

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sarcomere organization (GO:0045214) | 8.93589790 |
| 2 | actin-myosin filament sliding (GO:0033275) | 8.14261296 |
| 3 | muscle filament sliding (GO:0030049) | 8.14261296 |
| 4 | cardiac myofibril assembly (GO:0055003) | 7.89947954 |
| 5 | myofibril assembly (GO:0030239) | 7.65609376 |
| 6 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 7.60347578 |
| 7 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.55966794 |
| 8 | regulation of skeletal muscle contraction (GO:0014819) | 7.35090079 |
| 9 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 7.09317607 |
| 10 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 6.80840656 |
| 11 | actin-mediated cell contraction (GO:0070252) | 6.72876015 |
| 12 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.70634252 |
| 13 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 6.49795605 |
| 14 | cardiac muscle contraction (GO:0060048) | 6.44642089 |
| 15 | tricarboxylic acid cycle (GO:0006099) | 6.41199642 |
| 16 | regulation of relaxation of muscle (GO:1901077) | 6.38143500 |
| 17 | plasma membrane repair (GO:0001778) | 6.33830542 |
| 18 | regulation of actin filament-based movement (GO:1903115) | 5.95725135 |
| 19 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.91832689 |
| 20 | regulation of cell communication by electrical coupling (GO:0010649) | 5.87006172 |
| 21 | cardiac muscle cell development (GO:0055013) | 5.82204155 |
| 22 | skeletal muscle fiber development (GO:0048741) | 5.81145657 |
| 23 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.80862988 |
| 24 | carnitine shuttle (GO:0006853) | 5.75007895 |
| 25 | striated muscle contraction (GO:0006941) | 5.73079092 |
| 26 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.71373041 |
| 27 | actomyosin structure organization (GO:0031032) | 5.66537538 |
| 28 | cardiac cell development (GO:0055006) | 5.45999038 |
| 29 | myotube cell development (GO:0014904) | 5.41415079 |
| 30 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 5.39123498 |
| 31 | cardiac muscle hypertrophy (GO:0003300) | 5.23622020 |
| 32 | skeletal muscle contraction (GO:0003009) | 5.13882738 |
| 33 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 5.13695038 |
| 34 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.12357678 |
| 35 | regulation of sarcomere organization (GO:0060297) | 5.11101320 |
| 36 | ventricular cardiac muscle cell action potential (GO:0086005) | 5.10823745 |
| 37 | cardiac muscle tissue morphogenesis (GO:0055008) | 5.09946618 |
| 38 | striated muscle hypertrophy (GO:0014897) | 5.04641850 |
| 39 | actin filament-based movement (GO:0030048) | 5.04532297 |
| 40 | fatty acid transmembrane transport (GO:1902001) | 5.00013915 |
| 41 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.96752631 |
| 42 | adult heart development (GO:0007512) | 4.90925066 |
| 43 | regulation of coenzyme metabolic process (GO:0051196) | 4.89572622 |
| 44 | regulation of cofactor metabolic process (GO:0051193) | 4.89572622 |
| 45 | regulation of striated muscle contraction (GO:0006942) | 4.88579110 |
| 46 | heart process (GO:0003015) | 4.87535763 |
| 47 | heart contraction (GO:0060047) | 4.87535763 |
| 48 | muscle fiber development (GO:0048747) | 4.74933683 |
| 49 | creatine metabolic process (GO:0006600) | 4.74579499 |
| 50 | muscle tissue morphogenesis (GO:0060415) | 4.65596190 |
| 51 | skeletal muscle tissue development (GO:0007519) | 4.63924650 |
| 52 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 4.56967821 |
| 53 | glucan biosynthetic process (GO:0009250) | 4.55274924 |
| 54 | glycogen biosynthetic process (GO:0005978) | 4.55274924 |
| 55 | heart trabecula formation (GO:0060347) | 4.54841770 |
| 56 | skeletal muscle adaptation (GO:0043501) | 4.51750681 |
| 57 | muscle hypertrophy (GO:0014896) | 4.47638804 |
| 58 | regulation of membrane repolarization (GO:0060306) | 4.42885848 |
| 59 | cellular polysaccharide catabolic process (GO:0044247) | 4.42460154 |
| 60 | skeletal muscle tissue regeneration (GO:0043403) | 4.29306019 |
| 61 | carnitine transmembrane transport (GO:1902603) | 4.26067237 |
| 62 | muscle cell cellular homeostasis (GO:0046716) | 4.23913245 |
| 63 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 4.18436964 |
| 64 | cell communication involved in cardiac conduction (GO:0086065) | 4.17534975 |
| 65 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 4.13580699 |
| 66 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.09688596 |
| 67 | muscle contraction (GO:0006936) | 4.06470112 |
| 68 | response to inactivity (GO:0014854) | 4.05539268 |
| 69 | regulation of the force of heart contraction (GO:0002026) | 4.00328710 |
| 70 | polysaccharide catabolic process (GO:0000272) | 3.99792481 |
| 71 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.99415306 |
| 72 | regulation of sulfur metabolic process (GO:0042762) | 3.97626056 |
| 73 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.93702237 |
| 74 | 2-oxoglutarate metabolic process (GO:0006103) | 3.92314927 |
| 75 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.91400383 |
| 76 | striated muscle adaptation (GO:0014888) | 3.90421904 |
| 77 | carnitine transport (GO:0015879) | 3.87118806 |
| 78 | amino-acid betaine transport (GO:0015838) | 3.87118806 |
| 79 | muscle cell fate commitment (GO:0042693) | 3.85058782 |
| 80 | regulation of cardiac muscle contraction (GO:0055117) | 3.84907796 |
| 81 | NADH metabolic process (GO:0006734) | 3.84026351 |
| 82 | respiratory electron transport chain (GO:0022904) | 3.82216673 |
| 83 | muscle structure development (GO:0061061) | 3.80922771 |
| 84 | muscle organ development (GO:0007517) | 3.79835374 |
| 85 | positive regulation of myotube differentiation (GO:0010831) | 3.79550729 |
| 86 | oxidative phosphorylation (GO:0006119) | 3.78894225 |
| 87 | muscle system process (GO:0003012) | 3.78247733 |
| 88 | cardiac muscle adaptation (GO:0014887) | 3.77568244 |
| 89 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.77568244 |
| 90 | muscle hypertrophy in response to stress (GO:0003299) | 3.77568244 |
| 91 | muscle adaptation (GO:0043500) | 3.77453936 |
| 92 | regulation of sequestering of triglyceride (GO:0010889) | 3.72468631 |
| 93 | striated muscle cell development (GO:0055002) | 3.71351264 |
| 94 | glycogen metabolic process (GO:0005977) | 3.71131173 |
| 95 | cardiac muscle cell action potential (GO:0086001) | 3.70510697 |
| 96 | electron transport chain (GO:0022900) | 3.70187692 |
| 97 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.69458831 |
| 98 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.67774847 |
| 99 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.67774847 |
| 100 | relaxation of cardiac muscle (GO:0055119) | 3.67245742 |
| 101 | response to muscle activity (GO:0014850) | 3.66801721 |
| 102 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.66474371 |
| 103 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.66474371 |
| 104 | cellular glucan metabolic process (GO:0006073) | 3.63836240 |
| 105 | glucan metabolic process (GO:0044042) | 3.63836240 |
| 106 | negative regulation of potassium ion transport (GO:0043267) | 3.63323361 |
| 107 | positive regulation of cation channel activity (GO:2001259) | 3.62949134 |
| 108 | ATP synthesis coupled proton transport (GO:0015986) | 3.61916957 |
| 109 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.61916957 |
| 110 | glycogen catabolic process (GO:0005980) | 3.61621212 |
| 111 | striated muscle atrophy (GO:0014891) | 3.61300703 |
| 112 | regulation of heart rate (GO:0002027) | 3.60957919 |
| 113 | muscle atrophy (GO:0014889) | 3.60082091 |
| 114 | regulation of ATP catabolic process (GO:1903289) | 3.54067430 |
| 115 | regulation of ATPase activity (GO:0043462) | 3.54067430 |
| 116 | cell communication by electrical coupling (GO:0010644) | 3.48147659 |
| 117 | response to activity (GO:0014823) | 3.47694212 |
| 118 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.46171423 |
| 119 | relaxation of muscle (GO:0090075) | 3.44878609 |
| 120 | negative regulation of protein localization to cell surface (GO:2000009) | 3.44726997 |
| 121 | regulation of skeletal muscle cell differentiation (GO:2001014) | 3.42504139 |
| 122 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.40301946 |
| 123 | regulation of muscle system process (GO:0090257) | 3.37173823 |
| 124 | glucan catabolic process (GO:0009251) | 3.36603354 |
| 125 | muscle cell development (GO:0055001) | 3.36174363 |
| 126 | fructose metabolic process (GO:0006000) | 3.36083674 |
| 127 | regulation of heart contraction (GO:0008016) | 3.32591273 |
| 128 | muscle organ morphogenesis (GO:0048644) | 3.32380083 |
| 129 | regulation of myoblast differentiation (GO:0045661) | 3.32293396 |
| 130 | positive regulation of heart rate (GO:0010460) | 3.32267841 |
| 131 | myotube differentiation (GO:0014902) | 3.31663881 |
| 132 | striated muscle tissue development (GO:0014706) | 3.31317157 |
| 133 | regulation of muscle contraction (GO:0006937) | 3.30748270 |
| 134 | gluconeogenesis (GO:0006094) | 3.29357590 |
| 135 | myoblast fusion (GO:0007520) | 3.26732350 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 6.56914648 |
| 2 | * EP300_21415370_ChIP-Seq_HL-1_Mouse | 4.52661742 |
| 3 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.34895431 |
| 4 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 4.12234713 |
| 5 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 4.10535823 |
| 6 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 4.10535823 |
| 7 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.99489042 |
| 8 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.85302132 |
| 9 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.37495345 |
| 10 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.30866685 |
| 11 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 3.05789708 |
| 12 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.05197025 |
| 13 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.75247538 |
| 14 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.69288823 |
| 15 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.68250392 |
| 16 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.37874730 |
| 17 | * GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.32414495 |
| 18 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.29067251 |
| 19 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.27902467 |
| 20 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.02452948 |
| 21 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.90196918 |
| 22 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.72258629 |
| 23 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.71052508 |
| 24 | * NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.68540357 |
| 25 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.66175024 |
| 26 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.57767191 |
| 27 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.54359655 |
| 28 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.54332291 |
| 29 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.51306659 |
| 30 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.46722314 |
| 31 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.44784390 |
| 32 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.44474169 |
| 33 | GATA1_22025678_ChIP-Seq_K562_Human | 1.39672081 |
| 34 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.38063042 |
| 35 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.34539862 |
| 36 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.31013239 |
| 37 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.28118092 |
| 38 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.25341672 |
| 39 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.20642217 |
| 40 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.20616639 |
| 41 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.20100392 |
| 42 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.19613285 |
| 43 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.19306128 |
| 44 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.17870333 |
| 45 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.15069067 |
| 46 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.12289003 |
| 47 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.12243341 |
| 48 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.11372040 |
| 49 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.11309617 |
| 50 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.11123584 |
| 51 | * ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.09527151 |
| 52 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.08291789 |
| 53 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.06833875 |
| 54 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.05898390 |
| 55 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.05425668 |
| 56 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.04347617 |
| 57 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.03652369 |
| 58 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.03356785 |
| 59 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.02434566 |
| 60 | * CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.98919881 |
| 61 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.98902200 |
| 62 | VDR_22108803_ChIP-Seq_LS180_Human | 0.98403059 |
| 63 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.97728187 |
| 64 | GATA1_19941826_ChIP-Seq_K562_Human | 0.97617261 |
| 65 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.97306203 |
| 66 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.97220685 |
| 67 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.97064994 |
| 68 | * SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.96274529 |
| 69 | * EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.96206801 |
| 70 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.96096425 |
| 71 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.95775811 |
| 72 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.95383680 |
| 73 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.95332416 |
| 74 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.94115844 |
| 75 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93279436 |
| 76 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.92118661 |
| 77 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.92049317 |
| 78 | * CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.91893993 |
| 79 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.91440569 |
| 80 | * OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.91311959 |
| 81 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.90775464 |
| 82 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 0.90545156 |
| 83 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.90149646 |
| 84 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.89851543 |
| 85 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.88863743 |
| 86 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.88347479 |
| 87 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.88097435 |
| 88 | * NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.87905294 |
| 89 | * NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.87905294 |
| 90 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.87475173 |
| 91 | * CJUN_26792858_Chip-Seq_BT549_Human | 0.87465617 |
| 92 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.87407815 |
| 93 | ATF3_27146783_Chip-Seq_COLON_Human | 0.87188495 |
| 94 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.85964359 |
| 95 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.85655938 |
| 96 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.84791865 |
| 97 | GATA2_19941826_ChIP-Seq_K562_Human | 0.84726538 |
| 98 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.84276948 |
| 99 | P68_20966046_ChIP-Seq_HELA_Human | 0.84204299 |
| 100 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.84110491 |
| 101 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.83676334 |
| 102 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.83543294 |
| 103 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.82922276 |
| 104 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.82748912 |
| 105 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.82530097 |
| 106 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.81197369 |
| 107 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.80621859 |
| 108 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.80457199 |
| 109 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.80297372 |
| 110 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.80071601 |
| 111 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.79432402 |
| 112 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.79410667 |
| 113 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.78528170 |
| 114 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.78313543 |
| 115 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.78302570 |
| 116 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.78183851 |
| 117 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.77219808 |
| 118 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.76979012 |
| 119 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.76654614 |
| 120 | * AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.76211192 |
| 121 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.76152179 |
| 122 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.75619352 |
| 123 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.74948190 |
| 124 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.74744774 |
| 125 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73831755 |
| 126 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.73659128 |
| 127 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.73659128 |
| 128 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.73287084 |
| 129 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.73247369 |
| 130 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.72509491 |
| 131 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.72491944 |
| 132 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.71377728 |
| 133 | NFYB_21822215_ChIP-Seq_K562_Human | 0.71095462 |
| 134 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.70752524 |
| 135 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.70735875 |
| 136 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.70379067 |
| 137 | SPI1_23127762_ChIP-Seq_K562_Human | 0.70030811 |
| 138 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.69986213 |
| 139 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.69840072 |
| 140 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.69567220 |
| 141 | * PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.69520887 |
| 142 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.68422620 |
| 143 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.68392288 |
| 144 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.68276250 |
| 145 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.68276215 |
| 146 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.67642538 |
| 147 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.67608197 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 6.40215564 |
| 2 | MP0003646_muscle_fatigue | 6.28441750 |
| 3 | MP0000751_myopathy | 5.40970087 |
| 4 | MP0004084_abnormal_cardiac_muscle | 5.09670029 |
| 5 | MP0000749_muscle_degeneration | 4.53481138 |
| 6 | MP0004215_abnormal_myocardial_fiber | 4.35086538 |
| 7 | MP0004036_abnormal_muscle_relaxation | 4.34983300 |
| 8 | MP0005330_cardiomyopathy | 3.66185818 |
| 9 | MP0004145_abnormal_muscle_electrophysio | 3.63253128 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.28351817 |
| 11 | MP0002106_abnormal_muscle_physiology | 3.02224136 |
| 12 | MP0004130_abnormal_muscle_cell | 3.00268446 |
| 13 | MP0000750_abnormal_muscle_regeneration | 2.94240235 |
| 14 | MP0005620_abnormal_muscle_contractility | 2.89675834 |
| 15 | MP0002972_abnormal_cardiac_muscle | 2.87898159 |
| 16 | MP0002269_muscular_atrophy | 2.66039232 |
| 17 | MP0008775_abnormal_heart_ventricle | 2.65339941 |
| 18 | MP0003137_abnormal_impulse_conducting | 2.56364840 |
| 19 | MP0000747_muscle_weakness | 2.54756476 |
| 20 | MP0004484_altered_response_of | 2.50073175 |
| 21 | MP0005369_muscle_phenotype | 2.46419101 |
| 22 | MP0000759_abnormal_skeletal_muscle | 2.44225686 |
| 23 | MP0010630_abnormal_cardiac_muscle | 2.43557203 |
| 24 | MP0005385_cardiovascular_system_phenoty | 2.39368940 |
| 25 | MP0001544_abnormal_cardiovascular_syste | 2.39368940 |
| 26 | MP0006138_congestive_heart_failure | 2.04640095 |
| 27 | MP0004233_abnormal_muscle_weight | 1.96253597 |
| 28 | MP0003221_abnormal_cardiomyocyte_apopto | 1.95803730 |
| 29 | MP0003828_pulmonary_edema | 1.92844227 |
| 30 | MP0006036_abnormal_mitochondrial_physio | 1.88956261 |
| 31 | MP0004510_myositis | 1.87959631 |
| 32 | MP0004085_abnormal_heartbeat | 1.84323776 |
| 33 | MP0002332_abnormal_exercise_endurance | 1.69419781 |
| 34 | MP0005666_abnormal_adipose_tissue | 1.53596961 |
| 35 | MP0002127_abnormal_cardiovascular_syste | 1.51836435 |
| 36 | MP0003950_abnormal_plasma_membrane | 1.41790339 |
| 37 | MP0004270_analgesia | 1.32689674 |
| 38 | MP0005670_abnormal_white_adipose | 1.26370147 |
| 39 | MP0004185_abnormal_adipocyte_glucose | 1.23586381 |
| 40 | MP0000343_altered_response_to | 1.18267310 |
| 41 | MP0001661_extended_life_span | 1.16103982 |
| 42 | MP0002108_abnormal_muscle_morphology | 1.13747722 |
| 43 | MP0003567_abnormal_fetal_cardiomyocyte | 1.11632986 |
| 44 | MP0006035_abnormal_mitochondrial_morpho | 1.09695630 |
| 45 | MP0000266_abnormal_heart_morphology | 1.06278472 |
| 46 | MP0005375_adipose_tissue_phenotype | 1.02936445 |
| 47 | MP0002234_abnormal_pharynx_morphology | 0.99941436 |
| 48 | MP0005165_increased_susceptibility_to | 0.99492133 |
| 49 | MP0000733_abnormal_muscle_development | 0.97521720 |
| 50 | MP0005266_abnormal_metabolism | 0.90175716 |
| 51 | MP0010368_abnormal_lymphatic_system | 0.82470916 |
| 52 | MP0003279_aneurysm | 0.77344594 |
| 53 | MP0002971_abnormal_brown_adipose | 0.73890926 |
| 54 | MP0000230_abnormal_systemic_arterial | 0.73119898 |
| 55 | MP0003806_abnormal_nucleotide_metabolis | 0.71079051 |
| 56 | MP0004043_abnormal_pH_regulation | 0.70763732 |
| 57 | MP0002128_abnormal_blood_circulation | 0.69355922 |
| 58 | MP0000372_irregular_coat_pigmentation | 0.65898937 |
| 59 | MP0003705_abnormal_hypodermis_morpholog | 0.62737544 |
| 60 | MP0004147_increased_porphyrin_level | 0.60730034 |
| 61 | MP0003566_abnormal_cell_adhesion | 0.58252357 |
| 62 | MP0000013_abnormal_adipose_tissue | 0.56629743 |
| 63 | MP0000003_abnormal_adipose_tissue | 0.56610794 |
| 64 | MP0001879_abnormal_lymphatic_vessel | 0.55348342 |
| 65 | MP0005623_abnormal_meninges_morphology | 0.53875715 |
| 66 | MP0002078_abnormal_glucose_homeostasis | 0.53448270 |
| 67 | MP0003879_abnormal_hair_cell | 0.51916785 |
| 68 | MP0004134_abnormal_chest_morphology | 0.49220409 |
| 69 | MP0002909_abnormal_adrenal_gland | 0.48316941 |
| 70 | MP0000767_abnormal_smooth_muscle | 0.46742941 |
| 71 | MP0005451_abnormal_body_composition | 0.46264300 |
| 72 | MP0005319_abnormal_enzyme/_coenzyme | 0.45486834 |
| 73 | MP0008961_abnormal_basal_metabolism | 0.44482931 |
| 74 | MP0005167_abnormal_blood-brain_barrier | 0.43951065 |
| 75 | MP0005187_abnormal_penis_morphology | 0.43858167 |
| 76 | MP0008569_lethality_at_weaning | 0.41577985 |
| 77 | MP0005275_abnormal_skin_tensile | 0.41294582 |
| 78 | MP0004142_abnormal_muscle_tone | 0.40402504 |
| 79 | MP0005334_abnormal_fat_pad | 0.39416689 |
| 80 | MP0002925_abnormal_cardiovascular_devel | 0.37258935 |
| 81 | MP0003045_fibrosis | 0.37023626 |
| 82 | MP0010030_abnormal_orbit_morphology | 0.36096683 |
| 83 | MP0002638_abnormal_pupillary_reflex | 0.36001320 |
| 84 | MP0005535_abnormal_body_temperature | 0.35663287 |
| 85 | MP0005166_decreased_susceptibility_to | 0.33378429 |
| 86 | MP0008438_abnormal_cutaneous_collagen | 0.33097809 |
| 87 | MP0003948_abnormal_gas_homeostasis | 0.29692650 |
| 88 | MP0001614_abnormal_blood_vessel | 0.29219689 |
| 89 | MP0002114_abnormal_axial_skeleton | 0.28786910 |
| 90 | MP0009672_abnormal_birth_weight | 0.27844421 |
| 91 | MP0001784_abnormal_fluid_regulation | 0.27718014 |
| 92 | MP0009115_abnormal_fat_cell | 0.27217651 |
| 93 | MP0002896_abnormal_bone_mineralization | 0.26963351 |
| 94 | MP0001984_abnormal_olfaction | 0.26703766 |
| 95 | MP0001853_heart_inflammation | 0.26455365 |
| 96 | MP0000762_abnormal_tongue_morphology | 0.26263452 |
| 97 | MP0003984_embryonic_growth_retardation | 0.26164481 |
| 98 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.25662788 |
| 99 | MP0003195_calcinosis | 0.25536185 |
| 100 | MP0004272_abnormal_basement_membrane | 0.25510746 |
| 101 | MP0002822_catalepsy | 0.25217933 |
| 102 | MP0002088_abnormal_embryonic_growth/wei | 0.25054090 |
| 103 | MP0009250_abnormal_appendicular_skeleto | 0.24516009 |
| 104 | MP0002118_abnormal_lipid_homeostasis | 0.24442633 |
| 105 | MP0001346_abnormal_lacrimal_gland | 0.24227697 |
| 106 | MP0003656_abnormal_erythrocyte_physiolo | 0.23829514 |
| 107 | MP0002734_abnormal_mechanical_nocicepti | 0.22372221 |
| 108 | MP0005452_abnormal_adipose_tissue | 0.22191445 |
| 109 | MP0005386_behavior/neurological_phenoty | 0.22098089 |
| 110 | MP0004924_abnormal_behavior | 0.22098089 |
| 111 | MP0005423_abnormal_somatic_nervous | 0.21882164 |
| 112 | MP0005083_abnormal_biliary_tract | 0.20638333 |
| 113 | MP0001943_abnormal_respiration | 0.20371869 |
| 114 | MP0001727_abnormal_embryo_implantation | 0.20332293 |
| 115 | MP0009780_abnormal_chondrocyte_physiolo | 0.19501965 |
| 116 | MP0005332_abnormal_amino_acid | 0.18910378 |
| 117 | MP0009384_cardiac_valve_regurgitation | 0.18452939 |
| 118 | MP0006276_abnormal_autonomic_nervous | 0.17843677 |
| 119 | MP0005376_homeostasis/metabolism_phenot | 0.17762648 |
| 120 | MP0005595_abnormal_vascular_smooth | 0.17473145 |
| 121 | MP0002877_abnormal_melanocyte_morpholog | 0.17448643 |
| 122 | MP0001299_abnormal_eye_distance/ | 0.17406583 |
| 123 | MP0002066_abnormal_motor_capabilities/c | 0.17256721 |
| 124 | MP0009840_abnormal_foam_cell | 0.16690038 |
| 125 | MP0002249_abnormal_larynx_morphology | 0.15420611 |
| 126 | MP0008874_decreased_physiological_sensi | 0.11648348 |
| 127 | MP0002168_other_aberrant_phenotype | 0.11016009 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sudden death (HP:0001699) | 7.18666294 |
| 2 | Exercise-induced myalgia (HP:0003738) | 7.09352971 |
| 3 | Calf muscle hypertrophy (HP:0008981) | 6.90286322 |
| 4 | Exercise-induced muscle cramps (HP:0003710) | 6.89463407 |
| 5 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.73408858 |
| 6 | Ventricular tachycardia (HP:0004756) | 6.16933750 |
| 7 | Muscle fiber splitting (HP:0003555) | 5.95412394 |
| 8 | Myoglobinuria (HP:0002913) | 5.53731445 |
| 9 | Abnormality of the calf musculature (HP:0001430) | 5.34594008 |
| 10 | Hyporeflexia of lower limbs (HP:0002600) | 5.26309856 |
| 11 | Atrial fibrillation (HP:0005110) | 5.22315968 |
| 12 | Primary atrial arrhythmia (HP:0001692) | 4.88020371 |
| 13 | Muscle fiber inclusion bodies (HP:0100299) | 4.81055198 |
| 14 | Supraventricular tachycardia (HP:0004755) | 4.71313404 |
| 15 | Subaortic stenosis (HP:0001682) | 4.70639295 |
| 16 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.70639295 |
| 17 | Lipoatrophy (HP:0100578) | 4.68242257 |
| 18 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 4.67561205 |
| 19 | Supraventricular arrhythmia (HP:0005115) | 4.60613138 |
| 20 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.60401171 |
| 21 | EMG: myopathic abnormalities (HP:0003458) | 4.57929589 |
| 22 | Difficulty running (HP:0009046) | 4.42063367 |
| 23 | Right ventricular cardiomyopathy (HP:0011663) | 4.41646464 |
| 24 | Rhabdomyolysis (HP:0003201) | 4.35978418 |
| 25 | Increased connective tissue (HP:0009025) | 4.34552270 |
| 26 | Bundle branch block (HP:0011710) | 4.12638579 |
| 27 | Syncope (HP:0001279) | 4.09768798 |
| 28 | Calcaneovalgus deformity (HP:0001848) | 4.04509138 |
| 29 | Dilated cardiomyopathy (HP:0001644) | 4.00177650 |
| 30 | Nemaline bodies (HP:0003798) | 3.99340925 |
| 31 | Asymmetric septal hypertrophy (HP:0001670) | 3.87997386 |
| 32 | Palpitations (HP:0001962) | 3.87749892 |
| 33 | Type 1 muscle fiber predominance (HP:0003803) | 3.85397666 |
| 34 | Myotonia (HP:0002486) | 3.82398659 |
| 35 | Absent phalangeal crease (HP:0006109) | 3.66690339 |
| 36 | Prolonged QT interval (HP:0001657) | 3.60351428 |
| 37 | Deformed tarsal bones (HP:0008119) | 3.57768395 |
| 38 | Ventricular arrhythmia (HP:0004308) | 3.49054712 |
| 39 | Heart block (HP:0012722) | 3.44042993 |
| 40 | Muscle stiffness (HP:0003552) | 3.36171773 |
| 41 | Difficulty climbing stairs (HP:0003551) | 3.25274934 |
| 42 | Abnormal atrioventricular conduction (HP:0005150) | 3.24322033 |
| 43 | Atrioventricular block (HP:0001678) | 3.17959880 |
| 44 | Malignant hyperthermia (HP:0002047) | 3.15638082 |
| 45 | Abnormal finger flexion creases (HP:0006143) | 3.05723285 |
| 46 | Ventricular fibrillation (HP:0001663) | 2.96068376 |
| 47 | Increased variability in muscle fiber diameter (HP:0003557) | 2.92916377 |
| 48 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.90300668 |
| 49 | Areflexia of lower limbs (HP:0002522) | 2.89292272 |
| 50 | Distal lower limb muscle weakness (HP:0009053) | 2.86994194 |
| 51 | Distal arthrogryposis (HP:0005684) | 2.84672340 |
| 52 | Neck muscle weakness (HP:0000467) | 2.81444805 |
| 53 | Fetal akinesia sequence (HP:0001989) | 2.76188842 |
| 54 | Rimmed vacuoles (HP:0003805) | 2.71049446 |
| 55 | Myopathic facies (HP:0002058) | 2.70912690 |
| 56 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.66926945 |
| 57 | Left ventricular hypertrophy (HP:0001712) | 2.65714439 |
| 58 | Bulbar palsy (HP:0001283) | 2.63007544 |
| 59 | Hepatic necrosis (HP:0002605) | 2.62855265 |
| 60 | Abnormal EKG (HP:0003115) | 2.62132355 |
| 61 | Acute necrotizing encephalopathy (HP:0006965) | 2.60792022 |
| 62 | Round ear (HP:0100830) | 2.58377531 |
| 63 | Ketoacidosis (HP:0001993) | 2.52579172 |
| 64 | Limb-girdle muscle atrophy (HP:0003797) | 2.46440545 |
| 65 | Slender build (HP:0001533) | 2.41052101 |
| 66 | Hypoplastic ischia (HP:0003175) | 2.39896771 |
| 67 | Hyperkalemia (HP:0002153) | 2.37253047 |
| 68 | Weak cry (HP:0001612) | 2.36627910 |
| 69 | Palmoplantar keratoderma (HP:0000982) | 2.32622092 |
| 70 | Hypoglycemic coma (HP:0001325) | 2.31373607 |
| 71 | Abnormality of the calcaneus (HP:0008364) | 2.29010218 |
| 72 | Hepatocellular necrosis (HP:0001404) | 2.25409921 |
| 73 | Increased muscle lipid content (HP:0009058) | 2.25173182 |
| 74 | Fatigable weakness (HP:0003473) | 2.24809190 |
| 75 | Abnormality of the neuromuscular junction (HP:0003398) | 2.24809190 |
| 76 | Hip contracture (HP:0003273) | 2.24778448 |
| 77 | Acute encephalopathy (HP:0006846) | 2.24680159 |
| 78 | Muscular dystrophy (HP:0003560) | 2.24531046 |
| 79 | Distal lower limb amyotrophy (HP:0008944) | 2.17902939 |
| 80 | Progressive macrocephaly (HP:0004481) | 2.17291367 |
| 81 | Testicular atrophy (HP:0000029) | 2.16755626 |
| 82 | Spinal rigidity (HP:0003306) | 2.15758973 |
| 83 | Facial diplegia (HP:0001349) | 2.14936691 |
| 84 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.14882060 |
| 85 | EMG: neuropathic changes (HP:0003445) | 2.13789433 |
| 86 | Dicarboxylic aciduria (HP:0003215) | 2.11811200 |
| 87 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.11811200 |
| 88 | Exercise intolerance (HP:0003546) | 2.11651155 |
| 89 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.11490618 |
| 90 | Abnormality of alanine metabolism (HP:0010916) | 2.11490618 |
| 91 | Hyperalaninemia (HP:0003348) | 2.11490618 |
| 92 | Generalized muscle weakness (HP:0003324) | 2.11297483 |
| 93 | Ulnar deviation of the wrist (HP:0003049) | 2.10206862 |
| 94 | Mitochondrial inheritance (HP:0001427) | 2.09476940 |
| 95 | Abnormality of the ischium (HP:0003174) | 2.08710693 |
| 96 | Cerebral edema (HP:0002181) | 2.08253213 |
| 97 | Waddling gait (HP:0002515) | 2.06525272 |
| 98 | Gowers sign (HP:0003391) | 2.06146806 |
| 99 | Conjunctival hamartoma (HP:0100780) | 2.03015581 |
| 100 | Increased CSF lactate (HP:0002490) | 2.02401624 |
| 101 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.99663994 |
| 102 | Frequent falls (HP:0002359) | 1.98947838 |
| 103 | Increased intramyocellular lipid droplets (HP:0012240) | 1.97586054 |
| 104 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.97414343 |
| 105 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.96829080 |
| 106 | Proximal amyotrophy (HP:0007126) | 1.95071553 |
| 107 | Scapular winging (HP:0003691) | 1.93627275 |
| 108 | Abnormality of the foot musculature (HP:0001436) | 1.93346041 |
| 109 | Foot dorsiflexor weakness (HP:0009027) | 1.91299640 |
| 110 | Lactic acidosis (HP:0003128) | 1.89323389 |
| 111 | Large for gestational age (HP:0001520) | 1.87815400 |
| 112 | Ketosis (HP:0001946) | 1.86363900 |
| 113 | Lower limb amyotrophy (HP:0007210) | 1.84971584 |
| 114 | Ragged-red muscle fibers (HP:0003200) | 1.82654471 |
| 115 | Progressive muscle weakness (HP:0003323) | 1.82046862 |
| 116 | Congestive heart failure (HP:0001635) | 1.81765237 |
| 117 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.81753364 |
| 118 | Sudden cardiac death (HP:0001645) | 1.81384257 |
| 119 | Limb-girdle muscle weakness (HP:0003325) | 1.80154343 |
| 120 | Popliteal pterygium (HP:0009756) | 1.78943109 |
| 121 | Respiratory failure (HP:0002878) | 1.78231748 |
| 122 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.76003046 |
| 123 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.76003046 |
| 124 | Metatarsus adductus (HP:0001840) | 1.72306017 |
| 125 | Long clavicles (HP:0000890) | 1.70071406 |
| 126 | Nonprogressive disorder (HP:0003680) | 1.66815638 |
| 127 | Pelvic girdle muscle weakness (HP:0003749) | 1.66735690 |
| 128 | Shoulder girdle muscle weakness (HP:0003547) | 1.66153241 |
| 129 | Oligomenorrhea (HP:0000876) | 1.58694888 |
| 130 | Ulnar deviation of finger (HP:0009465) | 1.56849250 |
| 131 | Steppage gait (HP:0003376) | 1.55995774 |
| 132 | Type 2 muscle fiber atrophy (HP:0003554) | 1.55835433 |
| 133 | Limited hip movement (HP:0008800) | 1.52057410 |
| 134 | Paralysis (HP:0003470) | 1.48339834 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 6.51061889 |
| 2 | OBSCN | 5.89780329 |
| 3 | PHKG1 | 4.74332072 |
| 4 | PHKG2 | 4.74332072 |
| 5 | PDK4 | 3.45526987 |
| 6 | PDK3 | 3.45526987 |
| 7 | LMTK2 | 3.03108051 |
| 8 | DMPK | 2.93740733 |
| 9 | MYLK | 2.73604529 |
| 10 | PKN2 | 2.44559570 |
| 11 | TRIB3 | 2.37725776 |
| 12 | BCKDK | 2.34739144 |
| 13 | NEK1 | 2.31570681 |
| 14 | PINK1 | 2.30137777 |
| 15 | PIK3CA | 2.17429604 |
| 16 | PDK2 | 2.15990206 |
| 17 | MUSK | 2.08566165 |
| 18 | TIE1 | 1.73787405 |
| 19 | STK24 | 1.72994328 |
| 20 | GRK7 | 1.59267969 |
| 21 | MAP2K3 | 1.40906513 |
| 22 | MAP3K7 | 1.38635801 |
| 23 | NME1 | 1.30961666 |
| 24 | MAPK12 | 1.17798960 |
| 25 | MARK1 | 1.12574013 |
| 26 | CAMK2D | 1.12018090 |
| 27 | PRKD1 | 1.07582559 |
| 28 | EEF2K | 1.06512771 |
| 29 | PAK3 | 1.05779918 |
| 30 | ZAK | 1.04612960 |
| 31 | PIK3CG | 1.04169806 |
| 32 | CCNB1 | 0.99360685 |
| 33 | LIMK1 | 0.96975196 |
| 34 | ILK | 0.94880201 |
| 35 | INSRR | 0.94188595 |
| 36 | PRKAA2 | 0.93955259 |
| 37 | PRKAA1 | 0.93655785 |
| 38 | TRPM7 | 0.92360257 |
| 39 | MOS | 0.85895881 |
| 40 | ROCK1 | 0.77319816 |
| 41 | MAPKAPK3 | 0.75947636 |
| 42 | ERBB3 | 0.73130258 |
| 43 | PKN1 | 0.72483813 |
| 44 | STK4 | 0.71700438 |
| 45 | NEK9 | 0.70226680 |
| 46 | MAP3K3 | 0.69433532 |
| 47 | MAP3K5 | 0.69363679 |
| 48 | RIPK1 | 0.69289549 |
| 49 | STK38L | 0.68785576 |
| 50 | FLT3 | 0.66646053 |
| 51 | CAMK4 | 0.65073799 |
| 52 | WNK4 | 0.64855842 |
| 53 | DYRK1B | 0.60294379 |
| 54 | CDC42BPA | 0.58290156 |
| 55 | MAP3K13 | 0.55890872 |
| 56 | WNK1 | 0.54886750 |
| 57 | EPHB1 | 0.54592109 |
| 58 | PDGFRA | 0.52139528 |
| 59 | MAPK4 | 0.51716750 |
| 60 | MAP2K4 | 0.50718966 |
| 61 | TGFBR2 | 0.48909423 |
| 62 | CAMK2A | 0.48527614 |
| 63 | PRKACB | 0.45704510 |
| 64 | MAP2K1 | 0.45420446 |
| 65 | STK38 | 0.45032088 |
| 66 | CAMK2G | 0.43447623 |
| 67 | ROCK2 | 0.43189232 |
| 68 | AKT2 | 0.42359371 |
| 69 | CAMK2B | 0.41776055 |
| 70 | KSR2 | 0.41696239 |
| 71 | SGK2 | 0.41625036 |
| 72 | MAP2K6 | 0.41405733 |
| 73 | RPS6KC1 | 0.40962435 |
| 74 | RPS6KL1 | 0.40962435 |
| 75 | KDR | 0.39177400 |
| 76 | CAMK1 | 0.38930300 |
| 77 | DAPK3 | 0.38172370 |
| 78 | PRKACA | 0.37962188 |
| 79 | SIK1 | 0.35320872 |
| 80 | PRKACG | 0.34655782 |
| 81 | RPS6KA6 | 0.33911180 |
| 82 | PDPK1 | 0.33660368 |
| 83 | ICK | 0.30947907 |
| 84 | TBK1 | 0.29961755 |
| 85 | PDK1 | 0.28403276 |
| 86 | PTK2B | 0.27810299 |
| 87 | PRKCE | 0.27639288 |
| 88 | MAP3K10 | 0.26680060 |
| 89 | PTK6 | 0.26297258 |
| 90 | LATS1 | 0.26267010 |
| 91 | MAPK11 | 0.26057439 |
| 92 | EPHA3 | 0.26013743 |
| 93 | RPS6KA1 | 0.25789853 |
| 94 | SGK1 | 0.24632599 |
| 95 | MARK2 | 0.23132846 |
| 96 | RPS6KB1 | 0.23023141 |
| 97 | MAPK10 | 0.22717517 |
| 98 | PRKG1 | 0.22600223 |
| 99 | SGK3 | 0.22595394 |
| 100 | PRKCH | 0.22099521 |
| 101 | STK39 | 0.20895975 |
| 102 | JAK1 | 0.19711703 |
| 103 | SGK494 | 0.18888744 |
| 104 | SGK223 | 0.18888744 |
| 105 | NME2 | 0.18789216 |
| 106 | MAPK7 | 0.18765888 |
| 107 | STK11 | 0.18319094 |
| 108 | NLK | 0.18219830 |
| 109 | RPS6KA3 | 0.17814637 |
| 110 | MAPK13 | 0.17258057 |
| 111 | MAP3K11 | 0.15748544 |
| 112 | LATS2 | 0.15150151 |
| 113 | MAP3K6 | 0.14919273 |
| 114 | ZAP70 | 0.14674125 |
| 115 | MTOR | 0.14006091 |
| 116 | TAOK1 | 0.13791051 |
| 117 | MAPK15 | 0.13443767 |
| 118 | RPS6KB2 | 0.13230746 |
| 119 | MAP3K1 | 0.12515383 |
| 120 | RET | 0.12203694 |
| 121 | FER | 0.11100758 |
| 122 | PRKD3 | 0.10309207 |
| 123 | FGFR3 | 0.09630646 |
| 124 | TAOK2 | 0.09457940 |
| 125 | PRPF4B | 0.08768724 |
| 126 | EPHB2 | 0.07524418 |
| 127 | JAK2 | 0.07173263 |
| 128 | MARK3 | 0.07123037 |
| 129 | DAPK2 | 0.06855799 |
| 130 | FGFR4 | 0.06808038 |
| 131 | RPS6KA2 | 0.06276313 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.90559375 |
| 2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.27134506 |
| 3 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.15376775 |
| 4 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.80830013 |
| 5 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.75001384 |
| 6 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.35834468 |
| 7 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.22851085 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.96216361 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.84304945 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.82034163 |
| 11 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.78499092 |
| 12 | Carbon metabolism_Homo sapiens_hsa01200 | 2.48456025 |
| 13 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.33555699 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 2.25544905 |
| 15 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.15044498 |
| 16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.10441300 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.77467099 |
| 18 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.76444843 |
| 19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.74124025 |
| 20 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.70158676 |
| 21 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.37680566 |
| 22 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.35398647 |
| 23 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.33718465 |
| 24 | Insulin resistance_Homo sapiens_hsa04931 | 1.29694176 |
| 25 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.29435868 |
| 26 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.22433615 |
| 27 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.21104457 |
| 28 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.16497692 |
| 29 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.14640614 |
| 30 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.11369795 |
| 31 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.09166074 |
| 32 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.02230951 |
| 33 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.01261320 |
| 34 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.94259928 |
| 35 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.88951644 |
| 36 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.88025487 |
| 37 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.87359091 |
| 38 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.80955857 |
| 39 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.77335786 |
| 40 | Galactose metabolism_Homo sapiens_hsa00052 | 0.74872917 |
| 41 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.74807097 |
| 42 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.72356630 |
| 43 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.72160784 |
| 44 | Focal adhesion_Homo sapiens_hsa04510 | 0.70997373 |
| 45 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.70881525 |
| 46 | Lysine degradation_Homo sapiens_hsa00310 | 0.69838164 |
| 47 | Long-term potentiation_Homo sapiens_hsa04720 | 0.67655194 |
| 48 | Circadian rhythm_Homo sapiens_hsa04710 | 0.66398216 |
| 49 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.65959735 |
| 50 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.65040788 |
| 51 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.64829571 |
| 52 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.61887413 |
| 53 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.58563180 |
| 54 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.57043855 |
| 55 | Salivary secretion_Homo sapiens_hsa04970 | 0.56231968 |
| 56 | Tight junction_Homo sapiens_hsa04530 | 0.56048207 |
| 57 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.51524853 |
| 58 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.50970238 |
| 59 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.50747054 |
| 60 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.47589907 |
| 61 | Renin secretion_Homo sapiens_hsa04924 | 0.46307193 |
| 62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.46144930 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.45569426 |
| 64 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.45424362 |
| 65 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.44163962 |
| 66 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.43400998 |
| 67 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.40437292 |
| 68 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.38400800 |
| 69 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.37853936 |
| 70 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.36657306 |
| 71 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.36461255 |
| 72 | Adherens junction_Homo sapiens_hsa04520 | 0.36088137 |
| 73 | Insulin secretion_Homo sapiens_hsa04911 | 0.34407406 |
| 74 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.32096765 |
| 75 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.32039616 |
| 76 | Long-term depression_Homo sapiens_hsa04730 | 0.31919947 |
| 77 | Histidine metabolism_Homo sapiens_hsa00340 | 0.27856324 |
| 78 | Amoebiasis_Homo sapiens_hsa05146 | 0.27421808 |
| 79 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.25605727 |
| 80 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.24626922 |
| 81 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.23845508 |
| 82 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.22343835 |
| 83 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.21439413 |
| 84 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.21266048 |
| 85 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.21228766 |
| 86 | Metabolic pathways_Homo sapiens_hsa01100 | 0.21180217 |
| 87 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.20924349 |
| 88 | Platelet activation_Homo sapiens_hsa04611 | 0.20238438 |
| 89 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.19936606 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.19721094 |
| 91 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.19482620 |
| 92 | Circadian entrainment_Homo sapiens_hsa04713 | 0.18108720 |
| 93 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.18079494 |
| 94 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.17715917 |
| 95 | Melanogenesis_Homo sapiens_hsa04916 | 0.17211007 |
| 96 | Glioma_Homo sapiens_hsa05214 | 0.16729846 |
| 97 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.14577997 |
| 98 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.14171344 |
| 99 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.12065369 |
| 100 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.11579784 |
| 101 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.11184736 |
| 102 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.10753320 |
| 103 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.09674888 |
| 104 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.08943478 |
| 105 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.08927450 |
| 106 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.07188052 |
| 107 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.06626259 |
| 108 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.06172527 |
| 109 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.06082613 |
| 110 | Gap junction_Homo sapiens_hsa04540 | 0.03150325 |
| 111 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.02207404 |
| 112 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | -0.0579346 |
| 113 | Small cell lung cancer_Homo sapiens_hsa05222 | -0.0558169 |
| 114 | Notch signaling pathway_Homo sapiens_hsa04330 | -0.0550640 |
| 115 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | -0.0423954 |
| 116 | Bile secretion_Homo sapiens_hsa04976 | -0.0338987 |
| 117 | ABC transporters_Homo sapiens_hsa02010 | -0.0147634 |

