TXN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.75585964
2transcription from mitochondrial promoter (GO:0006390)8.64311642
3DNA deamination (GO:0045006)7.83744012
4replication fork processing (GO:0031297)7.28727097
5embryonic process involved in female pregnancy (GO:0060136)6.94882799
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.46983824
7positive regulation of protein homooligomerization (GO:0032464)6.42095046
8oxidative demethylation (GO:0070989)6.24487835
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.00846107
10ATP synthesis coupled proton transport (GO:0015986)5.91103674
11energy coupled proton transport, down electrochemical gradient (GO:0015985)5.91103674
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.87179388
13NADH dehydrogenase complex assembly (GO:0010257)5.87179388
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.87179388
15protein complex biogenesis (GO:0070271)5.75023631
16regulation of protein homooligomerization (GO:0032462)5.68149288
17regulation of integrin activation (GO:0033623)5.67436489
18mitochondrial DNA metabolic process (GO:0032042)5.59709086
19mitochondrial respiratory chain complex assembly (GO:0033108)5.38350196
20establishment of apical/basal cell polarity (GO:0035089)5.29859200
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.28212054
22somatic hypermutation of immunoglobulin genes (GO:0016446)5.11808674
23somatic diversification of immune receptors via somatic mutation (GO:0002566)5.11808674
24chaperone-mediated protein transport (GO:0072321)5.04095385
25viral mRNA export from host cell nucleus (GO:0046784)5.02440296
26respiratory electron transport chain (GO:0022904)4.98630290
27electron transport chain (GO:0022900)4.90683373
28glutamine family amino acid biosynthetic process (GO:0009084)4.85669896
29DNA strand renaturation (GO:0000733)4.85389130
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.79483947
31formation of translation preinitiation complex (GO:0001731)4.76919554
32mitotic G1 DNA damage checkpoint (GO:0031571)4.76593902
33poly(A)+ mRNA export from nucleus (GO:0016973)4.75614552
34negative regulation of fatty acid biosynthetic process (GO:0045717)4.55526304
35establishment of monopolar cell polarity (GO:0061162)4.53325228
36establishment or maintenance of monopolar cell polarity (GO:0061339)4.53325228
37cellular response to zinc ion (GO:0071294)4.49193982
38telomere maintenance via semi-conservative replication (GO:0032201)4.39704758
39negative regulation of JAK-STAT cascade (GO:0046426)4.32382077
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.28382653
41mRNA cleavage (GO:0006379)4.26135931
42mitotic G1/S transition checkpoint (GO:0044819)4.20992589
43negative regulation of cell cycle arrest (GO:0071157)4.20520271
44mitochondrial RNA metabolic process (GO:0000959)4.20148756
45regulation of translational fidelity (GO:0006450)4.14568330
46base-excision repair (GO:0006284)4.13802256
47respiratory chain complex IV assembly (GO:0008535)4.10311799
48embryonic placenta development (GO:0001892)4.09971580
49G1 DNA damage checkpoint (GO:0044783)4.08283463
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.00818475
51ribosomal small subunit assembly (GO:0000028)3.99129918
52DNA integration (GO:0015074)3.98247375
53sulfur amino acid catabolic process (GO:0000098)3.94263364
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.88158993
55regulation of mitochondrial translation (GO:0070129)3.87463451
56GDP-mannose metabolic process (GO:0019673)3.87128963
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.85757840
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.85053958
59proteasome assembly (GO:0043248)3.83087871
60cytochrome complex assembly (GO:0017004)3.82072537
61ATP biosynthetic process (GO:0006754)3.79060091
62viral transcription (GO:0019083)3.78926357
63protein targeting to mitochondrion (GO:0006626)3.78333229
64negative regulation of protein oligomerization (GO:0032460)3.75680769
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74563975
66base-excision repair, AP site formation (GO:0006285)3.72520133
67cellular response to ATP (GO:0071318)3.70689871
68maturation of 5.8S rRNA (GO:0000460)3.69396044
69spliceosomal tri-snRNP complex assembly (GO:0000244)3.67105819
70positive regulation of protein oligomerization (GO:0032461)3.66515776
71positive regulation of developmental pigmentation (GO:0048087)3.65524332
72rRNA modification (GO:0000154)3.60449416
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.59280096
74regulation of cellular amino acid metabolic process (GO:0006521)3.57567233
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.56211808
76double-strand break repair via nonhomologous end joining (GO:0006303)3.55388912
77non-recombinational repair (GO:0000726)3.55388912
78establishment of protein localization to mitochondrion (GO:0072655)3.54578568
79translational termination (GO:0006415)3.53694335
80telomere maintenance via recombination (GO:0000722)3.49048424
81DNA strand elongation involved in DNA replication (GO:0006271)3.48703531
82regulation of protein oligomerization (GO:0032459)3.46835742
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.45137748
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44987547
85DNA double-strand break processing (GO:0000729)3.44985540
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43875356
87mitochondrion morphogenesis (GO:0070584)3.42613386
88water-soluble vitamin biosynthetic process (GO:0042364)3.42343738
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.41180969
90dosage compensation (GO:0007549)3.40374939
91termination of RNA polymerase II transcription (GO:0006369)3.40270142
92cotranslational protein targeting to membrane (GO:0006613)3.39837688
93termination of RNA polymerase III transcription (GO:0006386)3.39738951
94transcription elongation from RNA polymerase III promoter (GO:0006385)3.39738951
95protein localization to mitochondrion (GO:0070585)3.38829147
96cullin deneddylation (GO:0010388)3.37396453
97protein targeting to ER (GO:0045047)3.36590108
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36347348
99negative regulation of ligase activity (GO:0051352)3.36347348
100oxidative phosphorylation (GO:0006119)3.35171112
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34732201
102negative regulation of mRNA processing (GO:0050686)3.33817131
103mitochondrial DNA replication (GO:0006264)3.33355257
104signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32934613
105signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32934613
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32934613
107positive regulation of DNA repair (GO:0045739)3.32097753
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31535364
109intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31535364
110negative regulation of Ras GTPase activity (GO:0034261)3.31085966
111positive regulation by host of viral transcription (GO:0043923)3.29264842
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29072880
113protein localization to endoplasmic reticulum (GO:0070972)3.28798707
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28531954
115DNA strand elongation (GO:0022616)3.28452864
116translational elongation (GO:0006414)3.28238795
117cellular component biogenesis (GO:0044085)3.27901390
118pyrimidine nucleotide catabolic process (GO:0006244)3.26890304
119ribosomal small subunit biogenesis (GO:0042274)3.25692685
120maturation of SSU-rRNA (GO:0030490)3.24978137
121exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23165285
122signal transduction involved in DNA integrity checkpoint (GO:0072401)3.23117380
123signal transduction involved in DNA damage checkpoint (GO:0072422)3.23117380
124inner mitochondrial membrane organization (GO:0007007)3.22894437
125hydrogen ion transmembrane transport (GO:1902600)3.22682788
126alkaloid metabolic process (GO:0009820)3.20574404
127ribonucleoside triphosphate biosynthetic process (GO:0009201)3.20415098
128signal transduction involved in cell cycle checkpoint (GO:0072395)3.18766717
129apoptotic process involved in morphogenesis (GO:0060561)3.18713591
130establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17991025
131embryonic camera-type eye development (GO:0031076)3.17433828
132DNA topological change (GO:0006265)3.17387475
133spliceosomal snRNP assembly (GO:0000387)3.17147826
134glial cell migration (GO:0008347)3.14557035
135DNA ligation (GO:0006266)3.13228896
136protein deneddylation (GO:0000338)3.13172724
137kinetochore assembly (GO:0051382)3.12997989
138translation (GO:0006412)3.12335846
139meiotic chromosome segregation (GO:0045132)3.10539753
140very-low-density lipoprotein particle assembly (GO:0034379)3.10501407
141mannosylation (GO:0097502)3.10371381
142anatomical structure regression (GO:0060033)3.08976961
143DNA demethylation (GO:0080111)3.08525810
144negative regulation of heart rate (GO:0010459)3.08378057
145ribosomal large subunit biogenesis (GO:0042273)3.06989880
146nuclear envelope reassembly (GO:0031468)3.06479456
147mitotic nuclear envelope reassembly (GO:0007084)3.06479456
148face development (GO:0060324)3.05416982
149mitochondrial transport (GO:0006839)3.03412654
150pseudouridine synthesis (GO:0001522)3.03363438
151nucleoside triphosphate biosynthetic process (GO:0009142)3.02528118
152positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01838360
153intracellular protein transmembrane import (GO:0044743)3.00930986
154convergent extension (GO:0060026)3.00889420
155heme biosynthetic process (GO:0006783)2.99353256
156ubiquinone biosynthetic process (GO:0006744)2.99029951
157positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97071226
158positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97071226
159positive regulation of mitotic sister chromatid separation (GO:1901970)2.97071226
160negative regulation of telomerase activity (GO:0051974)2.95227140
161histone H4-K12 acetylation (GO:0043983)2.95128083
162trophectodermal cell differentiation (GO:0001829)2.94216294
163negative regulation of RNA splicing (GO:0033119)2.94206600
164regulation of sister chromatid cohesion (GO:0007063)2.93097012
165regulation of mitochondrial depolarization (GO:0051900)2.92759543
166labyrinthine layer development (GO:0060711)2.91761105
167aerobic respiration (GO:0009060)2.91516859
168glycine metabolic process (GO:0006544)2.90648807
169positive regulation of ligase activity (GO:0051351)2.89958230
170branching involved in labyrinthine layer morphogenesis (GO:0060670)2.89810104
171regulation of double-strand break repair (GO:2000779)2.89455334
172negative regulation of appetite (GO:0032099)2.89447465
173negative regulation of response to food (GO:0032096)2.89447465
174proton transport (GO:0015992)2.89066914
175tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88017979
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88017979
177telomere maintenance via telomere lengthening (GO:0010833)2.87700350
178protein neddylation (GO:0045116)2.86829365
179positive regulation of mitochondrial fission (GO:0090141)2.86302817
180purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.84274540
181purine nucleoside monophosphate biosynthetic process (GO:0009127)2.84274540
182GTP biosynthetic process (GO:0006183)2.83858912
183mitochondrial fusion (GO:0008053)2.83351850
184hydrogen transport (GO:0006818)2.82560791
185translational initiation (GO:0006413)2.82395742
186heme metabolic process (GO:0042168)2.81876855
187viral life cycle (GO:0019058)2.81853447
188regulation of ubiquitin-protein transferase activity (GO:0051438)2.81073182
189aldehyde catabolic process (GO:0046185)2.78511644
190pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.76793117
191tetrapyrrole biosynthetic process (GO:0033014)2.75978394
192proline biosynthetic process (GO:0006561)11.1819673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.84096888
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.41405158
3CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17638313
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12234317
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.10652223
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06185062
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03333717
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.77850366
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72000143
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.64819453
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.63935619
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47512116
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45296919
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37962706
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31632022
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31632022
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31632022
18VDR_21846776_ChIP-Seq_THP-1_Human2.29966861
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28952925
20FOXP3_21729870_ChIP-Seq_TREG_Human2.22935273
21* VDR_23849224_ChIP-Seq_CD4+_Human2.20614084
22* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18000994
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.15703655
24E2F7_22180533_ChIP-Seq_HELA_Human2.04127746
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02016522
26STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01695944
27KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.01492503
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97489961
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95164640
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.92763673
31LXR_22292898_ChIP-Seq_THP-1_Human1.92447092
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91672282
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.91415521
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.80315702
35POU5F1_16518401_ChIP-PET_MESCs_Mouse1.77825935
36* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.77664765
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77504636
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74628192
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.74397870
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73323165
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72573610
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.70269341
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67688719
44MYC_18940864_ChIP-ChIP_HL60_Human1.67561390
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61240774
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59703699
47MYC_22102868_ChIP-Seq_BL_Human1.59511616
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.57470908
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.57133669
50* RXR_22158963_ChIP-Seq_LIVER_Mouse1.55482064
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.54313426
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.53909729
53ELK1_19687146_ChIP-ChIP_HELA_Human1.53655289
54DCP1A_22483619_ChIP-Seq_HELA_Human1.52009820
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.51640936
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50593921
57* GABP_19822575_ChIP-Seq_HepG2_Human1.48341302
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46865920
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46846498
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46597078
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45914651
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42864410
63ZNF263_19887448_ChIP-Seq_K562_Human1.40275611
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40001813
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39051326
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37703782
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37295469
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36475553
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36038904
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35911731
71RACK7_27058665_Chip-Seq_MCF-7_Human1.35697452
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35193113
73* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35102990
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34484145
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33198154
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32909880
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.32322235
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32050362
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31834948
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31755197
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29346765
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.28787481
83CIITA_25753668_ChIP-Seq_RAJI_Human1.27878180
84POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27746170
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26887858
86* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26586040
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26556062
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24319068
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24279894
90ETS1_21867929_ChIP-Seq_TH2_Mouse1.23050944
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22866120
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22295842
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21435372
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20914632
95SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20742912
96RARB_24833708_ChIP-Seq_LIVER_Mouse1.20453458
97* XRN2_22483619_ChIP-Seq_HELA_Human1.20404052
98OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20288151
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19382649
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19291229
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18131776
102* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17541157
103KDM5A_27292631_Chip-Seq_BREAST_Human1.17313098
104SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17096159
105SRF_21415370_ChIP-Seq_HL-1_Mouse1.16499362
106CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15179256
107FOXP1_21924763_ChIP-Seq_HESCs_Human1.14523879
108* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14311579
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14137252
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13686023
111RARA_24833708_ChIP-Seq_LIVER_Mouse1.12952332
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12448147
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11253957
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10462516
115TTF2_22483619_ChIP-Seq_HELA_Human1.10366964
116BCOR_27268052_Chip-Seq_Bcells_Human1.09108589
117ZNF274_21170338_ChIP-Seq_K562_Hela1.08578610
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.08487507
119PHF8_20622854_ChIP-Seq_HELA_Human1.07864618
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07410628
121NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07267475
122ELK3_25401928_ChIP-Seq_HUVEC_Human1.06912748
123* EST1_17652178_ChIP-ChIP_JURKAT_Human1.06810571
124BCL6_27268052_Chip-Seq_Bcells_Human1.06686018
125* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04997880
126SPI1_26923725_Chip-Seq_HPCs_Mouse1.04996740
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04950031
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04748953
129SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04318555
130ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04125388
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03984324
132* GABP_17652178_ChIP-ChIP_JURKAT_Human1.03965580
133EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03815708
134NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03411394
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01628743
136ELF1_20517297_ChIP-Seq_JURKAT_Human1.00529796
137CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98034935
138CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97930361
139SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97221828
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97062781
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96404800
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96127145
143RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94298638
144CTCF_20526341_ChIP-Seq_ESCs_Human0.93204208
145E2F1_20622854_ChIP-Seq_HELA_Human0.92451100
146ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89725950
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.87074608
148CTCF_26484167_Chip-Seq_Bcells_Mouse0.86680147
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85250002
150NANOG_20526341_ChIP-Seq_ESCs_Human0.84255982
151* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83221246
152* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83099465
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82053363
154P68_20966046_ChIP-Seq_HELA_Human0.81532225
155PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81316577
156ERA_21632823_ChIP-Seq_H3396_Human0.80450706
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79917472
158TAF2_19829295_ChIP-Seq_ESCs_Human0.76597590
159ERG_20517297_ChIP-Seq_VCAP_Human0.75564959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.99154376
2MP0005171_absent_coat_pigmentation4.25535911
3MP0009278_abnormal_bone_marrow4.10399555
4MP0005670_abnormal_white_adipose3.76090580
5MP0010030_abnormal_orbit_morphology3.59499861
6MP0004233_abnormal_muscle_weight3.39620758
7* MP0006036_abnormal_mitochondrial_physio2.78425495
8MP0002009_preneoplasia2.66180726
9MP0001545_abnormal_hematopoietic_system2.49423692
10MP0005397_hematopoietic_system_phenotyp2.49423692
11MP0005085_abnormal_gallbladder_physiolo2.46633975
12MP0008995_early_reproductive_senescence2.44271830
13MP0009379_abnormal_foot_pigmentation2.42755680
14MP0010094_abnormal_chromosome_stability2.40696541
15MP0000372_irregular_coat_pigmentation2.37518979
16MP0004147_increased_porphyrin_level2.29834297
17MP0002102_abnormal_ear_morphology2.22760995
18MP0005365_abnormal_bile_salt2.21694859
19MP0005646_abnormal_pituitary_gland2.21300896
20MP0004957_abnormal_blastocyst_morpholog2.21126196
21MP0003806_abnormal_nucleotide_metabolis2.19412061
22MP0006035_abnormal_mitochondrial_morpho2.18863344
23MP0003786_premature_aging2.10950174
24MP0006292_abnormal_olfactory_placode2.09203064
25MP0001485_abnormal_pinna_reflex1.96341489
26MP0003890_abnormal_embryonic-extraembry1.89771366
27MP0001529_abnormal_vocalization1.87021265
28MP0004133_heterotaxia1.86645164
29MP0003011_delayed_dark_adaptation1.86273646
30MP0000049_abnormal_middle_ear1.85910035
31MP0005174_abnormal_tail_pigmentation1.85685150
32MP0002653_abnormal_ependyma_morphology1.84674259
33MP0003315_abnormal_perineum_morphology1.84120018
34MP0005367_renal/urinary_system_phenotyp1.83373874
35MP0000516_abnormal_urinary_system1.83373874
36MP0008875_abnormal_xenobiotic_pharmacok1.75909263
37MP0002249_abnormal_larynx_morphology1.73704496
38MP0003656_abnormal_erythrocyte_physiolo1.72544171
39MP0002269_muscular_atrophy1.71148346
40MP0002837_dystrophic_cardiac_calcinosis1.71144608
41MP0000013_abnormal_adipose_tissue1.68810852
42MP0003119_abnormal_digestive_system1.66714641
43MP0008058_abnormal_DNA_repair1.65867928
44MP0002160_abnormal_reproductive_system1.64227461
45MP0003111_abnormal_nucleus_morphology1.63730310
46MP0005075_abnormal_melanosome_morpholog1.62575855
47MP0000490_abnormal_crypts_of1.57113642
48MP0003693_abnormal_embryo_hatching1.56666018
49MP0003136_yellow_coat_color1.56594659
50MP0002938_white_spotting1.55521373
51MP0006072_abnormal_retinal_apoptosis1.54073253
52MP0003283_abnormal_digestive_organ1.53508385
53MP0008872_abnormal_physiological_respon1.51321100
54MP0003453_abnormal_keratinocyte_physiol1.51135514
55MP0001905_abnormal_dopamine_level1.50175687
56MP0008932_abnormal_embryonic_tissue1.50135226
57MP0008789_abnormal_olfactory_epithelium1.50031819
58MP0002282_abnormal_trachea_morphology1.48797636
59MP0001968_abnormal_touch/_nociception1.48376879
60MP0005058_abnormal_lysosome_morphology1.47552957
61MP0002086_abnormal_extraembryonic_tissu1.47517283
62MP0004145_abnormal_muscle_electrophysio1.46059878
63MP0003567_abnormal_fetal_cardiomyocyte1.44120183
64MP0003172_abnormal_lysosome_physiology1.43033341
65MP0001661_extended_life_span1.42788068
66MP0002736_abnormal_nociception_after1.41404105
67MP0010352_gastrointestinal_tract_polyps1.39524153
68MP0005266_abnormal_metabolism1.38919725
69MP0000579_abnormal_nail_morphology1.34963201
70MP0000639_abnormal_adrenal_gland1.33863710
71MP0001293_anophthalmia1.33107935
72MP0008877_abnormal_DNA_methylation1.32586326
73MP0000371_diluted_coat_color1.31532626
74MP0005330_cardiomyopathy1.30979939
75* MP0001697_abnormal_embryo_size1.30822260
76MP0003077_abnormal_cell_cycle1.27318555
77MP0003718_maternal_effect1.25896193
78MP0001986_abnormal_taste_sensitivity1.24466073
79MP0002084_abnormal_developmental_patter1.23726716
80MP0002277_abnormal_respiratory_mucosa1.23382925
81MP0004197_abnormal_fetal_growth/weight/1.19149501
82MP0008007_abnormal_cellular_replicative1.14627990
83MP0000470_abnormal_stomach_morphology1.14496471
84MP0003828_pulmonary_edema1.14375389
85MP0001672_abnormal_embryogenesis/_devel1.12831605
86MP0005380_embryogenesis_phenotype1.12831605
87MP0005389_reproductive_system_phenotype1.11607330
88MP0003646_muscle_fatigue1.10912815
89MP0005076_abnormal_cell_differentiation1.08892804
90MP0003137_abnormal_impulse_conducting1.08854733
91MP0000015_abnormal_ear_pigmentation1.08825029
92MP0002019_abnormal_tumor_incidence1.07929266
93MP0005084_abnormal_gallbladder_morpholo1.07251247
94* MP0002085_abnormal_embryonic_tissue1.06953575
95MP0005636_abnormal_mineral_homeostasis1.05261798
96MP0002751_abnormal_autonomic_nervous1.04908143
97MP0002139_abnormal_hepatobiliary_system1.04902989
98MP0004019_abnormal_vitamin_homeostasis1.04774184
99MP0002332_abnormal_exercise_endurance1.03678376
100MP0005360_urolithiasis1.03401180
101MP0002095_abnormal_skin_pigmentation1.02821624
102MP0002822_catalepsy1.01308023
103MP0002876_abnormal_thyroid_physiology1.01072348
104MP0003195_calcinosis1.00825874
105MP0002796_impaired_skin_barrier1.00712308
106MP0003938_abnormal_ear_development1.00503257
107MP0005551_abnormal_eye_electrophysiolog1.00315914
108MP0009765_abnormal_xenobiotic_induced0.99590997
109MP0001730_embryonic_growth_arrest0.98280752
110MP0005253_abnormal_eye_physiology0.96900353
111MP0002080_prenatal_lethality0.95822142
112MP0000685_abnormal_immune_system0.95737316
113MP0009115_abnormal_fat_cell0.94694256
114MP0005377_hearing/vestibular/ear_phenot0.94676638
115MP0003878_abnormal_ear_physiology0.94676638
116MP0002111_abnormal_tail_morphology0.93646466
117MP0000631_abnormal_neuroendocrine_gland0.92460259
118MP0000350_abnormal_cell_proliferation0.91182263
119MP0002210_abnormal_sex_determination0.88565634
120MP0010630_abnormal_cardiac_muscle0.88191435
121MP0003984_embryonic_growth_retardation0.87902395
122MP0000358_abnormal_cell_content/0.87420403
123MP0000751_myopathy0.85371377
124MP0005332_abnormal_amino_acid0.84891402
125MP0000749_muscle_degeneration0.84547843
126MP0009333_abnormal_splenocyte_physiolog0.84319654
127MP0005499_abnormal_olfactory_system0.84143157
128MP0005394_taste/olfaction_phenotype0.84143157
129MP0001340_abnormal_eyelid_morphology0.83652298
130MP0001764_abnormal_homeostasis0.83622966
131MP0002088_abnormal_embryonic_growth/wei0.82895612
132MP0000462_abnormal_digestive_system0.81884232
133MP0009053_abnormal_anal_canal0.80168729
134MP0004885_abnormal_endolymph0.79211999
135MP0002132_abnormal_respiratory_system0.78649383
136MP0004264_abnormal_extraembryonic_tissu0.78525774
137MP0003186_abnormal_redox_activity0.77910163
138MP0002234_abnormal_pharynx_morphology0.77647204
139MP0005376_homeostasis/metabolism_phenot0.77380878
140MP0002405_respiratory_system_inflammati0.77279700
141MP0002932_abnormal_joint_morphology0.77208668
142MP0005319_abnormal_enzyme/_coenzyme0.77038424
143MP0009840_abnormal_foam_cell0.76707788
144MP0002970_abnormal_white_adipose0.75787882
145MP0001145_abnormal_male_reproductive0.75435782
146MP0000653_abnormal_sex_gland0.75086772
147MP0000026_abnormal_inner_ear0.74304213
148MP0002075_abnormal_coat/hair_pigmentati0.73970662
149MP0001963_abnormal_hearing_physiology0.73602475
150MP0005501_abnormal_skin_physiology0.73212227
151MP0001756_abnormal_urination0.71249569
152MP0003221_abnormal_cardiomyocyte_apopto0.71232298
153MP0004142_abnormal_muscle_tone0.71189519
154MP0001929_abnormal_gametogenesis0.70931385
155MP0001324_abnormal_eye_pigmentation0.70789334
156MP0005645_abnormal_hypothalamus_physiol0.69751771
157MP0002272_abnormal_nervous_system0.69749566
158MP0008873_increased_physiological_sensi0.69600734
159MP0002060_abnormal_skin_morphology0.69033495
160MP0006276_abnormal_autonomic_nervous0.68904709
161MP0000762_abnormal_tongue_morphology0.68815029
162MP0000678_abnormal_parathyroid_gland0.68218492
163MP0006082_CNS_inflammation0.67524313
164MP0000689_abnormal_spleen_morphology0.65561308
165MP0003638_abnormal_response/metabolism_0.65488332
166MP0002735_abnormal_chemical_nociception0.65303259
167MP0000609_abnormal_liver_physiology0.64770940

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.27805147
2Abnormal mitochondria in muscle tissue (HP:0008316)5.97521892
3Acute encephalopathy (HP:0006846)5.60424597
4Mitochondrial inheritance (HP:0001427)5.33565285
5Progressive macrocephaly (HP:0004481)5.17503473
6Pustule (HP:0200039)5.09110569
7Increased IgM level (HP:0003496)5.07548186
8Rib fusion (HP:0000902)5.06579668
9Concave nail (HP:0001598)5.00721759
10Annular pancreas (HP:0001734)4.81171717
11Increased CSF lactate (HP:0002490)4.74992947
12Rectovaginal fistula (HP:0000143)4.61795871
13Rectal fistula (HP:0100590)4.61795871
14Hepatocellular necrosis (HP:0001404)4.59032617
15Facial hemangioma (HP:0000329)4.55275780
16Poikiloderma (HP:0001029)4.50919650
17Alopecia of scalp (HP:0002293)4.44803431
18Hepatic necrosis (HP:0002605)4.31083608
19Hypochromic microcytic anemia (HP:0004840)4.30579240
20Turricephaly (HP:0000262)4.27286708
21Tongue fasciculations (HP:0001308)4.22815335
22Vaginal fistula (HP:0004320)4.21296698
23Intestinal fistula (HP:0100819)4.07828613
24Cerebral edema (HP:0002181)4.05243884
25Abnormal hemoglobin (HP:0011902)4.01256136
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.99527651
27Muscle fibrillation (HP:0010546)3.96765269
28Ulnar bowing (HP:0003031)3.72234431
29Short 1st metacarpal (HP:0010034)3.65700755
30Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.65700755
31Reticulocytopenia (HP:0001896)3.59784699
32Male infertility (HP:0003251)3.46656526
33Coronal craniosynostosis (HP:0004440)3.42246254
34Increased hepatocellular lipid droplets (HP:0006565)3.41506653
35Lactic acidosis (HP:0003128)3.39711010
36Orthostatic hypotension (HP:0001278)3.35462541
37Abnormal number of erythroid precursors (HP:0012131)3.31125484
38Renal Fanconi syndrome (HP:0001994)3.28091577
39Short humerus (HP:0005792)3.26030558
40Abnormality of male internal genitalia (HP:0000022)3.25378149
41Abnormality of the 1st metacarpal (HP:0010009)3.25213656
42Lipid accumulation in hepatocytes (HP:0006561)3.24861163
43Aplasia/hypoplasia of the humerus (HP:0006507)3.22564607
44Increased intramyocellular lipid droplets (HP:0012240)3.21544110
45Large for gestational age (HP:0001520)3.17701747
46Diaphragmatic weakness (HP:0009113)3.17302790
47Intestinal atresia (HP:0011100)3.16127194
48Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10735250
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10735250
50Urinary glycosaminoglycan excretion (HP:0003541)3.10227635
51Mucopolysacchariduria (HP:0008155)3.10227635
52Vertebral hypoplasia (HP:0008417)3.09045442
53Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.09045442
54Stenosis of the external auditory canal (HP:0000402)3.06610671
55Pancreatic islet-cell hyperplasia (HP:0004510)3.06088561
56Exercise intolerance (HP:0003546)3.03340883
57Polycythemia (HP:0001901)3.03090617
58Respiratory failure (HP:0002878)3.02068514
59Abnormality of cells of the erythroid lineage (HP:0012130)3.01879496
60Optic disc pallor (HP:0000543)2.98896789
61Absent thumb (HP:0009777)2.97681905
62Congenital hip dislocation (HP:0001374)2.96851872
63Increased serum lactate (HP:0002151)2.96339829
64Squamous cell carcinoma (HP:0002860)2.92025964
65Absent radius (HP:0003974)2.88438732
66Abnormality of the aortic arch (HP:0012303)2.87657816
67Albinism (HP:0001022)2.87394155
68Short chin (HP:0000331)2.84710614
69Broad alveolar ridges (HP:0000187)2.83999440
70Dysautonomia (HP:0002459)2.83317822
71Increased muscle lipid content (HP:0009058)2.81827150
72Premature skin wrinkling (HP:0100678)2.81684331
73Growth hormone excess (HP:0000845)2.81400966
74Hypokinesia (HP:0002375)2.76779097
75Abnormality of polysaccharide metabolism (HP:0011012)2.76200987
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.76200987
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.76200987
78Anteriorly placed anus (HP:0001545)2.72149867
79Dysostosis multiplex (HP:0000943)2.71507573
80Joint stiffness (HP:0001387)2.70151791
81Absent forearm bone (HP:0003953)2.68619985
82Aplasia involving forearm bones (HP:0009822)2.68619985
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68286663
843-Methylglutaconic aciduria (HP:0003535)2.67840004
85Asymmetric septal hypertrophy (HP:0001670)2.67710665
86Leukodystrophy (HP:0002415)2.66359965
87Premature graying of hair (HP:0002216)2.63700009
88Hypochromic anemia (HP:0001931)2.63089316
89Patellar aplasia (HP:0006443)2.60593147
90Lethargy (HP:0001254)2.59626025
91Carpal bone hypoplasia (HP:0001498)2.57990915
92Hypotrichosis (HP:0001006)2.57721134
93Exertional dyspnea (HP:0002875)2.55714003
94Selective tooth agenesis (HP:0001592)2.54541364
95Basal cell carcinoma (HP:0002671)2.54510128
96Alacrima (HP:0000522)2.53274380
97Muscle fiber atrophy (HP:0100295)2.49803529
98Redundant skin (HP:0001582)2.47290853
99Hypobetalipoproteinemia (HP:0003563)2.47119881
100Methylmalonic aciduria (HP:0012120)2.45743035
101Bifid uvula (HP:0000193)2.45661036
102Aplasia of the musculature (HP:0100854)2.43215319
103Capillary hemangiomas (HP:0005306)2.40463745
104Choanal stenosis (HP:0000452)2.39749270
105Aplasia/Hypoplasia of the patella (HP:0006498)2.38195621
106Type 2 muscle fiber atrophy (HP:0003554)2.36759635
107Type I transferrin isoform profile (HP:0003642)2.36094930
108Bulbar palsy (HP:0001283)2.35480569
109Hamartoma (HP:0010566)2.35206431
110Short phalanx of the thumb (HP:0009660)2.35032432
111IgA deficiency (HP:0002720)2.27730442
112Methylmalonic acidemia (HP:0002912)2.24521462
113Exercise-induced myalgia (HP:0003738)2.23392574
114Lower limb hyperreflexia (HP:0002395)2.22903181
115Clumsiness (HP:0002312)2.22858086
116Horseshoe kidney (HP:0000085)2.22681303
117Oligomenorrhea (HP:0000876)2.22251580
118Generalized amyotrophy (HP:0003700)2.22163530
119Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20208198
120Dicarboxylic aciduria (HP:0003215)2.20208198
121Pendular nystagmus (HP:0012043)2.19043170
122CNS demyelination (HP:0007305)2.18452613
123Macrocytic anemia (HP:0001972)2.14899982
124Ketoacidosis (HP:0001993)2.14169824
125Bowed forearm bones (HP:0003956)2.13581107
126Bowing of the arm (HP:0006488)2.13581107
127Opisthotonus (HP:0002179)2.13394212
128Popliteal pterygium (HP:0009756)2.12894862
129Glycosuria (HP:0003076)2.12311723
130Abnormality of urine glucose concentration (HP:0011016)2.12311723
131Hypotelorism (HP:0000601)2.10382951
132Amniotic constriction ring (HP:0009775)2.10093697
133Abnormality of placental membranes (HP:0011409)2.10093697
134Increased serum pyruvate (HP:0003542)2.08982512
135Abnormality of DNA repair (HP:0003254)2.08532599
136Ectopic kidney (HP:0000086)2.07888885
137Abnormality of the renal collecting system (HP:0004742)2.07492352
138Amelogenesis imperfecta (HP:0000705)2.05797578
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05793050
140Pancytopenia (HP:0001876)2.05526813
141Aplasia/hypoplasia of the uterus (HP:0008684)2.03989351
142Metabolic acidosis (HP:0001942)2.00323796
143Respiratory difficulties (HP:0002880)2.00177891
144Decreased subcutaneous fat (HP:0001002)2.00097524
145Hyperglycinuria (HP:0003108)1.99336263
146Hyperglycinemia (HP:0002154)1.99334460
147Paralysis (HP:0003470)1.99330137
148Gastrointestinal dysmotility (HP:0002579)1.98282794
149Abnormality of endocrine pancreas physiology (HP:0012093)1.97415535
150Abnormality of the pancreatic islet cells (HP:0006476)1.97415535
151Fused cervical vertebrae (HP:0002949)1.97232164
152Hypoplasia of the radius (HP:0002984)1.96891782
153Pallor (HP:0000980)1.96733933
154Acute hepatic failure (HP:0006554)1.95975785
155Aplastic anemia (HP:0001915)1.95690208
156Generalized aminoaciduria (HP:0002909)1.94668071
157Abnormality of glycolysis (HP:0004366)1.91435845
158X-linked dominant inheritance (HP:0001423)1.91281045
159Abnormality of renal resorption (HP:0011038)1.90758259
160Hyperammonemia (HP:0001987)1.90624705
161Hypercortisolism (HP:0001578)1.90216072
162Vertebral fusion (HP:0002948)1.89284962
163Abnormality of glycine metabolism (HP:0010895)1.89237254
164Abnormality of serine family amino acid metabolism (HP:0010894)1.89237254
165Increased number of teeth (HP:0011069)1.89227259
166Abnormal protein glycosylation (HP:0012346)1.88763209
167Abnormal glycosylation (HP:0012345)1.88763209
168Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88763209
169Abnormal protein N-linked glycosylation (HP:0012347)1.88763209
170Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88003116
171Volvulus (HP:0002580)1.87933531
172Abnormality of reticulocytes (HP:0004312)1.87829588
173Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87340406
174Emotional lability (HP:0000712)1.87079138
175Severe muscular hypotonia (HP:0006829)1.86927879
176Duplicated collecting system (HP:0000081)1.84845166
177Hypoplasia of the uterus (HP:0000013)1.83105513
178Pancreatic cysts (HP:0001737)1.81677050
179Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78719230
180True hermaphroditism (HP:0010459)1.78363452
181Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74471975
182Abnormality of alanine metabolism (HP:0010916)1.74471975
183Hyperalaninemia (HP:0003348)1.74471975
184Short thumb (HP:0009778)1.73966229
185Abnormality of the heme biosynthetic pathway (HP:0010472)1.68670541
186Pancreatic fibrosis (HP:0100732)1.67972802
187Cerebral palsy (HP:0100021)1.67804866
188Meckel diverticulum (HP:0002245)1.67728303
189Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.67295593
190Microvesicular hepatic steatosis (HP:0001414)1.66250051
191Sclerocornea (HP:0000647)1.64920713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.64412730
2ICK5.61571693
3MAPK155.07267663
4DDR24.74759080
5MAP3K64.67092712
6MAP3K114.02694947
7PINK13.65650843
8PIM22.96172108
9MATK2.91987787
10TAF12.88581132
11STK162.88419745
12DAPK12.75040712
13FGR2.59851578
14TYRO32.54329769
15MAP3K92.41382068
16VRK12.37036783
17NUAK12.24592220
18NME12.21785257
19GRK12.16208040
20UHMK12.14644246
21BMX2.10577167
22PRKD22.04381943
23CSK2.01703147
24YES12.00304307
25DYRK1B1.92128390
26EIF2AK11.88276643
27PBK1.85849867
28CDK71.80154385
29PDGFRA1.73159476
30TLK11.71081240
31ZAK1.70841563
32PDK21.63629361
33CDK91.63223349
34CSNK1G31.49502902
35AKT31.48440056
36MUSK1.47575809
37PIM11.45028858
38BMPR1B1.39995922
39TRPM71.39945471
40MAPK111.34616939
41MAP4K21.34274104
42RPS6KL11.33115159
43RPS6KC11.33115159
44LATS21.29993635
45PHKG21.29713012
46PHKG11.29713012
47WNK31.27044091
48CDK61.25789886
49BCKDK1.23038058
50RPS6KA61.19052069
51SRPK11.19025310
52MARK11.18167472
53LIMK11.15746782
54CSNK1G21.15064471
55TAOK21.13684156
56ADRBK21.10325707
57CDC42BPA1.08540579
58CDK191.07879159
59INSRR1.05328714
60SMG11.04326027
61CSNK1A1L1.03392755
62ARAF1.00877555
63PLK31.00643962
64DYRK30.99484248
65TAOK30.99068374
66GSK3A0.98469183
67NME20.97571673
68MST40.96177090
69MAPKAPK50.95217411
70PLK40.93537830
71EIF2AK30.92152479
72CHEK20.91926281
73OBSCN0.90998147
74CCNB10.90831811
75PLK10.90124319
76TRIB30.85939247
77ABL20.83648491
78MAP3K100.80817298
79BUB10.80754245
80PLK20.79154285
81NEK10.77122066
82BRSK10.74035728
83DAPK30.73069124
84MAP2K70.72963438
85TRIM280.71732217
86GRK50.70708324
87TESK10.70294344
88RAF10.69723871
89PRPF4B0.69312002
90CASK0.68600230
91EIF2AK20.67339357
92RPS6KA10.66453115
93MAP2K10.65883256
94PRKAA10.65504842
95MAPK130.64718631
96WEE10.63833811
97MAP3K120.63511904
98TSSK60.63321929
99TTK0.61015643
100RPS6KA50.56572323
101RPS6KB20.54422717
102CSNK2A10.53546736
103ATR0.52628735
104MTOR0.52194499
105CSNK1A10.51282378
106PRKCG0.51001668
107AURKA0.49641716
108HIPK20.48509611
109EPHA20.48479007
110CAMK2G0.46891100
111LYN0.43837213
112BRAF0.43727934
113TESK20.43725769
114MAPK40.43433836
115MAPKAPK30.42434564
116TAOK10.40540566
117RPS6KB10.39762910
118CDK20.38948727
119CDK80.36907868
120IKBKB0.36395571
121MAPK30.35676204
122PASK0.35113030
123CSNK2A20.34476728
124NEK20.34045818
125EGFR0.33957311
126DYRK20.33447951
127PRKACA0.33100066
128AURKB0.32449397
129FLT30.31137140
130TNIK0.30987543
131CAMK2B0.30099505
132STK40.29851318
133AKT20.29808356
134OXSR10.29173659
135ERBB30.29112519
136MAP4K10.28453813
137KDR0.27720897
138MAPK10.27440950
139CDK40.27301397
140LRRK20.27245658
141PRKAA20.27078406
142MAPKAPK20.25055228
143TNK20.25005639
144ADRBK10.24487190
145CSNK1G10.24108972
146STK38L0.22602088
147CDC70.21732090
148PRKCD0.19405465
149CAMK2D0.18843700
150CHEK10.17682037
151PAK40.16710459
152MAPK140.16592183
153PRKCZ0.15854325
154PAK10.15684394
155ATM0.15232924
156CAMK2A0.15018559
157CDK10.13794232
158PRKCI0.13370229
159PDK40.13347110
160PDK30.13347110
161ILK0.12210167
162PRKACG0.11756638
163CDK11A0.11111846
164INSR0.10174767
165MAPK100.10122581

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.70627404
2Mismatch repair_Homo sapiens_hsa034304.61115596
3Base excision repair_Homo sapiens_hsa034104.40874889
4DNA replication_Homo sapiens_hsa030303.88928117
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.96993106
6Alzheimers disease_Homo sapiens_hsa050102.36380555
7Biosynthesis of amino acids_Homo sapiens_hsa012302.34212489
8Arginine and proline metabolism_Homo sapiens_hsa003302.22694682
9Nucleotide excision repair_Homo sapiens_hsa034202.21521286
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10876235
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09523133
12Fatty acid metabolism_Homo sapiens_hsa012122.07660753
13Sulfur relay system_Homo sapiens_hsa041222.07221121
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97834435
15Protein export_Homo sapiens_hsa030601.97255526
16Folate biosynthesis_Homo sapiens_hsa007901.89252085
17Spliceosome_Homo sapiens_hsa030401.85853102
18Homologous recombination_Homo sapiens_hsa034401.74894787
19RNA transport_Homo sapiens_hsa030131.68887615
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67303250
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66169212
22Sulfur metabolism_Homo sapiens_hsa009201.62384368
23Ribosome_Homo sapiens_hsa030101.59372855
24Arginine biosynthesis_Homo sapiens_hsa002201.59358898
25Circadian rhythm_Homo sapiens_hsa047101.52706120
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44425157
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43689427
28Fructose and mannose metabolism_Homo sapiens_hsa000511.40864884
29Proteasome_Homo sapiens_hsa030501.37170449
30mRNA surveillance pathway_Homo sapiens_hsa030151.33437146
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30641493
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29009944
33Fanconi anemia pathway_Homo sapiens_hsa034601.28128573
34p53 signaling pathway_Homo sapiens_hsa041151.24686375
35mTOR signaling pathway_Homo sapiens_hsa041501.21134024
36Notch signaling pathway_Homo sapiens_hsa043301.20672426
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13705692
38Basal transcription factors_Homo sapiens_hsa030221.13266690
39Butanoate metabolism_Homo sapiens_hsa006501.12011520
40One carbon pool by folate_Homo sapiens_hsa006701.11433095
41Caffeine metabolism_Homo sapiens_hsa002321.09795130
42Collecting duct acid secretion_Homo sapiens_hsa049661.09740470
43Hippo signaling pathway_Homo sapiens_hsa043901.08254312
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.06205043
45Chemical carcinogenesis_Homo sapiens_hsa052041.05837882
46Carbon metabolism_Homo sapiens_hsa012001.05082147
47Hedgehog signaling pathway_Homo sapiens_hsa043401.03877535
48Cell cycle_Homo sapiens_hsa041101.02857085
49Purine metabolism_Homo sapiens_hsa002301.01849050
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98348353
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94896482
52Propanoate metabolism_Homo sapiens_hsa006400.94536052
53Glutathione metabolism_Homo sapiens_hsa004800.94339041
54Bladder cancer_Homo sapiens_hsa052190.93577817
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92732150
56Galactose metabolism_Homo sapiens_hsa000520.91771760
57Lysine degradation_Homo sapiens_hsa003100.90729158
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87979034
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87843178
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87795105
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86885119
62Adherens junction_Homo sapiens_hsa045200.84805840
63Pyruvate metabolism_Homo sapiens_hsa006200.84230698
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.82504529
65Fatty acid elongation_Homo sapiens_hsa000620.81218178
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77759131
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76186034
68Pyrimidine metabolism_Homo sapiens_hsa002400.76083792
69Fatty acid degradation_Homo sapiens_hsa000710.76037053
70Tyrosine metabolism_Homo sapiens_hsa003500.75673469
71Shigellosis_Homo sapiens_hsa051310.75591730
72Selenocompound metabolism_Homo sapiens_hsa004500.74796021
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.72597641
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70726420
75RNA polymerase_Homo sapiens_hsa030200.69889619
76TGF-beta signaling pathway_Homo sapiens_hsa043500.68721028
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67731831
78Primary immunodeficiency_Homo sapiens_hsa053400.67515824
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.66971299
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65422272
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.64466087
82Tryptophan metabolism_Homo sapiens_hsa003800.61084128
83Parkinsons disease_Homo sapiens_hsa050120.60955263
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60901981
85Non-homologous end-joining_Homo sapiens_hsa034500.56963672
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55852855
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.55480723
88Retinol metabolism_Homo sapiens_hsa008300.54315128
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54301542
90Pentose phosphate pathway_Homo sapiens_hsa000300.53618373
91Phenylalanine metabolism_Homo sapiens_hsa003600.52111495
92Asthma_Homo sapiens_hsa053100.51600419
93Phototransduction_Homo sapiens_hsa047440.51349602
94Nitrogen metabolism_Homo sapiens_hsa009100.49554580
95Legionellosis_Homo sapiens_hsa051340.48897151
96Oxidative phosphorylation_Homo sapiens_hsa001900.47820932
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47470757
98Huntingtons disease_Homo sapiens_hsa050160.47442129
99Starch and sucrose metabolism_Homo sapiens_hsa005000.47279049
100Peroxisome_Homo sapiens_hsa041460.46447673
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.45976410
102VEGF signaling pathway_Homo sapiens_hsa043700.45927710
103Vitamin digestion and absorption_Homo sapiens_hsa049770.45843738
104Linoleic acid metabolism_Homo sapiens_hsa005910.45302111
105beta-Alanine metabolism_Homo sapiens_hsa004100.44842848
106Wnt signaling pathway_Homo sapiens_hsa043100.44692148
107N-Glycan biosynthesis_Homo sapiens_hsa005100.42383978
108Metabolic pathways_Homo sapiens_hsa011000.41906331
109Oocyte meiosis_Homo sapiens_hsa041140.41692633
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41669685
111Basal cell carcinoma_Homo sapiens_hsa052170.41578482
112Viral myocarditis_Homo sapiens_hsa054160.37948642
113AMPK signaling pathway_Homo sapiens_hsa041520.37705462
114Fat digestion and absorption_Homo sapiens_hsa049750.36685759
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35996904
116RNA degradation_Homo sapiens_hsa030180.35972284
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35376684
118Arachidonic acid metabolism_Homo sapiens_hsa005900.34855257
119Vitamin B6 metabolism_Homo sapiens_hsa007500.34413850
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33902344
121Thyroid cancer_Homo sapiens_hsa052160.32264704
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.30094308
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29646555
124Insulin signaling pathway_Homo sapiens_hsa049100.29114933
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29049185
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28078198
127Steroid biosynthesis_Homo sapiens_hsa001000.26479051
128Colorectal cancer_Homo sapiens_hsa052100.25547616
129Acute myeloid leukemia_Homo sapiens_hsa052210.24397727
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22965988
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22843920
132PPAR signaling pathway_Homo sapiens_hsa033200.22282329
133Cardiac muscle contraction_Homo sapiens_hsa042600.21211736
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19785743

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