TXLNG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.70051622
2DNA unwinding involved in DNA replication (GO:0006268)4.67595257
3nuclear pore organization (GO:0006999)4.65461887
4mitotic metaphase plate congression (GO:0007080)4.57637990
5DNA strand elongation (GO:0022616)4.51542515
6protein localization to kinetochore (GO:0034501)4.24284011
7establishment of integrated proviral latency (GO:0075713)4.18369844
8nuclear pore complex assembly (GO:0051292)4.14808782
9metaphase plate congression (GO:0051310)4.01595129
10kinetochore organization (GO:0051383)3.97739722
11protein localization to chromosome, centromeric region (GO:0071459)3.86936572
12kinetochore assembly (GO:0051382)3.86674141
13regulation of spindle organization (GO:0090224)3.85906385
14sister chromatid segregation (GO:0000819)3.83235194
15CENP-A containing nucleosome assembly (GO:0034080)3.78669295
16formation of translation preinitiation complex (GO:0001731)3.78437246
17regulation of helicase activity (GO:0051095)3.76409709
18double-strand break repair via nonhomologous end joining (GO:0006303)3.73735906
19non-recombinational repair (GO:0000726)3.73735906
20chromatin remodeling at centromere (GO:0031055)3.73177663
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.68153393
22ribosome assembly (GO:0042255)3.65258362
23protein K6-linked ubiquitination (GO:0085020)3.65059854
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.64589437
25purine nucleobase biosynthetic process (GO:0009113)3.64247969
26protein complex localization (GO:0031503)3.57833616
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.56914694
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.56914694
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.56914694
30DNA replication checkpoint (GO:0000076)3.56151579
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.53859563
32regulation of translational fidelity (GO:0006450)3.52572145
33replication fork processing (GO:0031297)3.51248621
34attachment of spindle microtubules to kinetochore (GO:0008608)3.51222456
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50741331
36transcription from mitochondrial promoter (GO:0006390)3.47465106
37DNA replication initiation (GO:0006270)3.47442328
38maturation of 5.8S rRNA (GO:0000460)3.46210033
39regulation of centriole replication (GO:0046599)3.46209133
40nucleobase biosynthetic process (GO:0046112)3.44631473
41DNA replication-independent nucleosome assembly (GO:0006336)3.44428751
42DNA replication-independent nucleosome organization (GO:0034724)3.44428751
43serine family amino acid catabolic process (GO:0009071)3.42846902
44telomere maintenance via telomerase (GO:0007004)3.40570275
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.39371360
46meiotic chromosome segregation (GO:0045132)3.35720401
47ribosomal large subunit biogenesis (GO:0042273)3.34861581
48folic acid-containing compound biosynthetic process (GO:0009396)3.34161583
49cellular protein complex localization (GO:0034629)3.34134622
50DNA topological change (GO:0006265)3.32721980
51rRNA modification (GO:0000154)3.32643816
52mitotic sister chromatid cohesion (GO:0007064)3.30236188
53ribosome biogenesis (GO:0042254)3.27987267
54tRNA aminoacylation for protein translation (GO:0006418)3.27321265
55IMP biosynthetic process (GO:0006188)3.25780267
56establishment of viral latency (GO:0019043)3.24482472
57mitotic nuclear envelope disassembly (GO:0007077)3.24144819
58establishment of chromosome localization (GO:0051303)3.23665547
59amino acid activation (GO:0043038)3.22680232
60tRNA aminoacylation (GO:0043039)3.22680232
61positive regulation of chromosome segregation (GO:0051984)3.21658615
62rRNA methylation (GO:0031167)3.20083335
63DNA duplex unwinding (GO:0032508)3.18882543
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16281420
65DNA synthesis involved in DNA repair (GO:0000731)3.14033609
66DNA double-strand break processing (GO:0000729)3.12552627
67DNA geometric change (GO:0032392)3.12516584
68mitochondrial RNA metabolic process (GO:0000959)3.11093912
69regulation of centrosome cycle (GO:0046605)3.11075261
70regulation of histone H3-K27 methylation (GO:0061085)3.10903217
71regulation of mitotic spindle organization (GO:0060236)3.06448716
72glycine metabolic process (GO:0006544)3.05759715
73histone exchange (GO:0043486)3.05259009
74heterochromatin organization (GO:0070828)3.05041181
75ribonucleoprotein complex biogenesis (GO:0022613)3.04218431
76pore complex assembly (GO:0046931)3.00275291
77DNA replication-dependent nucleosome organization (GO:0034723)2.99374123
78DNA replication-dependent nucleosome assembly (GO:0006335)2.99374123
79rRNA processing (GO:0006364)2.96732513
80membrane disassembly (GO:0030397)2.96541670
81nuclear envelope disassembly (GO:0051081)2.96541670
82negative regulation of mRNA processing (GO:0050686)2.96205065
83ATP-dependent chromatin remodeling (GO:0043044)2.96011487
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95227913
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95063948
86regulation of mitotic spindle checkpoint (GO:1903504)2.95063948
87mitotic chromosome condensation (GO:0007076)2.92988793
88RNA-dependent DNA replication (GO:0006278)2.92316744
89nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.91270575
90regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90696328
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90380357
92sister chromatid cohesion (GO:0007062)2.89094166
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88922265
94folic acid metabolic process (GO:0046655)2.87160734
95regulation of sister chromatid segregation (GO:0033045)2.86352710
96regulation of mitotic sister chromatid separation (GO:0010965)2.86352710
97regulation of mitotic sister chromatid segregation (GO:0033047)2.86352710
98spindle checkpoint (GO:0031577)2.83477368
99IMP metabolic process (GO:0046040)2.83324504
100telomere maintenance via semi-conservative replication (GO:0032201)2.83192048
101intra-S DNA damage checkpoint (GO:0031573)2.80090598
102reciprocal DNA recombination (GO:0035825)2.76978520
103reciprocal meiotic recombination (GO:0007131)2.76978520
104mitotic sister chromatid segregation (GO:0000070)2.76502631
105telomere maintenance via recombination (GO:0000722)2.76041874
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.73158487
107somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73158487
108negative regulation of chromosome segregation (GO:0051985)2.72292315
109somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71543742
110isotype switching (GO:0045190)2.71543742
111somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71543742
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71381791
113negative regulation of mitotic sister chromatid separation (GO:2000816)2.71217796
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71217796
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71217796
116negative regulation of sister chromatid segregation (GO:0033046)2.71217796
117telomere maintenance via telomere lengthening (GO:0010833)2.70564511
118spindle assembly checkpoint (GO:0071173)2.68636080
119poly(A)+ mRNA export from nucleus (GO:0016973)2.68543573
120regulation of DNA-dependent DNA replication (GO:0090329)2.67693344
121monoubiquitinated protein deubiquitination (GO:0035520)2.67614671
122inner cell mass cell proliferation (GO:0001833)2.66776301
123tryptophan metabolic process (GO:0006568)2.65464169
124mitotic spindle assembly checkpoint (GO:0007094)2.65338397
125regulation of DNA endoreduplication (GO:0032875)2.63963576
126viral mRNA export from host cell nucleus (GO:0046784)2.63848726
127histone H2A monoubiquitination (GO:0035518)2.63049911
128chromatin assembly or disassembly (GO:0006333)2.62565159
129regulation of RNA export from nucleus (GO:0046831)2.62423834
130mitotic recombination (GO:0006312)2.61621130
131mitotic spindle checkpoint (GO:0071174)2.61260794
132telomere maintenance (GO:0000723)2.58990468
133regulation of chromosome segregation (GO:0051983)2.58938188
134indole-containing compound catabolic process (GO:0042436)2.57214307
135indolalkylamine catabolic process (GO:0046218)2.57214307
136tryptophan catabolic process (GO:0006569)2.57214307
137telomere organization (GO:0032200)2.56604500
138amine catabolic process (GO:0009310)2.56373660
139cellular biogenic amine catabolic process (GO:0042402)2.56373660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.04066616
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.78309067
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.45077620
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.22185332
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05777393
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80634492
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.76184153
8* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74726089
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.70743014
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70144249
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37424759
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.24881619
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19169734
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18479630
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17068184
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.15006412
17AR_21909140_ChIP-Seq_LNCAP_Human2.14194236
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10896526
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07200123
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05401029
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04443146
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04097584
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03128028
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93177241
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.92962961
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91743019
27VDR_23849224_ChIP-Seq_CD4+_Human1.91461389
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89138360
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.88117805
30ELK1_19687146_ChIP-ChIP_HELA_Human1.83083567
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76104387
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75980982
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.66396511
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65567497
35FOXP3_21729870_ChIP-Seq_TREG_Human1.64574676
36CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60978921
37IRF1_19129219_ChIP-ChIP_H3396_Human1.60153777
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.58769131
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.58651346
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58048232
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56570621
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56557036
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54114338
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.50933022
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46573280
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44613387
47E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.43137058
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42833174
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41366392
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39169289
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34657024
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34050516
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32946367
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32837465
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.32397383
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32373935
57KDM5A_27292631_Chip-Seq_BREAST_Human1.31946208
58TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31311178
59NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.31110135
60GABP_19822575_ChIP-Seq_HepG2_Human1.30805210
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28181371
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.27964688
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.26011165
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25134498
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23631047
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23274563
67* TFEB_21752829_ChIP-Seq_HELA_Human1.23172441
68XRN2_22483619_ChIP-Seq_HELA_Human1.21770015
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21690757
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20045291
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19761695
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19121544
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19121544
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19121544
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16998423
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16050913
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15624408
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14929375
79DCP1A_22483619_ChIP-Seq_HELA_Human1.13842641
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12260035
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10579491
82CHD1_26751641_Chip-Seq_LNCaP_Human1.10200707
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10051302
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09325372
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09008169
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08711322
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08358107
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06496851
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06170093
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05913985
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04750885
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04644300
93MYC_18940864_ChIP-ChIP_HL60_Human1.04419866
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04274972
95NANOG_16153702_ChIP-ChIP_HESCs_Human1.04231675
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.04207949
97GATA1_22025678_ChIP-Seq_K562_Human1.02769336
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01670256
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01337857
100CIITA_25753668_ChIP-Seq_RAJI_Human0.99510998
101* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99295560
102TTF2_22483619_ChIP-Seq_HELA_Human0.97823797
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.97407920
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97209587
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.96147994
106EWS_26573619_Chip-Seq_HEK293_Human0.94493805
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91411817
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90533997
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.90009443
110SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88761774
111NFE2_27457419_Chip-Seq_LIVER_Mouse0.88364663
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87722164
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87671510
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87000310
115MYC_22102868_ChIP-Seq_BL_Human0.86739373
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86513330
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86492908
118YY1_21170310_ChIP-Seq_MESCs_Mouse0.86056150
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85606124
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85433354
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85384225
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84764736
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.84077502
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82732202
125FUS_26573619_Chip-Seq_HEK293_Human0.76371495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.79667254
2MP0010094_abnormal_chromosome_stability3.64647553
3MP0008057_abnormal_DNA_replication3.54530993
4MP0002139_abnormal_hepatobiliary_system3.44867877
5MP0005365_abnormal_bile_salt3.38104571
6MP0005670_abnormal_white_adipose3.21651983
7MP0008058_abnormal_DNA_repair3.19807236
8MP0003111_abnormal_nucleus_morphology3.10583129
9MP0005085_abnormal_gallbladder_physiolo3.03367045
10MP0003941_abnormal_skin_development2.74468917
11MP0003077_abnormal_cell_cycle2.74154771
12MP0009697_abnormal_copulation2.59173079
13MP0003718_maternal_effect2.58662795
14MP0004957_abnormal_blastocyst_morpholog2.57969907
15MP0003806_abnormal_nucleotide_metabolis2.54362419
16MP0002396_abnormal_hematopoietic_system2.50346219
17MP0005360_urolithiasis2.38175886
18MP0008877_abnormal_DNA_methylation2.38112050
19MP0008007_abnormal_cellular_replicative2.13808615
20MP0008875_abnormal_xenobiotic_pharmacok2.07215840
21MP0006292_abnormal_olfactory_placode1.99968538
22MP0010329_abnormal_lipoprotein_level1.76927440
23MP0002009_preneoplasia1.72523885
24MP0010307_abnormal_tumor_latency1.68331474
25MP0003786_premature_aging1.68284323
26MP0003186_abnormal_redox_activity1.61938017
27MP0002132_abnormal_respiratory_system1.56581348
28MP0003252_abnormal_bile_duct1.51833641
29MP0005451_abnormal_body_composition1.51130102
30MP0005075_abnormal_melanosome_morpholog1.50643814
31MP0005397_hematopoietic_system_phenotyp1.47539137
32MP0001545_abnormal_hematopoietic_system1.47539137
33MP0003123_paternal_imprinting1.43082979
34MP0004264_abnormal_extraembryonic_tissu1.42265115
35MP0003787_abnormal_imprinting1.39170574
36MP0004197_abnormal_fetal_growth/weight/1.38385508
37MP0003763_abnormal_thymus_physiology1.35953987
38MP0005647_abnormal_sex_gland1.34843987
39MP0001119_abnormal_female_reproductive1.34555477
40MP0000350_abnormal_cell_proliferation1.31234512
41MP0000609_abnormal_liver_physiology1.31153282
42MP0003221_abnormal_cardiomyocyte_apopto1.31067973
43MP0003937_abnormal_limbs/digits/tail_de1.29983599
44MP0002796_impaired_skin_barrier1.23908714
45MP0001293_anophthalmia1.23428766
46MP0001672_abnormal_embryogenesis/_devel1.23300024
47MP0005380_embryogenesis_phenotype1.23300024
48MP0010234_abnormal_vibrissa_follicle1.21279363
49MP0001730_embryonic_growth_arrest1.21257659
50MP0001188_hyperpigmentation1.20365361
51MP0009703_decreased_birth_body1.18172975
52MP0005501_abnormal_skin_physiology1.17558015
53MP0003890_abnormal_embryonic-extraembry1.14701458
54MP0004808_abnormal_hematopoietic_stem1.14456030
55MP0001764_abnormal_homeostasis1.14344614
56MP0004233_abnormal_muscle_weight1.13753330
57MP0006035_abnormal_mitochondrial_morpho1.12326472
58MP0003121_genomic_imprinting1.10293127
59MP0004185_abnormal_adipocyte_glucose1.09462471
60MP0008932_abnormal_embryonic_tissue1.08701619
61MP0002019_abnormal_tumor_incidence1.07359604
62MP0003699_abnormal_female_reproductive1.07248722
63MP0004147_increased_porphyrin_level1.07231819
64MP0002697_abnormal_eye_size1.06306856
65MP0000566_synostosis1.06275172
66MP0003136_yellow_coat_color1.06232384
67MP0002210_abnormal_sex_determination1.06156839
68MP0005395_other_phenotype1.02888878
69MP0001919_abnormal_reproductive_system1.02566721
70MP0002086_abnormal_extraembryonic_tissu1.01977159
71MP0004782_abnormal_surfactant_physiolog1.01816973
72MP0010352_gastrointestinal_tract_polyps1.01501010
73MP0005332_abnormal_amino_acid1.00662799
74MP0003984_embryonic_growth_retardation0.99335744
75MP0002938_white_spotting0.99241184
76MP0002006_tumorigenesis0.98524836
77MP0005076_abnormal_cell_differentiation0.98368568
78MP0000653_abnormal_sex_gland0.98235806
79MP0010030_abnormal_orbit_morphology0.97735237
80MP0001286_abnormal_eye_development0.96346324
81MP0002166_altered_tumor_susceptibility0.96058554
82MP0002160_abnormal_reproductive_system0.95525454
83MP0002088_abnormal_embryonic_growth/wei0.95125667
84MP0000358_abnormal_cell_content/0.94647358
85MP0001697_abnormal_embryo_size0.94426865
86MP0002095_abnormal_skin_pigmentation0.93869491
87MP0008260_abnormal_autophagy0.93615212
88MP0000490_abnormal_crypts_of0.92418362
89MP0002876_abnormal_thyroid_physiology0.90629423
90MP0000313_abnormal_cell_death0.90369471
91MP0001727_abnormal_embryo_implantation0.89819971
92MP0000689_abnormal_spleen_morphology0.89250713
93MP0001145_abnormal_male_reproductive0.88290908
94MP0000598_abnormal_liver_morphology0.87133904
95MP0005319_abnormal_enzyme/_coenzyme0.86261645
96MP0005389_reproductive_system_phenotype0.85746612
97MP0005666_abnormal_adipose_tissue0.85560062
98MP0000015_abnormal_ear_pigmentation0.83935880
99MP0003868_abnormal_feces_composition0.83617895
100MP0001929_abnormal_gametogenesis0.82294310
101MP0002877_abnormal_melanocyte_morpholog0.82106688
102MP0008995_early_reproductive_senescence0.82087189
103MP0001661_extended_life_span0.81827981
104MP0002398_abnormal_bone_marrow0.81625529
105MP0003119_abnormal_digestive_system0.80545879
106MP0002722_abnormal_immune_system0.80090062
107MP0002233_abnormal_nose_morphology0.80053243
108MP0002111_abnormal_tail_morphology0.79904614
109MP0000537_abnormal_urethra_morphology0.79778965
110MP0002084_abnormal_developmental_patter0.79384633
111MP0001986_abnormal_taste_sensitivity0.79183760
112MP0002254_reproductive_system_inflammat0.78426805
113MP0001853_heart_inflammation0.78158111
114MP0001915_intracranial_hemorrhage0.78153773
115MP0005384_cellular_phenotype0.78128675
116MP0000579_abnormal_nail_morphology0.76801944
117MP0008789_abnormal_olfactory_epithelium0.76684588
118MP0000703_abnormal_thymus_morphology0.76530010
119MP0002085_abnormal_embryonic_tissue0.76002779
120MP0002080_prenatal_lethality0.75659599
121MP0003861_abnormal_nervous_system0.75568306
122MP0006036_abnormal_mitochondrial_physio0.75059686
123MP0000427_abnormal_hair_cycle0.74019232
124MP0003315_abnormal_perineum_morphology0.73968114
125MP0003943_abnormal_hepatobiliary_system0.72194482
126MP0009672_abnormal_birth_weight0.71852013
127MP0003567_abnormal_fetal_cardiomyocyte0.71712048
128MP0001666_abnormal_nutrient_absorption0.70818481
129MP0003724_increased_susceptibility_to0.70815006
130MP0002118_abnormal_lipid_homeostasis0.70687697
131MP0009765_abnormal_xenobiotic_induced0.69445447
132MP0005621_abnormal_cell_physiology0.68658636
133MP0000428_abnormal_craniofacial_morphol0.68526655
134MP0003755_abnormal_palate_morphology0.65103375
135MP0002092_abnormal_eye_morphology0.64606700
136MP0005394_taste/olfaction_phenotype0.63689705
137MP0005499_abnormal_olfactory_system0.63689705
138MP0002161_abnormal_fertility/fecundity0.63327632
139MP0003698_abnormal_male_reproductive0.59948751
140MP0000049_abnormal_middle_ear0.58942681
141MP0003935_abnormal_craniofacial_develop0.58400615
142MP0001346_abnormal_lacrimal_gland0.57994593
143MP0000432_abnormal_head_morphology0.56094535
144MP0000627_abnormal_mammary_gland0.55271522
145MP0002177_abnormal_outer_ear0.54426579
146MP0001881_abnormal_mammary_gland0.54360324

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.70005182
2Birth length less than 3rd percentile (HP:0003561)4.67089624
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41289088
4Hyperglycinemia (HP:0002154)3.93096194
5Hypochromic microcytic anemia (HP:0004840)3.79004009
6Hyperglycinuria (HP:0003108)3.68541258
7Abnormality of the labia minora (HP:0012880)3.34297582
8Embryonal renal neoplasm (HP:0011794)3.33187864
9Abnormality of chromosome stability (HP:0003220)3.30382587
10Multiple enchondromatosis (HP:0005701)3.27169417
11Acute myeloid leukemia (HP:0004808)3.21721610
12Intrahepatic cholestasis (HP:0001406)3.03242105
13Abnormality of pyrimidine metabolism (HP:0004353)2.99692877
14Impulsivity (HP:0100710)2.98814126
15Abnormality of serum amino acid levels (HP:0003112)2.98338950
16Abnormality of glycine metabolism (HP:0010895)2.96140453
17Abnormality of serine family amino acid metabolism (HP:0010894)2.96140453
18Increased nuchal translucency (HP:0010880)2.90094444
19Abnormality of the preputium (HP:0100587)2.89123681
20Breast hypoplasia (HP:0003187)2.79447014
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.78842742
22Clubbing of toes (HP:0100760)2.69415963
23Meckel diverticulum (HP:0002245)2.69228528
24Patellar aplasia (HP:0006443)2.68112145
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.68069969
26Hypobetalipoproteinemia (HP:0003563)2.66854746
27Myelodysplasia (HP:0002863)2.64833424
28Medulloblastoma (HP:0002885)2.62419594
29Abnormal lung lobation (HP:0002101)2.57011481
30Volvulus (HP:0002580)2.56264207
31Abnormality of the fingertips (HP:0001211)2.55505223
32Entropion (HP:0000621)2.51549573
33Supernumerary spleens (HP:0009799)2.48774230
34Aplasia/Hypoplasia of the patella (HP:0006498)2.47762203
35Prolonged partial thromboplastin time (HP:0003645)2.47179035
36Abnormality of the ileum (HP:0001549)2.46741973
37Colon cancer (HP:0003003)2.42184548
38Progressive external ophthalmoplegia (HP:0000590)2.41169953
39Ependymoma (HP:0002888)2.38701320
40Oligodactyly (hands) (HP:0001180)2.36722782
41Abnormality of glycolysis (HP:0004366)2.35623641
42Fair hair (HP:0002286)2.32924216
43Facial cleft (HP:0002006)2.32748572
44Tubulointerstitial nephritis (HP:0001970)2.28933857
45Increased serum pyruvate (HP:0003542)2.28678058
46Cafe-au-lait spot (HP:0000957)2.25770310
47Stenosis of the external auditory canal (HP:0000402)2.25471073
48Microvesicular hepatic steatosis (HP:0001414)2.25179062
49Rhabdomyosarcoma (HP:0002859)2.24309138
50Cortical dysplasia (HP:0002539)2.24068748
51Renal cortical cysts (HP:0000803)2.22851902
52Abnormality of lateral ventricle (HP:0030047)2.22813073
53Progressive muscle weakness (HP:0003323)2.22252488
54Megaloblastic anemia (HP:0001889)2.22079026
55Choanal atresia (HP:0000453)2.21488466
56Abnormality of the columella (HP:0009929)2.17888956
57Chronic hepatic failure (HP:0100626)2.17539282
58Lip pit (HP:0100267)2.16926217
59Facial hemangioma (HP:0000329)2.16585615
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15485015
61Shawl scrotum (HP:0000049)2.14993800
62Horseshoe kidney (HP:0000085)2.14481510
63Reduced antithrombin III activity (HP:0001976)2.14224777
64Selective tooth agenesis (HP:0001592)2.13781769
65Abnormality of methionine metabolism (HP:0010901)2.13735584
66Squamous cell carcinoma (HP:0002860)2.13173776
67Abnormal spermatogenesis (HP:0008669)2.12711575
68Homocystinuria (HP:0002156)2.12505551
69Abnormality of homocysteine metabolism (HP:0010919)2.12505551
70Bone marrow hypocellularity (HP:0005528)2.10353010
71Epidermoid cyst (HP:0200040)2.09848837
72Aplastic anemia (HP:0001915)2.09118864
73Neoplasm of the adrenal cortex (HP:0100641)2.09050243
74Abnormality of the hepatic vasculature (HP:0006707)2.08676941
75Proximal placement of thumb (HP:0009623)2.08631439
76Spontaneous abortion (HP:0005268)2.08483448
77Abnormality of DNA repair (HP:0003254)2.07006487
78Macrocytic anemia (HP:0001972)2.05072447
79Triphalangeal thumb (HP:0001199)2.02756355
80Capillary hemangiomas (HP:0005306)2.01645052
81Glioma (HP:0009733)2.01641574
82Small intestinal stenosis (HP:0012848)2.01349902
83Duodenal stenosis (HP:0100867)2.01349902
84Sloping forehead (HP:0000340)2.00444416
85Hypolipoproteinemia (HP:0010981)1.99977531
86Embryonal neoplasm (HP:0002898)1.99606904
87Oral leukoplakia (HP:0002745)1.96949907
88Deviation of the thumb (HP:0009603)1.96200593
89Abnormality of the duodenum (HP:0002246)1.94737326
90Papillary thyroid carcinoma (HP:0002895)1.94729152
91Blepharitis (HP:0000498)1.94500210
92Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94256841
93Absent radius (HP:0003974)1.94117791
94Astrocytoma (HP:0009592)1.93863550
95Abnormality of the astrocytes (HP:0100707)1.93863550
96Prominent nose (HP:0000448)1.93495562
97Abnormality of cochlea (HP:0000375)1.93300028
98Ectopic kidney (HP:0000086)1.92994784
99Deep philtrum (HP:0002002)1.92122317
100Abnormality of sulfur amino acid metabolism (HP:0004339)1.91706277
101Hyperammonemia (HP:0001987)1.91406229
102Abnormality of alanine metabolism (HP:0010916)1.91228494
103Hyperalaninemia (HP:0003348)1.91228494
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91228494
105Poikiloderma (HP:0001029)1.91226327
106Premature ovarian failure (HP:0008209)1.90623027
107Portal hypertension (HP:0001409)1.90363305
108Abnormality of nucleobase metabolism (HP:0010932)1.89812639
109Pancreatic islet-cell hyperplasia (HP:0004510)1.89798491
110Urethral obstruction (HP:0000796)1.89629105
111Prostate neoplasm (HP:0100787)1.89065820
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88969716
113Ectropion (HP:0000656)1.88596704
114Neoplasm of the oral cavity (HP:0100649)1.88174141
115Depressed nasal tip (HP:0000437)1.88027873
116Abnormality of the prostate (HP:0008775)1.87469471
117Limb hypertonia (HP:0002509)1.87251538
118Overlapping toe (HP:0001845)1.86949381
119Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86744781
120Fat malabsorption (HP:0002630)1.86009093
121Septate vagina (HP:0001153)1.85932284
122Deep venous thrombosis (HP:0002625)1.85722300
123Diastasis recti (HP:0001540)1.85589236
124Reticulocytopenia (HP:0001896)1.85572522
125Nephroblastoma (Wilms tumor) (HP:0002667)1.84913580
126Truncal obesity (HP:0001956)1.83951696
127Atresia of the external auditory canal (HP:0000413)1.82329036
128Abnormality of the heme biosynthetic pathway (HP:0010472)1.82164300
129Carpal bone hypoplasia (HP:0001498)1.81893035
130Absent thumb (HP:0009777)1.80241405
131Type 2 muscle fiber atrophy (HP:0003554)1.79665990
132Sparse eyelashes (HP:0000653)1.79567227
133Azoospermia (HP:0000027)1.79184189
134Neoplasm of the colon (HP:0100273)1.78531835
135Bifid tongue (HP:0010297)1.78529067
136Cutaneous melanoma (HP:0012056)1.78362253
137Abnormality of the carotid arteries (HP:0005344)1.77983502
138Prominent metopic ridge (HP:0005487)1.77521513
139Oligodactyly (HP:0012165)1.77345573
140Aplasia involving forearm bones (HP:0009822)1.77172444
141Absent forearm bone (HP:0003953)1.77172444
142Abnormal umbilical cord blood vessels (HP:0011403)1.76848220
143Single umbilical artery (HP:0001195)1.76848220
144Abnormality of the fetal cardiovascular system (HP:0010948)1.76848220
145Abnormal number of incisors (HP:0011064)1.76205584
146Arteriovenous malformation (HP:0100026)1.76098971
147Clitoromegaly (HP:0000057)1.75653099
148Amaurosis fugax (HP:0100576)1.75392881
149Sensory axonal neuropathy (HP:0003390)1.71176391
150Postnatal microcephaly (HP:0005484)1.69430875
151Abnormality of cells of the erythroid lineage (HP:0012130)1.68986615
152Increased hepatocellular lipid droplets (HP:0006565)1.67950087
153Neuroblastoma (HP:0003006)1.62525243
154Primitive neuroectodermal tumor (HP:0030065)1.62525243
155Neuroblastic tumors (HP:0004376)1.62525243
156Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.62525243
157Hyperinsulinemic hypoglycemia (HP:0000825)1.61503412
158Neoplasm of the adrenal gland (HP:0100631)1.60245581
159Aplasia/Hypoplasia of the sternum (HP:0006714)1.59354091
160Increased serum lactate (HP:0002151)1.57296969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.67300622
2MKNK13.68335296
3CDC72.84026826
4WEE12.68511682
5PBK2.66268157
6NEK12.54492736
7BRSK22.41010773
8SRPK12.31293914
9AKT32.27162269
10PLK42.19906389
11BUB12.18198617
12MST42.16029945
13ACVR1B2.10255440
14STK38L2.08586102
15ZAK2.04617490
16LATS11.99346701
17EIF2AK11.96903966
18TNIK1.95192549
19TTK1.93575660
20FRK1.92830863
21CDK121.92042231
22TAF11.82398943
23EIF2AK31.68121179
24TRIM281.67603843
25PLK11.67341746
26TAOK31.66079057
27NEK21.65025062
28VRK21.60169142
29PDK21.55402692
30PLK31.55027645
31CHEK21.52402054
32SMG11.52271666
33ATR1.52190108
34FLT31.39076431
35BRD41.34730764
36EEF2K1.31040970
37CDK41.25251115
38CDK71.21063433
39MAP3K91.20563384
40MAP3K101.20307649
41SCYL21.17117022
42NUAK11.16871776
43TSSK61.16776953
44DYRK31.15327408
45STK31.14866860
46ERBB41.14794936
47AURKB1.12090618
48PNCK1.11960505
49MUSK1.11634293
50ATM1.09585041
51VRK11.08706294
52BCKDK1.01802574
53BMPR1B1.00629381
54SGK21.00403159
55KIT1.00337223
56MAP3K60.98275564
57TXK0.97644826
58MAP3K140.97131759
59EIF2AK20.96515213
60MAP3K130.92122790
61CHEK10.91371026
62JAK30.90354667
63CDK90.89793903
64BCR0.88650624
65CDK30.87066164
66RPS6KA40.85647136
67STK40.85547268
68PINK10.85185454
69NLK0.81257709
70CDK60.80438109
71BRSK10.77849982
72MAP2K70.77573683
73STK240.76545560
74CSNK1G10.75224909
75CDK20.72856754
76FGFR30.70777821
77CDK80.69649124
78NEK60.69347190
79MAP4K10.69045607
80PIM10.68314449
81TGFBR10.67563769
82TEC0.66549930
83CAMK1G0.66184529
84SGK30.65789884
85NEK90.64944210
86AURKA0.64400153
87FGFR20.60050911
88CHUK0.58117660
89PRKAA20.57126618
90CSNK1G30.56601811
91NME20.55977464
92FGFR10.54625717
93NME10.54368511
94CSNK2A20.54279267
95CCNB10.54152339
96STK160.53445913
97CDK10.52785712
98IRAK30.52719967
99BRAF0.52104019
100CSNK1A1L0.51944259
101CSNK2A10.51724583
102CAMK1D0.51650018
103ARAF0.49775005
104RAF10.49524438
105RPS6KB10.48908188
106CLK10.48080730
107IKBKB0.47739388
108MAP3K120.47698489
109MAPK110.46398569
110PAK40.45308740
111MST1R0.42857622
112CSNK1G20.42633083
113PASK0.41803593
114ERBB30.41343315
115MTOR0.39393726
116AKT20.38518861
117LATS20.38228524
118RPS6KB20.38210869
119YES10.37698427
120MAPK140.37541735
121MELK0.37151381
122MAP3K80.36988312
123GSK3B0.36798441
124ALK0.36394981
125STK100.36311751
126CSNK1E0.36284771
127EPHA20.35619226
128MAP2K30.34746377
129ZAP700.34290676
130TLK10.33996432
131PRKDC0.32807839
132PRKAA10.32184361
133PRKCI0.31841290
134SIK30.29476080

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20286922
2DNA replication_Homo sapiens_hsa030303.02235927
3Mismatch repair_Homo sapiens_hsa034302.90695868
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.35703189
5One carbon pool by folate_Homo sapiens_hsa006702.33845972
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.32474986
7Vitamin B6 metabolism_Homo sapiens_hsa007502.32216683
8Homologous recombination_Homo sapiens_hsa034402.27404990
9RNA transport_Homo sapiens_hsa030132.26851251
10RNA polymerase_Homo sapiens_hsa030202.26442506
11Fanconi anemia pathway_Homo sapiens_hsa034602.23150950
12RNA degradation_Homo sapiens_hsa030182.21488509
13Cell cycle_Homo sapiens_hsa041102.15343302
14Non-homologous end-joining_Homo sapiens_hsa034502.11134415
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95851209
16Nucleotide excision repair_Homo sapiens_hsa034201.92714861
17Basal transcription factors_Homo sapiens_hsa030221.88872135
18Spliceosome_Homo sapiens_hsa030401.87000924
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81919855
20Pyrimidine metabolism_Homo sapiens_hsa002401.80022131
21Base excision repair_Homo sapiens_hsa034101.75110815
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.70279741
23Protein export_Homo sapiens_hsa030601.67904457
24Folate biosynthesis_Homo sapiens_hsa007901.66821439
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66152779
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59700015
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59164801
28Selenocompound metabolism_Homo sapiens_hsa004501.58021168
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.47117340
30Caffeine metabolism_Homo sapiens_hsa002321.41887601
31beta-Alanine metabolism_Homo sapiens_hsa004101.39389963
32Pyruvate metabolism_Homo sapiens_hsa006201.33756005
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33591237
34p53 signaling pathway_Homo sapiens_hsa041151.33215976
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32566627
36Complement and coagulation cascades_Homo sapiens_hsa046101.30580877
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26035676
38Arginine biosynthesis_Homo sapiens_hsa002201.24295238
39Oocyte meiosis_Homo sapiens_hsa041141.21454549
40Propanoate metabolism_Homo sapiens_hsa006401.20817397
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16328412
42Tryptophan metabolism_Homo sapiens_hsa003801.16199072
43Steroid biosynthesis_Homo sapiens_hsa001001.15064089
44Peroxisome_Homo sapiens_hsa041461.10582216
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08700063
46PPAR signaling pathway_Homo sapiens_hsa033201.05211227
47Purine metabolism_Homo sapiens_hsa002301.04805374
48Fatty acid degradation_Homo sapiens_hsa000711.04400034
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.04334749
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03847827
51Lysine degradation_Homo sapiens_hsa003101.03297768
52Circadian rhythm_Homo sapiens_hsa047101.02829025
53mRNA surveillance pathway_Homo sapiens_hsa030151.02712011
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00939130
55Herpes simplex infection_Homo sapiens_hsa051680.98966161
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97443492
57Biosynthesis of amino acids_Homo sapiens_hsa012300.97234743
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96675431
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92323958
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91795726
61Vitamin digestion and absorption_Homo sapiens_hsa049770.88300671
62Nitrogen metabolism_Homo sapiens_hsa009100.86512642
63Retinol metabolism_Homo sapiens_hsa008300.83875939
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81835115
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80933246
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80639601
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78556093
68Chemical carcinogenesis_Homo sapiens_hsa052040.78494756
69Systemic lupus erythematosus_Homo sapiens_hsa053220.78013546
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76319438
71Staphylococcus aureus infection_Homo sapiens_hsa051500.75786370
72Huntingtons disease_Homo sapiens_hsa050160.73549736
73Regulation of autophagy_Homo sapiens_hsa041400.73137663
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.71336803
75Histidine metabolism_Homo sapiens_hsa003400.70314036
76Fatty acid metabolism_Homo sapiens_hsa012120.69355807
77Thyroid cancer_Homo sapiens_hsa052160.66714914
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66530657
79Pentose phosphate pathway_Homo sapiens_hsa000300.65167958
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64845080
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64421196
82Primary immunodeficiency_Homo sapiens_hsa053400.63763141
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62963280
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.61035806
85Butanoate metabolism_Homo sapiens_hsa006500.60474683
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60333065
87Starch and sucrose metabolism_Homo sapiens_hsa005000.60317184
88ABC transporters_Homo sapiens_hsa020100.59144636
89Phenylalanine metabolism_Homo sapiens_hsa003600.59036513
90Tyrosine metabolism_Homo sapiens_hsa003500.57737667
91Adherens junction_Homo sapiens_hsa045200.57462647
92Parkinsons disease_Homo sapiens_hsa050120.56294330
93Ribosome_Homo sapiens_hsa030100.55071301
94Sulfur relay system_Homo sapiens_hsa041220.55041724
95N-Glycan biosynthesis_Homo sapiens_hsa005100.54013165
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.51914708
97Carbon metabolism_Homo sapiens_hsa012000.51889948
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50529811
99Arginine and proline metabolism_Homo sapiens_hsa003300.49697764
100MicroRNAs in cancer_Homo sapiens_hsa052060.48721025
101Glutathione metabolism_Homo sapiens_hsa004800.48393828
102Autoimmune thyroid disease_Homo sapiens_hsa053200.47438450
103TGF-beta signaling pathway_Homo sapiens_hsa043500.45680378
104Colorectal cancer_Homo sapiens_hsa052100.45441357
105Proteasome_Homo sapiens_hsa030500.45060777
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.43505878
107Epstein-Barr virus infection_Homo sapiens_hsa051690.43126177
108Fatty acid elongation_Homo sapiens_hsa000620.42968726
109Hippo signaling pathway_Homo sapiens_hsa043900.41876446
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40612021
111Metabolic pathways_Homo sapiens_hsa011000.40406922
112Viral carcinogenesis_Homo sapiens_hsa052030.40394503
113Wnt signaling pathway_Homo sapiens_hsa043100.39389281
114Prostate cancer_Homo sapiens_hsa052150.38164004
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.37694154
116Oxidative phosphorylation_Homo sapiens_hsa001900.37195196
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.37019017
118Fatty acid biosynthesis_Homo sapiens_hsa000610.36966763
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35899791
120Glycerolipid metabolism_Homo sapiens_hsa005610.34252057
121Hematopoietic cell lineage_Homo sapiens_hsa046400.32219864
122Allograft rejection_Homo sapiens_hsa053300.31771889
123Galactose metabolism_Homo sapiens_hsa000520.31089416
124Chronic myeloid leukemia_Homo sapiens_hsa052200.28788230
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26418242
126Sulfur metabolism_Homo sapiens_hsa009200.23778903
127Melanoma_Homo sapiens_hsa052180.21350712
128HTLV-I infection_Homo sapiens_hsa051660.18293878
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14911679
130Alzheimers disease_Homo sapiens_hsa050100.14849611
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14151939
132Bladder cancer_Homo sapiens_hsa052190.12371807
133Tight junction_Homo sapiens_hsa045300.11783454
134Glucagon signaling pathway_Homo sapiens_hsa049220.09352774
135Pancreatic cancer_Homo sapiens_hsa052120.09204083
136AMPK signaling pathway_Homo sapiens_hsa041520.08348189
137Endometrial cancer_Homo sapiens_hsa052130.07884843
138Alcoholism_Homo sapiens_hsa050340.07671064

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