TXLNGY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)5.75641915
2histone H3-K36 demethylation (GO:0070544)5.68085549
3negative T cell selection (GO:0043383)5.56142764
4negative thymic T cell selection (GO:0045060)5.39421862
5positive regulation of gamma-delta T cell activation (GO:0046645)5.39243114
6positive thymic T cell selection (GO:0045059)5.16454903
7positive regulation of granulocyte differentiation (GO:0030854)5.15109103
8negative regulation of translation, ncRNA-mediated (GO:0040033)4.62694155
9regulation of translation, ncRNA-mediated (GO:0045974)4.62694155
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.62694155
11regulation of B cell receptor signaling pathway (GO:0050855)4.52155507
12cellular response to ethanol (GO:0071361)4.44355439
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.27059639
14plasma lipoprotein particle assembly (GO:0034377)4.24332448
15B cell receptor signaling pathway (GO:0050853)4.21420032
16regulation of gamma-delta T cell differentiation (GO:0045586)4.18834965
17T cell selection (GO:0045058)4.11973826
18positive regulation of B cell differentiation (GO:0045579)3.92096046
19V(D)J recombination (GO:0033151)3.88142438
20regulation of gamma-delta T cell activation (GO:0046643)3.87047226
21regulation of granulocyte differentiation (GO:0030852)3.73553616
22regulation of B cell differentiation (GO:0045577)3.73506962
23thymic T cell selection (GO:0045061)3.70029666
24mucosal-associated lymphoid tissue development (GO:0048537)3.63830022
25Peyers patch development (GO:0048541)3.63830022
26T cell migration (GO:0072678)3.54340856
27negative regulation of thymocyte apoptotic process (GO:0070244)3.52711979
28regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.47797991
29low-density lipoprotein particle remodeling (GO:0034374)3.46752248
30histone lysine demethylation (GO:0070076)3.44517519
31protein-lipid complex assembly (GO:0065005)3.43472508
32phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.36798205
33activated T cell proliferation (GO:0050798)3.35723676
34very-low-density lipoprotein particle assembly (GO:0034379)3.32936802
35regulation of apoptotic cell clearance (GO:2000425)3.28233417
36phospholipid efflux (GO:0033700)3.18659094
37histone demethylation (GO:0016577)3.18095989
38regulation of posttranscriptional gene silencing (GO:0060147)3.10767828
39regulation of gene silencing by miRNA (GO:0060964)3.10767828
40regulation of gene silencing by RNA (GO:0060966)3.10767828
41regulation of non-canonical Wnt signaling pathway (GO:2000050)3.05849259
42regulation of alpha-beta T cell proliferation (GO:0046640)3.02963995
43regulation of chromatin silencing (GO:0031935)3.02198751
44regulation of cholesterol esterification (GO:0010872)3.01112894
45antigen receptor-mediated signaling pathway (GO:0050851)3.00919958
46antigen processing and presentation of endogenous antigen (GO:0019883)2.94886242
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93819682
48interkinetic nuclear migration (GO:0022027)2.93730495
49cellular extravasation (GO:0045123)2.93555103
50plasma lipoprotein particle organization (GO:0071827)2.89673602
51cholesterol efflux (GO:0033344)2.88571464
52positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87933398
53positive regulation of chemokine secretion (GO:0090197)2.87900529
54plasma lipoprotein particle remodeling (GO:0034369)2.84029614
55protein-lipid complex remodeling (GO:0034368)2.84029614
56macromolecular complex remodeling (GO:0034367)2.84029614
57protein dealkylation (GO:0008214)2.83593289
58protein demethylation (GO:0006482)2.83593289
59high-density lipoprotein particle remodeling (GO:0034375)2.82888039
60mRNA splice site selection (GO:0006376)2.76619294
61ribosomal small subunit assembly (GO:0000028)2.76387648
62response to muramyl dipeptide (GO:0032495)2.76124173
63regulation of protein activation cascade (GO:2000257)2.75600773
64regulation of gene silencing (GO:0060968)2.75090936
65positive regulation by host of viral transcription (GO:0043923)2.74737440
66response to interleukin-15 (GO:0070672)2.72887566
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72495186
68immunoglobulin mediated immune response (GO:0016064)2.72165097
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71808247
70B cell mediated immunity (GO:0019724)2.70261743
71dosage compensation (GO:0007549)2.68158031
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67083707
73alpha-beta T cell differentiation (GO:0046632)2.65612070
74regulation of complement activation (GO:0030449)2.65399655
75neural tube formation (GO:0001841)2.64955919
76reverse cholesterol transport (GO:0043691)2.62266569
77negative regulation of fibrinolysis (GO:0051918)2.62248075
78microglial cell activation (GO:0001774)2.61679790
79T cell receptor signaling pathway (GO:0050852)2.60684975
80histone H3-K9 demethylation (GO:0033169)2.59362785
81negative regulation of B cell proliferation (GO:0030889)2.59262699
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.58474729
83negative regulation of cell killing (GO:0031342)2.58474729
84positive regulation of tolerance induction (GO:0002645)2.58369600
85positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57931113
86pre-miRNA processing (GO:0031054)2.56703317
87alpha-beta T cell activation (GO:0046631)2.56297735
88T cell differentiation (GO:0030217)2.55418998
89detection of molecule of bacterial origin (GO:0032490)2.54752588
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54388534
91protein-lipid complex subunit organization (GO:0071825)2.53729322
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53234489
93modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52930131
94positive regulation by organism of defense response of other organism involved in symbiotic interact2.52930131
95modulation by symbiont of host immune response (GO:0052553)2.52930131
96positive regulation by symbiont of host defense response (GO:0052509)2.52930131
97modulation by symbiont of host defense response (GO:0052031)2.52930131
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52930131
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.50794358
100negative regulation of B cell mediated immunity (GO:0002713)2.46777748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.73676342
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.33225957
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.45441499
4RUNX_20019798_ChIP-Seq_JUKART_Human3.00109051
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.88246563
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78824070
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67682805
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66810372
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.39273813
10MYB_26560356_Chip-Seq_TH2_Human2.29044854
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.28315689
12IGF1R_20145208_ChIP-Seq_DFB_Human2.19463387
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15327131
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.14648070
15ZNF274_21170338_ChIP-Seq_K562_Hela2.13696823
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.10890744
17IRF1_19129219_ChIP-ChIP_H3396_Human2.08440799
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06118888
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03024069
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95769596
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91913351
22GATA3_27048872_Chip-Seq_THYMUS_Human1.86639232
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86016278
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78410528
25RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.75278546
26MYB_26560356_Chip-Seq_TH1_Human1.74492932
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72634060
28GATA3_26560356_Chip-Seq_TH2_Human1.69816255
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69546572
30SCL_19346495_ChIP-Seq_HPC-7_Human1.65654455
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.65594569
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.62925729
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61462869
34VDR_22108803_ChIP-Seq_LS180_Human1.59216102
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.54079712
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.53307534
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.52154163
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51381509
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51058422
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48595742
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45339922
42CIITA_25753668_ChIP-Seq_RAJI_Human1.42949525
43CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42159388
44P300_19829295_ChIP-Seq_ESCs_Human1.39467349
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38876191
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33566183
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33111164
48EWS_26573619_Chip-Seq_HEK293_Human1.32411790
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30016402
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29095407
51VDR_24787735_ChIP-Seq_THP-1_Human1.27439200
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.26954799
53AR_21572438_ChIP-Seq_LNCaP_Human1.26655869
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26595804
55FUS_26573619_Chip-Seq_HEK293_Human1.26045633
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24423263
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.24320848
58SPI1_23547873_ChIP-Seq_NB4_Human1.24021847
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.19313930
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15180112
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15180112
62STAT3_23295773_ChIP-Seq_U87_Human1.14613752
63TAF15_26573619_Chip-Seq_HEK293_Human1.13573084
64FOXP3_21729870_ChIP-Seq_TREG_Human1.11737406
65BCAT_22108803_ChIP-Seq_LS180_Human1.10383184
66SALL4_22934838_ChIP-ChIP_CD34+_Human1.09105228
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06890272
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06716400
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.05970411
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05305828
71VDR_23849224_ChIP-Seq_CD4+_Human1.03574872
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03038686
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.02410048
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02006801
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.01654216
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01100087
77TCF4_23295773_ChIP-Seq_U87_Human1.00161212
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99906649
79ER_23166858_ChIP-Seq_MCF-7_Human0.99057560
80ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98815683
81FLI1_21867929_ChIP-Seq_TH2_Mouse0.98018645
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96749368
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.96436621
84GBX2_23144817_ChIP-Seq_PC3_Human0.96421399
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96310545
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95773867
87UTX_26944678_Chip-Seq_JUKART_Human0.95300929
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94054728
89P53_22387025_ChIP-Seq_ESCs_Mouse0.93797400
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.93521676
91E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93241691
92TCF4_22108803_ChIP-Seq_LS180_Human0.93213991
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91946411
94CMYC_18555785_Chip-Seq_ESCs_Mouse0.91714964
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91352363
96SPI1_23127762_ChIP-Seq_K562_Human0.90880211
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90747180
98HNF4A_19822575_ChIP-Seq_HepG2_Human0.90581990
99FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89995981
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89866530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.45418607
2MP0003122_maternal_imprinting3.34554939
3MP0002166_altered_tumor_susceptibility2.91255316
4MP0002396_abnormal_hematopoietic_system2.80225689
5MP0003724_increased_susceptibility_to2.73714910
6MP0001835_abnormal_antigen_presentation2.52720914
7MP0003763_abnormal_thymus_physiology2.52572083
8MP0001800_abnormal_humoral_immune2.52481634
9MP0002139_abnormal_hepatobiliary_system2.44541726
10MP0003183_abnormal_peptide_metabolism2.43141581
11MP0000685_abnormal_immune_system2.29973612
12MP0003787_abnormal_imprinting2.25323845
13MP0008877_abnormal_DNA_methylation2.15301331
14MP0008057_abnormal_DNA_replication2.14245251
15MP0003121_genomic_imprinting2.08120318
16MP0005671_abnormal_response_to2.03185144
17MP0000569_abnormal_digit_pigmentation2.02472995
18MP0002006_tumorigenesis2.01903334
19MP0006054_spinal_hemorrhage1.96000843
20MP0005085_abnormal_gallbladder_physiolo1.93617020
21MP0003252_abnormal_bile_duct1.93603318
22MP0005464_abnormal_platelet_physiology1.88181891
23MP0005220_abnormal_exocrine_pancreas1.80580109
24MP0002420_abnormal_adaptive_immunity1.77117666
25MP0000689_abnormal_spleen_morphology1.76460990
26MP0001666_abnormal_nutrient_absorption1.73914380
27MP0001819_abnormal_immune_cell1.73801096
28MP0002398_abnormal_bone_marrow1.70735127
29MP0000703_abnormal_thymus_morphology1.69106880
30MP0002723_abnormal_immune_serum1.67165150
31MP0003866_abnormal_defecation1.64916237
32MP0002452_abnormal_antigen_presenting1.63936592
33MP0003567_abnormal_fetal_cardiomyocyte1.61528046
34MP0003300_gastrointestinal_ulcer1.60094785
35MP0002405_respiratory_system_inflammati1.58621930
36MP0001790_abnormal_immune_system1.58411835
37MP0005387_immune_system_phenotype1.58411835
38MP0003172_abnormal_lysosome_physiology1.58370112
39MP0000716_abnormal_immune_system1.56687702
40MP0002722_abnormal_immune_system1.56425836
41MP0005000_abnormal_immune_tolerance1.49106304
42MP0003436_decreased_susceptibility_to1.48316609
43MP0002419_abnormal_innate_immunity1.44858792
44MP0005025_abnormal_response_to1.41932109
45MP0002138_abnormal_hepatobiliary_system1.41626513
46MP0004883_abnormal_blood_vessel1.40952049
47MP0005310_abnormal_salivary_gland1.40501639
48MP0003195_calcinosis1.39019092
49MP0010155_abnormal_intestine_physiology1.37794682
50MP0010329_abnormal_lipoprotein_level1.36835842
51MP0005075_abnormal_melanosome_morpholog1.34942525
52MP0001545_abnormal_hematopoietic_system1.25387346
53MP0005397_hematopoietic_system_phenotyp1.25387346
54MP0005365_abnormal_bile_salt1.21925601
55MP0002429_abnormal_blood_cell1.19525381
56MP0002132_abnormal_respiratory_system1.19105117
57MP0001984_abnormal_olfaction1.19006519
58MP0004381_abnormal_hair_follicle1.17659118
59MP0002933_joint_inflammation1.17567707
60MP0001915_intracranial_hemorrhage1.16564830
61MP0003303_peritoneal_inflammation1.15428235
62MP0002638_abnormal_pupillary_reflex1.14344582
63MP0009785_altered_susceptibility_to1.12852628
64MP0005167_abnormal_blood-brain_barrier1.12825320
65MP0005360_urolithiasis1.12618576
66MP0001986_abnormal_taste_sensitivity1.12511376
67MP0003878_abnormal_ear_physiology1.06892761
68MP0005377_hearing/vestibular/ear_phenot1.06892761
69MP0006292_abnormal_olfactory_placode1.06366727
70MP0004947_skin_inflammation1.03906867
71MP0001764_abnormal_homeostasis1.01756707
72MP0001845_abnormal_inflammatory_respons1.00694986
73MP0002163_abnormal_gland_morphology0.99813340
74MP0008995_early_reproductive_senescence0.95245848
75MP0009697_abnormal_copulation0.90797004
76MP0009278_abnormal_bone_marrow0.90296958
77MP0000465_gastrointestinal_hemorrhage0.89433915
78MP0008058_abnormal_DNA_repair0.88703662
79MP0001853_heart_inflammation0.87779867
80MP0006082_CNS_inflammation0.86703818
81MP0003136_yellow_coat_color0.86468513
82MP0006072_abnormal_retinal_apoptosis0.85766588
83MP0008469_abnormal_protein_level0.82227178
84MP0003868_abnormal_feces_composition0.77037547
85MP0004264_abnormal_extraembryonic_tissu0.75699793
86MP0001293_anophthalmia0.74206531
87MP0005174_abnormal_tail_pigmentation0.73848209
88MP0004043_abnormal_pH_regulation0.72818210
89MP0010386_abnormal_urinary_bladder0.72665257
90MP0003890_abnormal_embryonic-extraembry0.71447698
91MP0002019_abnormal_tumor_incidence0.69089487
92MP0008961_abnormal_basal_metabolism0.68539144
93MP0002277_abnormal_respiratory_mucosa0.68538702
94MP0003690_abnormal_glial_cell0.66853626
95MP0005379_endocrine/exocrine_gland_phen0.66029311
96MP0005551_abnormal_eye_electrophysiolog0.66028812
97MP0002148_abnormal_hypersensitivity_rea0.65790159
98MP0000604_amyloidosis0.65741113
99MP0005376_homeostasis/metabolism_phenot0.65168285
100MP0004808_abnormal_hematopoietic_stem0.64949381

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)4.30869134
2Abnormality of B cell number (HP:0010975)4.22646290
3Abnormality of the axillary hair (HP:0100134)4.19965969
4Abnormality of secondary sexual hair (HP:0009888)4.19965969
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.97166934
6Stomach cancer (HP:0012126)3.86645444
7Abnormality of T cell number (HP:0011839)3.45726544
8Thyroiditis (HP:0100646)3.44249186
9Severe combined immunodeficiency (HP:0004430)3.43445435
10Autoimmune thrombocytopenia (HP:0001973)3.39735224
11Colon cancer (HP:0003003)3.36941823
12Autoimmune hemolytic anemia (HP:0001890)3.22458150
13Fair hair (HP:0002286)3.18884526
14Recurrent fungal infections (HP:0002841)3.13177449
15Eosinophilia (HP:0001880)3.07687477
16T lymphocytopenia (HP:0005403)3.07482972
17Agammaglobulinemia (HP:0004432)3.05208892
18Abnormality of the prostate (HP:0008775)3.03783591
19Deep venous thrombosis (HP:0002625)2.96750873
20Papilledema (HP:0001085)2.90132580
21Gingival bleeding (HP:0000225)2.88671078
22IgM deficiency (HP:0002850)2.81710795
23B lymphocytopenia (HP:0010976)2.78825565
24Abnormality of eosinophils (HP:0001879)2.76607691
25Granulocytopenia (HP:0001913)2.76591924
26Hematochezia (HP:0002573)2.76404156
27Broad alveolar ridges (HP:0000187)2.71942794
28Combined immunodeficiency (HP:0005387)2.68633565
29Spontaneous abortion (HP:0005268)2.64198104
30Eczematoid dermatitis (HP:0000976)2.63369941
31Acanthocytosis (HP:0001927)2.62173485
32Leukocytosis (HP:0001974)2.58542967
33Diastasis recti (HP:0001540)2.57747653
34Chronic mucocutaneous candidiasis (HP:0002728)2.53448183
35Recurrent cutaneous fungal infections (HP:0011370)2.53448183
36Recurrent gram-negative bacterial infections (HP:0005420)2.51205598
37Recurrent viral infections (HP:0004429)2.50613811
38Abnormality of T cells (HP:0002843)2.48988501
39Meningitis (HP:0001287)2.47123291
40Hypobetalipoproteinemia (HP:0003563)2.44190051
41Generalized hypopigmentation of hair (HP:0011358)2.40512033
42Pustule (HP:0200039)2.33018222
43Recurrent bacterial skin infections (HP:0005406)2.30375397
44Prostate neoplasm (HP:0100787)2.29540785
45Pulmonary embolism (HP:0002204)2.28477858
46Prolonged partial thromboplastin time (HP:0003645)2.27519127
47Encephalitis (HP:0002383)2.25323501
48Abnormality of male internal genitalia (HP:0000022)2.21618298
49Hepatoblastoma (HP:0002884)2.21147567
50Thrombophlebitis (HP:0004418)2.19101123
51Recurrent skin infections (HP:0001581)2.17138118
52Complement deficiency (HP:0004431)2.15052761
53Renal cortical cysts (HP:0000803)2.13597469
54Supernumerary ribs (HP:0005815)2.12231546
55Viral hepatitis (HP:0006562)2.12121456
56Vasculitis (HP:0002633)2.11306021
57Recurrent bronchitis (HP:0002837)2.10066429
58Recurrent abscess formation (HP:0002722)2.08115789
59Abnormality of the common coagulation pathway (HP:0010990)2.06671341
60Epistaxis (HP:0000421)2.05199875
61Abnormal spermatogenesis (HP:0008669)2.04502648
62Increased IgM level (HP:0003496)2.03410175
63Prolonged bleeding time (HP:0003010)2.03165220
64Supernumerary bones of the axial skeleton (HP:0009144)1.99202950
65Broad palm (HP:0001169)1.98783072
66Supernumerary spleens (HP:0009799)1.97315898
67Joint hemorrhage (HP:0005261)1.95375720
68Bile duct proliferation (HP:0001408)1.94653747
69Abnormal biliary tract physiology (HP:0012439)1.94653747
70Abnormality of T cell physiology (HP:0011840)1.93338810
71Dry hair (HP:0011359)1.92525340
72IgG deficiency (HP:0004315)1.92005841
73Hyperglycinemia (HP:0002154)1.91909998
74Basal cell carcinoma (HP:0002671)1.91875056
75Colitis (HP:0002583)1.90943628
76Myositis (HP:0100614)1.90636157
77Abnormality of cells of the lymphoid lineage (HP:0012140)1.85879409
78Inflammation of the large intestine (HP:0002037)1.85338998
79Papillary thyroid carcinoma (HP:0002895)1.84697888
80Retrobulbar optic neuritis (HP:0100654)1.83454004
81Optic neuritis (HP:0100653)1.83454004
82Azoospermia (HP:0000027)1.83051185
83Hyperventilation (HP:0002883)1.82994979
84Carpal bone hypoplasia (HP:0001498)1.82131852
85Acute lymphatic leukemia (HP:0006721)1.81994767
86Hypoplasia of the thymus (HP:0000778)1.81422208
87Acute hepatic failure (HP:0006554)1.80887149
88Spontaneous hematomas (HP:0007420)1.79958836
89Chronic hepatic failure (HP:0100626)1.79913378
90Abnormality of the fingertips (HP:0001211)1.79263797
91Lymphopenia (HP:0001888)1.78376242
92Increased IgE level (HP:0003212)1.77017360
93Thrombocytosis (HP:0001894)1.76015234
94Pancreatic islet-cell hyperplasia (HP:0004510)1.75313595
95Elevated erythrocyte sedimentation rate (HP:0003565)1.74695763
96Enlarged kidneys (HP:0000105)1.74264583
97Recurrent sinusitis (HP:0011108)1.72844058
98Hypochromic anemia (HP:0001931)1.72077247
99Mediastinal lymphadenopathy (HP:0100721)1.71442268
100Abnormal hair whorl (HP:0010721)1.71034594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.00882290
2AKT33.48546401
3FRK3.03265308
4TEC2.71329811
5NLK2.53874892
6FGFR22.47267603
7FGFR32.46025376
8TAOK32.36432016
9ITK2.31159857
10CAMKK22.21661163
11BMPR1B2.10023767
12MAP4K12.03907981
13BRD42.03887740
14ACVR1B2.00464041
15RIPK41.95244629
16BTK1.90629351
17FES1.77424595
18FGFR41.59125927
19SYK1.48140198
20TXK1.47614402
21TNK21.44942262
22TYK21.43693781
23PASK1.36088632
24KIT1.32867079
25CAMK1D1.28468763
26SGK21.28013940
27YES11.26422759
28WNK11.20521854
29CDK121.19468137
30PIK3CA1.19019863
31BLK1.18130083
32LCK1.16307799
33LYN1.15944622
34CDK61.15817035
35CAMKK11.13553076
36TYRO31.11868445
37MKNK21.11391395
38MKNK11.09097547
39TGFBR11.06360024
40FGR1.00425826
41NUAK10.98312298
42SGK4940.95456095
43SGK2230.95456095
44HCK0.92417901
45GRK60.92214255
46CSF1R0.90221980
47MAP3K140.88781238
48ZAP700.88236912
49TNIK0.87878017
50ZAK0.87386181
51CDK40.84673804
52DYRK1B0.84206319
53SGK30.82723552
54CSK0.82230253
55CDK190.82114596
56MARK20.81777108
57JAK30.81430580
58FLT30.81393212
59TAF10.80833172
60MAP3K70.79553362
61VRK10.74227705
62WNK30.72228541
63CAMK1G0.72128315
64HIPK20.69791724
65UHMK10.64536792
66MAP3K130.62131304
67INSRR0.61767154
68PRKCQ0.61313944
69PRKAA20.60054762
70IKBKE0.59869885
71JAK20.59751722
72JAK10.59047624
73MAP2K30.54422193
74PIK3CG0.54126604
75IRAK10.53029641
76RIPK10.52459412
77TGFBR20.52021511
78CDC70.51674451
79DYRK1A0.49432280
80FGFR10.49408097
81SGK10.49195854
82CDC42BPA0.48801121
83BMPR20.48308401
84STK40.46815845
85IRAK40.46032999
86PIM10.45986615
87RPS6KA40.45500652
88PLK20.45322469
89ATR0.44787311
90CAMK40.41977929
91DYRK30.41795834
92BCR0.41284682
93PDK10.38839109
94ATM0.38765379
95FYN0.36628836
96CDK30.36454098
97ERBB20.34887355
98STK110.32014409
99WNK40.30658928
100CDK90.30646658

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.72474484
2Primary immunodeficiency_Homo sapiens_hsa053403.52483027
3Asthma_Homo sapiens_hsa053103.26898093
4Allograft rejection_Homo sapiens_hsa053303.00275894
5Autoimmune thyroid disease_Homo sapiens_hsa053202.91273218
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.81464540
7Graft-versus-host disease_Homo sapiens_hsa053322.79882874
8Type I diabetes mellitus_Homo sapiens_hsa049402.33365038
9Complement and coagulation cascades_Homo sapiens_hsa046102.31594997
10Leishmaniasis_Homo sapiens_hsa051402.27434060
11Systemic lupus erythematosus_Homo sapiens_hsa053222.21304235
12Vitamin digestion and absorption_Homo sapiens_hsa049771.94647117
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89144669
14Hematopoietic cell lineage_Homo sapiens_hsa046401.78198549
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72695430
16Antigen processing and presentation_Homo sapiens_hsa046121.62958294
17T cell receptor signaling pathway_Homo sapiens_hsa046601.59224762
18Non-homologous end-joining_Homo sapiens_hsa034501.56202042
19B cell receptor signaling pathway_Homo sapiens_hsa046621.50902509
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48378227
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46710016
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.43910471
23Retinol metabolism_Homo sapiens_hsa008301.40635337
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40397245
25ABC transporters_Homo sapiens_hsa020101.27315100
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.23488357
27Fat digestion and absorption_Homo sapiens_hsa049751.23223204
28Renin-angiotensin system_Homo sapiens_hsa046141.20312142
29Peroxisome_Homo sapiens_hsa041461.17863125
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15002069
31Chemical carcinogenesis_Homo sapiens_hsa052041.12688784
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09925429
33Herpes simplex infection_Homo sapiens_hsa051681.09727801
34Fatty acid degradation_Homo sapiens_hsa000711.08509825
35Ribosome_Homo sapiens_hsa030101.07275947
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05004661
37Linoleic acid metabolism_Homo sapiens_hsa005911.00924751
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99638891
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99090344
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98481547
41Fanconi anemia pathway_Homo sapiens_hsa034600.98099479
42Tuberculosis_Homo sapiens_hsa051520.97322936
43Propanoate metabolism_Homo sapiens_hsa006400.96283569
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94078970
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93879106
46Osteoclast differentiation_Homo sapiens_hsa043800.92216399
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91316083
48Non-small cell lung cancer_Homo sapiens_hsa052230.90792975
49Histidine metabolism_Homo sapiens_hsa003400.88245318
50Platelet activation_Homo sapiens_hsa046110.88223300
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.87635554
52Ether lipid metabolism_Homo sapiens_hsa005650.83536892
53Measles_Homo sapiens_hsa051620.83345821
54Toxoplasmosis_Homo sapiens_hsa051450.83233080
55Arachidonic acid metabolism_Homo sapiens_hsa005900.80121638
56Influenza A_Homo sapiens_hsa051640.79989730
57Acute myeloid leukemia_Homo sapiens_hsa052210.79371286
58Glycerolipid metabolism_Homo sapiens_hsa005610.78839591
59Prostate cancer_Homo sapiens_hsa052150.71799506
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71297407
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70351138
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.69474945
63Fatty acid biosynthesis_Homo sapiens_hsa000610.68165446
64Other glycan degradation_Homo sapiens_hsa005110.66781341
65Lysine degradation_Homo sapiens_hsa003100.66516448
66RNA degradation_Homo sapiens_hsa030180.64777646
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.63811052
68Viral myocarditis_Homo sapiens_hsa054160.63054323
69Spliceosome_Homo sapiens_hsa030400.62628508
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.62249088
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.59733954
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56123772
73Colorectal cancer_Homo sapiens_hsa052100.56025791
74Rheumatoid arthritis_Homo sapiens_hsa053230.55928282
75FoxO signaling pathway_Homo sapiens_hsa040680.55629843
76Regulation of autophagy_Homo sapiens_hsa041400.54308842
77Protein export_Homo sapiens_hsa030600.54281838
78Caffeine metabolism_Homo sapiens_hsa002320.53530886
79Nitrogen metabolism_Homo sapiens_hsa009100.51523039
80Butanoate metabolism_Homo sapiens_hsa006500.50214944
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48722332
82Alcoholism_Homo sapiens_hsa050340.48006995
83Pertussis_Homo sapiens_hsa051330.47045975
84Base excision repair_Homo sapiens_hsa034100.45377791
85Chemokine signaling pathway_Homo sapiens_hsa040620.44602635
86Choline metabolism in cancer_Homo sapiens_hsa052310.44065406
87Fatty acid metabolism_Homo sapiens_hsa012120.43577230
88Hepatitis B_Homo sapiens_hsa051610.39023967
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38967613
90mTOR signaling pathway_Homo sapiens_hsa041500.38252246
91Inositol phosphate metabolism_Homo sapiens_hsa005620.37789726
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37746782
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37499791
94Homologous recombination_Homo sapiens_hsa034400.36743700
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36024313
96mRNA surveillance pathway_Homo sapiens_hsa030150.35944868
97Starch and sucrose metabolism_Homo sapiens_hsa005000.33333600
98Notch signaling pathway_Homo sapiens_hsa043300.31563914
99Dorso-ventral axis formation_Homo sapiens_hsa043200.31401781
100Renin secretion_Homo sapiens_hsa049240.29258136

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