TXNDC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.87881619
2COPI coating of Golgi vesicle (GO:0048205)4.87881619
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.54126115
4purine nucleobase biosynthetic process (GO:0009113)4.36139440
5nucleobase biosynthetic process (GO:0046112)4.24977995
6positive regulation of hormone biosynthetic process (GO:0046886)4.24538146
7establishment of integrated proviral latency (GO:0075713)4.23160479
8positive regulation of megakaryocyte differentiation (GO:0045654)4.20075265
9negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.97614180
10formation of translation preinitiation complex (GO:0001731)3.95607461
11chromatin remodeling at centromere (GO:0031055)3.93820518
12positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.92006723
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74671964
14folic acid-containing compound biosynthetic process (GO:0009396)3.74393346
15establishment of viral latency (GO:0019043)3.69344117
16cullin deneddylation (GO:0010388)3.63592862
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57293653
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53738088
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52996927
20protein deneddylation (GO:0000338)3.52160868
21negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.50297838
22chaperone-mediated protein transport (GO:0072321)3.48995848
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.47096923
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46067584
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41360004
26negative regulation of ligase activity (GO:0051352)3.41360004
27regulation of mitochondrial translation (GO:0070129)3.36473494
28negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.32042630
29protein retention in ER lumen (GO:0006621)3.31881871
30regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.24089016
31protein localization to chromosome, centromeric region (GO:0071459)3.23750587
32DNA strand elongation involved in DNA replication (GO:0006271)3.21820195
33tRNA aminoacylation for protein translation (GO:0006418)3.20842655
34signal peptide processing (GO:0006465)3.18990895
35positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17688648
36L-serine metabolic process (GO:0006563)3.17452119
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.12917260
38regulation of histone H3-K9 methylation (GO:0051570)3.12343146
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11177450
40tRNA aminoacylation (GO:0043039)3.10271080
41amino acid activation (GO:0043038)3.10271080
42mitotic metaphase plate congression (GO:0007080)3.10172012
43negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.09955488
44protein K6-linked ubiquitination (GO:0085020)3.07678182
45histone exchange (GO:0043486)3.07625435
46regulation of cellular amino acid metabolic process (GO:0006521)3.07112021
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06789334
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06789334
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06789334
50DNA strand elongation (GO:0022616)3.06372932
51signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05706656
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05706656
53DNA catabolic process, exonucleolytic (GO:0000738)3.05623033
54dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.05484011
55regulation of translation in response to stress (GO:0043555)3.04477011
56serine family amino acid biosynthetic process (GO:0009070)3.04245406
57positive regulation of ligase activity (GO:0051351)3.02357342
58proteasome assembly (GO:0043248)3.01583834
59signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01520122
60signal transduction involved in DNA damage checkpoint (GO:0072422)3.01520122
61ribosome assembly (GO:0042255)3.01062554
62positive regulation of hormone metabolic process (GO:0032352)2.99663449
63tetrahydrofolate metabolic process (GO:0046653)2.99089033
64protein maturation by protein folding (GO:0022417)2.98528877
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98486010
66signal transduction involved in cell cycle checkpoint (GO:0072395)2.96437138
67IMP biosynthetic process (GO:0006188)2.95299919
68DNA ligation (GO:0006266)2.93801571
69telomere maintenance via semi-conservative replication (GO:0032201)2.92721587
70cellular copper ion homeostasis (GO:0006878)2.91265380
71transcription-coupled nucleotide-excision repair (GO:0006283)2.89700422
72folic acid metabolic process (GO:0046655)2.89367406
73regulation of meiosis I (GO:0060631)2.89186225
74nuclear pore organization (GO:0006999)2.88911060
75telomere maintenance via recombination (GO:0000722)2.87755036
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87728875
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87728875
78DNA replication checkpoint (GO:0000076)2.86950464
79DNA replication-independent nucleosome assembly (GO:0006336)2.86564240
80DNA replication-independent nucleosome organization (GO:0034724)2.86564240
81pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.86225842
82negative regulation of DNA-templated transcription, elongation (GO:0032785)2.85829923
83pteridine-containing compound biosynthetic process (GO:0042559)2.84371362
84DNA double-strand break processing (GO:0000729)2.82249380
85nucleotide-excision repair, DNA gap filling (GO:0006297)2.82179284
86protein-cofactor linkage (GO:0018065)2.80703252
87regulation of ubiquitin-protein transferase activity (GO:0051438)2.78364531
88antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.77405829
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77059628
90L-methionine salvage (GO:0071267)2.75380250
91L-methionine biosynthetic process (GO:0071265)2.75380250
92amino acid salvage (GO:0043102)2.75380250
93copper ion homeostasis (GO:0055070)2.75278031
94non-recombinational repair (GO:0000726)2.73949533
95double-strand break repair via nonhomologous end joining (GO:0006303)2.73949533
96DNA deamination (GO:0045006)2.73825191
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.73028885
98termination of RNA polymerase III transcription (GO:0006386)2.73028885
99mitotic nuclear envelope disassembly (GO:0007077)2.72145950
100glycine metabolic process (GO:0006544)2.71453609
101positive regulation of cell cycle arrest (GO:0071158)2.71270411
102COPII vesicle coating (GO:0048208)2.69917873
103nucleotide-sugar biosynthetic process (GO:0009226)2.69646737
104mitotic recombination (GO:0006312)2.69083572
105nucleoside salvage (GO:0043174)2.68787049
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68435329
107granulocyte differentiation (GO:0030851)2.67646428
108mitochondrial respiratory chain complex assembly (GO:0033108)2.67504658
109regulation of ligase activity (GO:0051340)2.67202295
110G1/S transition of mitotic cell cycle (GO:0000082)2.66857548
111cell cycle G1/S phase transition (GO:0044843)2.66857548
112protein localization to kinetochore (GO:0034501)2.66359730
113pseudouridine synthesis (GO:0001522)2.65525450
114pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.64893117
115ribosomal small subunit assembly (GO:0000028)2.64575760
116nucleobase-containing small molecule interconversion (GO:0015949)2.64567528
117cysteine metabolic process (GO:0006534)2.63893352
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63560042
119spliceosomal snRNP assembly (GO:0000387)2.62945562
120folic acid-containing compound metabolic process (GO:0006760)2.62919062
121synapsis (GO:0007129)2.62412526
122regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.60420023
123ribosomal large subunit biogenesis (GO:0042273)2.60326993
124deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.60027434
125negative regulation of protein ubiquitination (GO:0031397)2.59863674
126rRNA modification (GO:0000154)2.56949146
127ribosome biogenesis (GO:0042254)2.56477220
128metaphase plate congression (GO:0051310)2.54764876
129postreplication repair (GO:0006301)2.54661861
130pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.50207647
131UMP metabolic process (GO:0046049)2.50207647
132pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.50207647
133UMP biosynthetic process (GO:0006222)2.50207647
134DNA unwinding involved in DNA replication (GO:0006268)2.49407490
135DNA replication initiation (GO:0006270)2.48058826
136mitotic spindle assembly checkpoint (GO:0007094)2.46977611
137deoxyribonucleotide biosynthetic process (GO:0009263)2.46460843
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.45892526
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.45892526
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.45892526
141negative regulation of sister chromatid segregation (GO:0033046)2.45892526
142DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.45210329
143aspartate family amino acid biosynthetic process (GO:0009067)2.45118294
144CENP-A containing nucleosome assembly (GO:0034080)2.44849289
145membrane disassembly (GO:0030397)2.44082584
146nuclear envelope disassembly (GO:0051081)2.44082584
147IMP metabolic process (GO:0046040)2.42671317
148establishment of chromosome localization (GO:0051303)2.42466080
149viral mRNA export from host cell nucleus (GO:0046784)2.41780854
150negative regulation of chromosome segregation (GO:0051985)2.41567199
151regulation of spindle organization (GO:0090224)2.41494390
152telomere maintenance via telomere lengthening (GO:0010833)2.41063202
153spindle assembly checkpoint (GO:0071173)2.40318996
154regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.38429412
155GDP-mannose metabolic process (GO:0019673)2.38127381
156UDP-N-acetylglucosamine metabolic process (GO:0006047)2.36714783
157pteridine-containing compound metabolic process (GO:0042558)2.36122610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48938691
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45993033
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.41043828
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39764967
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25937810
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.99472371
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.98571123
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93924801
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92719124
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.69182805
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57182424
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52113898
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45741143
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33629408
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29318126
16E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25574656
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25439637
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.19561361
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18285214
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.17319457
21AR_21909140_ChIP-Seq_LNCAP_Human2.07537598
22XRN2_22483619_ChIP-Seq_HELA_Human2.06794628
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04159399
24DCP1A_22483619_ChIP-Seq_HELA_Human2.02103646
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96325700
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94624922
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92435654
28VDR_23849224_ChIP-Seq_CD4+_Human1.88920903
29* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86560909
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.80880722
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79753205
32GABP_19822575_ChIP-Seq_HepG2_Human1.79697481
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72423676
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71571056
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.70443404
36FOXP3_21729870_ChIP-Seq_TREG_Human1.66732182
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66225939
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65741389
39ELK1_19687146_ChIP-ChIP_HELA_Human1.65434577
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64024708
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63240185
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62504684
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61696384
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60503663
45* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60422296
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57509402
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57472083
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55883949
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49246865
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45024001
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43382425
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.43348577
53TTF2_22483619_ChIP-Seq_HELA_Human1.42804974
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41731168
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38680295
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38150976
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37784417
58TFEB_21752829_ChIP-Seq_HELA_Human1.36571529
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35932958
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.34369888
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.33795130
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31814179
63KDM5A_27292631_Chip-Seq_BREAST_Human1.31367852
64* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31213958
65CLOCK_20551151_ChIP-Seq_293T_Human1.29993523
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29469811
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29351195
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29244275
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.27911697
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26246791
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20340389
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19601846
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.19594010
74* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19277713
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19254303
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.14893404
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14711775
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14511387
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14339422
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14160263
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13885257
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12875307
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.11999099
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.10684693
85* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10411128
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08523840
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08051341
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08051341
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08051341
90* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07830863
91CIITA_25753668_ChIP-Seq_RAJI_Human1.06822570
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06711123
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06425592
94MYC_18940864_ChIP-ChIP_HL60_Human1.06017454
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05227006
96* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04680652
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03496009
98* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03491695
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01635144
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01621360
101RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99279364
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98951568
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98352080
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97645529
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97361087
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97064133
107* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95878640
108* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95103815
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94598968
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93751108
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93234226
112* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92800057
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.90690526
114ZNF263_19887448_ChIP-Seq_K562_Human0.88036703
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87121237
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.86235461
117SPI1_23547873_ChIP-Seq_NB4_Human0.84515851
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84104163
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80885370
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75408645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.40937734
2MP0008438_abnormal_cutaneous_collagen3.26695888
3MP0003693_abnormal_embryo_hatching3.25571239
4MP0004957_abnormal_blastocyst_morpholog2.78045820
5MP0006054_spinal_hemorrhage2.44951266
6MP0003705_abnormal_hypodermis_morpholog2.41340237
7MP0002254_reproductive_system_inflammat2.25792444
8MP0003077_abnormal_cell_cycle2.16336852
9MP0002139_abnormal_hepatobiliary_system2.11305690
10MP0003186_abnormal_redox_activity2.08784191
11MP0005503_abnormal_tendon_morphology2.05548333
12MP0009840_abnormal_foam_cell2.02052587
13MP0008007_abnormal_cellular_replicative1.96536180
14MP0004272_abnormal_basement_membrane1.95112174
15MP0003111_abnormal_nucleus_morphology1.91550698
16MP0008932_abnormal_embryonic_tissue1.86457739
17MP0010094_abnormal_chromosome_stability1.76515523
18MP0005365_abnormal_bile_salt1.75114040
19MP0008058_abnormal_DNA_repair1.65870043
20MP0005083_abnormal_biliary_tract1.65248316
21MP0003195_calcinosis1.64742514
22MP0003279_aneurysm1.63899302
23MP0010030_abnormal_orbit_morphology1.62886091
24MP0001730_embryonic_growth_arrest1.60643694
25MP0003123_paternal_imprinting1.54730885
26MP0006035_abnormal_mitochondrial_morpho1.53818843
27MP0005023_abnormal_wound_healing1.52111087
28MP0001853_heart_inflammation1.51294428
29MP0009697_abnormal_copulation1.49339934
30MP0001346_abnormal_lacrimal_gland1.46971159
31MP0003566_abnormal_cell_adhesion1.46528163
32MP0005085_abnormal_gallbladder_physiolo1.43922797
33MP0003315_abnormal_perineum_morphology1.42738402
34MP0005360_urolithiasis1.42113614
35MP0006082_CNS_inflammation1.41442063
36MP0005275_abnormal_skin_tensile1.37194779
37MP0010352_gastrointestinal_tract_polyps1.35704375
38MP0004264_abnormal_extraembryonic_tissu1.29112217
39MP0003567_abnormal_fetal_cardiomyocyte1.28992449
40MP0009672_abnormal_birth_weight1.28568698
41MP0009053_abnormal_anal_canal1.28163671
42MP0003786_premature_aging1.26676692
43MP0003984_embryonic_growth_retardation1.25705686
44MP0001542_abnormal_bone_strength1.25702997
45MP0001672_abnormal_embryogenesis/_devel1.25168055
46MP0005380_embryogenesis_phenotype1.25168055
47MP0002088_abnormal_embryonic_growth/wei1.23106037
48MP0010368_abnormal_lymphatic_system1.22014896
49MP0001697_abnormal_embryo_size1.21092112
50MP0002148_abnormal_hypersensitivity_rea1.20738976
51MP0000490_abnormal_crypts_of1.19559491
52MP0000372_irregular_coat_pigmentation1.15419949
53MP0002938_white_spotting1.15371361
54MP0001915_intracranial_hemorrhage1.14350343
55MP0005408_hypopigmentation1.13975042
56MP0000350_abnormal_cell_proliferation1.13021773
57MP0005332_abnormal_amino_acid1.12872310
58MP0005058_abnormal_lysosome_morphology1.11761206
59MP0004197_abnormal_fetal_growth/weight/1.09095088
60MP0005508_abnormal_skeleton_morphology1.08730475
61MP0002080_prenatal_lethality1.07882708
62MP0005084_abnormal_gallbladder_morpholo1.06615030
63MP0001764_abnormal_homeostasis1.06045252
64MP0009384_cardiac_valve_regurgitation1.05224977
65MP0005464_abnormal_platelet_physiology1.00885020
66MP0003718_maternal_effect0.98694973
67MP0003252_abnormal_bile_duct0.98163182
68MP0003942_abnormal_urinary_system0.97630549
69MP0002653_abnormal_ependyma_morphology0.96325001
70MP0001919_abnormal_reproductive_system0.96135071
71MP0000598_abnormal_liver_morphology0.95685959
72MP0005319_abnormal_enzyme/_coenzyme0.95226329
73MP0006292_abnormal_olfactory_placode0.95073120
74MP0002086_abnormal_extraembryonic_tissu0.94973169
75MP0000358_abnormal_cell_content/0.94796681
76MP0003221_abnormal_cardiomyocyte_apopto0.93633641
77MP0004084_abnormal_cardiac_muscle0.93530511
78MP0009278_abnormal_bone_marrow0.92468796
79MP0005670_abnormal_white_adipose0.90161008
80MP0010329_abnormal_lipoprotein_level0.89965431
81MP0010307_abnormal_tumor_latency0.88911333
82MP0009333_abnormal_splenocyte_physiolog0.87966706
83MP0003941_abnormal_skin_development0.87951967
84MP0005076_abnormal_cell_differentiation0.86816228
85MP0000534_abnormal_ureter_morphology0.86793741
86MP0001756_abnormal_urination0.86559962
87MP0001958_emphysema0.86309012
88MP0005165_increased_susceptibility_to0.85188971
89MP0001881_abnormal_mammary_gland0.85105243
90MP0002085_abnormal_embryonic_tissue0.84951894
91MP0003943_abnormal_hepatobiliary_system0.84864008
92MP0008057_abnormal_DNA_replication0.83878979
93MP0005623_abnormal_meninges_morphology0.83657834
94MP0001929_abnormal_gametogenesis0.83475303
95MP0000613_abnormal_salivary_gland0.83262788
96MP0002210_abnormal_sex_determination0.83211093
97MP0003183_abnormal_peptide_metabolism0.82905206
98MP0003119_abnormal_digestive_system0.82586686
99MP0002160_abnormal_reproductive_system0.82320979
100MP0002090_abnormal_vision0.81997113
101MP0001293_anophthalmia0.81621879
102MP0002277_abnormal_respiratory_mucosa0.81399989
103MP0005075_abnormal_melanosome_morpholog0.81123685
104MP0005220_abnormal_exocrine_pancreas0.80970127
105MP0003191_abnormal_cellular_cholesterol0.80152225
106MP0001145_abnormal_male_reproductive0.79275327
107MP0003936_abnormal_reproductive_system0.79210205
108MP0002084_abnormal_developmental_patter0.79190982
109MP0001666_abnormal_nutrient_absorption0.79082012
110MP0008260_abnormal_autophagy0.78779188
111MP0005389_reproductive_system_phenotype0.77943477
112MP0009643_abnormal_urine_homeostasis0.77093925
113MP0009785_altered_susceptibility_to0.76426866
114MP0002877_abnormal_melanocyte_morpholog0.76280442
115MP0005367_renal/urinary_system_phenotyp0.76248496
116MP0000516_abnormal_urinary_system0.76248496
117MP0000609_abnormal_liver_physiology0.76165021
118MP0005410_abnormal_fertilization0.76065668
119MP0004147_increased_porphyrin_level0.76027340
120MP0002138_abnormal_hepatobiliary_system0.73838416
121MP0000313_abnormal_cell_death0.73771080
122MP0000653_abnormal_sex_gland0.73162341
123MP0000858_altered_metastatic_potential0.73022331
124MP0002282_abnormal_trachea_morphology0.71007209
125MP0002111_abnormal_tail_morphology0.70918572
126MP0009703_decreased_birth_body0.70736238
127MP0008875_abnormal_xenobiotic_pharmacok0.70672741
128MP0005390_skeleton_phenotype0.70550018
129MP0002132_abnormal_respiratory_system0.70056792
130MP0004019_abnormal_vitamin_homeostasis0.69973263
131MP0002019_abnormal_tumor_incidence0.69269413
132MP0001984_abnormal_olfaction0.69196644
133MP0005310_abnormal_salivary_gland0.69022942
134MP0003937_abnormal_limbs/digits/tail_de0.68761262
135MP0006036_abnormal_mitochondrial_physio0.67924731
136MP0003890_abnormal_embryonic-extraembry0.67808437
137MP0001119_abnormal_female_reproductive0.66653372
138MP0008873_increased_physiological_sensi0.66008356
139MP0009763_increased_sensitivity_to0.65746809
140MP0005174_abnormal_tail_pigmentation0.64836388
141MP0000627_abnormal_mammary_gland0.63390446
142MP0001324_abnormal_eye_pigmentation0.63387794
143MP0002006_tumorigenesis0.62744544
144MP0009764_decreased_sensitivity_to0.61746678
145MP0005671_abnormal_response_to0.61391871

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)3.68711029
2Protrusio acetabuli (HP:0003179)3.50269133
3Abnormality of the anterior horn cell (HP:0006802)3.47163153
4Degeneration of anterior horn cells (HP:0002398)3.47163153
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40999002
6Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40999002
7Premature rupture of membranes (HP:0001788)3.38287371
8Acute necrotizing encephalopathy (HP:0006965)3.18832027
9Acute encephalopathy (HP:0006846)3.18016523
10Hepatocellular necrosis (HP:0001404)3.08742006
11Vertebral compression fractures (HP:0002953)3.07366537
12Abnormal protein glycosylation (HP:0012346)3.04827163
13Abnormal glycosylation (HP:0012345)3.04827163
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.04827163
15Abnormal protein N-linked glycosylation (HP:0012347)3.04827163
16Abnormal mitochondria in muscle tissue (HP:0008316)3.03529735
17Increased serum pyruvate (HP:0003542)3.00523921
18Abnormality of glycolysis (HP:0004366)3.00523921
19Carpal bone hypoplasia (HP:0001498)2.96843291
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96013678
21Stenosis of the external auditory canal (HP:0000402)2.95906932
22Increased CSF lactate (HP:0002490)2.91516655
23Biconcave vertebral bodies (HP:0004586)2.90590593
24Rough bone trabeculation (HP:0100670)2.88752008
25Reduced antithrombin III activity (HP:0001976)2.82073751
26Hypobetalipoproteinemia (HP:0003563)2.81706656
27Mitochondrial inheritance (HP:0001427)2.78226071
28Cervical subluxation (HP:0003308)2.78196394
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.72102109
30Reticulocytopenia (HP:0001896)2.70780483
31Poor head control (HP:0002421)2.69028151
32Abnormality of aromatic amino acid family metabolism (HP:0004338)2.68224084
33Cerebral edema (HP:0002181)2.67558809
34Meckel diverticulum (HP:0002245)2.66893007
35Lactic acidosis (HP:0003128)2.62641593
36Increased hepatocellular lipid droplets (HP:0006565)2.62026186
37Metaphyseal cupping (HP:0003021)2.60989513
38Increased serum lactate (HP:0002151)2.59936786
39Gonadotropin excess (HP:0000837)2.59805516
40Cerebral hypomyelination (HP:0006808)2.59715062
41Aplastic anemia (HP:0001915)2.59582552
42Chromsome breakage (HP:0040012)2.56813087
43Abnormality of fatty-acid metabolism (HP:0004359)2.55480788
44Abnormality of the ileum (HP:0001549)2.55305513
45Abnormality of the intrinsic pathway (HP:0010989)2.51654884
46Pancytopenia (HP:0001876)2.51570002
47Multiple enchondromatosis (HP:0005701)2.50128563
48Hyperglycinuria (HP:0003108)2.49998587
49Abnormality of the umbilical cord (HP:0010881)2.47992680
50Intrahepatic cholestasis (HP:0001406)2.46541435
51Lipid accumulation in hepatocytes (HP:0006561)2.46078162
52Hypoglycemic seizures (HP:0002173)2.44287060
53Breast hypoplasia (HP:0003187)2.44170288
54Beaking of vertebral bodies (HP:0004568)2.43456285
55Birth length less than 3rd percentile (HP:0003561)2.34697583
56Generalized aminoaciduria (HP:0002909)2.33919471
57CNS demyelination (HP:0007305)2.32925347
58Loss of speech (HP:0002371)2.31918513
59Colon cancer (HP:0003003)2.31752490
60Abnormal lung lobation (HP:0002101)2.28978688
61Premature ovarian failure (HP:0008209)2.28840785
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.26634585
63Poikiloderma (HP:0001029)2.26288617
64Progressive macrocephaly (HP:0004481)2.26272127
65Hyperglycemia (HP:0003074)2.23882648
66Nonimmune hydrops fetalis (HP:0001790)2.21912622
67Abnormal number of erythroid precursors (HP:0012131)2.21339346
68Neoplasm of the adrenal gland (HP:0100631)2.18319433
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.17111155
70Abnormality of the preputium (HP:0100587)2.14910424
71Horseshoe kidney (HP:0000085)2.14027384
72Abnormal trabecular bone morphology (HP:0100671)2.13139155
73Abnormal cartilage morphology (HP:0002763)2.12714541
74Abnormality of cells of the erythroid lineage (HP:0012130)2.10321323
75Nausea (HP:0002018)2.09201446
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07869522
77Abnormality of alanine metabolism (HP:0010916)2.07869522
78Hyperalaninemia (HP:0003348)2.07869522
79Abnormal umbilical cord blood vessels (HP:0011403)2.07463502
80Single umbilical artery (HP:0001195)2.07463502
81Abnormality of the fetal cardiovascular system (HP:0010948)2.07463502
82Oral leukoplakia (HP:0002745)2.06611022
83Macrocytic anemia (HP:0001972)2.06211994
84Soft skin (HP:0000977)2.06184742
85Hepatosplenomegaly (HP:0001433)2.05489597
86Gout (HP:0001997)2.05283604
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04951756
88Dicarboxylic aciduria (HP:0003215)2.04951756
89Abnormality of glycolipid metabolism (HP:0010969)2.03559312
90Abnormality of liposaccharide metabolism (HP:0010968)2.03559312
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.03559312
92Duodenal stenosis (HP:0100867)2.03479595
93Small intestinal stenosis (HP:0012848)2.03479595
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02571030
95Death in infancy (HP:0001522)2.01849485
96Hypolipoproteinemia (HP:0010981)2.01684308
97Cleft eyelid (HP:0000625)2.01643826
98Cortical dysplasia (HP:0002539)2.01154811
99Microvesicular hepatic steatosis (HP:0001414)2.01137576
100Selective tooth agenesis (HP:0001592)2.00645725
101Deep venous thrombosis (HP:0002625)2.00102901
102Abnormality of chromosome stability (HP:0003220)1.99465770
103Hyperinsulinemic hypoglycemia (HP:0000825)1.99464203
104Pancreatic islet-cell hyperplasia (HP:0004510)1.98802544
1053-Methylglutaconic aciduria (HP:0003535)1.98481474
106Hyperammonemia (HP:0001987)1.98480149
107Bilateral microphthalmos (HP:0007633)1.97820727
108Proximal tubulopathy (HP:0000114)1.97149438
109Absent thumb (HP:0009777)1.97042082
110Abolished electroretinogram (ERG) (HP:0000550)1.96064450
111Abnormality of dentin (HP:0010299)1.94923365
112Type I transferrin isoform profile (HP:0003642)1.93707485
113Patent foramen ovale (HP:0001655)1.92808420
114Agnosia (HP:0010524)1.91156969
115Megaloblastic anemia (HP:0001889)1.91098170
116Abnormality of the common coagulation pathway (HP:0010990)1.89366254
117Sparse eyelashes (HP:0000653)1.89100797
118Abnormality of pyrimidine metabolism (HP:0004353)1.88251662
119Hyperglycinemia (HP:0002154)1.86867300
120Lethargy (HP:0001254)1.86657226
121Abnormality of methionine metabolism (HP:0010901)1.85336156
122Abnormality of serum amino acid levels (HP:0003112)1.85168909
123Irregular epiphyses (HP:0010582)1.84663854
124Postnatal microcephaly (HP:0005484)1.83668649
125Abnormal spermatogenesis (HP:0008669)1.83408755
126Blue sclerae (HP:0000592)1.83289758
127Respiratory failure (HP:0002878)1.83054315
128Ragged-red muscle fibers (HP:0003200)1.83035622
129Abnormality of endocrine pancreas physiology (HP:0012093)1.81136897
130Abnormality of the pancreatic islet cells (HP:0006476)1.81136897
131Hypoplasia of the uterus (HP:0000013)1.80676545
132Spastic paraparesis (HP:0002313)1.80165647
133Platyspondyly (HP:0000926)1.79205555
134Abnormality of the duodenum (HP:0002246)1.79078599
135Increased intramyocellular lipid droplets (HP:0012240)1.78564075
136Facial diplegia (HP:0001349)1.78480006
137Epiphyseal stippling (HP:0010655)1.76720569
138Rectovaginal fistula (HP:0000143)1.76261167
139Rectal fistula (HP:0100590)1.76261167
140Missing ribs (HP:0000921)1.75620382
141Palpitations (HP:0001962)1.74968567
142Opisthotonus (HP:0002179)1.74247257
143Fat malabsorption (HP:0002630)1.73871576
144Hepatic necrosis (HP:0002605)1.73368834
145Vaginal fistula (HP:0004320)1.73034180
146Xanthomatosis (HP:0000991)1.72544823
147Trismus (HP:0000211)1.72202906
148Secondary amenorrhea (HP:0000869)1.71560192
149Ovarian neoplasm (HP:0100615)1.70479508
150Slender long bone (HP:0003100)1.69913201
151Patellar aplasia (HP:0006443)1.69810007
152Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68470783
153Aplasia/Hypoplasia of the patella (HP:0006498)1.68313565
154Abnormality of glycine metabolism (HP:0010895)1.67308741
155Abnormality of serine family amino acid metabolism (HP:0010894)1.67308741
156Delayed CNS myelination (HP:0002188)1.67201824
157Abnormality of the acetabulum (HP:0003170)1.66944449
158Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66658086
159Abnormal epiphyseal ossification (HP:0010656)1.65155701
160Abnormality of sulfur amino acid metabolism (HP:0004339)1.64966208
161Ankle contracture (HP:0006466)1.63261678
162Premature graying of hair (HP:0002216)1.63184046
163Prominent metopic ridge (HP:0005487)1.62578549
164Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62374195
165Hepatocellular carcinoma (HP:0001402)1.62280786
166Prolonged neonatal jaundice (HP:0006579)1.62059501
167Cardiovascular calcification (HP:0011915)1.61800685
16811 pairs of ribs (HP:0000878)1.60653730
169Ureteral duplication (HP:0000073)1.60643469
170Tongue fasciculations (HP:0001308)1.59701940
171Abnormal pancreas size (HP:0012094)1.59308235
172Microretrognathia (HP:0000308)1.59130478
173Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.58496588
174Vacuolated lymphocytes (HP:0001922)1.58162121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.82391149
2BUB13.95637377
3WEE12.89062551
4MST42.87451022
5TESK22.73506856
6TESK12.67100688
7NEK12.59412858
8EIF2AK12.59394927
9BCKDK2.49592802
10TSSK62.23813973
11PLK42.11221975
12PDK22.07465151
13PNCK2.06208389
14ERN11.98979356
15TRIB31.98633214
16CDK191.93344353
17BRSK21.90509156
18PASK1.87301311
19ACVR1B1.86741669
20NME21.84959806
21EPHA21.80862312
22SRPK11.78603393
23TRIM281.78263659
24PIM21.76616502
25CCNB11.73845730
26EIF2AK31.70250205
27NEK21.69369956
28PKN21.69063409
29PAK41.67384090
30LIMK11.63429228
31MAP3K121.53238313
32NEK91.49681453
33PBK1.46945725
34PDK41.46233926
35PDK31.46233926
36STK38L1.45668063
37CDC71.44494255
38TTK1.42423456
39STK161.40242022
40TXK1.39619926
41PLK31.37241462
42RPS6KA41.37182569
43AKT31.33628064
44PLK11.30719986
45MAP4K21.24020378
46KDR1.21527415
47TGFBR11.19429719
48CDK81.15102080
49BRSK11.13636343
50ZAK1.12581670
51ILK1.09809774
52NUAK11.05703875
53BRAF1.03920227
54FLT31.03280980
55AURKB0.97459724
56STK240.96249174
57MKNK10.89711491
58ATR0.84291380
59ERBB30.83468643
60LRRK20.82662745
61MAP3K80.81927875
62TAF10.81234872
63NME10.80294777
64VRK10.78539542
65TIE10.78516871
66STK30.77363803
67ARAF0.76882830
68CDK40.76149135
69CDK70.75696825
70PAK10.75284466
71TLK10.74767909
72BCR0.74261566
73CAMK1G0.72645876
74AURKA0.71884921
75DYRK30.71048874
76PIM10.69712076
77WNK40.67876951
78BMPR1B0.67109354
79ZAP700.65913095
80FGFR40.64492047
81CLK10.63971824
82SIK10.63640875
83PTK60.59735738
84MET0.59583716
85RPS6KB20.59571349
86CSNK1G30.58894935
87CSNK2A10.58858752
88ATM0.57250290
89PDGFRA0.54607907
90STK40.53758560
91PRKCI0.53465301
92CSNK1G10.52720142
93IRAK40.52538339
94TBK10.51880186
95WNK30.51093227
96MYLK0.48685247
97GRK10.47514264
98MAP3K110.45787144
99CSNK1A1L0.45435463
100ABL20.45261731
101DYRK20.44941844
102FGFR10.44558301
103CHEK20.43864651
104CHEK10.43633041
105CHUK0.43158273
106MATK0.42293341
107ALK0.42243939
108DAPK10.42241838
109MELK0.41548621
110PLK20.41217639
111YES10.40885851
112MAP3K50.39842439
113IRAK30.39799118
114CSNK2A20.39551768
115CDK90.39383207
116STK100.38789700
117TEC0.38552551
118GRK70.37966565
119OXSR10.37220606
120INSRR0.36874008
121LATS20.36072568
122MAP3K30.35677925
123CSNK1G20.35556601
124CDK60.35220845
125ERBB40.35182027
126IRAK10.34842180
127MAPKAPK50.34014455
128DDR20.33381602
129DAPK30.32839608
130MTOR0.32346969
131IGF1R0.31249909
132SCYL20.30240632
133ADRBK20.30116050
134CDK20.29121340
135EIF2AK20.29107602
136PAK20.27853079
137CSNK1E0.27843989
138PRKG20.27043528
139RAF10.26802440
140MOS0.25168933
141CDK140.20068060

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.78753818
2DNA replication_Homo sapiens_hsa030302.84884251
3Mismatch repair_Homo sapiens_hsa034302.58400114
4One carbon pool by folate_Homo sapiens_hsa006702.51637962
5Protein export_Homo sapiens_hsa030602.14258873
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12961255
7RNA polymerase_Homo sapiens_hsa030202.07943425
8Base excision repair_Homo sapiens_hsa034101.99091677
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95996270
10RNA transport_Homo sapiens_hsa030131.92836068
11Oxidative phosphorylation_Homo sapiens_hsa001901.90085235
12Spliceosome_Homo sapiens_hsa030401.85181207
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84216799
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83776943
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.78772606
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77148301
17Folate biosynthesis_Homo sapiens_hsa007901.76896883
18Selenocompound metabolism_Homo sapiens_hsa004501.76418054
19Pyrimidine metabolism_Homo sapiens_hsa002401.75059302
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70986689
21Nucleotide excision repair_Homo sapiens_hsa034201.68492620
22Cell cycle_Homo sapiens_hsa041101.58938329
23Parkinsons disease_Homo sapiens_hsa050121.57952170
24Pentose phosphate pathway_Homo sapiens_hsa000301.56900803
25Biosynthesis of amino acids_Homo sapiens_hsa012301.54799151
26Carbon metabolism_Homo sapiens_hsa012001.54727432
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49019337
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.45700286
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37657565
30Ribosome_Homo sapiens_hsa030101.36186989
31Fatty acid degradation_Homo sapiens_hsa000711.33945888
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.33318454
33Homologous recombination_Homo sapiens_hsa034401.30626643
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30108098
35Huntingtons disease_Homo sapiens_hsa050161.28180565
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19745934
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.19730701
38Fructose and mannose metabolism_Homo sapiens_hsa000511.17941882
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.17701883
40Sulfur metabolism_Homo sapiens_hsa009201.15514151
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12688553
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10301560
43Galactose metabolism_Homo sapiens_hsa000521.04979317
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03229311
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03032829
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02716358
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02228470
48Fatty acid metabolism_Homo sapiens_hsa012121.00866439
49Peroxisome_Homo sapiens_hsa041461.00324782
50Tryptophan metabolism_Homo sapiens_hsa003801.00209258
51Pyruvate metabolism_Homo sapiens_hsa006200.99110351
52* Glutathione metabolism_Homo sapiens_hsa004800.97002433
53Propanoate metabolism_Homo sapiens_hsa006400.92010661
54Legionellosis_Homo sapiens_hsa051340.91519083
55Basal transcription factors_Homo sapiens_hsa030220.91476742
56N-Glycan biosynthesis_Homo sapiens_hsa005100.89450198
57p53 signaling pathway_Homo sapiens_hsa041150.89111796
58RNA degradation_Homo sapiens_hsa030180.87001166
59Fatty acid elongation_Homo sapiens_hsa000620.86402325
60Vitamin B6 metabolism_Homo sapiens_hsa007500.86079126
61Sulfur relay system_Homo sapiens_hsa041220.82633602
62Alzheimers disease_Homo sapiens_hsa050100.81941461
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78641653
64Purine metabolism_Homo sapiens_hsa002300.77424208
65Arginine and proline metabolism_Homo sapiens_hsa003300.76823998
66Epstein-Barr virus infection_Homo sapiens_hsa051690.75899824
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.75537703
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75251350
69Complement and coagulation cascades_Homo sapiens_hsa046100.74300690
70Non-homologous end-joining_Homo sapiens_hsa034500.73561164
71Lysosome_Homo sapiens_hsa041420.73521716
72Fanconi anemia pathway_Homo sapiens_hsa034600.71677551
73Other glycan degradation_Homo sapiens_hsa005110.69827936
74Nitrogen metabolism_Homo sapiens_hsa009100.69176571
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67136792
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66307640
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65898094
78Arginine biosynthesis_Homo sapiens_hsa002200.64319331
79Antigen processing and presentation_Homo sapiens_hsa046120.64188931
80Phenylalanine metabolism_Homo sapiens_hsa003600.62027013
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61528014
82Vitamin digestion and absorption_Homo sapiens_hsa049770.59443641
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.59404998
84Steroid biosynthesis_Homo sapiens_hsa001000.58254105
85Regulation of autophagy_Homo sapiens_hsa041400.57422873
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56494570
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55063208
88Chemical carcinogenesis_Homo sapiens_hsa052040.53829059
89Metabolic pathways_Homo sapiens_hsa011000.53567050
90Starch and sucrose metabolism_Homo sapiens_hsa005000.52692329
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51876930
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51496147
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51121989
94Histidine metabolism_Homo sapiens_hsa003400.49092825
95mRNA surveillance pathway_Homo sapiens_hsa030150.47919045
96Tyrosine metabolism_Homo sapiens_hsa003500.47511704
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47303391
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46612793
99Shigellosis_Homo sapiens_hsa051310.45624149
100beta-Alanine metabolism_Homo sapiens_hsa004100.44062637
101Small cell lung cancer_Homo sapiens_hsa052220.43646424
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43342154
103Fat digestion and absorption_Homo sapiens_hsa049750.42983194
104PPAR signaling pathway_Homo sapiens_hsa033200.42877803
105Staphylococcus aureus infection_Homo sapiens_hsa051500.42068428
106Rheumatoid arthritis_Homo sapiens_hsa053230.41975226
107Caffeine metabolism_Homo sapiens_hsa002320.40978428
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40819555
109Butanoate metabolism_Homo sapiens_hsa006500.40353078
110Viral carcinogenesis_Homo sapiens_hsa052030.38954783
111Arachidonic acid metabolism_Homo sapiens_hsa005900.38942986
112Primary immunodeficiency_Homo sapiens_hsa053400.37829270
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34708299
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33696474
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31618746
116Vibrio cholerae infection_Homo sapiens_hsa051100.27823734
117Collecting duct acid secretion_Homo sapiens_hsa049660.26021545
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25564126
119Oocyte meiosis_Homo sapiens_hsa041140.24455025
120Asthma_Homo sapiens_hsa053100.23350867

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