ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	5.75314916
2	ribosomal small subunit biogenesis (GO:0042274)	5.73794786
3	translational termination (GO:0006415)	5.50679367
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.37610021
5	cotranslational protein targeting to membrane (GO:0006613)	5.36956866
6	protein targeting to ER (GO:0045047)	5.32387628
7	ribosomal small subunit assembly (GO:0000028)	5.25757300
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.06964512
9	protein localization to endoplasmic reticulum (GO:0070972)	5.04483589
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.87580821
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.84748034
12	ATP synthesis coupled proton transport (GO:0015986)	4.84748034
13	protein neddylation (GO:0045116)	4.74496397
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.58875049
15	viral life cycle (GO:0019058)	4.53422704
16	translational elongation (GO:0006414)	4.45802830
17	neutrophil activation involved in immune response (GO:0002283)	4.32571283
18	cellular protein complex disassembly (GO:0043624)	4.29534255
19	ribosomal large subunit biogenesis (GO:0042273)	4.24828256
20	CENP-A containing nucleosome assembly (GO:0034080)	4.10016314
21	chromatin remodeling at centromere (GO:0031055)	4.08846866
22	rRNA modification (GO:0000154)	4.06619808
23	respiratory electron transport chain (GO:0022904)	4.06571790
24	regulation of mitochondrial translation (GO:0070129)	4.05966858
25	establishment of integrated proviral latency (GO:0075713)	3.99530225
26	electron transport chain (GO:0022900)	3.96400444
27	maturation of SSU-rRNA (GO:0030490)	3.95132070
28	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.94933502
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.89729413
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.86825494
31	respiratory chain complex IV assembly (GO:0008535)	3.78023933
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.77742540
33	translational initiation (GO:0006413)	3.74790251
34	protein targeting to membrane (GO:0006612)	3.67095588
35	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.65067891
36	spliceosomal snRNP assembly (GO:0000387)	3.64941949
37	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.62937442
38	ATP biosynthetic process (GO:0006754)	3.61500398
39	signal peptide processing (GO:0006465)	3.61016853
40	translation (GO:0006412)	3.59576940
41	cullin deneddylation (GO:0010388)	3.58066187
42	cytochrome complex assembly (GO:0017004)	3.54868372
43	establishment of protein localization to mitochondrion (GO:0072655)	3.53040040
44	protein localization to mitochondrion (GO:0070585)	3.52747931
45	proteasome assembly (GO:0043248)	3.49960240
46	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.49616522
47	cellular component biogenesis (GO:0044085)	3.48658041
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.46828377
49	DNA damage response, detection of DNA damage (GO:0042769)	3.45141655
50	protein complex disassembly (GO:0043241)	3.42862436
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.41605358
52	regulation of activation of Janus kinase activity (GO:0010533)	3.39057215
53	establishment of viral latency (GO:0019043)	3.37317349
54	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.36514323
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.36514323
56	positive regulation of ligase activity (GO:0051351)	3.34215372
57	oxidative phosphorylation (GO:0006119)	3.33418811
58	rRNA methylation (GO:0031167)	3.32159407
59	aldehyde catabolic process (GO:0046185)	3.32051017
60	histone exchange (GO:0043486)	3.29156171
61	pseudouridine synthesis (GO:0001522)	3.26520713
62	protein deneddylation (GO:0000338)	3.24662591
63	chaperone-mediated protein transport (GO:0072321)	3.23190730
64	macromolecular complex disassembly (GO:0032984)	3.23115515
65	rRNA processing (GO:0006364)	3.22291580
66	sequestering of actin monomers (GO:0042989)	3.20550431
67	7-methylguanosine mRNA capping (GO:0006370)	3.19822411
68	water-soluble vitamin biosynthetic process (GO:0042364)	3.19747335
69	DNA replication checkpoint (GO:0000076)	3.17975544
70	positive regulation of monocyte chemotaxis (GO:0090026)	3.13738840
71	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.12040013
72	RNA capping (GO:0036260)	3.11813662
73	7-methylguanosine RNA capping (GO:0009452)	3.11813662
74	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.11438624
75	DNA replication-independent nucleosome organization (GO:0034724)	3.11258940
76	DNA replication-independent nucleosome assembly (GO:0006336)	3.11258940
77	regulation of cellular amino acid metabolic process (GO:0006521)	3.11042950
78	rRNA metabolic process (GO:0016072)	3.07708699
79	intracellular protein transmembrane import (GO:0044743)	3.07677205
80	inner mitochondrial membrane organization (GO:0007007)	3.05848813
81	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.05094184
82	eosinophil chemotaxis (GO:0048245)	3.04222469
83	mitochondrial transport (GO:0006839)	3.04070963
84	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	3.04041438
85	kinetochore assembly (GO:0051382)	3.04012025
86	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.97088601
87	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.97088601
88	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.93404822
89	termination of RNA polymerase III transcription (GO:0006386)	2.93404822
90	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.93096933
91	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.93038674
92	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.93038674
93	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.93038674
94	protein complex biogenesis (GO:0070271)	2.80279625
95	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.79492131
96	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.78408835
97	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.78408835
98	GPI anchor biosynthetic process (GO:0006506)	2.75946721
99	regulation of metalloenzyme activity (GO:0048552)	2.75667517
100	amyloid precursor protein catabolic process (GO:0042987)	2.74547124
101	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.74100165
102	NADH dehydrogenase complex assembly (GO:0010257)	2.74100165
103	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.74100165
104	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.73703083
105	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.73460198
106	negative regulation of ligase activity (GO:0051352)	2.73460198
107	neutrophil activation (GO:0042119)	2.72519953
108	nucleotide transmembrane transport (GO:1901679)	2.72489274
109	GTP biosynthetic process (GO:0006183)	2.69685540
110	granulocyte activation (GO:0036230)	2.69162000
111	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.68448147
112	eosinophil migration (GO:0072677)	2.66945881
113	establishment of protein localization to membrane (GO:0090150)	2.65531679
114	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.65033407
115	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.62535690
116	fatty acid elongation (GO:0030497)	2.62514662
117	peptidyl-histidine modification (GO:0018202)	2.61889138
118	cholesterol biosynthetic process (GO:0006695)	2.61797670
119	T-helper 1 type immune response (GO:0042088)	2.61749257
120	cellular response to superoxide (GO:0071451)	2.61394269
121	cellular response to oxygen radical (GO:0071450)	2.61394269
122	removal of superoxide radicals (GO:0019430)	2.61394269
123	monocyte chemotaxis (GO:0002548)	2.60140455
124	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.58839495
125	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.57795416
126	respiratory burst (GO:0045730)	2.56309141
127	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.52894427
128	viral protein processing (GO:0019082)	2.50802963
129	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.49244225
130	regulation of T-helper 1 cell differentiation (GO:0045625)	2.49061172
131	protein targeting (GO:0006605)	2.48804112
132	central nervous system myelination (GO:0022010)	2.45633391
133	axon ensheathment in central nervous system (GO:0032291)	2.45633391
134	ribonucleoprotein complex biogenesis (GO:0022613)	2.42667902
135	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.42552199
136	mitochondrial respiratory chain complex assembly (GO:0033108)	2.41830474
137	hydrogen ion transmembrane transport (GO:1902600)	2.41688610
138	protein targeting to mitochondrion (GO:0006626)	2.40709240
139	regulation of cellular amine metabolic process (GO:0033238)	2.40195840
140	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.38470059
141	positive regulation of actin filament depolymerization (GO:0030836)	2.37911256
142	hydrogen peroxide metabolic process (GO:0042743)	2.37767684
143	myeloid cell homeostasis (GO:0002262)	2.37705245
144	isoprenoid biosynthetic process (GO:0008299)	2.36893899

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.50833550
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	4.87650633
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.13447414
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.02113254
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.38349908
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.26145184
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.20003298
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.12535065
9	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.02856415
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.94560432
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.91310473
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.89039943
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.87114634
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75325550
15	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.60456655
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.59921411
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.58684790
18	E2F7_22180533_ChIP-Seq_HELA_Human	2.55460190
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.52164237
20	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.50324570
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.45368965
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.40888572
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29786407
24	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.27969346
25	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.11526569
26	ELK1_22589737_ChIP-Seq_MCF10A_Human	2.11040027
27	DCP1A_22483619_ChIP-Seq_HELA_Human	2.03068166
28	* SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01847307
29	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.01717105
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.97491283
31	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.94928482
32	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.93147070
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.90836924
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.89514174
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.87513130
36	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.86195441
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.84324036
38	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.83916273
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.81993405
40	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.77553634
41	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.76931698
42	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.76757418
43	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.71645707
44	XRN2_22483619_ChIP-Seq_HELA_Human	1.65280354
45	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.64987340
46	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.61480135
47	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.55593323
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.55165539
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.51049917
50	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.50784863
51	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49192939
52	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.48112208
53	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.47687228
54	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.47257111
55	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45893792
56	AR_21909140_ChIP-Seq_LNCAP_Human	1.45672770
57	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.43446859
58	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.43101911
59	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.42404285
60	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.33271475
61	EWS_26573619_Chip-Seq_HEK293_Human	1.32174498
62	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.30360437
63	* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27019403
64	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.26693584
65	SPI1_23547873_ChIP-Seq_NB4_Human	1.26547426
66	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.26216620
67	VDR_22108803_ChIP-Seq_LS180_Human	1.24902339
68	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.24317479
69	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.23037071
70	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.20682426
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20178591
72	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.17976223
73	FUS_26573619_Chip-Seq_HEK293_Human	1.17717377
74	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.16096019
75	SOX2_20726797_ChIP-Seq_SW620_Human	1.14627200
76	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.14438010
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.14218723
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13360208
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12562089
80	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.11405057
81	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.11357520
82	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.09330112
83	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.09322520
84	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.09073033
85	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.08832081
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08627642
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.07756969
88	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.06485659
89	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.04379622
90	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.03134706
91	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02192639
92	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.01348994
93	ZNF274_21170338_ChIP-Seq_K562_Hela	1.00181975
94	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99724620
95	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.97683462
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97664008
97	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.95400345
98	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.94901955
99	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.94560767
100	GABP_19822575_ChIP-Seq_HepG2_Human	0.93816576
101	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92739232
102	TFEB_21752829_ChIP-Seq_HELA_Human	0.91248658
103	MYC_18940864_ChIP-ChIP_HL60_Human	0.89312999
104	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.89212204
105	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89024883
106	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88820331
107	KDM5A_27292631_Chip-Seq_BREAST_Human	0.88785969
108	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.87189796
109	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.86499455
110	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.86493774
111	STAT1_20625510_ChIP-Seq_HELA_Human	0.86127413
112	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.85891556
113	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.85891556
114	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.85891556
115	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.85841335
116	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.85397538
117	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.85394102
118	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.85363957
119	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.84831119
120	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.84764117
121	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.84202001
122	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.82956799
123	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.82673408
124	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.79723651
125	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.79260276
126	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.78975022
127	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.78215514
128	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.77900048
129	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.77818735
130	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.77419132
131	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.77369403
132	ELF5_23300383_ChIP-Seq_T47D_Human	0.76104636
133	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.75004685
134	TP53_22573176_ChIP-Seq_HFKS_Human	0.72795435
135	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.72235776
136	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.70944847
137	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.68303445
138	ERG_20517297_ChIP-Seq_VCAP_Human	0.66919104
139	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.65841025

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.57690097
2	MP0002148_abnormal_hypersensitivity_rea	3.54543945
3	MP0003186_abnormal_redox_activity	3.28763146
4	MP0008058_abnormal_DNA_repair	3.23209729
5	MP0004957_abnormal_blastocyst_morpholog	3.15529567
6	MP0002163_abnormal_gland_morphology	3.12963098
7	MP0006292_abnormal_olfactory_placode	3.09696413
8	MP0001835_abnormal_antigen_presentation	3.05333321
9	MP0009785_altered_susceptibility_to	2.90276925
10	MP0003806_abnormal_nucleotide_metabolis	2.90192599
11	MP0003724_increased_susceptibility_to	2.72302110
12	MP0010094_abnormal_chromosome_stability	2.60440364
13	MP0003136_yellow_coat_color	2.56331602
14	MP0008789_abnormal_olfactory_epithelium	2.30923510
15	MP0002277_abnormal_respiratory_mucosa	2.27849693
16	MP0003077_abnormal_cell_cycle	2.27440418
17	MP0003436_decreased_susceptibility_to	2.26237080
18	MP0005000_abnormal_immune_tolerance	2.15896091
19	MP0010030_abnormal_orbit_morphology	2.15331782
20	MP0002138_abnormal_hepatobiliary_system	2.11644144
21	MP0001346_abnormal_lacrimal_gland	2.11067454
22	MP0001348_abnormal_lacrimal_gland	2.09702664
23	MP0003111_abnormal_nucleus_morphology	2.08626631
24	MP0006082_CNS_inflammation	2.08207926
25	MP0003195_calcinosis	2.04966890
26	MP0005408_hypopigmentation	2.04873098
27	MP0005379_endocrine/exocrine_gland_phen	2.03046376
28	MP0005025_abnormal_response_to	2.00655563
29	MP0001529_abnormal_vocalization	1.93896707
30	MP0006072_abnormal_retinal_apoptosis	1.90211220
31	MP0001790_abnormal_immune_system	1.86786270
32	MP0005387_immune_system_phenotype	1.86786270
33	MP0005451_abnormal_body_composition	1.86300652
34	MP0001293_anophthalmia	1.84597545
35	MP0005671_abnormal_response_to	1.83167964
36	MP0000685_abnormal_immune_system	1.81228646
37	MP0003786_premature_aging	1.76316710
38	MP0002419_abnormal_innate_immunity	1.73757881
39	MP0000372_irregular_coat_pigmentation	1.71867517
40	MP0008877_abnormal_DNA_methylation	1.71199588
41	MP0004381_abnormal_hair_follicle	1.68311996
42	MP0005084_abnormal_gallbladder_morpholo	1.65227198
43	MP0002736_abnormal_nociception_after	1.64682193
44	MP0006035_abnormal_mitochondrial_morpho	1.59887067
45	MP0003941_abnormal_skin_development	1.59790855
46	MP0003011_delayed_dark_adaptation	1.59340071
47	MP0008438_abnormal_cutaneous_collagen	1.55541923
48	MP0000920_abnormal_myelination	1.54908123
49	MP0008007_abnormal_cellular_replicative	1.54578391
50	MP0002132_abnormal_respiratory_system	1.52793754
51	MP0005499_abnormal_olfactory_system	1.51286052
52	MP0005394_taste/olfaction_phenotype	1.51286052
53	MP0003950_abnormal_plasma_membrane	1.50548656
54	MP0005058_abnormal_lysosome_morphology	1.50052762
55	MP0003890_abnormal_embryonic-extraembry	1.42958388
56	MP0002723_abnormal_immune_serum	1.42063509
57	MP0002160_abnormal_reproductive_system	1.39201411
58	MP0003123_paternal_imprinting	1.37982099
59	MP0005275_abnormal_skin_tensile	1.37725644
60	MP0009333_abnormal_splenocyte_physiolog	1.37257014
61	MP0005083_abnormal_biliary_tract	1.37029796
62	MP0002254_reproductive_system_inflammat	1.35890498
63	MP0002452_abnormal_antigen_presenting	1.34369319
64	MP0002837_dystrophic_cardiac_calcinosis	1.33454130
65	MP0001533_abnormal_skeleton_physiology	1.33372262
66	MP0004782_abnormal_surfactant_physiolog	1.33061446
67	MP0002295_abnormal_pulmonary_circulatio	1.32067410
68	MP0002796_impaired_skin_barrier	1.31126835
69	MP0010386_abnormal_urinary_bladder	1.30629477
70	MP0001542_abnormal_bone_strength	1.29756301
71	MP0003121_genomic_imprinting	1.29276482
72	MP0009764_decreased_sensitivity_to	1.24433867
73	MP0003718_maternal_effect	1.24404613
74	MP0003315_abnormal_perineum_morphology	1.23160187
75	MP0005409_darkened_coat_color	1.22535610
76	MP0004142_abnormal_muscle_tone	1.22296983
77	MP0008875_abnormal_xenobiotic_pharmacok	1.19836051
78	MP0004133_heterotaxia	1.17749061
79	MP0001819_abnormal_immune_cell	1.17384502
80	MP0002405_respiratory_system_inflammati	1.17215368
81	MP0001845_abnormal_inflammatory_respons	1.16975436
82	MP0002234_abnormal_pharynx_morphology	1.16705412
83	MP0001853_heart_inflammation	1.16016749
84	MP0000049_abnormal_middle_ear	1.15876164
85	MP0008995_early_reproductive_senescence	1.15714543
86	MP0002098_abnormal_vibrissa_morphology	1.15196064
87	MP0002420_abnormal_adaptive_immunity	1.14811661
88	MP0008469_abnormal_protein_level	1.11832035
89	MP0002210_abnormal_sex_determination	1.10883491
90	MP0001286_abnormal_eye_development	1.10554157
91	MP0001243_abnormal_dermal_layer	1.09834570
92	MP0002102_abnormal_ear_morphology	1.09550476
93	MP0001800_abnormal_humoral_immune	1.09536704
94	MP0003937_abnormal_limbs/digits/tail_de	1.08831612
95	MP0001485_abnormal_pinna_reflex	1.07867337
96	MP0002090_abnormal_vision	1.07242019
97	MP0000358_abnormal_cell_content/	1.06479706
98	MP0005253_abnormal_eye_physiology	1.06389837
99	MP0005310_abnormal_salivary_gland	1.06222555
100	MP0002233_abnormal_nose_morphology	1.06032285
101	MP0000613_abnormal_salivary_gland	1.05386042
102	MP0001905_abnormal_dopamine_level	1.05323993
103	MP0008932_abnormal_embryonic_tissue	1.05020506
104	MP0001986_abnormal_taste_sensitivity	1.04836104
105	MP0003880_abnormal_central_pattern	1.04189141
106	MP0000858_altered_metastatic_potential	1.03356386
107	MP0001188_hyperpigmentation	1.03268147
108	MP0003453_abnormal_keratinocyte_physiol	1.02003811
109	MP0002938_white_spotting	1.01988557
110	MP0001764_abnormal_homeostasis	1.00388536
111	MP0005503_abnormal_tendon_morphology	1.00369256
112	MP0001727_abnormal_embryo_implantation	1.00115554
113	MP0001984_abnormal_olfaction	0.99551473
114	MP0000631_abnormal_neuroendocrine_gland	0.99083743
115	MP0005389_reproductive_system_phenotype	0.98273946
116	MP0003567_abnormal_fetal_cardiomyocyte	0.97691002
117	MP0002933_joint_inflammation	0.97630443
118	MP0009643_abnormal_urine_homeostasis	0.97251017
119	MP0004147_increased_porphyrin_level	0.96759634
120	MP0002751_abnormal_autonomic_nervous	0.96126117
121	MP0003119_abnormal_digestive_system	0.95939406
122	MP0005551_abnormal_eye_electrophysiolog	0.95312029
123	MP0005636_abnormal_mineral_homeostasis	0.94385365
124	MP0000579_abnormal_nail_morphology	0.94006788
125	MP0005164_abnormal_response_to	0.93601641
126	MP0000538_abnormal_urinary_bladder	0.93479505
127	MP0010155_abnormal_intestine_physiology	0.92958709
128	MP0003448_altered_tumor_morphology	0.92612979
129	MP0002006_tumorigenesis	0.92422948
130	MP0003693_abnormal_embryo_hatching	0.92217269
131	MP0005332_abnormal_amino_acid	0.91658682
132	MP0000343_altered_response_to	0.91601608
133	MP0001851_eye_inflammation	0.91212247
134	MP0005395_other_phenotype	0.90011015
135	MP0001216_abnormal_epidermal_layer	0.89995173
136	MP0002638_abnormal_pupillary_reflex	0.89634477
137	MP0009840_abnormal_foam_cell	0.89628632
138	MP0005390_skeleton_phenotype	0.88452281
139	MP0001968_abnormal_touch/_nociception	0.87757513
140	MP0001929_abnormal_gametogenesis	0.86554116
141	MP0000647_abnormal_sebaceous_gland	0.86277259
142	MP0005410_abnormal_fertilization	0.85845544
143	MP0000762_abnormal_tongue_morphology	0.85679978
144	MP0000653_abnormal_sex_gland	0.84141508
145	MP0002060_abnormal_skin_morphology	0.84090800
146	MP0004272_abnormal_basement_membrane	0.83422662
147	MP0006036_abnormal_mitochondrial_physio	0.83228026
148	MP0003755_abnormal_palate_morphology	0.82803061
149	MP0002282_abnormal_trachea_morphology	0.82668684
150	MP0004947_skin_inflammation	0.82552411
151	MP0004043_abnormal_pH_regulation	0.81975197
152	MP0002095_abnormal_skin_pigmentation	0.81787331
153	MP0001697_abnormal_embryo_size	0.81598018
154	MP0001145_abnormal_male_reproductive	0.81332923
155	MP0002653_abnormal_ependyma_morphology	0.80460648
156	MP0005501_abnormal_skin_physiology	0.80329784
157	MP0005171_absent_coat_pigmentation	0.79308905
158	MP0008872_abnormal_physiological_respon	0.78259387
159	MP0004019_abnormal_vitamin_homeostasis	0.76942596
160	MP0009697_abnormal_copulation	0.76608789
161	MP0000350_abnormal_cell_proliferation	0.76500490
162	MP0000566_synostosis	0.75987588
163	MP0002111_abnormal_tail_morphology	0.75893692
164	MP0002697_abnormal_eye_size	0.75824790
165	MP0005195_abnormal_posterior_eye	0.75599132
166	MP0004215_abnormal_myocardial_fiber	0.75141759
167	MP0002876_abnormal_thyroid_physiology	0.74870262
168	MP0001666_abnormal_nutrient_absorption	0.74552916
169	MP0000470_abnormal_stomach_morphology	0.74209046
170	MP0002085_abnormal_embryonic_tissue	0.73828056
171	MP0001324_abnormal_eye_pigmentation	0.72765443
172	MP0005174_abnormal_tail_pigmentation	0.72597140
173	MP0002998_abnormal_bone_remodeling	0.72149179
174	MP0006276_abnormal_autonomic_nervous	0.70964605
175	MP0005391_vision/eye_phenotype	0.70795342
176	MP0005075_abnormal_melanosome_morpholog	0.68411147
177	MP0001919_abnormal_reproductive_system	0.65955220

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.85204255
2	Parakeratosis (HP:0001036)	4.33824819
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.33162873
4	Reticulocytopenia (HP:0001896)	4.26912148
5	Mitochondrial inheritance (HP:0001427)	4.25253986
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.23653843
7	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.14189067
8	Renal Fanconi syndrome (HP:0001994)	4.07921288
9	Abnormal hemoglobin (HP:0011902)	4.02188984
10	Acute encephalopathy (HP:0006846)	3.98367335
11	Progressive macrocephaly (HP:0004481)	3.88332040
12	Increased hepatocellular lipid droplets (HP:0006565)	3.82945092
13	Abnormal number of erythroid precursors (HP:0012131)	3.69128257
14	Macrocytic anemia (HP:0001972)	3.57848454
15	Lipid accumulation in hepatocytes (HP:0006561)	3.47247314
16	Exertional dyspnea (HP:0002875)	3.47182093
17	Increased CSF lactate (HP:0002490)	3.42471962
18	Congenital ichthyosiform erythroderma (HP:0007431)	3.41911979
19	Hepatocellular necrosis (HP:0001404)	3.26533892
20	Hepatic necrosis (HP:0002605)	3.15238367
21	Abnormality of renal resorption (HP:0011038)	3.11695431
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.05990496
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.05990496
24	3-Methylglutaconic aciduria (HP:0003535)	3.00722757
25	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.00342199
26	Pallor (HP:0000980)	2.99833238
27	Abnormality of macrophages (HP:0004311)	2.97143104
28	Vacuolated lymphocytes (HP:0001922)	2.92156014
29	Recurrent abscess formation (HP:0002722)	2.86149430
30	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.82746397
31	Recurrent bacterial skin infections (HP:0005406)	2.77433642
32	Cerebral edema (HP:0002181)	2.77318659
33	Abnormality of urine glucose concentration (HP:0011016)	2.75271107
34	Glycosuria (HP:0003076)	2.75271107
35	Methylmalonic acidemia (HP:0002912)	2.72097428
36	Oral leukoplakia (HP:0002745)	2.71817314
37	Increased intramyocellular lipid droplets (HP:0012240)	2.67624919
38	Leukodystrophy (HP:0002415)	2.66296257
39	Respiratory failure (HP:0002878)	2.63013321
40	Abnormality of methionine metabolism (HP:0010901)	2.57677751
41	Increased IgM level (HP:0003496)	2.56815317
42	Hyperphosphaturia (HP:0003109)	2.55913231
43	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.52912150
44	Hepatosplenomegaly (HP:0001433)	2.50515046
45	Eczematoid dermatitis (HP:0000976)	2.49230552
46	Stenosis of the external auditory canal (HP:0000402)	2.47853901
47	Prolonged neonatal jaundice (HP:0006579)	2.46731692
48	Aplastic anemia (HP:0001915)	2.45622226
49	Methylmalonic aciduria (HP:0012120)	2.44304434
50	Abnormality of glycolysis (HP:0004366)	2.42664041
51	Increased serum pyruvate (HP:0003542)	2.42664041
52	Septo-optic dysplasia (HP:0100842)	2.37663334
53	Lethargy (HP:0001254)	2.37381148
54	Exercise intolerance (HP:0003546)	2.34878975
55	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.32548583
56	Hypothermia (HP:0002045)	2.30111203
57	Increased muscle lipid content (HP:0009058)	2.29408336
58	Colon cancer (HP:0003003)	2.28948083
59	Molar tooth sign on MRI (HP:0002419)	2.23896716
60	Abnormality of midbrain morphology (HP:0002418)	2.23896716
61	Abnormal urine phosphate concentration (HP:0012599)	2.23330534
62	Abnormality of serum amino acid levels (HP:0003112)	2.20601135
63	Type I transferrin isoform profile (HP:0003642)	2.17061503
64	Respiratory difficulties (HP:0002880)	2.14459077
65	X-linked dominant inheritance (HP:0001423)	2.14330059
66	Optic disc pallor (HP:0000543)	2.14061478
67	Reduced antithrombin III activity (HP:0001976)	2.13648899
68	Pancreatic cysts (HP:0001737)	2.13624381
69	Pancreatic fibrosis (HP:0100732)	2.12540769
70	Megaloblastic anemia (HP:0001889)	2.11685805
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09418423
72	Abnormal protein N-linked glycosylation (HP:0012347)	2.09418423
73	Abnormal protein glycosylation (HP:0012346)	2.09418423
74	Abnormal glycosylation (HP:0012345)	2.09418423
75	Hyperglycinemia (HP:0002154)	2.08188223
76	CNS demyelination (HP:0007305)	2.07810906
77	Anhidrosis (HP:0000970)	2.06720222
78	Increased serum lactate (HP:0002151)	2.04303459
79	Elevated erythrocyte sedimentation rate (HP:0003565)	2.04128693
80	Lactic acidosis (HP:0003128)	2.03971424
81	Abnormality of placental membranes (HP:0011409)	2.03652706
82	Amniotic constriction ring (HP:0009775)	2.03652706
83	Testicular atrophy (HP:0000029)	2.00679001
84	Hypoplastic pelvis (HP:0008839)	1.98463322
85	Abnormality of magnesium homeostasis (HP:0004921)	1.98351265
86	Renal tubular dysfunction (HP:0000124)	1.97978651
87	Congenital, generalized hypertrichosis (HP:0004540)	1.95275359
88	Poor head control (HP:0002421)	1.94725697
89	Autoimmune hemolytic anemia (HP:0001890)	1.93222355
90	Proximal tubulopathy (HP:0000114)	1.92197700
91	Meckel diverticulum (HP:0002245)	1.92178837
92	Fragile nails (HP:0001808)	1.92080352
93	Axonal loss (HP:0003447)	1.89791927
94	True hermaphroditism (HP:0010459)	1.88903930
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.88522705
96	Abnormality of alanine metabolism (HP:0010916)	1.88152111
97	Hyperalaninemia (HP:0003348)	1.88152111
98	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88152111
99	Absent thumb (HP:0009777)	1.88149400
100	Congenital sensorineural hearing impairment (HP:0008527)	1.86713633
101	Absent septum pellucidum (HP:0001331)	1.85433824
102	Erythroderma (HP:0001019)	1.84933923
103	Abnormality of the labia minora (HP:0012880)	1.84908649
104	Patchy hypopigmentation of hair (HP:0011365)	1.84533013
105	Abnormality of the anterior horn cell (HP:0006802)	1.83727922
106	Degeneration of anterior horn cells (HP:0002398)	1.83727922
107	Medial flaring of the eyebrow (HP:0010747)	1.83034674
108	Generalized aminoaciduria (HP:0002909)	1.83034116
109	Rib fusion (HP:0000902)	1.82502536
110	Recurrent gram-negative bacterial infections (HP:0005420)	1.81913538
111	Abnormality of the axillary hair (HP:0100134)	1.79758594
112	Abnormality of secondary sexual hair (HP:0009888)	1.79758594
113	Abnormality of the ileum (HP:0001549)	1.79278759
114	Purpura (HP:0000979)	1.78755278
115	Hypomagnesemia (HP:0002917)	1.78190375
116	Median cleft lip (HP:0000161)	1.77873282
117	Pancytopenia (HP:0001876)	1.77626762
118	Sclerocornea (HP:0000647)	1.77105518
119	Nausea (HP:0002018)	1.77042569
120	Recurrent skin infections (HP:0001581)	1.75996982
121	Sparse eyelashes (HP:0000653)	1.75772274
122	Retrobulbar optic neuritis (HP:0100654)	1.75499249
123	Optic neuritis (HP:0100653)	1.75499249
124	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74891383
125	Abnormal lung lobation (HP:0002101)	1.74479585
126	Abnormality of the preputium (HP:0100587)	1.74182431
127	Delayed epiphyseal ossification (HP:0002663)	1.72309499
128	Thick nail (HP:0001805)	1.72176159
129	Microvesicular hepatic steatosis (HP:0001414)	1.72152876
130	Vertebral compression fractures (HP:0002953)	1.70227669
131	Cleft eyelid (HP:0000625)	1.69367447
132	Sensory axonal neuropathy (HP:0003390)	1.68040709
133	Trismus (HP:0000211)	1.67180290
134	Hypoplasia of the uterus (HP:0000013)	1.67106556
135	Blindness (HP:0000618)	1.66717903
136	Birth length less than 3rd percentile (HP:0003561)	1.65260565
137	Conical tooth (HP:0000698)	1.64853903
138	Hypoplasia of the pons (HP:0012110)	1.64436857
139	Rough bone trabeculation (HP:0100670)	1.64117232
140	Autoimmune thrombocytopenia (HP:0001973)	1.63897515
141	Systemic lupus erythematosus (HP:0002725)	1.62726607
142	Autoamputation (HP:0001218)	1.60730352
143	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.60234123
144	Orchitis (HP:0100796)	1.59917050
145	Multiple enchondromatosis (HP:0005701)	1.57567689
146	Recurrent pneumonia (HP:0006532)	1.57228591
147	Basal ganglia calcification (HP:0002135)	1.55967814
148	White forelock (HP:0002211)	1.55932542
149	Cerebral hemorrhage (HP:0001342)	1.55580901

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	4.89916062
2	VRK2	4.57048862
3	NME2	4.33161588
4	MST4	3.55210555
5	PIM2	3.00798707
6	CDC7	2.71750479
7	LIMK1	2.51273247
8	BCR	2.50003401
9	STK39	2.49830250
10	MAP3K14	2.47711431
11	TESK2	2.36581361
12	NEK1	2.33154553
13	TESK1	2.20978920
14	STK16	1.92409168
15	TRIM28	1.83851669
16	ARAF	1.81347870
17	BLK	1.79496008
18	PLK3	1.76760078
19	WNK4	1.75500272
20	WNK3	1.64783176
21	TTK	1.59701842
22	IKBKB	1.57552642
23	ABL2	1.56165216
24	BMPR1B	1.55775975
25	IRAK4	1.55684852
26	PIK3CG	1.54934910
27	OXSR1	1.54194382
28	TAF1	1.53240928
29	TLK1	1.49571858
30	TNIK	1.39763657
31	TBK1	1.35162910
32	TYK2	1.34506097
33	VRK1	1.33760994
34	PLK1	1.32897516
35	MST1R	1.30757841
36	EIF2AK3	1.28991548
37	WEE1	1.27683132
38	PDK2	1.26773852
39	IRAK3	1.25616516
40	DYRK2	1.22550931
41	MET	1.21396385
42	MAP4K2	1.20318269
43	BUB1	1.19994789
44	MKNK2	1.18404857
45	MAPKAPK5	1.17089324
46	BMPR2	1.17045407
47	EIF2AK1	1.16221894
48	NME1	1.16179407
49	MAP2K2	1.11153680
50	TSSK6	1.11028980
51	CSNK1G1	1.10016843
52	EPHB1	1.09845209
53	NEK9	1.09443130
54	AURKB	1.09259963
55	GRK1	1.08182456
56	MYLK	1.06008705
57	BRAF	1.04621588
58	RPS6KA5	1.02775652
59	CSNK1G2	0.96611915
60	MAP3K3	0.95636058
61	BCKDK	0.95488969
62	KDR	0.94210335
63	IKBKE	0.93483225
64	DYRK3	0.92338300
65	ADRBK2	0.90594797
66	EIF2AK2	0.86822754
67	TRPM7	0.86616353
68	BRSK1	0.86093094
69	GRK7	0.84554489
70	PAK4	0.84282433
71	PLK4	0.83938360
72	EPHB2	0.83651979
73	CSNK1A1L	0.83437662
74	IRAK1	0.83314511
75	LRRK2	0.82224709
76	ACVR1B	0.82126033
77	ZAK	0.78593155
78	JAK3	0.75307989
79	CHEK2	0.74959545
80	MAP2K7	0.74857479
81	MAPK15	0.71108283
82	CSNK2A2	0.70804278
83	CASK	0.70504236
84	EPHA2	0.68783689
85	TEC	0.67736178
86	PASK	0.65600838
87	NLK	0.65531643
88	ATR	0.65121593
89	PKN1	0.64002933
90	MAP3K12	0.63952296
91	ILK	0.62851355
92	IRAK2	0.60771108
93	MAP3K11	0.60153377
94	CSNK1G3	0.59975404
95	EPHA3	0.58790799
96	MUSK	0.58637117
97	TXK	0.58619967
98	NEK6	0.57585373
99	CHUK	0.56175460
100	PRKCI	0.56010401
101	CDK8	0.55932618
102	TGFBR1	0.55394242
103	STK24	0.54234789
104	NEK2	0.53384329
105	PLK2	0.53307095
106	PAK1	0.53013801
107	CCNB1	0.52816520
108	STK4	0.52803415
109	MAPKAPK2	0.51999278
110	BRSK2	0.51788418
111	STK38L	0.51258896
112	ADRBK1	0.50549217
113	INSRR	0.49704913
114	ZAP70	0.49493042
115	PRKCG	0.49267362
116	PIM1	0.48918887
117	PNCK	0.48382747
118	MOS	0.47743751
119	DAPK3	0.47740636
120	MAP3K4	0.47626393
121	PRKCD	0.47132843
122	ERBB3	0.47107142
123	RPS6KA4	0.46997856
124	OBSCN	0.45845812
125	DAPK1	0.44788258
126	YES1	0.44026223
127	CSNK2A1	0.43850586
128	CSNK1E	0.43384919
129	MINK1	0.42477882
130	SRPK1	0.42098997
131	LCK	0.40033913
132	LYN	0.39818873
133	ERBB4	0.39713276
134	MAP3K9	0.39598647
135	PRKCQ	0.38751261
136	PRKCE	0.38492341
137	MKNK1	0.38260390
138	BTK	0.38138172
139	ATM	0.37198037
140	NUAK1	0.36627632
141	WNK1	0.36053090
142	CHEK1	0.35838196
143	TIE1	0.35166364
144	FLT3	0.35043380
145	CSNK1A1	0.34981068
146	AURKA	0.34794421
147	CDK19	0.34332804

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.97109927
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.02587412
3	Proteasome_Homo sapiens_hsa03050	3.80829935
4	Protein export_Homo sapiens_hsa03060	3.63943069
5	Parkinsons disease_Homo sapiens_hsa05012	3.38288434
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.39487039
7	RNA polymerase_Homo sapiens_hsa03020	2.37643100
8	Alzheimers disease_Homo sapiens_hsa05010	2.35642444
9	Allograft rejection_Homo sapiens_hsa05330	2.25235674
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.23923045
11	Huntingtons disease_Homo sapiens_hsa05016	2.22902721
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.20179421
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.05749564
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.99051510
15	Sulfur metabolism_Homo sapiens_hsa00920	1.79562018
16	Fatty acid elongation_Homo sapiens_hsa00062	1.68394502
17	Base excision repair_Homo sapiens_hsa03410	1.64796243
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.61214817
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.57744109
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.50381880
21	RNA degradation_Homo sapiens_hsa03018	1.49167968
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43957631
23	RNA transport_Homo sapiens_hsa03013	1.43457065
24	Glutathione metabolism_Homo sapiens_hsa00480	1.36549582
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34173964
26	Folate biosynthesis_Homo sapiens_hsa00790	1.29204058
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.24262547
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.21944084
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.21897674
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.18253399
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.15353936
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15193992
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.14929276
34	Asthma_Homo sapiens_hsa05310	1.13435554
35	Propanoate metabolism_Homo sapiens_hsa00640	1.11247130
36	Histidine metabolism_Homo sapiens_hsa00340	1.09790840
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.07536428
38	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.05393861
39	Sulfur relay system_Homo sapiens_hsa04122	1.05141598
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.03403258
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.02946279
42	Legionellosis_Homo sapiens_hsa05134	1.02301729
43	Phagosome_Homo sapiens_hsa04145	1.00952440
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99145907
45	Malaria_Homo sapiens_hsa05144	0.97647229
46	Vibrio cholerae infection_Homo sapiens_hsa05110	0.96991893
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96119758
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95392509
49	Pertussis_Homo sapiens_hsa05133	0.94460233
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.92562909
51	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.92465112
52	Cell cycle_Homo sapiens_hsa04110	0.90553245
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90483819
54	Sphingolipid metabolism_Homo sapiens_hsa00600	0.90182370
55	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.90020320
56	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.89876942
57	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87969357
58	Phenylalanine metabolism_Homo sapiens_hsa00360	0.86488882
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.86335436
60	Leishmaniasis_Homo sapiens_hsa05140	0.84285195
61	Homologous recombination_Homo sapiens_hsa03440	0.82680533
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81851902
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81644048
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81585786
65	Tyrosine metabolism_Homo sapiens_hsa00350	0.76139269
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.73313223
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.73244806
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70870207
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.70741015
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69340609
71	Peroxisome_Homo sapiens_hsa04146	0.69287077
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68701998
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68479324
74	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.68372744
75	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.67893061
76	Lysosome_Homo sapiens_hsa04142	0.65271584
77	Metabolic pathways_Homo sapiens_hsa01100	0.63514215
78	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.62359169
79	Butanoate metabolism_Homo sapiens_hsa00650	0.62092057
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61857580
81	DNA replication_Homo sapiens_hsa03030	0.61799730
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.61086404
83	Basal transcription factors_Homo sapiens_hsa03022	0.59343127
84	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.57165556
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57004665
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.56790256
87	Caffeine metabolism_Homo sapiens_hsa00232	0.56495162
88	Mismatch repair_Homo sapiens_hsa03430	0.56193193
89	Carbon metabolism_Homo sapiens_hsa01200	0.55988046
90	Other glycan degradation_Homo sapiens_hsa00511	0.55821348
91	Mineral absorption_Homo sapiens_hsa04978	0.55069130
92	Spliceosome_Homo sapiens_hsa03040	0.54840450
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54649473
94	Retinol metabolism_Homo sapiens_hsa00830	0.52529455
95	Purine metabolism_Homo sapiens_hsa00230	0.52163362
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.51247078
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.50657522
98	Measles_Homo sapiens_hsa05162	0.50504102
99	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.49943086
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.49462044
101	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.48569247
102	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47968407
103	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47504052
104	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.47382496
105	Shigellosis_Homo sapiens_hsa05131	0.47168513
106	Fatty acid degradation_Homo sapiens_hsa00071	0.47164783
107	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.46028068
108	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44793492
109	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44713707
110	African trypanosomiasis_Homo sapiens_hsa05143	0.43585159
111	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43087484
112	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.42947201
113	Oocyte meiosis_Homo sapiens_hsa04114	0.42101110
114	Herpes simplex infection_Homo sapiens_hsa05168	0.41843028
115	Tuberculosis_Homo sapiens_hsa05152	0.40066591
116	Salmonella infection_Homo sapiens_hsa05132	0.40031593
117	Apoptosis_Homo sapiens_hsa04210	0.40025212
118	Phototransduction_Homo sapiens_hsa04744	0.39677927
119	mRNA surveillance pathway_Homo sapiens_hsa03015	0.38250256
120	Antigen processing and presentation_Homo sapiens_hsa04612	0.36974551
121	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36854920
122	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36062733
123	One carbon pool by folate_Homo sapiens_hsa00670	0.35501989
124	Renin-angiotensin system_Homo sapiens_hsa04614	0.35055567
125	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.35011464
126	Influenza A_Homo sapiens_hsa05164	0.33680121
127	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33237442
128	p53 signaling pathway_Homo sapiens_hsa04115	0.33190553
129	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31588736
130	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.31505619
131	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31007516
132	TNF signaling pathway_Homo sapiens_hsa04668	0.30860275
133	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.30590535
134	Fat digestion and absorption_Homo sapiens_hsa04975	0.30353114
135	Non-homologous end-joining_Homo sapiens_hsa03450	0.30221666
136	Regulation of autophagy_Homo sapiens_hsa04140	0.29506170
137	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.28257295
138	Fatty acid metabolism_Homo sapiens_hsa01212	0.25989756
139	Basal cell carcinoma_Homo sapiens_hsa05217	0.19415959
140	Nitrogen metabolism_Homo sapiens_hsa00910	0.19246111
141	Galactose metabolism_Homo sapiens_hsa00052	0.17887631
142	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.17515857
143	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.17485318
144	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.15547100
145	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.15026043
146	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.14854432

TXNDC17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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