TXNDC15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.69113670
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.69113670
3L-phenylalanine metabolic process (GO:0006558)6.51108794
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.51108794
5aromatic amino acid family catabolic process (GO:0009074)5.64389843
6glyoxylate metabolic process (GO:0046487)4.94785393
7bile acid biosynthetic process (GO:0006699)4.93391771
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.90874788
9tryptophan catabolic process (GO:0006569)4.75875176
10indole-containing compound catabolic process (GO:0042436)4.75875176
11indolalkylamine catabolic process (GO:0046218)4.75875176
12sulfur amino acid catabolic process (GO:0000098)4.74963368
13alpha-linolenic acid metabolic process (GO:0036109)4.73500631
14kynurenine metabolic process (GO:0070189)4.72585207
15tryptophan metabolic process (GO:0006568)4.50278524
16cysteine metabolic process (GO:0006534)4.45880740
17negative regulation of fibrinolysis (GO:0051918)4.45338344
18peptidyl-glutamic acid carboxylation (GO:0017187)4.42045286
19protein carboxylation (GO:0018214)4.42045286
20cellular ketone body metabolic process (GO:0046950)4.40490421
21regulation of protein activation cascade (GO:2000257)4.31608416
22high-density lipoprotein particle remodeling (GO:0034375)4.31306751
23complement activation, alternative pathway (GO:0006957)4.25897400
24regulation of fibrinolysis (GO:0051917)4.24014687
25coenzyme catabolic process (GO:0009109)4.18025449
26lysine catabolic process (GO:0006554)4.15942759
27lysine metabolic process (GO:0006553)4.15942759
28urea cycle (GO:0000050)4.15492142
29urea metabolic process (GO:0019627)4.15492142
30aromatic amino acid family metabolic process (GO:0009072)4.14891282
31regulation of complement activation (GO:0030449)4.09468212
32bile acid metabolic process (GO:0008206)4.07951175
33serine family amino acid catabolic process (GO:0009071)3.93537575
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.92966912
35nitrogen cycle metabolic process (GO:0071941)3.90604020
36reverse cholesterol transport (GO:0043691)3.87999843
37alpha-amino acid catabolic process (GO:1901606)3.86911640
38tyrosine metabolic process (GO:0006570)3.86323439
39cellular modified amino acid catabolic process (GO:0042219)3.81667408
40homocysteine metabolic process (GO:0050667)3.79885228
41ketone body metabolic process (GO:1902224)3.79180400
42regulation of cholesterol esterification (GO:0010872)3.76353502
43acylglycerol homeostasis (GO:0055090)3.75903189
44triglyceride homeostasis (GO:0070328)3.75903189
45cellular amino acid catabolic process (GO:0009063)3.72163409
46plasma lipoprotein particle remodeling (GO:0034369)3.71082719
47protein-lipid complex remodeling (GO:0034368)3.71082719
48macromolecular complex remodeling (GO:0034367)3.71082719
49glutamate metabolic process (GO:0006536)3.67676517
50regulation of triglyceride catabolic process (GO:0010896)3.66133434
51short-chain fatty acid metabolic process (GO:0046459)3.64227916
52aldehyde catabolic process (GO:0046185)3.58564521
53indolalkylamine metabolic process (GO:0006586)3.57076988
54amino-acid betaine metabolic process (GO:0006577)3.56972420
55imidazole-containing compound metabolic process (GO:0052803)3.47090185
56plasma lipoprotein particle clearance (GO:0034381)3.45258957
57cofactor catabolic process (GO:0051187)3.44510607
58ethanol oxidation (GO:0006069)3.43416271
59acetyl-CoA metabolic process (GO:0006084)3.37548135
60arginine metabolic process (GO:0006525)3.37547241
61negative regulation of sterol transport (GO:0032372)3.36499762
62negative regulation of cholesterol transport (GO:0032375)3.36499762
632-oxoglutarate metabolic process (GO:0006103)3.36428571
64organic acid catabolic process (GO:0016054)3.35288931
65carboxylic acid catabolic process (GO:0046395)3.35288931
66amine catabolic process (GO:0009310)3.32164677
67cellular biogenic amine catabolic process (GO:0042402)3.32164677
68negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30324626
69cholesterol efflux (GO:0033344)3.30248398
70bile acid and bile salt transport (GO:0015721)3.29286174
71benzene-containing compound metabolic process (GO:0042537)3.29055835
72phospholipid efflux (GO:0033700)3.28095350
73monocarboxylic acid catabolic process (GO:0072329)3.27768819
74fatty acid beta-oxidation (GO:0006635)3.27335490
75epoxygenase P450 pathway (GO:0019373)3.25800443
76sequestering of extracellular ligand from receptor (GO:0035581)3.24734714
77aspartate family amino acid catabolic process (GO:0009068)3.24138349
78fatty acid oxidation (GO:0019395)3.22364248
79fatty acid catabolic process (GO:0009062)3.20797556
80cellular glucuronidation (GO:0052695)3.19281717
81serine family amino acid metabolic process (GO:0009069)3.19251063
82low-density lipoprotein particle remodeling (GO:0034374)3.19190403
83lipid oxidation (GO:0034440)3.17409619
84neuronal action potential propagation (GO:0019227)3.11911506
85cytolysis (GO:0019835)3.10738139
86regulation of plasminogen activation (GO:0010755)3.09553757
87fibrinolysis (GO:0042730)3.08974734
88drug catabolic process (GO:0042737)3.07857970
89presynaptic membrane assembly (GO:0097105)3.07003664
90complement activation, classical pathway (GO:0006958)3.05469882
91glycine metabolic process (GO:0006544)3.04562536
92very long-chain fatty acid metabolic process (GO:0000038)3.02541505
93complement activation (GO:0006956)3.02518566
94uronic acid metabolic process (GO:0006063)3.00696255
95glucuronate metabolic process (GO:0019585)3.00696255
96drug transmembrane transport (GO:0006855)3.00237477
97negative regulation of lipase activity (GO:0060192)2.97761296
98opsonization (GO:0008228)2.96729054
99serine family amino acid biosynthetic process (GO:0009070)2.96330588
100regulation of cholesterol homeostasis (GO:2000188)2.95877358
101regulation of axon extension involved in axon guidance (GO:0048841)2.95317444
102pyrimidine nucleobase catabolic process (GO:0006208)2.94415015
103valine metabolic process (GO:0006573)2.92785669
104negative regulation of protein localization to cell surface (GO:2000009)2.91881271
105plasma lipoprotein particle assembly (GO:0034377)2.91246649
106dicarboxylic acid biosynthetic process (GO:0043650)2.90781477
107presynaptic membrane organization (GO:0097090)2.88934178
108postsynaptic membrane organization (GO:0001941)2.88705337
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88062739
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.82815733
111positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.82347297
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81762505
113axonal fasciculation (GO:0007413)2.81028819
114regulation of axon guidance (GO:1902667)2.75803418
115negative regulation of axon extension involved in axon guidance (GO:0048843)2.72325628
116protein heterotrimerization (GO:0070208)2.71274698
117peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.70567141
118response to gravity (GO:0009629)2.69036259
119auditory behavior (GO:0031223)2.66105094
120neuron cell-cell adhesion (GO:0007158)2.65925722
121response to pheromone (GO:0019236)2.64554721
122C4-dicarboxylate transport (GO:0015740)2.63389894
123pericardium development (GO:0060039)2.57984896
124collagen fibril organization (GO:0030199)2.57079911
125gamma-aminobutyric acid transport (GO:0015812)2.56564252
126neuron recognition (GO:0008038)2.49690117
127smooth muscle tissue development (GO:0048745)2.49477377
128lymphangiogenesis (GO:0001946)2.49167918
129vocalization behavior (GO:0071625)2.48223331
130vascular smooth muscle contraction (GO:0014829)2.47388367
131negative regulation of axon guidance (GO:1902668)2.46347919
132nonmotile primary cilium assembly (GO:0035058)2.46069145
133positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39066944
134signal peptide processing (GO:0006465)2.38532528
135regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.38138060
136calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.36603784
137synaptic vesicle docking involved in exocytosis (GO:0016081)2.35657894
138detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.35269701
139regulation of short-term neuronal synaptic plasticity (GO:0048172)2.33703661
140macroautophagy (GO:0016236)2.33663269
141regulation of cell communication by electrical coupling (GO:0010649)2.33193988
142glycosphingolipid biosynthetic process (GO:0006688)2.32808671
143startle response (GO:0001964)2.30242739
144regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28283223
145negative regulation of complement activation (GO:0045916)2.27602963
146dermatan sulfate biosynthetic process (GO:0030208)2.26249871
147regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.25419935
148cyclic nucleotide catabolic process (GO:0009214)2.24769038
149negative regulation of nitric-oxide synthase activity (GO:0051001)2.24210753
150nucleobase catabolic process (GO:0046113)2.23330168
151regulation of action potential (GO:0098900)2.21704099
152tonic smooth muscle contraction (GO:0014820)2.21403434
153synaptic transmission, glutamatergic (GO:0035249)2.20931068
154cAMP catabolic process (GO:0006198)2.20926835
155detection of mechanical stimulus involved in sensory perception (GO:0050974)2.19518077
156regulation of cilium movement (GO:0003352)2.19001018
157membrane depolarization during action potential (GO:0086010)2.18050921
158UDP-N-acetylglucosamine metabolic process (GO:0006047)2.15724970
159positive regulation of synapse assembly (GO:0051965)2.14565758
160regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.14128744
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.14107691
162glutamate secretion (GO:0014047)2.13813634
163establishment of protein localization to Golgi (GO:0072600)2.12760983
164righting reflex (GO:0060013)2.12066418
165inner ear receptor stereocilium organization (GO:0060122)2.11113110
166mesenchymal-epithelial cell signaling (GO:0060638)2.10745902
167appendage development (GO:0048736)2.10261244
168limb development (GO:0060173)2.10261244
169dendritic spine morphogenesis (GO:0060997)2.09455483
170thyroid hormone metabolic process (GO:0042403)2.09083736
171regulation of protein glycosylation (GO:0060049)2.08794980
172positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.07734107
173positive regulation of axon extension (GO:0045773)2.07362305
174chondrocyte proliferation (GO:0035988)2.05882553
175negative chemotaxis (GO:0050919)2.05799968
176protein localization to synapse (GO:0035418)2.05347082
177synapse assembly (GO:0007416)2.05181840
178positive regulation of meiosis (GO:0045836)2.04967711
179cilium morphogenesis (GO:0060271)2.04812351
180regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.04489134
181parturition (GO:0007567)2.03945714
182neurotransmitter-gated ion channel clustering (GO:0072578)2.03934102
183membrane assembly (GO:0071709)2.03564855
184retinal cone cell development (GO:0046549)2.03373504
185regulation of synapse assembly (GO:0051963)2.02836302
186regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.01940506
187detection of calcium ion (GO:0005513)1.99481342
188regulation of integrin-mediated signaling pathway (GO:2001044)1.98638467
189homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)1.98346454
190axon extension (GO:0048675)1.98282509
191neuron-neuron synaptic transmission (GO:0007270)1.98211534
192negative regulation of protein activation cascade (GO:2000258)1.97892226
193smooth muscle contraction (GO:0006939)1.97225233
194reflex (GO:0060004)1.96897169
195central nervous system neuron axonogenesis (GO:0021955)1.96674993
196retinal ganglion cell axon guidance (GO:0031290)1.96655894
197regulation of respiratory system process (GO:0044065)1.95933775
198transmission of nerve impulse (GO:0019226)1.95837981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.02591612
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.46320378
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.38371419
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.17709059
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.79061389
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.49544072
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.95132974
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.86652891
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.98122659
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79872856
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.75095358
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55705567
13EZH2_22144423_ChIP-Seq_EOC_Human2.41080426
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20957778
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17989810
16CLOCK_20551151_ChIP-Seq_293T_Human2.15509086
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.10790746
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95581904
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93568754
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.91938638
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91030407
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90577207
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87246167
24SMAD4_21799915_ChIP-Seq_A2780_Human1.83835765
25P300_19829295_ChIP-Seq_ESCs_Human1.80209117
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76478684
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76388860
28IGF1R_20145208_ChIP-Seq_DFB_Human1.75117326
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74741481
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.69838104
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65742345
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64366551
33VDR_22108803_ChIP-Seq_LS180_Human1.61694395
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60859298
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56761117
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.54797581
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.54020474
38CJUN_26792858_Chip-Seq_BT549_Human1.53952985
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52760219
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.51911990
41HTT_18923047_ChIP-ChIP_STHdh_Human1.50646341
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50434095
43STAT3_23295773_ChIP-Seq_U87_Human1.50281737
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47134987
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45981225
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45203229
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45196653
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44674717
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43473950
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.42730209
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42144802
52FUS_26573619_Chip-Seq_HEK293_Human1.41947449
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40706508
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38179960
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.35185975
56ER_23166858_ChIP-Seq_MCF-7_Human1.33977284
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.33435338
58TP53_18474530_ChIP-ChIP_U2OS_Human1.33350312
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32369603
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31975495
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31431306
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31112134
63TP53_16413492_ChIP-PET_HCT116_Human1.29975948
64AR_25329375_ChIP-Seq_VCAP_Human1.29813044
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29381406
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28543678
67TCF4_23295773_ChIP-Seq_U87_Human1.28087324
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.26981741
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.25211535
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24242460
71AR_21572438_ChIP-Seq_LNCaP_Human1.23347060
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20949089
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.20560552
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19450251
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.18432987
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18374572
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18004438
78EWS_26573619_Chip-Seq_HEK293_Human1.17863298
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17385219
80P53_22387025_ChIP-Seq_ESCs_Mouse1.17169714
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17063250
82RUNX2_22187159_ChIP-Seq_PCA_Human1.15869007
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13334908
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13005408
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12374450
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.12080630
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.11836087
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11240720
89KDM2B_26808549_Chip-Seq_REH_Human1.10499328
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10310072
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10235387
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.09427215
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.09297940
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09086839
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09047158
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.08850814
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.08528129
98TCF4_22108803_ChIP-Seq_LS180_Human1.08316473
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.06845890
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05094260
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04135003
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02714117
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02714117
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00007472
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99439877
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99023732
107RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97525253
108EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97525253
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97367330
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95626297
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93108043
112HNF4A_19822575_ChIP-Seq_HepG2_Human0.90968206
113EZH2_27294783_Chip-Seq_ESCs_Mouse0.89482487
114SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88297202
115REST_18959480_ChIP-ChIP_MESCs_Mouse0.86223625
116RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85344300
117LXR_22292898_ChIP-Seq_THP-1_Human0.85114235
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84942838
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84784132
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84427587
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83576751
122TAF15_26573619_Chip-Seq_HEK293_Human0.82387330
123GBX2_23144817_ChIP-Seq_PC3_Human0.82329461
124JARID2_20064375_ChIP-Seq_MESCs_Mouse0.80074903
125REST_21632747_ChIP-Seq_MESCs_Mouse0.74812465
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.74372488
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73065171
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.72076126
129EZH2_27304074_Chip-Seq_ESCs_Mouse0.71690460
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71119642
131CTCF_27219007_Chip-Seq_Bcells_Human0.70561788
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70038664
133BCAT_22108803_ChIP-Seq_LS180_Human0.68061292
134EOMES_21245162_ChIP-Seq_HESCs_Human0.67609775
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67167139
136ZNF274_21170338_ChIP-Seq_K562_Hela0.67039211
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.66782438
138SOX2_20726797_ChIP-Seq_SW620_Human0.66764667
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65619937
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.65404865
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64925254
142STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.64172588
143ESR2_21235772_ChIP-Seq_MCF-7_Human0.63475272
144DROSHA_22980978_ChIP-Seq_HELA_Human0.62490782
145EGR1_19032775_ChIP-ChIP_M12_Human0.62361555
146CTBP1_25329375_ChIP-Seq_LNCAP_Human0.61886658
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61213676
148GATA1_22025678_ChIP-Seq_K562_Human0.61144965
149ZNF263_19887448_ChIP-Seq_K562_Human0.60642446
150AR_20517297_ChIP-Seq_VCAP_Human0.60291110
151RARB_24833708_ChIP-Seq_LIVER_Mouse0.58905676
152SOX2_27498859_Chip-Seq_STOMACH_Mouse0.58042426
153MYC_19915707_ChIP-ChIP_AK7_Human0.57701441
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.57005527
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.56513629
156NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55696045
157PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.55262903
158GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54783757
159CBP_21632823_ChIP-Seq_H3396_Human0.54637044
160CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.54065129
161GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.53569702
162CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.52869796
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.52576228
164TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.52327732
165RARA_24833708_ChIP-Seq_LIVER_Mouse0.52294695
166P53_21459846_ChIP-Seq_SAOS-2_Human0.52089910
167CBP_20019798_ChIP-Seq_JUKART_Human0.51978782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.12734273
2MP0005360_urolithiasis6.26230014
3MP0005085_abnormal_gallbladder_physiolo5.27286045
4MP0005365_abnormal_bile_salt5.17454404
5MP0008875_abnormal_xenobiotic_pharmacok4.30601873
6MP0003806_abnormal_nucleotide_metabolis3.51802697
7MP0005503_abnormal_tendon_morphology3.23479085
8MP0003252_abnormal_bile_duct3.14280616
9MP0010329_abnormal_lipoprotein_level3.11907282
10MP0009840_abnormal_foam_cell3.00586011
11MP0003195_calcinosis2.88064412
12MP0005332_abnormal_amino_acid2.80004743
13MP0001958_emphysema2.78423937
14MP0005275_abnormal_skin_tensile2.41424418
15MP0000569_abnormal_digit_pigmentation2.39019135
16MP0001666_abnormal_nutrient_absorption2.34639225
17MP0005083_abnormal_biliary_tract2.27662519
18MP0003950_abnormal_plasma_membrane2.15257677
19MP0003279_aneurysm2.12877373
20MP0004272_abnormal_basement_membrane2.12282329
21MP0006054_spinal_hemorrhage2.04542697
22MP0002118_abnormal_lipid_homeostasis1.96181550
23MP0003191_abnormal_cellular_cholesterol1.86547691
24MP0009046_muscle_twitch1.86183194
25MP0004885_abnormal_endolymph1.80206514
26MP0004019_abnormal_vitamin_homeostasis1.75989323
27MP0001968_abnormal_touch/_nociception1.70543453
28MP0003329_amyloid_beta_deposits1.68369815
29MP0000609_abnormal_liver_physiology1.67428451
30MP0001764_abnormal_homeostasis1.66078830
31MP0001542_abnormal_bone_strength1.65990185
32MP0003868_abnormal_feces_composition1.62460733
33MP0005584_abnormal_enzyme/coenzyme_acti1.61271780
34MP0005319_abnormal_enzyme/_coenzyme1.59895339
35MP0000749_muscle_degeneration1.58822253
36MP0009745_abnormal_behavioral_response1.55532822
37MP0002138_abnormal_hepatobiliary_system1.55362130
38MP0003283_abnormal_digestive_organ1.55081723
39MP0000751_myopathy1.54469957
40MP0002735_abnormal_chemical_nociception1.48731832
41MP0002734_abnormal_mechanical_nocicepti1.46124968
42MP0002837_dystrophic_cardiac_calcinosis1.45963285
43MP0000604_amyloidosis1.44632127
44MP0004145_abnormal_muscle_electrophysio1.40440076
45MP0001299_abnormal_eye_distance/1.40270145
46MP0002572_abnormal_emotion/affect_behav1.37332192
47MP0002108_abnormal_muscle_morphology1.34003784
48MP0003011_delayed_dark_adaptation1.32779201
49MP0005423_abnormal_somatic_nervous1.32497757
50MP0009643_abnormal_urine_homeostasis1.28885745
51MP0005623_abnormal_meninges_morphology1.28867814
52MP0000778_abnormal_nervous_system1.28783037
53MP0005535_abnormal_body_temperature1.27157512
54MP0002102_abnormal_ear_morphology1.26985056
55MP0001970_abnormal_pain_threshold1.26302098
56MP0002063_abnormal_learning/memory/cond1.25901517
57MP0001986_abnormal_taste_sensitivity1.25878678
58MP0004215_abnormal_myocardial_fiber1.25599735
59MP0002876_abnormal_thyroid_physiology1.24994732
60MP0003186_abnormal_redox_activity1.24097213
61MP0005084_abnormal_gallbladder_morpholo1.22378198
62MP0003045_fibrosis1.17955525
63MP0001879_abnormal_lymphatic_vessel1.17429662
64MP0001984_abnormal_olfaction1.17120928
65MP0005386_behavior/neurological_phenoty1.17036469
66MP0004924_abnormal_behavior1.17036469
67MP0001486_abnormal_startle_reflex1.16925845
68MP0005058_abnormal_lysosome_morphology1.16812031
69MP0006036_abnormal_mitochondrial_physio1.15035420
70MP0004084_abnormal_cardiac_muscle1.14252979
71MP0009697_abnormal_copulation1.12572443
72MP0000427_abnormal_hair_cycle1.12005061
73MP0004484_altered_response_of1.11335821
74MP0005636_abnormal_mineral_homeostasis1.11295973
75MP0008775_abnormal_heart_ventricle1.10714672
76MP0005508_abnormal_skeleton_morphology1.10310633
77MP0002909_abnormal_adrenal_gland1.09725318
78MP0002733_abnormal_thermal_nociception1.07830415
79MP0005187_abnormal_penis_morphology1.07351324
80MP0005171_absent_coat_pigmentation1.06716467
81MP0005620_abnormal_muscle_contractility1.06319761
82MP0002184_abnormal_innervation1.05072507
83MP0002078_abnormal_glucose_homeostasis1.04882469
84MP0005253_abnormal_eye_physiology1.04083508
85MP0000013_abnormal_adipose_tissue1.03809004
86MP0002168_other_aberrant_phenotype1.03363966
87MP0004858_abnormal_nervous_system1.02986257
88MP0005220_abnormal_exocrine_pancreas1.02734758
89MP0002557_abnormal_social/conspecific_i1.01311537
90MP0002067_abnormal_sensory_capabilities1.00751780
91MP0004130_abnormal_muscle_cell0.98838620
92MP0010368_abnormal_lymphatic_system0.96223448
93MP0002090_abnormal_vision0.94158317
94MP0006072_abnormal_retinal_apoptosis0.94157176
95MP0003787_abnormal_imprinting0.93825976
96MP0002254_reproductive_system_inflammat0.91861125
97MP0004134_abnormal_chest_morphology0.91451345
98MP0000767_abnormal_smooth_muscle0.90898725
99MP0003690_abnormal_glial_cell0.89500121
100MP0003122_maternal_imprinting0.89081190
101MP0009250_abnormal_appendicular_skeleto0.88646766
102MP0005451_abnormal_body_composition0.88593971
103MP0004043_abnormal_pH_regulation0.88354236
104MP0005376_homeostasis/metabolism_phenot0.88284376
105MP0005670_abnormal_white_adipose0.88188042
106MP0004036_abnormal_muscle_relaxation0.87505112
107MP0006276_abnormal_autonomic_nervous0.87271512
108MP0003646_muscle_fatigue0.84838259
109MP0000955_abnormal_spinal_cord0.84100889
110MP0000598_abnormal_liver_morphology0.83438954
111MP0006035_abnormal_mitochondrial_morpho0.82960388
112MP0009642_abnormal_blood_homeostasis0.82088605
113MP0003633_abnormal_nervous_system0.81972991
114MP0005551_abnormal_eye_electrophysiolog0.81611220
115MP0002896_abnormal_bone_mineralization0.81569362
116MP0009384_cardiac_valve_regurgitation0.80833371
117MP0003705_abnormal_hypodermis_morpholog0.80802901
118MP0009764_decreased_sensitivity_to0.80243773
119MP0002971_abnormal_brown_adipose0.77777682
120MP0001501_abnormal_sleep_pattern0.77586626
121MP0005448_abnormal_energy_balance0.77413231
122MP0003137_abnormal_impulse_conducting0.75578204
123MP0000534_abnormal_ureter_morphology0.75447905
124MP0005257_abnormal_intraocular_pressure0.75140789
125MP0001440_abnormal_grooming_behavior0.74914290
126MP0000639_abnormal_adrenal_gland0.74903242
127MP0002882_abnormal_neuron_morphology0.73785958
128MP0004085_abnormal_heartbeat0.73486992
129MP0001177_atelectasis0.73136011
130MP0008438_abnormal_cutaneous_collagen0.72054468
131MP0001756_abnormal_urination0.71607271
132MP0000230_abnormal_systemic_arterial0.71033846
133MP0003959_abnormal_lean_body0.71033465
134MP0004742_abnormal_vestibular_system0.70493533
135MP0005369_muscle_phenotype0.70352675
136MP0004510_myositis0.69309922
137MP0005647_abnormal_sex_gland0.68748353
138MP0003656_abnormal_erythrocyte_physiolo0.68036819
139MP0005266_abnormal_metabolism0.68019836
140MP0005595_abnormal_vascular_smooth0.67341725
141MP0003075_altered_response_to0.64307385
142MP0003953_abnormal_hormone_level0.63819823
143MP0005334_abnormal_fat_pad0.63705130
144MP0008469_abnormal_protein_level0.62521229
145MP0001944_abnormal_pancreas_morphology0.62011659
146MP0001661_extended_life_span0.60967613
147MP0002928_abnormal_bile_duct0.60675089
148MP0000538_abnormal_urinary_bladder0.59599918
149MP0010234_abnormal_vibrissa_follicle0.58738359
150MP0003638_abnormal_response/metabolism_0.57699739
151MP0003635_abnormal_synaptic_transmissio0.57361437
152MP0009763_increased_sensitivity_to0.56854931
153MP0003880_abnormal_central_pattern0.56576764
154MP0002736_abnormal_nociception_after0.56344775
155MP0009780_abnormal_chondrocyte_physiolo0.55441550
156MP0001529_abnormal_vocalization0.55154217
157MP0002295_abnormal_pulmonary_circulatio0.54576317
158MP0010386_abnormal_urinary_bladder0.53998654
159MP0004859_abnormal_synaptic_plasticity0.53831487
160MP0001502_abnormal_circadian_rhythm0.53361442
161MP0002069_abnormal_eating/drinking_beha0.51937463
162MP0008874_decreased_physiological_sensi0.51322290
163MP0005645_abnormal_hypothalamus_physiol0.49892104
164MP0002064_seizures0.49498407
165MP0004142_abnormal_muscle_tone0.49321986
166MP0004270_analgesia0.48924659
167MP0005164_abnormal_response_to0.47919297
168MP0002272_abnormal_nervous_system0.46145981
169MP0001765_abnormal_ion_homeostasis0.45617907
170MP0003879_abnormal_hair_cell0.43525902

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.57408029
2Deep venous thrombosis (HP:0002625)5.62249813
3Intrahepatic cholestasis (HP:0001406)5.58227788
4Xanthomatosis (HP:0000991)5.18485831
5Hypobetalipoproteinemia (HP:0003563)4.89185075
6Prolonged partial thromboplastin time (HP:0003645)4.78785777
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.74221085
8Hyperlipoproteinemia (HP:0010980)4.56345704
9Premature rupture of membranes (HP:0001788)4.46763199
10Ketosis (HP:0001946)4.42971037
11Complement deficiency (HP:0004431)4.27524918
12Hyperammonemia (HP:0001987)4.04669606
13Hyperglycinemia (HP:0002154)4.01491000
14Follicular hyperkeratosis (HP:0007502)3.89581675
15Hypoglycemic coma (HP:0001325)3.81000568
16Hypolipoproteinemia (HP:0010981)3.78380202
17Ketoacidosis (HP:0001993)3.74718869
18Abnormality of glycine metabolism (HP:0010895)3.69800753
19Abnormality of serine family amino acid metabolism (HP:0010894)3.69800753
20Hyperglycinuria (HP:0003108)3.65400614
21Soft skin (HP:0000977)3.63624689
22Aortic dissection (HP:0002647)3.62653887
23Abnormality of the common coagulation pathway (HP:0010990)3.54069954
24Hyperventilation (HP:0002883)3.41386108
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.40911842
26Hypoalphalipoproteinemia (HP:0003233)3.39358216
27Abnormality of the intrinsic pathway (HP:0010989)3.39278238
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.38828227
29Protrusio acetabuli (HP:0003179)3.36210568
30Fat malabsorption (HP:0002630)3.28574338
31Epidermoid cyst (HP:0200040)3.21755875
32Type II lissencephaly (HP:0007260)3.21234795
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.20910073
34Abnormality of fatty-acid metabolism (HP:0004359)3.19626226
35Vascular tortuosity (HP:0004948)3.19083037
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.14191126
37Joint hemorrhage (HP:0005261)3.10604835
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.10097021
39Cerebral edema (HP:0002181)3.06161933
40Keratoconus (HP:0000563)3.01332332
41Increased corneal curvature (HP:0100692)3.01332332
42Abnormality of methionine metabolism (HP:0010901)2.99611867
43Abnormality of complement system (HP:0005339)2.94091796
44Type 1 muscle fiber predominance (HP:0003803)2.89634503
45Conjugated hyperbilirubinemia (HP:0002908)2.88282312
46Abnormality of serum amino acid levels (HP:0003112)2.84825870
47Aortic aneurysm (HP:0004942)2.84720669
48Gout (HP:0001997)2.84208763
49Absent speech (HP:0001344)2.81346079
50Arterial tortuosity (HP:0005116)2.79733607
51Delayed CNS myelination (HP:0002188)2.79322304
52Focal motor seizures (HP:0011153)2.79115241
53Lethargy (HP:0001254)2.78450277
54Abnormality of midbrain morphology (HP:0002418)2.77662863
55Molar tooth sign on MRI (HP:0002419)2.77662863
56Broad metatarsal (HP:0001783)2.71780948
57Hypercholesterolemia (HP:0003124)2.70228697
58Focal seizures (HP:0007359)2.69497674
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68588570
60Dicarboxylic aciduria (HP:0003215)2.68588570
61Gaze-evoked nystagmus (HP:0000640)2.67623890
62Febrile seizures (HP:0002373)2.66648797
63Metabolic acidosis (HP:0001942)2.66483064
64Abnormality of dentin (HP:0010299)2.65572182
65Pancreatic fibrosis (HP:0100732)2.64135872
66Hyperbilirubinemia (HP:0002904)2.61725462
67Skin nodule (HP:0200036)2.58634367
68Pancreatic cysts (HP:0001737)2.58189038
69Hypoglycemic seizures (HP:0002173)2.58125341
70Hemiparesis (HP:0001269)2.55084853
71Steatorrhea (HP:0002570)2.53762879
72Acute encephalopathy (HP:0006846)2.53006214
73Medial flaring of the eyebrow (HP:0010747)2.50725550
74Atonic seizures (HP:0010819)2.49583734
75Abnormality of the calf musculature (HP:0001430)2.49474842
76Bladder diverticulum (HP:0000015)2.47150147
77Delayed gross motor development (HP:0002194)2.46293153
78Gait imbalance (HP:0002141)2.45476517
79Hepatic necrosis (HP:0002605)2.44636383
80Abnormality of purine metabolism (HP:0004352)2.44293473
81Calf muscle hypertrophy (HP:0008981)2.44020707
82Atrophic scars (HP:0001075)2.41917901
83Neonatal short-limb short stature (HP:0008921)2.39154620
84Late onset (HP:0003584)2.37751873
85Cholecystitis (HP:0001082)2.37203570
86Abnormal gallbladder physiology (HP:0012438)2.37203570
87Irritability (HP:0000737)2.35974332
88True hermaphroditism (HP:0010459)2.34660664
89Sensorimotor neuropathy (HP:0007141)2.34295111
90Striae distensae (HP:0001065)2.32245826
91Generalized aminoaciduria (HP:0002909)2.29861905
92Abnormal gallbladder morphology (HP:0012437)2.29768891
93Vomiting (HP:0002013)2.27982544
94Abnormality of nucleobase metabolism (HP:0010932)2.26478251
95Amyloidosis (HP:0011034)2.23263403
96Hepatocellular carcinoma (HP:0001402)2.21098490
97Neonatal onset (HP:0003623)2.20432212
98Brushfield spots (HP:0001088)2.18801139
99Hyperinsulinemic hypoglycemia (HP:0000825)2.18349894
100Cholelithiasis (HP:0001081)2.17443423
101Congenital primary aphakia (HP:0007707)2.17074344
102Systemic lupus erythematosus (HP:0002725)2.16481082
103Genetic anticipation (HP:0003743)2.15598144
104Mitral stenosis (HP:0001718)2.14417513
105Muscle hypertrophy of the lower extremities (HP:0008968)2.14103755
106Congenital stationary night blindness (HP:0007642)2.12494751
107Inability to walk (HP:0002540)2.11527298
108Abnormal mitochondria in muscle tissue (HP:0008316)2.11269037
109Wide anterior fontanel (HP:0000260)2.10254785
110Vascular calcification (HP:0004934)2.10197456
111Ragged-red muscle fibers (HP:0003200)2.09624508
112Spontaneous abortion (HP:0005268)2.08636340
113Broad-based gait (HP:0002136)2.08338694
114Neurofibrillary tangles (HP:0002185)2.07763887
115Myoglobinuria (HP:0002913)2.07548131
116Coronal craniosynostosis (HP:0004440)2.06601674
117Infantile muscular hypotonia (HP:0008947)2.05476644
118Progressive cerebellar ataxia (HP:0002073)2.05380373
119Hepatocellular necrosis (HP:0001404)2.04674341
120Wormian bones (HP:0002645)2.03717034
121Pancreatitis (HP:0001733)2.03570919
122Ankle contracture (HP:0006466)2.02632376
123Chronic hepatic failure (HP:0100626)2.01800095
124Polyphagia (HP:0002591)2.01711136
125Glomerulonephritis (HP:0000099)2.00971243
126Opisthotonus (HP:0002179)2.00255009
127Drooling (HP:0002307)2.00121753
128Aortic regurgitation (HP:0001659)1.98758678
129Abnormality of urine glucose concentration (HP:0011016)1.98694066
130Glycosuria (HP:0003076)1.98694066
131Nephrogenic diabetes insipidus (HP:0009806)1.97509954
132Fair hair (HP:0002286)1.96924843
133Cardiovascular calcification (HP:0011915)1.96776002
134Malnutrition (HP:0004395)1.96625938
135Acute necrotizing encephalopathy (HP:0006965)1.96205205
136Action tremor (HP:0002345)1.95181541
137Overgrowth (HP:0001548)1.94217818
138Arthropathy (HP:0003040)1.93740743
139Methylmalonic aciduria (HP:0012120)1.93140590
140Abnormality of proline metabolism (HP:0010907)1.92994333
141Hydroxyprolinuria (HP:0003080)1.92994333
142Prolonged QT interval (HP:0001657)1.92808776
143Hyperextensible skin (HP:0000974)1.92289598
144Large for gestational age (HP:0001520)1.92190261
145Broad ribs (HP:0000885)1.90907772
146Abnormality of pyrimidine metabolism (HP:0004353)1.90847809
147Abnormality of the gallbladder (HP:0005264)1.89591830
148Genital tract atresia (HP:0001827)1.89426893
149Progressive inability to walk (HP:0002505)1.88641646
150Limited hip movement (HP:0008800)1.88220883
151Myocardial infarction (HP:0001658)1.87775584
152Bowel diverticulosis (HP:0005222)1.87745559
153Hemiplegia (HP:0002301)1.87152800
154Abnormality of the Achilles tendon (HP:0005109)1.86602830
155Slender build (HP:0001533)1.85846233
156Short foot (HP:0001773)1.85778112
157Increased muscle lipid content (HP:0009058)1.85184044
158Facial diplegia (HP:0001349)1.84111629
159Neuroendocrine neoplasm (HP:0100634)1.83526692
160Fetal akinesia sequence (HP:0001989)1.83222377
161Vaginal atresia (HP:0000148)1.83154302
162Abnormal cartilage morphology (HP:0002763)1.82754975
163Generalized tonic-clonic seizures (HP:0002069)1.81277069
164Craniofacial dystonia (HP:0012179)1.81074320
165Spastic diplegia (HP:0001264)1.80717643
166Metaphyseal dysplasia (HP:0100255)1.80408718
167Status epilepticus (HP:0002133)1.79909026
168Dialeptic seizures (HP:0011146)1.79342372
169Abnormality of glycolysis (HP:0004366)1.78877710
170Increased serum pyruvate (HP:0003542)1.78877710
171Alkalosis (HP:0001948)1.78162995
172Symptomatic seizures (HP:0011145)1.78015690
173Cerebral inclusion bodies (HP:0100314)1.77771380
174Lactic acidosis (HP:0003128)1.77309210
175Excessive salivation (HP:0003781)1.76537420
176Absence seizures (HP:0002121)1.76400100
177Hypoventilation (HP:0002791)1.76165396
178Nephronophthisis (HP:0000090)1.75774110
179Cystic liver disease (HP:0006706)1.75183905
180Left ventricular hypertrophy (HP:0001712)1.73781628
181Congenital sensorineural hearing impairment (HP:0008527)1.73025476
182Round ear (HP:0100830)1.72551227
183Aplasia/Hypoplasia of the lens (HP:0008063)1.72508030
184Agitation (HP:0000713)1.70515385
185Limb-girdle muscle weakness (HP:0003325)1.69962739
186Mild short stature (HP:0003502)1.69466904
187Bundle branch block (HP:0011710)1.68499915
188Cerebellar dysplasia (HP:0007033)1.67032053
189Shallow orbits (HP:0000586)1.66079713
190Thyroid-stimulating hormone excess (HP:0002925)1.65650956
191Bulbous nose (HP:0000414)1.65333942
192Chorioretinal atrophy (HP:0000533)1.64837578
193Peritonitis (HP:0002586)1.64636525
194Postaxial hand polydactyly (HP:0001162)1.64497207
195Genu recurvatum (HP:0002816)1.62127383
196Atrial fibrillation (HP:0005110)1.61978275
197Abnormality of the renal medulla (HP:0100957)1.61937007
198Hip contracture (HP:0003273)1.61410787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.17023972
2ERN13.92248881
3CASK3.69868103
4INSRR3.13841166
5ARAF3.02159591
6FGFR42.80410623
7SIK12.18530699
8ADRBK21.99852871
9TRIB31.77742067
10MAP3K91.72349973
11AKT31.71429768
12MAP3K131.70918828
13ACVR1B1.70327848
14GRK11.64031036
15MAP2K41.60469368
16EPHA41.53767183
17PAK31.50557465
18TNIK1.46805549
19ERBB41.43964477
20GRK71.41579156
21BMPR1B1.40729405
22STK161.40721091
23NTRK11.40169603
24PKN21.38176182
25MAPK131.37364366
26PRKCE1.37350275
27PLK21.36984172
28EPHA31.35939610
29ADRBK11.35602761
30FLT31.32266410
31KSR21.32175026
32LMTK21.30348225
33OBSCN1.29289874
34ERBB31.25702043
35NTRK31.21719487
36FGFR21.20027035
37KSR11.17884919
38STK391.17870529
39PINK11.17204993
40CAMK2G1.14347682
41MYLK1.14305218
42MINK11.13751517
43MAPK151.13549293
44PHKG21.12468399
45PHKG11.12468399
46TRPM71.09161794
47PIK3CG1.07656346
48MAP4K21.06839847
49NEK91.03781968
50BRAF1.03470238
51STK38L1.03260453
52TLK11.03010227
53ABL21.02976570
54CSNK1G31.01276882
55KDR1.00799145
56TIE10.99962676
57SGK20.96912695
58NLK0.94216157
59MAP3K60.93117916
60OXSR10.90894080
61DAPK20.90877233
62DDR20.90394985
63FER0.89565854
64CSNK1G20.88396352
65PNCK0.88233674
66MAP2K10.84447635
67NUAK10.83848051
68PTK60.83588622
69PRKCG0.82908800
70GRK50.82013979
71TAOK30.81441169
72BCR0.80681825
73ROCK10.80400136
74DYRK1B0.79444941
75ZAK0.79150131
76RAF10.78673348
77LATS10.78626722
78PTK20.78582697
79CAMKK20.77331632
80SGK2230.77127863
81SGK4940.77127863
82MARK10.76500822
83PRKD30.76233728
84STK380.75907490
85RIPK10.75189306
86MUSK0.74851338
87CSNK1G10.74323341
88MAP3K120.73492074
89PRKCZ0.71418767
90MAP3K40.70968050
91MAPK110.70244279
92PIK3CA0.70235923
93CAMK2A0.69297782
94TYK20.68977667
95WNK40.68796156
96PDGFRA0.68526579
97RET0.68091908
98NTRK20.65314901
99PAK60.64665606
100SCYL20.62589166
101TBK10.62520252
102CDK50.62479077
103PDK20.62020444
104MAPK70.61797806
105MAP3K110.61647918
106CAMK2B0.61562492
107MAP3K70.61172958
108JAK20.61074575
109LIMK10.60992042
110TGFBR20.59994461
111CAMK2D0.57751211
112WNK30.57683818
113PDGFRB0.57542947
114PRKACG0.57310217
115FRK0.56535876
116MAP2K70.55489918
117DYRK1A0.55198465
118IRAK20.55113121
119MOS0.54652242
120MST1R0.54594078
121EPHB10.54411884
122MAPK120.54071971
123CSNK1A1L0.53362726
124CAMK10.52918943
125TAOK20.52021361
126MAP3K10.51153868
127PRKCH0.50054219
128GRK60.49810684
129UHMK10.49624716
130NEK10.49575908
131MET0.49377872
132PDPK10.49118953
133MAPKAPK30.48513725
134MAP2K20.47695991
135PTK2B0.47137149
136CAMKK10.46925829
137ROCK20.45693853
138CDK190.45520481
139CDK140.44827165
140JAK10.44454505
141KIT0.43722203
142PRKG10.43516252
143TESK10.43321528
144PRKAA20.43211823
145GSK3A0.43099769
146PKN10.42954234
147PRKACA0.42790001
148FGFR10.42498869
149EPHB20.42242065
150PDK40.41638016
151PDK30.41638016
152SGK30.38553530

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99721495
2Nitrogen metabolism_Homo sapiens_hsa009103.45317055
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95550609
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74061180
5Arginine biosynthesis_Homo sapiens_hsa002202.65904328
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60843171
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59399124
8Fatty acid degradation_Homo sapiens_hsa000712.56181619
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53207352
10Tryptophan metabolism_Homo sapiens_hsa003802.51401461
11Butanoate metabolism_Homo sapiens_hsa006502.39410847
12Complement and coagulation cascades_Homo sapiens_hsa046102.26055578
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23279015
14Propanoate metabolism_Homo sapiens_hsa006402.21259846
15Peroxisome_Homo sapiens_hsa041462.03511690
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03366941
17Fatty acid metabolism_Homo sapiens_hsa012121.96400044
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85368778
19Sulfur metabolism_Homo sapiens_hsa009201.79297353
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75845143
21PPAR signaling pathway_Homo sapiens_hsa033201.74861860
22ECM-receptor interaction_Homo sapiens_hsa045121.74543834
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73314449
24Morphine addiction_Homo sapiens_hsa050321.73096169
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72962735
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70344281
27Dilated cardiomyopathy_Homo sapiens_hsa054141.67293680
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66829163
29Histidine metabolism_Homo sapiens_hsa003401.64302744
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63828996
31Chemical carcinogenesis_Homo sapiens_hsa052041.60028300
32Pyruvate metabolism_Homo sapiens_hsa006201.58818567
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58544733
34Glutamatergic synapse_Homo sapiens_hsa047241.57445189
35Fatty acid elongation_Homo sapiens_hsa000621.55479120
36beta-Alanine metabolism_Homo sapiens_hsa004101.52822764
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51498319
38Circadian entrainment_Homo sapiens_hsa047131.50101243
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.49844310
40Bile secretion_Homo sapiens_hsa049761.49405477
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.48727711
42Phenylalanine metabolism_Homo sapiens_hsa003601.46890228
43Circadian rhythm_Homo sapiens_hsa047101.41511220
44Caffeine metabolism_Homo sapiens_hsa002321.38611241
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34275029
46Tyrosine metabolism_Homo sapiens_hsa003501.34194528
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.34173241
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32940330
49Protein digestion and absorption_Homo sapiens_hsa049741.31135565
50Renin secretion_Homo sapiens_hsa049241.28168358
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27579938
52Starch and sucrose metabolism_Homo sapiens_hsa005001.26783710
53Carbon metabolism_Homo sapiens_hsa012001.25866266
54Dopaminergic synapse_Homo sapiens_hsa047281.24941915
55Phototransduction_Homo sapiens_hsa047441.24738004
56Retinol metabolism_Homo sapiens_hsa008301.24240630
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23181283
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21985966
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21644496
60Linoleic acid metabolism_Homo sapiens_hsa005911.17140912
61Biosynthesis of amino acids_Homo sapiens_hsa012301.15883245
62Salivary secretion_Homo sapiens_hsa049701.15482903
63Folate biosynthesis_Homo sapiens_hsa007901.15358758
64Selenocompound metabolism_Homo sapiens_hsa004501.12175352
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11904015
66Taste transduction_Homo sapiens_hsa047421.11779336
67Staphylococcus aureus infection_Homo sapiens_hsa051501.09150248
68Vascular smooth muscle contraction_Homo sapiens_hsa042701.08318497
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05692816
70cAMP signaling pathway_Homo sapiens_hsa040241.04444530
71Amphetamine addiction_Homo sapiens_hsa050311.03647575
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03432031
73Cysteine and methionine metabolism_Homo sapiens_hsa002701.03291107
74Arginine and proline metabolism_Homo sapiens_hsa003301.03244966
75Calcium signaling pathway_Homo sapiens_hsa040201.02819804
76Axon guidance_Homo sapiens_hsa043601.01168578
77Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01078273
78Mineral absorption_Homo sapiens_hsa049781.00361208
79Serotonergic synapse_Homo sapiens_hsa047260.99298939
80Oxytocin signaling pathway_Homo sapiens_hsa049210.99152940
81Ether lipid metabolism_Homo sapiens_hsa005650.98396098
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97275050
83Sulfur relay system_Homo sapiens_hsa041220.96654530
84Fat digestion and absorption_Homo sapiens_hsa049750.93545481
85Gastric acid secretion_Homo sapiens_hsa049710.92638172
86Hedgehog signaling pathway_Homo sapiens_hsa043400.92189150
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91955488
88Cholinergic synapse_Homo sapiens_hsa047250.91468024
89ABC transporters_Homo sapiens_hsa020100.91309836
90Focal adhesion_Homo sapiens_hsa045100.90999292
91Steroid biosynthesis_Homo sapiens_hsa001000.90196332
92Long-term depression_Homo sapiens_hsa047300.87672159
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82654725
94Dorso-ventral axis formation_Homo sapiens_hsa043200.81500602
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.79945780
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78064431
97Ovarian steroidogenesis_Homo sapiens_hsa049130.77694330
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74844919
99Vitamin B6 metabolism_Homo sapiens_hsa007500.74801937
100Vitamin digestion and absorption_Homo sapiens_hsa049770.74444606
101Oxidative phosphorylation_Homo sapiens_hsa001900.74249734
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70493664
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66853308
104Hippo signaling pathway_Homo sapiens_hsa043900.66689595
105Prion diseases_Homo sapiens_hsa050200.66091516
106Ras signaling pathway_Homo sapiens_hsa040140.62350479
107Pancreatic secretion_Homo sapiens_hsa049720.61929268
108Glycerolipid metabolism_Homo sapiens_hsa005610.60937111
109TGF-beta signaling pathway_Homo sapiens_hsa043500.59582137
110Sphingolipid metabolism_Homo sapiens_hsa006000.58838691
111Parkinsons disease_Homo sapiens_hsa050120.57091984
112Metabolic pathways_Homo sapiens_hsa011000.56665106
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56514332
114Basal cell carcinoma_Homo sapiens_hsa052170.56486189
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55512369
116Protein export_Homo sapiens_hsa030600.55190486
117Olfactory transduction_Homo sapiens_hsa047400.55013164
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54809195
119Glutathione metabolism_Homo sapiens_hsa004800.54190137
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53618630
121Melanogenesis_Homo sapiens_hsa049160.52873089
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52703829
123Fatty acid biosynthesis_Homo sapiens_hsa000610.50747985
124GABAergic synapse_Homo sapiens_hsa047270.49941752
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49611842
126Renin-angiotensin system_Homo sapiens_hsa046140.48072057
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45615684
128Galactose metabolism_Homo sapiens_hsa000520.42824461
129Alzheimers disease_Homo sapiens_hsa050100.42322742
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41763150
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41198261
132Pentose phosphate pathway_Homo sapiens_hsa000300.39489122
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30568211
134Fructose and mannose metabolism_Homo sapiens_hsa000510.29210303
135Lysosome_Homo sapiens_hsa041420.28818935
136Synaptic vesicle cycle_Homo sapiens_hsa047210.28359537
137Insulin secretion_Homo sapiens_hsa049110.23897234
138Lysine degradation_Homo sapiens_hsa003100.22126502
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21903404
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21386842
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.20994950
142Vibrio cholerae infection_Homo sapiens_hsa051100.20634776
143Glucagon signaling pathway_Homo sapiens_hsa049220.19881507
144Nicotine addiction_Homo sapiens_hsa050330.18941722
145Thyroid hormone synthesis_Homo sapiens_hsa049180.18240084
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.17441615
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16505232
148Insulin resistance_Homo sapiens_hsa049310.16369559
149Collecting duct acid secretion_Homo sapiens_hsa049660.12244160
150Cardiac muscle contraction_Homo sapiens_hsa042600.11981670
151Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10624360
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.10290291
153Huntingtons disease_Homo sapiens_hsa050160.07652540
154Regulation of autophagy_Homo sapiens_hsa041400.06724829
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.05637738
156Cocaine addiction_Homo sapiens_hsa050300.05081755
157N-Glycan biosynthesis_Homo sapiens_hsa005100.04780595

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