:0002953)2.57497495
44Spontaneous hematomas (HP:0007420)2.56685940
45Type 1 muscle fiber predominance (HP:0003803)2.56202548
46Abnormality of T cells (HP:0002843)2.53552653
47Recurrent bronchitis (HP:0002837)2.52061773
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.50251924
49Abnormality of T cell physiology (HP:0011840)2.50017805
50Prolonged bleeding time (HP:0003010)2.49945250
51Difficulty running (HP:0009046)2.49412069
52Increased serum ferritin (HP:0003281)2.49340786
53Epistaxis (HP:0000421)2.47051913
54Obstructive lung disease (HP:0006536)2.46034047
55Chronic obstructive pulmonary disease (HP:0006510)2.46034047
56Upper motor neuron abnormality (HP:0002127)2.44431525
57Panhypogammaglobulinemia (HP:0003139)2.44202636
58Myopathic facies (HP:0002058)2.43389095
59Hyporeflexia of lower limbs (HP:0002600)2.42774669
60Increased connective tissue (HP:0009025)2.42195102
61Frequent falls (HP:0002359)2.41940568
62Axonal loss (HP:0003447)2.41364476
63Abnormality of the calf musculature (HP:0001430)2.40400852
64Gingivitis (HP:0000230)2.39322420
65Areflexia of lower limbs (HP:0002522)2.37476314
66Urticaria (HP:0001025)2.37086532
67Agnosia (HP:0010524)2.36769733
68Multiple enchondromatosis (HP:0005701)2.36580603
69Supraventricular tachycardia (HP:0004755)2.36420595
70Chest pain (HP:0100749)2.35459805
71Cellulitis (HP:0100658)2.35135968
72Mediastinal lymphadenopathy (HP:0100721)2.34865129
73Nasal polyposis (HP:0100582)2.34672068
74Atrial fibrillation (HP:0005110)2.33802445
75Supraventricular arrhythmia (HP:0005115)2.30265683
76Gastrointestinal inflammation (HP:0004386)2.29266339
77Distal arthrogryposis (HP:0005684)2.27653956
78Meningitis (HP:0001287)2.26182747
79Abnormality of polysaccharide metabolism (HP:0011012)2.24682690
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24682690
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24682690
82Myocardial infarction (HP:0001658)2.24056559
83Primary atrial arrhythmia (HP:0001692)2.23945457
84Dilated cardiomyopathy (HP:0001644)2.23642582
85Abnormality of macrophages (HP:0004311)2.23547317
86Centrally nucleated skeletal muscle fibers (HP:0003687)2.22529203
87Pustule (HP:0200039)2.21004252
88Inflammation of the large intestine (HP:0002037)2.20887332
89Gastrointestinal infarctions (HP:0005244)2.18792345
90Difficulty climbing stairs (HP:0003551)2.17905086
91Hypertensive crisis (HP:0100735)2.17071353
92Abnormality of cells of the erythroid lineage (HP:0012130)2.16566504
93Bundle branch block (HP:0011710)2.16406880
94Myotonia (HP:0002486)2.14551521
95Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14441518
96Facial diplegia (HP:0001349)2.14043929
97Abnormal number of erythroid precursors (HP:0012131)2.14041978
98Distal lower limb amyotrophy (HP:0008944)2.13513075
99Increased IgM level (HP:0003496)2.12999230
100Retrobulbar optic neuritis (HP:0100654)2.11978447
101Optic neuritis (HP:0100653)2.11978447
102Recurrent cutaneous fungal infections (HP:0011370)2.11641112
103Chronic mucocutaneous candidiasis (HP:0002728)2.11641112
104Palpitations (HP:0001962)2.09916596
105Ragged-red muscle fibers (HP:0003200)2.09358819
106Petechiae (HP:0000967)2.09152479
107Mucopolysacchariduria (HP:0008155)2.08711082
108Urinary glycosaminoglycan excretion (HP:0003541)2.08711082
109Increased variability in muscle fiber diameter (HP:0003557)2.08156466
110T lymphocytopenia (HP:0005403)2.04859554
111Progressive neurologic deterioration (HP:0002344)2.04319190
112Bulbar palsy (HP:0001283)2.03544522
113Recurrent skin infections (HP:0001581)2.03396889
114Limb-girdle muscle atrophy (HP:0003797)2.03067297
115Disinhibition (HP:0000734)2.02860237
116Reticulocytopenia (HP:0001896)2.01805914
117Gingival bleeding (HP:0000225)2.01798070
118Vasculitis (HP:0002633)2.01712695
119Abnormality of cells of the lymphoid lineage (HP:0012140)2.01386485
120Distal lower limb muscle weakness (HP:0009053)1.99856916
121Lymphopenia (HP:0001888)1.99790160
122Neck muscle weakness (HP:0000467)1.99167368
123Encephalitis (HP:0002383)1.98594455
124Muscle stiffness (HP:0003552)1.97107878
125Abnormality of skeletal muscle fiber size (HP:0012084)1.94891279
126Abnormality of T cell number (HP:0011839)1.94265095
127Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94000250
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94000250
129Recurrent gram-negative bacterial infections (HP:0005420)1.92738915
130Abnormality of iron homeostasis (HP:0011031)1.92295686
131Achilles tendon contracture (HP:0001771)1.89328752
132Colitis (HP:0002583)1.87773088
133Abnormal platelet volume (HP:0011876)1.87081576
134Pulmonary infiltrates (HP:0002113)1.84260931
135Hypergammaglobulinemia (HP:0010702)1.83663642
136Abnormal platelet function (HP:0011869)1.81436130
137Impaired platelet aggregation (HP:0003540)1.81436130
138Increased IgE level (HP:0003212)1.81433183
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80852888
140Hypertriglyceridemia (HP:0002155)1.80657194
141Polygenic inheritance (HP:0010982)1.80515045
142Episodic fever (HP:0001954)1.79315398
143Gastrointestinal stroma tumor (HP:0100723)1.79232616
144Birth length less than 3rd percentile (HP:0003561)1.78963345
145Amaurosis fugax (HP:0100576)1.78910668
146Fatigue (HP:0012378)1.78354673
147Stomatitis (HP:0010280)1.76999328
148Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76551088
149Increased cerebral lipofuscin (HP:0011813)1.75809376
150Autoimmune thrombocytopenia (HP:0001973)1.75589822
151Calcaneovalgus deformity (HP:0001848)1.75240700
152Papilloma (HP:0012740)1.74839598
153Verrucae (HP:0200043)1.74839598
154Hepatic necrosis (HP:0002605)1.74630513
155Neuronal loss in central nervous system (HP:0002529)1.74541807
156Polycythemia (HP:0001901)1.73915862
157Eosinophilia (HP:0001880)1.72466258
158Neoplasm of head and neck (HP:0012288)1.72145198
159Abnormality of the Achilles tendon (HP:0005109)1.71445850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.90098075
2TTN3.78391692
3PKN22.94716692
4PRPF4B2.81023634
5OBSCN2.46881195
6IRAK32.36149049
7TRIB32.34583609
8MAP2K32.15774384
9EEF2K2.15223886
10SMG12.09654012
11TYK22.08276003
12NME22.03514878
13FLT32.01829392
14TESK11.98046982
15ZAP701.90776085
16BLK1.89679108
17KIT1.89654145
18NEK11.88446348
19BTK1.84128529
20STK101.83219694
21IRAK41.82208428
22KDR1.78715782
23TXK1.73257981
24TESK21.61838020
25JAK31.60964601
26BUB11.59138617
27ERN11.57312872
28TBK11.53050752
29ARAF1.52410796
30WEE11.47748076
31MAP3K131.45131473
32MAP3K141.43765447
33TGFBR21.43066094
34MAP3K101.41218165
35TEC1.39958985
36CSF1R1.39639237
37MAPKAPK31.38364569
38BCKDK1.34781681
39ITK1.31176682
40GRK61.29288669
41LRRK21.28924591
42MAP3K111.22323481
43EPHB11.21572968
44FGR1.20057094
45ICK1.19219459
46PAK41.18151991
47LIMK11.18104812
48SYK1.14846094
49MAP3K11.13417757
50PHKG21.09173406
51PHKG11.09173406
52NEK21.08140931
53RPS6KA41.07928187
54IKBKE1.06993766
55TNK21.06439483
56SCYL21.06041896
57STK41.03360321
58MYLK1.02254243
59TGFBR11.01940721
60CDC71.01394704
61SIK11.01125967
62MOS1.00435436
63CLK10.99684253
64RPS6KB20.99035129
65DMPK0.97891096
66PDK30.94875921
67PDK40.94875921
68HCK0.94705174
69PIM10.92213449
70LCK0.89656101
71MUSK0.88594911
72PRKD20.88178082
73CDC42BPA0.85952684
74CDK40.85347335
75CSK0.83689916
76ILK0.82941436
77ABL20.80705687
78PIM20.80063387
79JAK10.79307249
80FES0.78714550
81MAP3K80.76621269
82SIK30.75323825
83TRPM70.73937214
84EIF2AK10.73144987
85PDPK10.72269724
86MAP3K60.71674221
87KSR20.71438954
88STK240.71404025
89MATK0.71163651
90PTK60.66569725
91PIK3CG0.65987079
92LYN0.65306550
93MARK20.65181642
94VRK20.64391633
95BMX0.62772566
96PRKG20.62723173
97IKBKB0.62257357
98FGFR40.61312925
99CAMKK20.60580854
100TIE10.60577914
101PDK10.57781193
102RIPK10.57363737
103RPS6KA60.56148241
104RIPK40.55324542
105TAOK10.54940332
106MAPK120.54723734
107MAP3K30.53980533
108TSSK60.53306740
109CDK70.52829328
110MAPK110.51871778
111CDK190.51590523
112RPS6KL10.51137128
113RPS6KC10.51137128
114TAOK20.50966759
115RPS6KA20.50782418
116ATR0.50670392
117DAPK30.50344505
118IRAK20.50046276
119PAK10.49079957
120BRAF0.49074032
121PDK20.48556462
122JAK20.48336008
123ALK0.48131774
124PASK0.47084193
125NLK0.47025621
126DAPK10.46153536
127ACVR1B0.46062411
128MAP2K60.44739370
129MARK30.43893998
130TLK10.43617828
131LMTK20.43547214
132CAMKK10.41962550
133MAPKAPK20.40900422
134MAP3K70.40479053
135DYRK1B0.40139477
136MAP3K50.40108368
137GRK70.39452740
138FGFR30.39021301
139MAPK40.39000436
140MAPK70.38126499
141FYN0.37545363
142VRK10.37530741
143RAF10.36859059
144HIPK20.34965108

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.53155045
2Mismatch repair_Homo sapiens_hsa034302.63397627
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.62745954
4Primary immunodeficiency_Homo sapiens_hsa053402.50812817
5Ribosome_Homo sapiens_hsa030102.46476968
6Staphylococcus aureus infection_Homo sapiens_hsa051502.44216088
7Lysosome_Homo sapiens_hsa041422.24383946
8Base excision repair_Homo sapiens_hsa034102.23326669
9Leishmaniasis_Homo sapiens_hsa051402.03035629
10Antigen processing and presentation_Homo sapiens_hsa046121.94427453
11Autoimmune thyroid disease_Homo sapiens_hsa053201.94216969
12Viral myocarditis_Homo sapiens_hsa054161.90448766
13Proteasome_Homo sapiens_hsa030501.71622086
14Spliceosome_Homo sapiens_hsa030401.69094679
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68061679
16Phagosome_Homo sapiens_hsa041451.65178861
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64262564
18B cell receptor signaling pathway_Homo sapiens_hsa046621.59358917
19Rheumatoid arthritis_Homo sapiens_hsa053231.55363782
20Measles_Homo sapiens_hsa051621.50411916
21Malaria_Homo sapiens_hsa051441.48841145
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45200838
23Osteoclast differentiation_Homo sapiens_hsa043801.44922994
24Legionellosis_Homo sapiens_hsa051341.41348324
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39242266
26Herpes simplex infection_Homo sapiens_hsa051681.38724001
27Asthma_Homo sapiens_hsa053101.37648394
28Nucleotide excision repair_Homo sapiens_hsa034201.31626300
29Type I diabetes mellitus_Homo sapiens_hsa049401.31625660
30Homologous recombination_Homo sapiens_hsa034401.31562210
31RNA transport_Homo sapiens_hsa030131.25878600
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.25171423
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25091694
34Shigellosis_Homo sapiens_hsa051311.24954931
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21209579
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.19624309
37Cell cycle_Homo sapiens_hsa041101.18988167
38T cell receptor signaling pathway_Homo sapiens_hsa046601.18025035
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17873397
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.16888895
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16654792
42Other glycan degradation_Homo sapiens_hsa005111.16288016
43Non-homologous end-joining_Homo sapiens_hsa034501.16016425
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15144973
45Acute myeloid leukemia_Homo sapiens_hsa052211.14606176
46Dilated cardiomyopathy_Homo sapiens_hsa054141.13758347
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12709108
48Pyrimidine metabolism_Homo sapiens_hsa002401.10673835
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09171037
50RNA polymerase_Homo sapiens_hsa030201.08697484
51Epstein-Barr virus infection_Homo sapiens_hsa051691.08579997
52Hematopoietic cell lineage_Homo sapiens_hsa046401.06525444
53Cardiac muscle contraction_Homo sapiens_hsa042601.04807017
54Toxoplasmosis_Homo sapiens_hsa051451.04300083
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03614883
56Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02926285
57Apoptosis_Homo sapiens_hsa042101.01608430
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00529537
59Carbon metabolism_Homo sapiens_hsa012001.00334225
60Fructose and mannose metabolism_Homo sapiens_hsa000510.99862835
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.98223747
62Endocytosis_Homo sapiens_hsa041440.95627203
63Tuberculosis_Homo sapiens_hsa051520.95226699
64Influenza A_Homo sapiens_hsa051640.94470826
65Bladder cancer_Homo sapiens_hsa052190.94385414
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92701489
67Parkinsons disease_Homo sapiens_hsa050120.92642488
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91602910
69Salmonella infection_Homo sapiens_hsa051320.91439275
70Pertussis_Homo sapiens_hsa051330.90683511
71RNA degradation_Homo sapiens_hsa030180.90675624
72Platelet activation_Homo sapiens_hsa046110.89563529
73Pentose phosphate pathway_Homo sapiens_hsa000300.88606478
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88086672
75Graft-versus-host disease_Homo sapiens_hsa053320.87778750
76HTLV-I infection_Homo sapiens_hsa051660.86156154
77Hepatitis B_Homo sapiens_hsa051610.85756781
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83300912
79Prion diseases_Homo sapiens_hsa050200.83186811
80HIF-1 signaling pathway_Homo sapiens_hsa040660.82869533
81VEGF signaling pathway_Homo sapiens_hsa043700.81680715
82p53 signaling pathway_Homo sapiens_hsa041150.80391341
83Viral carcinogenesis_Homo sapiens_hsa052030.79521393
84Galactose metabolism_Homo sapiens_hsa000520.79494630
85Allograft rejection_Homo sapiens_hsa053300.78089896
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76916373
87Hepatitis C_Homo sapiens_hsa051600.76344143
88Vibrio cholerae infection_Homo sapiens_hsa051100.76198084
89Amoebiasis_Homo sapiens_hsa051460.75605089
90Chronic myeloid leukemia_Homo sapiens_hsa052200.74088440
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.73207022
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72310654
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.71363495
94Chemokine signaling pathway_Homo sapiens_hsa040620.69488575
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68538155
96Sulfur relay system_Homo sapiens_hsa041220.67004666
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.63296332
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62332066
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.59088060
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57461276
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57241587
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56893770
103Insulin resistance_Homo sapiens_hsa049310.56479363
104Colorectal cancer_Homo sapiens_hsa052100.56356548
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55557823
106Pancreatic cancer_Homo sapiens_hsa052120.55448122
107Sulfur metabolism_Homo sapiens_hsa009200.55447622
108Thyroid cancer_Homo sapiens_hsa052160.55340110
109Collecting duct acid secretion_Homo sapiens_hsa049660.55011011
110Biosynthesis of amino acids_Homo sapiens_hsa012300.54405235
111African trypanosomiasis_Homo sapiens_hsa051430.53095293
112Purine metabolism_Homo sapiens_hsa002300.52725329
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52320649
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52201685
115Non-small cell lung cancer_Homo sapiens_hsa052230.52068376
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51300136
117One carbon pool by folate_Homo sapiens_hsa006700.51227306
118Notch signaling pathway_Homo sapiens_hsa043300.50470960
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.50423041
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50225924
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49725235
122Fanconi anemia pathway_Homo sapiens_hsa034600.49421870
123Oxidative phosphorylation_Homo sapiens_hsa001900.48848899
124TNF signaling pathway_Homo sapiens_hsa046680.48734626
125Insulin signaling pathway_Homo sapiens_hsa049100.48442346
126Huntingtons disease_Homo sapiens_hsa050160.46724152
127Small cell lung cancer_Homo sapiens_hsa052220.46624104
128mRNA surveillance pathway_Homo sapiens_hsa030150.46232606
129GnRH signaling pathway_Homo sapiens_hsa049120.39588050
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.38905081
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38819123
132Renal cell carcinoma_Homo sapiens_hsa052110.37152827
133Prolactin signaling pathway_Homo sapiens_hsa049170.35846258
134Focal adhesion_Homo sapiens_hsa045100.35396076

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