

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 7.28158864 |
| 2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.01794622 |
| 3 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.88613456 |
| 4 | negative regulation of cell killing (GO:0031342) | 6.88613456 |
| 5 | positive T cell selection (GO:0043368) | 6.61889568 |
| 6 | negative thymic T cell selection (GO:0045060) | 6.55047779 |
| 7 | cellular response to interleukin-15 (GO:0071350) | 6.41051066 |
| 8 | positive thymic T cell selection (GO:0045059) | 6.07111100 |
| 9 | * interferon-gamma production (GO:0032609) | 6.03455532 |
| 10 | regulation of gamma-delta T cell differentiation (GO:0045586) | 5.92586976 |
| 11 | response to interleukin-15 (GO:0070672) | 5.91004747 |
| 12 | T cell selection (GO:0045058) | 5.74518925 |
| 13 | regulation of gamma-delta T cell activation (GO:0046643) | 5.71730546 |
| 14 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 5.59517815 |
| 15 | thymic T cell selection (GO:0045061) | 5.47827160 |
| 16 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.44651849 |
| 17 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.35784123 |
| 18 | leukocyte aggregation (GO:0070486) | 5.12249100 |
| 19 | T cell migration (GO:0072678) | 5.04507960 |
| 20 | activated T cell proliferation (GO:0050798) | 4.90336905 |
| 21 | regulation of T cell tolerance induction (GO:0002664) | 4.63942993 |
| 22 | * T cell receptor signaling pathway (GO:0050852) | 4.63796189 |
| 23 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.39255966 |
| 24 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.20823531 |
| 25 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.20823531 |
| 26 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.19816729 |
| 27 | regulation of natural killer cell mediated immunity (GO:0002715) | 4.19816729 |
| 28 | T cell costimulation (GO:0031295) | 4.19091346 |
| 29 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.17229060 |
| 30 | T-helper cell differentiation (GO:0042093) | 4.17027194 |
| 31 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 4.17027194 |
| 32 | lymphocyte costimulation (GO:0031294) | 4.14031239 |
| 33 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.13791037 |
| 34 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.13617706 |
| 35 | positive regulation of granulocyte differentiation (GO:0030854) | 4.12903749 |
| 36 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.09907939 |
| 37 | tolerance induction (GO:0002507) | 4.02910625 |
| 38 | T cell differentiation involved in immune response (GO:0002292) | 4.02892258 |
| 39 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 4.02892258 |
| 40 | alpha-beta T cell activation involved in immune response (GO:0002287) | 4.02892258 |
| 41 | * alpha-beta T cell differentiation (GO:0046632) | 4.02114745 |
| 42 | positive regulation of isotype switching (GO:0045830) | 4.00909253 |
| 43 | positive regulation of interleukin-2 production (GO:0032743) | 4.00384042 |
| 44 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.98992457 |
| 45 | * alpha-beta T cell activation (GO:0046631) | 3.97837356 |
| 46 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.97578502 |
| 47 | * antigen receptor-mediated signaling pathway (GO:0050851) | 3.96660437 |
| 48 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.94352528 |
| 49 | negative regulation of T cell mediated immunity (GO:0002710) | 3.93365403 |
| 50 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.86675383 |
| 51 | * T cell differentiation (GO:0030217) | 3.84778863 |
| 52 | regulation of cell killing (GO:0031341) | 3.84107583 |
| 53 | mast cell activation (GO:0045576) | 3.82957068 |
| 54 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.78150985 |
| 55 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.78150985 |
| 56 | natural killer cell activation (GO:0030101) | 3.74202214 |
| 57 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.72905409 |
| 58 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.72172045 |
| 59 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.72170883 |
| 60 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.68643908 |
| 61 | positive regulation of DNA recombination (GO:0045911) | 3.67941915 |
| 62 | positive regulation of B cell mediated immunity (GO:0002714) | 3.66332365 |
| 63 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.66332365 |
| 64 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 3.63013781 |
| 65 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.62395182 |
| 66 | positive regulation of cell killing (GO:0031343) | 3.61392354 |
| 67 | positive regulation of tolerance induction (GO:0002645) | 3.58802106 |
| 68 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.58291397 |
| 69 | positive regulation of humoral immune response (GO:0002922) | 3.55305319 |
| 70 | cell wall macromolecule catabolic process (GO:0016998) | 3.53708777 |
| 71 | regulation of isotype switching (GO:0045191) | 3.48272654 |
| 72 | mast cell activation involved in immune response (GO:0002279) | 3.43092922 |
| 73 | mast cell degranulation (GO:0043303) | 3.43092922 |
| 74 | regulation of tolerance induction (GO:0002643) | 3.42242328 |
| 75 | NIK/NF-kappaB signaling (GO:0038061) | 3.40554718 |
| 76 | T cell activation involved in immune response (GO:0002286) | 3.38047553 |
| 77 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.35514894 |
| 78 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.34868883 |
| 79 | B cell receptor signaling pathway (GO:0050853) | 3.33688917 |
| 80 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 3.32467336 |
| 81 | V(D)J recombination (GO:0033151) | 3.32264393 |
| 82 | response to muramyl dipeptide (GO:0032495) | 3.30741279 |
| 83 | * T cell activation (GO:0042110) | 3.30604428 |
| 84 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.30362548 |
| 85 | cellular defense response (GO:0006968) | 3.29440327 |
| 86 | regulation of T cell mediated immunity (GO:0002709) | 3.27828061 |
| 87 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.27742785 |
| 88 | positive regulation of T cell differentiation in thymus (GO:0033089) | 3.23687497 |
| 89 | positive regulation of T cell mediated immunity (GO:0002711) | 3.22179938 |
| 90 | sequestering of actin monomers (GO:0042989) | 3.22077327 |
| 91 | leukocyte cell-cell adhesion (GO:0007159) | 3.20915011 |
| 92 | negative regulation of innate immune response (GO:0045824) | 3.19916343 |
| 93 | regulation of memory T cell differentiation (GO:0043380) | 3.19118141 |
| 94 | regulation of B cell mediated immunity (GO:0002712) | 3.18363128 |
| 95 | response to type I interferon (GO:0034340) | 3.15189660 |
| 96 | lymph node development (GO:0048535) | 3.12967794 |
| 97 | T cell homeostasis (GO:0043029) | 3.12706555 |
| 98 | positive regulation of defense response to virus by host (GO:0002230) | 3.11543970 |
| 99 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.11134918 |
| 100 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.10350457 |
| 101 | myeloid dendritic cell activation (GO:0001773) | 3.09436161 |
| 102 | regulation of interleukin-2 production (GO:0032663) | 3.08810170 |
| 103 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.07699418 |
| 104 | Peyers patch development (GO:0048541) | 3.07699418 |
| 105 | cellular response to type I interferon (GO:0071357) | 3.07682255 |
| 106 | type I interferon signaling pathway (GO:0060337) | 3.07682255 |
| 107 | regulation of regulatory T cell differentiation (GO:0045589) | 3.07634248 |
| 108 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.07125472 |
| 109 | cell wall macromolecule metabolic process (GO:0044036) | 3.04589726 |
| 110 | * regulation of response to interferon-gamma (GO:0060330) | 3.03618420 |
| 111 | negative regulation of adaptive immune response (GO:0002820) | 3.01622193 |
| 112 | regulation of lymphocyte mediated immunity (GO:0002706) | 3.01208843 |
| 113 | regulation of B cell differentiation (GO:0045577) | 3.00319594 |
| 114 | * positive regulation of interferon-gamma production (GO:0032729) | 2.99539640 |
| 115 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 2.99345947 |
| 116 | positive regulation of B cell differentiation (GO:0045579) | 2.98586841 |
| 117 | regulation of activation of Janus kinase activity (GO:0010533) | 2.98365229 |
| 118 | regulation of alpha-beta T cell activation (GO:0046634) | 2.97371939 |
| 119 | * regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.97213991 |
| 120 | positive regulation of T cell cytokine production (GO:0002726) | 2.96971306 |
| 121 | lymphocyte homeostasis (GO:0002260) | 2.95670862 |
| 122 | leukocyte degranulation (GO:0043299) | 2.94416432 |
| 123 | positive regulation of T-helper 1 type immune response (GO:0002827) | 2.94190223 |
| 124 | protein K11-linked deubiquitination (GO:0035871) | 2.89512837 |
| 125 | natural killer cell differentiation (GO:0001779) | 2.89500999 |
| 126 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.86600595 |
| 127 | positive regulation of alpha-beta T cell activation (GO:0046635) | 2.86574771 |
| 128 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.85885621 |
| 129 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.85885621 |
| 130 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.83315193 |
| 131 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.80967654 |
| 132 | T cell proliferation (GO:0042098) | 2.78284108 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.76486612 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.81232249 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.77970372 |
| 4 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 4.44184076 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.40752715 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.93082305 |
| 7 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.85117416 |
| 8 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.81511468 |
| 9 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.76954450 |
| 10 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.39850396 |
| 11 | * MYB_26560356_Chip-Seq_TH2_Human | 3.34084569 |
| 12 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.14630822 |
| 13 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.84055207 |
| 14 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.80965868 |
| 15 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.76432815 |
| 16 | MYB_26560356_Chip-Seq_TH1_Human | 2.67211359 |
| 17 | MAF_26560356_Chip-Seq_TH1_Human | 2.53179653 |
| 18 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.42937439 |
| 19 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.34245173 |
| 20 | MYC_22102868_ChIP-Seq_BL_Human | 2.33946673 |
| 21 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.33215347 |
| 22 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.29624513 |
| 23 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.28261176 |
| 24 | * UTX_26944678_Chip-Seq_JUKART_Human | 2.22050913 |
| 25 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.19172542 |
| 26 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.12914286 |
| 27 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.07526734 |
| 28 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.99215274 |
| 29 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.98283769 |
| 30 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.91403590 |
| 31 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.89598099 |
| 32 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.88885531 |
| 33 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.86775602 |
| 34 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.77089634 |
| 35 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.75219345 |
| 36 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.71819433 |
| 37 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66945150 |
| 38 | MAF_26560356_Chip-Seq_TH2_Human | 1.66033828 |
| 39 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.65795718 |
| 40 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.61597168 |
| 41 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.60215162 |
| 42 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.47239276 |
| 43 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.45233224 |
| 44 | GATA3_26560356_Chip-Seq_TH2_Human | 1.43532257 |
| 45 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.40422803 |
| 46 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.39793143 |
| 47 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.38585041 |
| 48 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.37967422 |
| 49 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.37825933 |
| 50 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.35635151 |
| 51 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.35453238 |
| 52 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29430844 |
| 53 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.27849904 |
| 54 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.23157368 |
| 55 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.21952485 |
| 56 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20865353 |
| 57 | SPI1_23127762_ChIP-Seq_K562_Human | 1.20670057 |
| 58 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15915856 |
| 59 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.14573012 |
| 60 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.14558138 |
| 61 | GATA3_26560356_Chip-Seq_TH1_Human | 1.12334732 |
| 62 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.11259809 |
| 63 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.11128619 |
| 64 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.10909554 |
| 65 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.09909726 |
| 66 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.09642373 |
| 67 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.09499851 |
| 68 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.08927604 |
| 69 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.07314185 |
| 70 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.05521341 |
| 71 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.04438130 |
| 72 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.03923950 |
| 73 | * CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.01519280 |
| 74 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.00963508 |
| 75 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.00003114 |
| 76 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.99617586 |
| 77 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.99435460 |
| 78 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98898148 |
| 79 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.97499616 |
| 80 | * CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.97225431 |
| 81 | * GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.96561081 |
| 82 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.95600475 |
| 83 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.93362519 |
| 84 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.93080776 |
| 85 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.93057894 |
| 86 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.91475882 |
| 87 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.88766521 |
| 88 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.87740449 |
| 89 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.87532853 |
| 90 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.87157471 |
| 91 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.86965777 |
| 92 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86451897 |
| 93 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.85349106 |
| 94 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.85238417 |
| 95 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84509848 |
| 96 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.84363282 |
| 97 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84195753 |
| 98 | P300_27268052_Chip-Seq_Bcells_Human | 0.81603324 |
| 99 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.81559861 |
| 100 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.81285261 |
| 101 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.80493486 |
| 102 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.79163907 |
| 103 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.78019772 |
| 104 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.77866224 |
| 105 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.77736301 |
| 106 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.75333929 |
| 107 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.75295817 |
| 108 | VDR_22108803_ChIP-Seq_LS180_Human | 0.74945814 |
| 109 | * BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.74598197 |
| 110 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.74321726 |
| 111 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.73806808 |
| 112 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.73027721 |
| 113 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.72740325 |
| 114 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.72727463 |
| 115 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.71756079 |
| 116 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.69904819 |
| 117 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.69119517 |
| 118 | * PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.68125285 |
| 119 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.65769481 |
| 120 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.63688882 |
| 121 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.63553016 |
| 122 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.63004498 |
| 123 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.62948568 |
| 124 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.62846043 |
| 125 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.62005789 |
| 126 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.60709437 |
| 127 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.60488926 |
| 128 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.59668786 |
| 129 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.58746325 |
| 130 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.57830082 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 5.15195979 |
| 2 | MP0005671_abnormal_response_to | 5.01652047 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.66560305 |
| 4 | MP0009785_altered_susceptibility_to | 3.40550815 |
| 5 | MP0000685_abnormal_immune_system | 3.23689695 |
| 6 | MP0001800_abnormal_humoral_immune | 3.16974516 |
| 7 | MP0006082_CNS_inflammation | 3.16015851 |
| 8 | MP0001790_abnormal_immune_system | 3.08934531 |
| 9 | MP0005387_immune_system_phenotype | 3.08934531 |
| 10 | MP0005000_abnormal_immune_tolerance | 3.05477306 |
| 11 | MP0002420_abnormal_adaptive_immunity | 2.88366419 |
| 12 | * MP0002723_abnormal_immune_serum | 2.86654762 |
| 13 | MP0001819_abnormal_immune_cell | 2.86327190 |
| 14 | MP0002166_altered_tumor_susceptibility | 2.79674949 |
| 15 | MP0003724_increased_susceptibility_to | 2.77039154 |
| 16 | MP0002398_abnormal_bone_marrow | 2.68736140 |
| 17 | MP0002006_tumorigenesis | 2.65864254 |
| 18 | MP0002452_abnormal_antigen_presenting | 2.64726409 |
| 19 | MP0002405_respiratory_system_inflammati | 2.63262167 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 2.62625012 |
| 21 | MP0000703_abnormal_thymus_morphology | 2.62597650 |
| 22 | * MP0005025_abnormal_response_to | 2.58896682 |
| 23 | MP0002148_abnormal_hypersensitivity_rea | 2.40744208 |
| 24 | MP0000716_abnormal_immune_system | 2.40572272 |
| 25 | MP0010155_abnormal_intestine_physiology | 2.40215231 |
| 26 | MP0002722_abnormal_immune_system | 2.21683636 |
| 27 | MP0003436_decreased_susceptibility_to | 2.16866740 |
| 28 | MP0004947_skin_inflammation | 2.16260081 |
| 29 | MP0002419_abnormal_innate_immunity | 2.15750796 |
| 30 | MP0001873_stomach_inflammation | 2.10823568 |
| 31 | MP0000689_abnormal_spleen_morphology | 2.08348262 |
| 32 | MP0002132_abnormal_respiratory_system | 1.96234255 |
| 33 | MP0002429_abnormal_blood_cell | 1.91538473 |
| 34 | MP0003866_abnormal_defecation | 1.83892560 |
| 35 | MP0001845_abnormal_inflammatory_respons | 1.83266422 |
| 36 | MP0000858_altered_metastatic_potential | 1.80346548 |
| 37 | MP0002396_abnormal_hematopoietic_system | 1.79330270 |
| 38 | MP0002933_joint_inflammation | 1.79096841 |
| 39 | MP0004381_abnormal_hair_follicle | 1.76981838 |
| 40 | MP0004510_myositis | 1.75806676 |
| 41 | MP0005464_abnormal_platelet_physiology | 1.57577895 |
| 42 | MP0001853_heart_inflammation | 1.55057031 |
| 43 | MP0003448_altered_tumor_morphology | 1.54190814 |
| 44 | MP0004808_abnormal_hematopoietic_stem | 1.50834800 |
| 45 | MP0005174_abnormal_tail_pigmentation | 1.42449604 |
| 46 | MP0005310_abnormal_salivary_gland | 1.38816003 |
| 47 | MP0005075_abnormal_melanosome_morpholog | 1.35565408 |
| 48 | MP0008877_abnormal_DNA_methylation | 1.34842535 |
| 49 | MP0002998_abnormal_bone_remodeling | 1.32105615 |
| 50 | MP0000490_abnormal_crypts_of | 1.31056001 |
| 51 | MP0003183_abnormal_peptide_metabolism | 1.22327143 |
| 52 | MP0008469_abnormal_protein_level | 1.15894301 |
| 53 | MP0000015_abnormal_ear_pigmentation | 1.14034947 |
| 54 | MP0003300_gastrointestinal_ulcer | 1.11867447 |
| 55 | MP0004130_abnormal_muscle_cell | 1.10603814 |
| 56 | MP0001533_abnormal_skeleton_physiology | 1.09858208 |
| 57 | MP0001545_abnormal_hematopoietic_system | 1.09567281 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 1.09567281 |
| 59 | MP0003646_muscle_fatigue | 1.06066273 |
| 60 | MP0005409_darkened_coat_color | 1.05463085 |
| 61 | MP0001851_eye_inflammation | 1.03883683 |
| 62 | MP0003656_abnormal_erythrocyte_physiolo | 1.03411620 |
| 63 | MP0005377_hearing/vestibular/ear_phenot | 1.02032513 |
| 64 | MP0003878_abnormal_ear_physiology | 1.02032513 |
| 65 | MP0002277_abnormal_respiratory_mucosa | 1.01588641 |
| 66 | MP0008058_abnormal_DNA_repair | 0.96318470 |
| 67 | MP0002138_abnormal_hepatobiliary_system | 0.94731095 |
| 68 | MP0002019_abnormal_tumor_incidence | 0.94662531 |
| 69 | MP0009764_decreased_sensitivity_to | 0.93389511 |
| 70 | MP0002009_preneoplasia | 0.92658343 |
| 71 | MP0008057_abnormal_DNA_replication | 0.91317301 |
| 72 | MP0002876_abnormal_thyroid_physiology | 0.91034385 |
| 73 | MP0000465_gastrointestinal_hemorrhage | 0.90951116 |
| 74 | MP0003172_abnormal_lysosome_physiology | 0.88080420 |
| 75 | MP0003303_peritoneal_inflammation | 0.85426665 |
| 76 | MP0002095_abnormal_skin_pigmentation | 0.84079239 |
| 77 | MP0009278_abnormal_bone_marrow | 0.83290277 |
| 78 | MP0003252_abnormal_bile_duct | 0.82206232 |
| 79 | MP0001501_abnormal_sleep_pattern | 0.81147868 |
| 80 | MP0009763_increased_sensitivity_to | 0.72042068 |
| 81 | MP0010094_abnormal_chromosome_stability | 0.68308367 |
| 82 | MP0008007_abnormal_cellular_replicative | 0.67722987 |
| 83 | MP0001243_abnormal_dermal_layer | 0.66798485 |
| 84 | MP0004883_abnormal_blood_vessel | 0.65454072 |
| 85 | MP0009765_abnormal_xenobiotic_induced | 0.65147227 |
| 86 | MP0003195_calcinosis | 0.63345045 |
| 87 | MP0003077_abnormal_cell_cycle | 0.62904098 |
| 88 | MP0001348_abnormal_lacrimal_gland | 0.62761980 |
| 89 | MP0001919_abnormal_reproductive_system | 0.62019536 |
| 90 | MP0004142_abnormal_muscle_tone | 0.59827540 |
| 91 | MP0003795_abnormal_bone_structure | 0.59503660 |
| 92 | MP0002102_abnormal_ear_morphology | 0.58483444 |
| 93 | MP0004043_abnormal_pH_regulation | 0.58188526 |
| 94 | MP0003787_abnormal_imprinting | 0.58105818 |
| 95 | MP0001663_abnormal_digestive_system | 0.57691129 |
| 96 | MP0001191_abnormal_skin_condition | 0.56375668 |
| 97 | MP0008872_abnormal_physiological_respon | 0.54088306 |
| 98 | MP0005167_abnormal_blood-brain_barrier | 0.53664888 |
| 99 | MP0005645_abnormal_hypothalamus_physiol | 0.52356820 |
| 100 | MP0002163_abnormal_gland_morphology | 0.52186894 |
| 101 | MP0003690_abnormal_glial_cell | 0.51654920 |
| 102 | MP0006072_abnormal_retinal_apoptosis | 0.51456254 |
| 103 | MP0003943_abnormal_hepatobiliary_system | 0.50730011 |
| 104 | MP0005551_abnormal_eye_electrophysiolog | 0.50175083 |
| 105 | MP0000569_abnormal_digit_pigmentation | 0.49879297 |
| 106 | MP0001765_abnormal_ion_homeostasis | 0.49517966 |
| 107 | MP0005390_skeleton_phenotype | 0.49214700 |
| 108 | MP0003045_fibrosis | 0.48768125 |
| 109 | MP0010307_abnormal_tumor_latency | 0.48468844 |
| 110 | MP0002136_abnormal_kidney_physiology | 0.48347637 |
| 111 | MP0004484_altered_response_of | 0.47277905 |
| 112 | MP0000367_abnormal_coat/_hair | 0.47216063 |
| 113 | MP0003191_abnormal_cellular_cholesterol | 0.47076351 |
| 114 | MP0001119_abnormal_female_reproductive | 0.45960707 |
| 115 | MP0000371_diluted_coat_color | 0.45502823 |
| 116 | MP0010329_abnormal_lipoprotein_level | 0.45258686 |
| 117 | MP0000343_altered_response_to | 0.44026020 |
| 118 | MP0003828_pulmonary_edema | 0.43747638 |
| 119 | MP0000249_abnormal_blood_vessel | 0.43219774 |
| 120 | MP0003786_premature_aging | 0.42174802 |
| 121 | MP0005166_decreased_susceptibility_to | 0.42002258 |
| 122 | MP0010352_gastrointestinal_tract_polyps | 0.41195097 |
| 123 | MP0002075_abnormal_coat/hair_pigmentati | 0.41054699 |
| 124 | MP0003453_abnormal_keratinocyte_physiol | 0.40953444 |
| 125 | MP0000477_abnormal_intestine_morphology | 0.40070718 |
| 126 | MP0002693_abnormal_pancreas_physiology | 0.39793243 |
| 127 | MP0001216_abnormal_epidermal_layer | 0.39595281 |
| 128 | MP0001186_pigmentation_phenotype | 0.39156091 |
| 129 | MP0001986_abnormal_taste_sensitivity | 0.38847191 |
| 130 | MP0000609_abnormal_liver_physiology | 0.38034256 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 7.80556765 |
| 2 | Abnormality of T cell number (HP:0011839) | 7.54235198 |
| 3 | Severe combined immunodeficiency (HP:0004430) | 6.36321447 |
| 4 | Combined immunodeficiency (HP:0005387) | 5.69250240 |
| 5 | Optic neuritis (HP:0100653) | 5.42739853 |
| 6 | Retrobulbar optic neuritis (HP:0100654) | 5.42739853 |
| 7 | Myositis (HP:0100614) | 5.09606107 |
| 8 | Thyroiditis (HP:0100646) | 5.08401602 |
| 9 | Abnormality of T cells (HP:0002843) | 4.98775768 |
| 10 | Recurrent fungal infections (HP:0002841) | 4.72176400 |
| 11 | Orchitis (HP:0100796) | 4.71088036 |
| 12 | Panhypogammaglobulinemia (HP:0003139) | 4.53395271 |
| 13 | Abnormality of eosinophils (HP:0001879) | 4.51398533 |
| 14 | Abnormality of B cell number (HP:0010975) | 4.48048928 |
| 15 | B lymphocytopenia (HP:0010976) | 4.48048928 |
| 16 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.45204180 |
| 17 | Recurrent viral infections (HP:0004429) | 4.40802732 |
| 18 | Eosinophilia (HP:0001880) | 4.35030795 |
| 19 | Stomatitis (HP:0010280) | 4.33588430 |
| 20 | IgG deficiency (HP:0004315) | 4.28764827 |
| 21 | Hypoplasia of the thymus (HP:0000778) | 4.07016538 |
| 22 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.03209134 |
| 23 | Recurrent cutaneous fungal infections (HP:0011370) | 4.03209134 |
| 24 | Eczematoid dermatitis (HP:0000976) | 3.95602686 |
| 25 | IgM deficiency (HP:0002850) | 3.80078563 |
| 26 | Granulocytopenia (HP:0001913) | 3.79118028 |
| 27 | Keratoconjunctivitis sicca (HP:0001097) | 3.70994538 |
| 28 | Increased IgM level (HP:0003496) | 3.68805594 |
| 29 | Leukocytosis (HP:0001974) | 3.68461897 |
| 30 | Abnormality of the fingertips (HP:0001211) | 3.59089613 |
| 31 | Encephalitis (HP:0002383) | 3.58688651 |
| 32 | Meningitis (HP:0001287) | 3.55740124 |
| 33 | Chronic diarrhea (HP:0002028) | 3.41495366 |
| 34 | Keratoconjunctivitis (HP:0001096) | 3.40724276 |
| 35 | Recurrent bronchitis (HP:0002837) | 3.35558212 |
| 36 | Hypoproteinemia (HP:0003075) | 3.30992121 |
| 37 | Joint swelling (HP:0001386) | 3.28290606 |
| 38 | Hemoptysis (HP:0002105) | 3.21486261 |
| 39 | Recurrent abscess formation (HP:0002722) | 3.20541535 |
| 40 | Stomach cancer (HP:0012126) | 3.18334192 |
| 41 | Pulmonary infiltrates (HP:0002113) | 3.14839891 |
| 42 | Mediastinal lymphadenopathy (HP:0100721) | 3.13517525 |
| 43 | Vasculitis (HP:0002633) | 3.09196873 |
| 44 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.05021682 |
| 45 | Pustule (HP:0200039) | 3.01774359 |
| 46 | Autoimmune thrombocytopenia (HP:0001973) | 2.96067367 |
| 47 | Lymphopenia (HP:0001888) | 2.80181745 |
| 48 | Lymphoma (HP:0002665) | 2.74519605 |
| 49 | Nasal polyposis (HP:0100582) | 2.73981167 |
| 50 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.70131286 |
| 51 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.67589263 |
| 52 | Abnormality of T cell physiology (HP:0011840) | 2.66930710 |
| 53 | Arterial thrombosis (HP:0004420) | 2.63939851 |
| 54 | Autoimmune hemolytic anemia (HP:0001890) | 2.62582393 |
| 55 | Obstructive lung disease (HP:0006536) | 2.62514085 |
| 56 | Chronic obstructive pulmonary disease (HP:0006510) | 2.62514085 |
| 57 | Recurrent skin infections (HP:0001581) | 2.60224768 |
| 58 | Chronic otitis media (HP:0000389) | 2.54519423 |
| 59 | Recurrent bacterial skin infections (HP:0005406) | 2.50468885 |
| 60 | Abnormality of the prostate (HP:0008775) | 2.43124995 |
| 61 | Cheilitis (HP:0100825) | 2.37605630 |
| 62 | IgA deficiency (HP:0002720) | 2.36661494 |
| 63 | Gastrointestinal infarctions (HP:0005244) | 2.34667682 |
| 64 | Congenital stationary night blindness (HP:0007642) | 2.32219902 |
| 65 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.32047533 |
| 66 | Keratitis (HP:0000491) | 2.28556396 |
| 67 | Hypergammaglobulinemia (HP:0010702) | 2.26130110 |
| 68 | Recurrent sinusitis (HP:0011108) | 2.24456935 |
| 69 | Anorexia (HP:0002039) | 2.23228427 |
| 70 | Alveolar cell carcinoma (HP:0006519) | 2.22918840 |
| 71 | Agammaglobulinemia (HP:0004432) | 2.21773455 |
| 72 | Abnormality of macrophages (HP:0004311) | 2.20747759 |
| 73 | Gangrene (HP:0100758) | 2.18383390 |
| 74 | Chest pain (HP:0100749) | 2.15416371 |
| 75 | Abnormality of the nasal mucosa (HP:0000433) | 2.13702673 |
| 76 | Prolonged bleeding time (HP:0003010) | 2.13239934 |
| 77 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.08101155 |
| 78 | Glomerulopathy (HP:0100820) | 2.06893591 |
| 79 | Petechiae (HP:0000967) | 2.06095932 |
| 80 | Gingivitis (HP:0000230) | 2.05543431 |
| 81 | Pulmonary embolism (HP:0002204) | 2.04539238 |
| 82 | Hemiplegia (HP:0002301) | 2.04269023 |
| 83 | Spontaneous hematomas (HP:0007420) | 2.03600458 |
| 84 | Hematochezia (HP:0002573) | 2.01828421 |
| 85 | Hypochromic anemia (HP:0001931) | 2.01000317 |
| 86 | Renal cortical cysts (HP:0000803) | 2.00509065 |
| 87 | Basal cell carcinoma (HP:0002671) | 1.98828544 |
| 88 | Abnormality of the renal cortex (HP:0011035) | 1.98095583 |
| 89 | Abnormality of the endocardium (HP:0004306) | 1.97748677 |
| 90 | Abnormality of the pleura (HP:0002103) | 1.96860277 |
| 91 | Inflammation of the large intestine (HP:0002037) | 1.96615035 |
| 92 | Increased IgE level (HP:0003212) | 1.96181481 |
| 93 | Periodontitis (HP:0000704) | 1.95228576 |
| 94 | Abnormal hair whorl (HP:0010721) | 1.92371734 |
| 95 | Prostate neoplasm (HP:0100787) | 1.89716285 |
| 96 | Vertigo (HP:0002321) | 1.88599011 |
| 97 | Anhidrosis (HP:0000970) | 1.88491179 |
| 98 | Epistaxis (HP:0000421) | 1.88353276 |
| 99 | Verrucae (HP:0200043) | 1.87544052 |
| 100 | Papilloma (HP:0012740) | 1.87544052 |
| 101 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.86894594 |
| 102 | Pancreatic cysts (HP:0001737) | 1.85398584 |
| 103 | Gastrointestinal inflammation (HP:0004386) | 1.85068302 |
| 104 | Bronchitis (HP:0012387) | 1.83802358 |
| 105 | Colitis (HP:0002583) | 1.83586302 |
| 106 | Polyneuropathy (HP:0001271) | 1.79985680 |
| 107 | Gingival bleeding (HP:0000225) | 1.79558013 |
| 108 | Genetic anticipation (HP:0003743) | 1.78991112 |
| 109 | Pigmentary retinal degeneration (HP:0001146) | 1.75524700 |
| 110 | Conical tooth (HP:0000698) | 1.74890200 |
| 111 | Abnormality of DNA repair (HP:0003254) | 1.74357893 |
| 112 | Increased density of long bones (HP:0006392) | 1.73992347 |
| 113 | Recurrent otitis media (HP:0000403) | 1.73218068 |
| 114 | Slow saccadic eye movements (HP:0000514) | 1.72352830 |
| 115 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.67088533 |
| 116 | Bronchiectasis (HP:0002110) | 1.64389736 |
| 117 | Arthralgia (HP:0002829) | 1.63324528 |
| 118 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.62697792 |
| 119 | Chromsome breakage (HP:0040012) | 1.62501743 |
| 120 | Sepsis (HP:0100806) | 1.62364211 |
| 121 | Abnormal platelet volume (HP:0011876) | 1.62334010 |
| 122 | Persistence of primary teeth (HP:0006335) | 1.62018747 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 5.19708221 |
| 2 | * TXK | 4.77921447 |
| 3 | MAP3K14 | 3.17344705 |
| 4 | ITK | 3.15307925 |
| 5 | IKBKE | 3.02056472 |
| 6 | JAK3 | 2.95597073 |
| 7 | ZAP70 | 2.85267247 |
| 8 | JAK1 | 2.71734572 |
| 9 | IRAK3 | 2.55382983 |
| 10 | FGFR4 | 2.53347894 |
| 11 | NLK | 2.42088232 |
| 12 | TYK2 | 2.34635211 |
| 13 | FGFR3 | 2.20705231 |
| 14 | TEC | 2.20447950 |
| 15 | RIPK4 | 2.07811912 |
| 16 | STK10 | 2.02047366 |
| 17 | FRK | 1.99386698 |
| 18 | SIK3 | 1.96097637 |
| 19 | IRAK4 | 1.90974468 |
| 20 | TBK1 | 1.88661958 |
| 21 | MST4 | 1.87666031 |
| 22 | LCK | 1.87038039 |
| 23 | MAP2K2 | 1.78473271 |
| 24 | GRK6 | 1.62018025 |
| 25 | TAOK3 | 1.60731838 |
| 26 | SYK | 1.57823947 |
| 27 | BTK | 1.56819678 |
| 28 | IKBKB | 1.56204078 |
| 29 | CSK | 1.51315658 |
| 30 | HCK | 1.40629139 |
| 31 | CAMKK2 | 1.38129757 |
| 32 | PIM1 | 1.35424959 |
| 33 | MARK3 | 1.31930742 |
| 34 | CHUK | 1.30394340 |
| 35 | MAP4K2 | 1.25851673 |
| 36 | KIT | 1.24287786 |
| 37 | PRKCQ | 1.20338735 |
| 38 | BLK | 1.15476874 |
| 39 | MAP3K13 | 1.13551750 |
| 40 | CSF1R | 1.13450175 |
| 41 | MAP3K12 | 1.13294236 |
| 42 | MOS | 1.09704128 |
| 43 | EPHA3 | 1.08033818 |
| 44 | ADRBK2 | 1.07472256 |
| 45 | GRK5 | 1.03825900 |
| 46 | TLK1 | 1.00966666 |
| 47 | RPS6KA4 | 1.00247416 |
| 48 | YES1 | 0.98049924 |
| 49 | SIK2 | 0.96049347 |
| 50 | BRD4 | 0.95721263 |
| 51 | PRPF4B | 0.93209719 |
| 52 | MAPK7 | 0.92654886 |
| 53 | TNK2 | 0.90184672 |
| 54 | PRKCH | 0.89837123 |
| 55 | NUAK1 | 0.88804929 |
| 56 | CAMKK1 | 0.87010542 |
| 57 | CDK12 | 0.86431066 |
| 58 | CLK1 | 0.85519345 |
| 59 | PASK | 0.85082159 |
| 60 | MUSK | 0.84958158 |
| 61 | IRAK1 | 0.78579565 |
| 62 | STK24 | 0.78189993 |
| 63 | TSSK6 | 0.77297196 |
| 64 | PDK1 | 0.76599806 |
| 65 | MAP2K3 | 0.74798142 |
| 66 | * LYN | 0.72384487 |
| 67 | GRK7 | 0.71310734 |
| 68 | JAK2 | 0.70747421 |
| 69 | ACVR1B | 0.69837812 |
| 70 | KDR | 0.69454603 |
| 71 | PDGFRB | 0.66796530 |
| 72 | BMPR2 | 0.63815491 |
| 73 | SRPK1 | 0.62950065 |
| 74 | EPHB1 | 0.61566612 |
| 75 | MAP3K7 | 0.60282786 |
| 76 | TGFBR2 | 0.57888699 |
| 77 | STK4 | 0.57878887 |
| 78 | SGK3 | 0.55644059 |
| 79 | ADRBK1 | 0.55362009 |
| 80 | CDK19 | 0.55038721 |
| 81 | PIK3CG | 0.54442364 |
| 82 | OXSR1 | 0.53245403 |
| 83 | SGK2 | 0.52065947 |
| 84 | CDK4 | 0.50979172 |
| 85 | MAPK13 | 0.50426940 |
| 86 | TRPM7 | 0.49783426 |
| 87 | FES | 0.48079775 |
| 88 | FGR | 0.47786965 |
| 89 | RPS6KA5 | 0.47078157 |
| 90 | EIF2AK2 | 0.46778934 |
| 91 | CDK9 | 0.46315918 |
| 92 | PTK2B | 0.42951922 |
| 93 | * FYN | 0.42523313 |
| 94 | GRK1 | 0.40640969 |
| 95 | MAP3K10 | 0.40554571 |
| 96 | INSR | 0.40540903 |
| 97 | MELK | 0.40289803 |
| 98 | MATK | 0.38698642 |
| 99 | MAP2K6 | 0.38105724 |
| 100 | PRKD2 | 0.37389664 |
| 101 | HIPK2 | 0.37176011 |
| 102 | ZAK | 0.36757975 |
| 103 | EEF2K | 0.36308779 |
| 104 | NEK9 | 0.35379826 |
| 105 | WNK4 | 0.35360322 |
| 106 | NME2 | 0.34692958 |
| 107 | STK11 | 0.34562565 |
| 108 | MAPK11 | 0.34042807 |
| 109 | MAPK12 | 0.33770446 |
| 110 | ATR | 0.32784826 |
| 111 | MAPK3 | 0.31901940 |
| 112 | CDK3 | 0.31086106 |
| 113 | MAP3K3 | 0.30738719 |
| 114 | EGFR | 0.30598850 |
| 115 | NEK6 | 0.28082960 |
| 116 | STK38 | 0.27094443 |
| 117 | MAP3K11 | 0.25320046 |
| 118 | MAPKAPK2 | 0.24932368 |
| 119 | MARK2 | 0.24872435 |
| 120 | * IGF1R | 0.24000894 |
| 121 | RPS6KA6 | 0.23447747 |
| 122 | CDK8 | 0.23023640 |
| 123 | FGFR1 | 0.22692967 |
| 124 | CAMK4 | 0.21855896 |
| 125 | RPS6KB1 | 0.21566005 |
| 126 | MAPK4 | 0.21553013 |
| 127 | PRKCD | 0.20980845 |
| 128 | ABL1 | 0.20638041 |
| 129 | MKNK2 | 0.20537558 |
| 130 | INSRR | 0.19762881 |
| 131 | TESK2 | 0.18338877 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.06288713 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.32119758 |
| 3 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.68472414 |
| 4 | Allograft rejection_Homo sapiens_hsa05330 | 3.35086888 |
| 5 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.20878285 |
| 6 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.12897355 |
| 7 | Measles_Homo sapiens_hsa05162 | 2.79119421 |
| 8 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.74474927 |
| 9 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.69847877 |
| 10 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.49200611 |
| 11 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.44078058 |
| 12 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.17805364 |
| 13 | Leishmaniasis_Homo sapiens_hsa05140 | 2.00847705 |
| 14 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.97948860 |
| 15 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.97321205 |
| 16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.92076230 |
| 17 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.84520131 |
| 18 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.75545655 |
| 19 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.66899729 |
| 20 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.59320259 |
| 21 | Viral myocarditis_Homo sapiens_hsa05416 | 1.56627571 |
| 22 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.48487819 |
| 23 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.41092663 |
| 24 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.35357945 |
| 25 | Influenza A_Homo sapiens_hsa05164 | 1.34172464 |
| 26 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.33419506 |
| 27 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.28999468 |
| 28 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.28310282 |
| 29 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.22324642 |
| 30 | Hepatitis B_Homo sapiens_hsa05161 | 1.20785295 |
| 31 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.19833320 |
| 32 | Legionellosis_Homo sapiens_hsa05134 | 1.18021242 |
| 33 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.16170791 |
| 34 | Apoptosis_Homo sapiens_hsa04210 | 1.14927926 |
| 35 | Asthma_Homo sapiens_hsa05310 | 1.07390341 |
| 36 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.05494144 |
| 37 | Malaria_Homo sapiens_hsa05144 | 1.04145890 |
| 38 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.02137106 |
| 39 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.99788896 |
| 40 | HTLV-I infection_Homo sapiens_hsa05166 | 0.98103808 |
| 41 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.97510280 |
| 42 | Phototransduction_Homo sapiens_hsa04744 | 0.97432756 |
| 43 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.93816758 |
| 44 | Tuberculosis_Homo sapiens_hsa05152 | 0.89572523 |
| 45 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.88376172 |
| 46 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.85860146 |
| 47 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.85707796 |
| 48 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.84943410 |
| 49 | * Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.81748357 |
| 50 | Shigellosis_Homo sapiens_hsa05131 | 0.81717873 |
| 51 | Hepatitis C_Homo sapiens_hsa05160 | 0.79292797 |
| 52 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.78691911 |
| 53 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.77206751 |
| 54 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.75601080 |
| 55 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.75239194 |
| 56 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.74839340 |
| 57 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.73125256 |
| 58 | Colorectal cancer_Homo sapiens_hsa05210 | 0.73059320 |
| 59 | Pertussis_Homo sapiens_hsa05133 | 0.72470350 |
| 60 | Salmonella infection_Homo sapiens_hsa05132 | 0.70258398 |
| 61 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.67010855 |
| 62 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.64773397 |
| 63 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.64631968 |
| 64 | Platelet activation_Homo sapiens_hsa04611 | 0.62434462 |
| 65 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.61832811 |
| 66 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.60625639 |
| 67 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.59434863 |
| 68 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.59323918 |
| 69 | Morphine addiction_Homo sapiens_hsa05032 | 0.58706098 |
| 70 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.57179465 |
| 71 | ABC transporters_Homo sapiens_hsa02010 | 0.57098646 |
| 72 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.56637022 |
| 73 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.55054353 |
| 74 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.53247084 |
| 75 | Base excision repair_Homo sapiens_hsa03410 | 0.52891112 |
| 76 | RNA degradation_Homo sapiens_hsa03018 | 0.52713070 |
| 77 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.50640134 |
| 78 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.49833826 |
| 79 | Olfactory transduction_Homo sapiens_hsa04740 | 0.49221187 |
| 80 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.45373951 |
| 81 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.45158919 |
| 82 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.44645293 |
| 83 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.43817225 |
| 84 | Spliceosome_Homo sapiens_hsa03040 | 0.43178243 |
| 85 | RNA polymerase_Homo sapiens_hsa03020 | 0.43100710 |
| 86 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.39881456 |
| 87 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.39091169 |
| 88 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.38857959 |
| 89 | Circadian rhythm_Homo sapiens_hsa04710 | 0.38762276 |
| 90 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.38711216 |
| 91 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.38249822 |
| 92 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.38192880 |
| 93 | Prostate cancer_Homo sapiens_hsa05215 | 0.37441202 |
| 94 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.37268741 |
| 95 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.36962031 |
| 96 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.36619398 |
| 97 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.36049685 |
| 98 | Homologous recombination_Homo sapiens_hsa03440 | 0.35674219 |
| 99 | Taste transduction_Homo sapiens_hsa04742 | 0.34708482 |
| 100 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.34129719 |
| 101 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.33782610 |
| 102 | Basal transcription factors_Homo sapiens_hsa03022 | 0.33508907 |
| 103 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.33463295 |
| 104 | Insulin resistance_Homo sapiens_hsa04931 | 0.33258227 |
| 105 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32154513 |
| 106 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.31361520 |
| 107 | Endocytosis_Homo sapiens_hsa04144 | 0.30513377 |
| 108 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.29778511 |
| 109 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.29768286 |
| 110 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.29349434 |
| 111 | Salivary secretion_Homo sapiens_hsa04970 | 0.29154873 |
| 112 | Endometrial cancer_Homo sapiens_hsa05213 | 0.28870334 |
| 113 | Renin secretion_Homo sapiens_hsa04924 | 0.28654938 |
| 114 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.26915079 |
| 115 | Other glycan degradation_Homo sapiens_hsa00511 | 0.26584174 |
| 116 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.26165201 |
| 117 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.24315073 |
| 118 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.24146556 |
| 119 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.22824312 |
| 120 | Thyroid cancer_Homo sapiens_hsa05216 | 0.21693266 |
| 121 | Pathways in cancer_Homo sapiens_hsa05200 | 0.21132222 |
| 122 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.20601084 |
| 123 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.19340951 |
| 124 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.18827143 |
| 125 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.18690771 |
| 126 | Adherens junction_Homo sapiens_hsa04520 | 0.18356173 |
| 127 | Mismatch repair_Homo sapiens_hsa03430 | 0.17817140 |
| 128 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.16253258 |
| 129 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.15821931 |
| 130 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.15785392 |
| 131 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.14447318 |
| 132 | Cell cycle_Homo sapiens_hsa04110 | 0.13142380 |
| 133 | DNA replication_Homo sapiens_hsa03030 | 0.11582648 |

