TXK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.28158864
2positive regulation of gamma-delta T cell activation (GO:0046645)7.01794622
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.88613456
4negative regulation of cell killing (GO:0031342)6.88613456
5positive T cell selection (GO:0043368)6.61889568
6negative thymic T cell selection (GO:0045060)6.55047779
7cellular response to interleukin-15 (GO:0071350)6.41051066
8positive thymic T cell selection (GO:0045059)6.07111100
9* interferon-gamma production (GO:0032609)6.03455532
10regulation of gamma-delta T cell differentiation (GO:0045586)5.92586976
11response to interleukin-15 (GO:0070672)5.91004747
12T cell selection (GO:0045058)5.74518925
13regulation of gamma-delta T cell activation (GO:0046643)5.71730546
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.59517815
15thymic T cell selection (GO:0045061)5.47827160
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.44651849
17regulation of isotype switching to IgG isotypes (GO:0048302)5.35784123
18leukocyte aggregation (GO:0070486)5.12249100
19T cell migration (GO:0072678)5.04507960
20activated T cell proliferation (GO:0050798)4.90336905
21regulation of T cell tolerance induction (GO:0002664)4.63942993
22* T cell receptor signaling pathway (GO:0050852)4.63796189
23regulation of B cell receptor signaling pathway (GO:0050855)4.39255966
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.20823531
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20823531
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.19816729
27regulation of natural killer cell mediated immunity (GO:0002715)4.19816729
28T cell costimulation (GO:0031295)4.19091346
29positive regulation of alpha-beta T cell proliferation (GO:0046641)4.17229060
30T-helper cell differentiation (GO:0042093)4.17027194
31CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.17027194
32lymphocyte costimulation (GO:0031294)4.14031239
33regulation of alpha-beta T cell proliferation (GO:0046640)4.13791037
34regulation of interleukin-2 biosynthetic process (GO:0045076)4.13617706
35positive regulation of granulocyte differentiation (GO:0030854)4.12903749
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.09907939
37tolerance induction (GO:0002507)4.02910625
38T cell differentiation involved in immune response (GO:0002292)4.02892258
39alpha-beta T cell differentiation involved in immune response (GO:0002293)4.02892258
40alpha-beta T cell activation involved in immune response (GO:0002287)4.02892258
41* alpha-beta T cell differentiation (GO:0046632)4.02114745
42positive regulation of isotype switching (GO:0045830)4.00909253
43positive regulation of interleukin-2 production (GO:0032743)4.00384042
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98992457
45* alpha-beta T cell activation (GO:0046631)3.97837356
46regulation of T cell receptor signaling pathway (GO:0050856)3.97578502
47* antigen receptor-mediated signaling pathway (GO:0050851)3.96660437
48regulation of leukocyte mediated cytotoxicity (GO:0001910)3.94352528
49negative regulation of T cell mediated immunity (GO:0002710)3.93365403
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.86675383
51* T cell differentiation (GO:0030217)3.84778863
52regulation of cell killing (GO:0031341)3.84107583
53mast cell activation (GO:0045576)3.82957068
54positive regulation of natural killer cell mediated immunity (GO:0002717)3.78150985
55positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.78150985
56natural killer cell activation (GO:0030101)3.74202214
57positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.72905409
58regulation of T cell mediated cytotoxicity (GO:0001914)3.72172045
59negative regulation of leukocyte mediated immunity (GO:0002704)3.72170883
60antigen processing and presentation of endogenous antigen (GO:0019883)3.68643908
61positive regulation of DNA recombination (GO:0045911)3.67941915
62positive regulation of B cell mediated immunity (GO:0002714)3.66332365
63positive regulation of immunoglobulin mediated immune response (GO:0002891)3.66332365
64CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.63013781
65positive regulation of T cell mediated cytotoxicity (GO:0001916)3.62395182
66positive regulation of cell killing (GO:0031343)3.61392354
67positive regulation of tolerance induction (GO:0002645)3.58802106
68regulation of interleukin-12 biosynthetic process (GO:0045075)3.58291397
69positive regulation of humoral immune response (GO:0002922)3.55305319
70cell wall macromolecule catabolic process (GO:0016998)3.53708777
71regulation of isotype switching (GO:0045191)3.48272654
72mast cell activation involved in immune response (GO:0002279)3.43092922
73mast cell degranulation (GO:0043303)3.43092922
74regulation of tolerance induction (GO:0002643)3.42242328
75NIK/NF-kappaB signaling (GO:0038061)3.40554718
76T cell activation involved in immune response (GO:0002286)3.38047553
77negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.35514894
78antigen processing and presentation via MHC class Ib (GO:0002475)3.34868883
79B cell receptor signaling pathway (GO:0050853)3.33688917
80CD4-positive, alpha-beta T cell activation (GO:0035710)3.32467336
81V(D)J recombination (GO:0033151)3.32264393
82response to muramyl dipeptide (GO:0032495)3.30741279
83* T cell activation (GO:0042110)3.30604428
84negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.30362548
85cellular defense response (GO:0006968)3.29440327
86regulation of T cell mediated immunity (GO:0002709)3.27828061
87regulation of immunoglobulin mediated immune response (GO:0002889)3.27742785
88positive regulation of T cell differentiation in thymus (GO:0033089)3.23687497
89positive regulation of T cell mediated immunity (GO:0002711)3.22179938
90sequestering of actin monomers (GO:0042989)3.22077327
91leukocyte cell-cell adhesion (GO:0007159)3.20915011
92negative regulation of innate immune response (GO:0045824)3.19916343
93regulation of memory T cell differentiation (GO:0043380)3.19118141
94regulation of B cell mediated immunity (GO:0002712)3.18363128
95response to type I interferon (GO:0034340)3.15189660
96lymph node development (GO:0048535)3.12967794
97T cell homeostasis (GO:0043029)3.12706555
98positive regulation of defense response to virus by host (GO:0002230)3.11543970
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.11134918
100negative regulation of lymphocyte mediated immunity (GO:0002707)3.10350457
101myeloid dendritic cell activation (GO:0001773)3.09436161
102regulation of interleukin-2 production (GO:0032663)3.08810170
103mucosal-associated lymphoid tissue development (GO:0048537)3.07699418
104Peyers patch development (GO:0048541)3.07699418
105cellular response to type I interferon (GO:0071357)3.07682255
106type I interferon signaling pathway (GO:0060337)3.07682255
107regulation of regulatory T cell differentiation (GO:0045589)3.07634248
108negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.07125472
109cell wall macromolecule metabolic process (GO:0044036)3.04589726
110* regulation of response to interferon-gamma (GO:0060330)3.03618420
111negative regulation of adaptive immune response (GO:0002820)3.01622193
112regulation of lymphocyte mediated immunity (GO:0002706)3.01208843
113regulation of B cell differentiation (GO:0045577)3.00319594
114* positive regulation of interferon-gamma production (GO:0032729)2.99539640
115positive regulation of lymphocyte mediated immunity (GO:0002708)2.99345947
116positive regulation of B cell differentiation (GO:0045579)2.98586841
117regulation of activation of Janus kinase activity (GO:0010533)2.98365229
118regulation of alpha-beta T cell activation (GO:0046634)2.97371939
119* regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.97213991
120positive regulation of T cell cytokine production (GO:0002726)2.96971306
121lymphocyte homeostasis (GO:0002260)2.95670862
122leukocyte degranulation (GO:0043299)2.94416432
123positive regulation of T-helper 1 type immune response (GO:0002827)2.94190223
124protein K11-linked deubiquitination (GO:0035871)2.89512837
125natural killer cell differentiation (GO:0001779)2.89500999
126regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.86600595
127positive regulation of alpha-beta T cell activation (GO:0046635)2.86574771
128negative regulation of T-helper cell differentiation (GO:0045623)2.85885621
129negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85885621
130positive regulation of natural killer cell differentiation (GO:0032825)2.83315193
131positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.80967654
132T cell proliferation (GO:0042098)2.78284108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.76486612
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.81232249
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.77970372
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.44184076
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.40752715
6RUNX_20019798_ChIP-Seq_JUKART_Human3.93082305
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.85117416
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.81511468
9* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.76954450
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.39850396
11* MYB_26560356_Chip-Seq_TH2_Human3.34084569
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14630822
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.84055207
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.80965868
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76432815
16MYB_26560356_Chip-Seq_TH1_Human2.67211359
17MAF_26560356_Chip-Seq_TH1_Human2.53179653
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42937439
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.34245173
20MYC_22102868_ChIP-Seq_BL_Human2.33946673
21E2F7_22180533_ChIP-Seq_HELA_Human2.33215347
22* IRF8_27001747_Chip-Seq_BMDM_Mouse2.29624513
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28261176
24* UTX_26944678_Chip-Seq_JUKART_Human2.22050913
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.19172542
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12914286
27GATA3_27048872_Chip-Seq_THYMUS_Human2.07526734
28SCL_19346495_ChIP-Seq_HPC-7_Human1.99215274
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98283769
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.91403590
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89598099
32SPI1_23547873_ChIP-Seq_NB4_Human1.88885531
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86775602
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77089634
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75219345
36RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.71819433
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66945150
38MAF_26560356_Chip-Seq_TH2_Human1.66033828
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65795718
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61597168
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60215162
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47239276
43VDR_21846776_ChIP-Seq_THP-1_Human1.45233224
44GATA3_26560356_Chip-Seq_TH2_Human1.43532257
45TCF7_22412390_ChIP-Seq_EML_Mouse1.40422803
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39793143
47VDR_24763502_ChIP-Seq_THP-1_Human1.38585041
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37967422
49PU_27001747_Chip-Seq_BMDM_Mouse1.37825933
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35635151
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35453238
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29430844
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27849904
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23157368
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21952485
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20865353
57SPI1_23127762_ChIP-Seq_K562_Human1.20670057
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15915856
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14573012
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14558138
61GATA3_26560356_Chip-Seq_TH1_Human1.12334732
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.11259809
63SMRT_27268052_Chip-Seq_Bcells_Human1.11128619
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10909554
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09909726
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09642373
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09499851
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08927604
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.07314185
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05521341
71VDR_24787735_ChIP-Seq_THP-1_Human1.04438130
72VDR_23849224_ChIP-Seq_CD4+_Human1.03923950
73* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01519280
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00963508
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00003114
76CIITA_25753668_ChIP-Seq_RAJI_Human0.99617586
77IRF1_19129219_ChIP-ChIP_H3396_Human0.99435460
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98898148
79* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97499616
80* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97225431
81* GATA2_21666600_ChIP-Seq_HMVEC_Human0.96561081
82ELK1_19687146_ChIP-ChIP_HELA_Human0.95600475
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93362519
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93080776
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.93057894
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91475882
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88766521
88FOXP3_21729870_ChIP-Seq_TREG_Human0.87740449
89ER_23166858_ChIP-Seq_MCF-7_Human0.87532853
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87157471
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86965777
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86451897
93STAT1_20625510_ChIP-Seq_HELA_Human0.85349106
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85238417
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84509848
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84363282
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84195753
98P300_27268052_Chip-Seq_Bcells_Human0.81603324
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81559861
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81285261
101KDM2B_26808549_Chip-Seq_DND41_Human0.80493486
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.79163907
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78019772
104BCL6_27268052_Chip-Seq_Bcells_Human0.77866224
105PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77736301
106EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75333929
107CRX_20693478_ChIP-Seq_RETINA_Mouse0.75295817
108VDR_22108803_ChIP-Seq_LS180_Human0.74945814
109* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74598197
110ZNF274_21170338_ChIP-Seq_K562_Hela0.74321726
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73806808
112SPI1_20517297_ChIP-Seq_HL60_Human0.73027721
113FOXA1_21572438_ChIP-Seq_LNCaP_Human0.72740325
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.72727463
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.71756079
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69904819
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69119517
118* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68125285
119E2F4_17652178_ChIP-ChIP_JURKAT_Human0.65769481
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.63688882
121RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63553016
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63004498
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62948568
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62846043
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.62005789
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.60709437
127ETS1_22383799_ChIP-Seq_G1ME_Mouse0.60488926
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.59668786
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.58746325
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.57830082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.15195979
2MP0005671_abnormal_response_to5.01652047
3MP0001835_abnormal_antigen_presentation3.66560305
4MP0009785_altered_susceptibility_to3.40550815
5MP0000685_abnormal_immune_system3.23689695
6MP0001800_abnormal_humoral_immune3.16974516
7MP0006082_CNS_inflammation3.16015851
8MP0001790_abnormal_immune_system3.08934531
9MP0005387_immune_system_phenotype3.08934531
10MP0005000_abnormal_immune_tolerance3.05477306
11MP0002420_abnormal_adaptive_immunity2.88366419
12* MP0002723_abnormal_immune_serum2.86654762
13MP0001819_abnormal_immune_cell2.86327190
14MP0002166_altered_tumor_susceptibility2.79674949
15MP0003724_increased_susceptibility_to2.77039154
16MP0002398_abnormal_bone_marrow2.68736140
17MP0002006_tumorigenesis2.65864254
18MP0002452_abnormal_antigen_presenting2.64726409
19MP0002405_respiratory_system_inflammati2.63262167
20MP0009333_abnormal_splenocyte_physiolog2.62625012
21MP0000703_abnormal_thymus_morphology2.62597650
22* MP0005025_abnormal_response_to2.58896682
23MP0002148_abnormal_hypersensitivity_rea2.40744208
24MP0000716_abnormal_immune_system2.40572272
25MP0010155_abnormal_intestine_physiology2.40215231
26MP0002722_abnormal_immune_system2.21683636
27MP0003436_decreased_susceptibility_to2.16866740
28MP0004947_skin_inflammation2.16260081
29MP0002419_abnormal_innate_immunity2.15750796
30MP0001873_stomach_inflammation2.10823568
31MP0000689_abnormal_spleen_morphology2.08348262
32MP0002132_abnormal_respiratory_system1.96234255
33MP0002429_abnormal_blood_cell1.91538473
34MP0003866_abnormal_defecation1.83892560
35MP0001845_abnormal_inflammatory_respons1.83266422
36MP0000858_altered_metastatic_potential1.80346548
37MP0002396_abnormal_hematopoietic_system1.79330270
38MP0002933_joint_inflammation1.79096841
39MP0004381_abnormal_hair_follicle1.76981838
40MP0004510_myositis1.75806676
41MP0005464_abnormal_platelet_physiology1.57577895
42MP0001853_heart_inflammation1.55057031
43MP0003448_altered_tumor_morphology1.54190814
44MP0004808_abnormal_hematopoietic_stem1.50834800
45MP0005174_abnormal_tail_pigmentation1.42449604
46MP0005310_abnormal_salivary_gland1.38816003
47MP0005075_abnormal_melanosome_morpholog1.35565408
48MP0008877_abnormal_DNA_methylation1.34842535
49MP0002998_abnormal_bone_remodeling1.32105615
50MP0000490_abnormal_crypts_of1.31056001
51MP0003183_abnormal_peptide_metabolism1.22327143
52MP0008469_abnormal_protein_level1.15894301
53MP0000015_abnormal_ear_pigmentation1.14034947
54MP0003300_gastrointestinal_ulcer1.11867447
55MP0004130_abnormal_muscle_cell1.10603814
56MP0001533_abnormal_skeleton_physiology1.09858208
57MP0001545_abnormal_hematopoietic_system1.09567281
58MP0005397_hematopoietic_system_phenotyp1.09567281
59MP0003646_muscle_fatigue1.06066273
60MP0005409_darkened_coat_color1.05463085
61MP0001851_eye_inflammation1.03883683
62MP0003656_abnormal_erythrocyte_physiolo1.03411620
63MP0005377_hearing/vestibular/ear_phenot1.02032513
64MP0003878_abnormal_ear_physiology1.02032513
65MP0002277_abnormal_respiratory_mucosa1.01588641
66MP0008058_abnormal_DNA_repair0.96318470
67MP0002138_abnormal_hepatobiliary_system0.94731095
68MP0002019_abnormal_tumor_incidence0.94662531
69MP0009764_decreased_sensitivity_to0.93389511
70MP0002009_preneoplasia0.92658343
71MP0008057_abnormal_DNA_replication0.91317301
72MP0002876_abnormal_thyroid_physiology0.91034385
73MP0000465_gastrointestinal_hemorrhage0.90951116
74MP0003172_abnormal_lysosome_physiology0.88080420
75MP0003303_peritoneal_inflammation0.85426665
76MP0002095_abnormal_skin_pigmentation0.84079239
77MP0009278_abnormal_bone_marrow0.83290277
78MP0003252_abnormal_bile_duct0.82206232
79MP0001501_abnormal_sleep_pattern0.81147868
80MP0009763_increased_sensitivity_to0.72042068
81MP0010094_abnormal_chromosome_stability0.68308367
82MP0008007_abnormal_cellular_replicative0.67722987
83MP0001243_abnormal_dermal_layer0.66798485
84MP0004883_abnormal_blood_vessel0.65454072
85MP0009765_abnormal_xenobiotic_induced0.65147227
86MP0003195_calcinosis0.63345045
87MP0003077_abnormal_cell_cycle0.62904098
88MP0001348_abnormal_lacrimal_gland0.62761980
89MP0001919_abnormal_reproductive_system0.62019536
90MP0004142_abnormal_muscle_tone0.59827540
91MP0003795_abnormal_bone_structure0.59503660
92MP0002102_abnormal_ear_morphology0.58483444
93MP0004043_abnormal_pH_regulation0.58188526
94MP0003787_abnormal_imprinting0.58105818
95MP0001663_abnormal_digestive_system0.57691129
96MP0001191_abnormal_skin_condition0.56375668
97MP0008872_abnormal_physiological_respon0.54088306
98MP0005167_abnormal_blood-brain_barrier0.53664888
99MP0005645_abnormal_hypothalamus_physiol0.52356820
100MP0002163_abnormal_gland_morphology0.52186894
101MP0003690_abnormal_glial_cell0.51654920
102MP0006072_abnormal_retinal_apoptosis0.51456254
103MP0003943_abnormal_hepatobiliary_system0.50730011
104MP0005551_abnormal_eye_electrophysiolog0.50175083
105MP0000569_abnormal_digit_pigmentation0.49879297
106MP0001765_abnormal_ion_homeostasis0.49517966
107MP0005390_skeleton_phenotype0.49214700
108MP0003045_fibrosis0.48768125
109MP0010307_abnormal_tumor_latency0.48468844
110MP0002136_abnormal_kidney_physiology0.48347637
111MP0004484_altered_response_of0.47277905
112MP0000367_abnormal_coat/_hair0.47216063
113MP0003191_abnormal_cellular_cholesterol0.47076351
114MP0001119_abnormal_female_reproductive0.45960707
115MP0000371_diluted_coat_color0.45502823
116MP0010329_abnormal_lipoprotein_level0.45258686
117MP0000343_altered_response_to0.44026020
118MP0003828_pulmonary_edema0.43747638
119MP0000249_abnormal_blood_vessel0.43219774
120MP0003786_premature_aging0.42174802
121MP0005166_decreased_susceptibility_to0.42002258
122MP0010352_gastrointestinal_tract_polyps0.41195097
123MP0002075_abnormal_coat/hair_pigmentati0.41054699
124MP0003453_abnormal_keratinocyte_physiol0.40953444
125MP0000477_abnormal_intestine_morphology0.40070718
126MP0002693_abnormal_pancreas_physiology0.39793243
127MP0001216_abnormal_epidermal_layer0.39595281
128MP0001186_pigmentation_phenotype0.39156091
129MP0001986_abnormal_taste_sensitivity0.38847191
130MP0000609_abnormal_liver_physiology0.38034256

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.80556765
2Abnormality of T cell number (HP:0011839)7.54235198
3Severe combined immunodeficiency (HP:0004430)6.36321447
4Combined immunodeficiency (HP:0005387)5.69250240
5Optic neuritis (HP:0100653)5.42739853
6Retrobulbar optic neuritis (HP:0100654)5.42739853
7Myositis (HP:0100614)5.09606107
8Thyroiditis (HP:0100646)5.08401602
9Abnormality of T cells (HP:0002843)4.98775768
10Recurrent fungal infections (HP:0002841)4.72176400
11Orchitis (HP:0100796)4.71088036
12Panhypogammaglobulinemia (HP:0003139)4.53395271
13Abnormality of eosinophils (HP:0001879)4.51398533
14Abnormality of B cell number (HP:0010975)4.48048928
15B lymphocytopenia (HP:0010976)4.48048928
16Elevated erythrocyte sedimentation rate (HP:0003565)4.45204180
17Recurrent viral infections (HP:0004429)4.40802732
18Eosinophilia (HP:0001880)4.35030795
19Stomatitis (HP:0010280)4.33588430
20IgG deficiency (HP:0004315)4.28764827
21Hypoplasia of the thymus (HP:0000778)4.07016538
22Chronic mucocutaneous candidiasis (HP:0002728)4.03209134
23Recurrent cutaneous fungal infections (HP:0011370)4.03209134
24Eczematoid dermatitis (HP:0000976)3.95602686
25IgM deficiency (HP:0002850)3.80078563
26Granulocytopenia (HP:0001913)3.79118028
27Keratoconjunctivitis sicca (HP:0001097)3.70994538
28Increased IgM level (HP:0003496)3.68805594
29Leukocytosis (HP:0001974)3.68461897
30Abnormality of the fingertips (HP:0001211)3.59089613
31Encephalitis (HP:0002383)3.58688651
32Meningitis (HP:0001287)3.55740124
33Chronic diarrhea (HP:0002028)3.41495366
34Keratoconjunctivitis (HP:0001096)3.40724276
35Recurrent bronchitis (HP:0002837)3.35558212
36Hypoproteinemia (HP:0003075)3.30992121
37Joint swelling (HP:0001386)3.28290606
38Hemoptysis (HP:0002105)3.21486261
39Recurrent abscess formation (HP:0002722)3.20541535
40Stomach cancer (HP:0012126)3.18334192
41Pulmonary infiltrates (HP:0002113)3.14839891
42Mediastinal lymphadenopathy (HP:0100721)3.13517525
43Vasculitis (HP:0002633)3.09196873
44Abnormal delayed hypersensitivity skin test (HP:0002963)3.05021682
45Pustule (HP:0200039)3.01774359
46Autoimmune thrombocytopenia (HP:0001973)2.96067367
47Lymphopenia (HP:0001888)2.80181745
48Lymphoma (HP:0002665)2.74519605
49Nasal polyposis (HP:0100582)2.73981167
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.70131286
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67589263
52Abnormality of T cell physiology (HP:0011840)2.66930710
53Arterial thrombosis (HP:0004420)2.63939851
54Autoimmune hemolytic anemia (HP:0001890)2.62582393
55Obstructive lung disease (HP:0006536)2.62514085
56Chronic obstructive pulmonary disease (HP:0006510)2.62514085
57Recurrent skin infections (HP:0001581)2.60224768
58Chronic otitis media (HP:0000389)2.54519423
59Recurrent bacterial skin infections (HP:0005406)2.50468885
60Abnormality of the prostate (HP:0008775)2.43124995
61Cheilitis (HP:0100825)2.37605630
62IgA deficiency (HP:0002720)2.36661494
63Gastrointestinal infarctions (HP:0005244)2.34667682
64Congenital stationary night blindness (HP:0007642)2.32219902
65Abnormal rod and cone electroretinograms (HP:0008323)2.32047533
66Keratitis (HP:0000491)2.28556396
67Hypergammaglobulinemia (HP:0010702)2.26130110
68Recurrent sinusitis (HP:0011108)2.24456935
69Anorexia (HP:0002039)2.23228427
70Alveolar cell carcinoma (HP:0006519)2.22918840
71Agammaglobulinemia (HP:0004432)2.21773455
72Abnormality of macrophages (HP:0004311)2.20747759
73Gangrene (HP:0100758)2.18383390
74Chest pain (HP:0100749)2.15416371
75Abnormality of the nasal mucosa (HP:0000433)2.13702673
76Prolonged bleeding time (HP:0003010)2.13239934
77Neoplasm of the tracheobronchial system (HP:0100552)2.08101155
78Glomerulopathy (HP:0100820)2.06893591
79Petechiae (HP:0000967)2.06095932
80Gingivitis (HP:0000230)2.05543431
81Pulmonary embolism (HP:0002204)2.04539238
82Hemiplegia (HP:0002301)2.04269023
83Spontaneous hematomas (HP:0007420)2.03600458
84Hematochezia (HP:0002573)2.01828421
85Hypochromic anemia (HP:0001931)2.01000317
86Renal cortical cysts (HP:0000803)2.00509065
87Basal cell carcinoma (HP:0002671)1.98828544
88Abnormality of the renal cortex (HP:0011035)1.98095583
89Abnormality of the endocardium (HP:0004306)1.97748677
90Abnormality of the pleura (HP:0002103)1.96860277
91Inflammation of the large intestine (HP:0002037)1.96615035
92Increased IgE level (HP:0003212)1.96181481
93Periodontitis (HP:0000704)1.95228576
94Abnormal hair whorl (HP:0010721)1.92371734
95Prostate neoplasm (HP:0100787)1.89716285
96Vertigo (HP:0002321)1.88599011
97Anhidrosis (HP:0000970)1.88491179
98Epistaxis (HP:0000421)1.88353276
99Verrucae (HP:0200043)1.87544052
100Papilloma (HP:0012740)1.87544052
101Aplasia/Hypoplasia of the thymus (HP:0010515)1.86894594
102Pancreatic cysts (HP:0001737)1.85398584
103Gastrointestinal inflammation (HP:0004386)1.85068302
104Bronchitis (HP:0012387)1.83802358
105Colitis (HP:0002583)1.83586302
106Polyneuropathy (HP:0001271)1.79985680
107Gingival bleeding (HP:0000225)1.79558013
108Genetic anticipation (HP:0003743)1.78991112
109Pigmentary retinal degeneration (HP:0001146)1.75524700
110Conical tooth (HP:0000698)1.74890200
111Abnormality of DNA repair (HP:0003254)1.74357893
112Increased density of long bones (HP:0006392)1.73992347
113Recurrent otitis media (HP:0000403)1.73218068
114Slow saccadic eye movements (HP:0000514)1.72352830
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67088533
116Bronchiectasis (HP:0002110)1.64389736
117Arthralgia (HP:0002829)1.63324528
118Recurrent gram-negative bacterial infections (HP:0005420)1.62697792
119Chromsome breakage (HP:0040012)1.62501743
120Sepsis (HP:0100806)1.62364211
121Abnormal platelet volume (HP:0011876)1.62334010
122Persistence of primary teeth (HP:0006335)1.62018747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.19708221
2* TXK4.77921447
3MAP3K143.17344705
4ITK3.15307925
5IKBKE3.02056472
6JAK32.95597073
7ZAP702.85267247
8JAK12.71734572
9IRAK32.55382983
10FGFR42.53347894
11NLK2.42088232
12TYK22.34635211
13FGFR32.20705231
14TEC2.20447950
15RIPK42.07811912
16STK102.02047366
17FRK1.99386698
18SIK31.96097637
19IRAK41.90974468
20TBK11.88661958
21MST41.87666031
22LCK1.87038039
23MAP2K21.78473271
24GRK61.62018025
25TAOK31.60731838
26SYK1.57823947
27BTK1.56819678
28IKBKB1.56204078
29CSK1.51315658
30HCK1.40629139
31CAMKK21.38129757
32PIM11.35424959
33MARK31.31930742
34CHUK1.30394340
35MAP4K21.25851673
36KIT1.24287786
37PRKCQ1.20338735
38BLK1.15476874
39MAP3K131.13551750
40CSF1R1.13450175
41MAP3K121.13294236
42MOS1.09704128
43EPHA31.08033818
44ADRBK21.07472256
45GRK51.03825900
46TLK11.00966666
47RPS6KA41.00247416
48YES10.98049924
49SIK20.96049347
50BRD40.95721263
51PRPF4B0.93209719
52MAPK70.92654886
53TNK20.90184672
54PRKCH0.89837123
55NUAK10.88804929
56CAMKK10.87010542
57CDK120.86431066
58CLK10.85519345
59PASK0.85082159
60MUSK0.84958158
61IRAK10.78579565
62STK240.78189993
63TSSK60.77297196
64PDK10.76599806
65MAP2K30.74798142
66* LYN0.72384487
67GRK70.71310734
68JAK20.70747421
69ACVR1B0.69837812
70KDR0.69454603
71PDGFRB0.66796530
72BMPR20.63815491
73SRPK10.62950065
74EPHB10.61566612
75MAP3K70.60282786
76TGFBR20.57888699
77STK40.57878887
78SGK30.55644059
79ADRBK10.55362009
80CDK190.55038721
81PIK3CG0.54442364
82OXSR10.53245403
83SGK20.52065947
84CDK40.50979172
85MAPK130.50426940
86TRPM70.49783426
87FES0.48079775
88FGR0.47786965
89RPS6KA50.47078157
90EIF2AK20.46778934
91CDK90.46315918
92PTK2B0.42951922
93* FYN0.42523313
94GRK10.40640969
95MAP3K100.40554571
96INSR0.40540903
97MELK0.40289803
98MATK0.38698642
99MAP2K60.38105724
100PRKD20.37389664
101HIPK20.37176011
102ZAK0.36757975
103EEF2K0.36308779
104NEK90.35379826
105WNK40.35360322
106NME20.34692958
107STK110.34562565
108MAPK110.34042807
109MAPK120.33770446
110ATR0.32784826
111MAPK30.31901940
112CDK30.31086106
113MAP3K30.30738719
114EGFR0.30598850
115NEK60.28082960
116STK380.27094443
117MAP3K110.25320046
118MAPKAPK20.24932368
119MARK20.24872435
120* IGF1R0.24000894
121RPS6KA60.23447747
122CDK80.23023640
123FGFR10.22692967
124CAMK40.21855896
125RPS6KB10.21566005
126MAPK40.21553013
127PRKCD0.20980845
128ABL10.20638041
129MKNK20.20537558
130INSRR0.19762881
131TESK20.18338877

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.06288713
2Graft-versus-host disease_Homo sapiens_hsa053324.32119758
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.68472414
4Allograft rejection_Homo sapiens_hsa053303.35086888
5T cell receptor signaling pathway_Homo sapiens_hsa046603.20878285
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.12897355
7Measles_Homo sapiens_hsa051622.79119421
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.74474927
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.69847877
10Antigen processing and presentation_Homo sapiens_hsa046122.49200611
11Autoimmune thyroid disease_Homo sapiens_hsa053202.44078058
12Hematopoietic cell lineage_Homo sapiens_hsa046402.17805364
13Leishmaniasis_Homo sapiens_hsa051402.00847705
14Osteoclast differentiation_Homo sapiens_hsa043801.97948860
15Type I diabetes mellitus_Homo sapiens_hsa049401.97321205
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92076230
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.84520131
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75545655
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66899729
20Herpes simplex infection_Homo sapiens_hsa051681.59320259
21Viral myocarditis_Homo sapiens_hsa054161.56627571
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48487819
23TNF signaling pathway_Homo sapiens_hsa046681.41092663
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35357945
25Influenza A_Homo sapiens_hsa051641.34172464
26B cell receptor signaling pathway_Homo sapiens_hsa046621.33419506
27Toxoplasmosis_Homo sapiens_hsa051451.28999468
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28310282
29Chemokine signaling pathway_Homo sapiens_hsa040621.22324642
30Hepatitis B_Homo sapiens_hsa051611.20785295
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19833320
32Legionellosis_Homo sapiens_hsa051341.18021242
33Acute myeloid leukemia_Homo sapiens_hsa052211.16170791
34Apoptosis_Homo sapiens_hsa042101.14927926
35Asthma_Homo sapiens_hsa053101.07390341
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05494144
37Malaria_Homo sapiens_hsa051441.04145890
38Linoleic acid metabolism_Homo sapiens_hsa005911.02137106
39Rheumatoid arthritis_Homo sapiens_hsa053230.99788896
40HTLV-I infection_Homo sapiens_hsa051660.98103808
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97510280
42Phototransduction_Homo sapiens_hsa047440.97432756
43Non-homologous end-joining_Homo sapiens_hsa034500.93816758
44Tuberculosis_Homo sapiens_hsa051520.89572523
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88376172
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85860146
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85707796
48Epstein-Barr virus infection_Homo sapiens_hsa051690.84943410
49* Leukocyte transendothelial migration_Homo sapiens_hsa046700.81748357
50Shigellosis_Homo sapiens_hsa051310.81717873
51Hepatitis C_Homo sapiens_hsa051600.79292797
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78691911
53Regulation of autophagy_Homo sapiens_hsa041400.77206751
54Staphylococcus aureus infection_Homo sapiens_hsa051500.75601080
55Pancreatic cancer_Homo sapiens_hsa052120.75239194
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74839340
57Prolactin signaling pathway_Homo sapiens_hsa049170.73125256
58Colorectal cancer_Homo sapiens_hsa052100.73059320
59Pertussis_Homo sapiens_hsa051330.72470350
60Salmonella infection_Homo sapiens_hsa051320.70258398
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67010855
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64773397
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64631968
64Platelet activation_Homo sapiens_hsa046110.62434462
65p53 signaling pathway_Homo sapiens_hsa041150.61832811
66FoxO signaling pathway_Homo sapiens_hsa040680.60625639
67Viral carcinogenesis_Homo sapiens_hsa052030.59434863
68Chronic myeloid leukemia_Homo sapiens_hsa052200.59323918
69Morphine addiction_Homo sapiens_hsa050320.58706098
70Fanconi anemia pathway_Homo sapiens_hsa034600.57179465
71ABC transporters_Homo sapiens_hsa020100.57098646
72Nitrogen metabolism_Homo sapiens_hsa009100.56637022
73Dorso-ventral axis formation_Homo sapiens_hsa043200.55054353
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53247084
75Base excision repair_Homo sapiens_hsa034100.52891112
76RNA degradation_Homo sapiens_hsa030180.52713070
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50640134
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49833826
79Olfactory transduction_Homo sapiens_hsa047400.49221187
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.45373951
81Ether lipid metabolism_Homo sapiens_hsa005650.45158919
82Notch signaling pathway_Homo sapiens_hsa043300.44645293
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.43817225
84Spliceosome_Homo sapiens_hsa030400.43178243
85RNA polymerase_Homo sapiens_hsa030200.43100710
86Caffeine metabolism_Homo sapiens_hsa002320.39881456
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39091169
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38857959
89Circadian rhythm_Homo sapiens_hsa047100.38762276
90Small cell lung cancer_Homo sapiens_hsa052220.38711216
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.38249822
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38192880
93Prostate cancer_Homo sapiens_hsa052150.37441202
94Arachidonic acid metabolism_Homo sapiens_hsa005900.37268741
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36962031
96African trypanosomiasis_Homo sapiens_hsa051430.36619398
97MAPK signaling pathway_Homo sapiens_hsa040100.36049685
98Homologous recombination_Homo sapiens_hsa034400.35674219
99Taste transduction_Homo sapiens_hsa047420.34708482
100Glycerolipid metabolism_Homo sapiens_hsa005610.34129719
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33782610
102Basal transcription factors_Homo sapiens_hsa030220.33508907
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33463295
104Insulin resistance_Homo sapiens_hsa049310.33258227
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32154513
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31361520
107Endocytosis_Homo sapiens_hsa041440.30513377
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29778511
109Oxytocin signaling pathway_Homo sapiens_hsa049210.29768286
110Ras signaling pathway_Homo sapiens_hsa040140.29349434
111Salivary secretion_Homo sapiens_hsa049700.29154873
112Endometrial cancer_Homo sapiens_hsa052130.28870334
113Renin secretion_Homo sapiens_hsa049240.28654938
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.26915079
115Other glycan degradation_Homo sapiens_hsa005110.26584174
116Cholinergic synapse_Homo sapiens_hsa047250.26165201
117mRNA surveillance pathway_Homo sapiens_hsa030150.24315073
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24146556
119VEGF signaling pathway_Homo sapiens_hsa043700.22824312
120Thyroid cancer_Homo sapiens_hsa052160.21693266
121Pathways in cancer_Homo sapiens_hsa052000.21132222
122Non-small cell lung cancer_Homo sapiens_hsa052230.20601084
123Inositol phosphate metabolism_Homo sapiens_hsa005620.19340951
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18827143
125Rap1 signaling pathway_Homo sapiens_hsa040150.18690771
126Adherens junction_Homo sapiens_hsa045200.18356173
127Mismatch repair_Homo sapiens_hsa034300.17817140
128Nucleotide excision repair_Homo sapiens_hsa034200.16253258
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15821931
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.15785392
131MicroRNAs in cancer_Homo sapiens_hsa052060.14447318
132Cell cycle_Homo sapiens_hsa041100.13142380
133DNA replication_Homo sapiens_hsa030300.11582648

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