TXLNA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lactate metabolic process (GO:0006089)6.15157164
2DNA unwinding involved in DNA replication (GO:0006268)5.20896758
3protein localization to kinetochore (GO:0034501)4.90484176
4signal peptide processing (GO:0006465)4.83427190
5positive regulation of protein autophosphorylation (GO:0031954)4.26632887
6nuclear pore complex assembly (GO:0051292)4.13730326
7positive regulation of glycolytic process (GO:0045821)4.08545144
8nuclear pore organization (GO:0006999)4.08271237
9COPII vesicle coating (GO:0048208)4.06250819
10DNA strand elongation involved in DNA replication (GO:0006271)4.00054968
11protein localization to chromosome, centromeric region (GO:0071459)3.91513045
12mitotic nuclear envelope disassembly (GO:0007077)3.85550357
13DNA strand elongation (GO:0022616)3.85520133
14UDP-N-acetylglucosamine metabolic process (GO:0006047)3.83304291
15pteridine-containing compound biosynthetic process (GO:0042559)3.83209999
16formation of translation preinitiation complex (GO:0001731)3.79421683
17IMP biosynthetic process (GO:0006188)3.73184827
18folic acid-containing compound biosynthetic process (GO:0009396)3.71484519
19dosage compensation (GO:0007549)3.68988058
20cullin deneddylation (GO:0010388)3.64969217
21DNA replication initiation (GO:0006270)3.64559702
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.63377737
23respiratory chain complex IV assembly (GO:0008535)3.61754485
24nuclear envelope disassembly (GO:0051081)3.59967061
25membrane disassembly (GO:0030397)3.59967061
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.56027177
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.56027177
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.56027177
29nucleobase biosynthetic process (GO:0046112)3.54235054
30DNA duplex unwinding (GO:0032508)3.45043619
31telomere maintenance via semi-conservative replication (GO:0032201)3.43732446
32DNA replication-dependent nucleosome assembly (GO:0006335)3.43192288
33DNA replication-dependent nucleosome organization (GO:0034723)3.43192288
34DNA geometric change (GO:0032392)3.42096048
35protein K6-linked ubiquitination (GO:0085020)3.40422817
36proteasome assembly (GO:0043248)3.38569543
37regulation of hexokinase activity (GO:1903299)3.38461376
38regulation of glucokinase activity (GO:0033131)3.38461376
39negative regulation of RNA splicing (GO:0033119)3.34538440
40protein deneddylation (GO:0000338)3.31954611
41regulation of translational fidelity (GO:0006450)3.28595228
42IMP metabolic process (GO:0046040)3.28265695
43dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.27768470
44regulation of type B pancreatic cell apoptotic process (GO:2000674)3.27325835
45negative regulation of neurological system process (GO:0031645)3.25990675
46heterochromatin organization (GO:0070828)3.24694317
47maturation of SSU-rRNA (GO:0030490)3.24354110
48pore complex assembly (GO:0046931)3.22997331
49histone H2A acetylation (GO:0043968)3.22805263
50mitotic chromosome condensation (GO:0007076)3.21514794
51DNA replication checkpoint (GO:0000076)3.18117693
52regulation of spindle organization (GO:0090224)3.14434244
53translesion synthesis (GO:0019985)3.14231724
54purine nucleobase biosynthetic process (GO:0009113)3.13280028
55negative regulation of mRNA processing (GO:0050686)3.13147154
56tetrahydrofolate metabolic process (GO:0046653)3.11896451
57negative regulation of acute inflammatory response (GO:0002674)3.11327430
58Golgi transport vesicle coating (GO:0048200)3.11211145
59COPI coating of Golgi vesicle (GO:0048205)3.11211145
60negative regulation of histone methylation (GO:0031061)3.09961292
61mitotic metaphase plate congression (GO:0007080)3.09624958
62mitotic recombination (GO:0006312)3.09483279
63zinc ion transport (GO:0006829)3.08400472
64telomere maintenance via recombination (GO:0000722)3.06157307
65cytochrome complex assembly (GO:0017004)3.06069245
66ketone body metabolic process (GO:1902224)3.05863718
67viral transcription (GO:0019083)3.05719961
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05330408
69water-soluble vitamin biosynthetic process (GO:0042364)3.05325649
70regulation of RNA export from nucleus (GO:0046831)3.03345911
71non-recombinational repair (GO:0000726)3.03305254
72double-strand break repair via nonhomologous end joining (GO:0006303)3.03305254
73keratinocyte development (GO:0003334)3.01675243
74nuclear envelope organization (GO:0006998)2.98357519
75inositol phosphate catabolic process (GO:0071545)2.98232983
76sister chromatid segregation (GO:0000819)2.98175153
77translational termination (GO:0006415)2.97288444
78chromatin assembly (GO:0031497)2.97211635
79branched-chain amino acid catabolic process (GO:0009083)2.96842721
80negative regulation of mRNA metabolic process (GO:1903312)2.96799551
81positive regulation of macroautophagy (GO:0016239)2.96467674
82fatty acid homeostasis (GO:0055089)2.94447219
83protein localization to chromosome (GO:0034502)2.94258994
84L-alpha-amino acid transmembrane transport (GO:1902475)2.94113706
85pre-miRNA processing (GO:0031054)2.92314112
86DNA topological change (GO:0006265)2.91395488
87protein prenylation (GO:0018342)2.90807853
88prenylation (GO:0097354)2.90807853
89ribosomal small subunit assembly (GO:0000028)2.88870001
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88787152
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88787152
92isotype switching (GO:0045190)2.88787152
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87302294
94mitotic sister chromatid cohesion (GO:0007064)2.87234260
95translational initiation (GO:0006413)2.86706385
96chromatin assembly or disassembly (GO:0006333)2.84457202
97metaphase plate congression (GO:0051310)2.83575207
98negative regulation of hormone biosynthetic process (GO:0032353)2.83571598
99regulation of histone H3-K9 methylation (GO:0051570)2.83483113
100positive regulation of chromosome segregation (GO:0051984)2.82090002
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81968998
102mitotic sister chromatid segregation (GO:0000070)2.81966111
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81504695
104DNA double-strand break processing (GO:0000729)2.79977632
105pteridine-containing compound metabolic process (GO:0042558)2.79699303
106cellular response to glucose starvation (GO:0042149)2.79524990
107translational elongation (GO:0006414)2.79332763
108peptidyl-lysine dimethylation (GO:0018027)2.79323316
109regulation of mitotic spindle organization (GO:0060236)2.78671052
110melanin biosynthetic process (GO:0042438)2.78258250
111DNA conformation change (GO:0071103)2.76606145
112mRNA stabilization (GO:0048255)2.76452414
113RNA stabilization (GO:0043489)2.76452414
114nucleotide-sugar biosynthetic process (GO:0009226)2.76233457
115mRNA splicing, via spliceosome (GO:0000398)2.75822915
116RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75822915
117protein maturation by protein folding (GO:0022417)2.75070310
118tRNA aminoacylation for protein translation (GO:0006418)2.74932433
119regulation of protein autophosphorylation (GO:0031952)2.74622116
120telomere maintenance via telomere lengthening (GO:0010833)2.73728415
121regulation of sister chromatid cohesion (GO:0007063)2.73505385
122DNA replication-independent nucleosome organization (GO:0034724)2.73351306
123DNA replication-independent nucleosome assembly (GO:0006336)2.73351306
124amino acid activation (GO:0043038)2.73179783
125tRNA aminoacylation (GO:0043039)2.73179783
126cellular ketone body metabolic process (GO:0046950)2.72385398
127positive regulation of response to extracellular stimulus (GO:0032106)2.71942646
128positive regulation of response to nutrient levels (GO:0032109)2.71942646
129regulation of DNA endoreduplication (GO:0032875)2.71898912
130RNA splicing, via transesterification reactions (GO:0000375)2.71328974
131alternative mRNA splicing, via spliceosome (GO:0000380)2.70514917
1323-UTR-mediated mRNA stabilization (GO:0070935)2.69178272
133base-excision repair (GO:0006284)2.68885486
134ribosome assembly (GO:0042255)2.68305916
135replication fork processing (GO:0031297)2.67063576
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.66946923
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66005974
138female gonad development (GO:0008585)2.65656209
139negative regulation of glycogen metabolic process (GO:0070874)2.65205251
140ER overload response (GO:0006983)2.64385170
141ncRNA 3-end processing (GO:0043628)2.63963800
142spliceosomal tri-snRNP complex assembly (GO:0000244)2.63291411
143snRNA metabolic process (GO:0016073)2.61898636
144response to X-ray (GO:0010165)2.61276707
145nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.60527652
146snRNA processing (GO:0016180)2.59792068
147telomere maintenance via telomerase (GO:0007004)2.59382619
148protein targeting to ER (GO:0045047)2.57628858
149nucleosome disassembly (GO:0006337)2.57327750
150protein-DNA complex disassembly (GO:0032986)2.57327750
151RNA export from nucleus (GO:0006405)2.55382289
152termination of RNA polymerase II transcription (GO:0006369)2.54693530
153cotranslational protein targeting to membrane (GO:0006613)2.54515242
154lipid particle organization (GO:0034389)2.54290489
155ribosomal small subunit biogenesis (GO:0042274)2.52768293
156histone H2A monoubiquitination (GO:0035518)2.52606145
157ATP-dependent chromatin remodeling (GO:0043044)2.52257251
158regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.51660565
159folic acid metabolic process (GO:0046655)2.51302846
160ER to Golgi vesicle-mediated transport (GO:0006888)2.51029644
161sequestering of metal ion (GO:0051238)2.50554168
162nucleotide-excision repair, DNA gap filling (GO:0006297)2.49983585
163mitotic G1 DNA damage checkpoint (GO:0031571)2.49505933
164postreplication repair (GO:0006301)2.49310610
165somatic hypermutation of immunoglobulin genes (GO:0016446)2.48690781
166somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48690781
167negative regulation of gene expression, epigenetic (GO:0045814)2.48611489
168somatic recombination of immunoglobulin gene segments (GO:0016447)2.48257670
169mRNA transport (GO:0051028)2.48121277
170mitochondrial DNA replication (GO:0006264)2.47407714
171negative regulation of activin receptor signaling pathway (GO:0032926)2.46664057
172folic acid-containing compound metabolic process (GO:0006760)2.44520412
173regulation of nuclear cell cycle DNA replication (GO:0033262)2.44508302
174regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.43997325
175positive regulation of hormone biosynthetic process (GO:0046886)2.42995818
176melanin metabolic process (GO:0006582)2.42498691
177DNA strand renaturation (GO:0000733)2.41214901
178peptidyl-histidine modification (GO:0018202)2.41119102
179positive regulation of actin filament depolymerization (GO:0030836)2.40669523
180positive regulation of glycoprotein biosynthetic process (GO:0010560)2.39988046
181regulation of cellular amino acid metabolic process (GO:0006521)2.39823355
182synapsis (GO:0007129)2.36963168
183secondary metabolite biosynthetic process (GO:0044550)2.34569870
184regulation of glucocorticoid metabolic process (GO:0031943)2.32882103
185regulation of centriole replication (GO:0046599)2.32443195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.96662026
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32628404
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.33552694
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24448019
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.14741325
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00654842
7MYC_22102868_ChIP-Seq_BL_Human2.86089070
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.83247255
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79361952
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43720669
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22966055
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19001319
13* XRN2_22483619_ChIP-Seq_HELA_Human2.08870583
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.07119271
15PADI4_21655091_ChIP-ChIP_MCF-7_Human2.06498011
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05020142
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03264623
18VDR_21846776_ChIP-Seq_THP-1_Human1.99813192
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97834092
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95761584
21CIITA_25753668_ChIP-Seq_RAJI_Human1.94177889
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.93761925
23AR_21909140_ChIP-Seq_LNCAP_Human1.92345892
24ZNF274_21170338_ChIP-Seq_K562_Hela1.91442133
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86080249
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.85263110
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.79956347
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.74638920
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70828644
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70023197
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.68573877
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65335242
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61588706
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57856954
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57738378
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57374947
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56033588
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55272322
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54362130
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52458081
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52294907
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.52210981
43FOXP3_21729870_ChIP-Seq_TREG_Human1.51570028
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51283099
45* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51210463
46VDR_23849224_ChIP-Seq_CD4+_Human1.49906559
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49780494
48* GABP_19822575_ChIP-Seq_HepG2_Human1.49453724
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48002574
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.47218005
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43866770
52* KDM5A_27292631_Chip-Seq_BREAST_Human1.43800145
53EWS_26573619_Chip-Seq_HEK293_Human1.42351842
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42102615
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41526860
56DCP1A_22483619_ChIP-Seq_HELA_Human1.40759489
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39920562
58TTF2_22483619_ChIP-Seq_HELA_Human1.39585104
59TFEB_21752829_ChIP-Seq_HELA_Human1.39259474
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38618429
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38491963
62* BRD4_25478319_ChIP-Seq_HGPS_Human1.38178915
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37016507
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36945090
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36923888
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35369645
67TCF7_22412390_ChIP-Seq_EML_Mouse1.35351350
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34602609
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.33551765
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.33467770
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32633106
72FUS_26573619_Chip-Seq_HEK293_Human1.30848824
73* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28591482
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28319827
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27668696
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.27586343
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27007957
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26865499
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26620741
80MYC_18940864_ChIP-ChIP_HL60_Human1.26355805
81SCL_19346495_ChIP-Seq_HPC-7_Human1.26253903
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24016160
83* UTX_26944678_Chip-Seq_JUKART_Human1.23999529
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23747190
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21535248
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20901947
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19434333
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18914949
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18759157
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17860749
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.16868710
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16776001
93MAF_26560356_Chip-Seq_TH1_Human1.16255434
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16240270
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16115691
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15152673
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13842950
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13543682
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13204936
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12237578
101* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12041146
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11930524
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11626357
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11396060
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10725426
106* KDM2B_26808549_Chip-Seq_DND41_Human1.09039560
107* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06565748
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06134580
109P300_19829295_ChIP-Seq_ESCs_Human1.06024839
110CDX2_22108803_ChIP-Seq_LS180_Human1.04885155
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.04842330
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04773906
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04408353
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03286751
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02740035
116NANOG_21062744_ChIP-ChIP_HESCs_Human1.02375383
117ELK1_19687146_ChIP-ChIP_HELA_Human1.01955902
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01810374
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01775590
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00220142
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99095821
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98690043
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98154488
124* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97607845
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97509757
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96558302
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96180826
128* SPI1_23547873_ChIP-Seq_NB4_Human0.95402316
129VDR_24763502_ChIP-Seq_THP-1_Human0.94496997
130* CHD1_26751641_Chip-Seq_LNCaP_Human0.94431113
131* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94211382
132* MYB_26560356_Chip-Seq_TH1_Human0.94101827
133ATF3_27146783_Chip-Seq_COLON_Human0.94006522
134* NCOR1_26117541_ChIP-Seq_K562_Human0.93247955
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.92662659
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92658906
137SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92611017
138MYB_26560356_Chip-Seq_TH2_Human0.92466787
139P300_18555785_Chip-Seq_ESCs_Mouse0.92112960
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.92108415
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91295333
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90860523
143CLOCK_20551151_ChIP-Seq_293T_Human0.90713137
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90370696
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89659269
146* PHF8_20622853_ChIP-Seq_HELA_Human0.88815926
147* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87836020
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87116104
149* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85917910
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.85604194
151WT1_19549856_ChIP-ChIP_CCG9911_Human0.84941716
152STAT3_18555785_Chip-Seq_ESCs_Mouse0.83798898
153GBX2_23144817_ChIP-Seq_PC3_Human0.83600477
154ZFX_18555785_Chip-Seq_ESCs_Mouse0.82767632
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.82721599
156CMYC_18555785_Chip-Seq_ESCs_Mouse0.82502517
157GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82453524
158BCAT_22108803_ChIP-Seq_LS180_Human0.82367474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.00458443
2MP0003693_abnormal_embryo_hatching3.73092441
3MP0003195_calcinosis3.43083004
4MP0003111_abnormal_nucleus_morphology3.25431408
5MP0010094_abnormal_chromosome_stability3.15271202
6MP0005171_absent_coat_pigmentation3.00572628
7MP0003077_abnormal_cell_cycle2.95859451
8MP0004957_abnormal_blastocyst_morpholog2.91334469
9MP0009780_abnormal_chondrocyte_physiolo2.87386939
10MP0000015_abnormal_ear_pigmentation2.84457120
11MP0010352_gastrointestinal_tract_polyps2.81482273
12MP0008057_abnormal_DNA_replication2.73650844
13MP0005408_hypopigmentation2.67885690
14MP0002254_reproductive_system_inflammat2.62631397
15MP0000516_abnormal_urinary_system2.47108836
16MP0005367_renal/urinary_system_phenotyp2.47108836
17MP0002396_abnormal_hematopoietic_system2.42242426
18MP0005174_abnormal_tail_pigmentation2.28557738
19MP0003705_abnormal_hypodermis_morpholog2.21602393
20MP0005075_abnormal_melanosome_morpholog2.20884159
21MP0001730_embryonic_growth_arrest2.19691271
22MP0002837_dystrophic_cardiac_calcinosis2.15490867
23MP0008007_abnormal_cellular_replicative2.14817125
24MP0005379_endocrine/exocrine_gland_phen2.03789452
25MP0005076_abnormal_cell_differentiation2.03299832
26MP0000569_abnormal_digit_pigmentation2.01117356
27MP0000350_abnormal_cell_proliferation1.99024189
28MP0004808_abnormal_hematopoietic_stem1.86915885
29MP0010307_abnormal_tumor_latency1.84723899
30MP0006054_spinal_hemorrhage1.84185499
31MP0003123_paternal_imprinting1.79216668
32MP0002909_abnormal_adrenal_gland1.79077314
33MP0008932_abnormal_embryonic_tissue1.77335469
34MP0000537_abnormal_urethra_morphology1.71444716
35MP0008058_abnormal_DNA_repair1.70870975
36MP0002102_abnormal_ear_morphology1.70105563
37MP0009278_abnormal_bone_marrow1.68565443
38MP0002163_abnormal_gland_morphology1.66888244
39MP0001661_extended_life_span1.64337421
40MP0002090_abnormal_vision1.62922512
41MP0001672_abnormal_embryogenesis/_devel1.61881360
42MP0005380_embryogenesis_phenotype1.61881360
43MP0001697_abnormal_embryo_size1.61727144
44MP0004197_abnormal_fetal_growth/weight/1.61384697
45MP0002084_abnormal_developmental_patter1.60348947
46MP0003806_abnormal_nucleotide_metabolis1.59296560
47MP0010030_abnormal_orbit_morphology1.57139379
48MP0003984_embryonic_growth_retardation1.53421549
49MP0000490_abnormal_crypts_of1.53200502
50MP0002085_abnormal_embryonic_tissue1.52405571
51MP0002088_abnormal_embryonic_growth/wei1.52286866
52MP0002080_prenatal_lethality1.51290303
53MP0002877_abnormal_melanocyte_morpholog1.47650483
54MP0001849_ear_inflammation1.46004614
55MP0002876_abnormal_thyroid_physiology1.44550341
56MP0002086_abnormal_extraembryonic_tissu1.43736226
57MP0000613_abnormal_salivary_gland1.43715717
58MP0005257_abnormal_intraocular_pressure1.42641543
59MP0001944_abnormal_pancreas_morphology1.40216841
60MP0003950_abnormal_plasma_membrane1.40157319
61MP0003566_abnormal_cell_adhesion1.39547232
62MP0009697_abnormal_copulation1.37710327
63MP0003283_abnormal_digestive_organ1.36933460
64MP0003172_abnormal_lysosome_physiology1.35963314
65MP0002095_abnormal_skin_pigmentation1.35371068
66MP0006072_abnormal_retinal_apoptosis1.32541065
67MP0003763_abnormal_thymus_physiology1.31287335
68MP0000013_abnormal_adipose_tissue1.28693816
69MP0003567_abnormal_fetal_cardiomyocyte1.27886987
70MP0000703_abnormal_thymus_morphology1.25631043
71MP0002019_abnormal_tumor_incidence1.25584712
72MP0000428_abnormal_craniofacial_morphol1.24629281
73MP0000313_abnormal_cell_death1.23550963
74MP0003136_yellow_coat_color1.23142736
75MP0003718_maternal_effect1.22983569
76MP0005397_hematopoietic_system_phenotyp1.20995034
77MP0001545_abnormal_hematopoietic_system1.20995034
78MP0008438_abnormal_cutaneous_collagen1.18930345
79MP0000733_abnormal_muscle_development1.17553111
80MP0003300_gastrointestinal_ulcer1.15971705
81MP0005023_abnormal_wound_healing1.13807424
82MP0003121_genomic_imprinting1.13494124
83MP0009053_abnormal_anal_canal1.12953372
84MP0005187_abnormal_penis_morphology1.12665901
85MP0008961_abnormal_basal_metabolism1.12354824
86MP0001293_anophthalmia1.11902911
87MP0003786_premature_aging1.11400595
88MP0002693_abnormal_pancreas_physiology1.09663238
89MP0003941_abnormal_skin_development1.08670044
90MP0003890_abnormal_embryonic-extraembry1.08655323
91MP0002398_abnormal_bone_marrow1.06527598
92MP0003186_abnormal_redox_activity1.04824510
93MP0000465_gastrointestinal_hemorrhage1.04740542
94MP0009333_abnormal_splenocyte_physiolog1.02818048
95MP0009672_abnormal_birth_weight1.01544597
96MP0002075_abnormal_coat/hair_pigmentati1.00200496
97MP0005395_other_phenotype0.99920035
98MP0005220_abnormal_exocrine_pancreas0.99630119
99MP0002177_abnormal_outer_ear0.99237731
100MP0005253_abnormal_eye_physiology0.98212176
101MP0001915_intracranial_hemorrhage0.98075777
102MP0001756_abnormal_urination0.98000093
103MP0003119_abnormal_digestive_system0.97739422
104MP0002722_abnormal_immune_system0.97694208
105MP0006036_abnormal_mitochondrial_physio0.97405047
106MP0000427_abnormal_hair_cycle0.96747716
107MP0005332_abnormal_amino_acid0.96547596
108MP0002092_abnormal_eye_morphology0.95932315
109MP0000538_abnormal_urinary_bladder0.95440073
110MP0004264_abnormal_extraembryonic_tissu0.95325373
111MP0000358_abnormal_cell_content/0.91824136
112MP0003115_abnormal_respiratory_system0.91119723
113MP0002111_abnormal_tail_morphology0.91069810
114MP0010234_abnormal_vibrissa_follicle0.90931751
115MP0001324_abnormal_eye_pigmentation0.90651471
116MP0002168_other_aberrant_phenotype0.90348786
117MP0005645_abnormal_hypothalamus_physiol0.89352389
118MP0001186_pigmentation_phenotype0.89203531
119MP0000689_abnormal_spleen_morphology0.89017190
120MP0000477_abnormal_intestine_morphology0.84541111
121MP0002925_abnormal_cardiovascular_devel0.83506029
122MP0003935_abnormal_craniofacial_develop0.83431721
123MP0003122_maternal_imprinting0.82812322
124MP0004185_abnormal_adipocyte_glucose0.81135062
125MP0000647_abnormal_sebaceous_gland0.80809774
126MP0005621_abnormal_cell_physiology0.80720104
127MP0009703_decreased_birth_body0.79621995
128MP0002429_abnormal_blood_cell0.79502710
129MP0008877_abnormal_DNA_methylation0.79404351
130MP0004272_abnormal_basement_membrane0.79218103
131MP0000639_abnormal_adrenal_gland0.78989312
132MP0000858_altered_metastatic_potential0.78866797
133MP0002166_altered_tumor_susceptibility0.77767396
134MP0002932_abnormal_joint_morphology0.77164336
135MP0003303_peritoneal_inflammation0.77044556
136MP0010678_abnormal_skin_adnexa0.76032950
137MP0004381_abnormal_hair_follicle0.74789513
138MP0005384_cellular_phenotype0.73404418
139MP0002234_abnormal_pharynx_morphology0.73245378
140MP0002295_abnormal_pulmonary_circulatio0.72806378
141MP0003943_abnormal_hepatobiliary_system0.71955711
142MP0003868_abnormal_feces_composition0.71685558
143MP0000685_abnormal_immune_system0.70512864
144MP0003091_abnormal_cell_migration0.70393875
145MP0002697_abnormal_eye_size0.69828055
146MP0002160_abnormal_reproductive_system0.69341188
147MP0003279_aneurysm0.69227361
148MP0001243_abnormal_dermal_layer0.68449414
149MP0000716_abnormal_immune_system0.68392373
150MP0002653_abnormal_ependyma_morphology0.68233590
151MP0000383_abnormal_hair_follicle0.67516142
152MP0001929_abnormal_gametogenesis0.67114636
153MP0005508_abnormal_skeleton_morphology0.66433969
154MP0000377_abnormal_hair_follicle0.65978339
155MP0003937_abnormal_limbs/digits/tail_de0.65842853
156MP0000767_abnormal_smooth_muscle0.65525719
157MP0000371_diluted_coat_color0.65348255
158MP0002938_white_spotting0.64690693
159MP0002751_abnormal_autonomic_nervous0.64226144
160MP0000432_abnormal_head_morphology0.63410912
161MP0005248_abnormal_Harderian_gland0.62840453
162MP0000003_abnormal_adipose_tissue0.61871226
163MP0002060_abnormal_skin_morphology0.61709237
164MP0005623_abnormal_meninges_morphology0.61385403
165MP0006035_abnormal_mitochondrial_morpho0.59864934
166MP0003787_abnormal_imprinting0.58484237
167MP0002078_abnormal_glucose_homeostasis0.57927406
168MP0005636_abnormal_mineral_homeostasis0.56727980
169MP0000653_abnormal_sex_gland0.56254247

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.71610967
2Hyperinsulinemic hypoglycemia (HP:0000825)4.68822368
3Cutaneous melanoma (HP:0012056)4.23177343
4Hypoglycemic coma (HP:0001325)4.00949513
5Neoplasm of the adrenal cortex (HP:0100641)3.99985277
6Abnormality of the pancreatic islet cells (HP:0006476)3.84700738
7Abnormality of endocrine pancreas physiology (HP:0012093)3.84700738
8Ketoacidosis (HP:0001993)3.78201358
9Symptomatic seizures (HP:0011145)3.69491713
10Hypothermia (HP:0002045)3.48560230
11Abnormality of methionine metabolism (HP:0010901)3.42045084
12Hamartoma of the eye (HP:0010568)3.37447841
13Hyperglycemia (HP:0003074)3.32702782
14Selective tooth agenesis (HP:0001592)3.24938464
15Patchy hypopigmentation of hair (HP:0011365)3.20870359
16Ependymoma (HP:0002888)3.13068538
17Hyperacusis (HP:0010780)3.11261699
18Neoplasm of the adrenal gland (HP:0100631)3.10064773
19Albinism (HP:0001022)3.06867631
20Abnormality of the metopic suture (HP:0005556)2.97453780
21White forelock (HP:0002211)2.88185024
22Cerebral aneurysm (HP:0004944)2.87365535
23Pancreatic islet-cell hyperplasia (HP:0004510)2.85946448
24Protrusio acetabuli (HP:0003179)2.84974765
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74596180
26Short 4th metacarpal (HP:0010044)2.74596180
27Medulloblastoma (HP:0002885)2.72970201
28Reticulocytopenia (HP:0001896)2.70854631
29Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68872566
30Hypoplasia of the fovea (HP:0007750)2.67596343
31Aplasia/Hypoplasia of the fovea (HP:0008060)2.67596343
32Enlarged penis (HP:0000040)2.66869481
33Renal duplication (HP:0000075)2.64865691
34Hypobetalipoproteinemia (HP:0003563)2.63802683
35Tongue fasciculations (HP:0001308)2.63256738
36Hypokinesia (HP:0002375)2.61457151
37Colon cancer (HP:0003003)2.58753625
38Proximal placement of thumb (HP:0009623)2.50763525
39Increased nuchal translucency (HP:0010880)2.48805931
40Methylmalonic acidemia (HP:0002912)2.48401552
41Conjunctival hamartoma (HP:0100780)2.47419806
42Type I transferrin isoform profile (HP:0003642)2.47079691
43Deviation of the thumb (HP:0009603)2.46374707
44Large for gestational age (HP:0001520)2.43486157
45Urethral obstruction (HP:0000796)2.41140193
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39797668
47Abnormal protein N-linked glycosylation (HP:0012347)2.39797668
48Abnormal protein glycosylation (HP:0012346)2.39797668
49Abnormal glycosylation (HP:0012345)2.39797668
50Ankle contracture (HP:0006466)2.39131441
51Shallow orbits (HP:0000586)2.37848716
52Intestinal atresia (HP:0011100)2.37476639
53Bowel diverticulosis (HP:0005222)2.37269103
54Missing ribs (HP:0000921)2.35679910
55Abnormality of cells of the erythroid lineage (HP:0012130)2.33360534
56Asymmetry of the thorax (HP:0001555)2.32441138
57High pitched voice (HP:0001620)2.31690686
58Abnormality of glycolysis (HP:0004366)2.31612116
59Abnormality of the labia minora (HP:0012880)2.31289162
6011 pairs of ribs (HP:0000878)2.30180018
61Long eyelashes (HP:0000527)2.28415805
62Abnormality of the fingertips (HP:0001211)2.28099891
63Abnormality of the fovea (HP:0000493)2.26156263
64Aplasia/Hypoplasia of the macula (HP:0008059)2.24751163
65Birth length less than 3rd percentile (HP:0003561)2.24720343
66Abnormality of vitamin B metabolism (HP:0004340)2.23546651
67Ketosis (HP:0001946)2.21654741
68Abnormal number of erythroid precursors (HP:0012131)2.20703980
69Sensory axonal neuropathy (HP:0003390)2.19720832
70Cholecystitis (HP:0001082)2.17115937
71Abnormal gallbladder physiology (HP:0012438)2.17115937
72Overriding aorta (HP:0002623)2.16932520
73Prominent nose (HP:0000448)2.16577019
74Thrombocytosis (HP:0001894)2.16496156
75Abnormality of the calcaneus (HP:0008364)2.15284959
76Basal cell carcinoma (HP:0002671)2.13316420
77Overlapping toe (HP:0001845)2.12522780
78Abnormality of the 4th metacarpal (HP:0010012)2.11870546
79Hematochezia (HP:0002573)2.11650649
80Ulnar bowing (HP:0003031)2.10972152
81Slender long bone (HP:0003100)2.10279644
82Elfin facies (HP:0004428)2.07973230
83Patellar aplasia (HP:0006443)2.06435157
84Methylmalonic aciduria (HP:0012120)2.06245497
85Delayed gross motor development (HP:0002194)2.05584981
86Renovascular hypertension (HP:0100817)2.05140555
87Degeneration of anterior horn cells (HP:0002398)2.04422120
88Abnormality of the anterior horn cell (HP:0006802)2.04422120
89Heterochromia iridis (HP:0001100)2.03814302
90Aplasia/Hypoplasia affecting the retina (HP:0008061)2.02946456
91Bladder diverticulum (HP:0000015)2.02698232
92Premature rupture of membranes (HP:0001788)2.01719097
93Meningioma (HP:0002858)1.99857199
94Bilateral sensorineural hearing impairment (HP:0008619)1.98505836
95Astrocytoma (HP:0009592)1.98458577
96Abnormality of the astrocytes (HP:0100707)1.98458577
97Neoplasm of the pancreas (HP:0002894)1.98017714
98Secondary amenorrhea (HP:0000869)1.97660424
99Muscle fibrillation (HP:0010546)1.97265651
100Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96806747
101Short 1st metacarpal (HP:0010034)1.96806747
102Squamous cell carcinoma (HP:0002860)1.95489541
103Increased density of long bones (HP:0006392)1.95435257
104Abnormality of sulfur amino acid metabolism (HP:0004339)1.94799230
105Aplasia/Hypoplasia of the patella (HP:0006498)1.94461630
106Generalized hypopigmentation (HP:0007513)1.94397313
107Skin tags (HP:0010609)1.93870246
108Hypolipoproteinemia (HP:0010981)1.93378725
109Vascular calcification (HP:0004934)1.92526267
110Abnormal number of incisors (HP:0011064)1.92356519
111Posterior subcapsular cataract (HP:0007787)1.90530712
112Cardiovascular calcification (HP:0011915)1.88681301
113Unilateral renal agenesis (HP:0000122)1.88588178
114Gaze-evoked nystagmus (HP:0000640)1.88539178
115Trismus (HP:0000211)1.88377715
116Multiple enchondromatosis (HP:0005701)1.87512422
117Flat cornea (HP:0007720)1.87288820
118Aqueductal stenosis (HP:0002410)1.86719004
119Progressive macrocephaly (HP:0004481)1.85829089
120Melanoma (HP:0002861)1.84771555
121Disproportionate short-trunk short stature (HP:0003521)1.84125139
122Aplastic anemia (HP:0001915)1.83958267
123Broad palm (HP:0001169)1.83445736
124Preauricular skin tag (HP:0000384)1.83123981
125Megalocornea (HP:0000485)1.81450937
126Glioma (HP:0009733)1.81009514
127Neoplasm of the oral cavity (HP:0100649)1.80976413
128Volvulus (HP:0002580)1.80767133
129Bicuspid aortic valve (HP:0001647)1.80662507
130Angiofibromas (HP:0010615)1.80126970
131Adenoma sebaceum (HP:0009720)1.80126970
132Increased CSF protein (HP:0002922)1.80115326
133Hypomagnesemia (HP:0002917)1.79795117
134Breast carcinoma (HP:0003002)1.79670397
135Reduced antithrombin III activity (HP:0001976)1.79659886
136Neoplasm of striated muscle (HP:0009728)1.79071567
137Abnormality of the peritoneum (HP:0002585)1.79061729
138Muscular hypotonia of the trunk (HP:0008936)1.78980237
139Insomnia (HP:0100785)1.78823484
140Iris hypopigmentation (HP:0007730)1.78812080
141Atresia of the external auditory canal (HP:0000413)1.78689760
142Macroorchidism (HP:0000053)1.78311964
143Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77588647
144Ocular albinism (HP:0001107)1.77337996
145Type I diabetes mellitus (HP:0100651)1.77147131
146Hepatic necrosis (HP:0002605)1.76648139
147Downturned corners of mouth (HP:0002714)1.76072133
148Hallux valgus (HP:0001822)1.75917500
149Cervical subluxation (HP:0003308)1.75576527
150Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73812033
151Deviation of the hallux (HP:0010051)1.72173179
152Myelodysplasia (HP:0002863)1.70496867
153Chromsome breakage (HP:0040012)1.70224832
154Rhabdomyosarcoma (HP:0002859)1.69928771
155Intestinal polyposis (HP:0200008)1.69341508
156Abnormality of vitamin metabolism (HP:0100508)1.69303151
157Genu recurvatum (HP:0002816)1.68860271
158Blue irides (HP:0000635)1.68535416
159Amaurosis fugax (HP:0100576)1.67923886
160Broad thumb (HP:0011304)1.67838186
161Entropion (HP:0000621)1.67034438
162Poikiloderma (HP:0001029)1.64871755
163Carpal bone hypoplasia (HP:0001498)1.64739012
164Short 5th finger (HP:0009237)1.63963155
165Breast hypoplasia (HP:0003187)1.63523499
166Pointed chin (HP:0000307)1.60702957
167Broad face (HP:0000283)1.60518932
168Severe short stature (HP:0003510)1.60329783
169Thoracolumbar scoliosis (HP:0002944)1.59348720
170Ectopic kidney (HP:0000086)1.59206646
171Rib fusion (HP:0000902)1.58584849
172Dilatation of the ascending aorta (HP:0005111)1.57522514
173Hand muscle atrophy (HP:0009130)1.57355357
174Aortic aneurysm (HP:0004942)1.57157507
175Radial bowing (HP:0002986)1.56219674
176Gastrointestinal carcinoma (HP:0002672)1.56161969
177Malignant gastrointestinal tract tumors (HP:0006749)1.56161969
178Mitral valve prolapse (HP:0001634)1.55348026
179Broad phalanges of the hand (HP:0009768)1.55319404
180Acute lymphatic leukemia (HP:0006721)1.55072324
181Pallor (HP:0000980)1.53366551
182Cellulitis (HP:0100658)1.52539093
183Facial hemangioma (HP:0000329)1.51517292
184Abnormality of chromosome stability (HP:0003220)1.51153150
185Cutis marmorata (HP:0000965)1.51096210
186Prominent metopic ridge (HP:0005487)1.46433730
187Bowed forearm bones (HP:0003956)1.46348032
188Bowing of the arm (HP:0006488)1.46348032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.79774479
2TRIM283.84321488
3EEF2K3.69887798
4CDC73.20237013
5CDK122.84295510
6PKN22.79994332
7MAP3K102.78879842
8TRIB32.77807030
9NEK22.52811485
10WEE12.48942661
11MST42.38327892
12PASK2.30522267
13ERN12.30004033
14SCYL22.27567072
15WNK32.20053409
16MKNK22.12820895
17BUB11.99017068
18FER1.97053038
19PLK21.88805307
20PDK21.81815726
21ERBB31.77527668
22MAP4K11.74159299
23PAK31.71382755
24PBK1.70205892
25RPS6KB21.68767355
26TGFBR11.66362845
27STK101.65707863
28FLT31.60788332
29PDGFRA1.58495301
30SIK31.57440577
31NUAK11.55806138
32DYRK31.51528945
33PTK61.49542504
34TSSK61.48855177
35BRSK21.47190864
36CDK71.44200730
37ATR1.43712745
38SRPK11.42234522
39GRK11.41594418
40CSNK1G11.37331589
41LRRK21.36236915
42AKT31.36159135
43CDK41.35048259
44TTK1.34948530
45VRK21.34758640
46RIPK11.32133333
47PAK41.30501508
48BRD41.28430931
49MKNK11.28162983
50MAP3K81.26971444
51ACVR1B1.26725254
52TESK21.20616172
53MTOR1.20378722
54RPS6KA41.17048239
55ZAK1.15773944
56STK38L1.15215722
57AURKB1.15143453
58MAP2K31.14317323
59PLK11.13897934
60NLK1.12586564
61CSNK1G31.11707724
62FGFR41.10749819
63MAP4K21.09210362
64BCR1.08859461
65TTN1.06973477
66TRPM71.02638663
67CHEK11.01650868
68ALK1.01527178
69TNIK1.01111162
70PNCK1.00120638
71ZAP700.97811347
72ICK0.96956581
73NME20.95453226
74CDK60.94915969
75TAF10.94853570
76PAK20.92966409
77BTK0.92754355
78PRKCI0.92405001
79JAK30.91563463
80BMPR1B0.89955808
81CSNK1G20.85758919
82NEK90.84806017
83MAPKAPK30.84695971
84PTK20.83603690
85STK240.83359051
86PRKD30.79626102
87BRSK10.79504593
88EIF2AK20.78276868
89CHEK20.77758858
90CSF1R0.77144412
91TLK10.76566584
92PIM10.76399391
93CSNK1A1L0.75986078
94CDK20.74556045
95STK40.74468765
96DYRK1B0.67540005
97ITK0.66309123
98MELK0.65210227
99KIT0.64177264
100SIK10.63968026
101ATM0.62754862
102NEK10.61715459
103AURKA0.61639085
104DDR20.60188634
105DAPK10.59947837
106ADRBK20.59484156
107GSK3A0.59256836
108FGFR10.57746044
109CLK10.55423044
110MAP3K20.54994328
111PDGFRB0.53941818
112HIPK20.53714177
113PRKCE0.53043020
114PLK30.52623421
115TYRO30.51278746
116PIM20.51196626
117SMG10.50849087
118PAK10.50825758
119PRKAA20.50087434
120CDK10.49527172
121TYK20.49425693
122CCNB10.49136977
123EIF2AK30.49002885
124INSRR0.48929736
125FGFR20.48204128
126EPHA20.48132488
127PLK40.48034605
128TGFBR20.47673755
129LATS10.47572928
130VRK10.46672510
131ERBB40.45848794
132STK30.44883638
133PAK60.44261364
134CHUK0.43706654
135ILK0.43139903
136PRKAA10.42926705
137EIF2AK10.42157944
138PTK2B0.42152047
139AKT20.40382489
140NEK60.39984579
141CAMK1D0.39960057
142MAP2K20.39065671
143PRKD20.37850694
144MATK0.36340906
145GRK60.36047847
146MAPK110.36010877
147BMX0.35673732
148PHKG10.35548863
149PHKG20.35548863
150CSNK2A20.34549132
151LIMK10.34179497
152CAMK1G0.33694030
153PRKDC0.33603085
154FGFR30.33137170
155MAP3K30.32750708
156MYLK0.29421592
157MAP3K120.28953492
158CSNK1A10.26811033

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.15599934
2Vitamin B6 metabolism_Homo sapiens_hsa007503.70091157
3Mismatch repair_Homo sapiens_hsa034303.17994641
4Spliceosome_Homo sapiens_hsa030402.98725179
5Base excision repair_Homo sapiens_hsa034102.83560432
6RNA transport_Homo sapiens_hsa030132.70281523
7Cell cycle_Homo sapiens_hsa041102.67419703
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45238125
9One carbon pool by folate_Homo sapiens_hsa006702.35636001
10Fatty acid elongation_Homo sapiens_hsa000622.19287924
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15791968
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11819107
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11713523
14Homologous recombination_Homo sapiens_hsa034402.07738245
15Ribosome_Homo sapiens_hsa030101.94883484
16Nucleotide excision repair_Homo sapiens_hsa034201.93516165
17Propanoate metabolism_Homo sapiens_hsa006401.88692300
18Non-homologous end-joining_Homo sapiens_hsa034501.88423099
19Sulfur metabolism_Homo sapiens_hsa009201.86036615
20mRNA surveillance pathway_Homo sapiens_hsa030151.75275602
21p53 signaling pathway_Homo sapiens_hsa041151.65197545
22Butanoate metabolism_Homo sapiens_hsa006501.63818800
23RNA polymerase_Homo sapiens_hsa030201.58454689
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56867430
25Chronic myeloid leukemia_Homo sapiens_hsa052201.51803074
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46950105
27Selenocompound metabolism_Homo sapiens_hsa004501.44007808
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43846693
29Pyrimidine metabolism_Homo sapiens_hsa002401.43232050
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.42470105
31Fanconi anemia pathway_Homo sapiens_hsa034601.41313570
32Viral carcinogenesis_Homo sapiens_hsa052031.40621353
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40313295
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37160727
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36481589
36Notch signaling pathway_Homo sapiens_hsa043301.35539812
37RNA degradation_Homo sapiens_hsa030181.34939604
38Small cell lung cancer_Homo sapiens_hsa052221.31548953
39MicroRNAs in cancer_Homo sapiens_hsa052061.28835807
40Antigen processing and presentation_Homo sapiens_hsa046121.21934782
41HTLV-I infection_Homo sapiens_hsa051661.19394115
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19074139
43Epstein-Barr virus infection_Homo sapiens_hsa051691.17507411
44Systemic lupus erythematosus_Homo sapiens_hsa053221.16725693
45Regulation of autophagy_Homo sapiens_hsa041401.15939888
46Steroid biosynthesis_Homo sapiens_hsa001001.11914983
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10382989
48Fatty acid metabolism_Homo sapiens_hsa012121.09801272
49Herpes simplex infection_Homo sapiens_hsa051681.09476412
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07792735
51Sphingolipid metabolism_Homo sapiens_hsa006001.06477848
52Pyruvate metabolism_Homo sapiens_hsa006201.05886211
53Basal cell carcinoma_Homo sapiens_hsa052171.05194570
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03727782
55Lysine degradation_Homo sapiens_hsa003101.03380993
56Thyroid cancer_Homo sapiens_hsa052160.99392624
57Glutathione metabolism_Homo sapiens_hsa004800.99357798
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98938479
59N-Glycan biosynthesis_Homo sapiens_hsa005100.98780933
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95916279
61Colorectal cancer_Homo sapiens_hsa052100.95305396
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95013372
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.93283537
64Peroxisome_Homo sapiens_hsa041460.93157455
65Acute myeloid leukemia_Homo sapiens_hsa052210.91577378
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90660678
67Bladder cancer_Homo sapiens_hsa052190.90590869
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.90564279
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89456081
70mTOR signaling pathway_Homo sapiens_hsa041500.87099216
71Carbon metabolism_Homo sapiens_hsa012000.86621198
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85144757
73Hippo signaling pathway_Homo sapiens_hsa043900.83822119
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.83229302
75Basal transcription factors_Homo sapiens_hsa030220.82854867
76Hepatitis B_Homo sapiens_hsa051610.82564393
77Apoptosis_Homo sapiens_hsa042100.82118388
78Pancreatic cancer_Homo sapiens_hsa052120.81464442
79Proteoglycans in cancer_Homo sapiens_hsa052050.80315777
80beta-Alanine metabolism_Homo sapiens_hsa004100.80276723
81Non-small cell lung cancer_Homo sapiens_hsa052230.80064862
82Primary immunodeficiency_Homo sapiens_hsa053400.78409769
83Fatty acid degradation_Homo sapiens_hsa000710.77371982
84Fructose and mannose metabolism_Homo sapiens_hsa000510.74766438
85Tryptophan metabolism_Homo sapiens_hsa003800.74745917
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73727520
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.73638895
88B cell receptor signaling pathway_Homo sapiens_hsa046620.73289624
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.72335458
90Shigellosis_Homo sapiens_hsa051310.71562837
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.71484077
92Circadian rhythm_Homo sapiens_hsa047100.69564406
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69512599
94Proteasome_Homo sapiens_hsa030500.68612602
95Vibrio cholerae infection_Homo sapiens_hsa051100.68202519
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67432791
97Adherens junction_Homo sapiens_hsa045200.67361379
98TGF-beta signaling pathway_Homo sapiens_hsa043500.67304076
99Collecting duct acid secretion_Homo sapiens_hsa049660.66527542
100Legionellosis_Homo sapiens_hsa051340.66497279
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.66227729
102Measles_Homo sapiens_hsa051620.66028098
103Pathways in cancer_Homo sapiens_hsa052000.65198877
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64711934
105Hedgehog signaling pathway_Homo sapiens_hsa043400.63548845
106Oocyte meiosis_Homo sapiens_hsa041140.63442503
107Biosynthesis of amino acids_Homo sapiens_hsa012300.63075383
108Metabolic pathways_Homo sapiens_hsa011000.62418960
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61112924
110Insulin secretion_Homo sapiens_hsa049110.59437635
111Prostate cancer_Homo sapiens_hsa052150.59318477
112Focal adhesion_Homo sapiens_hsa045100.59063817
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58944440
114Other glycan degradation_Homo sapiens_hsa005110.56966628
115Endometrial cancer_Homo sapiens_hsa052130.56957698
116Toxoplasmosis_Homo sapiens_hsa051450.56090194
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55656480
118Purine metabolism_Homo sapiens_hsa002300.54769021
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.53746925
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53562294
121Pentose phosphate pathway_Homo sapiens_hsa000300.53430107
122Viral myocarditis_Homo sapiens_hsa054160.52293941
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51681812
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51290817
125Folate biosynthesis_Homo sapiens_hsa007900.50090919
126Galactose metabolism_Homo sapiens_hsa000520.49640395
127Leishmaniasis_Homo sapiens_hsa051400.49546692
128Protein export_Homo sapiens_hsa030600.48981631
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48951983
130ECM-receptor interaction_Homo sapiens_hsa045120.48629584
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.47896139
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47677530
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47230404
134HIF-1 signaling pathway_Homo sapiens_hsa040660.46943791
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46052692
136Sulfur relay system_Homo sapiens_hsa041220.45901168
137Alcoholism_Homo sapiens_hsa050340.44909449
138VEGF signaling pathway_Homo sapiens_hsa043700.44298746
139Platelet activation_Homo sapiens_hsa046110.44088228
140T cell receptor signaling pathway_Homo sapiens_hsa046600.44042235
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.43434119
142Caffeine metabolism_Homo sapiens_hsa002320.42423160
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41879716
144Influenza A_Homo sapiens_hsa051640.41581556
145Insulin resistance_Homo sapiens_hsa049310.40483165
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38314588
147Osteoclast differentiation_Homo sapiens_hsa043800.37824704
148AMPK signaling pathway_Homo sapiens_hsa041520.37672961
149Lysosome_Homo sapiens_hsa041420.36169632
150Ether lipid metabolism_Homo sapiens_hsa005650.34136272
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32319623
152Type I diabetes mellitus_Homo sapiens_hsa049400.32158334
153Mineral absorption_Homo sapiens_hsa049780.31687667
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31306531
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29441972
156Glucagon signaling pathway_Homo sapiens_hsa049220.28988634
157Arginine and proline metabolism_Homo sapiens_hsa003300.28373085
158Phototransduction_Homo sapiens_hsa047440.26838163
159Melanoma_Homo sapiens_hsa052180.24821436
160Tight junction_Homo sapiens_hsa045300.24364739

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