TXNDC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.82641371
2Golgi transport vesicle coating (GO:0048200)5.82641371
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.81411010
4complement activation, classical pathway (GO:0006958)4.52240522
5protein retention in ER lumen (GO:0006621)4.45319001
6activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.38966107
7negative regulation of fibrinolysis (GO:0051918)4.24371445
8positive regulation of nuclease activity (GO:0032075)4.23768164
9endoplasmic reticulum unfolded protein response (GO:0030968)4.08159343
104-hydroxyproline metabolic process (GO:0019471)4.07427857
11COPII vesicle coating (GO:0048208)4.01323938
12complement activation (GO:0006956)3.97864952
13cellular response to unfolded protein (GO:0034620)3.89427375
14regulation of nuclease activity (GO:0032069)3.86216127
15ER-nucleus signaling pathway (GO:0006984)3.72955462
16regulation of glucose import in response to insulin stimulus (GO:2001273)3.72402398
17sulfur amino acid catabolic process (GO:0000098)3.70358415
18protein carboxylation (GO:0018214)3.68803756
19peptidyl-glutamic acid carboxylation (GO:0017187)3.68803756
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.63054629
21cellular response to topologically incorrect protein (GO:0035967)3.62673503
22protein localization to endosome (GO:0036010)3.57563318
23alpha-linolenic acid metabolic process (GO:0036109)3.56541464
24regulation of fibrinolysis (GO:0051917)3.55083859
25collagen fibril organization (GO:0030199)3.52798543
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.49805820
27L-phenylalanine metabolic process (GO:0006558)3.49805820
28skin morphogenesis (GO:0043589)3.48449491
29L-phenylalanine catabolic process (GO:0006559)3.46045032
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.46045032
31exocrine pancreas development (GO:0031017)3.44112475
32protein maturation by protein folding (GO:0022417)3.42136360
33retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.37774323
34ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.37315574
35nuclear pore complex assembly (GO:0051292)3.31149408
36regulation of protein activation cascade (GO:2000257)3.28933223
37maternal placenta development (GO:0001893)3.28761513
38regulation of cholesterol homeostasis (GO:2000188)3.28730475
39lysine metabolic process (GO:0006553)3.23932114
40lysine catabolic process (GO:0006554)3.23932114
41blood vessel maturation (GO:0001955)3.22317872
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.19838756
43* response to endoplasmic reticulum stress (GO:0034976)3.19514460
44protein heterotrimerization (GO:0070208)3.19489032
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19127309
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19127309
47signal peptide processing (GO:0006465)3.18833238
48mitotic chromosome condensation (GO:0007076)3.18644160
49regulation of plasminogen activation (GO:0010755)3.18543465
50regulation of complement activation (GO:0030449)3.16806303
51pinocytosis (GO:0006907)3.16523385
52basement membrane organization (GO:0071711)3.16353795
53wound healing, spreading of epidermal cells (GO:0035313)3.15916399
54epoxygenase P450 pathway (GO:0019373)3.13949876
55kynurenine metabolic process (GO:0070189)3.13608768
56protein activation cascade (GO:0072376)3.12960337
57UDP-N-acetylglucosamine metabolic process (GO:0006047)3.11423677
58glyoxylate metabolic process (GO:0046487)3.08339600
59complement activation, alternative pathway (GO:0006957)3.06242803
60regulation of fatty acid beta-oxidation (GO:0031998)3.05823067
61aromatic amino acid family catabolic process (GO:0009074)3.03517319
62cell-substrate junction assembly (GO:0007044)3.03476458
63high-density lipoprotein particle remodeling (GO:0034375)3.02582246
64cysteine metabolic process (GO:0006534)3.02322489
65regulation of early endosome to late endosome transport (GO:2000641)3.01665505
66homocysteine metabolic process (GO:0050667)3.01340161
67positive regulation of blood vessel endothelial cell migration (GO:0043536)3.00841610
68endodermal cell differentiation (GO:0035987)3.00402990
69mannose metabolic process (GO:0006013)2.99795045
70response to unfolded protein (GO:0006986)2.99049698
71membrane protein ectodomain proteolysis (GO:0006509)2.98230039
72lipoprotein metabolic process (GO:0042157)2.95996822
73peptidyl-proline hydroxylation (GO:0019511)2.94467201
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93974342
75morphogenesis of an endothelium (GO:0003159)2.93791309
76endothelial tube morphogenesis (GO:0061154)2.93791309
77regulation of translational fidelity (GO:0006450)2.93652429
78positive regulation of fatty acid beta-oxidation (GO:0032000)2.93347982
79proline biosynthetic process (GO:0006561)2.91147972
80hyaluronan catabolic process (GO:0030214)2.91106777
81antigen processing and presentation of endogenous antigen (GO:0019883)2.90657750
82vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.89369663
83reverse cholesterol transport (GO:0043691)2.86146098
84response to topologically incorrect protein (GO:0035966)2.85787539
85cellular modified amino acid catabolic process (GO:0042219)2.82994994
86urea metabolic process (GO:0019627)2.81794246
87urea cycle (GO:0000050)2.81794246
88plasma lipoprotein particle clearance (GO:0034381)2.81739679
89* apoptotic cell clearance (GO:0043277)2.81735560
90renal filtration (GO:0097205)2.81682058
91focal adhesion assembly (GO:0048041)2.80182090
92cell-substrate adherens junction assembly (GO:0007045)2.80182090
93peptidyl-asparagine modification (GO:0018196)2.80167184
94protein N-linked glycosylation via asparagine (GO:0018279)2.79963357
95negative regulation of sterol transport (GO:0032372)2.79852937
96negative regulation of cholesterol transport (GO:0032375)2.79852937
97valine metabolic process (GO:0006573)2.79670478
98negative regulation of fatty acid transport (GO:2000192)2.75882127
99endothelium development (GO:0003158)2.73559295
100cell adhesion mediated by integrin (GO:0033627)2.73342316
101adherens junction assembly (GO:0034333)2.73106892
102positive regulation of extracellular matrix organization (GO:1903055)2.72760998
103glycine metabolic process (GO:0006544)2.72430159
104positive regulation of endothelial cell apoptotic process (GO:2000353)2.72393134
105nucleotide-sugar biosynthetic process (GO:0009226)2.71272269
106serine family amino acid biosynthetic process (GO:0009070)2.69788888
107bile acid biosynthetic process (GO:0006699)2.69528717
108fibrinolysis (GO:0042730)2.68688705
109vesicle coating (GO:0006901)2.67944390
110indole-containing compound catabolic process (GO:0042436)2.66316983
111indolalkylamine catabolic process (GO:0046218)2.66316983
112tryptophan catabolic process (GO:0006569)2.66316983
113intestinal cholesterol absorption (GO:0030299)2.65107999
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.65021537
115fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64534107
116low-density lipoprotein particle clearance (GO:0034383)2.64430493
117type B pancreatic cell proliferation (GO:0044342)2.64221507
118negative regulation of adherens junction organization (GO:1903392)2.63496107
119negative regulation of focal adhesion assembly (GO:0051895)2.63496107
120negative regulation of cell junction assembly (GO:1901889)2.63496107
121nuclear pore organization (GO:0006999)2.62635214
122tryptophan metabolic process (GO:0006568)2.61287948
123protein hydroxylation (GO:0018126)2.60596915
124negative regulation of lipid transport (GO:0032369)2.60334049
125activation of Rac GTPase activity (GO:0032863)2.59562344
126DNA unwinding involved in DNA replication (GO:0006268)2.59350481
127glomerular filtration (GO:0003094)2.58218084
128embryonic process involved in female pregnancy (GO:0060136)2.57705544
129negative regulation of anoikis (GO:2000811)2.57598860
130hemidesmosome assembly (GO:0031581)2.57390838
131protein N-linked glycosylation (GO:0006487)2.54763031
132collagen metabolic process (GO:0032963)2.54662990
133chondrocyte proliferation (GO:0035988)2.53985910
134nitrogen cycle metabolic process (GO:0071941)2.52564541
135vascular endothelial growth factor signaling pathway (GO:0038084)2.52161008
136leukocyte tethering or rolling (GO:0050901)2.50903469
137substrate adhesion-dependent cell spreading (GO:0034446)2.47481129
138regulation of integrin activation (GO:0033623)2.46130929
139semaphorin-plexin signaling pathway (GO:0071526)2.46081411
140stress fiber assembly (GO:0043149)2.45665703
141regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.45497722
142negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45266202
143wound healing, spreading of cells (GO:0044319)2.43272355
144modulation by symbiont of host cellular process (GO:0044068)2.42046464
145endothelial cell morphogenesis (GO:0001886)2.41670656
146positive regulation of osteoblast proliferation (GO:0033690)2.39425122
147proline metabolic process (GO:0006560)2.38602945
148adhesion of symbiont to host (GO:0044406)2.35390510
149ER overload response (GO:0006983)2.34633543
150regulation of mammary gland epithelial cell proliferation (GO:0033599)2.33789129
151chondrocyte development (GO:0002063)2.33740378
152intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.31781167
153positive regulation of receptor recycling (GO:0001921)2.31169455
154positive regulation of DNA-dependent DNA replication (GO:2000105)2.29829325
155viral entry into host cell (GO:0046718)2.28487786
156regulation of glomerular filtration (GO:0003093)2.27275327
157negative regulation of cell size (GO:0045792)2.26982445
158platelet degranulation (GO:0002576)2.25992479
159gonadal mesoderm development (GO:0007506)11.1272322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.12850550
2E2F7_22180533_ChIP-Seq_HELA_Human4.64268446
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.18879810
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.97646922
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71914860
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.52161752
7CLOCK_20551151_ChIP-Seq_293T_Human3.42365401
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.31019071
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.25106027
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91791441
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.86506611
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58434628
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.49117669
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37352343
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.23324191
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.10175148
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.08974866
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02023799
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00272172
20MYC_22102868_ChIP-Seq_BL_Human1.96182060
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.91052796
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90561682
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.89321967
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88786409
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86936411
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.82512188
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.78949894
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75757784
29* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73745853
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71149370
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69285667
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63618500
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62570163
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62243170
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.59354075
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59027124
37ATF3_27146783_Chip-Seq_COLON_Human1.56537780
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55546345
39LXR_22292898_ChIP-Seq_THP-1_Human1.55422289
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52371889
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51106695
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51072252
43* RACK7_27058665_Chip-Seq_MCF-7_Human1.46538803
44ZNF263_19887448_ChIP-Seq_K562_Human1.43074275
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.41618022
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39691511
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39353711
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39170554
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.38427720
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37950413
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35142962
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34503416
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.32726663
54TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31557772
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.30120493
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29837123
57VDR_21846776_ChIP-Seq_THP-1_Human1.29112636
58* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27097192
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26360499
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24382804
61* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23452245
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23143832
63* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21776424
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.19530416
65* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18647915
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18558348
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16789683
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16578739
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16374007
70* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16162097
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15603041
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15300365
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15043138
74AR_21909140_ChIP-Seq_LNCAP_Human1.13495525
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13008687
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12592993
77GATA6_25053715_ChIP-Seq_YYC3_Human1.12161066
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11600619
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11420159
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10230900
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10097895
82GATA4_25053715_ChIP-Seq_YYC3_Human1.09402701
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09084247
84* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08866794
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08564942
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08540798
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08030976
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08012365
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07812197
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07542320
91TP53_22127205_ChIP-Seq_IMR90_Human1.07131964
92TCF7_22412390_ChIP-Seq_EML_Mouse1.05829826
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05578662
94VDR_24763502_ChIP-Seq_THP-1_Human1.04759195
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04077065
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02821719
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02783947
98KDM2B_26808549_Chip-Seq_DND41_Human1.01880752
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01598678
100* KDM2B_26808549_Chip-Seq_K562_Human1.00257403
101MAF_26560356_Chip-Seq_TH1_Human0.99234986
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98990250
103CHD1_26751641_Chip-Seq_LNCaP_Human0.98941607
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98638688
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98370949
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96905289
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96750893
108* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96416769
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96220914
110* TBX20_22080862_ChIP-Seq_HEART_Mouse0.96138801
111* TBX20_22328084_ChIP-Seq_HEART_Mouse0.96138801
112* NCOR1_26117541_ChIP-Seq_K562_Human0.95287411
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95261328
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95261328
115SOX2_20726797_ChIP-Seq_SW620_Human0.95006047
116* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94749224
117SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94194555
118WT1_19549856_ChIP-ChIP_CCG9911_Human0.92997228
119BRD4_25478319_ChIP-Seq_HGPS_Human0.92853103
120GATA1_22025678_ChIP-Seq_K562_Human0.92331072
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91523794
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.91386611
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90143246
124* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89286664
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88344691
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88138120
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87504102
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85728677
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85646124
130TFEB_21752829_ChIP-Seq_HELA_Human0.85187596
131UTX_26944678_Chip-Seq_JUKART_Human0.84421191
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84000585
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83852743
134CJUN_26792858_Chip-Seq_BT549_Human0.83770906
135* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80695882
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80474525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.25622962
2MP0003705_abnormal_hypodermis_morpholog4.34578687
3MP0002139_abnormal_hepatobiliary_system3.58792689
4MP0005360_urolithiasis3.27876900
5MP0005275_abnormal_skin_tensile3.17770202
6MP0006054_spinal_hemorrhage2.72940678
7MP0005365_abnormal_bile_salt2.65390533
8MP0010234_abnormal_vibrissa_follicle2.54433733
9MP0005503_abnormal_tendon_morphology2.46044113
10MP0005085_abnormal_gallbladder_physiolo2.44916673
11MP0003279_aneurysm2.21666187
12MP0003252_abnormal_bile_duct2.21288224
13MP0009384_cardiac_valve_regurgitation2.07417731
14MP0004272_abnormal_basement_membrane2.05992289
15MP0010352_gastrointestinal_tract_polyps2.00705310
16MP0009840_abnormal_foam_cell1.90788067
17MP0001958_emphysema1.88100978
18MP0003806_abnormal_nucleotide_metabolis1.85316949
19MP0005451_abnormal_body_composition1.84061165
20MP0003300_gastrointestinal_ulcer1.82092838
21MP0001666_abnormal_nutrient_absorption1.80209946
22MP0003566_abnormal_cell_adhesion1.80144449
23MP0005023_abnormal_wound_healing1.69183395
24MP0005083_abnormal_biliary_tract1.67811069
25MP0003195_calcinosis1.67515470
26MP0004264_abnormal_extraembryonic_tissu1.65858058
27MP0010329_abnormal_lipoprotein_level1.65771768
28MP0003941_abnormal_skin_development1.57952610
29MP0008875_abnormal_xenobiotic_pharmacok1.56579702
30MP0002060_abnormal_skin_morphology1.49616706
31MP0004233_abnormal_muscle_weight1.48691747
32MP0001348_abnormal_lacrimal_gland1.47183162
33MP0009053_abnormal_anal_canal1.44230614
34MP0005220_abnormal_exocrine_pancreas1.42491189
35MP0002396_abnormal_hematopoietic_system1.42041630
36MP0010368_abnormal_lymphatic_system1.39217807
37MP0002896_abnormal_bone_mineralization1.33589733
38MP0005409_darkened_coat_color1.31072870
39MP0002877_abnormal_melanocyte_morpholog1.27920167
40MP0003950_abnormal_plasma_membrane1.27069207
41MP0004808_abnormal_hematopoietic_stem1.24004748
42MP0000685_abnormal_immune_system1.21006347
43MP0000609_abnormal_liver_physiology1.20333889
44MP0003283_abnormal_digestive_organ1.19736755
45MP0005076_abnormal_cell_differentiation1.18779360
46MP0004858_abnormal_nervous_system1.18716710
47MP0003191_abnormal_cellular_cholesterol1.17680512
48MP0001730_embryonic_growth_arrest1.15842283
49MP0001243_abnormal_dermal_layer1.14257889
50MP0005623_abnormal_meninges_morphology1.13697738
51MP0005508_abnormal_skeleton_morphology1.13175090
52MP0005257_abnormal_intraocular_pressure1.12521277
53MP0000465_gastrointestinal_hemorrhage1.12050691
54MP0002796_impaired_skin_barrier1.11566803
55MP0004957_abnormal_blastocyst_morpholog1.10613534
56MP0001879_abnormal_lymphatic_vessel1.10500859
57MP0002295_abnormal_pulmonary_circulatio1.10035159
58MP0003111_abnormal_nucleus_morphology1.09390261
59MP0003091_abnormal_cell_migration1.09022335
60MP0005332_abnormal_amino_acid1.08678441
61MP0005171_absent_coat_pigmentation1.05416293
62MP0010030_abnormal_orbit_morphology1.03898526
63MP0005621_abnormal_cell_physiology1.01521563
64MP0008260_abnormal_autophagy1.01026185
65MP0002168_other_aberrant_phenotype0.99814857
66MP0002933_joint_inflammation0.99086427
67MP0001661_extended_life_span0.98791107
68MP0004782_abnormal_surfactant_physiolog0.98791063
69MP0010307_abnormal_tumor_latency0.98501248
70MP0000767_abnormal_smooth_muscle0.98433310
71MP0000537_abnormal_urethra_morphology0.97063858
72MP0003984_embryonic_growth_retardation0.96003589
73MP0005501_abnormal_skin_physiology0.95581892
74MP0009643_abnormal_urine_homeostasis0.95067567
75MP0000350_abnormal_cell_proliferation0.94345632
76MP0005319_abnormal_enzyme/_coenzyme0.94209399
77MP0003828_pulmonary_edema0.93544685
78MP0000013_abnormal_adipose_tissue0.93440476
79MP0000598_abnormal_liver_morphology0.92631650
80MP0003868_abnormal_feces_composition0.91414168
81MP0000003_abnormal_adipose_tissue0.91191518
82MP0003693_abnormal_embryo_hatching0.90871341
83MP0000733_abnormal_muscle_development0.90461793
84MP0002088_abnormal_embryonic_growth/wei0.89657521
85MP0005380_embryogenesis_phenotype0.86740916
86MP0001672_abnormal_embryogenesis/_devel0.86740916
87MP0003115_abnormal_respiratory_system0.85901067
88MP0002080_prenatal_lethality0.85657549
89MP0005058_abnormal_lysosome_morphology0.85091764
90MP0005464_abnormal_platelet_physiology0.83450233
91MP0009333_abnormal_splenocyte_physiolog0.82708941
92MP0000163_abnormal_cartilage_morphology0.82009153
93MP0001915_intracranial_hemorrhage0.80975082
94MP0002925_abnormal_cardiovascular_devel0.80021173
95MP0000490_abnormal_crypts_of0.79880463
96MP0005197_abnormal_uvea_morphology0.79049644
97MP0002118_abnormal_lipid_homeostasis0.77641302
98MP0002282_abnormal_trachea_morphology0.77436406
99MP0002932_abnormal_joint_morphology0.77292834
100MP0001944_abnormal_pancreas_morphology0.76690304
101MP0010155_abnormal_intestine_physiology0.76200691
102MP0001542_abnormal_bone_strength0.75356892
103MP0003077_abnormal_cell_cycle0.74823357
104MP0005390_skeleton_phenotype0.74240369
105MP0002115_abnormal_skeleton_extremities0.73751345
106MP0000678_abnormal_parathyroid_gland0.73187252
107MP0005165_increased_susceptibility_to0.71514159
108MP0001697_abnormal_embryo_size0.70859069
109MP0002128_abnormal_blood_circulation0.70759612
110MP0001533_abnormal_skeleton_physiology0.70536224
111MP0008932_abnormal_embryonic_tissue0.70361942
112MP0001849_ear_inflammation0.69814682
113MP0004197_abnormal_fetal_growth/weight/0.68880196
114MP0003795_abnormal_bone_structure0.68796212
115MP0002089_abnormal_postnatal_growth/wei0.68390291
116MP0000762_abnormal_tongue_morphology0.68276023
117MP0003448_altered_tumor_morphology0.68105331
118MP0008004_abnormal_stomach_pH0.68059358
119MP0003942_abnormal_urinary_system0.67890250
120MP0009780_abnormal_chondrocyte_physiolo0.66720098
121MP0002928_abnormal_bile_duct0.64881011
122MP0002113_abnormal_skeleton_development0.64506333
123MP0003453_abnormal_keratinocyte_physiol0.63935882
124MP0002166_altered_tumor_susceptibility0.63919362
125MP0000858_altered_metastatic_potential0.63898513
126MP0000477_abnormal_intestine_morphology0.62860461
127MP0002138_abnormal_hepatobiliary_system0.61427895
128MP0004947_skin_inflammation0.61193323
129MP0004185_abnormal_adipocyte_glucose0.61166849
130MP0003303_peritoneal_inflammation0.60782927
131MP0002135_abnormal_kidney_morphology0.60162852
132MP0005375_adipose_tissue_phenotype0.60154136
133MP0001614_abnormal_blood_vessel0.58763298
134MP0003385_abnormal_body_wall0.58214649
135MP0005084_abnormal_gallbladder_morpholo0.58195967
136MP0002136_abnormal_kidney_physiology0.57102040
137MP0000534_abnormal_ureter_morphology0.56568201
138MP0002998_abnormal_bone_remodeling0.56519424
139MP0002108_abnormal_muscle_morphology0.54378181
140MP0005408_hypopigmentation0.54318119
141MP0003045_fibrosis0.54295456
142MP0003186_abnormal_redox_activity0.53843921
143MP0000428_abnormal_craniofacial_morphol0.53799691
144MP0009931_abnormal_skin_appearance0.53561137
145MP0002086_abnormal_extraembryonic_tissu0.52323375

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.30201782
2Premature rupture of membranes (HP:0001788)5.22047579
3Deep venous thrombosis (HP:0002625)4.08616974
4Peritonitis (HP:0002586)3.70592201
5Aortic dissection (HP:0002647)3.57241000
6Cerebral aneurysm (HP:0004944)3.55177136
7Ankle contracture (HP:0006466)3.52853021
8Aortic aneurysm (HP:0004942)3.42347633
9Xanthomatosis (HP:0000991)3.34696073
10Cervical subluxation (HP:0003308)3.32317526
11Shallow orbits (HP:0000586)3.14560786
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.10586299
13Atrophic scars (HP:0001075)3.05117500
14Dilatation of the ascending aorta (HP:0005111)2.95136553
15Soft skin (HP:0000977)2.89949089
16Intrahepatic cholestasis (HP:0001406)2.85439758
17Mitral valve prolapse (HP:0001634)2.80707953
18Blue sclerae (HP:0000592)2.76883780
19Bladder diverticulum (HP:0000015)2.76422452
20Abnormality of the common coagulation pathway (HP:0010990)2.76366108
21Broad metatarsal (HP:0001783)2.71284582
22Ankyloglossia (HP:0010296)2.71209777
23Abnormality of the intrinsic pathway (HP:0010989)2.67775451
24Aneurysm (HP:0002617)2.67169280
25Biconcave vertebral bodies (HP:0004586)2.65740419
26Vertebral compression fractures (HP:0002953)2.63992410
27Abnormality of aromatic amino acid family metabolism (HP:0004338)2.62968224
28Myocardial infarction (HP:0001658)2.57180688
29Ectopia lentis (HP:0001083)2.56422683
30Genu recurvatum (HP:0002816)2.54625602
31Asymmetry of the thorax (HP:0001555)2.52108126
32Hypobetalipoproteinemia (HP:0003563)2.51092793
33Wormian bones (HP:0002645)2.51046736
34Fragile skin (HP:0001030)2.50142923
35Nonimmune hydrops fetalis (HP:0001790)2.47309423
36Neonatal short-limb short stature (HP:0008921)2.45392588
37Abnormality of oral frenula (HP:0000190)2.44427250
38Abnormality of dentin (HP:0010299)2.38365036
39Mitral stenosis (HP:0001718)2.38191864
40Complement deficiency (HP:0004431)2.36733716
41Spinal cord lesions (HP:0100561)2.35670875
42Syringomyelia (HP:0003396)2.35670875
43Back pain (HP:0003418)2.30463844
44Cardiovascular calcification (HP:0011915)2.29108200
45Trismus (HP:0000211)2.28771702
46Hypoglycemic coma (HP:0001325)2.23169083
47Increased connective tissue (HP:0009025)2.23036519
48Polycythemia (HP:0001901)2.22742551
49Coxa vara (HP:0002812)2.17955640
50Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16771219
51Hypolipoproteinemia (HP:0010981)2.16715258
52Abnormality of the acetabulum (HP:0003170)2.16712113
53Abnormal cartilage morphology (HP:0002763)2.16348122
54Thin bony cortex (HP:0002753)2.13775878
55Ulnar bowing (HP:0003031)2.12859272
56Abnormality of carpal bone ossification (HP:0006257)2.12403120
57Bowel diverticulosis (HP:0005222)2.11340051
58Hypoalphalipoproteinemia (HP:0003233)2.11140454
59Type 1 muscle fiber predominance (HP:0003803)2.10988984
60Abnormal delivery (HP:0001787)2.09809488
61Disproportionate tall stature (HP:0001519)2.08524762
62Short nail (HP:0001799)2.08517107
63Tetraparesis (HP:0002273)2.07878993
64Nuclear cataract (HP:0100018)2.06967355
65Lymphangioma (HP:0100764)2.06735038
66Spinal rigidity (HP:0003306)2.04375494
67Hyperextensible skin (HP:0000974)2.03814883
68Neonatal death (HP:0003811)2.03272515
69Camptodactyly of toe (HP:0001836)2.03112540
70Long toe (HP:0010511)1.99842169
71Distal upper limb amyotrophy (HP:0007149)1.99738972
72Upper limb amyotrophy (HP:0009129)1.99738972
73Abnormal ossification of hand bones (HP:0005921)1.99591302
74Abnormality of complement system (HP:0005339)1.99217713
75Hand muscle atrophy (HP:0009130)1.98852277
76Hemorrhage of the eye (HP:0011885)1.98696293
77Radial bowing (HP:0002986)1.96987872
78Abnormal foot bone ossification (HP:0010675)1.96022697
79Broad face (HP:0000283)1.95840679
80Hyperactive renin-angiotensin system (HP:0000841)1.95378970
81Beaking of vertebral bodies (HP:0004568)1.94502511
82Spontaneous hematomas (HP:0007420)1.93532769
83Vascular tortuosity (HP:0004948)1.93516124
84Ketosis (HP:0001946)1.93379426
85Hyperlipoproteinemia (HP:0010980)1.93337078
86Elbow flexion contracture (HP:0002987)1.93269984
87Bowing of the arm (HP:0006488)1.91521001
88Bowed forearm bones (HP:0003956)1.91521001
89Spastic diplegia (HP:0001264)1.90917511
90Skin nodule (HP:0200036)1.90746348
91Hepatocellular carcinoma (HP:0001402)1.89903867
92Hyperacusis (HP:0010780)1.89688540
93Abnormality of the Achilles tendon (HP:0005109)1.89406741
94Follicular hyperkeratosis (HP:0007502)1.88173588
95Prolonged partial thromboplastin time (HP:0003645)1.85993481
96Platyspondyly (HP:0000926)1.85834341
97Hyperammonemia (HP:0001987)1.84745724
98Osteoarthritis (HP:0002758)1.84231875
99Enlarged penis (HP:0000040)1.83914157
100Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.83797049
101Esophageal varix (HP:0002040)1.82788007
102Cupped ribs (HP:0000887)1.82246251
103Vascular calcification (HP:0004934)1.82133627
104Mildly elevated creatine phosphokinase (HP:0008180)1.79164855
105Small epiphyses (HP:0010585)1.79037235
106Striae distensae (HP:0001065)1.78713912
107Deviation of the hallux (HP:0010051)1.78602760
108Increased variability in muscle fiber diameter (HP:0003557)1.77432495
109Protuberant abdomen (HP:0001538)1.77271996
110Hallux valgus (HP:0001822)1.76656869
111Abnormality of the peritoneum (HP:0002585)1.76609630
112Joint laxity (HP:0001388)1.76594280
113Abnormal tarsal ossification (HP:0008369)1.75633378
114Subacute progressive viral hepatitis (HP:0006572)1.75263105
115Ketoacidosis (HP:0001993)1.75206265
116Osteolytic defects of the hand bones (HP:0009699)1.74824615
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.74824615
118Spondylolisthesis (HP:0003302)1.74349127
119Menorrhagia (HP:0000132)1.73581473
120Delayed closure of the anterior fontanelle (HP:0001476)1.73012974
121Abnormality of sulfur amino acid metabolism (HP:0004339)1.72257941
122Natal tooth (HP:0000695)1.71927749
123Abnormality of the lumbar spine (HP:0100712)1.71252700
124Delayed cranial suture closure (HP:0000270)1.70933747
125Wrist flexion contracture (HP:0001239)1.70537806
126Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70522224
127Fat malabsorption (HP:0002630)1.69888227
128Buphthalmos (HP:0000557)1.69762198
129Flat acetabular roof (HP:0003180)1.69342637
130Achilles tendon contracture (HP:0001771)1.68128054
131Overlapping toe (HP:0001845)1.68124450
132Arterial tortuosity (HP:0005116)1.67601290
133Abnormality of the distal phalanges of the toes (HP:0010182)1.67545772
134Interstitial pulmonary disease (HP:0006530)1.66920270
135Dysostosis multiplex (HP:0000943)1.66809192
136Joint stiffness (HP:0001387)1.66414215
137Thoracolumbar scoliosis (HP:0002944)1.65568823
138Onycholysis (HP:0001806)1.65214536
139Orthostatic hypotension (HP:0001278)1.64815800
140Long eyelashes (HP:0000527)1.63871519
141Abnormality of skeletal muscle fiber size (HP:0012084)1.63774571
142J-shaped sella turcica (HP:0002680)1.63154010
143Abnormality of the thoracic spine (HP:0100711)1.62954203
144Abnormality of the distal phalanx of the thumb (HP:0009617)1.62472608
145Urinary glycosaminoglycan excretion (HP:0003541)1.62079494
146Mucopolysacchariduria (HP:0008155)1.62079494
147Distal lower limb amyotrophy (HP:0008944)1.61211829
148Ridged nail (HP:0001807)1.61100990
149Relative macrocephaly (HP:0004482)1.60909491
150Renal duplication (HP:0000075)1.58924288
151Spinal cord compression (HP:0002176)1.57401925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.77412575
2TRIB34.60668092
3PKN23.84780193
4PRPF4B3.78705463
5TIE13.35983068
6SIK12.79739020
7IRAK32.79287066
8SMG12.56281679
9BCKDK2.52035225
10DDR22.50414939
11TTN2.35597879
12LATS12.33839569
13PDGFRA2.33492105
14EEF2K2.28343041
15ICK2.25034103
16FLT32.23871481
17PTK62.08403499
18RIPK12.00238648
19CDK121.99950731
20MAP3K101.99666443
21FRK1.93296106
22NME21.83865165
23LRRK21.67650416
24FGFR41.64526221
25SCYL21.60502306
26TAOK31.59032029
27PTK21.35642448
28LATS21.32813558
29PAK41.31252822
30PAK21.29782221
31EPHA21.23936735
32NEK91.21034022
33RPS6KA41.18019939
34TBK11.16492645
35MAP2K31.13864975
36TGFBR21.12346702
37MET1.11485112
38MAP3K31.03081490
39BMX1.02150278
40ARAF1.00268080
41TYK20.99138449
42PASK0.96265741
43EPHB20.93065889
44PIK3CG0.88488778
45MAP3K80.88393424
46EIF2AK10.87385275
47EPHA30.87374622
48TAOK20.87058488
49FER0.86953172
50MTOR0.86195909
51TESK10.84638086
52KDR0.84294522
53BRAF0.84212089
54MST1R0.83072796
55STK30.82461170
56JAK30.80303923
57STK100.80245985
58TGFBR10.79364723
59CDK80.78339827
60MAPKAPK30.76644217
61MOS0.76604962
62KSR20.75373855
63CDK60.72782036
64EPHB10.70746389
65MAP4K10.70272484
66CDK70.69423951
67RPS6KB20.68767905
68CSF1R0.68682707
69PRKD20.68451355
70PDPK10.67295198
71MELK0.66675149
72MAP2K10.66348380
73MAP3K140.65011495
74FGFR10.64935417
75TTK0.63380373
76PDGFRB0.62563941
77JAK10.62390283
78ERBB40.61887759
79PAK30.61431628
80TESK20.61136101
81RET0.59983086
82FGFR30.59583339
83FGFR20.58651465
84PRKG20.57792979
85MAPK110.57725490
86ILK0.55673252
87LMTK20.55553557
88STK40.54883274
89KIT0.54180841
90IRAK20.53412992
91DYRK1B0.53337159
92CDC42BPA0.50898423
93RAF10.50450584
94MAP2K20.49707340
95NEK20.49087426
96GRK60.48909003
97CLK10.48708821
98CAMK1D0.48420017
99IRAK40.47789666
100ZAP700.46421177
101CDK40.45599902
102STK240.45498802
103TRPM70.45305811
104BRSK10.44674962
105ABL20.43794902
106MYLK0.43432812
107AKT20.39594237
108MAPK70.39367272
109RPS6KA20.38934172
110MAP3K20.38549364
111MARK20.37973075
112MAP3K130.36831654
113CHEK10.36617514
114NTRK10.36474416
115ERBB20.36363244
116CDK90.36149902
117MAP3K70.36080590
118JAK20.33351764
119BUB10.33194595
120PBK0.33013793
121NEK10.32518588
122INSR0.31993996
123TAOK10.31908245
124CHUK0.31638555
125PRKD10.31177672
126PDK10.30570086
127MAP3K10.30342516
128STK38L0.30287461
129ROCK20.28426273
130PAK10.28404244
131EIF2AK30.28238336
132GSK3A0.28137100
133MAP3K110.27782138
134PIM20.27586586
135PRKCH0.27412445
136ITK0.27251062
137CSK0.27009095

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.87020733
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.80595313
3Nitrogen metabolism_Homo sapiens_hsa009102.66282930
4* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.58323469
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38620129
6Fatty acid degradation_Homo sapiens_hsa000712.12122330
7Complement and coagulation cascades_Homo sapiens_hsa046102.11917481
8Tryptophan metabolism_Homo sapiens_hsa003802.11855740
9Arginine biosynthesis_Homo sapiens_hsa002202.05021546
10Selenocompound metabolism_Homo sapiens_hsa004501.95412133
11Protein export_Homo sapiens_hsa030601.79313698
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76646344
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76047455
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.75309732
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74546369
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70638064
17ECM-receptor interaction_Homo sapiens_hsa045121.70528059
18N-Glycan biosynthesis_Homo sapiens_hsa005101.62159170
19Non-small cell lung cancer_Homo sapiens_hsa052231.57346763
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54090513
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53165089
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.50198717
23PPAR signaling pathway_Homo sapiens_hsa033201.50129545
24Caffeine metabolism_Homo sapiens_hsa002321.48788327
25Fat digestion and absorption_Homo sapiens_hsa049751.47856233
26Sulfur metabolism_Homo sapiens_hsa009201.45156278
27Protein digestion and absorption_Homo sapiens_hsa049741.43739303
28Fatty acid metabolism_Homo sapiens_hsa012121.42711883
29Biosynthesis of amino acids_Homo sapiens_hsa012301.31073539
30Starch and sucrose metabolism_Homo sapiens_hsa005001.30642636
31Acute myeloid leukemia_Homo sapiens_hsa052211.27280613
32Chemical carcinogenesis_Homo sapiens_hsa052041.27242533
33Folate biosynthesis_Homo sapiens_hsa007901.25077091
34One carbon pool by folate_Homo sapiens_hsa006701.24386295
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.23707346
36Focal adhesion_Homo sapiens_hsa045101.20208727
37Bladder cancer_Homo sapiens_hsa052191.17868376
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17814020
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15411391
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15080680
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14809305
42Vibrio cholerae infection_Homo sapiens_hsa051101.14046138
43Bile secretion_Homo sapiens_hsa049761.13008266
44Histidine metabolism_Homo sapiens_hsa003401.12386001
45Renal cell carcinoma_Homo sapiens_hsa052111.11274244
46Carbon metabolism_Homo sapiens_hsa012001.09849512
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08902906
48Staphylococcus aureus infection_Homo sapiens_hsa051501.08149237
49Phenylalanine metabolism_Homo sapiens_hsa003601.04850854
50beta-Alanine metabolism_Homo sapiens_hsa004101.04814838
51Propanoate metabolism_Homo sapiens_hsa006401.04579336
52Lysine degradation_Homo sapiens_hsa003101.04466940
53Endometrial cancer_Homo sapiens_hsa052131.03490432
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03465128
55Pyruvate metabolism_Homo sapiens_hsa006201.02998940
56Peroxisome_Homo sapiens_hsa041461.02321668
57Glioma_Homo sapiens_hsa052141.01367561
58Hepatitis B_Homo sapiens_hsa051611.00836331
59DNA replication_Homo sapiens_hsa030301.00698041
60Apoptosis_Homo sapiens_hsa042100.95649357
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.95189678
62Small cell lung cancer_Homo sapiens_hsa052220.95008065
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93228032
64Proteoglycans in cancer_Homo sapiens_hsa052050.93067337
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92726556
66Butanoate metabolism_Homo sapiens_hsa006500.91954447
67VEGF signaling pathway_Homo sapiens_hsa043700.90961039
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.90664811
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90229473
70Vitamin B6 metabolism_Homo sapiens_hsa007500.89234952
71Amoebiasis_Homo sapiens_hsa051460.87542099
72Cell cycle_Homo sapiens_hsa041100.87328053
73Arginine and proline metabolism_Homo sapiens_hsa003300.87094342
74Galactose metabolism_Homo sapiens_hsa000520.87070986
75HIF-1 signaling pathway_Homo sapiens_hsa040660.84992788
76Sulfur relay system_Homo sapiens_hsa041220.84872450
77Tyrosine metabolism_Homo sapiens_hsa003500.82317994
78Viral carcinogenesis_Homo sapiens_hsa052030.80540437
79Insulin resistance_Homo sapiens_hsa049310.79397243
80HTLV-I infection_Homo sapiens_hsa051660.78993675
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.78021472
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.77897625
83Hepatitis C_Homo sapiens_hsa051600.76544451
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75538800
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74628167
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74191333
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72898335
88Adherens junction_Homo sapiens_hsa045200.68980716
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.68920278
90Chronic myeloid leukemia_Homo sapiens_hsa052200.68540199
91Shigellosis_Homo sapiens_hsa051310.67850223
92Influenza A_Homo sapiens_hsa051640.67345265
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.66833908
94Melanoma_Homo sapiens_hsa052180.65967407
95Pathways in cancer_Homo sapiens_hsa052000.63936233
96Colorectal cancer_Homo sapiens_hsa052100.63693569
97Thyroid hormone synthesis_Homo sapiens_hsa049180.63660670
98B cell receptor signaling pathway_Homo sapiens_hsa046620.63396027
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62160854
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61850811
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61382965
102Retinol metabolism_Homo sapiens_hsa008300.60814790
103Pentose phosphate pathway_Homo sapiens_hsa000300.60332854
104Antigen processing and presentation_Homo sapiens_hsa046120.58958842
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58447067
106ErbB signaling pathway_Homo sapiens_hsa040120.58234226
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56445795
108Vitamin digestion and absorption_Homo sapiens_hsa049770.56351384
109Other glycan degradation_Homo sapiens_hsa005110.54855790
110Prion diseases_Homo sapiens_hsa050200.54535563
111Insulin signaling pathway_Homo sapiens_hsa049100.54240473
112Inositol phosphate metabolism_Homo sapiens_hsa005620.53606547
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.53492515
114TNF signaling pathway_Homo sapiens_hsa046680.52900755
115p53 signaling pathway_Homo sapiens_hsa041150.52711910
116ABC transporters_Homo sapiens_hsa020100.52448608
117Measles_Homo sapiens_hsa051620.51426417
118Glutathione metabolism_Homo sapiens_hsa004800.50611670
119Renin-angiotensin system_Homo sapiens_hsa046140.49531135
120mTOR signaling pathway_Homo sapiens_hsa041500.49468237
121Lysosome_Homo sapiens_hsa041420.48728037
122Sphingolipid metabolism_Homo sapiens_hsa006000.48125210
123Notch signaling pathway_Homo sapiens_hsa043300.45694889
124Malaria_Homo sapiens_hsa051440.45017097
125Prolactin signaling pathway_Homo sapiens_hsa049170.44700632
126MicroRNAs in cancer_Homo sapiens_hsa052060.44196340
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43847751
128Basal cell carcinoma_Homo sapiens_hsa052170.42704136
129TGF-beta signaling pathway_Homo sapiens_hsa043500.42325279
130Endocytosis_Homo sapiens_hsa041440.42259664
131Hippo signaling pathway_Homo sapiens_hsa043900.42004847
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41864240
133Glycerolipid metabolism_Homo sapiens_hsa005610.41847765
134Toxoplasmosis_Homo sapiens_hsa051450.41327760
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.40448809
136Viral myocarditis_Homo sapiens_hsa054160.40391474
137Prostate cancer_Homo sapiens_hsa052150.40220111
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39578443
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.39534131
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39257238
141GnRH signaling pathway_Homo sapiens_hsa049120.38973287
142Pancreatic cancer_Homo sapiens_hsa052120.38694632
143Estrogen signaling pathway_Homo sapiens_hsa049150.37907218
144Choline metabolism in cancer_Homo sapiens_hsa052310.36970809
145FoxO signaling pathway_Homo sapiens_hsa040680.36630374
146Dilated cardiomyopathy_Homo sapiens_hsa054140.36539428
147Fructose and mannose metabolism_Homo sapiens_hsa000510.36479224
148mRNA surveillance pathway_Homo sapiens_hsa030150.36474438
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.35803822
150Thyroid cancer_Homo sapiens_hsa052160.34647321

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