TXN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.90705012
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.80957092
3ATP synthesis coupled proton transport (GO:0015986)5.80957092
4proteasome assembly (GO:0043248)5.34586577
5ribosomal small subunit biogenesis (GO:0042274)4.91747381
6viral transcription (GO:0019083)4.73919941
7respiratory electron transport chain (GO:0022904)4.68014399
8translational termination (GO:0006415)4.54789928
9electron transport chain (GO:0022900)4.54690849
10chaperone-mediated protein transport (GO:0072321)4.50671573
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.49822134
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.47599087
13protein targeting to ER (GO:0045047)4.46723133
14cotranslational protein targeting to membrane (GO:0006613)4.43526889
15ribosomal large subunit biogenesis (GO:0042273)4.38321285
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.29247231
17protein localization to endoplasmic reticulum (GO:0070972)4.25397182
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.21645571
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.18258208
20negative regulation of ligase activity (GO:0051352)3.96554921
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.96554921
22ribosomal small subunit assembly (GO:0000028)3.93758416
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89595283
24maturation of SSU-rRNA (GO:0030490)3.86428608
25translational elongation (GO:0006414)3.84918516
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81605699
27regulation of cellular amino acid metabolic process (GO:0006521)3.73706725
28viral life cycle (GO:0019058)3.71277838
29regulation of chronic inflammatory response (GO:0002676)3.70149940
30translation (GO:0006412)3.69918792
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68725262
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.60847304
33regulation of vitamin D biosynthetic process (GO:0060556)3.58668040
34translational initiation (GO:0006413)3.55776836
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.53351017
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.53351017
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.51104548
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.51104548
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.51104548
40establishment of viral latency (GO:0019043)3.49280197
41purine nucleotide salvage (GO:0032261)3.49241655
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47114779
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.46930346
44cellular protein complex disassembly (GO:0043624)3.46586666
45establishment of integrated proviral latency (GO:0075713)3.46358617
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41700751
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.41700751
48antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.38320546
49regulation of mitochondrial translation (GO:0070129)3.34986249
50protein neddylation (GO:0045116)3.33908325
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.33659665
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31290451
53protein targeting to mitochondrion (GO:0006626)3.25465435
54ribonucleoprotein complex biogenesis (GO:0022613)3.22648737
55protein complex biogenesis (GO:0070271)3.21737733
56mitochondrial respiratory chain complex assembly (GO:0033108)3.21475068
57positive regulation of ligase activity (GO:0051351)3.19462887
58negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.16314146
59regulation of vitamin metabolic process (GO:0030656)3.12678696
60hydrogen ion transmembrane transport (GO:1902600)3.08928070
61regulation of T-helper 1 cell differentiation (GO:0045625)3.07381937
62rRNA modification (GO:0000154)3.04751142
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.04720075
64termination of RNA polymerase III transcription (GO:0006386)3.04720075
65ATP biosynthetic process (GO:0006754)3.02761097
66regulation of ubiquitin-protein transferase activity (GO:0051438)3.00041899
67cellular component biogenesis (GO:0044085)2.99959784
68protein targeting to membrane (GO:0006612)2.99389641
69establishment of protein localization to mitochondrion (GO:0072655)2.99210796
70protein localization to mitochondrion (GO:0070585)2.98533371
71purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95763836
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.93149033
73NADH dehydrogenase complex assembly (GO:0010257)2.93149033
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93149033
75regulation of ligase activity (GO:0051340)2.91443156
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89035554
77purine nucleobase biosynthetic process (GO:0009113)2.88915433
78oxidative phosphorylation (GO:0006119)2.88418138
79regulation of podosome assembly (GO:0071801)2.83695357
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82180634
81rRNA processing (GO:0006364)2.80257061
82negative regulation of protein ubiquitination (GO:0031397)2.80020302
83regulation of cellular amine metabolic process (GO:0033238)2.79923043
84DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78841944
85protein complex disassembly (GO:0043241)2.78834354
86nucleotide salvage (GO:0043173)2.77275466
87spliceosomal snRNP assembly (GO:0000387)2.74024144
88regulation of cytokine secretion involved in immune response (GO:0002739)2.73159844
89nucleoside salvage (GO:0043174)2.71983915
90macromolecular complex disassembly (GO:0032984)2.70173418
91cellular response to zinc ion (GO:0071294)2.68204574
92pteridine-containing compound biosynthetic process (GO:0042559)2.67828237
93mitochondrial transport (GO:0006839)2.66754512
94negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.65955578
95rRNA metabolic process (GO:0016072)2.65863209
96positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.65827819
97purine-containing compound salvage (GO:0043101)2.65225046
98purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.63951605
99purine nucleoside monophosphate biosynthetic process (GO:0009127)2.63951605
100folic acid-containing compound biosynthetic process (GO:0009396)2.63002066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.91798649
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.31268625
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.04242082
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.85349537
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67844715
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65214771
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.47541298
8E2F7_22180533_ChIP-Seq_HELA_Human3.19226587
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.17079654
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94458580
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88551269
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77308490
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74494468
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63401534
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59186065
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59075956
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56707783
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50775414
19DCP1A_22483619_ChIP-Seq_HELA_Human2.50698290
20ELK1_19687146_ChIP-ChIP_HELA_Human2.46431396
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36646446
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23156118
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19492624
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16502968
25VDR_23849224_ChIP-Seq_CD4+_Human2.15868673
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12935136
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.12557097
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12245898
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12224699
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09727399
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05032437
32* XRN2_22483619_ChIP-Seq_HELA_Human2.02511900
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.93247933
34FOXP3_21729870_ChIP-Seq_TREG_Human1.92778778
35TTF2_22483619_ChIP-Seq_HELA_Human1.86051574
36ZNF263_19887448_ChIP-Seq_K562_Human1.79059691
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77749835
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.77405502
39GABP_19822575_ChIP-Seq_HepG2_Human1.76387852
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74717296
41AR_21909140_ChIP-Seq_LNCAP_Human1.74681973
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71855754
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70819655
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69709873
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66824493
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60182371
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59875312
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56770229
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55421512
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54113283
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51853012
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50551558
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49417759
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49096290
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.46129923
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44822350
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44729597
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42182172
59TFEB_21752829_ChIP-Seq_HELA_Human1.41708167
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39016875
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.38408838
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34117524
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32828343
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32417695
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32099844
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.25941256
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25765156
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24611672
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23399425
70* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.21373392
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.18465066
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18151902
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16380055
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.14852353
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14342007
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.14052607
77ELF5_23300383_ChIP-Seq_T47D_Human1.12992903
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12130601
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12129581
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11543885
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11184644
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09859468
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05743650
84SPI1_23547873_ChIP-Seq_NB4_Human1.05595358
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04168424
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00480740
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99588412
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99049702
89MYC_18940864_ChIP-ChIP_HL60_Human0.98857553
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96100387
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95736538
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95413123
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89279238
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89236716
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87995050
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87059676
97KDM5A_27292631_Chip-Seq_BREAST_Human0.86929644
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83690355
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83522902
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82142505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis7.25476535
2MP0002148_abnormal_hypersensitivity_rea3.58674348
3MP0003186_abnormal_redox_activity3.39658612
4MP0003303_peritoneal_inflammation3.21999702
5MP0002139_abnormal_hepatobiliary_system3.04876692
6MP0009785_altered_susceptibility_to2.93395736
7MP0006082_CNS_inflammation2.88790124
8MP0009379_abnormal_foot_pigmentation2.78398752
9MP0001853_heart_inflammation2.68386654
10MP0005058_abnormal_lysosome_morphology2.50436754
11MP0004957_abnormal_blastocyst_morpholog2.24259149
12MP0003941_abnormal_skin_development2.23215014
13MP0000343_altered_response_to2.22153421
14MP0004510_myositis2.20877253
15MP0003693_abnormal_embryo_hatching2.18972514
16MP0001835_abnormal_antigen_presentation2.06929583
17MP0009764_decreased_sensitivity_to2.00755550
18MP0009697_abnormal_copulation1.94065483
19MP0006036_abnormal_mitochondrial_physio1.93056367
20MP0008007_abnormal_cellular_replicative1.79387194
21MP0008058_abnormal_DNA_repair1.73032421
22MP0003075_altered_response_to1.69129340
23MP0010094_abnormal_chromosome_stability1.67967813
24MP0003111_abnormal_nucleus_morphology1.66087381
25MP0005671_abnormal_response_to1.65653624
26MP0009840_abnormal_foam_cell1.63135231
27MP0003077_abnormal_cell_cycle1.62099098
28MP0005000_abnormal_immune_tolerance1.60681472
29MP0009333_abnormal_splenocyte_physiolog1.60193261
30MP0003453_abnormal_keratinocyte_physiol1.58927246
31MP0005025_abnormal_response_to1.56232588
32MP0003950_abnormal_plasma_membrane1.52934247
33MP0001790_abnormal_immune_system1.52213951
34MP0005387_immune_system_phenotype1.52213951
35MP0002877_abnormal_melanocyte_morpholog1.49169472
36MP0008469_abnormal_protein_level1.47593524
37MP0005451_abnormal_body_composition1.46057908
38MP0000858_altered_metastatic_potential1.45536247
39MP0003718_maternal_effect1.45158992
40MP0001542_abnormal_bone_strength1.44877446
41MP0005408_hypopigmentation1.44856693
42MP0003448_altered_tumor_morphology1.42652357
43MP0003436_decreased_susceptibility_to1.42417686
44MP0008875_abnormal_xenobiotic_pharmacok1.41567756
45MP0001845_abnormal_inflammatory_respons1.41520442
46MP0006054_spinal_hemorrhage1.40762375
47MP0002452_abnormal_antigen_presenting1.38852679
48MP0002419_abnormal_innate_immunity1.35448852
49MP0001764_abnormal_homeostasis1.33475158
50MP0000358_abnormal_cell_content/1.21622067
51MP0002723_abnormal_immune_serum1.20126036
52MP0006035_abnormal_mitochondrial_morpho1.19702550
53MP0008932_abnormal_embryonic_tissue1.18659764
54MP0008004_abnormal_stomach_pH1.13306279
55MP0005165_increased_susceptibility_to1.12767158
56MP0004947_skin_inflammation1.10230048
57MP0009765_abnormal_xenobiotic_induced1.08587476
58MP0003724_increased_susceptibility_to1.08524065
59MP0002254_reproductive_system_inflammat1.07828037
60MP0005166_decreased_susceptibility_to1.07406631
61MP0000685_abnormal_immune_system1.06958979
62MP0003191_abnormal_cellular_cholesterol1.06930313
63MP0010155_abnormal_intestine_physiology1.06531511
64MP0003786_premature_aging1.05701266
65MP0000490_abnormal_crypts_of1.03302055
66MP0001727_abnormal_embryo_implantation1.00910707
67MP0001800_abnormal_humoral_immune1.00499201
68MP0002332_abnormal_exercise_endurance1.00444063
69MP0005266_abnormal_metabolism1.00428534
70MP0009763_increased_sensitivity_to1.00084497
71MP0001881_abnormal_mammary_gland0.98717900
72MP0005319_abnormal_enzyme/_coenzyme0.97903534
73MP0001533_abnormal_skeleton_physiology0.96076266
74MP0005310_abnormal_salivary_gland0.95932824
75MP0002277_abnormal_respiratory_mucosa0.94422666
76MP0003656_abnormal_erythrocyte_physiolo0.94331669
77MP0002938_white_spotting0.93804417
78MP0003195_calcinosis0.92805259
79MP0002405_respiratory_system_inflammati0.91910430
80MP0001819_abnormal_immune_cell0.90824396
81MP0000313_abnormal_cell_death0.90077129
82MP0002420_abnormal_adaptive_immunity0.86500882
83MP0008873_increased_physiological_sensi0.86178534
84MP0005397_hematopoietic_system_phenotyp0.85715228
85MP0001545_abnormal_hematopoietic_system0.85715228
86MP0001216_abnormal_epidermal_layer0.84834409
87MP0010307_abnormal_tumor_latency0.82638833
88MP0002837_dystrophic_cardiac_calcinosis0.80747034
89MP0000350_abnormal_cell_proliferation0.79433851
90MP0002163_abnormal_gland_morphology0.79075124
91MP0002796_impaired_skin_barrier0.78242482
92MP0005636_abnormal_mineral_homeostasis0.75001377
93MP0002019_abnormal_tumor_incidence0.74167632
94MP0005584_abnormal_enzyme/coenzyme_acti0.72187300
95MP0005164_abnormal_response_to0.71712179
96MP0003315_abnormal_perineum_morphology0.70830687
97MP0002090_abnormal_vision0.69513416
98MP0000372_irregular_coat_pigmentation0.68747874
99MP0005501_abnormal_skin_physiology0.68683915
100MP0005376_homeostasis/metabolism_phenot0.67184776

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.48190105
2Abnormal mitochondria in muscle tissue (HP:0008316)5.18941658
3Mitochondrial inheritance (HP:0001427)4.92032707
4Increased hepatocellular lipid droplets (HP:0006565)4.81715060
5Acute encephalopathy (HP:0006846)4.71839407
6Increased CSF lactate (HP:0002490)4.46205680
7Progressive macrocephaly (HP:0004481)4.41225681
8Renal Fanconi syndrome (HP:0001994)4.41017041
9Lipid accumulation in hepatocytes (HP:0006561)4.39474312
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.14996818
11Decreased activity of mitochondrial respiratory chain (HP:0008972)4.14996818
12Hepatocellular necrosis (HP:0001404)4.14417525
13Abnormality of liposaccharide metabolism (HP:0010968)4.00066733
14Abnormality of glycosphingolipid metabolism (HP:0004343)4.00066733
15Abnormality of glycolipid metabolism (HP:0010969)4.00066733
16Abnormality of cells of the erythroid lineage (HP:0012130)3.96840925
173-Methylglutaconic aciduria (HP:0003535)3.86159772
18Hepatic necrosis (HP:0002605)3.82949862
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.81617502
20Macrocytic anemia (HP:0001972)3.79707741
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.67062294
22Increased intramyocellular lipid droplets (HP:0012240)3.66715925
23Cerebral edema (HP:0002181)3.61186324
24Abnormal number of erythroid precursors (HP:0012131)3.57207759
25Generalized aminoaciduria (HP:0002909)3.55635378
26Oral leukoplakia (HP:0002745)3.55488454
27Reticulocytopenia (HP:0001896)3.34173246
28Exertional dyspnea (HP:0002875)3.33546703
29Respiratory failure (HP:0002878)3.15173473
30Aplastic anemia (HP:0001915)3.08488913
31Vacuolated lymphocytes (HP:0001922)3.07472064
32Increased muscle lipid content (HP:0009058)3.06189032
33Lactic acidosis (HP:0003128)2.98379960
34Nausea (HP:0002018)2.97827886
35Type I transferrin isoform profile (HP:0003642)2.96915672
36Increased serum lactate (HP:0002151)2.92616266
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90078762
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89823117
39Congenital ichthyosiform erythroderma (HP:0007431)2.84903481
40Parakeratosis (HP:0001036)2.82488987
41Exercise intolerance (HP:0003546)2.81699688
42Respiratory difficulties (HP:0002880)2.81579886
43Amniotic constriction ring (HP:0009775)2.81463703
44Abnormality of placental membranes (HP:0011409)2.81463703
45Rough bone trabeculation (HP:0100670)2.78897166
46Reduced antithrombin III activity (HP:0001976)2.74661455
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.71010078
48Abnormality of renal resorption (HP:0011038)2.69901287
49Pallor (HP:0000980)2.69263345
50Sparse eyelashes (HP:0000653)2.59166803
51Congenital, generalized hypertrichosis (HP:0004540)2.56607139
52Abnormal trabecular bone morphology (HP:0100671)2.55979193
53Degeneration of anterior horn cells (HP:0002398)2.47312176
54Abnormality of the anterior horn cell (HP:0006802)2.47312176
55Leukodystrophy (HP:0002415)2.47013860
56Multiple enchondromatosis (HP:0005701)2.43930766
57Abnormality of methionine metabolism (HP:0010901)2.41490197
58Increased serum pyruvate (HP:0003542)2.41250611
59Nuclear cataract (HP:0100018)2.37917662
60Disinhibition (HP:0000734)2.36733549
61Systemic lupus erythematosus (HP:0002725)2.27856651
62Lethargy (HP:0001254)2.27256685
63Abnormality of glycolysis (HP:0004366)2.22245714
64Loss of speech (HP:0002371)2.21363968
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19702560
66Abnormal protein N-linked glycosylation (HP:0012347)2.19702560
67Abnormal protein glycosylation (HP:0012346)2.19702560
68Abnormal glycosylation (HP:0012345)2.19702560
69Hepatosplenomegaly (HP:0001433)2.13199473
70CNS demyelination (HP:0007305)2.10139281
71Mutism (HP:0002300)2.07859201
72Poor head control (HP:0002421)2.06520181
73Microvesicular hepatic steatosis (HP:0001414)2.02707599
74Optic disc pallor (HP:0000543)2.02238543
75Pancytopenia (HP:0001876)1.99494703
76Axonal loss (HP:0003447)1.99250862
77Neoplasm of head and neck (HP:0012288)1.93866406
78Esophageal neoplasm (HP:0100751)1.93866406
79Testicular atrophy (HP:0000029)1.92938335
80Hypertensive crisis (HP:0100735)1.92862038
81Glycosuria (HP:0003076)1.92361523
82Abnormality of urine glucose concentration (HP:0011016)1.92361523
83Increased serum ferritin (HP:0003281)1.91654975
84Autoimmune thrombocytopenia (HP:0001973)1.84732104
85Paralysis (HP:0003470)1.83648002
86Emotional lability (HP:0000712)1.81142125
87Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80886972
88X-linked dominant inheritance (HP:0001423)1.80711019
89Hyperphosphaturia (HP:0003109)1.79877653
90Prolonged neonatal jaundice (HP:0006579)1.78764323
91Increased IgM level (HP:0003496)1.78484756
92Progressive neurologic deterioration (HP:0002344)1.76879787
93Fasciculations (HP:0002380)1.76597267
94Vomiting (HP:0002013)1.71028693
95Methylmalonic aciduria (HP:0012120)1.69891075
96Petechiae (HP:0000967)1.68872472
97Posterior subcapsular cataract (HP:0007787)1.66157729
98Abnormality of macrophages (HP:0004311)1.65241875
99Cleft eyelid (HP:0000625)1.64901812
100Abnormalities of placenta or umbilical cord (HP:0001194)1.62951962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.03939670
2VRK24.04379541
3IRAK33.41178451
4PBK3.35561889
5BUB13.10180292
6MAP3K122.95682798
7MST42.95671380
8STK162.87224880
9PIM22.56266605
10GRK72.52192981
11EIF2AK12.34023732
12NEK12.08846087
13TESK11.92541068
14SRPK11.91462997
15CDC71.81785015
16NME11.80818367
17ABL21.79420355
18TAOK21.78503830
19EIF2AK31.72359492
20PAK41.63174438
21VRK11.62348917
22TESK21.48617943
23ARAF1.39520920
24MST1R1.38562588
25LIMK11.34329116
26PDK21.29097290
27TBK11.27527482
28MATK1.26158299
29DDR21.26039610
30ADRBK21.24941863
31IKBKB1.12113619
32TTK1.10459986
33ZAK1.07833319
34MOS1.05711522
35TLK10.98313902
36CLK10.97860730
37PLK30.95765214
38TAF10.93651268
39MAP3K140.93274218
40MAP3K110.90487385
41MYLK0.90222219
42BCKDK0.89016005
43WEE10.88784000
44PLK40.86023364
45MAP3K30.85995873
46EIF2AK20.85701307
47ERBB40.84906664
48SCYL20.84552280
49DAPK10.83798602
50PLK10.83794885
51DAPK30.83460162
52DYRK30.83057853
53EPHA20.79988407
54LATS20.78808513
55BMPR20.76034746
56AURKB0.75658802
57AURKA0.72270004
58RPS6KB20.68057713
59STK100.68028805
60ILK0.66979987
61CHEK20.66662882
62TYK20.63008376
63CSNK1G30.61977508
64CCNB10.60504794
65CSNK2A10.58679142
66MKNK10.57283225
67BRSK20.56674775
68MAP3K50.55701053
69IKBKE0.55285266
70ACVR1B0.54396520
71CSNK2A20.54052506
72TAOK10.53390293
73PAK10.49055471
74CHUK0.48401566
75TSSK60.47418393
76NUAK10.44739855
77IRAK40.42244665
78CDK80.41377917
79MAPKAPK50.39800582
80MAP3K80.39226173
81KDR0.39071416
82TGFBR20.38814497
83CSNK1A1L0.37305968
84RPS6KA50.37177030
85STK40.36933281
86CDK140.36061623
87CAMK2G0.35818580
88BRAF0.34446645
89BRSK10.34364393
90DYRK20.33487489
91PRKCI0.33483971
92CSNK1G20.33341544
93PIM10.32418411
94CDK11A0.30091105
95FGR0.29759910
96CDK150.28991302
97ALK0.28955315
98CDK180.28627938
99CSNK1G10.28126928
100PRKG20.27874180

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82366961
2Ribosome_Homo sapiens_hsa030104.59496933
3Oxidative phosphorylation_Homo sapiens_hsa001904.31026837
4Parkinsons disease_Homo sapiens_hsa050123.50447506
5Protein export_Homo sapiens_hsa030602.68557568
6DNA replication_Homo sapiens_hsa030302.48109298
7Huntingtons disease_Homo sapiens_hsa050162.41760088
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.39933336
9Alzheimers disease_Homo sapiens_hsa050102.38752053
10Mismatch repair_Homo sapiens_hsa034302.32433269
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15874262
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10875840
13RNA polymerase_Homo sapiens_hsa030202.06070851
14Homologous recombination_Homo sapiens_hsa034401.75969761
15Nucleotide excision repair_Homo sapiens_hsa034201.71456721
16Rheumatoid arthritis_Homo sapiens_hsa053231.64863183
17Folate biosynthesis_Homo sapiens_hsa007901.62547960
18Sulfur metabolism_Homo sapiens_hsa009201.62448873
19Pyrimidine metabolism_Homo sapiens_hsa002401.60778976
20Spliceosome_Homo sapiens_hsa030401.59010197
21Glutathione metabolism_Homo sapiens_hsa004801.51776725
22Asthma_Homo sapiens_hsa053101.47082411
23Allograft rejection_Homo sapiens_hsa053301.29055848
24Base excision repair_Homo sapiens_hsa034101.22081939
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.13305057
26Cardiac muscle contraction_Homo sapiens_hsa042601.12660758
27Collecting duct acid secretion_Homo sapiens_hsa049661.12533312
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11264144
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08970228
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05732304
31One carbon pool by folate_Homo sapiens_hsa006701.03388105
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00948160
33Legionellosis_Homo sapiens_hsa051340.99757180
34Intestinal immune network for IgA production_Homo sapiens_hsa046720.99648279
35Lysosome_Homo sapiens_hsa041420.96495026
36RNA transport_Homo sapiens_hsa030130.95561678
37NF-kappa B signaling pathway_Homo sapiens_hsa040640.95513870
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93159643
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92869083
40Autoimmune thyroid disease_Homo sapiens_hsa053200.92026529
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88677282
42African trypanosomiasis_Homo sapiens_hsa051430.84766021
43Other glycan degradation_Homo sapiens_hsa005110.84694748
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84634594
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84239493
46Basal transcription factors_Homo sapiens_hsa030220.83450183
47Purine metabolism_Homo sapiens_hsa002300.82787801
48Graft-versus-host disease_Homo sapiens_hsa053320.80426607
49Vibrio cholerae infection_Homo sapiens_hsa051100.79794495
50RNA degradation_Homo sapiens_hsa030180.79173283
51Salmonella infection_Homo sapiens_hsa051320.78691042
52Mineral absorption_Homo sapiens_hsa049780.78606356
53Epstein-Barr virus infection_Homo sapiens_hsa051690.78300921
54Fatty acid elongation_Homo sapiens_hsa000620.77927286
55Pertussis_Homo sapiens_hsa051330.77064126
56Type I diabetes mellitus_Homo sapiens_hsa049400.72070586
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.69716242
58Chemical carcinogenesis_Homo sapiens_hsa052040.69154910
59Pyruvate metabolism_Homo sapiens_hsa006200.67531615
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66359141
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65318198
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64449791
63Galactose metabolism_Homo sapiens_hsa000520.62953413
64Antigen processing and presentation_Homo sapiens_hsa046120.62700071
65Metabolic pathways_Homo sapiens_hsa011000.61680957
66Malaria_Homo sapiens_hsa051440.61428375
67Cell cycle_Homo sapiens_hsa041100.59386128
68Tryptophan metabolism_Homo sapiens_hsa003800.59074817
69Herpes simplex infection_Homo sapiens_hsa051680.59017509
70Pentose phosphate pathway_Homo sapiens_hsa000300.59017360
71Shigellosis_Homo sapiens_hsa051310.58495385
72Fanconi anemia pathway_Homo sapiens_hsa034600.58030692
73Carbon metabolism_Homo sapiens_hsa012000.55537170
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54735273
75Sulfur relay system_Homo sapiens_hsa041220.54018114
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52205989
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51853398
78Fructose and mannose metabolism_Homo sapiens_hsa000510.51539847
79Systemic lupus erythematosus_Homo sapiens_hsa053220.50025537
80Staphylococcus aureus infection_Homo sapiens_hsa051500.48718387
81TNF signaling pathway_Homo sapiens_hsa046680.48359214
82N-Glycan biosynthesis_Homo sapiens_hsa005100.47984622
83Phagosome_Homo sapiens_hsa041450.46516701
84Influenza A_Homo sapiens_hsa051640.46317394
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44824448
86Leishmaniasis_Homo sapiens_hsa051400.44365896
87Tuberculosis_Homo sapiens_hsa051520.44130714
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43501528
89Non-homologous end-joining_Homo sapiens_hsa034500.39256309
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38523219
91Steroid biosynthesis_Homo sapiens_hsa001000.38501485
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38469133
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37978766
94Tyrosine metabolism_Homo sapiens_hsa003500.37807215
95Peroxisome_Homo sapiens_hsa041460.36571763
96p53 signaling pathway_Homo sapiens_hsa041150.34309202
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34271890
98Biosynthesis of amino acids_Homo sapiens_hsa012300.33928667
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.33751607
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33693209

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