

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.32329741 |
| 2 | DNA deamination (GO:0045006) | 5.07819723 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 4.67865675 |
| 4 | viral transcription (GO:0019083) | 4.55273821 |
| 5 | positive regulation of glycoprotein biosynthetic process (GO:0010560) | 4.52379205 |
| 6 | translational termination (GO:0006415) | 4.47349574 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 4.38438107 |
| 8 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.18930956 |
| 9 | ribosomal large subunit biogenesis (GO:0042273) | 4.18168411 |
| 10 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.17452505 |
| 11 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.16245100 |
| 12 | chaperone-mediated protein transport (GO:0072321) | 4.15739763 |
| 13 | DNA strand elongation (GO:0022616) | 4.01445963 |
| 14 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.98658059 |
| 15 | DNA replication initiation (GO:0006270) | 3.98564471 |
| 16 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.97882281 |
| 17 | translational elongation (GO:0006414) | 3.95162949 |
| 18 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.93639927 |
| 19 | nucleobase biosynthetic process (GO:0046112) | 3.89640609 |
| 20 | cotranslational protein targeting to membrane (GO:0006613) | 3.87589926 |
| 21 | telomere maintenance via recombination (GO:0000722) | 3.85885234 |
| 22 | CENP-A containing nucleosome assembly (GO:0034080) | 3.85136551 |
| 23 | protein targeting to ER (GO:0045047) | 3.85048768 |
| 24 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.81591441 |
| 25 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.81591441 |
| 26 | NADH dehydrogenase complex assembly (GO:0010257) | 3.81591441 |
| 27 | formation of translation preinitiation complex (GO:0001731) | 3.79892041 |
| 28 | purine nucleobase biosynthetic process (GO:0009113) | 3.79588627 |
| 29 | translational initiation (GO:0006413) | 3.79578890 |
| 30 | chromatin remodeling at centromere (GO:0031055) | 3.77459861 |
| 31 | replication fork processing (GO:0031297) | 3.65062657 |
| 32 | regulation of protein glycosylation (GO:0060049) | 3.64867805 |
| 33 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.64491224 |
| 34 | protein heterotetramerization (GO:0051290) | 3.64197249 |
| 35 | protein localization to endoplasmic reticulum (GO:0070972) | 3.63895945 |
| 36 | ribosome biogenesis (GO:0042254) | 3.63783473 |
| 37 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.62217110 |
| 38 | pseudouridine synthesis (GO:0001522) | 3.61627826 |
| 39 | mitotic recombination (GO:0006312) | 3.59982509 |
| 40 | kinetochore organization (GO:0051383) | 3.58133181 |
| 41 | spermatid nucleus differentiation (GO:0007289) | 3.57960041 |
| 42 | positive regulation of glycoprotein metabolic process (GO:1903020) | 3.56694694 |
| 43 | protein localization to kinetochore (GO:0034501) | 3.51632206 |
| 44 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.50061311 |
| 45 | ribosome assembly (GO:0042255) | 3.48505312 |
| 46 | * transcription from RNA polymerase I promoter (GO:0006360) | 3.48362151 |
| 47 | viral life cycle (GO:0019058) | 3.45633785 |
| 48 | protein complex biogenesis (GO:0070271) | 3.45609952 |
| 49 | DNA replication checkpoint (GO:0000076) | 3.43089100 |
| 50 | rRNA processing (GO:0006364) | 3.42648954 |
| 51 | telomere maintenance via telomere lengthening (GO:0010833) | 3.41717517 |
| 52 | ubiquinone biosynthetic process (GO:0006744) | 3.41576132 |
| 53 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.39321913 |
| 54 | DNA replication-independent nucleosome organization (GO:0034724) | 3.39321913 |
| 55 | cellular protein complex disassembly (GO:0043624) | 3.39199799 |
| 56 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.38599457 |
| 57 | DNA damage response, detection of DNA damage (GO:0042769) | 3.38367445 |
| 58 | DNA unwinding involved in DNA replication (GO:0006268) | 3.37411412 |
| 59 | proteasome assembly (GO:0043248) | 3.34200427 |
| 60 | rRNA metabolic process (GO:0016072) | 3.31168840 |
| 61 | regulation of helicase activity (GO:0051095) | 3.30728815 |
| 62 | kinetochore assembly (GO:0051382) | 3.30639987 |
| 63 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.24784157 |
| 64 | ATP synthesis coupled proton transport (GO:0015986) | 3.24784157 |
| 65 | IMP biosynthetic process (GO:0006188) | 3.24137298 |
| 66 | termination of RNA polymerase III transcription (GO:0006386) | 3.23580035 |
| 67 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.23580035 |
| 68 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.21630060 |
| 69 | protein deneddylation (GO:0000338) | 3.21571156 |
| 70 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.17447903 |
| 71 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.17220541 |
| 72 | translation (GO:0006412) | 3.15814065 |
| 73 | spliceosomal snRNP assembly (GO:0000387) | 3.14456394 |
| 74 | telomere maintenance via telomerase (GO:0007004) | 3.13150142 |
| 75 | maturation of 5.8S rRNA (GO:0000460) | 3.12861494 |
| 76 | ubiquinone metabolic process (GO:0006743) | 3.11758632 |
| 77 | cell fate commitment involved in formation of primary germ layer (GO:0060795) | 3.10495514 |
| 78 | ncRNA 3-end processing (GO:0043628) | 3.10474752 |
| 79 | negative regulation of ligase activity (GO:0051352) | 3.08452189 |
| 80 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.08452189 |
| 81 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.07403595 |
| 82 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.07077640 |
| 83 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.06872415 |
| 84 | histone exchange (GO:0043486) | 3.04558722 |
| 85 | negative regulation of execution phase of apoptosis (GO:1900118) | 3.04103125 |
| 86 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.03272423 |
| 87 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.02768405 |
| 88 | cellular component biogenesis (GO:0044085) | 3.01871928 |
| 89 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.99882435 |
| 90 | mitotic nuclear envelope disassembly (GO:0007077) | 2.99792556 |
| 91 | protein complex disassembly (GO:0043241) | 2.98796247 |
| 92 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.98437641 |
| 93 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.98437641 |
| 94 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.98225485 |
| 95 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.97009421 |
| 96 | isotype switching (GO:0045190) | 2.97009421 |
| 97 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.97009421 |
| 98 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.96990990 |
| 99 | protein localization to chromosome, centromeric region (GO:0071459) | 2.96559320 |
| 100 | mitotic metaphase plate congression (GO:0007080) | 2.95296361 |
| 101 | regulation of centriole replication (GO:0046599) | 2.94210979 |
| 102 | histone H2B ubiquitination (GO:0033523) | 2.94167495 |
| 103 | termination of RNA polymerase I transcription (GO:0006363) | 2.92070661 |
| 104 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.91055494 |
| 105 | DNA-templated transcription, termination (GO:0006353) | 2.90836744 |
| 106 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.90807357 |
| 107 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.90696451 |
| 108 | protein-cofactor linkage (GO:0018065) | 2.89779445 |
| 109 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.89556917 |
| 110 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.89556917 |
| 111 | IMP metabolic process (GO:0046040) | 2.88693274 |
| 112 | mRNA catabolic process (GO:0006402) | 2.88160289 |
| 113 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.87279789 |
| 114 | macromolecular complex disassembly (GO:0032984) | 2.86417229 |
| 115 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.86340926 |
| 116 | meiotic chromosome segregation (GO:0045132) | 2.85467866 |
| 117 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.85459168 |
| 118 | telomere maintenance (GO:0000723) | 2.85388051 |
| 119 | telomere organization (GO:0032200) | 2.84668825 |
| 120 | regulation of spindle checkpoint (GO:0090231) | 2.83685337 |
| 121 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.82738525 |
| 122 | viral mRNA export from host cell nucleus (GO:0046784) | 2.81372089 |
| 123 | RNA catabolic process (GO:0006401) | 2.81136039 |
| 124 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.81100386 |
| 125 | rRNA modification (GO:0000154) | 2.81001449 |
| 126 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.80859613 |
| 127 | RNA-dependent DNA replication (GO:0006278) | 2.80314637 |
| 128 | 7-methylguanosine RNA capping (GO:0009452) | 2.79529113 |
| 129 | RNA capping (GO:0036260) | 2.79529113 |
| 130 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.79062220 |
| 131 | cell cycle G1/S phase transition (GO:0044843) | 2.79062220 |
| 132 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.78702453 |
| 133 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.78702453 |
| 134 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.78044352 |
| 135 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.77855027 |
| 136 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.77349760 |
| 137 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.77349760 |
| 138 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.77349760 |
| 139 | metaphase plate congression (GO:0051310) | 2.76693271 |
| 140 | establishment of integrated proviral latency (GO:0075713) | 2.76016536 |
| 141 | histone mRNA metabolic process (GO:0008334) | 2.74665468 |
| 142 | membrane disassembly (GO:0030397) | 2.73708627 |
| 143 | nuclear envelope disassembly (GO:0051081) | 2.73708627 |
| 144 | 7-methylguanosine mRNA capping (GO:0006370) | 2.72924874 |
| 145 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.71150729 |
| 146 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.70470614 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.01923442 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.30722040 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.54187850 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.42331411 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.29238516 |
| 6 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.20800754 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.10145415 |
| 8 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.92900519 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.89407045 |
| 10 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.81107965 |
| 11 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.78061468 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.75553573 |
| 13 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.64843138 |
| 14 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.61227218 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.57580493 |
| 16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.56681946 |
| 17 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.52735522 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.40109932 |
| 19 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.34949383 |
| 20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.27609329 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.25978055 |
| 22 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.25477049 |
| 23 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.25374965 |
| 24 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.21157190 |
| 25 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.20789829 |
| 26 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.19773653 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.08810265 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.04081457 |
| 29 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.02308277 |
| 30 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.01669237 |
| 31 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.00255073 |
| 32 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.99787509 |
| 33 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.99589082 |
| 34 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.96429636 |
| 35 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.92439766 |
| 36 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.89830237 |
| 37 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.88952019 |
| 38 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.88180470 |
| 39 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.87862266 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.87084708 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.85374154 |
| 42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.80810639 |
| 43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.79065356 |
| 44 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.75323193 |
| 45 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.74349523 |
| 46 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.72350513 |
| 47 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.71432624 |
| 48 | FUS_26573619_Chip-Seq_HEK293_Human | 1.70660633 |
| 49 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.68935132 |
| 50 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.68176409 |
| 51 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.65697655 |
| 52 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.64219578 |
| 53 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61537055 |
| 54 | EWS_26573619_Chip-Seq_HEK293_Human | 1.61092140 |
| 55 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.60490649 |
| 56 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.58926673 |
| 57 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.56423580 |
| 58 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.52614810 |
| 59 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.51183533 |
| 60 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.49941449 |
| 61 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.49499732 |
| 62 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.49006409 |
| 63 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.46874349 |
| 64 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.44270770 |
| 65 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.42980150 |
| 66 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.42874436 |
| 67 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.42757096 |
| 68 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.42096151 |
| 69 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.39435692 |
| 70 | MYC_22102868_ChIP-Seq_BL_Human | 1.39359071 |
| 71 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.34796684 |
| 72 | VDR_22108803_ChIP-Seq_LS180_Human | 1.30838611 |
| 73 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.30609447 |
| 74 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.27087955 |
| 75 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.25095047 |
| 76 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.24468391 |
| 77 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.20723276 |
| 78 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.19574896 |
| 79 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.14877421 |
| 80 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13726749 |
| 81 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.12875075 |
| 82 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.11801413 |
| 83 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.10493758 |
| 84 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.10392754 |
| 85 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.08273605 |
| 86 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.05891295 |
| 87 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.04431558 |
| 88 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.03560538 |
| 89 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02761295 |
| 90 | * STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.02434046 |
| 91 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.01789844 |
| 92 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.01304467 |
| 93 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00438216 |
| 94 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.99547400 |
| 95 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.99525248 |
| 96 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98881057 |
| 97 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.97821953 |
| 98 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.97433577 |
| 99 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.96659385 |
| 100 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.94808114 |
| 101 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.94459890 |
| 102 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.94087822 |
| 103 | MYB_26560356_Chip-Seq_TH1_Human | 0.93984267 |
| 104 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.93313078 |
| 105 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.93075752 |
| 106 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.92925909 |
| 107 | MYB_26560356_Chip-Seq_TH2_Human | 0.92188325 |
| 108 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.91833034 |
| 109 | * SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.90101855 |
| 110 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.89928002 |
| 111 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.89279624 |
| 112 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.86375970 |
| 113 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.85364396 |
| 114 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.83290739 |
| 115 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83227218 |
| 116 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.82923993 |
| 117 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.82872557 |
| 118 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.81822658 |
| 119 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.81007121 |
| 120 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.80153520 |
| 121 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.79068505 |
| 122 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.78673435 |
| 123 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.78647267 |
| 124 | * SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.78631682 |
| 125 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.77852976 |
| 126 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.77487994 |
| 127 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.77381489 |
| 128 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.77139365 |
| 129 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.76855278 |
| 130 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.75347313 |
| 131 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.72384409 |
| 132 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.72000404 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.68099507 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.93228984 |
| 3 | MP0008057_abnormal_DNA_replication | 3.91677769 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.74685287 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.50917181 |
| 6 | MP0003077_abnormal_cell_cycle | 3.36201770 |
| 7 | MP0002396_abnormal_hematopoietic_system | 3.12981152 |
| 8 | MP0008058_abnormal_DNA_repair | 2.95232277 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.86772147 |
| 10 | MP0003763_abnormal_thymus_physiology | 2.49731627 |
| 11 | MP0001835_abnormal_antigen_presentation | 2.46930923 |
| 12 | MP0001529_abnormal_vocalization | 2.45410993 |
| 13 | MP0005671_abnormal_response_to | 2.25974297 |
| 14 | MP0000490_abnormal_crypts_of | 2.23653650 |
| 15 | MP0008932_abnormal_embryonic_tissue | 2.09472239 |
| 16 | MP0009333_abnormal_splenocyte_physiolog | 1.93099998 |
| 17 | MP0009379_abnormal_foot_pigmentation | 1.90193436 |
| 18 | MP0003786_premature_aging | 1.83582070 |
| 19 | MP0009785_altered_susceptibility_to | 1.82697654 |
| 20 | MP0010352_gastrointestinal_tract_polyps | 1.82202032 |
| 21 | MP0006035_abnormal_mitochondrial_morpho | 1.80976524 |
| 22 | MP0002398_abnormal_bone_marrow | 1.80276953 |
| 23 | MP0005397_hematopoietic_system_phenotyp | 1.78119018 |
| 24 | MP0001545_abnormal_hematopoietic_system | 1.78119018 |
| 25 | MP0004808_abnormal_hematopoietic_stem | 1.77411181 |
| 26 | MP0000372_irregular_coat_pigmentation | 1.70581746 |
| 27 | MP0001853_heart_inflammation | 1.69055119 |
| 28 | MP0005075_abnormal_melanosome_morpholog | 1.68109550 |
| 29 | MP0006072_abnormal_retinal_apoptosis | 1.66678881 |
| 30 | MP0005253_abnormal_eye_physiology | 1.62355440 |
| 31 | MP0001800_abnormal_humoral_immune | 1.58388197 |
| 32 | MP0000685_abnormal_immune_system | 1.57889938 |
| 33 | MP0000350_abnormal_cell_proliferation | 1.57212720 |
| 34 | MP0002722_abnormal_immune_system | 1.56639492 |
| 35 | MP0000689_abnormal_spleen_morphology | 1.54383208 |
| 36 | MP0005174_abnormal_tail_pigmentation | 1.54184559 |
| 37 | MP0001727_abnormal_embryo_implantation | 1.52959940 |
| 38 | MP0002160_abnormal_reproductive_system | 1.50938596 |
| 39 | MP0000703_abnormal_thymus_morphology | 1.50790465 |
| 40 | MP0002019_abnormal_tumor_incidence | 1.49982506 |
| 41 | MP0002420_abnormal_adaptive_immunity | 1.49856256 |
| 42 | MP0003724_increased_susceptibility_to | 1.49153685 |
| 43 | MP0006292_abnormal_olfactory_placode | 1.48991140 |
| 44 | MP0001819_abnormal_immune_cell | 1.48797761 |
| 45 | MP0003890_abnormal_embryonic-extraembry | 1.48333035 |
| 46 | MP0001730_embryonic_growth_arrest | 1.48292108 |
| 47 | MP0002452_abnormal_antigen_presenting | 1.48186605 |
| 48 | MP0001851_eye_inflammation | 1.46414732 |
| 49 | MP0002723_abnormal_immune_serum | 1.46241539 |
| 50 | MP0000716_abnormal_immune_system | 1.45291311 |
| 51 | MP0003436_decreased_susceptibility_to | 1.45191407 |
| 52 | MP0005000_abnormal_immune_tolerance | 1.44581376 |
| 53 | MP0005025_abnormal_response_to | 1.43374637 |
| 54 | MP0002429_abnormal_blood_cell | 1.42983297 |
| 55 | MP0003123_paternal_imprinting | 1.42548917 |
| 56 | MP0003186_abnormal_redox_activity | 1.40948326 |
| 57 | MP0000313_abnormal_cell_death | 1.40398432 |
| 58 | MP0008877_abnormal_DNA_methylation | 1.39681564 |
| 59 | MP0002006_tumorigenesis | 1.36149781 |
| 60 | MP0002405_respiratory_system_inflammati | 1.32549181 |
| 61 | MP0002163_abnormal_gland_morphology | 1.31944333 |
| 62 | MP0003646_muscle_fatigue | 1.30096248 |
| 63 | MP0002166_altered_tumor_susceptibility | 1.29902142 |
| 64 | MP0010307_abnormal_tumor_latency | 1.29811987 |
| 65 | MP0006054_spinal_hemorrhage | 1.29601015 |
| 66 | MP0003195_calcinosis | 1.29132347 |
| 67 | MP0002277_abnormal_respiratory_mucosa | 1.29124365 |
| 68 | MP0002095_abnormal_skin_pigmentation | 1.26916919 |
| 69 | MP0001929_abnormal_gametogenesis | 1.25969025 |
| 70 | MP0010386_abnormal_urinary_bladder | 1.25779799 |
| 71 | MP0002148_abnormal_hypersensitivity_rea | 1.24984434 |
| 72 | MP0003806_abnormal_nucleotide_metabolis | 1.23610107 |
| 73 | MP0004147_increased_porphyrin_level | 1.23332379 |
| 74 | MP0009697_abnormal_copulation | 1.23074619 |
| 75 | MP0005395_other_phenotype | 1.22793075 |
| 76 | MP0003718_maternal_effect | 1.22031468 |
| 77 | MP0003567_abnormal_fetal_cardiomyocyte | 1.21513646 |
| 78 | MP0003937_abnormal_limbs/digits/tail_de | 1.21303593 |
| 79 | MP0005197_abnormal_uvea_morphology | 1.20460445 |
| 80 | MP0001873_stomach_inflammation | 1.19499905 |
| 81 | MP0005408_hypopigmentation | 1.18295133 |
| 82 | MP0010155_abnormal_intestine_physiology | 1.17237182 |
| 83 | MP0008995_early_reproductive_senescence | 1.16755285 |
| 84 | MP0002132_abnormal_respiratory_system | 1.16511940 |
| 85 | MP0002419_abnormal_innate_immunity | 1.16048468 |
| 86 | MP0000858_altered_metastatic_potential | 1.15367442 |
| 87 | MP0002933_joint_inflammation | 1.11914801 |
| 88 | MP0000653_abnormal_sex_gland | 1.07995489 |
| 89 | MP0008789_abnormal_olfactory_epithelium | 1.07861086 |
| 90 | MP0005379_endocrine/exocrine_gland_phen | 1.06472458 |
| 91 | MP0002080_prenatal_lethality | 1.05550728 |
| 92 | MP0001697_abnormal_embryo_size | 1.04761923 |
| 93 | MP0005380_embryogenesis_phenotype | 1.03693390 |
| 94 | MP0001672_abnormal_embryogenesis/_devel | 1.03693390 |
| 95 | MP0001191_abnormal_skin_condition | 1.03199375 |
| 96 | MP0003136_yellow_coat_color | 1.02656865 |
| 97 | MP0004142_abnormal_muscle_tone | 1.02139714 |
| 98 | MP0005389_reproductive_system_phenotype | 1.00584509 |
| 99 | MP0005464_abnormal_platelet_physiology | 0.97481983 |
| 100 | MP0005391_vision/eye_phenotype | 0.95348002 |
| 101 | MP0002837_dystrophic_cardiac_calcinosis | 0.94990585 |
| 102 | MP0001790_abnormal_immune_system | 0.94640160 |
| 103 | MP0005387_immune_system_phenotype | 0.94640160 |
| 104 | MP0000647_abnormal_sebaceous_gland | 0.94070934 |
| 105 | MP0005084_abnormal_gallbladder_morpholo | 0.93210632 |
| 106 | MP0003984_embryonic_growth_retardation | 0.92849387 |
| 107 | MP0001845_abnormal_inflammatory_respons | 0.91710251 |
| 108 | MP0002088_abnormal_embryonic_growth/wei | 0.89341238 |
| 109 | MP0001905_abnormal_dopamine_level | 0.89235268 |
| 110 | MP0003011_delayed_dark_adaptation | 0.88701667 |
| 111 | MP0000465_gastrointestinal_hemorrhage | 0.87462049 |
| 112 | MP0002086_abnormal_extraembryonic_tissu | 0.85188002 |
| 113 | MP0003941_abnormal_skin_development | 0.84390896 |
| 114 | MP0001188_hyperpigmentation | 0.83704874 |
| 115 | MP0008875_abnormal_xenobiotic_pharmacok | 0.83082893 |
| 116 | MP0002009_preneoplasia | 0.81408013 |
| 117 | MP0008873_increased_physiological_sensi | 0.81316857 |
| 118 | MP0000015_abnormal_ear_pigmentation | 0.80714138 |
| 119 | MP0003315_abnormal_perineum_morphology | 0.80254739 |
| 120 | MP0002210_abnormal_sex_determination | 0.79799198 |
| 121 | MP0001324_abnormal_eye_pigmentation | 0.78996873 |
| 122 | MP0000631_abnormal_neuroendocrine_gland | 0.78755321 |
| 123 | MP0002102_abnormal_ear_morphology | 0.78444632 |
| 124 | MP0000358_abnormal_cell_content/ | 0.77331087 |
| 125 | MP0001119_abnormal_female_reproductive | 0.76424554 |
| 126 | MP0001293_anophthalmia | 0.75149308 |
| 127 | MP0002085_abnormal_embryonic_tissue | 0.74721275 |
| 128 | MP0005595_abnormal_vascular_smooth | 0.72918460 |
| 129 | MP0003943_abnormal_hepatobiliary_system | 0.72429577 |
| 130 | MP0002877_abnormal_melanocyte_morpholog | 0.72288849 |
| 131 | MP0002938_white_spotting | 0.71815837 |
| 132 | MP0008469_abnormal_protein_level | 0.70795259 |
| 133 | MP0002234_abnormal_pharynx_morphology | 0.70657598 |
| 134 | MP0001145_abnormal_male_reproductive | 0.70489863 |
| 135 | MP0003866_abnormal_defecation | 0.70251908 |
| 136 | MP0001764_abnormal_homeostasis | 0.69740618 |
| 137 | MP0006082_CNS_inflammation | 0.69462996 |
| 138 | MP0001286_abnormal_eye_development | 0.69022108 |
| 139 | MP0002075_abnormal_coat/hair_pigmentati | 0.68731096 |
| 140 | MP0000477_abnormal_intestine_morphology | 0.67258167 |
| 141 | MP0003448_altered_tumor_morphology | 0.67231924 |
| 142 | MP0003699_abnormal_female_reproductive | 0.67090654 |
| 143 | MP0005187_abnormal_penis_morphology | 0.66574876 |
| 144 | MP0006036_abnormal_mitochondrial_physio | 0.66563824 |
| 145 | MP0003828_pulmonary_edema | 0.66338606 |
| 146 | MP0002697_abnormal_eye_size | 0.66076864 |
| 147 | MP0002084_abnormal_developmental_patter | 0.64253620 |
| 148 | MP0003755_abnormal_palate_morphology | 0.64026857 |
| 149 | MP0009250_abnormal_appendicular_skeleto | 0.62802971 |
| 150 | MP0004197_abnormal_fetal_growth/weight/ | 0.62351402 |
| 151 | MP0001881_abnormal_mammary_gland | 0.62296470 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 4.97932739 |
| 2 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.92217508 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 4.87614357 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 4.56417104 |
| 5 | Birth length less than 3rd percentile (HP:0003561) | 4.08450282 |
| 6 | Acute encephalopathy (HP:0006846) | 4.00833283 |
| 7 | Aplastic anemia (HP:0001915) | 3.98255772 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.96521979 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.88401319 |
| 10 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.75432010 |
| 11 | Pallor (HP:0000980) | 3.60988980 |
| 12 | Mitochondrial inheritance (HP:0001427) | 3.60032585 |
| 13 | Periodontitis (HP:0000704) | 3.55740612 |
| 14 | Increased CSF lactate (HP:0002490) | 3.54267988 |
| 15 | Oral leukoplakia (HP:0002745) | 3.36979329 |
| 16 | Macrocytic anemia (HP:0001972) | 3.26008435 |
| 17 | Chromsome breakage (HP:0040012) | 3.14598143 |
| 18 | Sparse scalp hair (HP:0002209) | 3.14300270 |
| 19 | Lipid accumulation in hepatocytes (HP:0006561) | 3.14257926 |
| 20 | Colon cancer (HP:0003003) | 3.11941660 |
| 21 | Abnormality of chromosome stability (HP:0003220) | 3.09684448 |
| 22 | Thrombocytosis (HP:0001894) | 3.07708930 |
| 23 | Cerebral edema (HP:0002181) | 3.07378261 |
| 24 | 11 pairs of ribs (HP:0000878) | 3.06750502 |
| 25 | Deep philtrum (HP:0002002) | 3.05056147 |
| 26 | IgM deficiency (HP:0002850) | 3.00530636 |
| 27 | Type I transferrin isoform profile (HP:0003642) | 2.94978924 |
| 28 | Agnosia (HP:0010524) | 2.88656731 |
| 29 | Hepatocellular necrosis (HP:0001404) | 2.88468727 |
| 30 | Nasal speech (HP:0001611) | 2.81206749 |
| 31 | Reduced antithrombin III activity (HP:0001976) | 2.80018631 |
| 32 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.77404360 |
| 33 | Chronic bronchitis (HP:0004469) | 2.74897389 |
| 34 | Pancytopenia (HP:0001876) | 2.67105831 |
| 35 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.66862373 |
| 36 | Rough bone trabeculation (HP:0100670) | 2.63115837 |
| 37 | Petechiae (HP:0000967) | 2.60347819 |
| 38 | Selective tooth agenesis (HP:0001592) | 2.57697458 |
| 39 | Abnormality of the preputium (HP:0100587) | 2.56970391 |
| 40 | Myelodysplasia (HP:0002863) | 2.55139568 |
| 41 | Maternal diabetes (HP:0009800) | 2.55040300 |
| 42 | Hepatic necrosis (HP:0002605) | 2.54058111 |
| 43 | Premature graying of hair (HP:0002216) | 2.52231018 |
| 44 | Renal Fanconi syndrome (HP:0001994) | 2.50834379 |
| 45 | Lymphoma (HP:0002665) | 2.50538427 |
| 46 | Abnormality of the anterior horn cell (HP:0006802) | 2.48379892 |
| 47 | Degeneration of anterior horn cells (HP:0002398) | 2.48379892 |
| 48 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.47753947 |
| 49 | Carpal bone hypoplasia (HP:0001498) | 2.46190776 |
| 50 | Type 2 muscle fiber atrophy (HP:0003554) | 2.44165985 |
| 51 | Muscle fiber atrophy (HP:0100295) | 2.42720987 |
| 52 | Absent thumb (HP:0009777) | 2.42504287 |
| 53 | Abnormality of DNA repair (HP:0003254) | 2.40485888 |
| 54 | IgG deficiency (HP:0004315) | 2.39894700 |
| 55 | Esophageal atresia (HP:0002032) | 2.38590319 |
| 56 | Entropion (HP:0000621) | 2.37387629 |
| 57 | Microvesicular hepatic steatosis (HP:0001414) | 2.35003444 |
| 58 | Microretrognathia (HP:0000308) | 2.32961604 |
| 59 | Small intestinal stenosis (HP:0012848) | 2.30579562 |
| 60 | Duodenal stenosis (HP:0100867) | 2.30579562 |
| 61 | Poor head control (HP:0002421) | 2.30040191 |
| 62 | Abnormality of the labia minora (HP:0012880) | 2.28646341 |
| 63 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.28181239 |
| 64 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.28181239 |
| 65 | Optic disc pallor (HP:0000543) | 2.27308634 |
| 66 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.26907639 |
| 67 | Bone marrow hypocellularity (HP:0005528) | 2.25658858 |
| 68 | Meckel diverticulum (HP:0002245) | 2.25636931 |
| 69 | Abnormality of T cells (HP:0002843) | 2.25205527 |
| 70 | Autoimmune hemolytic anemia (HP:0001890) | 2.24812853 |
| 71 | Recurrent abscess formation (HP:0002722) | 2.24129612 |
| 72 | Breast hypoplasia (HP:0003187) | 2.22571424 |
| 73 | Amaurosis fugax (HP:0100576) | 2.22060799 |
| 74 | 3-Methylglutaconic aciduria (HP:0003535) | 2.21501386 |
| 75 | Poikiloderma (HP:0001029) | 2.21257774 |
| 76 | T lymphocytopenia (HP:0005403) | 2.15523822 |
| 77 | Cellular immunodeficiency (HP:0005374) | 2.14844558 |
| 78 | Pulmonary fibrosis (HP:0002206) | 2.14747080 |
| 79 | Abnormality of the ileum (HP:0001549) | 2.14683473 |
| 80 | Abnormality of methionine metabolism (HP:0010901) | 2.13219933 |
| 81 | Abnormality of midbrain morphology (HP:0002418) | 2.13181642 |
| 82 | Molar tooth sign on MRI (HP:0002419) | 2.13181642 |
| 83 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.12159712 |
| 84 | Cerebellar dysplasia (HP:0007033) | 2.11753484 |
| 85 | Leukodystrophy (HP:0002415) | 2.11024857 |
| 86 | Recurrent bronchitis (HP:0002837) | 2.09709050 |
| 87 | Abnormality of T cell physiology (HP:0011840) | 2.08399782 |
| 88 | Severe combined immunodeficiency (HP:0004430) | 2.07460265 |
| 89 | Abnormal spermatogenesis (HP:0008669) | 2.06987131 |
| 90 | Abnormality of the intervertebral disk (HP:0005108) | 2.06563115 |
| 91 | Abnormality of the renal collecting system (HP:0004742) | 2.05829287 |
| 92 | Lactic acidosis (HP:0003128) | 2.05473348 |
| 93 | Cortical visual impairment (HP:0100704) | 2.04332099 |
| 94 | Septo-optic dysplasia (HP:0100842) | 2.04188830 |
| 95 | Medulloblastoma (HP:0002885) | 2.04157592 |
| 96 | Increased hepatocellular lipid droplets (HP:0006565) | 2.03291234 |
| 97 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.02810732 |
| 98 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.02810732 |
| 99 | Abnormal protein glycosylation (HP:0012346) | 2.02810732 |
| 100 | Abnormal glycosylation (HP:0012345) | 2.02810732 |
| 101 | Abnormal trabecular bone morphology (HP:0100671) | 2.02063991 |
| 102 | Leukocytosis (HP:0001974) | 2.01064838 |
| 103 | Abnormality of T cell number (HP:0011839) | 2.01059006 |
| 104 | Abnormality of the duodenum (HP:0002246) | 2.00808010 |
| 105 | Combined immunodeficiency (HP:0005387) | 1.99893345 |
| 106 | Respiratory difficulties (HP:0002880) | 1.99714523 |
| 107 | Acute myeloid leukemia (HP:0004808) | 1.99502490 |
| 108 | Abnormality of the pons (HP:0007361) | 1.98945890 |
| 109 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.98881380 |
| 110 | Cleft eyelid (HP:0000625) | 1.98607085 |
| 111 | Respiratory failure (HP:0002878) | 1.98371206 |
| 112 | Cerebral hypomyelination (HP:0006808) | 1.97949294 |
| 113 | Increased serum pyruvate (HP:0003542) | 1.96616095 |
| 114 | Gastrointestinal atresia (HP:0002589) | 1.96469379 |
| 115 | Sparse eyelashes (HP:0000653) | 1.96379260 |
| 116 | Increased serum lactate (HP:0002151) | 1.96247409 |
| 117 | Secondary amenorrhea (HP:0000869) | 1.95356362 |
| 118 | Hypoplasia of the fovea (HP:0007750) | 1.95128873 |
| 119 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.95128873 |
| 120 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.94565237 |
| 121 | Impulsivity (HP:0100710) | 1.92125718 |
| 122 | Volvulus (HP:0002580) | 1.91641178 |
| 123 | Congenital, generalized hypertrichosis (HP:0004540) | 1.91285904 |
| 124 | Pancreatic cysts (HP:0001737) | 1.91155856 |
| 125 | Increased intramyocellular lipid droplets (HP:0012240) | 1.91059250 |
| 126 | Abnormality of B cell number (HP:0010975) | 1.90784841 |
| 127 | B lymphocytopenia (HP:0010976) | 1.90784841 |
| 128 | Supernumerary spleens (HP:0009799) | 1.89538126 |
| 129 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.89420846 |
| 130 | Exertional dyspnea (HP:0002875) | 1.88573599 |
| 131 | Exercise intolerance (HP:0003546) | 1.87081081 |
| 132 | Basal cell carcinoma (HP:0002671) | 1.87077040 |
| 133 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.84612945 |
| 134 | Abnormality of alanine metabolism (HP:0010916) | 1.84612945 |
| 135 | Hyperalaninemia (HP:0003348) | 1.84612945 |
| 136 | Patellar aplasia (HP:0006443) | 1.84329342 |
| 137 | Abnormal lung lobation (HP:0002101) | 1.84047750 |
| 138 | Duplicated collecting system (HP:0000081) | 1.83978379 |
| 139 | Sloping forehead (HP:0000340) | 1.83893105 |
| 140 | Chronic otitis media (HP:0000389) | 1.82646504 |
| 141 | Premature ovarian failure (HP:0008209) | 1.82385699 |
| 142 | Neoplasm of the pancreas (HP:0002894) | 1.81782219 |
| 143 | Recurrent viral infections (HP:0004429) | 1.81593195 |
| 144 | Irregular epiphyses (HP:0010582) | 1.81363243 |
| 145 | Recurrent bacterial skin infections (HP:0005406) | 1.81219230 |
| 146 | Stenosis of the external auditory canal (HP:0000402) | 1.80377237 |
| 147 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.80369854 |
| 148 | Recurrent fungal infections (HP:0002841) | 1.80263433 |
| 149 | Triphalangeal thumb (HP:0001199) | 1.80257305 |
| 150 | Hypoplasia of the uterus (HP:0000013) | 1.80254535 |
| 151 | Squamous cell carcinoma (HP:0002860) | 1.79650279 |
| 152 | Median cleft lip (HP:0000161) | 1.79608744 |
| 153 | Lethargy (HP:0001254) | 1.79526331 |
| 154 | Hyperglycinemia (HP:0002154) | 1.79367650 |
| 155 | Acute lymphatic leukemia (HP:0006721) | 1.79239913 |
| 156 | Rhabdomyosarcoma (HP:0002859) | 1.78760039 |
| 157 | Abnormality of the septum pellucidum (HP:0007375) | 1.77344097 |
| 158 | Abnormality of macular pigmentation (HP:0008002) | 1.74091522 |
| 159 | Abnormality of the fovea (HP:0000493) | 1.73972238 |
| 160 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.73542834 |
| 161 | Autoimmune thrombocytopenia (HP:0001973) | 1.71721480 |
| 162 | Abnormality of renal resorption (HP:0011038) | 1.71212725 |
| 163 | Absent septum pellucidum (HP:0001331) | 1.71015966 |
| 164 | Pancreatic fibrosis (HP:0100732) | 1.70651624 |
| 165 | Clubbing of toes (HP:0100760) | 1.67778616 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | WEE1 | 3.97348720 |
| 2 | EIF2AK1 | 3.55754211 |
| 3 | BUB1 | 3.36124071 |
| 4 | STK16 | 3.28918895 |
| 5 | NME2 | 3.23066988 |
| 6 | EIF2AK3 | 2.68832572 |
| 7 | CDC7 | 2.56484611 |
| 8 | VRK2 | 2.39639217 |
| 9 | SRPK1 | 2.28179555 |
| 10 | VRK1 | 2.16907557 |
| 11 | PRKCH | 2.12963350 |
| 12 | ACVR1B | 2.12595371 |
| 13 | DYRK3 | 2.04929863 |
| 14 | PIM2 | 1.95782341 |
| 15 | BRSK2 | 1.88718963 |
| 16 | MAP4K2 | 1.87385696 |
| 17 | PNCK | 1.85920204 |
| 18 | PLK4 | 1.84188583 |
| 19 | MAP4K1 | 1.82003807 |
| 20 | MKNK1 | 1.81040985 |
| 21 | TSSK6 | 1.78894444 |
| 22 | NEK2 | 1.77493965 |
| 23 | TLK1 | 1.74208549 |
| 24 | NME1 | 1.71467532 |
| 25 | MKNK2 | 1.69269084 |
| 26 | KIT | 1.68694083 |
| 27 | NEK1 | 1.67778198 |
| 28 | TEC | 1.63939795 |
| 29 | TXK | 1.61986197 |
| 30 | RPS6KA4 | 1.58940388 |
| 31 | CDK7 | 1.49590830 |
| 32 | TRIM28 | 1.48519432 |
| 33 | TAF1 | 1.45225857 |
| 34 | ATR | 1.44002432 |
| 35 | FLT3 | 1.43286490 |
| 36 | PLK1 | 1.40563586 |
| 37 | KDR | 1.38062290 |
| 38 | AURKB | 1.37492361 |
| 39 | TTK | 1.35058248 |
| 40 | TNIK | 1.31605854 |
| 41 | EIF2AK2 | 1.30851781 |
| 42 | BMPR1B | 1.27566727 |
| 43 | IRAK4 | 1.24122666 |
| 44 | NLK | 1.23790632 |
| 45 | CDK8 | 1.22592788 |
| 46 | DAPK1 | 1.21992023 |
| 47 | MAP2K6 | 1.20090899 |
| 48 | PIM1 | 1.19010303 |
| 49 | RPS6KB2 | 1.13736121 |
| 50 | PBK | 1.09576187 |
| 51 | STK10 | 1.08987089 |
| 52 | TAOK3 | 1.08044981 |
| 53 | PASK | 1.07625013 |
| 54 | PLK3 | 1.07397179 |
| 55 | CDK4 | 1.07369711 |
| 56 | MST4 | 1.06500256 |
| 57 | ZAK | 1.01322149 |
| 58 | SCYL2 | 0.99990496 |
| 59 | TGFBR1 | 0.99990279 |
| 60 | MAP3K8 | 0.99885231 |
| 61 | WNK3 | 0.97609310 |
| 62 | TESK2 | 0.96730184 |
| 63 | ERBB3 | 0.95912241 |
| 64 | JAK3 | 0.93167972 |
| 65 | IRAK3 | 0.90605451 |
| 66 | NUAK1 | 0.90031874 |
| 67 | IKBKB | 0.89771383 |
| 68 | MAP3K14 | 0.89426917 |
| 69 | CHEK2 | 0.85397238 |
| 70 | ALK | 0.84762291 |
| 71 | FRK | 0.82663510 |
| 72 | STK4 | 0.82343217 |
| 73 | ZAP70 | 0.80891908 |
| 74 | TYK2 | 0.79207084 |
| 75 | TBK1 | 0.79084025 |
| 76 | CHEK1 | 0.78872943 |
| 77 | BTK | 0.78700604 |
| 78 | AURKA | 0.77177093 |
| 79 | MAP2K3 | 0.76170220 |
| 80 | INSRR | 0.74167256 |
| 81 | BLK | 0.74022682 |
| 82 | NEK9 | 0.71631908 |
| 83 | CSNK2A2 | 0.70891022 |
| 84 | BRSK1 | 0.70104971 |
| 85 | MAP3K11 | 0.69584441 |
| 86 | CSNK2A1 | 0.68078789 |
| 87 | CDK3 | 0.64686749 |
| 88 | CLK1 | 0.64480855 |
| 89 | ATM | 0.63893584 |
| 90 | TAOK2 | 0.62314533 |
| 91 | LYN | 0.61190761 |
| 92 | PAK4 | 0.60744917 |
| 93 | TIE1 | 0.60614870 |
| 94 | RPS6KA5 | 0.57942736 |
| 95 | LCK | 0.56374445 |
| 96 | MATK | 0.55856339 |
| 97 | CSF1R | 0.55793864 |
| 98 | MAP3K5 | 0.54808893 |
| 99 | YES1 | 0.52608940 |
| 100 | SYK | 0.52486626 |
| 101 | CCNB1 | 0.51186110 |
| 102 | FES | 0.51169777 |
| 103 | CDK2 | 0.50949991 |
| 104 | CSNK1E | 0.50729119 |
| 105 | GRK1 | 0.50066999 |
| 106 | IKBKE | 0.49460896 |
| 107 | ADRBK1 | 0.48964828 |
| 108 | RAF1 | 0.48950777 |
| 109 | MAPKAPK3 | 0.47722643 |
| 110 | ERBB4 | 0.47682490 |
| 111 | STK24 | 0.47448905 |
| 112 | CHUK | 0.46874179 |
| 113 | LRRK2 | 0.46281879 |
| 114 | EPHA2 | 0.46190583 |
| 115 | OXSR1 | 0.44440590 |
| 116 | CSNK1G1 | 0.44304224 |
| 117 | PDK2 | 0.43859048 |
| 118 | STK39 | 0.43771489 |
| 119 | MUSK | 0.43749231 |
| 120 | PLK2 | 0.43631695 |
| 121 | IRAK1 | 0.41944221 |
| 122 | MAP3K3 | 0.40856635 |
| 123 | ABL2 | 0.40681259 |
| 124 | MAP3K12 | 0.40215093 |
| 125 | MARK3 | 0.36572246 |
| 126 | STK3 | 0.34950292 |
| 127 | MAPKAPK5 | 0.32946446 |
| 128 | CDK6 | 0.32466071 |
| 129 | CDK1 | 0.32453017 |
| 130 | DYRK2 | 0.30904092 |
| 131 | ADRBK2 | 0.30173848 |
| 132 | MAPK15 | 0.29805752 |
| 133 | ILK | 0.28699428 |
| 134 | CSNK1G3 | 0.27547164 |
| 135 | FGFR1 | 0.27351836 |
| 136 | GSK3A | 0.26948311 |
| 137 | CDK9 | 0.25738601 |
| 138 | PRKCQ | 0.24018890 |
| 139 | WNK4 | 0.23558682 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.49362799 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.20226006 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.77725563 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.48825573 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 3.48698251 |
| 6 | * RNA polymerase_Homo sapiens_hsa03020 | 3.27420165 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.99930209 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.98619937 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.67460310 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.67119775 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.59230139 |
| 12 | * Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.52254746 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.30170056 |
| 14 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.22175674 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.14073981 |
| 16 | Cell cycle_Homo sapiens_hsa04110 | 2.13973269 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.13008972 |
| 18 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.07852457 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.02181880 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.96054112 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.88496405 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.77607330 |
| 23 | Protein export_Homo sapiens_hsa03060 | 1.63008703 |
| 24 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.48972966 |
| 25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.48080469 |
| 26 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.39180432 |
| 27 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.35564125 |
| 28 | * Purine metabolism_Homo sapiens_hsa00230 | 1.31881915 |
| 29 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.28613897 |
| 30 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.20892378 |
| 31 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.13674806 |
| 32 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.12238173 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.04765872 |
| 34 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.01424259 |
| 35 | Measles_Homo sapiens_hsa05162 | 1.01121189 |
| 36 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.98356572 |
| 37 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.97248731 |
| 38 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91464484 |
| 39 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.90929686 |
| 40 | Legionellosis_Homo sapiens_hsa05134 | 0.88756647 |
| 41 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.88699349 |
| 42 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.87714070 |
| 43 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.87493539 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.84121100 |
| 45 | Allograft rejection_Homo sapiens_hsa05330 | 0.83196230 |
| 46 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.82149220 |
| 47 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.79817258 |
| 48 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.79265661 |
| 49 | Thyroid cancer_Homo sapiens_hsa05216 | 0.77724113 |
| 50 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.70823996 |
| 51 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.70648101 |
| 52 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.69872249 |
| 53 | Leishmaniasis_Homo sapiens_hsa05140 | 0.69079548 |
| 54 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.68612748 |
| 55 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.68357089 |
| 56 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.67284118 |
| 57 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.61889467 |
| 58 | Apoptosis_Homo sapiens_hsa04210 | 0.61613070 |
| 59 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.60766903 |
| 60 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.58546698 |
| 61 | HTLV-I infection_Homo sapiens_hsa05166 | 0.57862691 |
| 62 | Shigellosis_Homo sapiens_hsa05131 | 0.57460782 |
| 63 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.56628327 |
| 64 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.55794214 |
| 65 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.55163608 |
| 66 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.55098311 |
| 67 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.54785930 |
| 68 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.53897006 |
| 69 | Asthma_Homo sapiens_hsa05310 | 0.53829910 |
| 70 | Influenza A_Homo sapiens_hsa05164 | 0.53717306 |
| 71 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.52917618 |
| 72 | Hepatitis B_Homo sapiens_hsa05161 | 0.52914352 |
| 73 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52621159 |
| 74 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.52353574 |
| 75 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.52208863 |
| 76 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.51867592 |
| 77 | Phototransduction_Homo sapiens_hsa04744 | 0.50837982 |
| 78 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.50365830 |
| 79 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.50123200 |
| 80 | Huntingtons disease_Homo sapiens_hsa05016 | 0.49759408 |
| 81 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.46594920 |
| 82 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.46274275 |
| 83 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.44605476 |
| 84 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.43784803 |
| 85 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.43227673 |
| 86 | Parkinsons disease_Homo sapiens_hsa05012 | 0.42854518 |
| 87 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.42031162 |
| 88 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.41618703 |
| 89 | Other glycan degradation_Homo sapiens_hsa00511 | 0.40660625 |
| 90 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.40326065 |
| 91 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.39799292 |
| 92 | Carbon metabolism_Homo sapiens_hsa01200 | 0.39725181 |
| 93 | Peroxisome_Homo sapiens_hsa04146 | 0.39052582 |
| 94 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.38682672 |
| 95 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.37211001 |
| 96 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.36845834 |
| 97 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.36834894 |
| 98 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.36662700 |
| 99 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.36353945 |
| 100 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.35666230 |
| 101 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.35343952 |
| 102 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.30702300 |
| 103 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.29935575 |
| 104 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.29905730 |
| 105 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29013559 |
| 106 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.27157991 |
| 107 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.26988687 |
| 108 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.26872458 |
| 109 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.26529795 |
| 110 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.26383740 |
| 111 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.24704339 |
| 112 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.24657400 |
| 113 | Malaria_Homo sapiens_hsa05144 | 0.24154056 |
| 114 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.23704176 |
| 115 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.23659069 |
| 116 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.23340819 |
| 117 | Alcoholism_Homo sapiens_hsa05034 | 0.22722548 |
| 118 | Pertussis_Homo sapiens_hsa05133 | 0.22427702 |
| 119 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.22217625 |
| 120 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.22083775 |
| 121 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.21839810 |
| 122 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.21555129 |
| 123 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.21537648 |
| 124 | Colorectal cancer_Homo sapiens_hsa05210 | 0.20533164 |
| 125 | Olfactory transduction_Homo sapiens_hsa04740 | 0.20446024 |
| 126 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.20214497 |
| 127 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.19040663 |
| 128 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.18742515 |
| 129 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.18164868 |
| 130 | Viral myocarditis_Homo sapiens_hsa05416 | 0.17924719 |
| 131 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.17644487 |
| 132 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.17352156 |
| 133 | Tuberculosis_Homo sapiens_hsa05152 | 0.16827952 |
| 134 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.15789576 |
| 135 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.15322274 |
| 136 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.15225345 |
| 137 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.14118283 |
| 138 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.12861400 |
| 139 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.12842410 |

